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au:NAVES, LUCIANA A.

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Synthesis, Antimicrobial Activity and Structure-Activity Relationship of Some 5-Arylidene-thiazolidine-2,4-dione Derivatives
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Paiva, Raíssa K. C. de

; Silva, Jamerson F. da

; Moreira, Hudieyllen A.

; Pinto, Osvaldo G.

; Camargo, Lilian T. F. M.

; Naves, Plínio L. F.

; Camargo, Ademir J.

; Ribeiro, Luciano

; Ramos, Luciana M.

Journal of the Brazilian Chemical Society

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jan 2019, Volume 30 N. 1 Pages 164 - 172

Abstract: En | Text: En | PDF: En

Derivatives of the thiazolidine-2,4-dione core represent a heterocyclic class with several correlated properties. In this context, the synthesis of structural analogues of these bioactive substances becomes attractive in the field of medicinal chemistry. These analogues act as antimicrobial agents against Gram-positives pathogens. The present work aimed to synthesize 10 different derivatives of 5-arylidene-thiazolidine-2,4-dione, employing urea as the catalyst in a solvent-free reaction medium, with yields that ranged from 45 to 99%. The compounds obtained were submitted to an antimicrobial assay against S. aureus ATCC 29213. Two compounds presented minimum inhibitory concentration of 62.5 and 32.5 µg mL-1 and minimum bactericidal concentration < 500 µg mL-1, demonstrating their antibacterial potential. Principal component analysis was carried out to discriminate the compounds in active and inactive classes. Four geometric and electronic molecular descriptors were required to completely discriminate the compounds. The selected descriptors can guide us in designing new 5-arylidene-thiazolidine-2,4-dione derivatives with enhanced activity.

https://doi.org/10.21577/0103-5053.20180167 1397 downloads

Desenvolvimento de Urochloa brizantha adubada com fonolito e inoculada com bactérias diazotróficas solubilizadoras de potássio
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Miranda, Cássia C. B.

; Florentino, Ligiane A.

; Rezende, Adauton V. de

; Nogueira, Denismar A.

; Leite, Rafael F.

; Naves, Luciana P.

Revista de Ciências Agrárias

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sep 2018, Volume 41 N. 3 Pages 41 - 50

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivou-se analisar a viabilidade de uso do pó da rocha fonolito em Urochloa brizantha cv. Marandu e se a inoculação com bactérias diazotróficas solubilizadoras de potássio (K) contribui para o maior desenvolvimento e características bromatológicas desta forrageira. O experimento foi conduzido em vasos contendo 15 dm³ de solo, durante três períodos de cortes. Foi utilizado o delineamento em blocos casualizados em esquema fatorial e um tratamento adicional (4x3+1), sendo quatro doses do fonolito (100%, 75%, 50% e 25%) e três variáveis inoculantes (UNIFENAS 100-13, UNIFENAS 100-94 e o controle sem inoculação), além do tratamento adicional com cloreto de potássio (KCl), com quatro repetições por tratamento. Na época de cada corte foram avaliados os parâmetros morfológicos e bromatológicos da forrageira. As diferentes doses de fonolito associadas à inoculação com as estirpes bacterianas não conduziram a diferenças significativas nos parâmetros morfológicos, como largura e comprimento de folha, densidade de perfilhos e matéria seca. No entanto, o fonolito promoveu uma melhoria nas características bromatológicas nos parâmetros de fibra em detergente ácido, hemicelulose, digestibilidade da matéria seca, nutrientes digestíveis totais, energia digestível e metabolizável, contribuindo, portanto, para a melhoria no valor nutricional, indicando o potencial de utilização desta rocha silicatada como fonte alternativa ao cloreto de potássio (KCl).

The objective of this study was to analyze the feasibility of using phonolite rock powder in Urochloa brizantha cv. Marandu and whether the inoculation with potassium solubilizing diazotrophic bacteria (K) contributes to a greater development and bromatological characteristics of this forage. The experiment was conducted in pots containing 15 dm³ of soil, during three cutting periods. A randomized block design in a factorial scheme and an additional treatment (4x3 + 1) were used, with four doses of phonolite (100%, 75%, 50% and 25%) and three inoculant variables (UNIFENAS 100-13, UNIFENAS 100-94 and a control without inoculation), further, was added the additional treatment with potassium chloride (KCl), with four replicates per treatment. At the time of each cut, the morphological and bromatological parameters of the forage were evaluated. The different doses of phonolite associated with inoculation with the bacterial strains showed no significant differences in morphological parameters, such as leaf width and length, tillers density and dry matter. However, phonolite promoted an improvement in the bromatological characteristics in the parameters of acid detergent fiber, hemicellulose, dry matter digestibility, total digestible nutrients, digestible and metabolizable energy, thus contributing to the improvement in nutritional value, indicating the potential of this rock as an alternative source to potassium chloride (KCl).

https://doi.org/10.19084/RCA17011 966 downloads

Controversial issues in the management of hyperprolactinemia and prolactinomas – An overview by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism
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Vilar, Lucio

; Abucham, Julio

; Albuquerque, José Luciano

; Araujo, Luiz Antônio

; Azevedo, Monalisa F.

; Boguszewski, Cesar Luiz

; Casulari, Luiz Augusto

; Cunha Neto, Malebranche B. C.

; Czepielewski, Mauro A.

; Duarte, Felipe H. G.

; Faria, Manuel dos S.

; Gadelha, Monica R.

; Garmes, Heraldo M.

; Glezer, Andrea

; Gurgel, Maria Helane

; Jallad, Raquel S.

; Martins, Manoel

; Miranda, Paulo A. C.

; Montenegro, Renan M.

; Musolino, Nina R. C.

; Naves, Luciana A.

; Ribeiro-Oliveira Júnior, Antônio

; Silva, Cíntia M. S.

; Viecceli, Camila

; Bronstein, Marcello D.

Archives of Endocrinology and Metabolism

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mar 2018, Volume 62 N. 2 Pages 236 - 263

Abstract: En | Text: En | PDF: En

ABSTRACT Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction, drug-induced hyperprolactinemia or systemic diseases present with PRL levels < 100 ng/mL. However, exceptions to these rules are not rare. On the other hand, among patients with macroprolactinomas (MACs), artificially low PRL levels may result from the so-called “hook effect”. Patients harboring cystic MACs may also present with a mild PRL elevation. The screening for macroprolactin is mostly indicated for asymptomatic patients and those with apparent idiopathic hyperprolactinemia. Dopamine agonists (DAs) are the treatment of choice for prolactinomas, particularly cabergoline, which is more effective and better tolerated than bromocriptine. After 2 years of successful treatment, DA withdrawal should be considered in all cases of microprolactinomas and in selected cases of MACs. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) is to provide a review of the diagnosis and treatment of hyperprolactinemia and prolactinomas, emphasizing controversial issues regarding these topics. This review is based on data published in the literature and the authors' experience.

https://doi.org/10.20945/2359-3997000000032 36158 downloads

A review of Cushing's disease treatment by the Department of Neuroendocrinology of the Brazilian Society of Endocrinology and Metabolism
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Machado, Márcio Carlos

; Fragoso, Maria Candida Barisson Vilares

; Moreira, Ayrton Custódio

; Boguszewski, César Luiz

; Vieira Neto, Leonardo

; Naves, Luciana A.

; Vilar, Lucio

; Araújo, Luiz Antônio de

; Musolino, Nina Rosa Castro

; Miranda, Paulo Augusto C.

; Czepielewski, Mauro A.

; Gadelha, Monica R.

; Bronstein, Marcello Delano

; Ribeiro-Oliveira Jr., Antônio

Archives of Endocrinology and Metabolism

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feb 2018, Volume 62 N. 1 Pages 87 - 105

Abstract: En | Text: En | PDF: En

ABSTRACT The treatment objectives for a patient with Cushing's disease (CD) are remission of hypercortisolism, adequate management of co-morbidities, restoration of the hypothalamic-pituitary-adrenal axis, preservation of fertility and pituitary function, and improvement of visual defects in cases of macroadenomas with suprasellar extension. Transsphenoidal pituitary surgery is the main treatment option for the majority of cases, even in macroadenomas with low probability of remission. In cases of surgical failure, another subsequent pituitary surgery might be indicated in cases with persistent tumor imaging at post surgical magnetic resonance imaging (MRI) and/or pathology analysis of adrenocorticotropic hormone-positive (ACTH+) positive pituitary adenoma in the first procedure. Medical treatment, radiotherapy and adrenalectomy are the other options when transsphenoidal pituitary surgery fails. There are several options of medical treatment, although cabergoline and ketoconazole are the most commonly used alone or in combination. Novel treatments are also addressed in this review. Different therapeutic approaches are frequently needed on an individual basis, both before and, particularly, after surgery, and they should be individualized. The objective of the present review is to provide the necessary information to achieve a more effective treatment for CD. It is recommended that patients with CD be followed at tertiary care centers with experience in treating this condition.

https://doi.org/10.20945/2359-3997000000014 5266 downloads

A review on the diagnosis and treatment of patients with clinically nonfunctioning pituitary adenoma by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism
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Vieira Neto, Leonardo

; Boguszewski, Cesar L.

; Araújo, Luiz Antônio de

; Bronstein, Marcello D.

; Miranda, Paulo Augusto C.

; Musolino, Nina R. de C.

; Naves, Luciana A.

; Vilar, Lucio

; Ribeiro-Oliveira Júnior, Antônio

; Gadelha, Mônica R.

Archives of Endocrinology and Metabolism

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aug 2016, Volume 60 N. 4 Pages 374 - 390

Abstract: En | Text: En | PDF: En

ABSTRACT Clinically nonfunctioning pituitary adenomas (NFPA) are the most common pituitary tumors after prolactinomas. The absence of clinical symptoms of hormonal hypersecretion can contribute to the late diagnosis of the disease. Thus, the majority of patients seek medical attention for signs and symptoms resulting from mass effect, such as neuro-ophthalmologic symptoms and hypopituitarism. Other presentations include pituitary apoplexy or an incidental finding on imaging studies. Mass effect and hypopituitarism impose high morbidity and mortality. However, early diagnosis and effective treatment minimizes morbidity and mortality. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism is to provide a review of the diagnosis and treatment of patients with NFPA, emphasizing that the treatment should be performed in reference centers. This review is based on data published in the literature and the authors’ experience. Arch Endocrinol Metab. 2016;60(4):374-90

https://doi.org/10.1590/2359-3997000000179 7830 downloads

Recommendations of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism for the diagnosis of Cushing’s disease in Brazil
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Machado, Márcio Carlos

; Fragoso, Maria Candida Barisson Vilares

; Moreira, Ayrton Custódio

; Boguszewski, César Luiz

; Vieira Neto, Leonardo

; Naves, Luciana A.

; Vilar, Lucio

; Araújo, Luiz Antônio de

; Czepielewski, Mauro A.

; Gadelha, Monica R.

; Musolino, Nina Rosa Castro

; Miranda, Paulo Augusto C.

; Bronstein, Marcello Delano

; Ribeiro-Oliveira Jr., Antônio

Archives of Endocrinology and Metabolism

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jun 2016, Volume 60 N. 3 Pages 267 - 286

Abstract: En | Text: En | PDF: En

ABSTRACT Although it is a rare condition, the accurate diagnosis and treatment of Cushing’s disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing’s syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. Routine screening is not recommended for other groups of patients, such as those with obesity or diabetes mellitus. Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. Bilateral and simultaneous petrosal sinus sampling is the gold standard method and is performed when the triad of initial tests is inconclusive, doubtful or conflicting. The aim of this article is to provide information on the early detection and establishment of a proper diagnosis of Cushing’s disease, recommending follow-up of these patients at experienced referral centers. Arch Endocrinol Metab. 2016;60(3):267-86

https://doi.org/10.1590/2359-3997000000174 6344 downloads

Activity of fungal phytases stored in two ways in response to the period of storage at room temperature
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Naves, Luciana de Paula

; Corrêa, Angelita Duarte

; Bertechini, Antônio Gilberto

; Gomide, Elisangela Minati

; Abreu, Celeste Maria Patto de

Ciência Rural

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2012, Volume 42 N. 1 Pages 178 - 183

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Dois experimentos distintos foram realizados simultaneamente com fitases de Aspergillus oryzae e A. niger para a determinação da atividade enzimática em resposta ao período de armazenamento (por até 180 dias em temperatura ambiente - TA). No primeiro experimento, as enzimas foram armazenadas como adquiridas (forma pura) e a atividade foi determinada periodicamente durante 180 dias de armazenamento em TA. No segundo experimento, as fitases foram incorporadas a um suplemento contendo vitaminas, minerais e aminoácidos. Então este suplemento foi armazenado em TA por até 180 dias, de modo que, a cada 30 dias de armazenamento, uma alíquota de cada repetição foi coletada para a determinação da atividade enzimática. Conclui-se que a atividade da fitase é afetada pela duração do armazenamento. Para assegurar 80% da atividade inicial, as fitases de A. oryzae e A. niger podem ser armazenadas nas formas pura por até 53 e 135 dias em TA, respectivamente. Entretanto, se as fitases de A. oryzae e A. niger são incorporadas a um suplemento contendo vitaminas, minerais e aminoácidos, o período de armazenamento em TA não deve exceder 67 e 77 dias, respectivamente.

Two distinct experiments were conducted simultaneously with phytases of Aspergillus oryzae and A. niger for determining enzyme activity in response to storage period (up to 180 days at room temperature - RT). In the first experiment, enzymes were stored as they were acquired (pure form) and the activity was measured periodically during 180 days of storage at RT. In the second experiment, the phytases were incorporated to a supplement containing vitamins, minerals, and amino acids; and then this supplement was stored at RT up to 180 days, so that every 30 days of storage was collected one aliquot from each replicate for determining enzymatic activity. In conclusion, the phytase activity is affected by storage duration. To ensure 80% of the initial activity, the phytases of A. oryzae and A. niger can be stored in the pure forms for up to 53 and 135 days at RT, respectively. However, if the phytases of A. oryzae and A. niger are incorporated to a supplement containing vitamins, minerals, and amino acids then the storage period at RT should not exceed 67 and 77 days, respectively.

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Recomendações do Departamento de Neuroendocrinologia da Sociedade Brasileira de Endocrinologia e Metabologia para o Diagnóstico e Tratamento da Acromegalia no Brasil
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Vieira Neto, Leonardo

; Abucham, Julio

; Araujo, Luiz Antônio de

; Boguszewski, Cesar L.

; Bronstein, Marcello D.

; Czepielewski, Mauro

; Jallad, Raquel S.

; Musolino, Nina R. de C.

; Naves, Luciana A.

; Ribeiro-Oliveira Júnior, Antônio

; Vilar, Lucio

; Faria, Manuel dos S.

; Gadelha, Mônica R.

Arquivos Brasileiros de Endocrinologia & Metabologia

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dec 2011, Volume 55 N. 9 Pages 725 - 726

Abstract: Pt | Text: Pt | PDF: Pt

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Recomendações do Departamento de Neuroendocrinologia da Sociedade Brasileira de Endocrinologia e Metabologia para o diagnóstico e tratamento da acromegalia no Brasil
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Vieira Neto, Leonardo

; Abucham, Julio

; Araujo, Luiz Antônio de

; Boguszewski, Cesar L.

; Bronstein, Marcello D.

; Czepielewski, Mauro

; Jallad, Raquel S.

; Musolino, Nina R. de C.

; Naves, Luciana A.

; Ribeiro-Oliveira Júnior, Antônio

; Vilar, Lucio

; Faria, Manuel dos S.

; Gadelha, Mônica R.

Arquivos Brasileiros de Endocrinologia & Metabologia

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mar 2011, Volume 55 N. 2 Pages 91 - 105

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A acromegalia é uma doença associada à elevada morbidade e à redução da expectativa de vida. Em virtude do seu caráter insidioso e do seu não reconhecimento, o diagnóstico é frequentemente realizado com atraso, o que, associado às complicações relacionadas ao excesso do GH/IGF-I, determina elevada morbimortalidade. No entanto, um diagnóstico precoce e um tratamento efetivo minimizam a morbidade e normalizam a taxa de mortalidade. Nesta publicação, o objetivo do Departamento de Neuroendocrinologia da Sociedade Brasileira de Endocrinologia e Metabologia é divulgar quando suspeitar clinicamente da acromegalia e como diagnosticá-la. Além disso, discute-se a maneira mais eficaz e segura de realizar o tratamento da acromegalia, enfatizando que este deve ser realizado em centros de referência. Assim, com base em dados publicados em periódicos de nível científico reconhecido e na experiência dos autores, são apresentadas as recomendações para o diagnóstico e tratamento da doença.

Acromegaly is a disease associated with increased morbidity and reduced life expectancy. Because of its insidious character and its non-recognition, the diagnosis is often made with delay, which, along with the complications related to GH/IGF-I excess, determines high morbidity and mortality. However, an early diagnosis and an effective treatment reduce the morbidity and normalize the mortality rate. In this publication, the goal of Neuroendocrinology Department from Brazilian Society of Endocrinology and Metabolism is to disclose which clinical set should arouse the suspicious of acromegaly and how to diagnose it. Furthermore, we discuss the most effective and safe approach to perform the treatment of acromegaly, emphasizing that it must be carried out in reference centers. Therefore, based on data published in journals with recognized scientific level and authors' experience, recommendations are presented for diagnosis and treatment of the disease.

17700 downloads

10.

The brazilian version of the Quality of Life Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA): Four-stage translation and validation
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Ribeiro-Oliveira Jr, Antônio

; Mol, Suélem Simão

; Twiss, James

; Alencar, Guilherme Asmar

; Miranda, Paulo Augusto Carvalho

; Naves, Luciana A.

; Azevedo, Monalisa F.

; Basílio, Flávia M. A.

; Boguszewski, César Luiz

; Nogueira, Kátia C.

; Vilar, Lúcio

; Koltowska-Haggstrom, Maria

; McKenna, Steve P.

Arquivos Brasileiros de Endocrinologia & Metabologia

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dec 2010, Volume 54 N. 9 Pages 833 - 841

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Este estudo relata o processo de adaptação da versão brasileira do questionário QoL-AGHDA (Quality of Life - Assessment of Growth Hormone Deficiency in Adults) para pacientes com deficiência do hormônio de crescimento (DGH). MATERIAIS E MÉTODOS: A tradução adotou a metodologia de duplo painel. O questionário foi testado por intermédio de entrevistas direcionadas com 16 pacientes com DGH. No estágio final, dados de 120 pacientes com DGH (81 com teste/reteste) foram analisados para consistência interna, confiabilidade teste/reteste, validade convergente e validade entre grupos conhecidos. RESULTADOS: Os grupos de tradução foram bem-sucedidos e a versão final foi adaptada seguindo sugestões obtidas das entrevistas com os 16 pacientes. O coeficiente alfa de Cronbach foi 0,90, confiabilidade teste/reteste 0,88, escores QoL-AGHDA se correlacionaram com o NHP (p < 0,01) e também com a saúde geral relatada pelos pacientes (p < 0,01). CONCLUSÕES: A adaptação do QoL-AGHDA para a população brasileira foi bem-sucedida, e a nova versão demonstrou ser válida e confiável.

OBJECTIVE: This study reports on the Brazilian Portuguese adaptation of the QoL-AGHDA (Quality of Life Assessment of Growth Hormone Deficiency in Adults) for use in adult growth hormone deficient (GHD) patients. MATERIALS AND METHODS: The translation process adopted the dual panel methodology. The questionnaire was tested through field-test interviews (16 GHD patients). In the final stage, data from 120 GHD patients (81 included in a test-retest analysis) were analyzed for internal consistency, test-retest reliability, convergent validity and validity among known groups. RESULTS: The translation panels were successful and the draft version was amended to improve the wording as a result of the field-test interviews. Cronbach's alpha was 0.90 and test-retest reliability 0.88. QoL-AGHDA scores had the expected pattern of association with NHP scale scores and QoL-AGHDA was able to differentiate significantly between patients based on patient-reported general health (p < 0.01) and QoL (p < 0.01). CONCLUSIONS: The adaptation of the QoL-AGHDA for a Brazilian population was successful and the adapted questionnaire was shown to be reliable and valid.

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11.

Crescimento e desenvolvimento de cultivares de bananeira irrigadas
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Braga Filho, Juracy Rocha

; Nascimento, Jorge Luiz do

; Naves, Ronaldo Veloso

; Silva, Luciana Borges e

; Pereira, Arcângela Custódia da Conceição Pedreira

; Gonçalves, Helenice Moura

; Rodrigues, Cristiane

Revista Brasileira de Fruticultura

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dec 2008, Volume 30 N. 4 Pages 981 - 988

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este estudo teve como objetivo avaliar o comportamento vegetativo de cultivares de bananeira sob lâminas de irrigação. As lâminas de irrigação corresponderam à testemunha, 40; 80 e 120% da evapotranspiração potencial da cultura estimada a partir da evaporação do tanque classe A. O experimento foi conduzido no período de 24 de janeiro de 2004 a 23 de janeiro de 2006, com as cultivares: falsa FHIA 18, Grande Naine, Prata e Thap Maeo. As quatro cultivares apresentaram respostas significativas às lâminas de irrigação, no entanto falsa FHIA 18 teve o maior número de variáveis influenciadas. O uso da irrigação influenciou de forma diferenciada no comportamento das cultivares. O efeito de lâminas dentro de cultivares, aos quatro meses após o plantio, ocorreu apenas na cultivar Prata para a altura de plantas, aos oito meses do plantio em todas as cultivares e variáveis. Na ocasião da colheita, houve efeito das lâminas de irrigação dentro das quatro cultivares. No segundo ciclo, não se verificou resposta à irrigação aos quatro e oito meses da escolha do primeiro seguidor; ocorreu o efeito de cultivares e resposta à irrigação no número de folhas viáveis aos quatro meses dentro de Grande Naine, e na altura de plantas e no diâmetro aos oito meses. O crescimento e o desenvolvimento vegetativo das cultivares falsa FHIA 18, Grande Naine, Prata e Thap Maeo, nas condições do Cerrado, são influenciados positivamente com o uso da irrigação. O ciclo total das quatro cultivares diminui com o uso da irrigação.

This study had the objective of evaluating the vegetative cultivars behavior of banana orchard under levels of irrigation. The irrigation levels indicated the control 40, 80 and 120% of the evaporation-transpiration potential of the culture based on evaporation in a classe- A tank. The experiment was lead in the period of January 24, 2004 through January 23, 2006, with the cultivars of: false FHIA 18, Grand Naine, Prata and Thap Maeo. The four cultivars presented significant answers to the irrigation levels, however false FHIA 18 had the biggest number of variables influenced by the irrigation levels. The use of the irrigation levels influenced the behavior of the cultivars in a differentiated manner. The effect of levels inside the cultivars, four months after the plantation, affected only the height of plants in the Prata cultivars. By eight months, every cultivars and variables were affected. At the time of harvest, the levels of irrigation had affected all the four cultivars. During the second cycle, a feedback to the irrigation levels was not observed in the four and eight months of the first follower; the effect occurred to the cultivars and the feedback to the irrigation in the number of viable leaves by four months of the cultivars Grand Naine, and in the height of plants and in the diameter by eight months. The growth and the vegetative development of the false FHIA 18, Grand Naine, Prata and Thap Maeo cultivars in the conditions of the open pasture are positively influenced with the use of the irrigation. The total cycle of the four cultivars decreases with the use of the irrigation.

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12.

A novel mutation of thyroid hormone receptor beta (I431V) impairs corepressor release, and induces thyroid hormone resistance syndrome
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Ferreira Azevedo, Monalisa

; Barra, Gustavo Barcelos

; Medeiros, Ligiane Dantas de

; Simeoni, Luiz Alberto

; Naves, Luciana Ansaneli

; Neves, Francisco de A. Rocha

Arquivos Brasileiros de Endocrinologia & Metabologia

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nov 2008, Volume 52 N. 8 Pages 1304 - 1312

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A resistência ao hormônio tireoideano (RHT) é uma doença rara, causada por variável hiporresponsividade dos tecidos aos hormônios tireoideanos, usualmente causada por mutações no receptor beta do hormônio tireoideano (TRβ). Descrevemos uma grande família brasileira portadora de uma nova mutação afetando o gene do TRβ, induzindo RHT. Uma paciente de 14 anos de idade apresentou concentrações plasmáticas elevadas de T4 e T3 livres, associadas a TSH não-suprimido e bócio questionável. O diagnóstico de RHT foi estabelecido pela identificação da mutação I431V no gene do TRβ. Dezesseis parentes assintomáticos da probanda também são afetados pela mutação. Estudos funcionais mostram que a mutação I431V exerce efeito dominante negativo sobre o TR selvagem, basicamente, por prejudicar a liberação do correpressor SMRT ligante-dependente. A presença desta mutação reduz a potência, mas não afeta a eficácia da ação do hormônio tireoideano, o que está de acordo com a apresentação clínica de eumetabolismo dos indivíduos afetados.

Resistance to thyroid hormone (RTH) is a rare disorder characterized by variable tissue hyporesponsiveness to thyroid hormone, usually caused by mutations in the thyroid hormone receptor beta (TRβ). We describe a large Brazilian family harboring a novel mutation affecting TRβ gene and inducing RTH. A 14-year-old girl was found to have elevated free T4 and free T3 plasma concentrations in coexistence with unsuppressed TSH and a questionable goiter. The diagnosis of RTH was verified by identification of a novel mutation (I431V) in the TRβ gene. Sixteen asymptomatic relatives of the proposita are also affected by the mutation. Functional studies showed that I431V mutation exerts dominant-negative effect on wild type TRβ, mainly by impairment of ligand-dependent release of corepressor SMRT. The presence of this mutation reduces potency, but does not affect efficacy of thyroid hormone action, in accordance with the clinical picture of eumetabolism of the affected individuals.

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13.

Síndrome de cushing endógena: características clínico-laboratoriais em 73 casos
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Vilar, Lucio

; Naves, Luciana A.

; Freitas, Maria da Conceição

; Moura, Eliane

; Canadas, Viviane

; Leal, Edmundo

; Teixeira, Luciano

; Gusmão, Amaro

; Santos, Vera

; Campos, Renata

; Lima, Marise

; Paiva, Renata

; Albuquerque, José Luciano

; Egito, Célia S.

; Botelho, Carlos A.

; Lyra, Ruy

; Azevedo, Monalisa F.

; Casulari, Luiz Augusto

Arquivos Brasileiros de Endocrinologia & Metabologia

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jun 2007, Volume 51 N. 4 Pages 566 - 574

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Avaliamos as características clínico-laboratoriais de 73 pacientes com síndrome de Cushing (SC) endógena, assim distribuídos: 46 (63%) com doença de Cushing (DC), 21 (28,7%) com tumores adrenais (TA) e 6 (8,2%) com a síndrome do ACTH ectópico (SAE). A freqüência de manifestações clássicas do hipercortisolismo foi similar, independentemente da etiologia da SC. Em 100% dos casos de SC, observaram-se níveis do cortisol sérico (CS) > 1,8 µg/dL após supressão com doses baixas de dexametasona (DMS), além de elevação do cortisol à meia-noite (sérico ou salivar). Contudo, o cortisol livre urinário foi normal em 11,5% dos pacientes. Os níveis de ACTH mostraram-se suprimidos nos pacientes com TA, normais ou elevados na DC e sempre elevados na SAE. No teste de supressão noturna com 8 mg de DMS, supressão do CS > 50% foi observada em 78,2% dos casos de DC e 33,3% dos casos de SAE, enquanto uma supressão > 80% foi exclusiva da DC. Após estímulo com CRH ou DDAVP, um incremento do ACTH > 35% aconteceu em 81% dos indivíduos com DC e em 16,6% daqueles com SAE, ao passo que um incremento do ACTH > 50% restringiu-se à DC. A combinação de incremento do ACTH > 35 e supressão do CS > 50% foi também exclusiva da DC. A ressonância magnética visualizou 100% dos macroadenomas e 59,4% dos microadenomas hipofisários nos casos de DC. Em 10 pacientes submetidos ao cateterismo bilateral do seio petroso inferior, um gradiente centro-periferia de ACTH > 3 pós-CRH ou DDAVP teve sensibilidade de 90% e especificidade de 100% para a doença de Cushing.

We studied clinical and laboratorial features of 73 patients with endogenous Cushing’s syndrome, subdivided as follows: 46 (63%) with Cushing’s disease (CD), 21 (28.7%) with an adrenal tumor and 6 (8.2%) with ectopic ACTH secretion (EAS). The rate of typical manifestations of hypercortisolism was similar regardless its etiology. In 100% of cases of Cushing’s syndrome we observed serum cortisol levels greater than 1.8 µg/dL in low-dose dexamethasone (DMS) suppression tests, as well as elevation of serum or salivary midnight cortisol. However, urinary free cortisol was normal in 11.5% of patients. ACTH levels were suppressed in patients with adrenal tumors, normal or high in CD and always high in EAS. In the 8-mg overnight DMS suppression test, serum cortisol suppression > 50% was observed in 78.2% of cases of CD and in 33.3% of subjects with EAS, while an 80% suppression was only seen in CD. After stimulation with CRH or DDAVP an ACTH increase > 35% occurred in 81% of individuals with CD and 16.6% of those with EAS, while an ACTH increase > 50 achieved 100% specificity. Moreover, the combination of serum cortisol suppression > 50% and an ACTH increase > 35% in both tests only occurred in Cushing’s disease. Pituitary magnetic resonance imaging identified 100% of macroadenomas and 59.4% of microadenomas in patients with CD. Among 10 patients that underwent bilateral inferior petrosal sinus sampling, a central-to-peripheral ACTH gradient > 3 after CRH or DDAVP had 90% sensitivity and 100% specificity for Cushing’s disease.

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14.

Prevalência da macroprolactinemia entre 115 pacientes com hiperprolactinemia
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Vilar, Lucio

; Moura, Eliane

; Canadas, Viviane

; Gusmão, Amaro

; Campos, Renata

; Leal, Edmundo

; Teixeira, Luciano

; Santos, Vera

; Gomes, Barbara

; Lima, Marise

; Paiva, Renata

; Albuquerque, José Luciano

; Egito, Célia S.

; Botelho, Carlos A.

; Azevedo, Monalisa

; Casulari, Luiz Augusto

; Naves, Luciana A.

Arquivos Brasileiros de Endocrinologia & Metabologia

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feb 2007, Volume 51 N. 1 Pages 86 - 91

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Macroprolactinemia caracteriza-se pelo predomínio no soro de uma prolactina (PRL) de alto peso molecular e baixa atividade biológica que não requer tratamento. A prevalência de macroprolactinemia foi avaliada em 115 pacientes consecutivos com hiperprolactinemia. Entre eles, 19 (16,5%) tinham exclusivamente macroprolactinemia, 4 (3,5%) síndrome dos ovários policísticos, 7 (6,1%) acromegalia, 8 (6,9%) hiperprolactinemia idiopática, 10 (8,7%) hipotiroidismo primário, 14 (12,2%) adenomas clinicamente não-funcionantes, 20 (17,4%) hiperprolactinemia farmacológica e 33 (28,7%) prolactinomas. O diagnóstico de macroprolactinemia foi estabelecido pela obtenção de uma recuperação da PRL < 30% após tratamento do soro com polietilenoglicol. Dentre os 19 pacientes com macroprolactinemia isolada, 16 (84,2%) eram mulheres e 12 (63,2%) eram assintomáticos, enquanto 4 (21%) tinham oligomenorréia e 3 (15,8%), galactorréia. Em contraste, apenas 11,5% dos indivíduos com outras causas de hiperprolactinemia eram assintomáticos (p< 0,001). Os níveis de PRL nos casos de macroprolactinemia variaram de 45,1 a 404 ng/mL (média de 113,3 ± 94,5), mas em 15 (78,9%) foram < 100 ng/mL. Nossos achados demonstram que macroprolactinemia é uma condição freqüente e, assim, sugerimos que seja rotineiramente pesquisada em pacientes com hiperprolactinemia.

Macroprolactinemia is characterized by the predominance in the serum of macroprolactin, a prolactin (PRL) with high molecular mass and low biological activity that does not need treatment. The prevalence of macroprolactinemia was evaluated in 115 consecutive patients with hyperprolactinemia. Among them, 19 (16.5%) had solely macroprolactinemia, 4 (3.5%) polycystic ovary syndrome, 7 (6.1%) acromegaly, 8 (6.9%) idiopathic hyperprolactinemia, 10 (8.6%) primary hypothyroidism, 14 (12.2%) clinically non-functioning pituitary adenomas, 20 (17.4%) drug-induced hyperprolactinemia and 33 (28.7%) prolactinomas. The diagnosis of macroprolactinemia was established by the demonstration of a PRL recovery < 30% after treatment of sera with polyethylene glycol. Among the 19 patients with isolated macroprolactinemia, 16 (84.2%) were female and 12 (63.2%) were asymptomatic, while 4 (21%) presented with oligomenorrhea and 3 (15.8%) with galactorrhea. In contrast, only 11.5% of individuals with other causes of hyperprolactinemia were asymptomatic (p< 0.001). Prolactin levels in cases of macroprolactin ranged from 45.1 to 404 ng/mL (mean 113.3 ± 94.5) but in 15 (78.9%) were < 100 ng/mL. Our findings demonstrate that macroprolactinemia is a common condition and, therefore, we suggest that it should be routinely screened in patients with hyperprolactinemia.

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15.

Incidentalomas hipofisários
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Vilar, Lucio

; Azevedo, Monalisa F.

; Barisic, Gilka

; Naves, Luciana A.

Arquivos Brasileiros de Endocrinologia & Metabologia

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oct 2005, Volume 49 N. 5 Pages 651 - 656

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Lesões hipofisárias clinicamente inaparentes são demonstradas através da ressonância magnética em aproximadamente 10% da população geral adulta, caracterizando os chamados incidentalomas hipofisários. A história natural dessas lesões ainda não está completamente estabelecida. Embora sejam tipicamente pequenos (< 10mm no seu maior diâmetro) e clinicamente silenciosos, alguns incidentalomas hipofisários podem secretar hormônios ou causar efeitos de massa por compressão sobre estruturas vizinhas. Além disso, uma minoria dessas lesões, principalmente aquelas com mais de 10mm (macroincidentalomas) podem crescer com o tempo; assim, o seguimento a longo prazo se faz necessário. Intervenções terapêuticas estão indicadas para os incidentalomas funcionantes (uso de agonistas dopaminérgicos ou ressecção transesfenoidal) ou para aqueles que causem efeitos de massa ou aumentem de tamanho durante o seguimento (ressecção transesfenoidal). Significante extensão supra-selar ou hipopituitarismo podem ser indicações adicionais para o tratamento cirúrgico, mesmo na ausência de compressão quiasmática.

Clinically unsuspected pituitary lesions are demonstrated by magnetic resonance imaging in approximately 10% of the general adult population, characterizing the so-called pituitary incidentalomas. Their natural history is not yet completely established. Despite being typically small (<10mm in the greatest diameter) and clinically silent, some pituitary incidentalomas may be hormonally active or cause mass effects by compressing neighboring structures. Furthermore, a minority of these lesions, particularly those greater than 10mm (macroincidentalomas) may grow over time; hence, longterm follow-up is necessary. Therapeutic interventions are indicated for lesions that are hormonally active (use of dopamine agonists or transsphenoidal resection) or for those that cause mass effects or increase in size during the follow-up (transsphenoidal resection). Significant suprasellar extension or hypopituitarism may be additional indications for surgical treatment even in the absence of chiasm compression.

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