The centralization of care for patients with sickle cell diseases through the creation of reference centers through the Ministry of Health Ordinance No. 1,018/2005, enabled better monitoring of these patients. This study characterized the sociodemographic and clinical profile of patients with sickle cell diseases treated at reference centers in the city of Salvador. Women represented the largest portion of patients registered at the centers and were older and more educated than men. More than 90.0% of patients are single, demonstrating the difficulty of people with sickle cell disease to socialize due to the stigma of the disease. The most common clinical manifestations were pain crises and jaundice, and the most common complications were hospitalizations due to pain crises and blood transfusion. Associations were observed between sex and stroke, between genotype and lower limb ulcers and blood transfusion. A low percentage of patients with osteonecrosis (8.8%) was also observed, indicating possible underreporting. The low percentages of patients who use morphine and hydroxyurea point to the need to expand the offer of these drugs to reduce pain crises and improve the quality of life of patients.

La centralización de la atención a los pacientes con anemia falciforme mediante la creación de centros de referencia a través de la Ordenanza del Ministerio de Salud Nº 1.018 / 2005, permitió un mejor seguimiento de estos pacientes. Este estudio caracterizó el perfil sociodemográfico y clínico de los pacientes con drepanocitosis atendidos en centros de referencia de la ciudad de Salvador. Las mujeres representaban la mayor parte de los pacientes registrados en los centros y eran mayores y tenían más educación que los hombres. Más del 90,0% de los pacientes son solteros, lo que demuestra la dificultad de las personas con anemia falciforme para socializar debido al estigma de la enfermedad. Las manifestaciones clínicas más frecuentes fueron crisis de dolor e ictericia, y las complicaciones más frecuentes fueron hospitalizaciones por crisis de dolor y transfusión de sangre. Se observaron asociaciones entre sexo y accidente cerebrovascular, entre genotipo y úlceras de miembros inferiores y transfusión de sangre. También se observó un bajo porcentaje de pacientes con osteonecrosis (8,8%), lo que indica un posible subregistro. Los bajos porcentajes de pacientes que utilizan morfina e hidroxiurea apuntan a la necesidad de ampliar la oferta de estos fármacos para reducir las crisis de dolor y mejorar la calidad de vida de los pacientes.

A centralização do atendimento dos pacientes com doenças falciformes através da criação de centros de referência possibilitou um melhor acompanhamento desses pacientes. Este estudo caracterizou o perfil sociodemográfico e clínico dos pacientes com doenças falciformes atendidos nos centros de referência no município de Salvador. Os resultados deste estudo corroboram com a literatura e podem ajudar a melhorar os serviços oferecidos nos centros de referência pesquisados. As mulheres representaram a maior parcela dos pacientes registrados nos centros e com maior faixa etária e escolaridade do que os homens. Mais de 90,0% dos pacientes são solteiros, demonstrando a dificuldade das pessoas com doenças falciformes se socializarem devido ao estigma da doença. As manifestações clínicas mais comuns foram as crises álgicas e a icterícia e as intercorrências mais comuns foram internações devido as crises álgicas e hemotransfusão. Foram observadas associações entre sexo e acidente vascular cerebral, entre o genótipo e úlceras de membros inferiores e hemotransfusão. Também foi observado um percentual baixo de pacientes com osteonecrose indicando possível subnotificação. Os percentuais baixos de pacientes que fazem uso da morfina e hidroxiureia apontam para a necessidade de ampliar a oferta desses medicamentos para diminuir as crises álgicas e melhorar a qualidade de vida dos pacientes.

ABSTRACT Butia capitata (Mart.) Becc. or "coquinho azedo" is a native palm species of the Brazilian savannah, bears fruits which are sold fresh or as frozen pulp. This study examined postharvest changes in "coquinho azedo" harvested at a commercially immature stage and later evaluated the quality of these fruits by comparing them with those harvested fully ripe. Fruits purchased in the 2020 harvest in Santo Antônio do Retiro, MG (Brazil), were harvested at different degrees of maturity, namely, commercially immature and ripe, according to the point of harvest adopted in the region. For 7 d, weight loss, skin color and respiratory activity were evaluated in the commercially immature-harvested fruits. At 7 d postharvest, physical and chemical evaluations of the pulp were performed. The ripe-harvested fruits were subjected to the same evaluations, but only at 1 d postharvest. The skin color of commercially immature-harvested fruits tended to yellow over the days. Respiration postharvest increased in the immature-harvested fruits. Fresh weight loss exceeded 10% but without compromising appearance. The commercially immature-harvested fruits had 55% more total phenols, whereas the ripe-harvested fruits had higher soluble solids and ascorbic acid contents. Pulp color, soluble solids/titratable acidity ratio and total carotenoid contents were similar regardless of the degree of maturity at harvest. During the days after the harvest of the commercially immature "coquinho azedo", changes take place which cause them to resemble the fruit harvested ripe. Based on the evaluated traits, the early harvest did not compromise the ripening of the fruits.

RESUMEN Butia capitata (Mart.) Becc. o "coquinho azedo" es una especie de palma nativa de la flora brasilefla, produce frutos que se venden frescos o como pulpa congelada. Este estudio examino los cambios poscosecha en los frutos de "coquinho azedo" recolectados en su etapa comercialmente inmaduros y evaluó su calidad comparándola con los cosechados completamente maduros. Los frutos adquiridos en la cosecha de 2020 en Santo Antonio do Retiro, MG (Brasil), fueron cosechados en diferentes grados de madurez: inmaduros o maduros según el punto de cosecha adoptado en la región. Durante 7 d, se evaluó la pérdida de peso, el color de la epidermis y la actividad respiratoria en los frutos inmaduros recolectados. A los 7 d poscosecha, se realizaron evaluaciones físicas y químicas de la pulpa. Los frutos cosechados maduros fueron sometidos a las mismas evaluaciones, pero 1 d después de recolectados. El color de la epidermis de los frutos inmaduros tendió a amarillearse con el paso de los días. La respiración poscosecha aumentó en los frutos inmaduros. La pérdida de peso fresco superó el 10%, pero sin comprometer la apariencia. Los frutos cosechados inmaduros tuvieron un 55% más de fenoles totales, mientras que los maduros tuvieron mayores niveles de sólidos solubles y ácido ascòrbico. El color de la pulpa, la relación solidos solubles/ acidez titulable y el contenido de carotenoides totales fueron similares independiente del estado de madurez en la cosecha. Durante los días posteriores a la cosecha del "coquinho azedo" comercialmente inmaduro, ocurren cambios que los hacen similares a los cosechados maduros. Con base en las características evaluadas, la anticipación de la cosecha no comprometió la maduración de los frutos.

Resumo Objetivou-se avaliar o efeito de diferentes níveis de adubação potássica no crescimento inicial de clones de palma forrageira (Nopalea cochenillifera Salm Dyck). O experimento foi conduzido durante seis meses, disposto em delineamento em blocos ao acaso, em esquema fatorial 5x2, sendo cinco níveis de adubação potássica (0, 250, 500, 750 e 1000 Kg de K2O ha-1) e dois clones de palma forrageira (Doce Gigante e Doce Miúda), com quatro repetições. Foi plantado um cladódio por vaso (unidade experimental) com capacidade para 7 kg de solo (24 x 17 x 23 cm). Ao longo do período experimental, foram avaliadas as características estruturais das plantas, tais como altura e largura de planta, comprimento, largura, espessura e perímetro de cladódio, bem como contabilização do número de cladódios total e por ordem de surgimento. Ao final do experimento avaliou-se a biomassa, para determinação do rendimento de massa fresca (MV) e seca (MS) da parte aérea e do sistema radicular. Após a determinação de MS, determinou-se o teor potássico nos tecidos vegetais. Os dados foram submetidos a ANOVA e, caso necessário, ao teste de Tukey a 5% de significância. A adubação potássica e os clones de palma forrageira não exerceram influências significativas nas variáveis avaliadas durante a condução experimental. A adubação potássica não influencia as características estruturais, produtivas e teor potássico no crescimento inicial de clones de Nopalea cochenillifera.

Abstract The objective was to evaluate the effect of different levels of potassium fertilization on the initial growth of forage cactus (Nopalea cochenillifera Salm Dyck) clones. The experiment lasted six months, arranged in a randomized block design, in a 5 x 2 factorial scheme, with five levels of potassium fertilization (0, 250, 500, 750, and 1,000 kg of K2O ha-1) and two forage cactus clones (Little Sweet and Giant Sweet), with four replicates. One cladode was planted per pot (experimental unit) with a capacity of 7 kg of soil (24 x 17 x 23 cm). During the experimental period, the plants' structural characteristics were evaluated, such as plant height and width, length, width, thickness, and perimeter of the cladode, as well as accounting for the number of total cladodes, and in order of appearance. At the end of the experiment, biomass was evaluated to determine the fresh matter (FM) and dry matter (DM) yield of the aerial part and the root system. After determining the DM, the potassium content in the plant tissues was determined. The data were submitted to ANOVA and, if necessary, to the Tukey test at a 5% significance level. The potassium fertilization and the forage palm clones did not exert influences based on the variables evaluated during the experimental conduction. Potassium fertilization does not influence the structural and productive characteristics and the potassium content in the N. cochenillifera clones' initial growth.

Durante as últimas décadas, o mundo passou por uma transformação demográfica, com um rápido crescimento da população idosa e, portanto, tanto a demanda para a manutenção da saúde deste grupo populacional, quanto o consumo de medicamentos estão aumentando. Ainda, as mudanças farmacocinéticas e farmacodinâmicas que ocorrem em idosos podem interferir diretamente nos efeitos adversos dos medicamentos e aumentar o risco de intoxicação. Além disso, há fatores externos que interferem na farmacoterapia dos idosos, tais como o uso inadequado e a falta de acesso à informação. Existem várias classes terapêuticas de medicamentos que devem ser utilizados com cautela ou evitados na população idosa, tais como antiinflamatórios, alguns anti-hipertensivos, diuréticos, digitálicos entre outros. Estes medicamentos, se não forem utilizados com cuidado, podem afetar a qualidade de vida e a segurança desta população. Assim, este trabalho visa identificar medicamentos que devem ser utilizados com cuidado em pacientes idosos para evitar intoxicações e/ou eventos adversos aos medicamentos.

In recent decades, the world has undergone a demographic transformation with a rapid growth of the elderly population, resulting in an increased demand for funds to maintain their health and drug consumption. Pharmacokinetic and pharmacodynamic changes occurring in the elderly can interfere directly in the adverse effects of drugs and increase the risk of intoxication. In addition, there are external factors interfering with the pharmacotherapy of the elderly, such as inappropriate use and the lack of access to information. Many therapeutic classes of drugs should be used with caution or avoided in the elderly population, such as anti-inflammatory and some anti-hypertensive drugs, diuretics and digitalis. If not managed carefully, these medicines can affect the safety and quality of life in the elderly. Thus, the aim of this review was to identify drugs that should be used with caution in elderly patients in order to avoid intoxication and/or adverse drug events.

The common everyday use of medicinal plants is an ancient, and still very widespread practice, whereby the need for studies on their possible toxicity and mutagenic properties. The species Coccoloba mollis has been much used in phytotherapy, mainly in cases involving loss of memory and stress. In order to investigate its genotoxic and mutagenic potential, ethanolic extracts from the leaves and roots underwent Salmonella/microsome assaying (TA98 and TA100 strains, with and without exogenous metabolism - S9), besides comet and micronucleus tests in vivo.There was no significant increase in the number of revertants/plate of Salmonella strains in any of the analyzed root-extract concentrations, although the extract itself was extremely toxic to the Salmonella TA98 strain in the tests carried out with S9 (doses varying from 0.005 to 0.5 µg/plate). On the other hand, the leaf-extract induced mutations in the TA98 strain in the absence of S9 in the highest concentration evaluated, although at very low mutagenic potency (0.004 rev/µg). Furthermore, there was no statistically significant increase in the number of comets and micronuclei, in treatments involving Swiss mice. It was obvious that extracts of Coccoloba mollis, under the described experimental conditions, are not mutagenic.

Urinalysis of acetone is important to monitor workers occupationally exposed to acetone and/or isopropanol, as well as in diagnosis of some diseases related to lipid metabolism impairment. This work shows a sensitive, simple and rapid static headspace-gas chromatographic procedure for quantitative determination of acetone in urine. The method was applied to measure acetone in 207 samples from general population volunteers, resulting in a mean level of 1.12 mg/L (± 0.47) and a range of 0.20 - 1.95 mg/L. The method is reproducible and reliable, making it suitable for routine analysis of acetone in urine.