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A bullous variant of central serous chorioretinopathy treated with oral spironolactone
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Isaac, David Leonardo Cruvinel

; Lando, Leonardo

; Silva, Hugo Mendes

; Avila, Marcos P.

Arquivos Brasileiros de Oftalmologia

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jul 2023, Volume 86 N. 4 Pages 375 - 379

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT We report the case of a 39-year-old male patient who presented with visual loss in the right eye for 6 weeks. The best-corrected visual acuity was counting fingers in the right eye and 20/30 in the left eye. The fundus examination demonstrated a right retinal detachment inferiorly extending to the fovea and a left macular serous detachment. After multimodal imaging study, the patient was diagnosed as having a bullous variant of central serous chorioretinopathy and treated with oral spironolactone associated with adjuvant laser photocoagulation. The retinal changes resolved after 6 months. The final visual acuity was 20/20 in both eyes.

RESUMO Relatamos o caso de um homem de 39 anos apresentando perda visual no olho direito há seis semanas. A melhor acuidade visual corrigida foi conta-dedos no olho direito e 20/30 no esquerdo. A fundoscopia demonstrou descolamento de retina direito inferiormente com extensão à fóvea e descolamento macular seroso à esquerda. Após estudos de imagem multimodal, o paciente foi diagnosticado com uma variante bolhosa de coriorretinopatia serosa central e tratado com espironolactona oral associada à fotocoagulação a laser adjuvante. As alterações retinianas resolveram após seis meses. A acuidade visual final foi 20/20 em ambos os olhos.

https://doi.org/10.5935/0004-2749.20230033

O conceito de experiência em Dewey e Gadamer e as suas implicações para a formação
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Torres Santana, Anthony Fábio

; Colla, Rodrigo Avila

; Pereira, Marcos Villela

Revista Portuguesa de Educação

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jun 2022, Volume 35 N. 1 Pages 208 - 225

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo Este artigo tem como objetivo investigar o conceito de experiência na filosofia de Dewey e Gadamer, bem como suas implicações para a formação. Sendo assim, a questão que nos move é: quais os efeitos da experiência no processo de formação? Atualmente, muito se fala sobre experiência e formação, e advém desse contexto a necessidade de tecermos um olhar cuidadoso acerca das nuances que estão compondo esses conceitos, sobretudo no campo da Educação. Para isso, desenvolvemos um estudo de natureza qualitativa, que tem como aporte metodológico a pesquisa bibliográfica. Neste prisma, ao buscarmos criar um mapa teórico visitando tradições distintas, compomos o referencial que embasa esta pesquisa, instrumentalizando-nos com a leitura de: Gallo, Heidegger, Hermann, Kneller, Kuhn, Trevisan e, principalmente, Dewey e Gadamer. Dessa forma, apresentamos como resultado a compreensão de que, seja um acontecimento extraordinário ou algo simples, experiência é tudo aquilo que altera o modo de pensar e/ou agir do sujeito, passando a constituí-lo de modo diferente, portanto, a formá-lo.

RESUMEN Este artículo tiene como objetivo investigar el concepto de experiencia en la filosofía de Dewey y Gadamer, así como sus implicaciones para la formación. Por lo tanto, la pregunta que nos mueve es: ¿cuáles son los efectos de la experiencia en el proceso de formación? Actualmente, se habla mucho de la experiencia, de la formación y, en este contexto, surge la necesidad de analizar los matices que componen estos conceptos, especialmente en el campo de la Educación. Para ello, desarrollamos un estudio de naturaleza cualitativa, cuyo soporte metodológico es la investigación bibliográfica. Bajo este prisma, cuando buscamos crear un mapa teórico visitando diferentes tradiciones, componemos el marco referencial en el cual está basada la presente investigación, instrumentalizándonos con la lectura de: Gallo, Heidegger, Hermann, Kneller, Kuhn, Trevisan y, especialmente, Dewey y Gadamer. De esta forma, presentamos como resultado la comprensión de que, sea un evento extraordinario o algo simple, la experiencia es todo lo que cambia la forma de pensar y/o actuar del sujeto, comenzando a constituirlo de manera diferente, formándolo.

ABSTRACT This article aims to investigate the concept of experience in the philosophy of Dewey and Gadamer, as well as its implications for formation. Therefore, the question that moves us is: what are the effects of experience on the formation process? Currently, much is said about experience and formation, and from this context comes the need to take a careful look at the elements that are composing these concepts, especially in the field of Education. This is a qualitative study, whose methodological support is the bibliographic research. In this sense, when we seek to create a theoretical map visiting different traditions, we compose the framework that underlies this research, instrumentalizing us with the reading of: Gallo, Heidegger, Hermann, Kneller, Kuhn, Trevisan and, especially, Dewey and Gadamer. Thus, we present as a result the understanding that, be it an extraordinary event or something simple, experience is everything that changes the way of thinking and/or acting of the subject, starting to constitute it differently, therefore forming it.

https://doi.org/10.21814/rpe.18881 5 downloads

Estratégias Econômicas e Sociais para Anticoagulação de Pacientes com Fibrilação Atrial
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Guerrero, Andressa Zulmira Avila

; Coutinho, Enia Lucia

; Ferraz, Marcos Bosi

; Cirenza, Claudio

; Santos, Marcelo Cincotto Esteves dos

; Ferraro, José Roberto

; Paola, Angelo Amato Vincenzo de

Arquivos Brasileiros de Cardiologia

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jan 2022, Volume 118 N. 1 Pages 88 - 94

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: A fibrilação atrial é um problema de saúde pública associado com um risco cinco vezes maior de acidente vascular cerebral e mortalidade. A análise de custos é importante para a introdução de novas terapias, e deve ser reconsiderada em situações especiais, tais como a pandemia do coronavírus em 2020. Objetivo: Avaliar os custos (em um período de um ano) relacionados à terapia anticoagulante e a qualidade de vida de pacientes com fibrilação atrial tratados em um hospital público universitário. Métodos: Os custos do paciente foram aqueles relacionados à anticoagulação e calculados pela média de custos mensais da varfarina ou de anticoagulantes orais diretos (DOACs). As despesas não médicas, como alimentação e transporte, foram calculadas a partir de dados obtidos de questionários. O questionário brasileiro SF-6D foi usado para medir a qualidade de vida. Valores p<0,05 foram considerados estatisticamente significativos. Resultados: A população do estudo consistiu em 90 pacientes, 45 em cada braço (varfarina vs. DOACs). Os custos foram 20% mais altos no grupo dos DOACs (US$55 532,62 vs. US$46 385,88), e principalmente relacionados ao preço dos medicamentos (US$23 497,16 vs. US$1903,27). Os custos hospitalares foram mais altos no grupo da varfarina (US$31 088,41 vs $24 604,74), e relacionados às visitas ao ambulatório. Ainda, as despesas não médicas foram duas vezes maiores no grupo varfarina ($13 394,20 vs $7 430,72). A equivalência de preço entre os dois medicamentos seria alcançada por uma redução de 39% no preço dos DOACs. Não foram observadas diferenças quanto à qualidade de vida. Conclusões: Os custos totais foram mais altos no grupo de pacientes tratados com DOACs que no grupo da varfarina. No entanto, uma redução de cerca de 40% no preço dos DOACs tornaria viável a incorporação desses medicamentos no sistema de saúde público brasileiro.

Abstract Background: Atrial fibrillation is a public health problem associated with a fivefold increased risk of stroke or death. Analyzing costs is important when introducing new therapies and must be reconsidered in special situations, such as the novel coronavirus pandemic of 2020. Objective: This study aimed to evaluate the costs related to anticoagulant therapy in a one-year period, and the quality of life of atrial fibrillation patients treated in a public university hospital. Methods: Patient costs were those related to the anticoagulation and calculated by the average monthly costs of warfarin or direct oral anticoagulants (DOACs). Patient non-medical costs (eg., food and transportation) were calculated from data obtained by questionnaires. The Brazilian SF-6D was used to measure the quality of life. P-values < 0.05 were considered statistically significant. Results: The study population consisted of 90 patients, 45 in each arm (warfarin vs direct oral anticoagulants). Costs were 20% higher in the DOAC group ($55,532.62 vs $46,385.88), and mainly related to drug price ($23,497.16 vs $1,903.27). Hospital costs were higher in the warfarin group ($31,088.41 vs $24,604.74) and related to outpatient visits. Additionally, non-medical costs were almost twice higher in the warfarin group ($13,394.20 vs $7,430.72). Equivalence of price between the two drugs could be achieved by a 39% reduction in the price of DOACs. There were no significant group differences regarding quality of life. Conclusions: Total costs were higher in the group of patients taking DOACs than those taking warfarin. However, a nearly 40% reduction in the price of DOACs could make it feasible to incorporate these drugs into the Brazilian public health system.

https://doi.org/10.36660/abc.20200921

A bullous variant of central serous chorioretinopathy treated with oral spironolactone
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Isaac, David Leonardo Cruvinel

; Lando, Leonardo

; Silva, Hugo Mendes

; Avila, Marcos P.

Arquivos Brasileiros de Oftalmologia

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2022, N. ahead

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5935/0004-2749.20230033

Diretriz de Miocardites da Sociedade Brasileira de Cardiologia – 2022
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Montera, Marcelo Westerlund

; Marcondes-Braga, Fabiana G.

; Simões, Marcus Vinícius

; Moura, Lídia Ana Zytynski

; Fernandes, Fabio

; Mangine, Sandrigo

; Oliveira Júnior, Amarino Carvalho de

; Souza, Aurea Lucia Alves de Azevedo Grippa de

; Ianni, Bárbara Maria

; Rochitte, Carlos Eduardo

; Mesquita, Claudio Tinoco

; de Azevedo Filho, Clerio F.

; Freitas, Dhayn Cassi de Almeida

; Melo, Dirceu Thiago Pessoa de

; Bocchi, Edimar Alcides

; Horowitz, Estela Suzana Kleiman

; Mesquita, Evandro Tinoco

; Oliveira, Guilherme H.

; Villacorta, Humberto

; Rossi Neto, João Manoel

; Barbosa, João Marcos Bemfica

; Figueiredo Neto, José Albuquerque de

; Luiz, Louise Freire

; Hajjar, Ludhmila Abrahão

; Beck-da-Silva, Luis

; Campos, Luiz Antonio de Almeida

; Danzmann, Luiz Cláudio

; Bittencourt, Marcelo Imbroinise

; Garcia, Marcelo Iorio

; Avila, Monica Samuel

; Clausell, Nadine Oliveira

; Oliveira Jr, Nilson Araujo de

; Silvestre, Odilson Marcos

; Souza, Olga Ferreira de

; Mourilhe-Rocha, Ricardo

; Kalil Filho, Roberto

; Al-Kindi, Sadeer G.

; Rassi, Salvador

; Alves, Silvia Marinho Martins

; Ferreira, Silvia Moreira Ayub

; Rizk, Stéphanie Itala

; Mattos, Tiago Azevedo Costa

; Barzilai, Vitor

; Martins, Wolney de Andrade

; Schultheiss, Heinz-Peter

Arquivos Brasileiros de Cardiologia

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2022, Volume 119 N. 1 Pages 143 - 211

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220412

Puentes entre la universidad y el territorio: herramientas al servicio de productores en transición agroecológica en el departamento Banda, Santiago del Estero
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Avila, Andrea Alejandra

; Rueda, Carla Vanezza

; Rueda, Marta Patricia

; Gómez, Adriana Teresita

Revista de extensión universitaria

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dec 2021, N. 15 Pages 26 - 26

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo Este trabalho descreve a experiência de articulação entre o Projeto de Extensão “Certificação Agroecológica Participativa” e uma Prática Profissional Supervisionada da Universidade Nacional de Santiago del Estero, Argentina, a partir de uma abordagem participativa de aprendizagem e vinculação. O trabalho teve três etapas: 1-desenvolvimento da estrutura conceitual, 2- construção do sistema agroecológico e 3-obtenção de um mapa preliminar dos principais atores. A estrutura conceitual dos Sistemas Participativos de Garantia foi o novo espaço de trabalho mais adequado para a transição agroecológica. A abordagem sistêmica com técnicas participativas permite conhecer o modelo e quantificar as entradas e saídas do sistema, e fundamenta o protocolo de garantia da produção agroecológica. A rede de atores foi construída para a construção da identidade agroecológica. Os resultados se divulgaram em relatórios, trabalhos em congressos, divulgação e oficinas de retribuição à comunidade. As ferramentas metodológicas e os novos referenciais teóricos adequados à realidade do território de vinculação enriqueceram a experiência de aprendizagem.

Resumen Este trabajo describe la experiencia de articulación entre el Proyecto de Extensión Certificación Participativa Agroecológica y una Práctica Profesional Supervisada de la Universidad Nacional de Santiago del Estero (UNSE), Argentina, desde un enfoque de vinculación y aprendizaje participativo. Tuvo 3 etapas: 1) desarrollo del marco conceptual, 2) construcción del sistema agroecológico, y 3) obtención de mapa preliminar de actores claves. Mediante el marco conceptual, se decidió continuar con sistemas participativos de garantía como espacio de trabajo más eficaz para la transición agroecológica. El enfoque de sistemas con técnicas participativas permite conocer el modelo y cuantificar las entradas y salidas del sistema y aporta las bases para el protocolo de garantía de la producción agroecológica. Se construyó la red de actores para la construcción de la identidad agroecológica. Los resultados se publicaron en informes, trabajo a congresos, divulgación y talleres de devolución a la comunidad. Las herramientas metodológicas y los nuevos marcos teóricos apropiados a la realidad del territorio de vinculación enriquecieron la experiencia de aprendizaje.

Abstract This work describes the experience of articulation between the Extension Project “Agroecological Participatory Certification” and a Supervised Professional Practice of the National University of Santiago del Estero, from a participatory learning and linkage approach.The work had 3 stages: 1) development of conceptual framework, 2) construction of agroecological system and 3) obtaining a preliminary map of stakeholders.Was found conceptual framework of Participatory Guarantee Systems as new and most effective workspace for the agroecological transition. The systems approach with participatory techniques allows knowing the model and quantifying the inputs and outputs of the system; and provides the basis for the protocol for the guarantee of agroecological production. The network of actors was builted for construction of the agroecological identity. The results were published in reports, work at conference proceeding, outreach and community interaction workshops. The methodological tools and the new theoretical frameworks appropriate to the reality of the linking territory, enriched the learning experience.

https://doi.org/10.14409/extension.2021.15.jul-dic.e0012

Volume Measurement System Based on Hall Effect Sensors Circularly Coupled and Arranged in a Quadrature Shape
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Martínez Espinosa, Juan Carlos

; Ortiz Alvarado, Juan de Dios

; Córdoba Valdes, Fidel

; Rodriguez Martinez, Marcos Alberto

; Fuentes Avila, Marcos Leonardo

; Guzmán Cabrera, Rafael

Computación y Sistemas

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jun 2021, Volume 25 N. 2 Pages 417 - 422

Abstract: En | Text: En | PDF: En

Abstract In this research work, a compact electronic system for measuring volumes in generic cylindrical containers was designed and developed. The system is based on a circular arrangement composed of four Hall effect sensors A1324 and arranged in the form of a quadrature. The theoretical volume calculations obtained based on the angle of inclination of the float for a cylindrical container were correlated with a polynomial function of order 3 with an R2 = 0.99. The analog voltage signal correlated with the theoretical volume was digitized through a microcontroller and a ZigBee transceiver was used as a data transmission channel and through a ZigBee Xbee ZB24 transceiver was used for information transfer. The experimental and theoretical results obtained corroborate a highly accurate and reliable measurement system, which can be applied to different containers and different types of fluids that are to be monitored remotely. Finally based on the theoretical model, this system could be scaled to cylindrical containers of greater capacity without modifying the conditions of the electronic system with the array of Hall effect sensors.

https://doi.org/10.13053/cys-25-2-3904 27 downloads

Atualização de Tópicos Emergentes da Diretriz Brasileira de Insuficiência Cardíaca – 2021
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Marcondes-Braga, Fabiana G.

; Moura, Lídia Ana Zytynski

; Issa, Victor Sarli

; Vieira, Jefferson Luis

; Rohde, Luis Eduardo

; Simões, Marcus Vinícius

; Fernandes-Silva, Miguel Morita

; Rassi, Salvador

; Alves, Silvia Marinho Martins

; Albuquerque, Denilson Campos de

; Almeida, Dirceu Rodrigues de

; Bocchi, Edimar Alcides

; Ramires, Felix José Alvarez

; Bacal, Fernando

; Rossi Neto, João Manoel

; Danzmann, Luiz Claudio

; Montera, Marcelo Westerlund

; Oliveira Junior, Mucio Tavares de

; Clausell, Nadine

; Silvestre, Odilson Marcos

; Bestetti, Reinaldo Bulgarelli

; Bernadez-Pereira, Sabrina

; Freitas Jr, Aguinaldo F.

; Biolo, Andréia

; Barretto, Antonio Carlos Pereira

; Jorge, Antônio José Lagoeiro

; Biselli, Bruno

; Montenegro, Carlos Eduardo Lucena

; Santos Júnior, Edval Gomes dos

; Figueiredo, Estêvão Lanna

; Fernandes, Fábio

; Silveira, Fabio Serra

; Atik, Fernando Antibas

; Brito, Flávio de Souza

; Souza, Germano Emílio Conceição

; Ribeiro, Gustavo Calado de Aguiar

; Villacorta, Humberto

; Souza Neto, João David de

; Goldraich, Livia Adams

; Beck-da-Silva, Luís

; Canesin, Manoel Fernandes

; Bittencourt, Marcelo Imbroinise

; Bonatto, Marcely Gimenes

; Moreira, Maria da Consolação Vieira

; Avila, Mônica Samuel

; Coelho Filho, Otavio Rizzi

; Schwartzmann, Pedro Vellosa

; Mourilhe-Rocha, Ricardo

; Mangini, Sandrigo

; Ferreira, Silvia Moreira Ayub

; Figueiredo Neto, José Albuquerque de

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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jun 2021, Volume 116 N. 6 Pages 1174 - 1212

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210367 3168 downloads

Territorialidade e desastre: a gestão dos desastres no Brasil com base no estudo de caso da Defesa Civil em Santa Catarina
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Joner, Késia

; Avila, Maria Roseli Rossi

; Mattedi, Marcos Antonio

urbe. Revista Brasileira de Gestão Urbana

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2021, Volume 13 elocation e20200061

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O artigo aborda a gestão dos desastres a partir do estudo de caso da Defesa Civil de Santa Catarina. Argumenta que quanto maior a centralização e tecnificação, menor a coordenação e mais burocrática a gestão. A burocratização resulta em uma atuação mais voltada à Gestão dos Desastres (GD) do que à Gestão do Risco de Desastres (GRD) como preconizam o Marco de Ação de Hyogo e o Marco de Sendai. Com a centralização e a tecnificação, fases importantes da GRD como a participação social e comunitária nos processos decisórios são ignoradas, bem como o conhecimento científico e os saberes locais. Estes últimos, premissas importantes para a GRD pois atuam no fortalecimento da resiliência de um sistema ou comunidade.

Abstract The article addresses the issue of disaster management from the case study of Civil Defense of Santa Catarina. It argues that the greater the centralization and technification, the less coordinated and more bureaucratic management becomes. Bureaucratization leads to Disaster Management (DM) instead of Disasters Risk Management (DRM) as advocated by the Hyogo Mark for Action and the Sendai Mark. Important phases of DRM such as community participation and decision-making processes are ignored, as well as the scientific knowledge and local knowledge. These knowledges, important premises for DRM since they act in the resilience reinforcement of a system or community.

https://doi.org/10.1590/2175-3369.013.e20200061 71 downloads

10.

Abordagens de aprendizado e sua correlação com ambiente educacional e características individuais em escola médica
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Rossi, Giulia Zanata

; Fischer, João Marcos da Silva

; Rocha, Sheyla Ribeiro

; Casalecchi, Gabriel Avila

; Avó, Lucimar da Silva Retto de

; Germano, Carla Maria Ramos

Revista Brasileira de Educação Médica

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2021, Volume 45 N. 3 elocation e169

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Introdução: A qualidade de aprendizado de estudantes de escolas médicas tem sido tema recorrente da literatura mundial nas últimas décadas, mas há escassez de estudos nacionais acerca do assunto. O ambiente de ensino deve favorecer o aprendizado profundo, por estar intimamente relacionado com uma aprendizagem significativa. Metodologias ativas de aprendizagem são vinculadas a maior qualidade de aprendizado, por propiciarem ambiente favorável ao aprendizado profundo. Objetivo: Este estudo teve como objetivos avaliar a qualidade do aprendizado de estudantes de Medicina de um curso que adota metodologias ativas de aprendizagem e correlacioná-la com as percepções dos alunos acerca do ambiente educacional e com dados sociodemográficos. Método: Trata-se de estudo descritivo transversal realizado com estudantes do curso de Medicina da Universidade Federal de São Carlos (UFSCar), do primeiro ao sexto ano. Foram utilizados os instrumentos R-SPQ-2F, DREEM e questionário sociodemográfico. Realizou-se análise descritiva, e compararam-se as frequências por meio do teste do qui-quadrado ou teste exato de Fisher. As diferenças entre médias foram avaliadas por meio de teste t de Student ou teste de Mann-Whitney, quando se compararam somente dois grupos, ou por meio de análise de variância (ANOVA) ou teste de Kruskal-Wallis, quando comparados mais de dois grupos. As associações entre as variáveis quantitativas foram verificadas por meio do coeficiente de correlação de Pearson ou de Spearman. A análise estatística foi realizada com auxílio do programa IBM SPSS Statistics versão 25.0, e adotou-se como parâmetro de significância um valor de p < 0,05. Resultado: Entrevistaram-se 226 alunos. A pontuação média para abordagem profunda foi de 33,52 e, para a abordagem superficial, 17,42. Em relação à percepção do ambiente educacional, a média foi de 129,77 pontos. As variáveis objetivas que demonstraram influência sobre o aprendizado foram: sexo, idade de início do curso, contato prévio com metodologias ativas, prática de idiomas, ter graduação ou pós-graduação prévia, receber auxílio financeiro de familiares e ano da graduação. Conclusão: As metodologias ativas de aprendizagem podem estimular a adoção de estratégias de aprendizado profundo. O estudo dos fatores que influenciam na abordagem de aprendizado é complexo e envolve questões individuais subjetivas.

Abstract: Introduction: The quality of learning of medical students has been a recurring subject of research in recent decades, but there are scarce national studies on it. The learning environment should encourage deep learning, as it is intimately related to meaningful learning. Active learning methods are linked to better quality of learning, since they provide a favorable environment for deep learning. Objective: The aim of this study was to evaluate the quality of learning of students at a medical school that adopts active learning methods for all course years and correlate it to students’ views on educational environment and sociodemographic data. Method: This is a cross-sectional descriptive study with 1st to 6th-year medical students from the Federal University of São Carlos. The R-SPQ-2f, DREEM and sociodemographic questionnaires were applied. Descriptive analysis was performed, and frequencies were compared using chi-square test or Fisher’s exact test. Differences between means were evaluated with either Student’s t-test or Mann-Whitney’s test, when comparing only two groups, and with one-way analysis of variance (ANOVA) or Kruskal-Wallis’ test, when comparing more than two groups. Associations between quantitative variables were verified with either Pearson’s or Spearman’s correlation coefficient. Statistical analysis was performed with IBM SPSS Statistics version 25.0. For significance, p-value<0.05 was adopted. Result: 226 students were interviewed. The average deep learning score was 33.52 points, and, for superficial learning, 17.42 points. As for how the environment was perceived, the average score was 129.77. The objective variables that showed influence in learning were sex, course start age, previous contact with active learning methods, language study, previous undergraduate training, or post-graduate degree, receiving financial help from family and current course year. Conclusion: Active learning methods may stimulate the adoption of deep learning strategies. The evaluation of factors that influence study approaches is complex, involving subjective individual parameters.

https://doi.org/10.1590/1981-5271v45.3-20200551 122 downloads

11.

Retinal ischemia following mandible tumor treatment with steroid injection
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Lando, Leonardo

; Silva, Hugo Mendes

; Cardoso, Lincoln Lara

; Isaac, David Leonardo Cruvinel

; Teixeira, Kim-Ir-Sen Santos

; Avila, Marcos

Arquivos Brasileiros de Oftalmologia

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dec 2020, Volume 83 N. 6 Pages 543 - 546

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O granuloma central de células gigantes é um tumor ósseo raro que afeta pacientes jovens com comprometimento anatômico e funcional da maxila e mandíbula. A terapia com injeção de esteroides constitui uma modalidade de tratamento menos invasiva para o controle da doença em casos selecionados. A isquemia retiniana é uma complicação relatada em vários procedimentos médicos, incluindo intervenções odontológicas, e pode levar à perda da visão com mau prognóstico. Relatamos um caso de doença isquêmica arteriolar da retina após o tratamento com granuloma central de células gigantes com corticosteroides injetados locais.

ABSTRACT Central giant cell granuloma is a rare osseous tumor affecting young patients with anatomical and functional compromise of the maxilla and mandible. Steroid injection therapy constitutes a less invasive treatment modality for disease control in selected cases. Retinal ischemia is a reported complication of multiple medical procedures, including dental interventions, and may lead to loss of vision with poor prognosis. We report a case of retinal arteriolar ischemic disease following central giant cell granuloma management with local injected corticosteroids.

https://doi.org/10.5935/0004-2749.20200099 322 downloads

12.

Advisor gender and advice justification in advice taking
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Ribeiro, Vinicius Farias

; Hilal, Adriana Victoria Garibaldi de

; Avila, Marcos Gonçalves

RAUSP Management Journal

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mar 2020, Volume 55 N. 1 Pages 4 - 21

Abstract: En | Text: En | PDF: En

Abstract Purpose The purpose of this paper is to identify under what circumstances advisor gender and advice justification influence advice taking by managers. Design/methodology/approach The authors designed a quasirational managerial decision experiment with both analytic and intuitive cues. The design was a 2 × 2 between-subjects factorial, in which gender (male/female) and advice justification (intuitive/analytic) were crossed. The experiment involved two independent samples, taken from Amazon Mechanical Turk workers and Brazilian professionals. Findings Results suggest that, in general, analytic justification is more valued than intuitive justification. The findings also infer that depending on the advisees’ sample and providing that advice justification is analytic, quasirational scenarios seem to favor male advisors (MTurk sample) or both male and female advisors with “male values” (professional sample), as analysis is traditionally considered a “male value.” Practical implications Analytic justification will likely lead to more advice utilization in quasirational managerial situations, as it may act as a safeguard for the accuracy of the offered advice. Social implications The results might signal an ongoing, but slow, process leading to the mitigation of gender stereotypes, considering that the male gender stereotype was active in the MTurk sample, but not in the professional one. Originality/value This study contributes to the advice-taking research field by showing the interplay between advisor gender and advice justification in a quasirational managerial decision setting with both analytic and intuitive cues. In advice-taking literature, observations are usually collected from students. However, as this study focused on managerial decisions, the authors collected independent samples from MTurk workers and Brazilian professionals.

https://doi.org/10.1108/rausp-08-2018-0068 331 downloads

13.

Evaluation of Toxocara canis Glycosylated TES Produced in Pichia pastoris for Immunodiagnosis of Human Toxocariasis
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Santos, Lucas Moreira dos

; Cerqueira, Michele Pepe

; Gaboardi, Giana Carla

; Magalhães, Carolina Georg

; Donassolo, Rafael Amaral

; Rodrigues, Rafael Rodrigues

; Griep, Emili

; Ferreira, Marcos Roberto

; Elefant, Guita Rubinsky

; Avila, Luciana Farias da Costa

; Scaini, Carlos James

; Moreira, Ângela Nunes

; Conceição, Fabricio Rochedo

Brazilian Archives of Biology and Technology

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2020, Volume 63 elocation e20190148

Abstract: En | Text: En | PDF: En

Abstract Recombinant proteins are a suggested alternative for the diagnosis of toxocariasis. The current Escherichia coli recombinant protein overexpression system usually produces insoluble products. As an alternative, yeast such as Pichia pastoris have secretory mechanisms, which could diminish the cost and time for production. This study aimed to produce recombinant proteins in Pichia pastoris and verify their sensibility and specificity in an indirect ELISA assay. Two sequences (rTES-30 and rTES-120) of Toxocara canis excretory-secretory antigens were cloned in a pPICZαB vector and expressed in P. pastoris KM71H. Sera samples collected from human adults infected by Toxocara spp. were tested by indirect ELISA using rTES-30 and rTES-120 as antigens. Recombinant proteins were detected at 72 hours after induction, in the supernatant, as pure bands between 60~70 kDa with hyperglycosylation. Regarding diagnosis potential, recombinant antigens had high specificity (95.6%); however, sensitivity was 55.6% for rTES-30 and 68.9% for rTES-120. Further deglycosylation of the P. pastoris antigens did not seem to affect ELISA performance (p>0.05). The low sensitivity in the serodiagnosis diminished any advantage that P. pastoris expression could have. Therefore, we do not recommend P. pastoris recombinant TES production as an alternative for the diagnosis of toxocariasis.

https://doi.org/10.1590/1678-4324-2020190148 516 downloads

14.

Características clínico-epidemiológicas de los pacientes de la cohorte Lupus Paraguay (2013-2014)
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Vázquez, Marcos Aurelio

; Rojas, Elías

; Losanto, Jonathan

; Bauman, Karin

; Acosta, María Eugenia

; Avila, Gabriela

; Melo, Marcia

; Duarte, María Margarita

; Acosta-Colman, Isabel

Memorias del Instituto de Investigaciones en Ciencias de la Salud

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apr 2019, Volume 17 N. 1 Pages 69 - 74

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology that presents severe clinical manifestations and unpredictable course. It has been observed in several cohorts that this disease has a more aggressive behavior in the non-Caucasian population due to socioeconomic, demographic and genetic differences. The objective of this study was to describe the clinical-epidemiological characteristics of SLE patients included in the LUPUS-PY cohort and the current situation of the samples stored in the BIOBANCO IMID-PY. The study was based on the review of clinical histories and clinical-epidemiological questionnaires on the day of inclusion in the LUPUS-PY registry. Frequencies were calculated for the categorical variables and the means with their standard deviation for the continuous ones. A total of 83 patients with a diagnosis of SLE were included consecutively (mean age: 34.4 ± 10.0 years), 86.7% were female, 55% were from Asunción, 49.1% had basic education level, 45% received monthly a minimum salary (approximately 350 US dollars) or less. Forty six point eight percent did not perform any type of physical activity. The mean time elapsed since the onset of symptoms and the diagnosis of SLE was 9.3 ± 13.7 years, and the time of evolution of the disease until entry into the registry was 5.9 ± 6.3. Sixteen percent reported a family history of autoimmune diseases. The first manifestation of the disease more described was articular. Patients with SLE in our center have both clinical and epidemiological characteristics similar to those reported by other cohorts.

RESUMEN El lupus eritematoso sistémico (LES) es una enfermedad autoinmune, de etiología desconocida que presenta manifestaciones clínicas de gravedad y curso impredecible. Se ha observado en varias cohortes que esta enfermedad tiene un comportamiento más agresivo en la población no caucásica debido a diferencias socioeconómicas, demográficas y genéticas. El objetivo del estudio es describir las características clínico-epidemiológicas de los pacientes con LES incluidos en la cohorte LUPUS-PY y la situación actual de las muestras custodiadas en el BIOBANCO IMID-PY. Estudio basado en la revisión de historias clínicas y en los cuestionarios clínico-epidemiológicos del día de la inclusión al registro LUPUS-PY. Se calcularon las frecuencias para las variables categóricas y las medias con su desvío estándar para las continuas. Se incluyeron de forma consecutiva, 83 pacientes con diagnóstico de LES (edad media: 34,4±10,0 años), el 86,7% era del sexo femenino, el 55% provenía de Asunción, el 49,1% tenía nivel educativo básico, el 45% percibía un ingreso mensual de un sueldo mínimo (aproximadamente 350 dólares americanos) o menos. El 46,8% no realizaba ningún tipo de actividad física. La media del tiempo trascurrido desde el inicio de los síntomas y el diagnóstico del LES fue de 9,3±13,7 años y el tiempo de evolución de la enfermedad hasta el ingreso al registro fue de 5,9±6,3. El 16% refirió antecedentes familiares de enfermedades autoinmunes. La primera manifestación de la enfermedad más descripta fue la articular (45%). Los pacientes con LES de nuestro centro tienen características tanto clínicas como epidemiológicas similares a las reportadas por otras cohortes.

https://doi.org/10.18004/mem.iics/1812-9528/2019.017(01)69-074 643 downloads

15.

O programa de Hölderlin para Iena: Ideias estéticas além de Kant e Schiller
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Quevedo, Wagner de Avila

Pandaemonium Germanicum

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apr 2019, Volume 22 N. 36 Pages 273 - 292

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A concepção filosófica de Hölderlin compõe-se de duas percepções fundamentais: a indivisibilidade do racional e do sensível presente na ideia platônica de beleza, e a compreensão, de fundo espinosista, de que a unidade assim pensada apreende-se como diferenciada em si mesma. O presente artigo aborda a primeira percepção. Em fins de 1794, Hölderlin abandona o preceptorado na casa dos von Kalb e muda-se para Iena, onde trabalha em seu Hipérion e assiste às preleções de Fichte. No entanto ele não chega na cidade de mãos vazias. Numa carta a Christian Neuffer, de outubro de 1794, Hölderlin manifesta a intenção de escrever um ensaio sobre as ideias estéticas de Kant, que deveria servir como comentário do Fedro, de Platão, ao mesmo tempo que avançaria, mais do que Schiller teria ousado, para além do limite kantiano através de uma simplificação de sua estética. Como o texto jamais foi escrito, o presente trabalho apresenta os elementos articulados na carta e procura reconstituir os marcos gerais do ensaio planejado.

Abstract Hölderlin’s philosophical conception structures itself upon two insights: the indivisibility between sensibility and reason, such as potentially thought in the Platonic idea of beauty, and the Spinozistic inspired view of a unity differentiated in itself. The aim of this article is to address the former. Towards the end of 1794, Hölderlin left his job as a preceptor, at von Kalb’s, and moves to Jena, where he works on his Hyperion and attends to Fichte’s lectures. Nevertheless, he does not come to town empty-handed: before arriving, Hölderlin writes to Christian Neuffer and expresses the wish to draw up an essay on Kant’s aesthetic ideas, which would both comment upon Plato’s Phaedrus and take a step far beyond Kant by means of a simplification of his theory of beauty. In this matter, Hölderlin considered that Schiller had failed to trespass on the Kantian boundary, but states that he should have dared to. Once the essay has never been written, I will present the elements wherein the writing was conceived, and thus restore its general guidelines.

https://doi.org/10.11606/1982-88372236273 755 downloads

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