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[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Publication date: 2024-04-08

Abstract: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Does Postpartum Hypopituitarism Influence the Craniofacial Pattern? A Case-Control Study with Sheehan’s Syndrome Patients
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Cavalcante, Davi de Sá

; Quidute, Ana Rosa Pinto

; Martins, Manoel Ricardo Alves

; Carvalho, Francisco Samuel Rodrigues

; Cid, Adília Mirela Pereira

; Silva, Paulo Goberlanio de Barros

; Aguiar, Andrea Silvia Walter de

; Ribeiro, Thyciana Rodrigues

; Costa, Fábio Wildson Gurgel

International journal of odontostomatology

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mar 2023, Volume 17 N. 1 Pages 38 - 45

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN: Este estudio tuvo como objetivo evaluar los aspectos morfológicos craneofaciales de los pacientes con síndrome de Sheehan (SHS). Se realizó un estudio observacional con 19 mujeres diagnosticadas con SHS y 19 controles asociados por edad y sexo. Se obtuvieron radiografías cefalométricas laterales y se analizaron 30 medidas lineales y angulares mediante el software Radiocef Studio 2. La edad media de los pacientes fue de 65,47 ± 10,19 años. Los principales hallazgos fueron proposición maxilar (52,63 %) y mandíbula (52,63 %) con respecto a la base del cráneo, prognatismo mandibular en 73,68 %, patrón de crecimiento profundo en 42,1 %, aumento del plano mandibular en 36,84 % y reducción de la altura facial anterior. El grupo SHS mostró diferencias estadísticamente significativas en SNB (p=0,026), N-Me (p=0,006), longitud del paladar blando (p=0,011) y Ena-Me (p<0,001) en comparación con los controles. El análisis de la puntuación de la desviación estándar reveló valores alterados en relación con las longitudes maxilares y mandibulares totales. El SHS mostró una morfología craneofacial alterada, caracterizada por prognatismo maxilomandibular, tipo braquifacial, aumento del plano mandibular y reducción de la longitud del velo del paladar. Este estudio informa hallazgos novedosos en SHS.

ABSTRACT: This study aimed to assess the craniofacial morphologic aspects of Sheehan’s syndrome (SHS) patients.An observational study was performed with 19 women diagnosed with SHS and 19 controls matched by age and sex. Lateral cephalometric radiographs were obtained, and 30 linear and angular measurements were analyzed using the Radiocef Studio 2 software. The mean age of patients was 65.47 ± 10.19 years. The main findings were propositioned maxilla (52.63 %) and mandible (52.63 %) relative to the cranial base, mandibular prognathism in 73.68 %, deep growth pattern in 42.1 %, increased mandibular plane in 36.84 %, and reduction in anterior facial height. The SHS group showed statistically significant differences in SNB (p=0.026), N-Me (p=0.006), soft palate length (p=0.011), and Ena-Me (p<0.001) in comparison with controls. The standard deviation score analysis revealed altered values in relation to total maxillary and mandibular lengths. SHS showed altered craniofacial morphology, characterized by maxillo- mandibular prognathism, brachyfacial type, increased mandibular plane, and reduction in soft palate length. This study reports novel findings in SHS.

Posicionamento sobre Doença Isquêmica do Coração – A Mulher no Centro do Cuidado – 2023
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Oliveira, Gláucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Rassi, Daniela do Carmo

; Bragança, Érika Olivier Vilela

; Moura, Lidia Zytynski

; Arrais, Magaly

; Campos, Milena dos Santos Barros

; Lemke, Viviana Guzzo

; Avila, Walkiria Samuel

; Lucena, Alexandre Jorge Gomes de

; Almeida, André Luiz Cerqueira de

; Brandão, Andréa Araujo

; Ferreira, Andrea Dumsch de Aragon

; Biolo, Andreia

; Macedo, Ariane Vieira Scarlatelli

; Falcão, Breno de Alencar Araripe

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Marques-Santos, Celi

; Freire, Claudia Maria Vilas

; Pellegrini, Denise

; Alexandre, Elizabeth Regina Giunco

; Braga, Fabiana Goulart Marcondes

; Oliveira, Fabiana Michelle Feitosa de

; Cintra, Fatima Dumas

; Costa, Isabela Bispo Santos da Silva

; Silva, José Sérgio Nascimento

; Carreira, Lara Terra F.

; Magalhães, Lucelia Batista Neves Cunha

; Matos, Luciana Diniz Nagem Janot de

; Assad, Marcelo Heitor Vieira

; Barbosa, Marcia M.

; Silva, Marconi Gomes da

; Rivera, Maria Alayde Mendonça

; Izar, Maria Cristina de Oliveira

; Costa, Maria Elizabeth Navegantes Caetano

; Paiva, Maria Sanali Moura de Oliveira

; Castro, Marildes Luiza de

; Uellendahl, Marly

; Oliveira Junior, Mucio Tavares de

; Souza, Olga Ferreira de

; Costa, Ricardo Alves da

; Coutinho, Ricardo Quental

; Silva, Sheyla Cristina Tonheiro Ferro da

; Martins, Sílvia Marinho

; Brandão, Simone Cristina Soares

; Buglia, Susimeire

; Barbosa, Tatiana Maia Jorge de Ulhôa

; Nascimento, Thais Aguiar do

; Vieira, Thais

; Campagnucci, Valquíria Pelisser

; Chagas, Antonio Carlos Palandri

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 7 elocation e20230303

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230303

Effects of Calendula officinalis extract on liver histopathology, lipid profile, and oxidative stress in rats submitted to a diet rich in cholesterol and carbohydrates
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Fontes, Gleide Gatti

; Freitas, Rodrigo de Barros

; Almeida, Palloma Porto

; Lima, Luciana Moreira

; Cardoso, Silvia Almeida

; Pizziolo, Virginia Ramos

; Tabach, Ricardo

; Wanderley, Almir Gonçalves

; Arida, Ricardo Mario

; Caricati-Neto, Afonso

; Taha, Murched Omar

; Carvalho, Camilo Amaro de

; Tallo, Fernando Sabia

; Menezes-Rodrigues, Francisco Sandro

Acta Cirúrgica Brasileira

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2023, Volume 38 elocation e383723

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To evaluate the modulatory properties of Calendula officinalis L. (Asteraceae) (C. officinalis) extract on cafeteria diet-fed rats. Methods: A cafeteria diet was administered ad libitum for 45 days to induce dyslipidemia. Then, the rats were treated with the formulations containing C. officinalis in the doses of 50, 100, and 150 mg/kg or only with the vehicle formulation; the control group received a commercial ration. Results: The cafeteria diet decreased glutathione S-transferase activity and high-density lipoprotein plasmatic levels and damaged the hepatic architecture. The C. officinalis extract was able to reduce lipid infiltration in liver tissue and to modulate oxidative stress and lipid profile markers. Conclusions: The correlations between the variables suggest a pathological connection between oxidative stress markers and serum lipid profile.

https://doi.org/10.1590/acb383723

Clinicopathologic analysis of oral dermoid and epidermoid cysts: a Brazilian multicenter study
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CUNHA, John Lennon Silva

; ANDRADE, Allany de Oliveira

; CAVALCANTE, Israel Leal

; BARROS, Caio César da Silva

; SOUSA NETO, Sebastião Silvério de

; BARROS, Joyce Magalhães de

; LEITE, Larissa Sandy da Silva

; FÉLIX, Fernanda Aragão

; TURATTI, Eveline

; CARVALHO, Francisco Samuel Rodrigues

; SOUSA, Sílvia Ferreira de

; MENDONÇA, Elismauro Francisco de

; ANBINDER, Ana Lia

; PIRES, Fábio Ramoa

; ALVES, Pollianna Muniz

; NONAKA, Cassiano Francisco Weege

; ANDRADE, Bruno Augusto Benevenuto de

Brazilian Oral Research

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2023, Volume 37 elocation e107

Abstract: En | Text: En | PDF: En

Abstract Dermoid cysts (DCs) and epidermoid cysts (ECs) are uncommon developmental cysts affecting the oral cavity. This study aims to evaluate patients with oral DCs and ECs and their demographic and clinicopathologic features. A retrospective descriptive cross-sectional study was performed. A total of 105,077 biopsy records of oral and maxillofacial lesions from seven Brazilian oral pathology centers were analyzed. All cases diagnosed as oral DCs and ECs were reviewed, and clinical, demographic, and histopathological data were collected. The series comprised 32 DCs (31.4%) and 70 ECs (68.6%). Most of the DCs occurred on the floor of the mouth (n = 14; 45.2%) of women (n = 17; 53.1%) with a mean age of 34.6 ± 21.6 years. All DCs were lined partially or entirely by stratified squamous epithelium (100%). Chronic inflammatory cells, melanin pigmentation, multinucleated giant cell reaction, and cholesterol clefts were observed in the fibrous capsule . Most of the ECs affected the labial mucosa (n = 20; 31.7%) of men (n = 39; 56.5%) with a mean age of 48.0±19.8 years. Microscopically, most ECs (n = 68; 97.1%) were lined entirely by stratified squamous epithelium. Two cysts (2.9%) showed areas of respiratory metaplasia. Chronic inflammatory cells, melanin pigmentation, multinucleated giant cell reaction, and cholesterol clefts were also observed in the fibrous capsule. Conservative surgical excision was the treatment of choice in all cases. Oral DCs and ECs are uncommon and often clinically misdiagnosed lesions. Clinicians should consider DCs and ECs in the differential diagnosis of soft tissue lesions in the oral cavity, mainly located on the floor of the mouth and labial mucosa.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0107

FROM PARÁ TO MANAOS EM TRADUÇÃO: UMA ANÁLISE DOS MOVIMENTOS TRADUTÓRIOS E DO MAGNETISMO INTERLINGUAGENS E INTERGÊNEROS
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Barros, Silvia Helena Benchimol

; Silva, Tabita Fernandes da

Cadernos de Tradução

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2023, Volume 43 N. spe2 Pages 230 - 259

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The corpus of this study is the text From Pará to Manaos, chapter V of the book A Journey in Brazil, by Elizabeth Agassiz, published in 1868 by Ticknor and Fields and translated from English to Portuguese in 2023, by Silvia Benchimol to compose the publication Traduzindo a Amazônia III. In addition to the centripetal property, which makes the writings about this work converge to its textual, social, ideological, narrative, linguistic and aesthetic elements, we emphasize its centrifugal power that provokes, from the center – the text – movements in different directions. The language meanders through different discursive genres in an orchestrated way – travel diary, report, letters, footnotes – accompanied by the translation. In the meticulous descriptions that reveal the writer’s enchantment for the mystery and exuberance of the forest, the language is strongly marked by literary and poetic aesthetics, fostering images with photographic precision that transport us to those places. No less evident are the scientific references that spill over the text, a rich and specialized glossary. The translation receives the source text and re-conceives it in another language in the same locus of the events, providing the translator with a dip in memories and facts, reconstructing personal experiences in the act of rewriting.

Resumo O corpus deste estudo é o texto From Pará to Manaos, capítulo V da obra A Journey in Brazil, de autoria de Elizabeth Agassiz, publicado em 1868 pela editora Ticknor and Fields e traduzido da língua inglesa para a língua portuguesa em 2023 por Silvia Benchimol para compor a publicação Traduzindo a Amazônia III1 propriedade centrípeta, que faz os escritos a respeito dessa obra convergirem para seus elementos textuais, sociais, ideológicos, narrativos, linguísticos e estéticos, ressalta-se o poder centrífugo da obra que provoca, a partir do centro – o texto – um afastamento em diferentes direções. A linguagem serpenteia por diversos gêneros discursivos de modo orquestrado – diário de viagem, relato, cartas, notas de rodapé – movimento acompanhado pela tradução. Nas descrições minuciosas que revelam o encantamento da escritora pelo mistério e exuberância da floresta, a linguagem é fortemente marcada pela estética literária e poética, propiciando construções de imagens de precisão fotográfica que nos transmovem para aqueles lugares. Não menos evidentes são as referências científicas que derramam sobre o texto rico glossário especializado. A tradução recebe o texto fonte e o reconcebe em outro código linguístico no locus dos acontecimentos, propiciando à tradutora um mergulho em memórias e fatos, reconstruindo experiências pessoais no ato da reescrita.

https://doi.org/10.5007/2175-7968.2023.e96106

Fundação SESP em Alagoas (1960-1990): o saber e fazer das parteiras e curiosas à luz de Collière
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Crispim Costa, Laís de Miranda

; Melo Coêlho Barros, Larissa

; Santos, Silvia Alves dos

; Santos, Regina Maria dos

; das Neves Guimarães, Marcela

; de Oliveira e Silva, Jovânia Marques

Historia y MEMORIA

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dec 2022, N. 25 Pages 309 - 342

Resumen Estudio histórico-social que describe el trabajo de reclutamiento, formación y supervisión de parteras y mujeres curiosas desarrollado por la Fundación Servicio Especial de Salud Pública (FSESP) en Alagoas en el período de 1960 a 1990 y analiza el saber y la práctica de estas parteras y mujeres curiosas. Se utilizaron fuentes documentales y orales, producidas en entrevistas realizadas a partir de la historia oral temática, otorgado por dos visitadores de salud, seis parteras, tres mujeres curiosas, un médico y una enfermera. Los resultados mostraron que parteras y mujeres curiosas fueron reclutadas y capacitadas por los visitadores de salud. Cuando pudieron ayudar en el parto, recibieron una bolsa con materiales y fueron acompañados por visitadores de salud o enfermeras para limpiar la bolsa y renovar las instrucciones. Se analizó la actuación de parteras/ mujeres curiosas a partir del referencial teórico de Marie Françoise Collière, revelando que brindaron cuidados basados en conocimientos y prácticas adquiridas a través de la experiencia, buscando asegurar la continuidad de la vida. Se concluyó que la FSESP era un importante servicio de salud en Alagoas por sus actividades de educación en salud, revisión, cuidado y atención a parturientas y recién nacidos, y también evidenció prácticas que han sido mejoradas a lo largo de los años.

Résumé Cette étude historique-sociale décrit le travail de recrutement, formation et contrôle de sages-femmes curieuses développée par la Fondation Service Spécial de Santé Publique (FSESP) en Algoas entre 1960 et 1990. On analyse aussi le savoir et la pratique de ces sages-femmes, en consultant des sources documentaires et orales, ainsi que des entretiens faites à deux agents de santé, six sages-femmes, trois femmes curieuses, un médecin et une infirmière. Les résultats ont montré les sages-femmes et les femmes curieuses ont été recrutées et formées par les agents de santé. Lorsqu'elles ont pu aider dans les accouchements, elles ont reçu des instruments pour participer de cet événement. Finalement, on a analysé le rôle des sages-femmes à partir des théories de Marie Françoise Collière, lesquelles théories ont permis de montrer que ces femmes ont mis en place des connaissances basées sur l'expérience afin de garantir la continuité de la vie. On conclut que la FSESP était un important service de santé en Alagoas de par ses activités d'éducation en santé, soins et attention aux parturientes et nouveaux nés, des pratiques améliorés au fil des années.

Abstract Carried out by the Fundación Servicio Especial en Salud Pública (FSESP) in Algoas between 1960 and 1990, this is a socio-historical study that describes the work of recruiting, training and supervising midwives and curious women. Both written and oral sources were used, produced in interviews from oral thematic history. The participants were two health visitors, six midwives, three curious women, a doctor, and a nurse. The results showed that the midwives and curious women were recruited and trained by the health visitors. When they could assist a birth, they received a bag with materials and were accompanied by the health visitors or nurses to clean the bags and renew the instructions. The actions of the midwives /curious women were analyzed from the referential theory of Marie Françoise Collière, which revealed that they provided care to patients based on knowledge and practices acquired through experience, seeking to secure the continuity of life. It was concluded that the FSESP was an important health service in Alagoas due to its activities in health education, revision, care and treatment of women in labor and newborns. Additionally, practices that have been improved throughout the years were found.

Resumo Estudo histórico-social que descreve o trabalho de recrutamento, treinamento e supervisão das parteiras e curiosas desenvolvido pela Fundação Serviço de Saúde Pública (FSESP) em Alagoas no recorte temporal de 1960 a 1990 e analisa o saber e o fazer destas parteiras e curiosas. Foram utilizadas fontes documentais e orais, estas produzidas em entrevistas realizadas com recurso da história oral temática, concedidas por duas visitadoras sanitárias, seis parteiras, três curiosas, um médico e uma enfermeira. Os resultados evidenciaram que as parteiras e curiosas eram recrutadas por visitadoras sanitárias para serem treinadas. Quando estavam aptas para partejar, recebiam uma bolsa com materiais e eram supervisionadas pelas visitadoras ou enfermeiras a fim de realizar a limpeza da bolsa e renovar as instruções. A atuação das parteiras/curiosas fora analisada com base no referencial teórico de Marie Françoise Collière, revelando que as mesmas prestavam cuidados a partir de saberes e fazeres adquiridos pela experiência buscando assegurar a continuidade da vida. Concluiu-se que a FSESP foi um importante serviço de saúde em Alagoas tendo em vista suas atividades de educação em saúde, reciclagem, atenção e cuidado às parturientes e recém-nascidos, além de revelar práticas que foram sendo aperfeiçoadas ao longo dos anos.

https://doi.org/10.19053/20275137.n25.2022.11669

ST-Elevation in a Patient with Acute Chagas Disease
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Pinto, Guilherme Dantas Campos

; Pimentel, José Henrique Martins

; Barros, Maria das Neves Dantas da Silveira

; Medeiros, Carolina de Araújo

; Carrazzone, Cristina de Fátima Velloso

; Matins, Silvia Marinho

; Oliveira Júnior, Wilson Alves de

International Journal of Cardiovascular Sciences

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jun 2022, Volume 35 N. 3 Pages 419 - 422

Abstract: En | Text: En | PDF: En

https://doi.org/10.36660/ijcs.20200396

Interaction between the impact of the Coronavirus disease 2019 pandemic and demographic characteristics on sexual/erectile dysfunction in Latin America: cross-sectional study
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Pérez, Constanza Alvear

; Michelutti, Luciana de Barros Cavalcanti

; Palharini, Maria Volpato

; Teixeira, Luisa Pasqualotto

; Silva, Valeria Regina

; Teixeira, Lucas Emmanuel Pedro de Paiva

; Silva, Silvia Lanziotti Azevedo da

; Botelho, Simone

International braz j urol

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jun 2022, Volume 48 N. 3 Pages 512 - 547

Abstract: En | Text: En | PDF: En

ABSTRACT Aim: Our objective was to investigate whether there is an interaction between the COVID-19 pandemic, demographic characteristics and erectile/sexual (E/S) function in individuals from Latin America. Materials and Methods: Cross-sectional study which included Latin American individuals over 18 years old, recruited through social media and interviewed between July and August 2020 by online surveys (Google Forms) in Portuguese and Spanish languages. The E/S function was evaluated through the following questionnaires: Simplified International Index of Erectile Function (IIEF-5) and Female Sexual Function Index (FSFI); while post-traumatic stress disorder (PTSD) triggered by the COVID-19 pandemic was assessed through the Impact of Event Scale Revised (IES-R). The data was analyzed by T Student, bivariate and multivariate logistic regression, with significance determined by the Wald test (p<0.05), using the R software v4.0. Results: Out of the 2016 individuals that responded to the survey, 1986 were included and 743 of them presented E/S dysfunction. PTSD occurrence was greater among people with E/S dysfunction when compared to those without E/S dysfunction, in the total score (males: IES-R=26.54[±19.17] and females: IES-R=35.92[±19.25]) and also in the three domains. It was found that those who do not live with a partner were 74% more likely to have E/S dysfunction, but living with a partner during the pandemic had a greater impact on E/S function. Conclusion: A negative interaction between the impact of the COVID-19 pandemic and erectile/sexual function of the Latin American population was observed, with greater implications among the individuals who live with their partners.

https://doi.org/10.1590/s1677-5538.ibju.2021.0764

10.

Mapping the morbidity and mortality of Chagas disease in an endemic area in Brazil
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Medeiros, Carolina de Araújo

; Silva, Maria Beatriz de Araújo

; Oliveira, André Luiz Sá de

; Alves, Sílvia Marinho Martins

; Barros, Maria das Neves Dantas da Silveira

; Cavalcanti, Maria da Glória Aureliano de Melo

; Oliveira, Gênova Maria de Azevedo

; Carrazzone, Cristina de Fátima Velloso

; Oliveira Jr, Wilson Alves de

; Medeiros, Zulma Maria de

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e5

Abstract: En | Text: En | PDF: En

ABSTRACT Chagas disease is among the 21 neglected diseases according to the World Health Organization. This study aimed to investigate the morbidity and mortality distribution of Chagas disease for identifying areas with greater prevalences and deaths of the disease in Northeast Brazil. A population-based ecological study was performed from 2016 to 2018 using data on acute Chagas disease patients from the Disease Notification Information System, chronic cases from the Chagas Disease and the referral Heart Failure Outpatient Clinic in Pernambuco, and Chagas disease-related mortality from the Mortality Information System. The unit of analysis were Pernambuco State mesoregions. The indicators were spatialized into thematic maps on the occurrence and mortality of the disease per 100,000 inhabitants. No cases of acute disease were reported in the period analyzed. Data on 801 chronic Chagas disease patients were analyzed. The population showed an average age of 62 years, with female predominance. The most prevalent comorbidity was systemic arterial hypertension and cardiologic involvement without ventricular dysfunction. The average chronic disease occurrence rate was 3.2/ 100,000 people/ year. As for deaths in the mortality system; in total, 350 deaths were recorded, showing male predominance, age ≥ 60 years, and chronic disease with cardiac involvement as the main mortality cause. The annual average mortality proportion was 1.6/100,000 people. The chronic case distribution showed spatial heterogeneity, with the highest rates of chronic disease and deaths observed in two mesoregions, with the main cause of death being heart-related. This highlights the need for more specialized services in areas with higher burden of the disease to avoid delay in the patients’ care.

https://doi.org/10.1590/s1678-9946202264005

11.

Prevalence of ankyloglossia and factors that impact on exclusive breastfeeding in neonates
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Vilarinho, Sílvia

; Dantas-Neta, Neusa Barros

; Duarte, Danilo Antônio

; Imparato, José Carlos Pettorossi

Revista CEFAC

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2022, Volume 24 N. 1 elocation e5121

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: determinar a prevalência de anquiloglossia em recém-nascidos e verificar os fatores que interferem na amamentação exclusiva e geram dificuldades na amamentação. Métodos: trata-se de um estudo observacional longitudinal, realizado em maternidade pública do município de Teresina, PI, Brasil. A amostra foi composta por 397 pares (mães e bebês). Para o diagnóstico de anquiloglossia foi realizada a parte I do Protocolo de Avaliação do Frênulo da Língua com Escores para Bebês. Após seis meses do nascimento, as mães foram entrevistadas e responderam questões sobre indicação e realização de frenotomia e tempo de aleitamento materno. Foram realizados análise descritiva dos dados, teste Qui-quadrado e Regressão de Poisson bivariada e multivariada (p<0,05). Resultados: a prevalência de anquiloglossia foi de 4,3% (n=17). A taxa de retorno para segundo momento da pesquisa foi de 70,8% (n=281). Das crianças examinadas, 14 foram indicadas para frenotomia lingual, mas apenas uma foi submetida ao procedimento. Crianças com anquiloglossia tiveram tempo de amamentação exclusiva igual ao de crianças com frênulo da língua normal (valor de p=0,876). Anquiloglossia não apresentou associação com dificuldade de amamentação (RP=1,0 IC95%0,8-1,1, valor de p=0,441) ou constituiu fator para não amamentação exclusiva por 6 meses (RP=1,1 IC95%0,9-1,2, valor de p=0,390). Conclusões: a prevalência da anquiloglossia na população estudada foi de 4,3% e o uso de mamadeira no primeiro mês de vida e dificuldades de amamentação foram considerados como fatores impeditivos para amamentação exclusiva.

ABSTRACT Objective: to determine the prevalence of ankyloglossia in neonates and verify factors that interfere with exclusive breastfeeding and cause difficulties in breastfeeding. Methods: an observational longitudinal study conducted at a public maternity hospital in Teresina, Piauí, Brazil. The sample comprised 397 mother-child pairs. Ankyloglossia was diagnosed with the part I of the Baby Lingual Frenulum Assessment Protocol with Scores. Six months after the children were born, the mothers were interviewed and answered questions on the indication and performance of frenotomy and time of breastfeeding. Descriptive analysis of the data, chi-square test and bivariate and multivariate Poisson regression were conducted (p < 0.05). Results: the prevalence of ankyloglossia was 4.3% (n = 17). The attendance rate for the second moment of the research was 70.8% (n = 281). Of the examined children, 14 were indicated for lingual frenotomy, but only one was submitted to the procedure. The time of exclusive breastfeeding of children with ankyloglossia was equal to that of children with a normal lingual frenulum (p-value = 0.876). Ankyloglossia was not associated with breastfeeding difficulties (PR = 1.0 95%CI 0.8-1.1, p-value = 0.441), neither was it a factor for not breastfeeding exclusively for 6 months (PR = 1.1 95%CI 0.9-1.2, p-value = 0.390). Conclusions: the prevalence of ankyloglossia in the studied population was 4.3%. Baby bottle use in the first month of life and breastfeeding difficulties were hindering factors for exclusive breastfeeding.

https://doi.org/10.1590/1982-0216/20222415121

12.

Use of dentifrices and mouthwashes during orthodontic treatment in the clinical management of orthodontists
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BARROS, Paulo André Gomes

; DE LIMA, Cláudia Batista Vieira

; CUSTODIO, William

; VENEZIAN, Giovana Cherubini

; VEDOVELLO, Silvia Amélia Scudeler

; GÓES, Vívian Fernandes Furletti de

RGO - Revista Gaúcha de Odontologia

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2022, Volume 70 elocation e20220020

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar o conhecimento dos profissionais da ortodontia quanto à prescrição de dentifrícios e antissépticos durante o tratamento ortodôntico. Métodos: Foi realizado um estudo observacional e descritivo exploratório de abrangência nacional com 440 ortodontistas brasileiros, baseado em cálculo amostral prévio, para avaliação da prática clínica dos ortodontistas na prescrição de dentifrícios e antissépticos. Questionários eletrônicos auto administrados foram enviados aos profissionais da Ortodontia. Os dados foram analisados por meio de tabelas de distribuição de frequência absolutas e relativas. Resultados: Verificou-se que o antisséptico bucal mais indicado (39,8%) foi o Colgate Periogard® (Colgate®) e 421 dos participantes (95,7%) conhecem o seu ingrediente ativo (digluconato de clorexidina). Além do antisséptico Colgate Periogard®, os participantes também foram questionados sobre qual o ingrediente ativo presente nos seguintes antissépticos, cujas respostas assertivas estavam na seguinte ordem %, Cepacol® (Sanofi-Aventis®) com 60,7%, Colgate Plax® (Colgate®) com 54,5% e Listerine® (Jhonson&Jhonson®) com 51,6%. Quanto ao regime terapêutico da clorexidina 63,9% indicaram assertivamente sua utilização sendo a mesma de 2 vezes ao dia durante 7 a 10 dias. O dentifrício mais indicado foi o Colgate Total 12®, sendo que 60,18% desses indivíduos indicaram corretamente seu composto ativo. Conclusão: De acordo com a metodologia empregada, pôde-se concluir que os profissionais da ortodontia conhecem e prescrevem métodos de controle químico aos pacientes durante o tratamento ortodôntico e a maioria identifica os compostos químicos ativos presentes nas fórmulas de antissépticos e dentifrícios.

ABSTRACT Objective: To evaluate the knowledge of orthodontic professionals regarding the prescription of dentifrices and antiseptics during orthodontic treatment. Methods: An observational and descriptive exploratory study of national scope was conducted with 440 Brazilian orthodontists, based on previous sample calculations, to evaluate the clinical practice of orthodontists in prescribing dentifrices and antiseptics. Self-managed electronic questionnaires were sent to orthodontic professionals. The data were analyzed by means of absolute and relative frequency distribution tables. Results: It was verified that the most indicated mouthwash (39.8%) was Colgate Periogard® and 421 of the participants (95.7%) know its active ingredient (chlorhexidine digluconate). Besides Colgate Periogard® antiseptic, the participants were also questioned about which active ingredient present on the following antiseptics, whose assertive answers were in the following order of %, Cepacol® (Sanofi-Aventis®) with 60.7%, Colgate Plax® (Colgate®) with 54.5% and Listerine® (Jhonson&Jhonson®) with 51.6%. As for the chlorhexidine therapeutic regime, 63.9% have stated assertively its use, being this one of 2 times a day during 7 to 10 days. The most indicated tooth was Colgate Total 12®, and 60.18% of these individuals correctly indicated its active compound. Conclusion: According to the methodology employed, it could be concluded that orthodontic professionals know and prescribe methods of chemical control to patients during orthodontic treatment and most identify the active chemical compounds present in antiseptic and tooth formulas.

https://doi.org/10.1590/1981-86372022002020200081

13.

Phenolic compounds, carotenoids, and antioxidant activity in a super-sweet corn hybrid
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Cruz, Larissa Leandro da

; Gonçalves, Gabriel Moreno Bernardo

; Glória, Lorena de Lima

; Pereira, Silvia Menezes de Faria

; Carlos, Lanamar de Almeida

; Vivas, Marcelo

; Pereira, Messias Gonzaga

; Oliveira, Daniela Barros de

Pesquisa Agropecuária Brasileira

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2022, Volume 57 elocation e02663

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste trabalho foi determinar os carotenoides totais, os fenólicos totais e a atividade antioxidante de 'UENF SD 08' (milho superdoce) e compará-los com os de 'UENF50611' (milho comum). O conteúdo de carotenoides totais foi determinado de acordo com Rodriguez-Amaya, o de fenólicos totais pelo método de Folin-Ciocalteau e a atividade antioxidante pelo método de sequestro de radicais livres de 2,2-difenil-1-picrilhidrazila (DPPH). Para 'UENF SD 08', os valores médios foram: 936,76±16,34 µg 100 g−1 para carotenoides, 346,0±3,80 mg 100 g−1 para fenólicos e 45,53±0,01% para atividade antioxidante. Para 'UENF50611', os valores médios foram: 1.173,38±21,66 µg 100 g−1 para carotenoides, 563,33±7,97 mg 100 g−1 para fenólicos e 59,82±0,11 para atividade antioxidante. O milho 'UENF50611' apresentou maior atividade antioxidante devido aos seus maiores teores de carotenoides e compostos fenólicos; porém, os valores observados para o milho superdoce 'UENF SD 08' estão dentro das faixas já descritas na literatura. 'UENF SD 08' contém menor concentração de carotenoides e compostos fenólicos que 'UENF50611', seu background genético não mutante. Contudo, o milho superdoce apresenta vantagens agronômicas, é considerado fonte dos metabólitos secundários avaliados e seu consumo pode contribuir para dieta com teor mais elevado de antioxidantes.

Abstract The objective of this work was to determine the total carotenoids, total phenolics, and antioxidant activity of 'UENF SD 08' (super-sweet corn) and to compare them with those of 'UENF50611' (field corn). The total carotenoid content was determined according to Rodriguez-Amaya, the total phenolic content by the Folin-Ciocalteau method, and the antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging method. For 'UENF SD 08', the average values were: 936.76±16.34 µg 100 g−1 for carotenoids, 346.0±3.80 mg 100 g−1 for phenolics, and 45.53±0.01% for antioxidant activity. For UENF50611, the average values were: 1,173.38±21.66 µg 100 g−1 for carotenoids, 563.33±7.97 mg 100 g−1 for phenolics, and 59.82±0.11% for antioxidant activity. UENF50611 showed a higher antioxidant activity observed due to its higher levels of carotenoids and phenolic compounds; however, the values observed for the 'UENF SD 08' super-sweet corn are within the ranges already described in the literature. 'UENF SD 08' contains a lower concentration of carotenoids and phenolic compounds than 'UENF50611', its nonmutant genetic background. However, the super-sweet corn 'UENF SD 08' has agronomic advantages, is considered a source of the evaluated secondary metabolites, and its consumption can contribute to a diet with a higher content of antioxidants.

https://doi.org/10.1590/s1678-3921.pab2022.v57.02663

14.

Associação Positiva entre Autoanticorpos contra LDL Oxidada e HDL-C: Um Novo Mecanismo para Cardioproteção de HDL?
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Nunez, Carla Evelyn Coimbra

; Oliveira, Joaquim Barreto

; Barros-Mazon, Silvia de

; Zago, Vanessa H. S.

; Kaplan, Denise Beheregaray

; Nakamura, Ruy T.

; Gidlund, Magnus Ake

; Gomes, Erica I. L.

; Cazita, Patricia Miralda

; Nakandakare, Edna

; Carmo, Helison R.

; Sposito, Andrei C.

; Faria, Eliana Cotta de

Arquivos Brasileiros de Cardiologia

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2022, N. ahead

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento No microambiente da placa aterosclerótica, os fosfolipídios oxidados expressos na superfície de lipoproteína de baixa densidade oxidada (oxLDL) se ligam a receptores scavenger em macrófagos provocando a formação de células espumosas e a progressão da placa. Autoanticorpos contra oxLDL (oxLDL-Ab) interagem com epítopos oxidativos levando à formação de imunocomplexos que são incapazes de interagir com receptores de macrófagos, assim suprimindo a aterogênese. A liberação de oxLDL-Ab pelas células B envolve a resposta da interleucina 5 e Th2, que por sua vez são potencializadas pela HDL. Assim, levantamos a hipótese de que indivíduos com níveis mais altos de HDL-C podem apresentar níveis elevados de oxLDL-Ab. Objetivo Avaliar a relação entre os níveis de HDL-C e oxLDL-Ab. Métodos Indivíduos assintomáticos (n = 193) foram agrupados de acordo com sua concentração de HDL-C para uma das três categorias seguintes: baixa (< 68 mg/dL), intermediária (de 68 a 80 mg/dL) ou alta (> 80 mg/dL). Os valores p < 0,05 foram considerados estatisticamente significativos. Resultados Nossa análise incluiu 193 indivíduos (média etária: 47 anos; masculino: 26,3%). Em comparação com os indivíduos no menor tercil de HDL-C, os mais elevados foram mais velhos (36 versus 53 anos; p = 0,001) e, menos frequentemente, masculinos (42,6% versus 20,9%; p = 0,001). Os valores médios de oxLDL-Ab aumentaram à medida que o grupo HDL-C aumentou (0,31, 0,33 e 0,43 unidades, respectivamente; p = 0,001 para tendência). A regressão linear simples encontrou uma relação significativa e positiva entre a variável independente, HDL-C, e a variável dependente, oxLDL-Ab (R = 0,293; p = 0,009). Essa relação manteve-se significativa (R = 0,30; p = 0,044), após ajuste por covariáveis. Os níveis de apolipoproteína AI também estiveram relacionados a oxLDL-Ab nos modelos de regressão linear simples e ajustada. Conclusões HDL-C e oxLDL-Ab estão independentemente relacionados.

Abstract Background In the atherosclerotic plaque microenvironment, oxidized phospholipids expressed in the oxidized low-density lipoprotein (oxLDL) surface bind to scavenger receptors of macrophages eliciting foam cell formation and plaque progression. Auto-antibodies against oxLDL (oxLDL-Ab) interact with oxidative epitopes leading to the formation of immune complexes that are unable to interact with macrophage receptors, thus abrogating atherogenesis. Release of oxLDL-Ab by B cells involves interleukin 5 and Th2 response, which in turn are potentiated by HDL. Thereby, we hypothesized that individuals with higher levels of HDL-C may plausibly display elevated titers of oxLDL-Ab. Objective To evaluate the relationship between HDL-C and oxLDL-Ab levels. Methods Asymptomatic individuals (n = 193) were grouped according to their HDL-C concentration to one of three categories: low (< 68 mg/dL), intermediate (68 to 80 mg/dL) or high (> 80 mg/dL). P values < 0.05 were considered statistically significant. Results Our analysis included 193 individuals (mean age: 47 years; male: 26.3%). Compared to individuals in the lowest HDL-C tertile, those in the highest tertile were older (36 versus 53 years; p = 0.001) and less frequently male (42.6% versus 20.9%; p = 0.001). Mean values of oxLDL-Ab increased as the HDL-C group escalated (0.31, 0.33 and 0.43 units, respectively; p = 0.001 for trend). Simple linear regression found a significant, positive relationship between the independent variable, HDL-C, and the dependent variable, oxLDL-Ab (R = 0.293; p = 0.009). This relation remained significant (R = 0.30; p = 0.044), after adjustment by covariates. Apolipoprotein AI levels were also related to oxLDL-Ab in both simple and adjusted linear regression models. Conclusion HDL-C and oxLDL-Ab are independently related.

https://doi.org/10.36660/abc.20210796

15.

MRSA outbreak in a Neonatal Intensive Care Unit in a developed country: importance of rapid detection of reservoirs and implementation of intervention measures
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Moura, Maria Luísa

; Rizek, Camila Fonseca

; Aguiar, Elisa

; Barros, Ana Natiele da Silva

; Costa, Sibeli

; Santos, Sania Alves dos

; Marchi, Ana Paula

; Gibelli, Maria Augusta Bento Cicaroni

; Tragante, Carla Regina

; Araújo, Maria Rita Elmor de

; Rossi, Flavia

; Guimaraes, Thais

; Costa, Silvia Figueiredo

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e58

Abstract: En | Text: En | PDF: En

ABSTRACT We described a MRSA bloodstream infection outbreak that was rapidly identified and controlled in a Neonatal Intensive Care Unit after implementation of a bundle of measures, including PCR-screening and HCW decolonization. We found 35% of healthcare workers(HCW) colonized with S. aureus by PCR, one of them that presented skin lesion positive for MSSA (same clone and spa type than two patients). Our findings raise the hypothesis that the outbreak could be related to HCW colonization.

https://doi.org/10.1590/s1678-9946202264058

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