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au:COSTA, PAULO AFONSO DA

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Traços funcionais de espécies arbóreas de cerrado sensu stricto e sua importância para a manutenção de comunidades nativas
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Costa, João Paulo

; Dias Neto, Olavo Custódio

; Santos, Lilian Cristina da Silva

; Rodrigues, Amanda Wolberg

; Rios, Jovan Martins

; Prado Júnior, Jamir Afonso do

; Vale, Vagner Santiago do

Ciência Florestal

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dec 2022, Volume 32 N. 4 Pages 1807 - 1829

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Functional traits are morpho-physiological characteristics of species that can significantly influence ecological processes in their natural environment and can be used to form functional groups. Functional groups are species with similar characteristics and functions in communities. The initial objective of the study was to detect patterns in the functional traits of tree species in cerrado sensu stricto. We sought to answer: 1) is it possible to group species into functional groups using leaf and architecture traits, 2) which traits best explained the survival/maintenance of species in their communities. The foliar and architectural functional traits of 32 tree species from cerrado sensu stricto were evaluated. The analyses were able to form four distinct functional groups for cerrado sensu stricto. Group 1 showed trees with higher wood density, dry mass and leaf area and high volume and biomass values. Most species have leaves with low specific leaf area and high leaf area and dry mass. Group 2 had small species with low crown volume and biomass, however, it was the group with the highest specific leaf area and leaf water percentage. Group 3 was formed by species with the lowest contribution of biomass and crown volume in the study, and also showed low values for wood density, leaf area and dry mass, being typically small-sized species. Group 4 showed the highest values for crown volume, biomass and sorghum in the study, configuring the group of species with the largest size of the study, but showed low values for specific leaf area and percentage of water in the leaf.

Resumo Traços funcionais são características morfo-fisiológicas das espécies capazes de influenciar significativamente os processos ecológicos em seu ambiente natural e podem ser utilizadas para formar grupos funcionais. Grupos funcionais são espécies com semelhantes características e funções nas comunidades. O objetivo inicial do estudo foi detectar padrões quanto aos traços funcionais de espécies arbóreas de cerrado sensu stricto. Buscamos responder: 1) é possível agrupar as espécies em grupos funcionais utilizando traços foliares e de arquitetura, 2) quais traços melhor explicaram a sobrevivência/manutenção das espécies em suas comunidades. Foram avaliados os traços funcionais foliares e de arquitetura de 32 espécies arbóreas de cerrado sensu stricto. As análises foram capazes de formar quatro grupos funcionais distintos para cerrado sensu stricto. O grupo 1 apresentou árvores com maior densidade da madeira, massa seca e área foliar e altos valores de volume e biomassa. A maioria das espécies possuem folhas com baixa área foliar específica e alta área foliar e massa seca. O grupo 2 apresentou espécies de pequeno porte, com baixo volume de copa e biomassa, entretanto, foi o grupo com maior área foliar específica e percentual de água na folha. O grupo 3 foi formado por espécies com o menor aporte de biomassa e volume de copa do estudo, e também apresentou valores baixos para densidade de madeira, área foliar e massa seca, sendo espécies tipicamente de pequeno porte. O grupo 4 apresentou os maiores valores de volume de copa, biomassa e súber do estudo, configurando o grupo de espécies com o maior porte do estudo, porém, apresentou baixos valores de área foliar específica e percentual de água na folha.

https://doi.org/10.5902/1980509842472

Simulação da produção por sortimento de madeira em povoamentos de Tectona grandis L. na região norte do estado do Mato Grosso
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Oliveira, Pedro Paulo Gomes de

; Oliveira Filho, Paulo Costa de

; Guimarães, Fabiane Aparecida Retslaff

; Figueiredo Filho, Afonso

; Oliveira, Edilson Batista de

Ciência Florestal

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dec 2022, Volume 32 N. 4 Pages 2263 - 2287

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The present study was developed with the objective of providing equations to estimate the volume, assortments (tapering functions) and the construction of site curves, seeking to forecast the growth and production of a Teak stand located in the municipality of Alta Floresta, Northern region of the state of Mato Grosso, using a growth and forest production simulator called SisTeca. 154 permanent plots were used, whose remedies totaled 909 observations covering ages 2 to 14 years, in addition to the cubing of 139 trees by the Smalian method. The Schumacher-Hall model was adjusted to estimate individual volumes, the fifth-degree taper function to estimate assortments and the Schumacher model for the construction of site curves. At the end, projections were made with SisTeca using the original equations (default) and inserting into the SisTeca the volume, tapering and site equations developed in this research. The adjusted volume, tapering and site equations for Teak stands in the Alta Floresta region, state of Mato Grosso, showed good results of adjustment and precision and are important tools for Teca, either to estimate current stocks or to be inserted in systems growth and production like SisTeca. The EMBRAPA simulator for Teca, when equipped with the dendrometric tools developed in the research, generated better prognosis, compared to the observed values from the plots available for the species in the region of Alta Floresta, state of Mato Grosso. Thus, the need to acquire more representative data for the species is emphasized, both in terms of age and site to develop robust growth and production systems and / or more efficient dendrometric tools to calibrate the SisTeca.

Resumo O presente estudo foi desenvolvido com objetivo de disponibilizar equações para estimar o volume, sortimentos (funções de afilamento) e a construção de curvas de sítio, buscando realizar a prognose do crescimento e da produção de um povoamento de Teca localizado no município de Alta Floresta, região Norte do estado de Mato Grosso, utilizando um simulador de crescimento e produção florestal denominado SisTeca. Foram utilizadas 154 parcelas permanentes, cujas remedições totalizaram 909 observações, contemplando as idades 2 a 14 anos, além da cubagem de 139 árvores pelo método de Smalian. Foram ajustados o modelo de Schumacher-Hall para estimar os volumes individuais, a função de afilamento de quinto grau para estimar sortimentos e o modelo de Schumacher para a construção de curvas de sítio. Ao final foram realizadas projeções com o SisTeca usando as equações originais (default) e inserindo no SisTeca as equações de volume, afilamento e sítio desenvolvidas nesta pesquisa. As equações de volume, afilamento e sítio ajustadas para povoamentos de Teca na região de Alta Floresta, estado de Mato Grosso, apresentaram bons resultados de ajuste e precisão e são ferramentas importantes para o manejo da Teca, seja para estimar estoques correntes, seja para inserção em sistemas de crescimento e produção como o SisTeca. O simulador da EMBRAPA para a Teca quando munido com as equações dendrométricas desenvolvidas na pesquisa gerou melhores prognoses, comparativamente aos valores observados oriundos das parcelas disponíveis para a espécie na região de Alta Floresta, estado de Mato Grosso. Dessa forma, ressalta-se a necessidade de aquisição de dados mais representativos para a espécie, tanto em termos de idades como de sítio, no sentido de desenvolver sistemas de crescimento e produção robustos e/ou ferramentas dendrométricas mais eficientes visando calibrar o SisTeca.

https://doi.org/10.5902/1980509867978

Análise espacial da taxa de detecção de casos suspeitos de síndrome congênita pelo vírus Zika, Maranhão, 2015 a 2018
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Falcão Neto, Paulo Afonso de Oliveira

; Branco, Maria dos Remédios Freitas Carvalho

; Costa, Silmery da Silva Brito

; Câmara, Ana Patrícia Barros

; Marques, Thayná Millena Nunes França

; Araujo, Adriana Soraya

; Loureiro, Flávia Helen Furtado

; Dias Júnior, José de Jesus

; Silva, Maria do Socorro da

; Queiroz, Rejane Christine de Sousa

; Ribeiro, Marizélia Rodrigues Costa

; Kulkarni, Manisha Ann

; Silva, Antônio Augusto Moura da

; Santos, Alcione Miranda dos

Revista Brasileira de Epidemiologia

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2022, Volume 25 elocation e220002

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivo: Identificar padrões espaciais em casos de lactentes com alterações de crescimento e desenvolvimento relacionadas à infecção pelo vírus Zika e outras etiologias infecciosas (neste trabalho denominado de síndrome congênita pelo vírus Zika), notificados no Maranhão de 2015 a 2018 e sua relação com variáveis socioeconômicas e demográficas. Métodos: Estudo ecológico de casos suspeitos notificados de síndrome congênita pelo vírus Zika nos 217 municípios do Maranhão, Brasil. Calculou-se a autocorrelação espacial pelos índices de Moran local e global (I) univariado e bivariado da taxa de detecção de casos suspeitos de síndrome congênita pelo vírus Zika com índice de desenvolvimento humano municipal, densidade demográfica, índice de Gini e tempo de emancipação político-administrativa dos municípios. O índice de Moran local foi calculado para localizar clusters com autocorrelação espacial significativa. Resultados: Houve autocorrelação espacial na análise univariada da taxa municipal de detecção de casos suspeitos de síndrome congênita pelo vírus Zika (I=0,494; p=0,001) e, na análise bivariada, correlação positiva da taxa de detecção de casos suspeitos com índice de desenvolvimento humano municipal (I=0,252; p=0,001), densidade demográfica (I=0,338; p=0,001) e tempo de emancipação dos municípios (I=0,134; p=0,001). Não houve correlação significativa da taxa de detecção de casos suspeitos com o índice de Gini (I= -0,033; p=0,131). Cinco clusters de alta detecção de casos suspeitos foram encontrados em áreas distintas do estado. Conclusões: Os municípios com maior índice de desenvolvimento humano municipal, maior densidade demográfica e mais tempo de emancipação político-administrativa tiveram mais casos suspeitos notificados de síndrome congênita pelo vírus Zika.

ABSTRACT: Objective: To identify spatial patterns in cases of changes in growth and development related to Zika virus infection and other infectious etiologies (denominated Zika virus congenital syndrome in this study) reported in Maranhão from 2015 to 2018 and their relation with socioeconomic and demographic variables. Methods: Ecological study of notified Zika virus congenital syndrome cases in the 217 cities of Maranhão, Brasil. Spatial autocorrelation was calculated using GeoDa 1.14 software and the local and global (I) Moran’s index in univariate and bivariate analyses on Zika virus congenital syndrome incidence rate with Municipal Human Development Index (MHDI), population density, Gini coefficient and the cities’ time of administrative political emancipation. Local Moran’s Index was calculated to identify clusters with significant spatial autocorrelation. Results: Spatial autocorrelation was checked in univariate analysis of the incidence rate of Zika virus congenital syndrome (I=0,494; p=0,001) and positive correlation in bivariate analysis of the incidence rate with Municipal Human Development Index (I=0,252; p=0,001), population density (I=0,338; p=0,001) and the cities’ time of administrative political emancipation (I=0,134; p=0,001). The correlation between incidence rate with Gini coefficient was not significant (I= -0,033; p=0,131). Five high-incidence clusters were found in distinct areas of the state. Conclusions: Cities with higher MHDI, higher population density and more years of administrative political emancipation had more cases of Zika virus congenital syndrome notified.

https://doi.org/10.1590/1980-549720220002

Análise espacial da taxa de detecção de casos suspeitos de síndrome congênita pelo vírus Zika, Maranhão, 2015 a 2018
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Falcão Neto, Paulo Afonso de Oliveira

; Branco, Maria dos Remédios Freitas Carvalho

; Costa, Silmery da Silva Brito

; Câmara, Ana Patrícia Barros

; Marques, Thayná Millena Nunes França

; Araujo, Adriana Soraya

; Loureiro, Flávia Helen Furtado

; Dias Júnior, José de Jesus

; Silva, Maria do Socorro da

; Queiroz, Rejane Christine de Sousa

; Ribeiro, Marizélia Rodrigues Costa

; Kulkarni, Manisha Ann

; Silva, Antônio Augusto Moura da

; Santos, Alcione Miranda dos

Revista Brasileira de Epidemiologia

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2022, Volume 25 elocation e220002

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720220002

Effects of the use of synthetic astaxanthin in the feeding of Lophiosilurus alexandri, a neotropical siluriform fish
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COSTA, DANIEL P. DA

; SILVA, MÁRCIO JOSÉ S.

; GERALDI, RICARDO MARCELO

; LORENZINI, JOÃO PAULO

; MATTIOLI, CRISTIANO C.

; OLIVEIRA, AFONSO DE LIGUORI

; LUZ, RONALD K.

; MIRANDA-FILHO, KLEBER C.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Suppl. 4 elocation e20210434

Abstract: En | Text: En | PDF: En

Abstract Aiming to test the capacity of retention of carotenoids in tissues, Lophiosilurus alexandri juveniles were fed diets containing 0, 25, 50, 100, 200, and 400 mg/kg of synthetic astaxanthin for 62 days. The inclusion of astaxanthin did not result in significant differences in growth, weight gain, apparent feed conversion, and feed efficiency of the fish. Blood biochemistry and liver histology did not change with the different treatments. At the level of 100 mg/kg of inclusion, there were the highest levels of carotenoids in the blood, and muscle and the smallest difference between the muscle x integument ratio.

https://doi.org/10.1590/0001-3765202220210434

Optimization of red blood cell unit storage during SARS-COV-2 Pandemic: adopting new strategies to ensure supply in a decentralized blood bank in Brazil
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Costa, Cristiano Batista

; Cortez, Afonso José Pereira

; Adão, Daiane Daniela

; Almeida, Carolina Maganha de

; Taguchi, Ellen Mari

; Oliveira, Ingrid de

; Santos, Janaína Fernanda de Oliveira

; Rosa, Ana Paula Rodrigues da

; Tokunaga, Juliana Trapanotto da Silva

; Arnoni, Carine Prisco

; Latini, Flavia Roche Moreira

Hematology, Transfusion and Cell Therapy

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sep 2021, Volume 43 N. 3 Pages 229 - 235

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: As coronavirus disease-2019 (COVID-19) spread worldwide and social restrictions were intensified, difficulties in blood supply were expected to result in a shortage of blood donors, logistic issues and a change in blood consumption. Consequences could be detrimental to the meeting of the blood supply demand, especially in a decentralized blood bank in the State of São Paulo responsible for providing blood to more than 100 hospitals, mostly of the public health system. Aiming to minimize negative effects and focusing on maintenance of the blood supply, a different approach was discussed and adopted. Materials and methods: Briefly, strategies were related to monitoring and promoting measures to achieve a positive RBC unit balance. Thus, the number of donors, transfusions, RBC unit inventory, RBC unit loss and RBC units within up to 5 days from the expiration date were evaluated. Results: Several strategies were adopted to ensure sufficient availability of RBC units: blood donation was improved with social media and extra blood collections, a restrictive transfusion protocol was implemented, a new logistic process to use RBC units closer to the expiration date was established and non-isogroup transfusions were avoided. Conclusion: Altogether, described strategies were crucial to optimize blood storage during the pandemic. Investing in monitoring and logistics contributed to a positive RBC unit balance and conserving these strategies could be useful.

https://doi.org/10.1016/j.htct.2021.03.002 18 downloads

IS THERE CORRELATION BETWEEN HUMAN PAPILLOMAVIRUS (HPV) AND ESOPHAGEAL EPIDERMOID CARCINOMA?
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WOELLNER, Luiz Filipe Alkamin

; MEDEIROS, Juliano Smaniotto de

; RIBAS, Carmen Australia Paredes Marcondes

; NASSIF, Paulo Afonso Nunes

; RIBAS-FILHO, Jurandir Marcondes

; SOBRAL, Ana Cristina Lira

; ARIEDE, Bruno Luiz

; COSTA, Debora Azeredo Pacheco Dias DA

; MALAFAIA, Osvaldo

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2021, Volume 34 N. 1 elocation e1528

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Racional: Atualmente a infecção persistente pelo papilomavírus humano (HPV) tem sido relacionada em algumas regiões geográficas como fator de risco para o carcinoma epidermoide do esôfago. Ela resulta na imunoexpressão da proteína p16, que tem sido utilizada como marcadora da linhagem oncogênica por este agente etiológico. Objetivo: Correlacionar aspectos epidemiológicos do carcinoma epidermoide do esôfago com a prevalência de infecção pelo HPV. Métodos: Foram analisados 58 casos buscando-se perfil epidemiológico dos pacientes, com suas peças submetidas à análise histopatológica e imunoistoquímica pelo p16. Resultado: Dos 58 casos avaliados, 40 eram homens e 18 mulheres, com idade média de 63,2 anos. A imunoexpressão pelo p16 foi de 46,55%. Conclusão: A prevalência de infecção pelo HPV é alta no carcinoma epidermoide de esôfago apresentando-se em quase a metade dos casos (46,55%), sem diferenciação de idade quanto aos gêneros.

ABSTRACT Background: Currently, persistent human papillomavirus (HPV) infection has been related in some geographic regions as a risk factor for esophageal squamous cell carcinoma. It results in the immunoexpression of the p16 protein, which has been used as marker of the oncogenic lineage by this etiological agent. Aim: To correlate epidemiological aspects of esophageal squamous cell carcinoma with the prevalence of HPV infection. Methods: Fifty-eight cases were analyzed and submitted to histopathological and immunohistochemical analysis by p16. Results: Of the 58 cases evaluated, 40 were men and 18 women, with a mean age of 63.2 years. p16 immunoexpression was positive in 46.55%. Conclusion: The prevalence of HPV infection is high in esophageal squamous cell carcinoma presenting in almost half of the cases (46.55%), without gender differentiation.

https://doi.org/10.1590/0102-672020200002e1528 690 downloads

Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis
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Bonfiglioli, Karina Rossi

; Mota, Licia Maria Henrique da

; Ribeiro, Ana Cristina de Medeiros

; Kakehasi, Adriana Maria

; Laurindo, Ieda Maria Magalhães

; Giorgi, Rina Dalva Neubarth

; Duarte, Angela Luzia Branco Pinto

; Reis, Ana Paula Monteiro Gomides

; Souza, Mariana Peixoto Guimarães Ubirajara e Silva de

; Brenol, Claiton Viegas

; Pinheiro, Geraldo da Rocha Castelar

; Albuquerque, Cleandro Pires de

; Castro, Charlles Heldan de Moura

; Pinto, Gustavo Luiz Behrens

; Verztman, Jose Fernando

; Muniz, Luciana Feitosa

; Bertolo, Manoel Barros

; Pinto, Maria Raquel da Costa

; Louzada Júnior, Paulo

; Cruz, Vitor Alves

; Pereira, Ivanio Alves

; Freitas, Max Vitor Carioca de

; Cruz, Bóris Afonso

; Paiva, Eduardo

; Monticielo, Odirlei

; Provenza, José Roberto

; Xavier, Ricardo Machado

Advances in Rheumatology

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2021, Volume 61 elocation 70

Abstract: En | Text: En | PDF: En

Abstract Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality of life of the affected individual. The main objective of RA treatment is to achieve sustained clinical remission or low disease activity. However, up to 40% of patients do not respond to available treatments, including bDMARDs. New therapeutic targets for RA are emerging, such as Janus kinases (JAKs). These are essential for intracellular signaling (via JAK-STAT) in response to many cytokines involved in RA immunopathogenesis. JAK inhibitors (JAKi) have established themselves as a highly effective treatment, gaining increasing space in the therapeutic arsenal for the treatment of RA. The current recommendations aim to present a review of the main aspects related to the efficacy and safety of JAKis in RA patients, and to update the recommendations and treatment algorithm proposed by the Brazilian Society of Rheumatology in 2017.

https://doi.org/10.1186/s42358-021-00228-x

Accuracy of echocardiography and chest tomography for pulmonary hypertension screening in patients awaiting lung transplantation
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Degani-Costa, Luiza Helena

; Assis, João Paulo de

; Gonçalves, Pedro Paulo Pisaniello

; Gushken, Fernanda

; Szarf, Gilberto

; Afonso Junior, José Eduardo

einstein (São Paulo)

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2021, Volume 19 elocation eAO5710

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo Avaliar a acurácia de uma estratégia de rastreamento de hipertensão pulmonar baseada na combinação de dados de ecocardiograma com as medidas derivadas da tomografia computadorizada (diâmetro da artéria pulmonar e razão entre diâmetro da artéria pulmonar e diâmetro da aorta ascendente) em pacientes pneumopatas crônicos encaminhados para transplante pulmonar. Métodos Estudo observacional retrospectivo realizado com pacientes com enfisema e fibrose pulmonar avaliados para transplante entre 2012 e 2016. Definiu-se hipertensão pulmonar como pressão arterial pulmonar média ≥25mmHg, ou entre 21 a 24mmHg, com resistência vascular pulmonar >3 unidades Wood no cateterismo direito. As medidas tomográficas foram realizadas por dois radiologistas independentes. Resultados Foram incluídos 13 pacientes com enfisema e 19 com fibrose pulmonar, sendo 18 com hipertensão pulmonar. Houve alta concordância entre os radiologistas em relação às medidas tomográficas (coeficientes de correlação intraclasse para diâmetro da artéria pulmonar de 0,936 e diâmetro da artéria pulmonar/diâmetro da aorta ascendente de 0,940). As áreas abaixo da curva ROC de diâmetro da artéria pulmonar, diâmetro da artéria pulmonar/diâmetro da aorta ascendente, e pressão sistólica da artéria pulmonar como preditores de hipertensão pulmonar foram 0,540, 0,629 e 0,783, respectivamente. A sensibilidade, especificidade e valor preditivo negativo da pressão de sistólica de artéria pulmonar ≥40mmHg foram 67%, 79% e 65%, respectivamente. O critério combinado de diâmetro da artéria pulmonar/diâmetro da aorta ascendente >1 e/ou pressão sistólica da artéria pulmonar ≥40mmHg mostrou sensibilidade de 72%, especificidade de 79%, e valor preditivo negativo de 69%. Conclusão Os diâmetros da artéria pulmonar e da aorta ascendente foram altamente reprodutíveis. A associação entre diâmetro da artéria pulmonar e diâmetro da aorta ascendente >1 e/ou pressão sistólica da artéria pulmonar ≥40mmHg melhorou a sensibilidade e o valor preditivo negativo para rastreamento de hipertensão pulmonar. Essa estratégia requer validação prospectiva para se avaliarem segurança e custo-efetividade.

ABSTRACT Objective To examine the accuracy of a pulmonary hypertension screening strategy based on a combination of echocardiographic data and tomographic measurements (pulmonary artery diameter and pulmonary artery diameter to ascending aorta diameter ratio) in patients with chronic lung disease referred for lung transplantation. Methods A retrospective observational study with patients with pulmonary emphysema or fibrosis referred for transplantation between 2012 and 2016. Pulmonary hypertension was defined as mean pulmonary artery pressure ≥25mmHg, or between 21 and 24mmHg, with pulmonary vascular resistance >3 Wood units on right heart catheterization. Tomographic measurements were made by two independent radiologists. Results This sample comprised 13 patients with emphysema and 19 patients with pulmonary fibrosis. Of these, 18 had pulmonary hypertension. The level of agreement in tomographic measurements made by radiologists was high (intraclass correlation coefficients 0.936 and 0.940, for pulmonary artery diameter and pulmonary artery diameter to ascending aorta diameter ratio, respectively). Areas under the ROC curves constructed for pulmonary artery diameter, pulmonary artery diameter to ascending aorta diameter ratio, and pulmonary artery systolic pressure as predictors of pulmonary hypertension were 0.540, 0.629 and 0.783, respectively. The sensitivity, specificity and negative predictive value of pulmonary artery systolic pressure ≥40mmHg were 67%, 79% and 65%, respectively. The combined criterion (pulmonary artery diameter to ascending aorta diameter ratio >1 and/or pulmonary artery systolic pressure ≥40mmHg) achieved sensitivity of 72%, specificity of 79%, and a negative predictive value of 69%. Conclusion Measurements of pulmonary artery and ascending aorta diameter were highly reproducible. The association of pulmonary artery and aortic diameter >1 and/or pulmonary artery systolic pressure ≥40mmHg improved the sensitivity and the negative predictive value for pulmonary hypertension screening. This strategy demands prospective validation to assess safety and cost-effectiveness.

https://doi.org/10.31744/einstein_journal/2021ao5710

10.

RELATIVE AGE EFFECT IN BRAZILIAN HANDBALL SELECTIONS
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Costa, Julio Cesar

; Montes, Flávio Afonso

; Weber, Vinicius Muller Reis

; Borges, Paulo Henrique

; Ramos-Silva, Luiz Fernando

; Ronque, Enio Ricardo Vaz

Journal of Physical Education

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2021, Volume 32 elocation e3227

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo do presente estudo foi avaliar o efeito relativo da idade (ERI) nas seleções Brasileira de handebol que competiram nos campeonatos mundiais das categorias Sub-19, Sub-21 e Adulta. A amostra foi composta por 160 jogadores de handebol do sexo masculino, sendo 47 pertencentes a categoria Sub-19, 48 a Sub-21 e 65 a Adulta. A idade cronológica, massa corporal, estatura e posição de jogo de cada atleta foram obtidas no site oficial da Federação Internacional de Handebol. O nível de significância adotado foi de 5%. ERI foi observado em todas as três seguintes categorias Sub-19 (X2=21.511, P<0.01), Sub-21 (X2=15.894, P=0.01) e adulta (X2=35.123, P<0.01). Além disso, não foi encontrado ERI no processo de re-seleção pela categoria sequencial (P= 0.63, Sub-19 para Sub-21; P=0.46, Sub-21 para Adulta). O ERI foi encontrado nas seleções brasileiras de handebol. Contudo, este efeito não foi encontrado no processo de re-seleção, assim, os jogadores sofrem grande influência do ERI na categoria Sub-19 e isto permanece durante as categorias subsequentes até a equipe adulta.

ABSTRACT The aim of this study was to evaluate the relative age effect (RAE) in Brazilian male handball teams who competed in the world championships in the U-19, U-21, and adult categories. The sample was composed by 160 male handball players, 47 players being on U-19 category, 48 on U-21, and 65 on Adult category. The chronological age, body mass, height, and game position of each athlete were obtained on the International Federation of Handball website. The adopted significance level was of 5%. RAE was observed in all the three following categories U-19 (X2=21.511, P<0.01), U-21 (X2=15.894, P=0.01) and Adults (X2=35.123, P<0.01). Moreover, no RAE was found in re-selection process by sequential category (P= 0.63, U-19 to U-21; P= 0.46, U-21 to Adult). The RAE is found in Brazilian male handball national teams. However, this effect was not found in re-selection process, thus, players have great influence of RAE in U-19 and this remains through subsequent categories.

https://doi.org/10.4025/jphyseduc.v32i1.3227

11.

Prevalence of virological and serological markers of SARS-CoV-2 infection in the population of Ribeirão Preto, Southeast Brazil: an epidemiological survey
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Martinez, Edson Zangiacomi

; Passos, Afonso Dinis Costa

; Fabbro, Amaury Lelis Dal

; Silva, Anderson Soares da

; Escarso, Andreia Cássia

; Pazin-Filho, Antônio

; Fonseca, Benedito Antônio Lopes da

; Maciel, Benedito Carlos

; Araújo, Daniel Cardoso de Almeida e

; Clé, Diego Villa

; Gaspar, Gilberto Gambero

; Santos, Jair Lício Ferreira dos

; Ferreira, Janise Braga Barros

; Souza, João Paulo

; Mello, Luane Marques de

; Santos, Luciane Loures dos

; Passos, Luzia Márcia Romanholi

; Siconelli, Márcio Junio Lima

; Cavalli, Ricardo de Carvalho

; Santana, Rodrigo de Carvalho

; Calado, Rodrigo do Tocantins

; Scarpelini, Sandro

; Bollela, Valdes Roberto

; Floriano, Vitor Gonçalves

; Bellissimo-Rodrigues, Fernando

Revista da Sociedade Brasileira de Medicina Tropical

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2021, Volume 54 elocation e0210-2021

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: This epidemiological household survey aimed to estimate the prevalence of the current and past SARS-CoV-2 infections in Ribeirão Preto, a municipality of southeast Brazil. METHODS: The survey was conducted in two phases using a clustered sampling scheme. The first phase spanned May 1-3 and involved 709 participants. The second phase spanned June 11-14, 2020, and involved 646 participants. RESULTS: During the first phase, RT-PCR performed on nasopharyngeal swabs was positive at 0.14%. The serological tests were positive in 1.27% of the patients during the first phase and 2.79% during the second phase. People living in households with more than five members had a prevalence of 10.83% (95%CI: 1.58-74.27) higher than those living alone or with someone other. Considering the proportion of the positive serological test results with sex and age adjustments, approximately 2.37% (95%CI: 1.32-3.42) of the population had been cumulatively infected by mid-June 2020, which is equivalent to 16,670 people (95%CI: 9,267-24,074). Considering that 68 deaths from the disease in the residents of the city had been confirmed as at the date of the second phase of the survey, the infection fatality rate was estimated to be 0.41% (95%CI: 0.28-0.73). Our results suggest that approximately 88% of the cases of SARS-CoV-2 infection at the time of the survey were not reported to the local epidemiological surveillance service. CONCLUSIONS: The findings of this study provide in-depth knowledge of the COVID-19 pandemic in Brazil and are helpful for the preventive and decision-making policies of public managers.

https://doi.org/10.1590/0037-8682-0210-2021 117 downloads

12.

Um Modelo Conceitual de Probabilidade para Determinação da Vulnerabilidade Populacional ao Clima
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Silva, Bruce Kelly da Nobrega

; Lucio, Paulo Sergio

; Silva, Fabrício Daniel dos Santos

; Silva, Madson Tavares

; Costa, Rafaela Lisboa

; Serrão, Edivaldo Afonso de Oliveira

; Silva, Vicente de Paulo Rodrigues da

; Rocha Júnior, Rodrigo Lins da

Revista Brasileira de Meteorologia

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dec 2020, Volume 35 N. spe Pages 881 - 889

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A avaliação da vulnerabilidade da população é uma análise dos impactos esperados, modelagem de risco, exposição, sensibilidade e falta de capacidade de adaptação de uma região ou de um setor específico aos efeitos de eventos climáticos extremos. A vulnerabilidade engloba uma variedade de conceitos incluindo sensibilidade ou suscetibilidade a danos e falta de capacidade para lidar e adaptar. Uma forma de analisar estes aspectos tão diferenciados é através de um processo estocástico, como a probabilidade condicional. Neste artigo, apresenta-se um modelo conceitual para avaliar a vulnerabilidade da população ao clima, levando em conta uma das regiões susceptíveis brasileiras, a Nordeste. Os resultados mostram que o indicador proposto IVPopS apresenta a região central semiárida mais vulnerável, além de uma avaliação detalhada em cada componente do indicador. áreas produtivas como Petrolina-PE estão com índices elevados de risco (0,604), exposição (0.863), sensibilidade (0,910), enquanto a incapacidade de adaptação está com índices baixos (0,002).

Abstract The population's vulnerability assessment is an analysis of the expected impacts, risk modeling, exposure, sensitivity and lack of adaptability of a specific region or sector to the effects of extreme weather events. The vulnerability encompasses a variety of concepts including sensitivity or susceptibility to harm and a lack of ability to cope and adapt. One way to analyze these very different aspects is through a stochastic process, such as conditional probability. In this article, a conceptual model is presented to assess the population's vulnerability to the climate, taking into account one of the susceptible regions of Brazil, the Northeast. The results show that the proposed indicator IVPopS presents the most vulnerable central semi-arid region, in addition to a detailed assessment in each component of the indicator. Production areas such as Petrolina-PE have high levels of risk (0,604), exposure (0,863), sensitivity (0,910), while the inability to adapt is low (0.002).

https://doi.org/10.1590/0102-77863550015 208 downloads

13.

Comparação de análises fitossociológicas e multivariadas na determinação do grau de conservação de áreas nativas de Cerrado
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Rios, Jovan Martins

; Mariano, Gabriel Venâncio Pereira

; Silva, Vanuza Pereira Garcia da

; Santos, Lilian Cristina da Silva

; Costa, João Paulo

; Zica, Lucas Ribeiro da Silva

; Santos, Bianca Garcia dos

; Santos, Ana Flávia Costa

; Prado Júnior, Jamir Afonso do

; Vale, Vagner Santiago do

Ciência Florestal

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sep 2020, Volume 30 N. 3 Pages 779 - 795

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A forte pressão antrópica no Cerrado torna necessários estudos para averiguar o nível de conservação de áreas que estão sujeitas a essa atividade. Com isso, objetivo do trabalho foi comparar e avaliar a florística, a estrutura e o grau de conservação de duas áreas adjacentes de Cerrado, sendo uma área de cerrado conservado (CC) e outra de cerrado antropizado (CA). Foram utilizados os parâmetros fitossociológicos convencionais: densidade relativa (DR), dominância relativa (DoR), frequência relativa (FR) e o valor de importância (VI), além dos índices de diversidade de Shannon-Wiener e equitabilidade de Pielou. Foram feitas análises de ordenação pelo método DCA, dendrograma de classificação (UPGMA) a partir dos índices de Sørensen-Dice e Bray-Curtis, além da divisão hierárquica dicotômica por Twinspan. O teste t de Student foi utilizado para comparar as variáveis, classes diamétricas e classes de altura. O cerrado conservado apresentou valores maiores para número de indivíduos, classes diamétricas, área basal e altura. O índice de diversidade por parcelas, número de espécies, indivíduos e área basal total foram diferentes estatisticamente em relação as duas áreas. Através das análises multivariadas foi possível segregar as parcelas com base no grau de conservação, tanto na análise de ordenação (DCA) quanto de classificação (Dendrograma). Os métodos utilizados foram eficientes para demonstrar as diferenças entre as duas áreas, porém a análise multivariada se mostrou eficiente em fornecer maior detalhamento na diferenciação.

Abstract The strong anthropic pressure in the Cerrado makes studies necessary to ascertain the level of conservation of areas that are subject to this activity. Thus, the objective of the work was to compare and evaluate the floristics, the structure and the degree of conservation of two adjacent areas of Cerrado, one area of conserved savanna (CC) and another of anthropized savanna (CA). Conventional phytosociological parameters were used: relative density (DR), relative dominance (DoR), relative frequency (FR) and the importance value (VI), in addition to the Shannon-Wiener diversity index and Pielou's equitability. Sorting analyzes were performed using the DCA method, classification dendrogram (UPGMA) based on the Sørensen-Dice and Bray-Curtis indices, in addition to the dichotomous hierarchical division by Twinspan. Student's t-test was used to compare variables, diametric classes and height classes. The conserved savannah presented higher values for the number of individuals, diametric classes, basal area and height. The diversity index by plots, number of species, individuals and total basal area were statistically different for the two areas. Through multivariate analyzes it was possible to segregate the plots based on the degree of conservation, both in the ordering analysis (DCA) and in the classification (Dendrogram). The methods used were efficient to demonstrate the differences between the two areas, however the multivariate analysis proved to be efficient in providing greater detail in the differentiation.

https://doi.org/10.5902/1980509835229 439 downloads

14.

Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)
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da Silva, Felipe Moura A

; da Silva, Katia Pacheco A

; de Oliveira, Luiz Paulo M

; Costa, Emmanoel V

; Koolen, Hector HF

; Pinheiro, Maria Lúcia B

; de Souza, Antonia Queiroz L

; de Souza, Afonso Duarte L

Memórias do Instituto Oswaldo Cruz

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2020, Volume 115 elocation e200207

Abstract: En | Text: En | PDF: En

BACKGROUND Since the World Health Organization (WHO) declared Coronavirus disease 2019 (COVID-19) to be a pandemic infection, important severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural proteins (nsp) have been analysed as promising targets in virtual screening approaches. Among these proteins, 3-chymotrypsin-like cysteine protease (3CLpro), also named main protease, and the RNA-dependent RNA polymerase (RdRp), have been identified as fundamental targets due to its importance in the viral replication stages. OBJECTIVES To investigate, in silico, two of the most abundant flavonoid glycosides from Dysphania ambrosioides; a medicinal plant found in many regions of the world, along with some of the putative derivatives of these flavonoid glycosides in the human organism as potential inhibitors of the SARS-CoV-2 3CLpro and RdRp. METHODS Using a molecular docking approach, the interactions and the binding affinity with SARS-CoV-2 3CLpro and RdRp were predicted for quercetin-3-O-rutinoside (rutin), kaempferol-3-O-rutinoside (nicotiflorin) and some of their glucuronide and sulfate derivatives. FINDINGS Docking analysis, based on the crystal structure of 3CLpro and RdRp, indicated rutin, nicotiflorin, and their glucuronide and sulfate derivatives as potential inhibitors for both proteins. Also, the importance of the hydrogen bond and π-based interactions was evidenced for the presumed active sites. MAIN CONCLUSIONS Overall, these results suggest that both flavonoid glycosides and their putative human metabolites can play a key role as inhibitors of the SARS-CoV-2 3CLpro and RdRp. Obviously, further researches, mainly in vitro and in vivo experiments, are necessary to certify the docking results reported here, as well as the adequate application of these substances. Furthermore, it is necessary to investigate the risks of D. ambrosioides as a phytomedicine for use against COVID-19.

https://doi.org/10.1590/0074-02760200207 2439 downloads

15.

Increased platelet distribution width and reduced IL-2 and IL-12 are associated with thrombocytopenia in Plasmodium vivax malaria
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Costa, Allyson Guimarães

; Chaves, Yury Oliveira

; Teixeira-Carvalho, Andréa

; Ramasawmy, Rajendranath

; Antonelli, Lis Ribeiro Valle

; Barbosa, Lucas

; Balieiro, Antonio

; Monteiro, Wuelton Marcelo

; Mourão, Maria Paula

; Lacerda, Marcus Vinicius Guimarães

; Martins-Filho, Olindo Assis

; Costa, Fabio Trindade Maranhão

; Malheiro, Adriana

; Nogueira, Paulo Afonso

Memórias do Instituto Oswaldo Cruz

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2020, Volume 115 elocation e200080

Abstract: En | Text: En | PDF: En

BACKGROUND Thrombocytopenia in malaria involves platelet destruction and consumption; however, the cellular response underlying this phenomenon has still not been elucidated. OBJECTIVE To find associations between platelet indices and unbalanced Th1/Th2/Th17 cytokines as a response to thrombocytopenia in Plasmodium vivax infected (Pv-MAL) patients. METHODS Platelet counts and quantification of Th1/Th2/Th17 cytokine levels were compared in 77 patients with uncomplicated P. vivax malaria and 37 healthy donors from the same area (endemic control group - ENCG). FINDINGS Thrombocytopenia was the main manifestation in 55 patients, but was not associated with parasitaemia. The Pv-MAL patients showed increases in the mean platelet volume (MPV), which may be consistent with larger or megaplatelets. Contrary to the findings regarding the endemic control group, MPV and platelet distribution width (PDW) did not show an inverse correlation, due the increase in the heterogeneity of platelet width. In addition, the Pv-MAL patients presented increased IL-1β and reduced IL-12p70 and IL-2 serum concentrations. Furthermore, the reduction of these cytokines was associated with PDW values. MAIN CONCLUSIONS Our data demonstrate that an increase in MPV and the association between reductions of IL-2 and IL-12 and PDW values may be an immune response to thrombocytopenia in uncomplicated P. vivax malaria.

https://doi.org/10.1590/0074-02760200080 790 downloads

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