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Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.

Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19.

https://doi.org/10.36660/abc.20220151

Clinical features of oral lichen planus and oral lichenoid lesions: an oral pathologist’s perspective
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Netto, Juliana de Noronha Santos

; Pires, Fábio Ramoa

; Costa, Karen Hurtado Andrade

; Fischer, Ricardo Guimarães

Brazilian Dental Journal

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sep 2022, Volume 33 N. 3 Pages 67 - 73

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Os achados clinico-patológicos que caracterizam de forma precisa o líquen plano oral (LPO) e as lesões liquenoides orais (LLO) ainda representam um desafio. O objetivo do presente estudo foi analisar, pela perspectiva do patologista oral, os achados clínicos do LPO e das LLO. Espécimes preenchendo os critérios histológicos para o diagnóstico de LPO e LLO, e também aqueles compatíveis com LPO (LPO-C), foram selecionados e as informações clínicas foram obtidas a partir das requisições laboratoriais. A amostra final foi composta de 221 casos, incluindo 119 LPO (53.8%), 65 LPO-C (29.4%) e 37 LLO (16.7%). As mulheres foram mais acometidas nos três grupos, mas o número de homens acometidos foi maior nas LLO. A média de idade foi menor no LPO (52.3 anos) em comparação com as LLO (57.9 anos) (p=0.020). O envolvimento da mucosa jugal e da língua foi mais frequente no LPO; o envolvimento gingival foi incomum nas LLO. O padrão reticular foi mais frequentemente encontrado no LPO, enquanto a associação dos padrões reticular e atrófico/erosivo/ulcerado foi mais comum no LPO-C e nas LLO (p=0.025). Em conclusão, o gênero e a média de idade dos pacientes, assim como a localização anatômica e a manifestação clínica das LLO são diferentes do LPO, e podem ajudar a melhor caracterizar este grupo de condições. Espécimes diagnosticados como LPO-C mostraram parâmetros clínicos mais próximos ao LPO.

Abstract The clinicopathological features that precisely characterize oral lichen planus (OLP) and oral lichenoid lesions (OLL) still represent a challenge. The aim of the present study was to analyze, from an oral pathologist perspective, the clinical features from OLP and OLL. Specimens fullfilling the histological criteria for OLP and OLL, and also compatible with OLP (OLP-C), were selected and clinical information was retrieved from the laboratory forms. The final sample was composed by 221 cases, including 119 OLP (53.8%), 65 OLP-C (29.4%) and 37 OLL (16.7%). Females were more affected in the three groups, but the number of males was higher in OLL. Mean age was lower in OLP (52.3 years) in comparison with OLL (57.9 years) (p=0.020). Buccal mucosa and tongue involvement was more frequent in OLP; gingival involvement was uncommon in OLL. The reticular pattern was more frequently found in OLP, while the association of reticular and atrophic/erosive/ulcerated patterns was more common in OLP-C and OLL (p=0.025). In conclusion, gender and mean age of the patients, and anatomical location and clinical manifestation of OLL are different from OLP, and could help to better characterize this group of conditions. Specimens diagnosed as OLP-C showed clinical parameters close to OLP.

https://doi.org/10.1590/0103-6440202204426

How to manage lymphoid malignancies during novel 2019 coronavirus (CoVid-19) outbreak: a Brazilian task force recommendation
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Perini, Guilherme Fleury

; Fischer, Thais

; Gaiolla, Rafael Dezen

; Rocha, Talita Bueno

; Bellesso, Marcelo

; Teixeira, Larissa Lane Cardoso

; Delamain, Marcia Torresan

; Scheliga, Adriana Alves de Souza

; Ribeiro, Glaciano Nogueira

; Vaz Neto, Jorge

; Baiocchi, Otávio Cesar Carvalho Guimaraes

; Abdo, André Neder Ramires

; Arrais-Rodrigues, Celso

; Fogliatto, Laura M.

; Bigni, Ricardo de Sá

; Schaffel, Rony

; Biasoli, Irene

; Pereira, Juliana

; Nabhan, Samir Kanaan

; Souza, Cármino Antônio de

; Chiattone, Carlos Sérgio

Hematology, Transfusion and Cell Therapy

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jun 2020, Volume 42 N. 2 Pages 103 - 110

Abstract: En | Text: En | PDF: En

ABSTRACT: The novel Coronavirus (CoVid-19) outbreak is now consider a world pandemic, affecting more than 1,300,000 people worldwide. Cancer patients are in risk for severe disease, including a higher risk of intensive care unit (ICU) admission, need for invasive ventilation or death. Management of patients with lymphoid malignancies can be challenging during the outbreak, due to need of multiple hospital visits and admissions, immunosuppression and need for chemotherapy, radiotherapy and stem cell transplantation. In this article, we will focus on the practical management of patients with lymphoid malignancies during the COVID-19 pandemic, focusing on minimizing the risk for patients.

https://doi.org/10.1016/j.htct.2020.04.002 435 downloads

Population fluctuation of fruit fly Anastrepha spp. (Díptera: Tephritidae) in guava (Psidium guajava L.) accesses produced in organic system
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Galli, Juliana Altafin

; Michelotto, Marcos Doniseti

; Bernardes-Soares, Maria Beatriz

; Mello-Martins, Antonio Lucio

; Fischer, Ivan Herman

Acta Agronómica

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jun 2019, Volume 68 N. 1 Pages 9 - 15

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La guayaba (Psidium guajava L.) sobresale entre las frutas tropicales, no obstante los volúmenes de sus exportaciones desde Brasil son bajos, debido al ataque de plagas cuarentenarias, entre ellas, la mosca de la fruta (Anastrepha spp.). La presente investigación tuvo como objetivo evaluar la fluctuación de la población de esta plaga y la infestación de frutos causada en accesiones de guayaba cultivadas en sistema orgánico, y evaluar las posibles correlaciones con los factores cimáticos. Para estimar la fluctuación de la población, se utilizaron 20 trampas atrayentes amarillas. Las revisiones se iniciaron en abril de 2013 y se hicieron durante 378 días. Las trampas se mantuvieron en el campo durante toda la etapa experimental y fueron revisadas y reemplazadas cada 14 días. Los datos fueron analizados por correlaciones simples entre las poblaciones de moscas de la fruta, la temperatura y la precipitación. Para los conteos se utilizaron 9 frutos por accesión en la fase de de maduración, los cuales fueron llevados al laboratorio y evaluados para infestación mediante corte longitudinal. Los promedios se compararon por la prueba de Scott-Knott al 5% de probabilidad. Los resultados mostraron que, el género Anastrepha presentó una alta población en los accesos evaluados, independiente de los factores de clima. También se encontraron algunos individuos de la especie Ceratitis capitata . No obstante los accesos IAC-4-Cica y Taquaritinga Comum, ambos rojos, no presentaron frutas infestadas; por su parte, los accesos Torráo de Ouro, Supreme BA, L2P4 y Supreme, mostraron bajas cantidades de fruta atacada.

Abstract Guava (Psidium guajava L.) presented prominence among the tropical fruit. Guava exports are still unimpressive, because of the quarantine pests, among them the fruit flies. The present research had as objective to evaluate the population fluctuation of fruit flies Anastrepha spp. and the fruits infestation caused in guava accesses cultivated in organic system, and study the possible correlations between this pest and meteorological factors. To estimate population fluctuation, 20 yellow sticky traps were used. The reviews were initiated in April 2013, for 378 days. The traps were kept in the field for the entire duration of the experiment, and they were reviewed every 14 days in most cases, during replacement of traps for new ones. With the data, simple correlations were calculated between the fruit flies of the genus Anastrepha spp., the temperature, and precipitation. Nine fruits per accession, at the stage of maturation, were taken to the laboratory and evaluated for fruit fly infestation by the longitudinal cutting of fruit. The averages were compared by the Scott-Knott test at 5% probability. The genus Anastrepha was found in greater quantity, and there is no correlation between the meteorological factors and population fluctuation of Anastrepha . Also was found some individuals of the species Ceratitis capitata . Most of the fruits of the evaluated accesses presented high infestations by fruit flies. Accesses IAC - 4 - Cica noteworthy for not presenting any infested fruit, without differing from accesses Taquaritinga Comum, both red. The accesses Torráo de Ouro, Supreme BA, L2P4, and Supreme, also showed low numbers of fruit attacked.

https://doi.org/10.15446/acag.v68n1.66263 458 downloads

Attractive lures for fruit flies in an organic guava orchard
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Galli, Juliana Altafin

; Michelotto, Marcos Doniseti

; Carrega, Willians Cesar

; Fischer, Ivan Herman

Arquivos do Instituto Biológico

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2019, Volume 86 elocation e0682018

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A presença de mosca-das-frutas é o maior obstáculo à produção de goiabas, sendo o monitoramento populacional de fundamental importância para seu manejo. O objetivo deste trabalho foi avaliar a eficácia de iscas atrativas para mosca-das-frutas em goiabeiras, produzidas em um sistema orgânico. Foram instaladas armadilhas McPhail contendo 400 mL de solução, em quatro repetições e distribuição em blocos randomizados, em seis tratamentos: isca Mosca® (5%); isca Samaritá Tradicional® (5%); levedura Torula®; Bio Anastrepha® (5%); Ceratrap® e suco de goiaba (50%), com 3 avaliações semanais. Os dados da captura foram submetidos à análise de variância e às médias comparadas (Tukey 5%). Os valores de Mosca por Armadilha por Dia (MAD) foram calculados. A correlação entre moscas e as variáveis meteorológicas foi avaliada e o custo mensal das iscas foi calculado. Foram coletados 37.917 indivíduos do gênero Anastrepha e 122 moscas da espécie Ceratitis capitata, sendo a Anastrepha spp. o principal gênero de mosca-das-frutas da região. O produto Ceratrap mostrou-se superior, seguido pelas iscas Torula, Isca Mosca e Bio Anastrepha; a Isca Samaritá e o suco de goiaba apresentaram os menores resultados de captura. O padrão de captura de fêmeas foi semelhante ao total. Verificou-se uma queda na uniformidade de atração de todos os tratamentos, sendo o Ceratrap o que apresentou maior constância após sete dias. As correlações entre os fatores meteorológicos e a flutuação populacional foram positivas e significativas apenas para a precipitação. Os tratamentos mais onerosos (Ceratrap e Torula) também foram os mais eficientes e seletivos, sendo o produto Ceratrap o que demandou menor mão de obra.

ABSTRACT Fruit flies are the biggest obstacle in guava cultivation, with the monitoring of population a fundamental aspect for their management. The objective of this study was to assess the effectiveness of attractive lures for fruit flies in guava trees, produced in an organic system. McPhail traps were installed with 400 mL of solution, in four repetitions, and distributed in randomized blocks in six treatments: Isca Mosca® (5%); Isca Samaritá Tradicional® (5%); Torula® yeast; Bio Anastrepha® (5%); Ceratrap® and guava juice (50%), with 3 weekly reviews. Data on capture were subjected to analysis of variance, and averages were compared (Tukey 5%). The values of fly trap per day (FTD) were computed. The correlation between flies and meteorological variables were evaluated, as well as the monthly cost of lures. A total of 37,917 individuals from the genus Anastrepha and 122 species of flies Ceratitis capitata were collected, being Anastrepha spp. the main genus of fruit fly in the region. The Ceratrap product proved to be superior, followed by Torula, Isca Mosca, and Bio Anastrepha; Isca Samaritá and guava juice presented the lowest results. The standard trapping of females was like the total. The uniformity of attraction presented a drop in all treatments, and Ceratrap was more constant after seven days. The correlations between meteorological factors and population variation were positive and significant only for precipitation. The most expensive treatments (Ceratrap and Torula) were also the most efficient and selective, and the Ceratrap product required less manpower.

https://doi.org/10.1590/1808-1657000682018 795 downloads

Bem-estar em invertebrados: um parâmetro ético de responsabilidade científica e social da pesquisa?
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Fischer, Marta Luciane

; Zacarkin Santos, Juliana

Revista Latinoamericana de Bioética

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jun 2018, Volume 18 N. 1 Pages 18 - 35

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Nuestro objetivo fue evaluar la promoción del bienestar de invertebrados utilizados en la investigación a través de su representación en la comunidad científica, la difusión de las investigaciones y la inclusión en los debates éticos. El análisis arrojó como resultado el predominio de los enfoques biológicos, utilitaristas en animales de interés médico y económico, cuya insipiencia de informaciones sobre las condiciones de obtención, manipulación y experimentación comprometen la reproducibilidad y desarrollo del área. Se discute la inclusión de los invertebrados en los debates éticos cuya reivindicación de normas y protección, demanda la instrumentalización del investigador en busca de la excelencia técnica y ética en la planificación, ejecución y difusión de sus investigaciones, con el fin de fortalecer el contrato social y científico generador de beneficios para la ciencia y para la calidad de vida del animal.

Abstract We aimed to evaluate the promotion of the welfare of invertebrates used in research through their representation in the scientific community, the dissemination of research and inclusion in ethical debates. The analysis resulted in the predominance of biological, utilitarian approaches in animals of medical and economic interest, whose incipience of information on the conditions of collecting, manipulation, and experimentation compromise the reproducibility and development of the area. It is discussed the inclusion of the invertebrates in the ethics debates, whose claim for standards and protection, demands the exploitation of the researcher in search of technical and ethical excellence in the planning, execution and dissemination of his research to strengthen the social and scientific contract generator of benefits to science and to the animal's quality of life.

Resumo Objetivou-se avaliar a promoção do bem-estar de invertebrados usados em pesquisa por meio da sua representação no meio científico, divulgação das pesquisas e inclusão nos debates éticos. A análise atestou predomínio de abordagens biológicas, utilitaristas em animais de interesse médico e economico, cuja incipiência de informações sobre as condições de obtenção, manipulação e experimentação comprometem a reprodutibilidade e desenvolvimento da área. Discute-se a inclusão dos invertebrados nos debates éticos cuja reivindicação de normatizações e proteção, demanda a instrumentalização do pesquisador em busca pela excelência técnica e ética no planejamento, execução e divulgação de sua pesquisa a fim de fortalecer o contrato social e cientifico gerador de benéficos para ciência e para qualidade de vida do animal.

https://doi.org/10.18359/rlbi.2865 1157 downloads

EFFECT OF CONVENTIONAL AND ALTERNATIVE PRODUCTS ON POSTHARVEST DISEASE CONTROL IN AVOCADOS
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Fischer, Ivan Herman

; Moraes, Matheus Froes de

; Palharini, Maria Cecília de Arruda

; Fileti, Mirian de Souza

; Cruz, Juliana Cristina Sodário

; Firmino, Ana Carolina

Revista Brasileira de Fruticultura

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2018, Volume 40 N. 1 elocation e-408

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Um dos grandes problemas na comercialização de abacates é a incidência de doenças pós-colheita. Objetivou-se avaliar o efeito de produtos convencionais e alternativos no controle de doenças em abacates ‘Hass’, em condições de campo e em pós-colheita, realizando a caracterização físico-química nos frutos submetidos aos tratamentos pós-colheita. No campo, em adição ao manejo do produtor, foram avaliados sete produtos, pulverizados três vezes durante a frutificação. Os produtos em pós-colheita foram diluídos em água ou em cera de polietileno oxidada e goma laca. Os tratamentos em água com fosfito de potássio, Soil-Set®, dióxido de cloro, óleo essencial de tomilho, bicarbonato de sódio, óleo essencial de capim limão e tiabendazol reduziram a incidência de frutos doentes, sendo a antracnose, principal doença, controlada com bicarbonato de sódio, óleo essencial de capim limão e tiabendazol. Maior teor de sólidos solúveis foi constatado nos tratamentos água, dióxido de cloro, acibenzolar-S-metílico e tiabendazol. Os produtos que reduziram a antracnose não apresentaram correlação entre a incidência da doença com os parâmetros físico-químicos, evidenciando que o controle não está associado ao atraso no amadurecimento. Nos tratamentos em cera não ocorreu controle das doenças, sendo observado menor acidez titulável com óleo essencial de tomilho, bicarbonato de sódio, controle (cera), acibenzolar-S-metílico e óleo essencial de capim limão. Os tratamentos controle e óleo essencial de tomilho destacaram-se pela menor manutenção da coloração verde da casca dos frutos. Em condições de campo, os produtos azoxistrobina, tiabendazol, difenoconazol+azoxistrobina e acibenzolar-S-metílico+azoxistrobina, reduziram a ocorrência de frutos doentes, sendo que controle da antracnose ocorreu apenas com azoxistrobina.

ABSTRACT Postharvest diseases constitute a serious problem for avocado commercialization. Thus, the present study aimed to evaluate the effect of conventional and alternative products in controlling diseases affecting ‘Hass’ avocados in the field and in the postharvest by carrying out physicochemical characterization of fruits subjected to postharvest treatments. In the field, besides the management adopted by the farmer, seven products were sprayed three times during fruiting for evaluation. Postharvest products were diluted in water or in oxidized polyethylene wax and shellac. Water treatments with potassium phosphite, Soil-Set®, chlorine dioxide, thyme essential oil, sodium bicarbonate, lemon grass essential oil and thiabendazole reduced the incidence of diseased fruits, and anthracnose, the main disease, was controlled with sodium bicarbonate, lemon grass essential oil and thiabendazole. Greater soluble solids content was found for control (water), chlorine dioxide, acibenzolar-S-methyl and thiabendazole. For the products that reduced anthracnose, there was no correlation between the disease and the physicochemical parameters, evidencing that the disease control is not associated with delayed ripening. For wax treatments, diseases were not controlled, and the fruits presented lower titratable acidity with thyme essential oil, sodium bicarbonate, control (wax), acibenzolar-S-methyl and lemon grass essential oil. Control and thyme essential oil were highlighted for maintaining the green coloration of the fruit skin for the shortest period. Under field conditions, azoxystrobin, thiabendazole, difenoconazole+azoxystrobin and acibenzolar-S-methyl+azoxystrobin reduced the occurrence of diseased fruits, while anthracnose control was only obtained with azoxystrobin.

https://doi.org/10.1590/0100-29452018408 2850 downloads

CORRELATION AMONG DAMAGES CAUSED BY YELLOW BEETLE, CLIMATOLOGICAL ELEMENTS AND PRODUCTION OF GUAVA ACCESSES GROWN IN ORGANIC SYSTEM
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GALLI, JULIANA ALTAFIN

; MICHELOTTO, MARCOS DONISETI

; FISCHER, IVAN HERMAN

; SOARES, MARIA BEATRIZ BERNARDES

; MARTINS, ANTÔNIO LUCIO MELLO

Revista Brasileira de Fruticultura

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aug 2017, Volume 39 N. 3 elocation e-987

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo deste trabalho foi avaliar os danos ocasionados pelo besouro amarelo em 85 acessos de goiabeira e as correlações dos mesmos com os elementos climatológicos e a produção, em um pomar de goiaba conduzido em sistema orgânico. Foram analisadas 10 folhas por acesso contendo a injúria do ataque do inseto. Cada folha foi medida com medidor de área foliar e, após a obtenção da área total, a folha foi coberta com fita adesiva, e medida novamente. As médias foram comparadas pelo teste de Scott-Knott, a 5% de probabilidade. Os 15 acessos com maior média de danos tiveram os dados submetidos à correlação com a temperatura mínima e máxima, a precipitação e a umidade relativa. A produção foi obtida pelo número de frutos/planta. Os danos mostraram-se correlacionados negativamente com a média da umidade relativa das 7 h no período de 14 dias que antecedem as avaliações, afetando negativamente a produção de frutos. Os acessos Saito, L4P16, Monte Alto Comum 1 e L5P19 são promissores na agricultura orgânica, por apresentarem boa produção e menor dano ao ataque do inseto, quando comparados aos demais.

ABSTRACT The objective of this research was evaluate the damage caused by the yellow beetle on 85 guava accessions and correlations of the damage with the climatological elements and the production of fruit in an orchard of guava conducted in organic system. Ten leaves by access were analyzed containing the injury of insect attack. Each leaf had its foliar area measured by leaf area meter and, after obtaining the total area, the leaf was covered with duct tape, and measure again. The averages were compared by Scott-Knott test at 5% probability. The 15 accessions with highest average damage had the data submitted to the correlation with the minimum and maximum temperature, precipitation and relative humidity. The production was obtained by the number of fruits/plant. The damages are negatively correlated with the mean relative humidity of 7:00h (local time) in the period of 14 days prior to the assessments, and negatively affect production. The accessions Saito, L4P16, Monte Alto Comum 1 and L5P19 are promising in organic agriculture, for presenting good production and minor damage to insect attack, when compared to others.

https://doi.org/10.1590/0100-29452017987 820 downloads

Da ética ambiental à bioética ambiental: antecedentes, trajetórias e perspectivas
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Fischer, Marta Luciane

; Cunha, Thiago

; Renk, Valquiria

; Sganzerla, Anor

; Santos, Juliana Zacarkin dos

História, Ciências, Saúde-Manguinhos

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apr 2017, Volume 24 N. 2 Pages 391 - 409

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A relação entre humano e ambiente torna-se problema ético no século XX, quando a aceleração do desenvolvimento econômico e científico acompanhou profundas alterações nos sistemas ecológicos globais. A ética ambiental reivindicou limites na relação dicotômica homem/natureza. Em 1970, Van Potter propôs a bioética como espaço interdisciplinar para o estudo da “sobrevivência humana”. Nos anos seguintes, a disciplina restringiu-se a conflitos clínicos e hospitalares, afastando-se das questões da ética ambiental. Este artigo analisa o conceito de “bioética ambiental” como perspectiva teórica que acompanha um processo de resgate histórico da abordagem de Van Potter da bioética, caracterizado pela perspectiva das dimensões interpessoais, socioeconômicas e políticas dos dilemas éticos ambientais.

Abstract The relationship between humans and the environment became an ethical problem in the twentieth century, when accelerated economic and scientific development was accompanied by profound alterations in global ecological systems. In response, environmental ethics called for limits in the dichotomous relationship between man and nature. In 1970, Van Potter proposed bioethics as the interdisciplinary study of “human survival.” Subsequently, the discipline focused on clinical and hospital conflicts. Environmental bioethics is analyzed in this article as a theoretical perspective that has historically drawn on Van Potter’s approach to bioethics, marked by the interpersonal, socioeconomic, and political dimensions of environmental ethical dilemmas.

https://doi.org/10.1590/s0104-59702017000200005 15868 downloads

10.

First report of Lasiodiplodia theobromae on Macadamia integrifolia in Brazil
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Fischer, Ivan Herman

; Perdona, Marcos José

; Cruz, Juliana Cristina Sodário

; Firmino, Ana Carolina

Summa Phytopathologica

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mar 2017, Volume 43 N. 1 Pages 70 - 70

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/0100-5405/169154 1240 downloads

11.

Effect of soybean hulls on blood biochemical profiles and body condition of dogs
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Scheraiber, Mariana

; Sabchuk, Tabyta Tamara

; Silva, Juliana Regina da

; Domingues, Lidiane Priscila

; Ramos, Tatiane Aparecida

; Félix, Ananda Portella

; Oliveira, Simone Gisele de

; Silva, Ana Vitória Fischer da

Revista Brasileira de Zootecnia

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dec 2016, Volume 45 N. 12 Pages 755 - 759

Abstract: En | Text: En | PDF: En

ABSTRACT The objective of this study was to evaluate the alterations in blood biochemical profiles and body condition of dogs after intake of the diet without soybean hull (0%SH) and with soybean hull (16%SH) replacing corn. Twelve Beagle dogs with ideal body condition score (BCS) (average: 5) were distributed in a completely randomized design (six animals per treatment) and received the daily amount of food according to the energy needs for maintenance (g/kg weight0.75). The animals were evaluated on days 0 and 28 in relation to the blood biochemical profiles and body measurements, such as: total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low density lipoprotein (VLDL), triglyceride (TAG), glucose, body weight (BW), body fat percentage (%BF), nape, rib, tail base (TB), chest, and abdomen with plicometer, and BCS (scale of 1, thin and 9, obese), canine body mass index (CBMI), and thickness of the adipose tissue of the seventh lumbar vertebra (L7) with ultrasonography. The data were analyzed by Student's t test. The variation (final - initial, mg/dL) of cholesterol (16.33 vs. 15.55), HDL (17.56 vs. 10.05), LDL (22.78 vs. 14.57), VLDL (-4.01 vs. -1.92), TAG (-20.11 vs. -11.66), and glucose (-16.77 vs. -20.31) of dogs fed 0%SH and 16%SH, respectively, showed no difference. The body measurement variation (cm) of TB (1.00 vs. -0.60) obtained a significant difference. The addition of soybean hull in the diet does not alter the blood biochemical profiles; however, it does decrease the deposition of lipids in subcutaneous tissue.

https://doi.org/10.1590/s1806-92902016001200004 1138 downloads

12.

Considerations about gastric cancer proteomics
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CARVALHO, CARLOS EDUARDO

; MCCORMICK, THAÍS MESSIAS

; CARVALHO, PAULO COSTA

; FISCHER, JULIANA DE SALDANHA DA GAMA

; AQUINO, PRISCILA FERREIRA DE

; BRAVO NETO, GUILHERME PINTO

; CARVALHO, MARIA DA GLÓRIA DA COSTA

Revista do Colégio Brasileiro de Cirurgiões

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oct 2016, Volume 43 N. 5 Pages 395 - 397

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A frequência de estudos moleculares visando a analisar os promotores de metilação de genes supressores de tumor e proteômica globais na carcinogênese gástrica está aumentando. No entanto, apenas alguns consideraram os diferentes tipos de células do estômago, a localização do tumor e a influência da infecção por Helicobacter pylori e pelo vírus Epstein-Barr (EBV). Diferenças moleculares relacionadas com áreas tumorais anatômicas e histológicas também foram recentemente descritas. Os autores propõem uma classificação molecular de câncer gástrico, dividindo-o em quatro subtipos: tumores positivos para o EBV; tumores microssatélite instáveis; tumores genomicamente estáveis e tumores com instabilidade cromossômica.

ABSTRACT The frequency of molecular studies aimed to analyze promoter methylation of tumor suppressor genes and global proteomics in gastric carcinogenesis is increasing. Nonetheless, only a few considered the different types of stomach cells, the tumor location and the influence of Helicobacter pylori and Epstein Barr virus infection (EBV). Molecular differences relating to anatomical and histological tumor areas were also recently described. The authors propose a molecular classification of gastric cancer, dividing it into four subtypes: tumors positive for EBV; microsatellite unstable tumors; genomically stable tumors and tumors with chromosomal instability.

https://doi.org/10.1590/0100-69912016005016 4157 downloads

13.

Anthropometric indicators of general and central obesity in the prediction of asthma in adolescents: central obesity in asthma
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Benedetti, Franceliane Jobim

; Bosa, Vera Lúcia

; Giesta, Juliana Mariante

; Fischer, Gilberto Bueno

Nutrición Hospitalaria

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dec 2015, Volume 32 N. 6 Pages 2540 - 2548

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Objective: to determine the prevalence of asthma risk associated with anthropometric indicators of excess weight and body fat distribution. Methodology: cross-sectional study including adolescents between 10 and 19 years of age. The anthropometric indicator used to classify excess weight was the body mass index (BMI-Z); those used for abdominal adiposity were waist circumference (WC), waist-to-height ratio (WHtR) and the conicity index (CI). Asthma characteristics were evaluated using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. The significance level was 5%, and the analyses were performed using Statistical Package for the Social Sciences (SPSS) Version 18.0. Results: adolescent students (n = 1362; 788 [57.9%] female) with a mean age of 15.65 ± 1.24 years were evaluated. A high prevalence of asthma, excess weight (BMI-Z) and excess abdominal adiposity (WC and WHtR) was observed in the females. Only CI values for excess abdominal adiposity were higher for males than for females. Adolescents with excess abdominal adiposity, as shown by the WHtR, had a 1.24 times higher risk of having asthma compared with non-obese adolescents. Boys with excess abdominal adiposity, as classified by CI, presented a 1.8 times greater risk of asthma. The risk of severe asthma was 3 times higher among adolescents who were classified as severely obese via the BMI-Z. Conclusion: this study showed that excess body weight and abdominal obesity are associated with an increased risk of asthma and asthma severity in adolescents. Thus, additional BMI measurements are suggested for asthmatics.

Objetivo: determinar la prevalencia de riesgo de asma asociado con indicadores antropométricos de exceso de peso y la distribución de la grasa corporal. Metodología: estudio transversal que incluye adolescentes entre 10 y 19 años de edad. El indicador antropométrico utilizado para clasificar el exceso de peso fue el índice de masa corporal (IMC-Z); los utilizados para la adiposidad abdominal fueron la circunferencia de la cintura (CC), la relación cintura-estatura (RCE) y el índice de conicidad (IC). Las características del asma se evaluaron utilizando el cuestionario International Study of Asthma and Allergies in Childhood (ISAAC). El nivel de significación fue del 5%, y los análisis se realizaron con el Statistical Package for the Social Sciences (SPSS) versión 18.0. Resultados: fueron evaluados estudiantes adolescentes (n = 1362; 788 [57,9%] mujeres) con una edad media de 15,65 ± 1,24 años. Se observó en las mujeres una alta prevalencia de asma, exceso de peso (IMC-Z) y exceso de adiposidad abdominal (WC y RCE). Solo los valores de IC para el exceso de adiposidad abdominal fueron mayores para los hombres que para las mujeres. Los adolescentes con exceso de adiposidad abdominal, como lo demuestra la RCE, tenían 1,24 veces más riesgo de tener asma en comparación con los adolescentes no obesos. Los niños con exceso de adiposidad abdominal, según la clasificación de IC, presentaron 1,8 veces mayor riesgo de asma. El riesgo de asma grave era 3 veces mayor entre las adolescentes que fueron clasificados como severamente obesos a través del IMC-Z. Conclusión: este estudio mostró que el exceso de peso y la obesidad abdominal se asocian con un mayor riesgo de asma y asma severa en adolescentes. Por lo tanto, se sugieren mediciones de IMC adicionales para los asmáticos.

https://doi.org/10.3305/nh.2015.32.6.9851 372 downloads

14.

Quantificação de doenças pós-colheita em acessos de goiabeira cultivados em sistema orgânico
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Galli, Juliana Altafin

; Fischer, Ivan Herman

; Palharini, Maria Cecília de Arruda

; Michelotto, Marcos Doniseti

Pesquisa Agropecuária Tropical

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jun 2015, Volume 45 N. 2 Pages 225 - 230

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Dentre as doenças que ocorrem na pós-colheita da goiaba, destacam-se a antracnose, a pinta preta e as podridões pedunculares. A incidência e a diversidade dessas doenças dependem do genótipo do hospedeiro. Este trabalho objetivou identificar e quantificar as doenças pós-colheita de acessos de goiabeira cultivados em sistema orgânico. Para a caracterização das doenças, avaliaram-se 30 frutos de 48 acessos, em delineamento inteiramente casualizado. A antracnose e a pinta preta foram as doenças pós-colheita mais frequentes na goiaba. Os acessos Vermelha Redonda (Shimoda), L5P21, L3P12, EEF-3, IAC-4 - Unesp e Monte Alto - Comum 1 destacaram-se por apresentarem as menores incidências de antracnose e pinta preta, enquanto L4P13, L1P2 e Creme Arredondada (Unesp) foram os que apresentaram as maiores incidências de antracnose, pinta preta e podridão peduncular. Os patógenos Fusicoccum sp., Phomopsis sp., Phoma sp., Dothiorella sp. e Lasiodiplodia sp. foram identificados como causadores de sintomas da podridão peduncular.

ABSTRACT Quantification of postharvest diseases of guava accessions cultivated in organic system Among the postharvest diseases that occur in guava, anthracnose, black spot and stem-end rot are the most common. The incidence and diversity of these diseases depend on the host genotype. This study aimed to identify and quantify the postharvest diseases of guava accessions cultivated in organic system. For the characterization of diseases, 30 fruits from 48 accessions were evaluated in a completely randomized design. Anthracnose and black spot were the most frequent postharvest diseases in guava. The Vermelha Redonda (Shimoda), L5P21, L3P12, EEF-3, IAC-4 -Unesp and Monte Alto -Comum 1 accessions stood out with the lowest incidence of anthracnose and black spot, while L4P13, L1P2 and Creme Arredondada (Unesp) showed the highest incidence of anthracnose, black spot and stem-end rot. The Fusicoccum sp., Phomopsis sp., Phoma sp., Dothiorella sp. and Lasiodiplodia sp. pathogens were identified as the main responsible for causing stem-end rot symptoms.

https://doi.org/10.1590/1983-40632015v4533713 1567 downloads

15.

Colorectal cancer DNA methylation patterns from patients in Manaus, Brazil
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Almeida, Fabiana Greyce Oliveira

; Aquino, Priscila Ferreira de

; Souza, Afonso Duarte Leäo de

; Souza, Antonia Queiroz Lima de

; Vinhote, Sonia do Carmo

; Mac-Cormick, Thais Messias

; Silva, Marcelo Soares da Mota

; Chalub, Sidney Raimundo Silva

; Fischer, Juliana de Saldanha da Gama

; Carvalho, Paulo Costa

; Carvalho, Maria da Gloria da Costa

Biological Research

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2015, Volume 48 Pages 1 - 6

Abstract: En | Text: En | PDF: En

BACKGROUND: DNA methylation is commonly linked with the silencing of the gene expression for many tumor suppressor genes. As such, determining DNA methylation patterns should aid, in times to come, in the diagnosis and personal treatment for various types of cancers. Here, we analyzed the methylation pattern from five colorectal cancer patients from the Amazon state in Brazil for four tumor suppressor genes, viz.: DAPK, CDH1, CDKN2A, and TIMP2 by employing a polymerase chain reaction (PCR) specific to methylation. Efforts in the study of colorectal cancer are fundamental as it is the third most of highest incidence in the world. RESULTS: Tumor biopsies were methylated in 1/5 (20 %), 2/5 (40 %), 4/5 (80 %), and 4/5 (80 %) for CDH1, CDKN2A, DAPK, and TIMP2 genes, respectively. The margin biopsies were methylated in 3/7 (43 %), 2/7 (28 %), 7/7 (100 %), and 6/7 (86 %) for CDH1, CDKN2A, DAPK, and TIMP2, respectively. CONCLUSIONS: Our findings showed DAPK and TIMP2 to be methylated in most samples from both tumor tissues and adjacent non-neoplastic margins; thus presenting distinct methylation patterns. This emphasizes the importance of better understanding of the relation of these patterns with cancer in the context of different populations.

https://doi.org/10.1186/S40659-015-0042-7 1110 downloads

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