Resumo A investigação sobre a aprendizagem musical tem mostrado que as atividades musicais em conjunto podem ter um impacto positivo na aprendizagem do instrumento de música. Neste contexto, um campo ainda pouco estudado são as aulas de grupo de instrumento, nomeadamente, como metodologia de apoio às aulas individuais. Por isso, neste artigo vai debater-se a pertinência da participação dos alunos em aulas de grupos de instrumento, e procurar entender se estas aulas podem ser um modo de desenvolver competências de performance, e outras, como o pensamento crítico. Foram realizados 16 questionários a alunos que frequentaram este tipo de aulas e 4 questionários a professores que as administraram. Foram observadas três aulas deste tipo numa instituição de ensino superior de música. Os dados qualitativos foram sujeitos ao que é chamado na literatura de “análise de padrão”, ou seja, analise à base da categorização dos dados recolhidos. Os resultados obtidos indicam que as aulas de grupo instrumentais são uma metodologia relevante de apoio à aprendizagem instrumental, nomeadamente, no auxílio à preparação da performance. Estas aulas ajudam os alunos a superar obstáculos - como aprender a lidar com o nervosismo - e ajuda-os a desenvolverem competências, como a concentração, competências metacognitivas e o pensamento crítico. As aulas de grupo mencionadas neste estudo permitem a simulação da performance real, o que constitui um momento de teste, correção, e avaliação do estado da preparação individual para a performance. A existência de feedback nestas aulas enriquece a aprendizagem, catalisa a aquisição de competências e ajuda os alunos a crescerem técnica, musical e humanamente.

Abstract The research on musical learning has shown that group musical activities can have a positive impact on the learning of an instrument music. In this context, a field still little studied is the instrumental group classes, namely as a methodology to support individual classes. So, this article discusses the relevance of having students engaging in such instrument group classes and seeks to understand whether these can be a way to develop performance skills, and others, such as critical thinking. Sixteen questionnaires were conducted to students who attended this type of classes and four questionnaires to teachers who gave them. Three classes of this kind were observed in a higher music institution. Qualitative data were subject to what is called in the literature as "pattern analysis", that is, analysis based on the categorization of the collected data. The results obtained indicate that instrumental group classes are a relevant methodology to support instrumental learning, namely in helping performance preparation. These classes help students to overcome obstacles - such as learning to deal with nervousness - and help them to develop skills such as concentration, metacognitive skills, and critical thinking. The group classes mentioned in this study allow the simulation of real performance, which creates a moment of testing, correction, and evaluating the state of the individual preparation for performance. The existence of feedback in these classes enriches learning, catalyzes the acquisition of skills, and helps students to grow technically, musically, and humanly.

Objectives: To determine the prevalence and correlates of treatment-resistant schizophrenia (TRS) through a systematic review and meta-analysis. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria, an electronic search was performed in PubMed and Embase through May 17, 2022. All study designs that assessed a minimum of 20 schizophrenia-spectrum patients and provided data on TRS prevalence or allowed its calculation were included. Estimates were produced using a random-effects model meta-analysis. Results: The TRS prevalence across 50 studies (n = 29,390) was 36.7% (95%CI 33.1-40.5, p < 0.0001). The prevalence ranged from 22% (95%CI 18.4-25.8) in first-episode to 39.5% (95%CI 32.2-47.0) in multiple-episode samples (Q = 18.27, p < 0.0001). Primary treatment resistance, defined as no response from the first episode, was 23.6% (95%CI 20.5-26.8) vs. 9.3% (95%CI 6.8-12.2) for later-onset/secondary (≥ 6 months after initial treatment response). Longer illness duration and recruitment from long-term hospitals or clozapine clinics were associated with higher prevalence estimates. In meta-regression analyses, older age and poor functioning predicted greater TRS. When including only studies with lower bias risk, the TRS prevalence was 28.4%. Conclusion: Different study designs and recruitment strategies accounted for most of the observed heterogeneity in TRS prevalence rates. The results point to early-onset and later-onset TRS as two separate disease pathways requiring clinical attention. Registration number: PROSPERO CRD42018092033.

Abstract In the studies on musical learning, group musical practice has not been the object of in-depth study. Little is currently known about the impact of playing in an orchestra on students' motivation or learning to study the instrument. In this study, the objective was to understand the phenomenon of musical practice in orchestra to answer the research questions: Does playing in an orchestra generate intrinsic motivation in students? Does it have implications for individual learning and study of the instrument? Semi-structured interviews were conducted with 15 orchestral students to learn the attitude, feelings and perceptions of the students involved. The content analysis involved: (1) a systematic approach to the data analysis process; (2) the use of data reduction methods; and 3) coding the data into categories. This categorization resulted in what is called “pattern analysis.” The qualitative data analysis indicates that students feel motivated for orchestral practice and that playing in the orchestra can positively affect the student's learning and motivation. The orchestra practice seems to increase the practice time and help develop musical and social skills. Self-determination theory is the one that explains the obtained results. According to this theoretical perspective, to feel motivated for a given task, the individual must fulfil three basic psychological needs: autonomy, competence, and establishment of social bonds. For the students, playing in orchestra seems to be a favorable context for developing autonomy, perception of competence, and establishing social bonds with their peers. Playing in orchestra seems to be the challenge in which the balance between the perception of the difficulty of the task and the perception of being competent to perform it successfully is present. That is an excellent level of challenge.

ABSTRACT Background: New-onset chronic pain has been acknowledged as part of the post-COVID-19 condition. However, available fine-grained data about its clinical phenotype, trajectories and main associated characteristics remain scarce. We described the distinct temporal evolutions of post-COVID-19 pain and their epidemiological and phenotypical features. Methods: A prospective cross-sectional study enrolled post-COVID-19 condition patients (i.e. who had persisting COVID-19-related symptoms over 30 days since their first positive laboratory test), whose COVID-19 diagnosis had been supported by RT-PCR of oral/nasopharyngeal swab or serology. They underwent in-person evaluations with a structured interview, pain and quality-of-life-related questionnaires and thorough physical examination. Chronic pain (CP) and probable neuropathic pain (NP) were defined according to IASP criteria. Results: The present study included 226 individuals, 177 (78.3 %) of whom presented over 3 months since their first COVID-19 symptom. New-onset pain occurred in 170 (75.2 %) participants and was chronic in 116 (68.2 %). A chronic course was associated with COVID-19-related hospitalization, new-onset fatigue, lower cognitive performance, motor and thermal sensory deficits, mood and sleep impairments and overall lower quality-of-life levels. Probable NP occurred in only 7.6 % new-onset pain patients, and was associated with pain chronification, new-onset fatigue, motor and thermal sensory deficits, mechanical allodynia and lower rates of SARS-CoV-2 vaccination. Previous CP was reported by 86 (38.1 %) individuals and had aggravated after the infection in 66 (76.7 %) of them, which was associated with orthostatic hypotension. Conclusions: Post-COVID pain phenomena follow different paths, which are associated with specific clinical and epidemiological features, and possibly distinct underlying mechanisms, prognostic and therapeutic implications. Significance: COVID-19-related pain usually follows a chronic course and is non-neuropathic. Its possible courses and phenotypes are associated with distinct clinical and epidemiological features. This suggests differing underlying mechnisms, which may have significant prognostic and therapeutic implications.

RESUMEN Antecedentes: El dolor crónico de nueva aparición se considera que forma parte de la condición o afección post-COVID-19. Sin embargo, los datos detallados existentes sobre el fenotipo clínico, las trayectorias y las principales características asociadas siguen siendo escasos. Describimos las distintas evoluciones temporales del dolor post-COVID-19 y sus rasgos epidemiológicos y fenotípicos. Métodos: Estudio prospectivo y transversal de pacientes con afección post-COVID-19 (es decir, con síntomas persistentes relacionados con la COVID-19 durante 30 días desde la primera prueba positiva de laboratorio) cuyo diagnóstico de COVID-19 estuviera basado en la RT-PCR de un frotis oral/nasofaríngeo o una serología. Se sometieron a evaluaciones presenciales mediante una entrevista estructurada, cuestionarios de dolor y calidad de vida y una exploración física exhaustiva. El dolor crónico (DC) y el dolor neuropático (DN) probablemente se definieron conforme a los criterios IASP. Resultados: El presente estudio incluyó 226 individuos, 177 (78,3 %) de los cuales se presentaron pasados más de 3 meses desde el primer síntoma de COVID-19. Tenían dolor de nueva aparición 170 (75,2 %) de los participantes y dolor crónico 116 (68,2 %). El curso crónico se asociaba a hospitalización por COVID-19, fatiga de nueva aparición, menor rendimiento cognitivo, déficits motores y sensitivos térmicos, alteraciones del ánimo y el sueño, y niveles generalmente inferiores de calidad de vida. El DN probable afectaba a solo el 7,6 % de los pacientes con dolor de nueva aparición y se asociaba a cronificación del dolor, fatiga de nueva aparición, déficits motores y de sensación térmica, alodinia mecánica y tasas menores de vacunación frente al SARS-CoV-2. Referían DC previo 86 (38,1 %) individuos, y este había empeorado tras la infección en 66 (76,7 %) de ellos, lo que se asociaba a hipotensión ortostática. Conclusiones: Los fenómenos dolorosos post-COVID siguen diferentes trayectorias que se asocian a rasgos clínicos y epidemiológicos específicos, y posiblemente a distintos mecanismos de base y diferentes implicaciones pronósticas y terapéuticas. Significado: El dolor relacionado con la COVID-19 sigue normalmente un curso crónico y no es neuropático. Los posibles cursos y fenotipos se asocian a rasgos clínicos y epidemiológicos distintos. Esto sugiere que los mecanismos de base difieren, lo que podría tener implicaciones pronósticas y terapéuticas importantes.

SUMMARY OBJECTIVE: The aim of this study was to evaluate serum 25(OH)D concentrations in the homebound elderly people and relate them to level of dementia, nutritional risk, and route of dietary administration. METHODS: This is a cross-sectional study involving 207 bedridden elderly people assisted by the Home Care Service in the city of Santo André – SP, from June to December 2016. The following factors were evaluated: dietary intake of vitamin D, arm circumference, triceps skin fold thickness, calf circumference, nutritional risk by Mini-Nutritional Assessment, level of dementia by the adapted Clinical Dementia Rating questionnaire, and laboratory tests such as serum concentrations of 25(OH)D, ultrasensitive C-reactive protein, alkaline phosphatase, serum calcium, and parathormone. RESULTS: The mean age of the elderly people was 81.6 (9.2) years. Deficiency of 25(OH)D was observed in 76.3% of the elderly people. There was an inverse correlation between serum concentrations of 25(OH)D: parathormone (r=-0.418, p<0.001) and alkaline phosphatase (r=-0.188, p=0.006) and a direct correlation with serum calcium (r=-0.158, p=0.022). Logistic regression showed that vitamin D deficiency was directly and independently associated with oral feeding (odds ratio 7.71; 95%CI 2.91–20.40). CONCLUSION: Bedridden households showed high prevalence of vitamin D deficiency without association with nutritional risk and level of dementia. Oral diet was associated with vitamin D deficiency, possibly due to low consumption of source foods.

ABSTRACT BACKGROUND: Achalasia is an esophageal motility disorder, and myotomy is one of the most used treatment techniques. However, symptom persistence or recurrence occurs in 9 to 20% of cases. AIMS: This study aims to provide a practical approach for managing the recurrence or persistence of achalasia symptoms after myotomy. METHODS: A critical review was performed to gather evidence for a rational approach for managing the recurrence or persistence of achalasia symptoms after myotomy. RESULTS: To properly manage an achalasia patient with significant symptoms after myotomy, such as dysphagia, regurgitation, thoracic pain, and weight loss, it is necessary to classify symptoms, stratify severity, perform appropriate tests, and define a treatment strategy. A systematic differential diagnosis workup is essential to cover the main etiologies of symptoms recurrence or persistence after myotomy. Upper digestive endoscopy and dynamic digital radiography are the main tests that can be applied for investigation. The treatment options include endoscopic dilation, peroral endoscopic myotomy, redo surgery, and esophagectomy, and the decision should be based on the patient’s individual characteristics. CONCLUSIONS: A good clinical evaluation and the use of proper tests jointly with a rational assessment, are essential for the management of symptoms recurrence or persistence after achalasia myotomy.

RESUMO RACIONAL: A acalasia é um distúrbio da motilidade esofágica e a miotomia é uma das técnicas de tratamento mais utilizadas. No entanto, a persistência ou recorrência dos sintomas ocorre em 9 a 20%. OBJETIVOS: Este estudo visa fornecer uma abordagem prática para o manejo da recorrência ou persistência dos sintomas de acalasia após miotomia. MÉTODOS: Foi realizada uma revisão crítica para reunir evidências para uma abordagem racional no manejo da recorrência ou persistência dos sintomas de acalasia após miotomia. RESULTADOS: Para o manejo adequado de um paciente com acalásia com sintomas significativos após miotomia, como disfagia, regurgitação, dor torácica e perda de peso, é necessário classificar os sintomas, estratificar a gravidade, realizar exames adequados e definir uma estratégia de tratamento. Uma investigação diagnóstica diferencial sistemática é essencial para cobrir as principais etiologias de recorrência ou persistência dos sintomas após a miotomia. A endoscopia digestiva alta e a radiografia digital dinâmica são os principais exames que podem ser aplicados para investigação. As opções de tratamento incluem dilatação endoscópica, POEM (miotomia endoscópica oral), remiotomia e esofagectomia, e a decisão deve ser baseada nas características individuais do paciente. CONCLUSÕES: Uma boa avaliação clínica e a utilização de exames adequados, juntamente com uma avaliação racional, são essenciais para o manejo da recorrência ou persistência dos sintomas após miotomia por acalasia.

Abstract Inducible nitric oxide synthase (iNOS) is one of the enzymes responsible for the synthesis of nitric oxide (NO), which is an important signaling molecule with effects on blood vessels, leukocytes, and bone cells. However, the role of iNOS in alveolar bone healing remains unclear. This study investigated the role of iNOS in alveolar bone healing after tooth extraction in mice. Methodology C57Bl/6 wild type (WT) and iNOS genetically deficient (iNOS-KO) mice were subjected to upper incision tooth extraction, and alveolar bone healing was evaluated by micro-computed tomography (μCT) and histological/histomorphometric, birefringence, and molecular methods. Results The expression of iNOS had very low control conditions, whereas a significant increase is observed in healing sites of WT mice, where iNOS mRNA levels peak at 7d time point, followed by a relative decrease at 14d and 21d. Regarding bone healing, both WT and iNOS-KO groups showed the usual phases characterized by the presence of clots, granulation tissue development along the inflammatory cell infiltration, angiogenesis, proliferation of fibroblasts and extracellular matrix synthesis, bone neoformation, and remodeling. The overall micro-computed tomography and histomorphometric and birefringence analyses showed similar bone healing readouts when WT and iNOS-KO strains are compared. Likewise, Real-Time PCR array analysis shows an overall similar gene expression pattern (including bone formation, bone resorption, and inflammatory and immunological markers) in healing sites of WT and iNOS-KO mice. Moreover, molecular analysis shows that nNOS and eNOS were significantly upregulated in the iNOS-KO group, suggesting that other NOS isoforms could compensate the absence of iNOS. Conclusion The absence of iNOS does not result in a significant modulation of bone healing readouts in iNOS-KO mice. The upregulation of nNOS and eNOS may compensate iNOS absence, explaining the similar bone healing outcome in WT and iNOS-KO strains.

abstract: In this work, the authors explore the use of iron ore tailings (IOT) from a tailings dam as a recycled precursor material in producing a composite through alkali-activation technology. Two different composite types were evaluated: paste specimens made using only IOT and an alkaline activator, and mortar specimens using the same binder and quartz sand as fine aggregate. Three different grinding times were applied to activate the IOT; a NaOH solution was used as the alkaline activator with three molar concentrations (8, 10, and 12 mol/l); and, thermal curing of 100°C for 7 days was applied. These parameters were obtained by a hard-mini-test (HMT) experimental procedure. The physico-mechanical properties of the composites were obtained, and the results showed a compressive strength up to 110.0 MPa, which is like high-performance Portland cement concretes and alkali-activated cements derived from well-established precursors reported in the literature using thermal cure.

resumo: Neste trabalho, os autores exploram o uso do rejeito de barragem de minério de ferro (RBMF), de uma barragem de rejeitos, como material precursor reciclado na produção de um compósito através da tecnologia de ativação alcalina. Dois compósitos diferentes foram avaliados: espécimes de pastas feitas usando somente RBMF e ativador alcalino, e espécimes de argamassa usando o mesmo aglomerante e areia como agregado miúdo. Três tempos de moagem diferentes foram aplicados para ativar o RBMF; uma solução de NaOH foi empregada como ativador alcalino com três concentrações molares (8, 10 e 12 mol/l); e cura térmica de 100ºC por 7 dias. Esses parâmetros iniciais foram obtidos através do procedimento experimental Endurecimento-Mini-Teste (EMC). As propriedades físico-mecânicas dos compósitos foram determinadas e os resultados mostraram uma resistência a compressão de até 110,0 MPa, que é compatível com concreto de cimento Portland de alto desempenho e cimentos álcali-ativados feitos a partir de precursores bem estabelecidos reportados na literatura usando cura térmica.

Abstract Anthropogenic interventions in the natural landscape became recurrent from the expansion of nuclei and population increase, causing the relationship established between human beings and nature to move away from the naturalist model and assume an interventionist premise. Among the various interferences in the natural environment, this work establishes a spatial cut in the urban river landscape changes, in particular, those caused by processes of rectification, canalization and plugging of urban rivers. The denaturalization and mischaracterization of this system means that the existence of urban rivers have been ignored, acquiring notoriety only when natural processes, intensified by human beings, cause damage or disaster to the population that usually occupies the floodplain areas. Thus, recognizing these changes and rescuing the relationship of belonging to this environment, which initially supported the formation of most urban centers, becomes essential for local landscape and urban planning. Based on this understanding, this study aimed to carry out a survey of the changes in the river landscape of the São João del-Rei city - Minas Gerais. For this purpose, the descriptive investigative method was used, which made possible the elaboration of a case study. The results obtained by the research indicate that the river landscape has been significantly altered, especially by rectifications, canalizations and plugging of urban rivers, which are presented in a historical context and related to the processes and dynamics of urban waters.

Resumo As intervenções antrópicas na paisagem natural tornaram-se recorrentes a partir da expansão dos núcleos e aumento populacional, fazendo com que a relação estabelecida entre o ser humano e a natureza se distanciasse do modelo naturalista e assumisse uma premissa intervencionista. Dentre as diversas interferências no meio natural, este trabalho estabelece um recorte espacial sobre as modificações na paisagem fluvial urbana, em particular, nas ocasionadas pelas retificações, canalizações e tamponamentos dos rios urbanos. A desnaturalização e descaracterização desse sistema faz com que a existência dos corpos hídricos seja ignorada, adquirindo notoriedade apenas quando processos de ordem natural, intensificados pelo ser humano, acarretam prejuízos ou desastres à população que, habitualmente, ocupa as áreas de várzea. Desse modo, reconhecer as referidas modificações e resgatar a relação de pertencimento com esse ambiente que, inicialmente, deu suporte à formação da maioria dos núcleos urbanos, torna-se essencial ao planejamento da paisagem local e ordenamento urbano. A partir desse entendimento, este estudo teve como objetivo efetuar um levantamento das modificações na paisagem fluvial da cidade de São João del-Rei - Minas Gerais. Para isso, foi empregado o método descritivo investigativo para a elaboração de um estudo de caso. Os resultados obtidos indicam que a paisagem fluvial da cidade em questão foi significativamente alterada, sobretudo por retificações, canalizações e tamponamento dos rios urbanos, os quais são apresentados em um contexto histórico e relacionados aos processos e a dinâmica das águas urbanas.

Abstract The aim of this study is to report an original case series of synchronous jawbone diseases. Data of patients seen over 13 years were extracted from the files of three Oral Radiology and Pathology diagnostic centers in Brazil. The clinical, radiographic, and laboratory characteristics were tabulated and analyzed by the authors; the patients were described according to lesion type. Seventy-two synchronous jawbone diseases were included in this study. Florid osseous dysplasia, Gorlin-Goltz syndrome, and cherubism were the most frequent disorders reported in this case series. In addition, the posterior mandible area was the main site of manifestation. Florid osseous dysplasia and Gorlin-Goltz syndrome represented two-thirds of our samples. With the utilization of adequate demographic, clinical, and radiologic information, it is possible to diagnose most of the synchronous lesions of jawbones. Sometimes, however, we need complementary exams, such as histopathologic and biochemical analysis or dosing of calcium, phosphorus, and alkaline phosphatase.

Abstract Neurofibromatosis Type 1 (NF1) is a rare cause of ischemic stroke (IS) in the general population. We report a case of a young patient with NF1 in whom IS was caused by fibromuscular dysplasia. An angiographic study demonstrated occlusion in the right internal carotid artery (ICA), just after its origin, and the left ICA, just before the intracranial portion, and brain magnetic resonance imaging showed the limits of an area of brain infarction in the right frontoparietal region. Despite these concomitant neuroimaging findings, this association is rare, and it is difficult to establish the contribution to the outcome made by each of these diseases, which treatment is the best to implement, or what prognosis is.

Resumo A neurofibromatose tipo 1 (NF1) é uma causa rara de acidente vascular cerebral isquêmico (AVCi) na população geral. Neste estudo, relatamos o caso de um paciente jovem com AVCi, com diagnóstico de NF1 associada a displasia fibromuscular. O estudo angiográfico demonstrou oclusão da carótida interna direita, logo após sua origem, e esquerda, antes da porção intracraniana. A ressonância magnética do encéfalo mostrou delimitação de um infarto na região frontoparietal direita. Apesar desses achados concomitantes na neuroimagem, essa associação é rara, sendo difícil de estabelecer a contribuição de cada uma dessas doenças no desfecho, tampouco qual o melhor tratamento a ser implementado e qual o prognóstico.

Abstract This study was conducted to test the significance of adding row and column factors in the frequentist and Bayesian models used in the evaluation of a population of Passiflora edulis, as well as selecting promising genotypes to form the next generation. The following parameters were evaluated: number of fruits, yield, fruit weight, transverse fruit diameter, longitudinal fruit diameter, pulp percentage, skin thickness and total soluble solids. For the Bayesian model, two priors were considered, namely, inverse gamma and a priori distribution with extended parameters. The model with a priori distribution with extended parameters showed lower root mean square error and higher correlation coefficient between observed and predicted values than the inverse gamma model. Furthermore, for a selection intensity of 37%, the mixed and Bayesian models selected practically the same progenies in both experiments. The use of the 5-fold cross-validation technique indicated that both tested models were efficient.

ABSTRACT Objective: Analyze craving in smokers with cardiovascular comorbidities submitted to a nutritional approach. Methods: Two groups were randomized and submitted to clinical intervention (n = 32): Group 1 (G1, n = 15): ingested 40 g of chocolate containing 70% cocoa/day and behavioral intervention for smoking cessation for one month; Group 2 (G2, n = 17): control group, only behavioral intervention. Questionnaire of Smoking Urges-Brief (QSU-Brief) - Brazil version measured total craving and its factors. Anthropometric measurements verified the nutritional interference of the procedure and the serum assessment verified the interference of inflammatory processes related to smoking. The study was registered on the Brazilian Registry of Clinical Trials (ReBEC): RBR-83jr3. Results: After one month, compared to the initial evaluation, the G1 reduced the craving evaluated by the QSU-Brief and its Factors 1 and 2. Total QSU-Brief: 44.27 ± 15.82 x 27.00 ± 18.03 (p = 0.008); Factor 1: 21.90 ± 7.70 x 12.90 ± 8.87 (p = 0.006); Factor 2: 11.90 ± 6.30 x 7.00 ± 6.63 (0.007). G2 showed a reduction in total QSU-Brief and Factor 1, but not in Factor 2. QSU-Brief total 28.17 ± 17.24 x 19.52 ± 9.50 (p = 0.049); Factor 1: 14.47 ± 8.74 x 9.23 ± 6.11 (p = 0.046). Serum levels of cortisol, leptin, serotonin, C-Reactive Protein (CRP) and insulin did not show differences (p > 0.05). No anthropometric differences were found. Conclusion: The results demonstrate that daily consumption of chocolate for one month (70%) reduced craving in smokers at the beginning of treatment. Chocolate potentiated the well-known effect of behavioral counseling on Factor 1 (pleasurable drug effects) and also interfered with factor 2 (unpleasant withdrawal effects).

RESUMO Objetivo: Analisar o craving em fumantes com comorbidades cardiovasculares submetidos a uma abordagem nutricional. Métodos: Intervenção clínica (n = 32) com dois grupos randomizados: Grupo 1 (G1, n = 15): recebendo 40 g de chocolate contendo 70% de cacau/dia e intervenção comportamental para cessação do tabagismo por um mês; Grupo 2 (G2, n = 17): grupo controle, recebendo apenas intervenção comportamental pelo mesmo período. O Questionnaire of Smoking Urges-Brief (QSU-Brief) – versão Brasil foi utilizado para avaliar o craving. As medidas antropométricas verificaram a interferência nutricional do procedimento e a avaliação sérica, a interferência de processos inflamatórios relacionados ao tabagismo. O estudo foi registrado no Registro Brasileiro de Ensaios Clínicos (ReBEC), RBR-83jr3. Resultados: Um mês depois, comparado à avaliação inicial, o G1 reduziu o craving total e seus fatores (1 e 2). QSU-Brief total: 44,27 ± 15,82 x 27,00 ± 18,03 (p = 0,008); Fator 1: 21,90 ± 7,70 x 12,90 ± 8,87 (p = 0,006); Fator 2: 11,90 ± 6,30 x 7,00 ± 6,63 (0,007). G2: redução no QSU-Brief total e Fator 1, mas não no Fator 2. QSU-Brief total 28,17 ± 17,24 x 19,52 ± 9,50 (p = 0,049); Fator 1: 14,47 ± 8,74 x 9,23 ± 6,11 (p = 0,046). Níveis séricos de cortisol, leptina, serotonina, proteína C-reativa (PCR) e insulina não apresentaram diferenças (p > 0,05). Não foram encontradas diferenças antropométricas significativas. Conclusão: Os resultados demonstram que o consumo diário de chocolate por um mês (70%) reduziu o craving em fumantes no início do tratamento. O chocolate potencializou o conhecido efeito do aconselhamento comportamental sobre o Fator 1 (efeitos prazerosos da droga) e também interferiu no fator 2 (efeitos desagradáveis da abstinência).

ABSTRACT Objective To evaluate the effects of the Covid-19 pandemic on the profile of emergency eye-related visits and compare the findings with the same period before the pandemic. Methods Cross-sectional study performed during one year at a reference eye hospital. Cases registered at the emergency Municipal Hospital Complex of Santo Andre, Brazil, between March, 2019 and February, 2020 were included in the study as the Pre-pandemic group. Cases registered between March, 2020 and February, 2021 were included as the Pandemic group. Cases were classified according to the International Classification of Diseases ICD-10 and Related Health Problems. Results There was a decrease of 52.1% in the emergency eye care visits during the pandemic period (n=9,198) when compared to the pre-pandemic period (n=19,220), with significant reductions in nonspecific cases (-98.1%), postoperative visits (-67.0%), disorders of the conjunctiva (-54.1%), tear film (-49.4%) and refraction (-85.6%) during the pandemic period. Conditions such as retina disorders (+202.7%), sclera disorders (+76.2%), orbit disorders (+20.2%), glaucoma (+66.6%) and trauma (+19.4%) have shown increased rates, as well as those related to eyelids (+186.9%), cornea (+33.4%), uvea (+40.2%), and herpes (+55.3%). Conclusion A drastic reduction in the number of eye-related emergency visits was observed during the Covid-19 pandemic, outlining a new profile of care, with higher frequency of sight-threatening conditions and lower frequency of contagious and non-specific diagnosis.

RESUMO Objetivo Avaliar os efeitos da pandemia da Covid-19 no perfil dos atendimentos oftalmológicos de emergência e comparar os achados com os do período anterior à pandemia. Métodos Estudo transversal realizado ao longo de 1 ano em um hospital oftalmológico de referência. Casos registrados no Complexo Hospitalar Municipal de Emergências de Santo André (SP, Brasil) entre março de 2019 e fevereiro de 2020 foram incluídos no estudo como Grupo Pré-Pandemia. Os casos registrados entre março de 2020 e fevereiro de 2021 foram incluídos no Grupo Pandemia. Os casos foram classificados de acordo com a Classificação Internacional de Doenças e Problemas Relacionados à Saúde. Resultados Houve redução de 52,1% no número de atendimentos oftalmológicos de emergência durante o período pandêmico (n=9.198) quando comparado ao pré-pandêmico (n=19.220), com reduções significativas em casos inespecíficos (-98,1%), visitas pós-operatórias (-67,0%), distúrbios da conjuntiva (-54,1%), filme lacrimal (-49,4%) e refração (-85,6%) durante o período de pandemia. Condições como distúrbios da retina (+202,7%), distúrbios da esclera (+76,2%), distúrbios da órbita (+20,2%), glaucoma (+66,6%) e trauma (+19,4%) apresentaram taxas aumentadas, bem como aquelas relacionadas a pálpebras (+186,9%), córnea (+33,4%), úvea (+40,2%) e herpes (+55,3%). Conclusão Observou-se drástica redução no número de atendimentos oftalmológicos durante a pandemia da Covid-19, delineando um novo perfil de atendimento, com maior frequência de quadros que levam à baixa de visão e à menor frequência de diagnósticos contagiosos e inespecíficos.

RESUMO Objetivo: o artigo apresenta um framework para a condução de pesquisa interpretativa usando algoritmos de aprendizado profundo que dissolvem os limites entre abordagens qualitativas e quantitativas. O trabalho mostra como a pesquisa pode se beneficiar de uma abordagem integrada que usa ferramentas computacionais para superar limitações tradicionais. Proposta: a maior disponibilidade e diversidade de dados tem aumentado o valor dos algoritmos como ferramentas de pesquisa que podem ser utilizadas pelos cientistas sociais. Além disso, ajustar e usar esses artefatos computacionais pode requerer e se beneficiar de procedimentos interpretativos. Tais circunstâncias viram de cabeça para baixo o tradicional debate sobre pesquisa quantitativa e qualitativa: a estratégia de pesquisa que provavelmente produz a maior quantidade de assertividade e rigor é aquela que requer esforço interpretativo mais vigoroso. Nesses termos, a codificação de palavras por meio de redes neurais pode ajudar os pesquisadores a ler com mais proximidade os dados, antes e depois de interpretá-los. Conclusões: para aproveitar a oportunidade produzida por esses novos algoritmos, pesquisadores poderiam ampliar as concepções existentes e adotar um ponto de vista epistemológico mais participativo e agnóstico. O entrelaçamento de métodos computacionais e interpretativos tem potencial de integrar e viabilizar interpretação e mensuração com rigor analítico nos contextos de abundância de dados que devem caracterizar a pesquisa em ciências sociais nas próximas décadas. Objetivo quantitativas tradicionais Proposta disso qualitativa vigoroso termos interpretálos. interpretálos interpretá los. los interpretá-los Conclusões agnóstico décadas

ABSTRACT Objective: the paper introduces a framework for conducting interpretive research using deep learning algorithms that blur the boundaries between qualitative and quantitative approaches. The work evidences how research might benefit from an integrated approach that uses computational tools to overcome traditional limitations. Proposal: the increased availability and diversity of data raises the utility of algorithms as research tools for social scientists. Furthermore, tuning and using such computational artifacts may benefit from interpretive procedures. Such circumstances turn the traditional debate between quantitative and qualitative research on its head: the research strategy that likely yields the most assertiveness and rigor is the one that may require vigorous hermeneutic effort. Along these lines, neural word embeddings can be instrumental in allowing researchers to read the data closely before and after interpretation. Conclusions: to take advantage of the opportunity generated by these new algorithms, researchers may broaden their previous conceptions and adopt a participative point of view. In the coming decades, the interweaving of computational and interpretive methods has the potential to integrate rigorous social science research. Objective approaches limitations Proposal scientists Furthermore procedures head effort lines interpretation Conclusions view decades