Abstract Introduction Sporotrichosis is a common disease in tropical regions, caused by the fungus Sporothrix schenckii, affecting mainly rural workers and in direct contact with animals. Although treatment by indiscriminate use of oral antifungal drugs gives rise resistant isolates, leading to therapeutic failures and no remission of the disease. To evaluate the effectiveness of red low-power laser photobiomodulation in inactivation of S. schenckii infection induced in rodents. Methods Subcutaneously inoculation (2x103 S. schenckii/ml, 0.2 ml suspension) in the left footpad, in 27 mice divided into: control (n = 6, inoculated, without irradiation): early stage (not inoculated) = 1th biopsy; intermediate (9 weeks of evolution) = 2nd biopsy; final (21 weeks of evolution) = 3th biopsy. Treated (n = 21, inoculated and irradiated): early (13 weeks of evolution, 4 weeks after first irradiation) = 4th biopsy, intermediate (17 weeks of evolution, 8 weeks after first irradiation) = 5th biopsy, final (21 weeks of evolution, 12 weeks after first irradiation) = 6th biopsy. Serial irradiation with biopsies occurred every 30 days during each month, for three months. At the end of testing, the mice were euthanized, and histological analyzes of biopsies were performed. Results Each laser treatment session showed an inactivation of S. schenckii in treated animals compared to controls, with a regression of pseudoepitheliomatous hyperplasia, chronic inflammation, neutrophils, granulomas, giant mononuclear cells and steroid corpuscles. Conclusion The laser photobiomodulation was effective on S. schenckii inactivation, appearing to be an interesting therapeutic option in infections caused by this organism.

Resumo Introdução Sintomas como insônia, fadiga, irritabilidade, esquecimento, dificuldade de concentração e queixas somáticas podem sinalizar a existência dos transtornos mentais comuns (TMC). Rastrear e prevenir a integridade da saúde mental dos trabalhadores se faz necessário atualmente. Assim, objetivou-se investigar a associação dos TMC e as variáveis idade, trabalho em turnos e função desempenhada em funcionários de uma indústria metalúrgica do Vale do Paraíba, interior de São Paulo. Método Utilizou-se a versão brasileira do Self-Reporting Questionnaire (SRQ-20). Foram avaliados 77 funcionários (idades entre 20 e 50 anos, média de 35±6 anos). Resultados O segundo turno obteve maior frequência de afetados, com 72%, e na faixa etária entre 33 e 34 anos, com 22%. Entre as variáveis associadas ao humor depressivo-ansioso, verificou-se que a maioria sentia-se nervosa, tensa ou preocupada. Para os sintomas somáticos, a maior parte relatou dores de cabeça frequentes. Quanto ao decréscimo de energia vital, cansar-se com facilidade foi o componente mais influente. Avaliando os pensamentos depressivos, a maioria perdeu o interesse pelas coisas. Evidenciou-se que os ajudantes (31%) e os empilhadeiristas (40%) eram os mais afetados. Conclusão No presente estudo, o SRQ-20 foi eficaz em avaliar os TMC para rastreamento da saúde mental em âmbito ocupacional.

Abstract Introduction Symptoms such as insomnia, fatigue, irritability, forgetfulness, difficulty concentrating, and somatic complaints may signal the existence of Common Mental Disorders (CMD). Therefore, tracking these disorders with the aim of preserving the integrity of workers' mental health is currently required. The objective of this study was to investigate the association of CMDs with the variables age, shiftwork, and role in employees of a metallurgical industry located at the region of Vale do Paraiba, Sao Paulo state, Brazil. Method The Brazilian version of the Self-Reporting Questionnaire (SRQ-20) was used as analytical tool. Results Seventy-seven workers aged 20-50 years were evaluated. The results show that the second work shift presented a higher frequency of affected workers (72%), with 22% of them aged 33-34 years. With respect to the variables associated with depressive-anxious mood, most workers reported feeling nervous, tense or worried. For somatic symptoms, most workers reported frequent headaches. Regarding vital energy decrease, feeling tired easily was detected as the most influential component. For assessment of depressive thoughts, most workers reported frequent loss of interest. The results also show that general assistants (31%) and forklift operators (40%) are the most affected workers. Conclusion The SRQ-20 was effective in assessing CMDs to track occupational mental health.