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au:LEON, ALEXANDRE

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[SciELO Preprints] - Seroprevalence of IgG and IgM anti-SARS-CoV-2 among voluntary blood donors in Rio de Janeiro, Brazil
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Amorim Filho, Luiz Szwarcwald, Célia Landmann Mateos, Sheila de Oliveira Garcia Leon, Antonio Carlos Monteiro Ponce de Medronho, Roberto de Andrade Veloso, Valdiléa Gonçalves Lopes, Josiane Iole França Porto, Luis Cristovão de Moraes Sobrino Chieppe, Alexandre Werneck, Guilherme Loureiro

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Publication date: 2020-05-09

Abstract: En

Background: In Brazil, mathematical models for deriving estimates and projections of COVID-19 cases have been developed without data on asymptomatic SARS-CoV-2 infection. We estimated the seroprevalence of antibodies to SARS-CoV-2 among blood donors in the State of Rio de Janeiro. Methods: Data were collected on 2,857 blood donors from April 14 to 27, 2020. We report the crude prevalence of antibodies to SARS-CoV-2, the weighted prevalence by the total state population, and adjusted prevalence estimates for test sensitivity and specificity. To establish the correlates of SARS-CoV-2 prevalence, we used logistic regression models. The analysis included period and site of blood collection, sociodemographic characteristics, and place of residence. Results: The proportion of SARS-Cov-2 positive tests without any adjustment was 4.0% (95% CI 3.3-4.7%), and the weighted prevalence was 3.8% (95% CI 3.1-4.5%). Further adjustment by test sensitivity and specificity produced lower estimates, 3.6% (95% CI 2.7-4.4%) and 3.3% (95% CI 2.6-4.1%), respectively. The variable most significantly associated with the crude prevalence was the period of blood collection: the later the period, the higher the prevalence. Regarding socio-demographic characteristics, the younger the blood donors, the higher the prevalence, and the lower the educational level, the higher the odds of a positive SARS-Cov-2 antibody. Similar results were found for the weighted prevalence. Discussion: Although our findings resulted from a convenience sample, they match some basic premises: the increasing trend over time, since the epidemic curve in the state is still on the rise; the higher prevalence among the youngest who are more likely to circulate; and the higher prevalence among the less educated as they have more difficulties in following the social distancing recommendations. Despite the study limitations, it is possible to infer that protective levels of natural herd immunity to SARS-CoV-2 are far from being reached in Rio de Janeiro.

https://doi.org/10.1590/SciELOPreprints.404

Relationship between periodontitis and subclinical risk indicators for chronic non-communicable diseases
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TEIXEIRA, Fernanda Cristina Figueira

; MARIN-LEON, Letícia

; GOMES, Everton Padilha

; PEDRÃO, Alice Moreira Neves

; PEREIRA, Alexandre da Costa

; FRANCISCO, Priscila Maria Stolses Bergamo

Brazilian Oral Research

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2020, Volume 34 elocation e058

Abstract: En | Text: En | PDF: En

Abstract In view of the epidemiological relevance of periodontal disease and chronic noncommunicable diseases, the study aimed to evaluate the relationship between them through subclinical indicators of systemic risk in a population group with healthy habits, including alcohol and tobacco abstinence. A complete periodontal examination of six sites per tooth was performed in a sample of 420 participants from the Advento study (Sao Paulo), submitted to anthropometric and laboratory evaluation. Periodontitis was defined and classified based on the Community Periodontal Index score 3 (periodontal pocket = 4–5 mm) and score 4 (periodontal pocket ≥ 6 mm). The prevalence of mild/moderate and severe periodontitis was 20% and 8.2%, respectively. Both categories of periodontal disease had significantly higher levels of triglycerides, C-reactive protein, calcium score, and calcium percentile, whereas blood glucose after tolerance test was significantly higher among people with severe periodontitis and HDL-c levels were lower (p < 0.05). Young adults with severe periodontitis had significantly higher prevalence of obesity, pre-diabetes, hypertension, and metabolic syndrome. Besides these conditions, the older adults with severe periodontitis had significantly higher prevalence of dyslipidemia and subclinical atherosclerosis. The group with periodontitis had also a higher coronary heart disease risk based on the PROCAM score (p < 0.05). The results indicated associations of periodontitis with several systemic indicators for chronic noncommunicable diseases, and highlighted the need for multiprofessional measures in the whole care of patients.

https://doi.org/10.1590/1807-3107bor-2020.vol34.0058 1212 downloads

Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
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Amorim Filho, Luiz

; Szwarcwald, Célia Landmann

; Mateos, Sheila de Oliveira Garcia

; Leon, Antonio Carlos Monteiro Ponce de

; Medronho, Roberto de Andrade

; Veloso, Valdiléa Gonçalves

; Lopes, Josiane Iole França

; Porto, Luis Cristovão de Moraes Sobrino

; Chieppe, Alexandre

; Werneck, Guilherme Loureiro

Revista de Saúde Pública

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2020, Volume 54 elocation 69

Abstract: En | Text: En | PDF: En

ABSTRACT OBJECTIVE To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in the state of Rio de Janeiro, Brazil. METHODS Data were collected on 2,857 blood donors from April 14 to 27, 2020. This study reports crude prevalence of antibodies to SARS-CoV-2, population weighted prevalence for the state, and prevalence adjusted for test sensitivity and specificity. Logistic regression models were used to establish the correlates of SARS-CoV-2 prevalence. For the analysis, we considered collection period and site, sociodemographic characteristics, and place of residence. RESULTS The proportion of positive tests for SARS-Cov-2, without any adjustment, was 4.0% (95%CI 3.3–4.7%), and the weighted prevalence was 3.8% (95%CI 3.1–4.5%). We found lower estimates after adjusting for test sensitivity and specificity: 3.6% (95%CI 2.7–4.4%) for the non-weighted prevalence, and 3.3% (95%CI 2.6–4.1%) for the weighted prevalence. Collection period was the variable most significantly associated with crude prevalence: the later the period, the higher the prevalence. Regarding sociodemographic characteristics, the younger the blood donor, the higher the prevalence, and the lower the education level, the higher the odds of testing positive for SARS-Cov-2 antibody. We found similar results for weighted prevalence. CONCLUSIONS Our findings comply with some basic premises: the increasing trend over time, as the epidemic curve in the state is still on the rise; and the higher prevalence among both the youngest, for moving around more than older age groups, and the less educated, for encountering more difficulties in following social distancing recommendations. Despite the study limitations, we may infer that Rio de Janeiro is far from reaching the required levels of herd immunity against SARS-CoV-2.

https://doi.org/10.11606/s1518-8787.2020054002643 584 downloads

Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
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Amorim Filho, Luiz

; Szwarcwald, Célia Landmann

; Mateos, Sheila de Oliveira Garcia

; Leon, Antonio Carlos Monteiro Ponce de

; Medronho, Roberto de Andrade

; Veloso, Valdiléa Gonçalves

; Lopes, Josiane Iole França

; Porto, Luis Cristovão de Moraes Sobrino

; Chieppe, Alexandre

; Werneck, Guilherme Loureiro

Revista de Saúde Pública

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2020, Volume 54 elocation 69

Abstract: En | Text: En | PDF: En

https://doi.org/10.11606/s1518-8787.2020054002643

Multiple sclerosis in South America: month of birth in different latitudes does not seem to interfere with the prevalence or progression of the disease
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Fragoso, Yara Dadalti

; Adoni, Tarso

; Almeida, Sandra Maria Garcia de

; Alves-Leon, Soniza Vieira

; Arruda, Walter Oleschko

; Barbagelata-Aguero, Fiorella

; Brooks, Joseph Bruno Bidin

; Carra, Adriana

; Claudino, Rinaldo

; Comini-Frota, Elizabeth Regina

; Correa, Eber Castro

; Damasceno, Alfredo

; Damasceno, Benito Pereira

; Diaz, Ethel Ciampi

; Elliff, David George

; Fiore, Ana Patricia Peres

; Franco, Clelia Maria Ribeiro

; Giacomo, Maria Cristina Brandao

; Gomes, Sidney

; Goncalves, Marcus Vinicius Magno

; Grzesiuk, Anderson Kuntz

; Inojosa, Jose Luiz

; Kaimen-Maciel, Damacio Ramon

; Lin, Katia

; Lopes, Josiane

; Lourenco, Gisele Alexandre

; Martinez, Alejandra Diana

; Melcon, Mario Oscar

; Morales, Nivea de Macedo Oliveira

; Morales, Rogerio Rizo

; Moreira, Marcos

; Moreira, Shirlene Vianna

; Oliveira, Celso Luis da Silva

; Oliveira, Francisco Tomaz Menezes de

; Ribeiro, Joao Batista

; Ribeiro, Sonia Beatriz Felix

; Rodriguez, Claudia Carcamo

; Russo, Liliana

; Safanelli, Juliana

; Shearer, Kirsty Deborah

; Siquineli, Fabio

; Vizcarra-Escobar, Darwin

Arquivos de Neuro-Psiquiatria

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sep 2013, Volume 71 N. 9A Pages 573 - 579

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivo Avaliar se o mês de nascimento em diferentes latitudes da América do Sul pode influenciar a presença ou gravidade da esclerose múltipla (EM) na vida. Método Neurologistas de quatro países da América do Sul trabalhando em unidades de EM coletaram os dados de seus pacientes com referência ao mês de nascimento, gênero, idade e progressão da doença. Resultados A análise dos dados mostrou que, para 1207 pacientes com EM e 1207 controles, não havia diferença significativa no mês de nascimento com relação à prevalência de EM em quatro zonas de latitude (0–10; 11–20; 21–30; e 31–40 graus). Não houve relação entre o mês de nascimento e a gravidade da doença em nenhuma destas zonas. Conclusão Os resultados deste estudo mostram que pacientes com EM nascidos de mães grávidas em diferentes latitudes sul não seguem o padrão dos resultados sazonais encontrados nas latitudes norte.

Objective To assess whether the month of birth in different latitudes of South America might influence the presence or severity of multiple sclerosis (MS) later in life. Methods Neurologists in four South American countries working at MS units collected data on their patients' month of birth, gender, age, and disease progression. Results Analysis of data from 1207 MS patients and 1207 control subjects did not show any significant variation in the month of birth regarding the prevalence of MS in four latitude bands (0–10; 11–20; 21–30; and 31–40 degrees). There was no relationship between the month of birth and the severity of disease in each latitude band. Conclusion The results from this study show that MS patients born to mothers who were pregnant at different Southern latitudes do not follow the seasonal pattern observed at high Northern latitudes.

https://doi.org/10.1590/0004-282X20130098 4911 downloads Cited 2 times in SciELO

Male accessory gland substances from Aedes albopictus affect the locomotor activity of Aedes aegypti females
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Lima-Camara, Tamara Nunes

; Codeco, Claudia Torres

; Honorio, Nildimar Alves

; Bruno, Rafaela Vieira

; Peixoto, Alexandre Afranio

; Lounibos, Leon Philip

Memórias do Instituto Oswaldo Cruz

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2013, Volume 108 Suppl. 1 Pages 18 - 25

Abstract: En | Text: En | PDF: En

Dengue is one of the world’s most important mosquito-borne diseases and is usually transmitted by one of two vector species: Aedes aegypti or Aedes albopictus . These two diurnal mosquitoes are frequently found coexisting in similar habitats, enabling interactions between adults, such as cross-mating. The objective of this study was to assess cross-mating between Ae. aegypti females and Ae. albopictus males under artificial conditions and evaluate the locomotor activity of Ae. aegypti virgin females injected with male accessory gland (MAG) homogenates to infer the physiological and behavioural responses to interspecific mating. After seven days of exposure, 3.3-16% of Ae. aegypti females mated with Ae. albopictus males. Virgin Ae. aegypti females injected with conspecific and heterospecific MAGs showed a general decrease in locomotor activity compared to controls and were refractory to mating with conspecific males. The reduction in diurnal locomotor activity induced by injections of conspecific or heterospecific MAGs is consistent with regulation of female reproductive activities by male substances, which are capable of sterilising female Ae. aegypti through satyrisation by Ae. albopictus .

https://doi.org/10.1590/0074-0276130381 3200 downloads Cited 2 times in SciELO

Implante percutâneo de bioprótese valvular aórtica: conciliando os valores clínicos e econômicos de um tratamento estabelecido
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Siqueira, Dimytri Alexandre

; Abizaid, Alexandre A. C.

; Kodali, Susheel

; Leon, Martin B.

Revista Brasileira de Cardiologia Invasiva

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2013, Volume 21 N. 3 Pages 207 - 210

Abstract: Pt | Text: Pt | PDF: Pt

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Duração da suplementação de ractopamina em dietas para leitoas em terminação mantidas sob alta temperatura ambiente
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Silva, Elizangela Alves da

; Kiefer, Charles

; Moura, Mariana Souza de

; Bünzen, Silvano

; Santos, Alexandre Pereira dos

; Silva, Camilla Mendonça

; Nantes, Clariana Leon

Ciência Rural

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feb 2011, Volume 41 N. 2 Pages 337 - 342

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este estudo foi realizado com o objetivo de avaliar a duração da suplementação de ractopamina na dieta de leitoas em terminação, mantidas sob alta temperatura ambiente. Foram utilizadas 48 leitoas com peso inicial de 70,4±2,6kg, distribuídas no delineamento de blocos ao acaso, com seis tratamentos (suplementação de ractopamina por 0, 7, 14, 21, 28 e 35 dias pré-abate) e quatro repetições, sendo a unidade experimental constituída por dois animais. O peso final e o consumo de ração diário não foram influenciados (P>0,05) pelos tratamentos. O ganho de peso aumentou e a conversão alimentar reduziu linearmente (P<0,05) com o aumento do tempo de suplementação de ractopamina na dieta. As características quantitativas de carcaça (peso e rendimento de carcaça quente, espessura de toucinho, percentual de carne magra, profundidade de músculo e área de olho-de-lombo) não foram influenciadas (P>0,05) pela duração da suplementação de ractopamina na dieta. O peso dos pulmões, coração, fígado, rins e baço também não foi modificado (P>0,05) pelos tratamentos. Concluiu-se que a inclusão de 20ppm de ractopamina na dieta de leitoas em terminação, mantidas sob alta temperatura ambiente, durante 28 dias, maximiza a resposta de ganho de peso diário e, durante 35 dias, maximiza a resposta para conversão alimentar. Contudo, a inclusão do aditivo não altera as características quantitativas de carcaça e não afeta o desenvolvimento das vísceras.

The study was conducted to evaluate the duration of the supplementation of ractopamine in the diet of finishing gilts maintained under high temperature environment. Forty eight females, with initial weight of 70.4±2.6kg were used. The pigs were distributed in randomized blocks design of six treatments (supplementation of ractopamine for 0, 7, 14, 21, 28 and 35 days pre-slaughter) and four replications, each experimental unit consisted of two animals. The final weight and daily feed intake were not affected (P>0.05) by treatments. The weight gain increased and the feed conversion decreased linearly (P<0.05) according to the increased length of supplementation of ractopamine in the diet. The quantitative characteristics of carcass (weight and hot carcass yield, backfat thickness, percentage of lean meat, depth of muscle and loin eye area) was not influenced (P>0.05) by duration of supplementation of ractopamine in the diet. The weights of the lungs, heart, liver, kidneys and spleen were not modified (P>0.05) by treatments. It was concluded that inclusion of 20ppm of ractopamine in the diet of finishing gilts maintained under high temperature environment during 28 days maximizes the response of daily gain and during 35 days maximizes the response to feed conversion. However, the inclusion of the additive does not alter the quantitative characteristics of carcass and does not affect the development of the viscera.

1728 downloads

Atypical mole syndrome and dysplastic nevi: identification of populations at risk for developing melanoma - review article
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Silva, Juliana Hypólito

; de Sá, Bianca Costa Soares

; Ávila, Alexandre Leon Ribeiro de

; Landman, Gilles

; Duprat Neto, João Pedreira

Clinics

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2011, Volume 66 N. 3 Pages 493 - 499

Abstract: En | Text: En | PDF: En

Atypical Mole Syndrome is the most important phenotypic risk factor for developing cutaneous melanoma, a malignancy that accounts for about 80% of deaths from skin cancer. Because the diagnosis of melanoma at an early stage is of great prognostic relevance, the identification of Atypical Mole Syndrome carriers is essential, as well as the creation of recommended preventative measures that must be taken by these patients.

https://doi.org/10.1590/S1807-59322011000300023 17223 downloads Cited 1 time in SciELO

10.

Nevo displásico (nevo atípico)
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Rezze, Gisele Gargantini

; Leon, Alexandre

; Duprat, João

Anais Brasileiros de Dermatologia

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dec 2010, Volume 85 N. 6 Pages 863 - 871

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O nevo atípico (displásico) é considerado um fator importante associado com o risco aumentado de desenvolvimento do melanoma cutâneo. Acredita-se que nevos atípicos sejam lesões precursoras do melanoma cutâneo. Podem estar presentes em pacientes com múltiplos nevos melanocíticos (síndrome do nevo atípico) ou isolados e em poucas quantidades em um contexto não familial. Aparecem, geralmente, na puberdade e prevalecem em indivíduos jovens. Têm predileção por áreas expostas ao sol, especialmente, o tronco. O grande desafio em relação ao nevo atípico reside na controvérsia em se definir sua nomenclatura, diagnóstico clínico, critérios dermatoscópicos, diagnóstico histopatológico e aspectos moleculares. Esta revisão tem por objetivo trazer o conhecimento, facilitar o entendimento e responder às questões duvidosas concernentes ao nevo atípico.

Atypical nevum (dysplastic) is considered an important factor associated with increased risk of developing cutaneous melanoma. It is believed that atypical nevi are precursor lesions of cutaneous melanoma. They may be present in patients with multiple melanocytic nevi (atypical nevus syndrome) or isolated and in small numbers in a non-familial context. The disease usually begins at puberty and predominates in young people. It has a predilection for sun-exposed areas, especially the trunk. The major challenge in relation to atypical nevi lies in the controversy of defining its nomenclature, clinical diagnosis, dermoscopic criteria, histopathological diagnosis and molecular aspects. This review aims at bringing knowledge, facilitating comprehension and clarifying doubts about atypical nevus.

75841 downloads Cited 1 time in SciELO

11.

Eficácia de vermífugos à base de avermectinas e milbemicinas utilizados há cinco anos em uma criação de eqüinos
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Nogueira, Carlos Eduardo Wayne

; Lima, Alzira Pacheco de

; Ruas, Jerônimo

; Jardim, Alexandre de Leon

Ciência Rural

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aug 2002, Volume 32 N. 4 Pages 703 - 705

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Avaliou-se a eficácia do controle parasitário com anti-helmínticos (AH) de largo espectro usados há mais de cinco anos, em um plantel eqüino da raça puro-sangue inglês, sob manejo semi-intensivo. Os animais foram tratados com Ivermectin (Eqvalan®) e Moxidectin (Equest®), por via oral. Durante o estudo, o número de ovos por grama de fezes (opg) manteve-se zero na maioria dos animais.

The efficacy of parasite control with broad spectrum anthelmintics, used for over five years on a Thoroughbred herd was evaluated. The animals were kept on semi-intensive pasture regimen. During this study the horses received Ivermectin (Eqvalan®) and Moxidectin (Equest®); both treatments were given orally. The epg number was zero for most animals troughout the trial.

3895 downloads Cited 1 time in SciELO

12.

A Pós-Graduação da Faculdade de Medicina da UFMG: Avaliação do Programa Teórico pelos Egressos
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Viana, Maria Regina de Almeida

; Lamounier, Joel Alves

; Rios, Adriana Martins

; Ávila, Alexandre Leon Ribeiro de

Revista Brasileira de Educação Médica

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apr 2001, Volume 25 N. 1 Pages 62 - 70

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Esta pesquisa foi delineada para buscar informações complementares ao processo de avaliação dos cursos de pós-graduação da Faculdade de Medicina da Universidade de Minas Gerais. Questionários foram elaborados e encaminhados aos 399 egressos do período 1979-95. Um dos objetivos foi avaliar as disciplinas consideradas básicas para a formação pedagógica e de instrumentação em metodologia de pesquisa: Didática Médica, Epidemiologia Humana, Bioestatística, Metodologia Científica e Normalização Bibliográfica. A população que responderam os questionários foi de 260 (65,8%). Cerca de 60% dos egressos avaliaram as disciplinas com o conteúdo “adequado”, carga horária “suficiente”, didática entre “ótima e boa”, recursos audiovisuais entre “excelentes e satisfatórios” e aproveitamento “suficiente”. Os dados remetam a uma reavaliação das disciplinas.

Abstract: This research aimed at gathering supplementary information for the evaluation process focusing on graduate courses at the School of Medicine of the federal University in Minas Gerais. Questionnaires were prepared and submitted to the 399 alumni from the period 1979-95. One of the objectives was to evaluate what are considered basic courses for training in teaching and research methodology: Medical Teaching, Human Epidelilogy, Biostatistics, Scientific Methodology, and Bibliographical Standarzation. A total of 260 alumni (65.8%) answered the questionnaire, 60% of whom evaluate the courses as having “adequate” content, “sufficient” course hours, didactics ranging from “fine” to “good”, audiovisual resources ranging from “excellent” to “satisfactory” and “sufficient” yield. The data suggest the need for a review of the courses.

https://doi.org/10.1590/1981-5271v25.1-009 42 downloads

13.

Aplicação clínica do ultra-som intracoronário
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Abizaid, Alexandre

; Mintz, Gary S.

; Abizaid, Andrea S.

; Satler, Lowell F.

; Popma, Jeffrey J.

; Pichard, Augusto D.

; Mehran, Roxana

; Kent, Kenneth M.

; Leon, Martin B.

Arquivos Brasileiros de Cardiologia

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oct 1997, Volume 69 N. 4 Pages 263 - 265

Abstract: Pt | Text: Pt | PDF: Pt

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Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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