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au:MENESES, ANTONIO CARLOS OLIVEIRA DE

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EPIDEMIOLOGY OF TRAUMATIC FRACTURES OF THE SPINE IN MARIO COVAS HOSPITAL BETWEEN 2015 AND 2020
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Franco, Cássio Bousada

; Cruz, Pedro Henrique Swinerd Coelho da

; Moreno, Caio Cesar Lucchese

; Meneses, Igor Oliveira

; Santos, Lara Guercio dos

; Fontoura Junior, Antonio Carlos

; Brandão, Thiago Kolachinski

; Rodríguez, Luciano Miller Reis

; Yonezaki, Adriano Masayuki

Acta Ortopédica Brasileira

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2023, Volume 31 N. spe3 elocation e267571

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objectives: Analyze the epidemiological profile of patients with traumatic spinal fractures treated at Mário Covas State Hospital between 2015 and 2020. Methodology: This is an epidemiological, descriptive, retrospective, quantitative, comparative, medical records review-type study. Data collection was carried out between May and June 2022 at the Mário Covas State Hospital, the following characteristics being evaluated: age, sex, lesion topography, trauma mechanism, origin and treatment. Results: Data from 252 patients with traumatic spinal fractures were analyzed. The mean age of patients was 48.7 years, 74.7% were male. The mechanism of trauma from falls from a height and the topography of the lumbar vertebrae have a highly significant trend. The most affected vertebrae are lumbar L1, thoracic T12 and cervical C6. The crossing of the age group with the male sex is higher than expected in those over 60 years of age. The crossing of the age group with the trauma mechanism is higher than expected, between 20 and 39 years. Conclusion: There are few published works on the epidemiology of traumatic fractures of the spine, which points to the need for further studies on the subject. Level of Evidence III; Retrospective comparative study.

RESUMO Objetivos: Analisar o perfil epidemiológico dos pacientes com fratura traumática de coluna vertebral atendidos no Hospital Estadual Mário Covas entre os anos de 2015 e 2020. Metodologia: Trata-se de um estudo epidemiológico, descritivo, retrospectivo, quantitativo, comparativo, do tipo revisão de prontuário médico. A coleta de dados foi realizada entre maio e junho de 2022 no Hospital Estadual Mário Covas, sendo avaliadas as características: idade, sexo, topografia da lesão, mecanismo de trauma, procedência e tratamento. Resultados: Foram analisados dados de 252 pacientes com fratura traumática da coluna vertebral. A média da idade dos pacientes foi de 48,7 anos, 74,7% eram do sexo masculino. O mecanismo de trauma tipo queda de altura e a topografia das vértebras lombares têm tendência altamente significativa. As vértebras mais afetadas são lombar L1, torácica T12 e cervical C6. O cruzamento da faixa etária com sexo masculino está acima do esperado nos maiores de 60 anos. O cruzamento da faixa etária com mecanismo do trauma está acima do esperado, entre 20 a 39 anos. Conclusão: São poucos os trabalhos publicados a respeito da epidemiologia das fraturas traumáticas de coluna vertebral, o que aponta para a necessidade de novos estudos acerca da temática. Nível de evidência III; Estudo retrospectivo comparativo.

https://doi.org/10.1590/1413-785220233103e267571

Megakaryocytes in pulmonary circulation: an “old” knowledge with new implications
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de Oliveira, Leonardo Rodrigues

; Meneses, Antônio Carlos de Oliveira

Hematology, Transfusion and Cell Therapy

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apr 2022, Volume 44 N. 2 Pages 303 - 304

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.htct.2021.02.012

Splenic hamartoma associated with visceral leishmaniasis mimicking aggressive lymphoma
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Oliveira, Leonardo Rodrigues de

; Borges, Carla Oranges

; Meneses, Antônio Carlos de Oliveira

Hematology, Transfusion and Cell Therapy

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oct 2020, Volume 42 N. 4 Pages 390 - 393

Abstract: Es | Text: Es | PDF: Es

https://doi.org/10.1016/j.htct.2019.08.002 169 downloads

Agreement between diagnostic imaging methods for the evaluation of lymphadenopathies in HIV-infected/AIDS patients
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Silva, Francisco Carlos da

; Nascentes, Gabriel Antonio

; Meneses, Antonio Carlos Oliveira

; Correia Filho, Dalmo

Radiologia Brasileira

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feb 2019, Volume 52 N. 1 Pages 7 - 11

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Avaliar a porcentagem de concordância entre métodos de diagnóstico por imagem na avaliação de linfonodomegalias em pacientes HIV(+)/AIDS. Materiais e Métodos: Foi realizado estudo aberto, comparativo e prospectivo dos métodos de diagnóstico por imagem na avaliação de linfonodomegalias. Foram avaliados 30 pacientes (19 homens e 11 mulheres). Todos foram submetidos a ultrassonografia e tomografia computadorizada (TC) e 20 também foram submetidos a ressonância magnética (RM). Foi determinado o grau de concordância entre dois examinadores usando-se métodos de diagnóstico por imagem. Resultados: A TC obteve o maior grau de concordância, com taxa de 28/30 (93,3%) e coeficiente kappa de 0,85. Quando comparado o grau de concordância para linfonodomegalias entre dois examinadores e entre TC e ultrassonografia, o examinador 1 teve taxa de 24/30 (80,0%) e kappa de 0,49, e o examinador 2 teve taxa de 21/30 (70,0%) e kappa de 0,31. Entre RM e TC, o examinador 1 teve taxa de 10/20 (50,0%) e kappa de -0,18, e o examinador 2 teve taxa de 17/20 (85,0%) e kappa de 0,69. Entre RM e ultrassonografia, o examinador 1 teve taxa de 14/20 (70,0%) e kappa de 0,20, e o examinador 2 teve taxa de 15/20 (75,0%) e kappa de 0,38. Conclusão: Este estudo indica que a concordância entre métodos depende fortemente da forma como a pesquisa é conduzida e não da capacidade do examinador.

Abstract Objective: To assess the percent agreement between diagnostic imaging modalities for the evaluation of lymphadenopathies in HIV-infected/AIDS patients. Materials and Methods: This was an open, comparative, prospective study of diagnostic imaging methods for lymphadenopathy evaluation. We evaluated 30 patients (19 men and 11 women). All underwent ultrasound and computed tomography (CT). Twenty of the patients also underwent magnetic resonance imaging (MRI). We determined the percent agreement between two examiners using the various imaging methods to evaluate lymphadenopathies. Results: CT had the highest percent agreement, at 93.3%, with a kappa coefficient of 0.85, corresponding to 28 of the 30 examinations. When we compared the percent agreement between the two examiners and between CT and ultrasound, examiner 1 had an observed rate of 80.0%, with a kappa of 0.49, corresponding to 24 of the 30 examinations, whereas examiner 2 had a rate of 70.0%, with a kappa of 0.31, corresponding to 21 of the 30 examinations. Between MRI and CT, the percent agreement for examiner 1 was 50.0%, with a kappa of −0.18, corresponding to 10 of the 20 examinations, whereas that for examiner 2 was 85.0%, with a kappa of 0.69, corresponding to 17 of the 20 examinations. For MRI and ultrasound, examiner 1 had a percent agreement of 70.0%, with a kappa of 0.20, corresponding to 14 of the 20 examinations, and examiner 2 had a percent agreement of 75.0%, with a kappa of 0.38, corresponding to 15 of the 20 examinations. Conclusion: This study indicates that intermethod agreement is highly dependent on the way in which the research is conducted, rather than on the level of experience of the examiner.

https://doi.org/10.1590/0100-3984.2017.0176 625 downloads

Expansion and Phenotypic Changes of Mouse Bone Marrow Mesenchymal Cells Cultured with FGF-2 and Facial Nerve-Conditioned Medium
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Lucena, Eudes Euler de Souza

; de-Morais, Hécio Henrique Araújo

; Araújo, Dayane Pessoa de

; Cavalcanti, José Rodolfo Lopes de Paiva

; Azevedo, Eduardo Pereira de

; Queiroz, Dinalva Brito de

; Botelho, Marco Antônio

; Rêgo, Amália Cinthia Meneses do

; Filho, Irami Araújo

; Barboza, Carlos Augusto Galvão

; Nascimento Júnior, Expedito Silva do

; Costa, Miriam Stela Maris de Oliveira

; Cavalcante, Jeferson de Sousa

; Guzen, Fausto Pierdoná

International Journal of Morphology

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sep 2018, Volume 36 N. 3 Pages 1049 - 1056

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

SUMMARY: Mesenchymal cells (MCs) exhibit great regenerative potential due to their intrinsic properties and ability to restore tissue function, either directly through transdifferentiation or indirectly through paracrine effects. This study aimed to evaluate morphometric and phenotypic changes in MCs grown with facial nerve-conditioned medium in the presence or absence of fibroblast growth factor 2 (FGF-2). For quantitative phenotypic analysis, the expression of GFAP, OX-42, MAP-2, β-tubulin III, NeuN, and NF-200 was analyzed by immunocytochemistry. Cells cultured with facial nerve-conditioned medium in the presence of FGF-2 expressed GFAP, OX-42, MAP-2, β-tubulin III, NeuN, and NF-200. On average, the area and perimeter of GFAP-positive cells were higher in the group cultured with facial nerve-conditioned medium compared to the group cultured with conditioned medium and FGF-2 (p=0.0001). This study demonstrated the plasticity of MCs for neuronal and glial lineages and opens up new research perspectives in cell therapy and trans.differentiation.

RESUMEN: Las células mesenquimales (CM) exhiben un gran potencial regenerativo debido a sus propiedades intrínsecas y la capacidad de restaurar la función del tejido, ya sea directamente, a través de la transdiferenciación, o indirectamente, a través de efectos parácrinos. Este estudio tuvo como objetivo evaluar los cambios morfométricos y fenotípicos en CM cultivadas con medio condicionado por nervio facial en presencia o ausencia de factor de crecimiento de fibroblastos 2 (FGF-2). Para el análisis fenotípico cuantitativo, se analizó la expresión de GFAP, OX-42, MAP-2, β-tubulina III, NeuN y NF-200 mediante inmunocitoquímica. Las células cultivadas con medio condicionado por el nervio facial en presencia de FGF-2 expresaban GFAP, OX-42, MAP-2, β-tubulina III, NeuN y NF-200. En promedio, el área y el perímetro de las células positivas para GFAP fueron mayores en el grupo cultivado con medio condicionado por el nervio facial en comparación con el grupo cultivado con medio acondicionado y FGF-2 (p = 0,0001). Este estudio demostró la plasticidad de CM para linajes neuronales y gliales y abre nuevas perspectivas de investigación en terapia celular y transdiferenciación.

471 downloads

Leiomyoma of the seminal vesicle
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Oliveira, Tatiane Souza

; Stamoulis, Dimitrius Nikolaos Jaconi

; Souza, Luis Ronan Marquez Ferreira de

; Meneses, Antonio Carlos Oliveira

; Mori, Monise Marques

Radiologia Brasileira

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jun 2018, Volume 51 N. 3 Pages 200 - 201

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0100-3984.2016.0159 7289 downloads

Solid variant of aneurysmal bone cist on the distal extremity of the radius in a child
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Ferreira, Adriano Jander

; Leitão, Sebastião de Almeida

; Rocha, Murilo Antônio

; Nascimento, Valdênia das Graças

; Lima, Giovanni Bessa Pereira

; Meneses, Antonio Carlos Oliveira de

Revista Brasileira de Ortopedia

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jun 2016, Volume 51 N. 3 Pages 370 - 373

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A variante sólida do cisto ósseo aneurismático (COA) é considerada lesão rara, ocorre com maior frequência nos pacientes pediátricos e nos ossos da tíbia, fêmur, pelve e úmero. Apresentamos o caso de uma lesão lítica metafisária na extremidade distal do rádio de uma criança em que, ao exame radiográfico feito devido a um trauma de baixa energia, foi aventada a hipótese de fratura em um osso patológico secundária a um cisto ósseo aneurismático. Após a biópsia, a criança foi submetida a ressecção intralesional sem interposição de enxerto e o exame histopatológico foi condizente com a variante sólida do cisto ósseo aneurismático.

ABSTRACT The solid variant of aneurismal bone cysts (ABC) is considered rare. It occurs with greater frequency in pediatric patients and in the tibia, femur, pelvis and humerus. We present a case of a metaphyseal lytic lesion on the distal extremity of the radius in a child whose radiograph was requested after low-energy trauma. The hypothesis of a pathological bone fracture secondary to an aneurysmal bone cyst was suggested. After biopsy, the child underwent intralesional excision without bone grafting and the histopathological findings were compatible with the solid variant of aneurysmal bone cyst.

https://doi.org/10.1016/j.rboe.2016.03.002 3042 downloads

Multiple sclerosis starting before the age of 18 years: the Brazilian experience
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Fragoso, Yara Dadalti

; Ferreira, Maria Lucia Brito

; Morales, Nivea de Macedo Oliveira

; Arruda, Walter Oleschko

; Brooks, Joseph Bruno Bidin

; Carneiro, Denise Sisterolli Diniz

; Carvalho, Margarete de Jesus

; Comini-Frota, Elizabeth Regina

; Correa, Eber Castro

; Damasceno, Carlos Augusto de Albuquerque

; Domingues, Renan Barros

; Finkelsztejn, Alessandro

; Gama, Paulo Diniz da

; Gomes, Sidney

; Goncalves, Marcus Vinicius Magno

; Grzesiuk, Anderson Kuntz

; Khouri, Jussara Mathias Netto

; Kaimen-Maciel, Damacio Ramon

; Mendes, Maria Fernanda

; Morales, Rogerio de Rizo

; Ribeiro, Sonia Beatriz Felix

; Ribeiro, Taysa Alexandrino Gonsalves Jube

; Albuquerque, Livia Brito Bezerra de

; Anacleto, Andrea

; Finkelsztejn, Juliana

; Gama, Rodrigo Assad Diniz da

; Lopes, Josiane

; Oliveira, Celso Luis Silva

; Oliveira, Francisco Tomaz Meneses

; Pires, Leopoldo Antonio

; Saldanha, Patricia Correia de Oliveira

; Souza, Adelia Henriques

; Silva, Alex Eduardo da

Arquivos de Neuro-Psiquiatria

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oct 2013, Volume 71 N. 10 Pages 783 - 787

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Esclerose múltipla (EM) com início na infância e adolescência constitui um desafio para o diagnóstico e manejo da doença. A proposta do presente estudo foi avaliar as características da EM de início precoce em pacientes brasileiros. Métodos Coleta de dados retrospectiva de arquivos de unidades especializadas em atendimento da EM. Resultados A partir de 20 unidades de EM de nove estados brasileiros, foram coletados 117 casos de EM com início antes dos 18 anos de idade. Estes pacientes tinham uma média de 10 anos de duração da doença, de maneira geral apresentavam pouca incapacidade , com um surto a cada dois anos e meio. A média de idade no início da doença era 13,7 anos. Conclusão O presente estudo apresenta uma grande série de casos brasileiros de EM pediátrica. Embora alguns pacientes tenham apresentado forma grave de EM, de maneira geral o grupo de pacientes cuja EM iniciou-se na infância ou adolescência apresentou uma forma relativamente leve da doença no Brasil.

Multiple sclerosis (MS) starting in childhood and adolescence poses a challenge for diagnosis and management of the disease. The aim of the present study was to assess the characteristics of early onset MS in Brazilian patients. Methods Retrospective data collection from specialized MS units. Results From 20 MS units in 11 Brazilian states, 117 cases of MS starting before the age of 18 years were collected. These patients had an average of 10 years of disease duration, still typically with low disability and one relapse every 2.5 years. The mean age for disease onset was 13.7 years. Conclusion The present study introduces a large series of Brazilian cases of pediatric MS. Although some patients presented a very severe form of MS, on the whole the group of patients with MS starting in childhood or adolescence presented a relatively mild form of this disease in Brazil.

https://doi.org/10.1590/0004-282X20130122 4255 downloads Cited 1 time in SciELO

Aplastic anemia associated to systemic lupus erythematosus in an AIDS patient: a case report
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Oliveira, Leonardo Rodrigues de

; Ferreira, Thais Camargos

; Neves, Fernando de Freitas

; Meneses, Antonio Carlos de Oliveira

Revista Brasileira de Hematologia e Hemoterapia

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2013, Volume 35 N. 5 Pages 366 - 368

Abstract: En | Text: En | PDF: En

Aplastic anemia is a bone marrow failure syndrome characterized by peripheral cytopenias and hypocellular bone marrow. Although aplastic anemia is idiopathic in most cases, rheumatic diseases such as systemic lupus erythematosus are recognized as causes of aplastic anemia, with their possible etiological mechanisms being T and B lymphocyte dysfunction and pro-inflammatory cytokines and autoantibody production directed against bone marrow components. In the course of the human immunodeficiency virus infection/acquired immunodeficiency syndrome, the identification of autoantibodies and the occurrence of rheumatic events, in addition to the natural course of systemic lupus erythematosus which is modified by immune changes that are characteristic of human immunodeficiency virus infection/acquired immunodeficiency syndrome, make the diagnosis of systemic lupus erythematosus challenging. This study reports the case of a woman with acquired immunodeficiency syndrome treated with a highly active antiretroviral therapy, who had prolonged cytopenias and hypocellular bone marrow consistent with aplastic anemia. The clinical picture, high autoantibodies titers, and sustained remission of the patient's hematological status through immunosuppression supported the diagnosis of systemic lupus erythematosus-associated aplastic anemia. This is the first report of aplastic anemia concurrent with systemic lupus erythematosus and acquired immunodeficiency syndrome, providing additional evidence that immune dysfunction is a key part of the pathophysiological mechanism of aplastic anemia.

https://doi.org/10.5581/1516-8484.20130100 2544 downloads

10.

Myelophthisis as first manifestation of failure of chemotherapy in breast cancer
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Oliveira, Leonardo Rodrigues de

; Ferreira, Thaís Camargos

; Meneses, Antônio Carlos Oliveira de

Revista Brasileira de Hematologia e Hemoterapia

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2012, Volume 34 N. 3 Pages 245 - 245

Abstract: En | Text: En | PDF: En

https://doi.org/10.5581/1516-8484.20120059 1206 downloads

11.

Edison Reis Lopes
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Meneses, Antonio Carlos Oliveira

; Chapadeiro, Edmundo

; Prata, Aluízio

Revista da Sociedade Brasileira de Medicina Tropical

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dec 2010, Volume 43 N. 6 Pages 759 - 759

Abstract: Pt | Text: Pt | PDF: Pt

2997 downloads

12.

Colangite esclerosante secundária em paciente com síndrome da imunodeficiência adquirida tratada com plastia do ducto hepático comum por via laparoscópica
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Crema, Eduardo

; Ribeiro, Lara Beatriz Prata

; Silva, Fabrício Gomes da

; Pastore, Ricardo

; Meneses, Antônio Carlos Oliveira de

; Silva, Alex Augusto

Revista da Sociedade Brasileira de Medicina Tropical

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oct 2005, Volume 38 N. 5 Pages 438 - 441

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Relatamos o caso de um paciente com icterícia obstrutiva cuja causa era colangite esclerosante secundária à síndrome da imunodeficiência adquirida. Na colangiopatia relacionada à síndrome da imunodeficiência adquirida, os pacientes apresentam dor no quadrante superior direito ou epigástrico, febre, diarréia e alterações biliares características. O paciente foi submetido à plastia transversa do ducto hepático comum por via laparoscópica.

We report the case of a patient with obstructive jaundice caused by sclerosing cholangitis secondary to acquired immunodeficiency syndrome. In acquired immunodeficiency syndrome-related cholangiopathy, patients present with right upper quadrant or epigastric pain, fever, diarrhea and characteristic biliary alterations. The patient was submitted to transverse plasty of the common hepatic duct by laparoscopic route.

9861 downloads

13.

Larva migrans within scalp sebaceous gland
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Guimarães, Lucinda Calheiros

; Silva, José Humberto

; Saad, Kaissor

; Lopes, Edison Reis

; Meneses, Antonio Carlos Oliveira

Revista da Sociedade Brasileira de Medicina Tropical

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apr 1999, Volume 32 N. 2 Pages 187 - 189

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Relata-se caso de larva migrans ou dermatite linear serpiginosa no couro cabeludo de adolescente, no qual o ancilostomídeo foi encontrado no interior de glândula sebácea. Destaca-se a possibilidade do helminto sediar-se em locais pouco usuais, das glândulas sebáceas serem via de penetração de larvas na pele e discute-se o provável mecanismo pelo qual o agente implantou-se no anexo cutâneo.

A case of larva migrans or serpiginous linear dermatitis on the scalp of a teenager is reported. An ancylostomid larva was found within a sebaceous gland acinus. The unusual skin site for larva migrans as well as the penetration through the sebaceous gland are highlighted. The probable mechanism by which the parasite reached the skin adnexa is discussed.

15847 downloads Cited 3 times in SciELO

14.

Meningoencefalites toxoplásmica e chagásica em pacientes com infecção pelo vírus da imunodeficiência humana: diagnóstico diferencial anatomopatológico e tomográfico
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Lazo, Javier E.

; Meneses, Antônio Carlos Oliveira

; Rocha, Ademir

; Frenkel, Jack K.

; Marquez, Jaime Olavo

; Chapadeiro, Edmundo

; Reis Lopes, Edison

Revista da Sociedade Brasileira de Medicina Tropical

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apr 1998, Volume 31 N. 2 Pages 163 - 171

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Em 22 pacientes com sorologia positiva para o vírus da imunodeficiência humana, com ou sem síndrome da imunodeficiência adquirida, dos quais 7 com meningoencefalite toxoplásmica e 15 com meningoencefalite chagásica associadas, procuraram-se dados diferenciais, entre as duas encefalopatias, tanto à anatomia patológica quanto à tomografia computadorizada do crânio. Os resultados observados e os dados da literatura nos permitiram concluir que enquanto na meningoencefalite necrosante focal por Toxoplasma gondii o acometimento dos núcleos da base é freqüente, na meningoencefalite necrosante focal causada pelo Trypanosoma cruzi, lesões dessas estruturas parecem não ocorrer ou ser excepcionais. De outro lado, o acometimento da substância branca parece nitidamente maior na meningoencefalite chagásica que na meningoencefalite toxoplásmica, ao passo que o parasitismo e a hemorragia do tecido nervoso, bem como as lesões das bainhas de mielina são mais freqüentes e intensos na meningoencefalite causada pelo Trypanosoma cruzi que naquela por Toxoplasma.

Twenty-two HIV+ patients with encephalitis were studied. Of these, 7 had meningoencephalitis due to Toxoplasma gondii (MT) and 15 due to Trypanosoma cruzi (MC). Pathologic and computerized axial tomography (CAT) changes were compared. We found that focal necrotizing encephalitis due to Toxoplasma involved the cerebral cortex and the basal ganglia, whereas lesions due to Trypanosoma cruzi were centered in the white matter, sometimes extending into the cortex. Hemorrhages, myelin lesions and organisms were more pronounced in chagasic than in toxoplasmic encephalitis. These findings are consistent with the literature reviewed.

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Chagasic meningoencephalitis in the immunodeficient
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JAVIER, LAZO

; MENESES, ANTONIO CARLOS OLIVEIRA

; ROCHA, ADEMIR

; FERREIRA, MARCELO SIMÃO

; MARQUEZ, JAIME OLAVO

; CHAPADEIRO, EDMUNDO

; LOPES, EDILSON REIS

Arquivos de Neuro-Psiquiatria

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mar 1998, Volume 56 N. 1 Pages 93 - 97

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Baseados na experiência pessoal e nos dados da literatura, os autores comparam as alterações anatomopatológicas encefálicas resultantes da reativação da infecção pelo Trypanosoma cruzi, de paciente HIV+, com aquelas observadas e descritas na história natural da doença de Chagas (DC). A meningoencefalite chagásica necrosante focal (MECNF) que somente se desenvolve em tripanosomoticos imunodeficientes, especialmente quando a imunodeficiência é devida ao HIV, tem características peculiares e constitui parâmetro anatomopatológico seguro, de reativação da DC. Esta MECNF apresenta lesões diversas daquelas que podem ser observadas e que são descritas em casos da fase aguda e da forma nervosa crônica da DC.

Based on their own experience and on the literature, the authors compare the brain pathology due to HIV+ associated Trypanosoma cruzi reactived infection to that described for the natural history of the Chagas' disease (CD). The peculiar focal necrotizing chagasic meningoencephalitis (MECNF) which appears only in immunedeficient chagasics, especially when the deficiency is due HIV is a safe criterion for reactivation of CD. MECNF morphologic findings are unlike to those found either for some cases of acute phase CD or for chronic nervous form of CD.

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