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Abstract: The present study aimed to evaluate the applicability and efficiency of the FAI-BLUP index in the genetic selection of maize hybrids, using 84 maize hybrids that were evaluated for cycle, morphology, and yield traits in four environments. Models accounting for homogeneous and heterogeneous residual variances were tested, and variance components were estimated using the residual maximum likelihood. Genotypic values were predicted by best linear unbiased prediction, and factor analysis was applied to group the traits. The FAI-BLUP index was used for the selection of maize hybrids based on ideotype design. Three factors explained more than 70% of genotypic variability, with selective accuracies varying from low (0.46) to high (0.99). Predicted genetic gains were positive for traits related to yield and negative for traits related to cycle and morphology, as is desirable in maize crop.

https://doi.org/10.1590/1984-70332021v21n2a31 46 downloads

Estrategia de pesquisa sistemática y seguimiento prolongado revela alto número de nuevas infecciones tuberculosas en contactos adultos en la Región Metropolitana, Chile
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Balcells, María Elvira

; Carvajal, Camila

; Fernández, Paula

; Ruiz-Tagle, Cinthya

; Pizarro, Alejandra

; García, Patricia

; Peña, Carlos

; Cuevas, Gerardo

; Naves, Rodrigo

Revista médica de Chile

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feb 2020, Volume 148 N. 2 Pages 151 - 159

Abstract: Es | Text: Es | PDF: Es

Background: Contact investigation is cardinal in the control of tuberculosis (TB) since it helps to stop its transmission. In Chile, the National TB Program strategy does not include latent TB infection testing, regular chemoprophylaxis or follow-up in adults. Active TB was found in only 1.2% of contacts at country-level during 2018. Aim: To evaluate the performance of a systematic screening of adult household contacts with targeted chemoprophylaxis and prolonged active follow-up. Material and Methods: Prospective cohort of household contacts in Santiago. Two face-to-face visits (at 0 and 12 weeks) that included QuantiFERON TB-Gold plus tests (QFT), chest radiography (CXR) at 0 and 24 weeks and, periodic text messaging or phone call follow-up for up to 48 weeks were implemented. Contacts with positive QFT were referred for TB chemoprophylaxis. Results: A total of 200 contacts were enrolled, 69% were migrants. At baseline evaluation, 45% had a positive QFT result and 1.6% had co-prevalent active TB. At follow-up, 13% contacts further converted to QFT (+), and 5.1% more were diagnosed with active TB (mean follow-up time 32 weeks). Of these 10 further active TB cases, 6 (60%) had a negative QFT and all (100%) had normal CXR at baseline; while three cases occurred in QFT converters. Conclusions: In this cohort of household contacts, 6.7 % were diagnosed with active TB (more than 2/3 at follow-up) and 13% had a late QFT (+) conversion. Active and prolonged contacts' follow-up are essential to detect new infections and tackle the TB epidemic in Chile.

https://doi.org/10.4067/s0034-98872020000200151 800 downloads

Evaluation of Pharmaceutical Services in Public Hospital Pharmacies of Federal District-Brazil
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Fonseca Lima, Rodrigo

; de Toledo, Maria Inês

; Dourado Silva, Paulo Henrique

; Silva Naves, Janeth de Oliveira

Farmacia Hospitalaria

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jun 2018, Volume 42 N. 3 Pages 108 - 115

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Objective: To evaluate pharmaceutical services in public hospital pharmacies of the Federal District Health Department - Brazil (Secretaria de Saúde do Distrito Federal, SES-DF). Method: A cross-sectional evaluative study involving the 15 public hospitals under the SES-DF management. Hospitals were characterized and classified into four hierarchical strata. The pharmaceutical services related to programming (quantity of medication to order), acquisition, storage, distribution, management, selection, information, pharmacotechnical component, pharmacotherapy follow-up, teaching and research were evaluated using validated indicators. Next, algorithms were applied and the approximation percentages of service compliance were calculated, then correlated to variables that could influence their results through linear regression analysis. Results: Only four hospital pharmacies presented good compliance with the evaluated services, three of them belonging to less complex hospitals. Only the storage and management services presented good performance. The variables that most influenced the performance of the services were managerial aspects related to pharmacists and non pharmacists’ workload per bed, the existence of a program for human resources qualification, planning goals and targets and a manual of norms and procedures, as well as professional qualification and adequacy of the area in which the services were performed (p < 0.01). Conclusions: The evaluated hospital pharmacies had average performance for services compared to the ideal and better performance in logistics activities. Pharmaceutical services require constant evaluation for rational interventions that increase the proportion of executed health care activities and local management capacity to make such actions more effective, efficient, qualified and safe in the context of the SES-DF hospital network.

Resumen Objetivo: Evaluar los servicios farmacéuticos en farmacias públicas de hospitales del Departamento de Salud del Distrito Federal - Brasil (Secretaria de Saúde do Distrito Federal, SES-DF). Método: Estudio transversal evaluativo de los 15 hospitales públicos bajo gestión de la SES-DF. Los hospitales fueron caracterizados y se clasificaron en cuatro estratos jerárquicos. Los servicios de programación, adquisición, almacenamiento, distribución, gestión, selección, información, farmacotécnica, seguimiento farmacoterapéutico, enseñanza y investigación fueron evaluados utilizando indicadores validados. Se aplicaron algoritmos y se calcularon los porcentajes de aproximación del cumplimiento del servicio, que se correlacionaron con variables que podrían influir en los resultados a través de la regresión lineal. Resultados: Solo cuatro farmacias hospitalarias presentaron un buen cumplimiento de los servicios evaluados; tres pertenecientes a hospitales menos complejos. Solo el almacenamiento y la gestión presentaron un buen desempeño. Las variables que más influyeron en el desempeño de los servicios fueron la carga de trabajo de farmacéuticos y no farmacéuticos por cama; la existencia de un programa de cualificación de recursos humanos, objetivos y metas; el manual de normas y procedimientos, y la cualificación profesional y la adecuación del área de ejecución de los servicios (p < 0,01). Conclusiones: Las farmacias hospitalarias evaluadas presentaron un cumplimiento medio de los servicios en comparación con el ideal y el mejor desempeño de las actividades logísticas. Los servicios farmacéuticos requieren una evaluación constante con vistas a intervenciones racionales que amplíen la ejecución de las actividades asistenciales y la capacidad de gestión local con el objetivo de hacer tales acciones más efectivas, eficientes, cualificadas y seguras.

https://doi.org/10.7399/fh.10941 319 downloads

Efeito Calendário e Finanças Comportamentais no Segmento de Fundos Multimercados
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Malaquias, Rodrigo Fernandes

; Mamede, Samuel de Paiva Naves

Revista de Administração Contemporânea

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may 2015, Volume 19 N. spe Pages 98 - 116

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo geral deste trabalho consistiu em analisar a relação entre os dias de segunda-feira com a rentabilidade proporcionada pelos fundos de investimentos multimercados brasileiros. A base final de análise foi composta por 3.337 fundos multimercados, totalizando 3.529.808 observações para dados diários, no período de janeiro/2005 a setembro/2013. Com a utilização da análise de regressão com dados em painel, levando-se em consideração variáveis de controle apontadas pela literatura como relevantes, os principais resultados indicaram que o efeito segunda-feira também ocorre no segmento de fundos de investimento, sendo intensificado por períodos de crises financeiras. Contudo constatou-se que esse efeito não foi uniforme entre todas as subcategorias de fundos multimercados. Os resultados foram persistentes entre fundos cujo prazo de resgate é D+0, bem como foram robustos ao controle pela série de retornos do Ibovespa. A discussão foi ancorada principalmente na Teoria de Finanças Comportamentais, buscando-se assim potenciais explicações para essa anomalia de mercado.

The aim of this paper was to analyze the relationship between Mondays and the profitability provided by Brazilian hedge funds. We used a data basis composed of 3,337 hedge funds, totaling 3,529,808 observations of daily data, during the period from January 2005 until September 2013. To test the hypothesis, we used regression with panel data and we inserted control variables in the model that the literature points out as relevant. The main results showed that the Monday effect also occurs in the hedge funds segment and this effect is intensified in periods of financial crisis. However, we show that the effect is not consistent across all sub-categories of hedge funds. The results were persistent for funds which don't have a redemption period, as well as for the control for the Ibovespa daily returns. The discussion was mainly based on Behavioral Finance Theory in seeking potential explanations for this anomaly.

https://doi.org/10.1590/1982-7849rac20152062 2967 downloads

II Diretriz de Ressonância Magnética e Tomografia Computadorizada Cardiovascular da Sociedade Brasileira de Cardiologia e do Colégio Brasileiro de Radiologia
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Sara, Leonardo

; Szarf, Gilberto

; Tachibana, Adriano

; Shiozaki, Afonso Akio

; Villa, Alexandre Volney

; Oliveira, Amarino Carvalho de

; Albuquerque, Andrei Skromov de

; Rochitte, Carlos Eduardo

; Nomura, César Higa

; Azevedo, Clerio Francisco

; Jasinowodolinski, Dany

; Tassi, Eduardo Marinho

; Medeiros, Fabio de Morais

; Kay, Fernando Uliana

; Junqueira, Flávia Pegado

; Azevedo, Guilherme S. A.

; Monte, Guilherme Urpia

; Pinto, Ibraim Masciarelli Francisco

; Gottlieb, Ilan

; Andrade, Joalbo

; Lima, João A. C.

; Parga Filho, José Rodrigues

; Kelendjian, Juliana

; Fernandes, Juliano Lara

; Iquizli, Leonardo

; Correia, Luis C. L.

; Quaglia, Luiz Augusto

; Gonçalves, Luiz Flavio Galvão

; Ávila, Luiz Francisco

; Zapparoli, Marcello

; Hadlich, Marcelo

; Nacif, Marcelo Souto

; Barbosa, Márcia de Melo

; Minami, Márcio Hiroshi

; Bittencourt, Marcio Sommer

; Siqueira, Maria Helena Albernaz

; Silva, Marly Conceição

; Lopes, Marly Maria Uellendahl

; Marques, Mateus Diniz

; Vieira, Mônica La Rocca

; Coellho Filho, Otávio Rizzi

; Schvartzman, Paulo R.

; Santos, Raul D.

; Cury, Ricardo C.

; Loureiro, Ricardo

; Cury, Roberto Caldeira

; Sasdelli Neto, Roberto

; Macedo, Robson

; Cerci, Rodrigo Julio

; Faria Filho, Rui Alberto de

; Cardoso, Sávio

; Naves, Thiago

; Magalhães, Tiago Augusto

; Senra, Tiago

; Burgos, Ursula Maria Moreira Costa

; Moreira, Valéria de Melo

; Ishikawa, Walther Yoshiharu

Arquivos Brasileiros de Cardiologia

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dec 2014, Volume 103 N. 6 Pages 1 - 86

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.5935/abc.2014S006 67586 downloads

Fungos micorrízicos arbusculares em fitofisionomias do Pantanal da Nhecolândia, Mato Grosso do Sul
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Gomide, Plínio Henrique Oliveira

; Silva, Marx Leandro Naves

; Soares, Cláudio Roberto Fonsêca Sousa

; Cardoso, Evaldo Luis

; Carvalho, Fernanda de

; Leal, Patrícia Lopes

; Marques, Rodrigo Magalhães

; Stürmer, Sidney Luiz

Revista Brasileira de Ciência do Solo

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aug 2014, Volume 38 N. 4 Pages 1114 - 1127

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O bioma Pantanal é reconhecido como uma das maiores extensões úmidas contínua do planeta, com fauna e flora de rara beleza e abundância. Estudos para acessar a diversidade de fungos micorrízicos arbusculares (FMA) nesse ambiente são inexistentes. O objetivo deste trabalho foi avaliar a ocorrência de FMA nas diferentes fitofisionomias do Pantanal da Nhecolândia, Mato Grosso do Sul. Foram coletadas amostras de solo no período seco e chuvoso em um Neossolo Quartzarênico, em fitofisionomias sujeitas a distintos regimes de inundação: livres de inundação - Floresta Semidecídua (FS) e Cerradão (CE); sujeitos à inundação ocasional - Campo limpo, predominando Elyonorus muticus (CLE) e Cerrado (CC); e sujeitos à inundação sazonal - Campo limpo, predominando Andropogon spp. (CLA), borda de baias (BB) e vazante/baixadas (VB). Culturas armadilhas foram estabelecidas com Brachiaria brizantha para recuperar espécies crípticas de FMA. De cada amostra de solo, foram realizadas a caracterização química do solo e extração dos esporos de FMA para determinar abundância, riqueza e identificação das espécies. Um total de 37 espécies de FMA, pertencentes a 10 gêneros e seis famílias foram detectadas nas duas estações de coleta. O número de esporos variou significativamente entre as fitofisionomias, e os maiores valores foram encontrados em CE e CLA. A maior riqueza específica foi detectada em CC (25 espécies) seguida de VB e CE com 22 e 21 espécies, respectivamente. Os resultados deste estudo sugeriram que a diversidade dos FMA está relacionada com a heterogeneidade existente entre as fitofisionomias, e que características químicas do solo têm influência na estruturação das comunidades desses fungos. Considerando que o bioma Pantanal é um dos ecossistemas mais conservado do planeta, o levantamento de ocorrência de FMA realizado neste trabalho forneceu informações importantes para melhor conhecimento da biodiversidade das fitofisionomias do Pantanal da Nhecolândia.

The Pantanal (tropical wetland) biome is recognized as one of the largest continuous areas of natural wetlands, harboring a flora and fauna of rare beauty and abundance. Studies to assess the diversity of arbuscular mycorrhizal fungi (AMF) are nonexistent for this environment. The goal of this study was to evaluate the occurrence of AMF in different vegetation types of the Pantanal of Nhecolândia, Brazil. Soil samples were collected during the dry and wet season in a Neossolo Quartzarênico (Entisol) in vegetation types subject to different flooding regimes: flood-free - semi-deciduous forest (FS) and "Cerradão" (CE); subject to occasional flooding - grassland dominated by Elyonurus muticus (CLE) and "Cerrado" (CC); and subject to seasonal flooding - grasslands dominated by Andropogon spp. (CLA), the edge of bays (BB), and areas exposed at low water/lowlands (VB). Trap crops were established with Brachiaria brizantha to recover cryptic AMF species. Chemical analyses and spore extraction were carried for each soil sample to identify AMF species and determine their abundance and richness. A total of 37 AMF species, belonging to 10 genera and six families, were detected for both seasons. Spore numbers varied significantly among vegetation types, and the highest values were found in CE and CLA. The greatest richness of species was detected in CC (25 species), followed by VB, with 22 species, and CE, with 21 species. This is the first report on AMF diversity from the Pantanal biome. Results of this study suggest that AMF diversity is related to the heterogeneity among vegetation types and that soil chemical characteristics influence the structure of these fungi communities. Considering that the Pantanal is one of the most conserved biomes in the world, the survey of the occurrence of AMF in this study provides important information for better understanding the biodiversity of the phytophysiognomies of this biome.

3684 downloads

Iniciativa Unidade Básica Amiga da Amamentação e sua relação com o aleitamento materno exclusivo
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Alves, Ana Lúcia Naves

; Oliveira, Maria Inês Couto de

; Moraes, José Rodrigo de

Revista de Saúde Pública

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dec 2013, Volume 47 N. 6 Pages 1130 - 1140

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

OBJETIVO : Analisar a prevalência do aleitamento materno exclusivo e sua associação com a assistência pela Iniciativa Unidade Básica Amiga da Amamentação. MÉTODOS : Estudo transversal, com dados da pesquisa sobre práticas alimentares no primeiro ano de vida conduzida nas campanhas de vacinação em Barra Mansa, RJ, em 2003 e 2006. Foram selecionadas as crianças < 6 meses, no total 589 em 2003 e 707 em 2006. Tomou-se por base o inquérito de 2006 para estimar a relação entre ser assistido pela Iniciativa Unidade Básica Amiga da Amamentação e a prática do aleitamento materno exclusivo. Variáveis de exposição que se mostraram associadas (p ≤ 0,20) ao desfecho na análise bivariada foram selecionadas para a análise múltipla. As razões de prevalência ajustadas foram obtidas por modelo de regressão de Poisson com variância robusta, segundo modelo conceitual hierarquizado. O modelo final foi composto por variáveis de exposição que obtiveram p ≤ 0,05. RESULTADOS : A prevalência do aleitamento materno exclusivo aumentou de 30,2% em 2003 para 46,7% em 2006. Baixa escolaridade materna reduziu o aleitamento materno exclusivo em 20,0% (RP = 0,798; IC95% 0,684;0,931), o parto cesariano em 16,0% (RP = 0,838; IC95% 0,719;0,976), o uso de chupeta em 41,0% (RP = 0,589; IC95% 0,495;0,701) e a prevalência de aleitamento materno exclusivo foi 1,0% menor a cada dia de vida da criança (RP = 0,992; IC95% 0,991;0,994) na análise múltipla. O acompanhamento do bebê por unidade credenciada na Iniciativa Unidade Básica Amiga da Amamentação aumentou o desfecho em 19,0% (RP = 1,193; IC95% 1,020;1,395). CONCLUSÕES : A Iniciativa Unidade Básica Amiga da Amamentação contribuiu para a prática do aleitamento materno exclusivo e para orientação de gestantes e mães quando implementada na rede primária de saúde.

OBJECTIVE : To analyze the prevalence of exclusive breastfeeding and the association with the Breastfeeding-Friendly Primary Care Unit Initiative. METHODS : Cross-sectional study, whose data source were research on feeding behaviors in the first year of life conducted in the vaccination campaigns of 2003 and 2006, at the municipality of Barra Mansa, RJ, Southeastern Brazil. For the purposes of this study, infants under six months old, accounting for a total of 589 children in 2003 and 707 children in 2006, were selected. To verify the relationship between being followed-up by Breastfeeding-Friendly Primary Care Unit Initiative units and exclusive breastfeeding practice, only data from the 2006 inquiry was used. Variables that in the bivariate analysis were associated (p-value ≤ 0.20) with the outcome (exclusive breastfeeding practice) were selected for multivariate analysis. Prevalence ratios (PR) of exclusive breastfeeding were obtained by Poisson Regression with robust variance through a hierarchical model. The final model included the variables that reached p-value ≤ 0.05. RESULTS : The prevalence of exclusive breastfeeding increased from 30.2% in 2003 to 46.7% in 2006. Multivariate analysis showed that mother’s low education level reduced exclusive breastfeeding practice by 20.0% (PR = 0.798; 95%CI 0.684;0.931), cesarean delivery by 16.0% (PR = 0.838; 95%CI 0.719;0.976), and pacifier use by 41.0% (PR = 0.589; 95%CI 0.495;0.701). In the multiple analysis, each day of the infant’s life reduced exclusive breastfeeding prevalence by 1.0% (PR = 0.992; 95%CI 0.991;0.994). Being followed-up by Breastfeeding-Friendly Primary Care Initiative units increased exclusive breastfeeding by 19.0% (PR = 1.193; 95%CI 1.020;1.395). CONCLUSIONS : Breastfeeding-Friendly Primary Care Unit Initiative contributed to the practice of exclusive breastfeeding and to the advice for pregnant women and nursing mothers when implemented in the primary health care network.

OBJETIVO : Analizar la prevalencia de la lactancia materna exclusiva y su asociación con la asistencia por la Iniciativa Unidad Básica Amiga de la Lactancia. MÉTODOS : Estudio transversal, con datos de la investigación sobre prácticas alimenticias en el primer año de vida conducida en las campañas de vacunación en Barra Mansa, RJ, Brasil, en 2003 y 2006. Se seleccionaron los niños < 6 meses, en total 589 en 2003 y 707 en 2006. Se consideró como base la investigación de 2006 para estimar la relación entre ser asistido por la Iniciativa Unidad Básica Amiga de la Lactancia y la práctica de la lactancia materna exclusiva. Variables de exposición que se mostraron asociadas (p ≤ 0,20) al resultado en el análisis bivariado y se seleccionaron para el análisis múltiple. Los cocientes de prevalencia ajustados fueron obtenidos por modelo de regresión de Poisson con varianza robusta, según modelo conceptual jerarquizado. El modelo final estuvo compuesto por variables de exposición que obtuvieron p ≤ 0,05. RESULTADOS : La prevalencia de la lactancia materna exclusiva aumentó de 30,2% en 2003 a 46,7% en 2006. La baja escolaridad materna redujo la lactancia materna exclusiva en 20% (RP = 0,798; IC95% 0,684;0,931), el parto por cesárea en 16,0% (RP = 0,838; IC95% 0,719;0,976), el uso de chupón en 41,0% (RP = 0,589; IC95% 0,495;0,701) y la prevalencia de lactancia materna exclusiva fue 1,0% menor a cada día de vida del niño (RP = 0,992; IC95% 0,991;0,994) en el análisis múltiple. El acompañamiento del bebé por unidad autorizada en la Iniciativa Unidad Básica Amiga de la Lactancia aumentó el resultado en 19,0% (RP = 1,193; IC95% 1,020;1,395). CONCLUSIÓN : La Iniciativa Unidad Básica Amiga de la Lactancia contribuyó para la práctica de la lactancia materna exclusiva y su implementación en el conjunto de la red primaria de salud para orientación de gestantes y madres.

https://doi.org/10.1590/S0034-8910.2013047004841 6947 downloads

Iniciativa Unidade Basica Amiga da Amamentacao e sua relacao com o aleitamento materno exclusivo
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Alves, Ana Lucia Naves

; Oliveira, Maria Ines Couto de

; Moraes, Jose Rodrigo de

Revista de Saúde Pública

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dec 2013, Volume 47 N. 6 Pages 1130 - 1140

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/S0034-8910.2013047004841 3868 downloads

10.

Importância das radiografias de seio frontal para a identificação humana
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Silva, Rhonan Ferreira da

; Pinto, Rodrigo Naves

; Ferreira, Geovane Miranda

; Daruge Júnior, Eduardo

Revista Brasileira de Otorrinolaringologia

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oct 2008, Volume 74 N. 5 Pages 798 - 798

Abstract: Pt | Text: Pt | PDF: Pt

6092 downloads

11.

A complexidade de Volpi: notas sobre o diálogo do artista com concretistas e neoconcretistas
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Naves, Rodrigo

Novos estudos CEBRAP

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jul 2008, N. 81 Pages 139 - 155

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Em sentido oposto à crença segundo a qual Volpi seria um artista intuitivo, este artigo sustenta que o artista chegou às soluções de sua obra a partir de uma incorporação peculiar de toda a tradição moderna. O artigo mostra ainda como a experiência de Volpi com as discussões levantadas por concretos e neoconcretos contribuiu para suas novas articulações formais, ainda que com soluções bem distantes daquelas encontradas pelos artistas dos dois grupos.

In the opposite direction of the belief according to which Volpi would be an intuitive artist, this article states that the artist found the solutions of his work after a peculiar assimilation of the modern tradition. The article shows how Volpi's experience with discussions raised by concrete and neoconcrete artists helped shape his formal articulations, even though with solutions quite different from those of the artists of both groups.

10432 downloads Cited 2 times in SciELO

12.

Where Alfredo Volpi Starts to get complex: the painter's: dialogue with both concretistas and neoconcretista
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Naves, Rodrigo

; Rodgers, David Allan

Novos Estudos - CEBRAP

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2008, Volume 4 N. se

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

5093 downloads

13.

Solução salina hipertônica para prevenção de insuficiência renal em pacientes com insuficiência cardíaca descompensada e hiponatremia
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Issa, Victor Sarli

; Bacal, Fernando

; Mangini, Sandrigo

; Carneiro, Rodrigo Moreno Dias

; Azevedo, Cristiano Humberto Naves de Freitas

; Chizzola, Paulo Roberto

; Ferreira, Silvia Moreira Ayub

; Bocchi, Edimar Alcides

Arquivos Brasileiros de Cardiologia

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oct 2007, Volume 89 N. 4 Pages 251 - 255

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

FUNDAMENTO: Hiponatremia e fenômenos congestivos indicam mau prognóstico na insuficiência cardíaca descompensada. A ocorrência de insuficiência renal está associada a aumento do risco de morte. OBJETIVO: Avaliar a segurança e a eficácia da solução hipertônica em pacientes com insuficiência cardíaca descompensada para prevenção de insuficiência renal. MÉTODOS: Participaram do estudo pacientes com insuficiência cardíaca descompensada, congestão e hiponatremia. Além do tratamento padrão, os pacientes receberam solução salina hipertônica, e foram submetidos a avaliação tanto clínica como laboratorial. RESULTADOS: Foram incluídos 9 pacientes. A média das idades dos pacientes foi de 55 + 14,2 anos, sendo 5 (55,5%) do sexo masculino e 4 (44,5%), do feminino. Todos apresentavam classe funcional III-IV da New York Heart Association (NYHA), e 5 (55,5%) recebiam dobutamina. Todos apresentaram creatinina inicial acima de 1,4 mg/dl. A tonicidade média da solução foi de 4,39% + 0,018% (2,5% a 7,5%) e a duração do tratamento foi de 4,9 dias + 4,1 dias (1 dia a 15 dias). Não houve efeitos adversos graves; em nenhum caso houve piora clínica ou distúrbios neurológicos; hipocalemia ocorreu em 4 (44,5%) casos. A comparação das variáveis pré- e pós-tratamento demonstrou queda da uréia (105 mg/dl + 74,8 mg/dl vs. 88 mg/dl + 79,4 mg/dl; p = 0,03) e aumento do volume urinário (1.183 ml/dia vs. 1.778 ml/dia; p = 0,03); houve tendência a redução da creatinina (2,0 mg/dl + 0,8 mg/dl vs. 1,7 mg/dl + 1,0 mg/dl; p = 0,08). Apesar da elevação do valor do sódio (131 mEq/l + 2,8 mEq/l vs. 134 mEq/l + 4,9 mEq/l) e da redução do peso (69,5 kg + 18,6 kg vs. 68,2 kg + 17,1 kg), não houve diferença estatisticamente significante. CONCLUSÃO: O uso de solução salina hipertônica em pacientes com insuficiência cardíaca descompensada pode ser método terapêutico seguro e potencialmente relacionado a melhora clínica e de prevenção da insuficiência renal.

BACKGROUND: Hyponatremia and congestive phenomena indicate a bad prognosis in decompensated heart failure. The occurrence of renal failure is associated to an increased death risk. OBJECTIVE: To evaluate the safety and efficacy of the hypertonic saline solution in patients with decompensated heart failure for renal failure prevention. METHODS: Patients with decompensated heart failure, congestion and hyponatremia participated in the study. In addition to the standard treatment, the patients received hypertonic saline solution and were submitted to clinical as well as laboratory assessment. RESULTS: Nine patients were enrolled in the study. Mean age was 55 + 14.2 years, being 5 male (55.5%) and 4 (44.5%) female patients. All of them presented functional class III-IV of the New York Heart Association (NYHA), and 5 (55.5%) received dobutamine. All of them presented initial creatinine > 1.4 mg/dl. The mean tonicity of the solution was 4.39% + 0.018% (2.5% to 7.5%) and the duration of treatment was 4.9 days + 4.1 days (1-15 days). There were no severe adverse effects; none of the patients presented clinical worsening or neurologic disorders; hypokalemia occurred in 4 cases (44.5%). The comparison of the variables before and after treatment showed a decrease in urea (105 mg/dl + 74.8 mg/dl vs. 88 mg/dl + 79.4 mg/dl; p = 0.03) and increase in the urinary volume (1,183 ml/day vs. 1,778 ml/day; p = 0.03); there was no tendency to creatinine decrease (2.0 mg/dl + 0.8 mg/dl vs. 1.7 mg/dl + 1.0 mg/dl; p = 0.08). Despite the elevation in sodium levels (131 mEq/l + 2.8 mEq/l vs. 134 mEq/l + 4.9 mEq/l) and weight decrease (69.5 kg + 18.6 kg vs. 68.2 kg + 17.1 kg), there was no statistically significant difference. CONCLUSION: The use of hypertonic saline solution in patients with decompensated heart failure can be a safe therapeutic method and potentially related to clinical improvement and renal failure prevention.

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14.

Jurandir Gonçalves de Aguiar (1948-2007)
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Naves, Rodrigo

Novos estudos CEBRAP

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jul 2007, N. 78 Pages 245 - 246

Abstract: Pt | Text: Pt | PDF: Pt

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15.

BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide
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Reyes S, Lilian I

; León B, Francisca

; Rozas V, M Fernanda

; González J, Patricia

; Naves P, Rodrigo

Revista médica de Chile

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sep 2006, Volume 134 N. 9 Pages 1175 - 1184

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

BAFF (B cell activating factor belonging to the TNF family) is a cytokine implicated in the survival and maturation of peripheral B lymphocytes and T and B cell activation. BAFF binds to three different receptors: TACI, BCMA and BAFF-R, whose expression is restricted to B and T lymphocytes. BAFF and BAFF-R-deficient mice show a dramatic loss of peripheral B lymphocytes and a severely reduced immune response. In contrast, an enhanced BAFF expression leads to B cell hyperplasia and autoimmunity in mice. In vivo, administration of soluble decoy receptors for BAFF effectively decreases disease progression in various autoimmune mouse models. These evidences render BAFF as a potentially new therapeutic target. Elevated BAFF levels have been detected in the serum of patients with autoimmune diseases, such as Systemic Lupus Erythematosus, rheumatoid arthitis, Sjögren's syndrome, lymphoid cancers and HIV infection. In addition to BAFF receptors, malignant B cells abnormally express BAFF, which attenuates apoptosis through both autocrine and paracrine pathways. The data suggest that an increase in the expression of BAFF induces an enhanced B and T cell activation and the survival of pathologically active B cells. In this article, we review and discuss the participation of BAFF and its receptors in the immune response and its involvement in immunodeficiency, autoimmunity, infections and lymphoid cancers as well as the currently investigated therapies using BAFF antagonists in the treatment of these diseases

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