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Energy levels and lysine, calcium and phosphorus adjustments on broiler nutrient digestibility and performance
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FEITOSA, VICTOR EMANUEL M.

; SILVA, CAMILLA M.

; RIBEIRO JÚNIOR, VALDIR

; OLIVEIRA, CLAUDIO JOSE P. DE

; VARGAS JÚNIOR, JOSÉ GERALDO DE

; BARROS NETO, ANTÔNIO P. DE

; ALBINO, LUIZ FERNANDO T.

; BRITO, CLAUDSON O.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 N. 4 elocation e20191391

Abstract: En | Text: En | PDF: En

Abstract Chicken broilers digestibility and performance fed with different ME levels, with and without adjustments of digestible lysine, calcium, and available phosphorus, were evaluated. For digestibility, 210 male Cobb 500 chicken broilers were used and distributed into a 3x2+1 factorial arrangement, with three ME levels (3050; 3125 and 3200 kcal/kg) with and without nutrient adjustment, plus one control treatment (2975 kcal ME/kg), totaling seven treatments including six repetitions with five birds into each repetition. For initial performance, 1120 birds were distributed randomly with eight replications within treatments and 20 birds for each replication. For final performance, 1008 chickens were distributed with eight replications and 18 birds for each replication. The DCDM and DCCP were improved (P<0.05) according to the increase of ME and the adjustment in dietary nutrients, as well as GE digestibility. The final performance showed no interaction (P>0.05) between energy and nutrient adjustment, but the increase in energy levels improved the feed conversion ratio (FCR=1.370). Increasing energy density with nutrient adjustment improves both nutrient utilization and bird performance.

https://doi.org/10.1590/0001-3765202320191391

Temporary reduction of digestible lysine in nursery pig diets: performance and economic analysis
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CORREIA, Amanda Medeiros

; SARAIVA, Alysson

; TEIXEIRA, Lucas Medina

; SILVA, Francisco Carlos de Oliveira

; RIBEIRO JUNIOR, Valdir

; ROCHA, Gabriel Cipriano

Revista Brasileira de Saúde e Produção Animal

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2022, Volume 23 elocation e20222025

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivou-se com este estudo avaliar os efeitos da restrição temporária de lisina na dieta sobre o desempenho e viabilidade econômica de leitões em fase de creche. Foram utilizados 144 leitões, distribuídos em blocos ao acaso, com dois tratamentos e 12 repetições. Os tratamentos foram controle-lis, nível de lisina recomendado dos 21 aos 32 e 32 aos 42 dias de idade e baixa-lis, 90% do nível de lisina das dietas controle-lis. Dos 42 aos 62 dias, todos os animais receberam dieta controle. De 21 a 32 dias, leitões alimentados com baixa-lis tiveram pior ganho médio diário (GMD), conversão alimentar e peso corporal aos 32 dias (P≤0,05). Dos 32 aos 42 dias, leitões alimentados com baixa-lis apresentaram menor consumo médio de ração diário, GMD e peso aos 42 dias (P≤0,05). Dos 21 aos 62 dias, leitões alimentados com baixa-lis apresentaram GMD e peso corporal final menores (P≤0,05) quando comparados aos alimentados com controle-lis. At 27 and 29 days of age, pigs fed the low-lys diet had a higher (P≤0.05) incidence of diarrhea Aos 27 e 29 dias, leitões alimentados com baixa-lis apresentaram maior (P≤0.05) indicência de diarreia. O menor custo de alimentação e o maior índice de eficiência econômica foram registrados para baixa-lis. No entanto, os suínos alimentados com controle-lis apresentaram rentabilidade 3,9% maior. Como conclusão, a restrição temporária de lisina nas dietas de leitões piora o desempenho e diminui a viabilidade econômica.

ABSTRACT To evaluate the effects of temporary dietary lysine restriction on nursery pigs’ growth performance and its economic viability compared to control diets, 144 piglets (21-d-old) were assigned to randomized blocks, with two treatments and twelve replicates. The treatments were control-lys: lysine level as recommended from 21-32 and 32-42 days and low-lys: 90% of the lysine level of the control-lys diets. From 42 to 62 days, all animals received a control diet. From 21 to 32 days, pigs fed low-lys had worse average daily gain (ADG), feed conversion, and 32-d body weight (BW; P ≤ 0.05). From 32 to 42 days, pigs fed low-lys had lower average daily feed intake, ADG, and 42-d BW (P ≤ 0.05). From 42 to 62 days, pigs had similar performance (P > 0.05). Overall (21 to 62 days), pigs fed the low-lys had lower (P <0.05) ADG and final BW. At 27 and 29 days, pigs fed the low-lys diet had a higher (P≤0.05) incidence of diarrhea. The lowest feed cost and the highest economic efficiency index were recorded for the low-lys treatment. However, pigs fed the control-lys presented a 3.9% higher profitability. In conclusion, a temporary reduction of lysine in the diets of nursery pigs followed by an unrestricted diet in the subsequent period led to worse growth performance and lower economic viability.

https://doi.org/10.1590/s1519-994020222025

Atualização das Diretrizes Brasileiras de Valvopatias – 2020
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Tarasoutchi, Flavio

; Montera, Marcelo Westerlund

; Ramos, Auristela Isabel de Oliveira

; Sampaio, Roney Orismar

; Rosa, Vitor Emer Egypto

; Accorsi, Tarso Augusto Duenhas

; Santis, Antonio de

; Fernandes, João Ricardo Cordeiro

; Pires, Lucas José Tachotti

; Spina, Guilherme S.

; Vieira, Marcelo Luiz Campos

; Lavitola, Paulo de Lara

; Ávila, Walkiria Samuel

; Paixão, Milena Ribeiro

; Bignoto, Tiago

; Togna, Dorival Júlio Della

; Mesquita, Evandro Tinoco

; Esteves, William Antônio de Magalhães

; Atik, Fernando

; Colafranceschi, Alexandre Siciliano

; Moises, Valdir Ambrósio

; Kiyose, Alberto Takeshi

; Pomerantzeff, Pablo M. A.

; Lemos, Pedro A.

; Brito Junior, Fabio Sandoli de

; Weksler, Clara

; Brandão, Carlos Manuel de Almeida

; Poffo, Robinson

; Simões, Ricardo

; Rassi, Salvador

; Leães, Paulo Ernesto

; Mourilhe-Rocha, Ricardo

; Pena, José Luiz Barros

; Jatene, Fabio Biscegli

; Barbosa, Márcia de Melo

; Abizaid, Alexandre

; Ribeiro, Henrique Barbosa

; Bacal, Fernando

; Rochitte, Carlos Eduardo

; Fonseca, José Honório de Almeida Palma da

; Ghorayeb, Samira Kaissar Nasr

; Lopes, Marcelo Antonio Cartaxo Queiroga

; Spina, Salvador Vicente

; Pignatelli, Ricardo H.

; Saraiva, José Francisco Kerr

Arquivos Brasileiros de Cardiologia

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oct 2020, Volume 115 N. 4 Pages 720 - 775

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201047 17824 downloads

Organic trace minerals and calcium levels in broilers' diets to 21 days old
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Faria, Bruno Damaceno

; Silva, Leandro Moreira

; Ribeiro Junior, Valdir

; Ferreira, Adriana Helena do Nascimento

; Rostagno, Horacio Santiago

; Albino, Luiz Fernando Teixeira

; Hannas, Melissa Izabel

Scientia Agricola

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2020, Volume 77 N. 1 elocation e20180071

Abstract: En | Text: En | PDF: En

ABSTRACT: This study was undertaken to evaluate the effects of dietary calcium levels and supplementation with organic trace minerals selenium, copper, iron, zinc and manganese on performance, tissue deposition and litter mineral concentration. A total of 2,496 one-day-old male Cobb 500 broilers were randomly assigned to a 3 × 4 factorial experimental design with three levels of dietary Ca [8, 10 and 12 g kg–1, while maintaining the same Ca:nPP (non-phytate phosphorus) ratio (2:1)] and four levels of micromineral supplementation (0.62, 0.72, 0.82 and 0.92 g kg–1). There was a total of 12 treatments, with eight replicates of 26 birds per pen. Micromineral supplementation (MS) was achieved by adding different levels of the product Bioplex TR Se® and Ca supplementation was achieved by adding increasing levels of limestone and dicalcium phosphate. An interaction between Ca and MS levels was observed (p < 0.05) for the parameters of performance, liver Cu concentration, breast Se and Cu concentrations and litter Se, Mn and Zn concentrations. No interactions were observed (p > 0.05) for Ca, P or ash concentrations in the tibia, which were influenced only by dietary Ca levels (p < 0.05). The Ca level of 10 g kg–1 promoted higher Ca and P concentration in the tibia and lower micromineral excretion in the litter. The combination of MS level of 0.82 g kg–1 with Ca level of 10 g kg–1 led to the best BWG response. The supplementation conditions that led to higher micromineral levels in the liver and breast varied for each mineral.

https://doi.org/10.1590/1678-992x-2018-0071 1860 downloads

ESTERÓIS E CONSTITUINTES VOLÁTEIS DA ESPONJA DULCÍCOLA Trochospongilla paulula (BOWERBANK)
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Barros, Iuri B. de

; Ribeiro, Cecília Volkmer

; Veiga Junior, Valdir F. da

Química Nova

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nov 2015, Volume 38 N. 9 Pages 1192 - 1195

Abstract: Pt | Text: Pt | PDF: Pt

The Neotropical region has the highest freshwater sponge diversity in the world, with the presence of species of the families Metaniidae, Potamolepidae, and Spongillidae. Due to the remarkable lipid diversity in these organisms, this study aimed to characterize the sterols and volatile compounds of the sponge Trochospongilla paulula collected in the Tapajós River. Seven volatile compounds were identified, with the long-chain alcohols tetradecanol, pentadecanol, and hexadecanol representing 51.65% of this fraction. Cholesterol is the major sterol species, as reported for other species of the family Spongillidae; however, T. paulula may be distinguished by a chromatographic profile of its sterols.

https://doi.org/10.5935/0100-4042.20150134 1073 downloads

Diet supplementation with phytase on performance of broiler chickens
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Lelis, Guilherme Rodrigues

; Albino, Luiz Fernando Teixeira

; Calderano, Arele Arlindo

; Tavernari, Fernando de Castro

; Rostagno, Horacio Santiago

; Campos, Anastácia Maria de Araújo

; Araújo, Wagner Azis Garcia de

; Ribeiro Junior, Valdir

Revista Brasileira de Zootecnia

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apr 2012, Volume 41 N. 4 Pages 929 - 933

Abstract: En | Text: En | PDF: En

The assay was carried out to determine the effect of phytase supplementation on performance of broilers from 1 to 21 and 1 to 40 days of age. Twelve hundred and fifty male broilers (Ross) were distributed in a randomized experimental design, with five treatments, 10 repetitions and 25 birds per experimental unit. The treatments consisted of evaluating the phytase supplementation in diets with reductions in nutritional levels, compared with the positive control. The nutrient contents in negative controls one and two were reduced progressively and these diets were supplemented with phytase levels of 250 and 500 ftu/kg of the diet, respectively. Two diets were formulated: pre-starter/starter, 1-21 days, and growth/finishing, from 21 to 40 days). In both phases, with the phytase supplementation in diets that had their nutritional levels reduced (negative control one + 250 ftu and negative control two + 500 ftu), feed intake, weight gain and feed conversion of the birds were similar to the positive control. In the period from 1 to 40 days of age, with the diets supplemented with phytase, the productive efficiency index of the birds was similar to that of the positive control group. Supplementation with 250 ftu/kg and 500 ftu/kg phytase in diets with reduced nutritional levels improved broiler performance, resulting in parameters similar to those shown by broilers fed with the diet with normal levels of nutrients.

3677 downloads Cited 1 time in SciELO

Chemical composition and metabolizable energy values of feedstuffs for broiler chickens
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Silva, Eliane Aparecida da

; Albino, Luiz Fernando Teixeira

; Rostagno, Horacio Santiago

; Ribeiro Junior, Valdir

; Vieira, Rodolfo Alves

; Campos, Anastácia Maria de Araújo

; Messias, Rodrigo Knop Guazzi

Revista Brasileira de Zootecnia

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mar 2012, Volume 41 N. 3 Pages 648 - 654

Abstract: En | Text: En | PDF: En

The objective of this study was to estimate the values of apparent metabolizable energy and apparent metabolizable energy corrected for nitrogen balance and determine the chemical composition of the following feedstuffs: babassu meal, sunflower meal, corn gluten meal, babassu starch flour, meat and bones meal, beans, millet, cookies residue, pasta residue and bread-making residue. The traditional method of excreta collection was used with broilers in the period of 14 to 24 days of age, which were distributed in a completely randomized design with eleven treatments and six replicates of six birds each. Each feedstuff replaced the reference diet at levels of 30 or 40% depending on the type of feedstuff. Chicks were housed in cages fitted with trays to collect the excreta. The apparent metabolizable energy corrected for nitrogen balance (kcal/kg) on the natural matter of feedstuffs were: babassu meal, 1,116; sunflower meal, 1,607; corn gluten meal, 3,826; babassu flour starch, 1,731; meat and bone flour, 2,524; common beans, 693; millet, 3,046; cookies residue, 3,351; pasta residue, 3,543 and bread-making residue, 3,494.

6184 downloads Cited 2 times in SciELO

Utilização de xilanase em dietas compostas por milho e farelo de soja de poedeiras comerciais em postura
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Viana, Maurício Tárcio dos Santos

; Albino, Luiz Fernando Teixeira

; Rostagno, Horacio Santiago

; Silva, Eliane Aparecida da

; Vieira, Rodolfo Alves

; Ribeiro Junior, Valdir

Revista Brasileira de Zootecnia

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feb 2011, Volume 40 N. 2 Pages 385 - 390

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivou-se avaliar o efeito da adição da enzima xilanase (Econase XT25) sobre o metabolismo de nutrientes e o desempenho de poedeiras no período de 24 a 48 semanas de idade. Foram utilizadas 288 poedeiras, distribuídas em delineamento experimental inteiramente casualizado em arranjo fatorial 2 × 2, com dois níveis de energia metabolizável (2.900 e 2.755 kcal/kg) combinados ou não com a adição de xilanase (37,5 g/t de ração), totalizando quatro tratamentos (controle positivo; controle negativo; controle positivo + xilanase; e controle negativo + xilanase), avaliados com 12 repetições de 6 aves por unidade experimental. As dietas controle positivo e controle positivo + xilanase foram formuladas seguindo as recomendações das Tabelas Brasileiras (100% de energia metabolizável), enquanto as dietas controle negativo e controle negativo + xilanase foram calculadas reduzindo 5% da energia metabolizável. A adição da enzima xilanase à dieta controle negativo proporcionou produção de ovos e massa de ovos semelhante às observadas no grupo controle positivo. A redução de 5% de energia metabolizável ocasionou diminuição na produção de ovos, na massa de ovos, piora da conversão alimentar e aumento do consumo de ração. A composição dos ovos não foram influenciada pelas dietas. Os valores médios de energia metabolizável aparente corrigida são maiores em dietas com maior nível de energia metabolizável. A adição de xilanase melhorou a utilização da energia e a produção de ovos em dietas para galinhas poedeiras.

The objective of this study was to evaluate the effect of the addition of xylanase enzyme (Econase XT25) on the metabolism of nutrients and the performance of laying hens from 24 to 48 weeks of age. It was used 288 laying hens, distributed in a completely randomized design in a 2 × 2 factorial arrangement, with two levels of metabolizable energy (2,900 and 2,755 kcal/kg) combined or not with addition of xylanase enzyme (37.5 g/t of ration), totaling four treatments (positive control, negative control, positive control + xylanase; and negative control + xylanase), evaluated with 12 replicates of 6 birds per experimental unit. Positive control and positive control + xylanase diets were formulated following the recommendations by Tabelas Brasileiras (100% metabolizable energy) while negative control and negative control + xilanase diets were calculated by reducing 5% of metabolizable energy. The addition of xylanase enzyme to the negative control diet provided egg production and egg mass similar to the ones observed in the positive control group. Reduction of 5% of metabolizable energy resulted in a decrease in egg production, in egg mass, worsening in feed conversion and increase in feed intake. Composition of the eggs was not affected by the diets. The average values of corrected apparent metabolizable energy are higher in diets with higher level of metabolizable energy. The addition of enzyme xylanase improved the use of energy and egg production in diets for laying hens.

3933 downloads

Estudo clínico do retalho lateral do braço ampliado
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Gonçalves, Renato Ribeiro

; Cho, Álvaro Baik

; Souza, Fabiano Inácio de

; Rezende, Marcelo Rosa de

; Torres, Luciano Ruiz

; Mattar Junior, Rames

; Zumiotti, Arnaldo Valdir

Acta Ortopédica Brasileira

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2010, Volume 18 N. 6 Pages 331 - 334

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Avaliar prospectivamente os resultados obtidos no tratamento de pacientes portadores de lesões do revestimento cutâneo de dimensões menores ou iguais a 20cm de comprimento por 10cm de largura com a utilização do retalho microcirúrgico lateral do braço ampliado distalmente ao epicôndilo lateral do cotovelo. MÉTODOS: Foram operados 23 pacientes, 69,5% do sexo masculino, 73,9% de origem traumática e a região receptora foi o membro inferior em 65.2% dos casos. A idade variou de 6 a 62 anos, com média de 32 anos. O seguimento mínimo foi de 5 meses. RESULTADOS: Obtivemos sucesso na realização em 100% dos casos. As dimensões dos retalhos variaram de 9 a 20cm em comprimento, com média de 14cm e em largura, de 3 a 8 cm, com média de 5.5cm. A maior distância entre o epicôndilo lateral e a extremidade distal do retalho foi de 8 cm, variando de 2 cm até 8 cm, com média de 4.9cm. CONCLUSÃO: O retalho microcirúrgico lateral do braço ampliado distalmente ao epicôndilo lateral do cotovelo mostrou-se seguro para a cobertura cutânea de lesões de dimensões iguais ou menores a 20cm de comprimento por 10 cm de largura, com o prolongamento do retalho até 8cm distal ao epicôndilo lateral.

OBJECTIVE: To prospectively evaluate the results obtained in the treatment of patients with cutaneous lesions smaller or equal to 20cm long by 10cm wide with the use of lateral arm flap extended distally to the lateral epicondyle of the elbow. METHODS: 23 patients underwent surgery, 69.5% of them male, 73.9% of traumatic origin, and the receiving region was the lower limb in 65.2% of cases. The age ranged from 6 to 62 years, with an average of 32 years. Minimum follow-up care was 5 months. RESULTS: We succeeded in 100% of cases. The size of flaps ranged from 9 to 20 cm in length, with an average of 14cm, and width, from 3 to 8cm, with an average of 5.5cm. The greatest distance between the lateral epicondyle and the distal flap was 8cm, ranging from 2cm to 8cm, with an average of 4.9cm. CONCLUSION: The lateral arm flap, extended distally to the lateral epicondyle of the elbow, was safe to cover cutaneous lesions of size equal to or smaller than 20cm long by 10cm wide, with the extension of the flap up to 8cm distal to the lateral epicondyle.

4652 downloads

10.

The role of apoptosis in cisplatin-induced ototoxicity in rats
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Freitas, Marcos Rabelo De

; Figueiredo, Aline Almeida

; Brito, Gerly Anne de Castro

; Leitao, Renata Ferreira de Carvalho

; Carvalho Junior, Jose Valdir de

; Gomes Junior, Raimundo Martins

; Ribeiro, Ronaldo de Albuquerque

Brazilian Journal of Otorhinolaryngology

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oct 2009, Volume 75 N. 5 Pages 745 - 752

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Cisplatina é um agente quimioterápico frequentemente usado para o tratamento de várias linhagens de neoplasias. A ototoxicidade é um dos efeitos colaterais causadores de significativa morbidade e que limita sua utilização. Este estudo teve por objetivo avaliar o papel da apoptose na ototoxicidade por cisplatina. DESENHO DO ESTUDO: Estudo experimental. MATERIAL E MÉTODO: Ratos Wistar machos foram tratados com cisplatina, via intraperitoneal, nas doses de 24 e 16 mg/kg. Os animais foram avaliados através de emissões otoacústicas evocadas produtos de distorção (EOAPD) ou potenciais auditivos evocados de tronco encefálico (PAETE) no terceiro (D3) e quarto (D4) dias após o início da infusão das drogas. Em seguida suas cócleas foram removidas para estudo de imunoistoquímica para apoptose, método TUNEL. RESULTADOS: O grupo tratado com 24 mg/kg mostrou diminuição significativa da amplitude das EOAPD, fato não observado com a dose de 16 mg/kg. Ambas as doses promoveram aumento do limiar eletrofisiológico pelo PAETE no D3 e D4. A apoptose foi o mecanismo de lesão responsável pela ototoxicidade da cisplatina, dose de 16 mg/kg, quando os animais foram avaliados no D3. CONCLUSÃO: Apoptose pode estar envolvida no mecanismo de ototoxicidade pela cisplatina, na dependência da dose e tempo de avaliação da lesão.

Cisplatin is a chemotherapy agent frequently used to treat different types of neoplasia. Ototoxicity is one of the side-effects which cause significant morbidity and limits its use. This study aimed at assessing the role of apoptosis in cisplatin-induced ototoxicity. DESIGN: experimental study. MATERIALS AND METHODS: male Wistar rats were treated with intraperitoneal cisplatin, in the doses of 24 and 16 mg/kg. The animals were assessed by means of distortion product evoked otoacoustic emissions (DPEOAE) or brainstem evoked auditory potentials (BEAP) in the third (D3) and fourth (D4) days after drug infusion onset. Following that, their cochleas were removed for immunohistochemical studies of apoptosis - TUNEL method. RESULTS: the group treated with 24 mg/kg showed a significant reduction in DPEOAE amplitude, and such fact was not seen with the 16 mg/kg. Both doses caused an increase in BEAP electrophysiological threshold in D3 and D4. Apoptosis was the injury mechanism responsible for the cisplatin-induced ototoxicity - 16 mg/kg dose, when the animals were assessed on D3. CONCLUSION: apoptosis may be involved in the cisplatin-induced ototoxicity, depending on the dose and time of injury assessment.

3653 downloads Cited 1 time in SciELO

11.

Distortion-product otoacoustic emissions and auditory brainstem responses sensitivity assessment in cisplatin-induced ototoxicity in rats
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Freitas, Marcos Rabelo de

; Silva, Viviane Carvalho da

; Brito, Gerly Anne de Castro

; Carvalho Junior, José Valdir de

; Gomes Junior, Raimundo Martins

; Ribeiro, Ronaldo de Albuquerque

Brazilian Journal of Otorhinolaryngology

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aug 2009, Volume 75 N. 4 Pages 476 - 484

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Cisplatina (cisdiaminodicloroplatinum) é um agente quimioterápico usado para o tratamento de várias linhagens de neoplasias, mormente as de cabeça e pescoço. Sua ototoxicidade permanece sendo um dos efeitos colaterais causadores de significativa morbidade e limita sua utilização. OBJETIVO: Avaliar a sensibilidade das emissões otoacústicas evocadas produtos de distorção (EOAPD) e potenciais auditivos evocados de tronco encefálico (PAETE) na detecção da ototoxicidade secundária a diferentes doses e formas de administração de cisplatina em ratos. FORMA DE ESTUDO: Experimental. MATERIAL E MÉTODO: Ratos Wistar machos, administrou-se cisplatina por via intraperitoneal (IP) nas doses de 24 mg/kg, fracionada em três doses diárias ou 16 mg/kg em infusão única. Avaliaram-se os animais através de EOAPD ou PAETE no terceiro (D3) e quarto (D4) dias após o início da infusão das drogas. RESULTADOS: O grupo tratado com 24 mg/kg mostrou diminuição significativa da amplitude das EOAPD e aumento do limiar eletrofisiológico pelo PAETE. A dose de 16 mg/kg não foi capaz de promover redução significativa da amplitude das EOAPD, mas elevou o limiar auditivo dos animais, detectado através de PAETE. CONCLUSÃO: Em ratos, os PAETE foram mais sensíveis que as OEAPD na detecção da ototoxicidade por cisplatina para diferentes doses e formas de administração.

Cisplatin (cis-diamminedicloroplatinum) is an antineoplastic drug used in the treatment of a variety of cancers, especially head-and-neck cancer. Its ototoxicity, however, has been noted as a common side-effect which limits its use and causes significant morbidity. AIM: to assess distortion-product otoacoustic emissions (DPOAE) and brainstem evoked response audiometry (BERA) sensitivity to detect secondary ototoxicity caused by different doses and means of administration of cisplatin in rats. STUDY DESIGN: Experimental. MATERIAL AND METHODS: Male Wistar rats were intraperitoneally (i.p.) injected with 24 mg/kg cisplatin, divided into three equal doses (8mg/kg) or a single i.p. injection of 16 mg/kg. The animals were evaluated by distortion product otoacoustic emission (DPOAE) or brainstem evoked response audiometry (BERA) on the 3rd and 4th days after the cisplatin injection. RESULTS: Treatment with cisplatin 24 mg/kg resulted in significant DPOAE decrease and it raised the BERA electrophysiological threshold. The 16mg/kg dose could not significantly reduce the DPOAE amplitude, but it raised the animals' hearing thresholds - detected by the BERA. CONCLUSION: In rats, BERA was more sensitivity than DPOAE at detecting cisplatin-induced ototoxicity in rats considering different doses and means of administration.

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12.

I Diretriz de Dor Torácica na Sala de Emergência
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Bassan, Roberto

; Pimenta, Lúcia

; Leães, Paulo Ernesto

; Timerman, Ari

; Volschan, André

; Polanczyk, Carisi

; Clare, Cristina

; Silva Júnior, Delcio Gonçalves da

; Mesquita, Evandro Tinoco

; Abreu, Flávio Berriel

; Monteiro Júnior, Francisco das Chagas

; Greque, Gilmar Valdir

; Almeida, Gustavo Luis Gouvea de

; Correa Filho, Harry

; Lima, Luis Eduardo de Magalhães

; Oliveira, Maria das Graças Sousa de

; França Neto, Olímpio Ribeiro

; Gamarski, Roberto

; Silva, Sergio Gouveia de Araújo

; Campodonico Filho, Sidney

; Barbosa Filho, Waldomiro

Arquivos Brasileiros de Cardiologia

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aug 2002, Volume 79 Suppl. 2 Pages 1 - 22

Abstract: Pt | Text: Pt | PDF: Pt

165198 downloads Cited 4 times in SciELO

13.

Distribution of cardiac geometric patterns on echocardiography in essential hypertension. Impact of two criteria of stratification
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Rosa, Eduardo Cantoni

; Moisés, Valdir Ambrósio

; Sesso, Ricardo Cintra

; Kohlmann, Nárcia E. B.

; Plavnik, Frida Liane

; Zanella, Maria Teresa

; Ribeiro, Artur Beltrame

; Kohlmann Júnior, Osvaldo

Arquivos Brasileiros de Cardiologia

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may 2001, Volume 76 N. 5 Pages 362 - 368

Abstract: En | Text: En | PDF: En

PURPOSE: To evaluate 2 left ventricular mass index (LVMI) normality criteria for the prevalence of left ventricular geometric patterns in a hypertensive population ( HT ) . METHODS: 544 essential hypertensive patients, were evaluated by echocardiography, and different left ventricular hypertrophy criteria were applied: 1 - classic : men - 134 g/m² and women - 110 g/m² ; 2- obtained from the 95th percentil of LVMI from a normotensive population (NT). RESULTS: The prevalence of 4 left ventricular geometric patterns, respectively for criteria 1 and 2, were: normal geometry - 47.7% and 39.3%; concentric remodelying - 25.4% and 14.3%; concentric hypertrophy - 18.4% and 27.7% and excentric hypertrophy - 8.8% and 16.7%, which confered abnormal geometry to 52.6% and 60.7% of hypertensive. The comparative analysis between NT and normal geometry hypertensive group according to criteria 1, detected significative stuctural differences,"( *p < 0.05):LVMI- 78.4 ± 1.50 vs 85.9 ±0.95 g/m² *; posterior wall thickness -8.5 ± 0.1 vs 8.9 ± 0.05 mm*; left atrium - 33.3 ± 0.41 vs 34.7 ± 0.30 mm *. With criteria 2, significative structural differences between the 2 groups were not observed. CONCLUSION: The use of a reference population based criteria, increased the abnormal left ventricular geometry prevalence in hypertensive patients and seemed more appropriate for left ventricular hypertrophy detection and risk stratification.

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