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Abstract The aim of this study was to evaluate the time elapsed from first symptoms to the treatment of oral and oropharyngeal cancer (OOC) and to identify variables associated with treatment delay. This is an observational study with retrospective and prospective data collection. Patients with a diagnosis of OOC seen at the Head and Neck Surgery outpatient clinic of a Brazilian public hospital were included and followed up to treatment initiation. Participants answered a questionnaire for the collection of socioeconomic, demographic, cultural, and clinical information, as well as information about the time elapsed from first symptoms to the first appointment with a head and neck surgeon. Time to treatment was classified into four intervals: 1- first symptoms to first medical appointment; 2- first medical appointment to specialized medical care; 3- specialized medical care to preparation for treatment; and 4- preparation for treatment to treatment initiation. Bivariate statistics were computed. Out of 100 participants, nine died before treatment. Mean time to treatment was 217 days. Highest mean time was observed for interval 2 (94 days), followed by interval 1 (63 days), interval 4 (39 days), and interval 3 (21 days). At interval 1, a longer time was associated with severe alcohol consumption, severe smoking, and family history of cancer. At interval 2, the delay was associated with appointment with a general practitioner, clinical diagnosis of disease other than cancer, and antibiotic prescription. At interval 4, delay in treatment was associated with surgical treatment. Patients with OOC experience delays from symptom onset to treatment initiation. The longest interval was associated with professional delay, followed by patient delay in help-seeking.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0054

COVID-19 outcomes in people living with HIV: Peering through the waves
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Sales, Thaís Lorenna Souza

; Souza-Silva, Maíra Viana Rego

; Delfino-Pereira, Polianna

; Neves, João Victor Baroni

; Sacioto, Manuela Furtado

; Assis, Vivian Costa Morais de

; Duani, Helena

; Oliveira, Neimy Ramos de

; Sampaio, Natália da Cunha Severino

; Ramos, Lucas Emanuel Ferreira

; Schwarzbold, Alexandre Vargas

; Jorge, Alzira de Oliveira

; Scotton, Ana Luiza Bahia Alves

; Castro, Bruno Mateus de

; Silva, Carla Thais Cândida Alves da

; Ramos, Carolina Marques

; Anschau, Fernando

; Botoni, Fernando Antonio

; Grizende, Genna Maira Santos

; Nascimento, Guilherme Fagundes

; Ruschel, Karen Brasil

; Menezes, Luanna Silva Monteiro

; Castro, Luís César de

; Nasi, Luiz Antônio

; Carneiro, Marcelo

; Godoy, Mariana Frizzo de

; Nogueira, Matheus Carvalho Alves

; Guimarães Júnior, Milton Henriques

; Ziegelmann, Patricia Klarmann

; Almeida, Rafaela Charão de

; Francisco, Saionara Cristina

; Silveira Neto, Sidney Teodoro

; Araújo, Silvia Ferreira

; Avelino-Silva, Thiago Junqueira

; Aliberti, Márlon Juliano Romero

; Pires, Magda Carvalho

; Silva, Eduardo Sérgio da

; Marcolino, Milena Soriano

Clinics

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2023, Volume 78 elocation 100223

Abstract: En | Text: En | PDF: En

Abstract Objective To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.

https://doi.org/10.1016/j.clinsp.2023.100223

“I Was... Put in a Cage”: The Experience of COVID-19 Home Confinement among Older Adults Living Alone in Portugal*
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José, José Manuel Sousa de São

; Timonen, Virpi

; Teixeira, Ana Rita

; Amado, Carla Alexandra da Encarnação Filipe

; Santos, Sérgio Pereira dos

; Coelho, Patrícia Marina Paulo C. C. Severino

Revista Crítica de Ciências Sociais

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sep 2022, N. 128 Pages 111 - 134

Abstract: Pt Fr En | Text: Pt Fr En | PDF: Pt | PDF: Fr | PDF: En

Resumo Este artigo apresenta os resultados de um estudo qualitativo sobre o modo como adultos mais velhos a residirem sozinhos em Portugal experienciaram o primeiro confinamento domiciliário no contexto da pandemia de COVID-19 em 2020. O confinamento domiciliário foi marcado por experiências negativas, com exceção de um participante que teve uma combinação particularmente favorável de recursos e circunstâncias. As experiências negativas envolveram perdas em diversas áreas, como a privação de atividades fora de casa, de independência e de interações sociais presenciais. Perder as atividades fora de casa e a independência promoveu uma sensação de aprisionamento, enquanto a perda de interações sociais cara a cara desencadeou um sentimento de solidão física. Considerando as potenciais implicações negativas destas perdas, é crucial criar soluções inovadoras que possam mitigá-las em futuros confinamentos.

Résumé Cet article présente les résultats d’une étude qualitative sur la façon dont les adultes plus vieux vivant seuls au Portugal ont vécu le premier confinement à domicile dans le contexte de la pandémie de COVID-19 en 2020. Le confinement à domicile a été marqué par des expériences négatives, à l’exception d’un participant qui avait une combinaison particulièrement favorable de ressources et de circonstances. Les expériences négatives impliquaient des pertes dans plusieurs domaines, tels que la privation d’activités en dehors de la maison, l’indépendance et les interactions sociales face à face. La perte d’activités extérieures et d’indépendance a favorisé un sentiment d’emprisonnement, tandis que la perte d’interactions sociales en face à face a déclenché un sentiment de solitude physique. Compte tenu des implications négatives potentielles de ces pertes, il est crucial de créer des solutions innovantes qui peuvent les atténuer lors de futurs confinements.

Abstract This article presents findings of a qualitative study reporting older adults’ experiences of solitary home confinement during Portugal’s first COVID-19 lockdown in 2020. Home confinement was marked by negative experiences, with the exception of one participant who had a particularly favorable combination of resources and circumstances. Negative experiences involved losses in several areas, such as being deprived of out-of-home activities, independence and face-to-face social interactions. Losing out-of-home activities and independence promoted a sense of imprisonment, while losing face-to-face social interactions triggered a feeling of physical loneliness. Considering the potential negative implications of these losses, it is crucial to create innovative solutions that can mitigate them in future lockdowns.

https://doi.org/10.4000/rccs.13468

Biology and parasites of Pteronotus gymnonotus from the Caatinga shrublands of Ceará (Brazil)
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Silva, Shirley Seixas Pereira da

; Guedes, Patrícia Gonçalves

; Severino, Flávia Silva

; Almeida, Juliana Cardoso de

Therya

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2021, Volume 12 N. 1 Pages 131 - 137

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: Mormoopid bats are distributed from southern United States of America to Brazil and comprise the genera Mormoops and Pteronotus. Although forms of Mormoops in Bahia, Brazil were described for the Quaternary, only some of the extant species of Pteronotus occur in this country, including P. gymnonotus. The species distribution ranges from southeastern México to northeastern Bolivia and central Brazil. This work presents information about food preference, reproduction, and the ectoparasitological fauna of P. gymnonotus in the state of Ceará. Fieldwork took place over ten consecutive days in the rain and dry seasons, in 2000, 2012, 2013, and 2019, on trails within the Serra das Almas Private Natural Heritage Reserve. A total of 14 P. gymnonotus specimens were caught in the three main phytophysiognomies present in the region. They were inspected for ecto and endoparasites, and fecal material was collected and analyzed under a light microscope. Of the total collected females, four were pregnant and one was lactating in January, during the rain season. No food residues or evidence of endoparasites were observed in the gastric content of the animals. Regarding the fecal samples, fragments of insects were found and identified as belonging to the orders Coleoptera and Lepidoptera. Seven individuals were infested with ectoparasites of the subfamily Acari and newly described associations with Diptera genera are presented. Due to the scarcity of data about these bats in the Caatinga biome, data reported here help explain the ecological interactions of P. gymnonotus in this semiarid area in Brazil.

Resumen: Los murciélagos Mormopidos se distribuyen desde el sur de los Estados Unidos de América hasta Brasil y comprenden los géneros Mormoops y Pteronotus. Aunque las formas de Mormoops son conocidas para el Cuaternario de Bahía, Brasil, solamente algunas de las especies recientes de Pteronotus se encuentran en este país. La distribución de la especie comprende desde el sureste de México hasta el noroeste de Bolivia y centro de Brasil. Este estudio presenta información sobre la preferencia alimentaria, reproducción y fauna ectoparasitológica de P. gymnonotus en el Estado de Ceará. El trabajo de campo se llevó a cabo durante diez días consecutivos en las estaciones lluviosa y seca en los años 2000, 2012, 2013 y 2019 en senderos dentro de la Reserva Privada del Patrimonio Natural Serra das Almas. Se capturaron un total de 14 especímenes de P. gymnonotus en las tres principales fitofisionomías presentes en la región. Fueron inspeccionados en busca de ecto y endoparásitos y el material fecal se recogió y analizó con un microscopio óptico. Del total de hembras recolectadas en enero, cuatro estaban preñadas y una en lactancia, durante la época de lluvias. No se observaron residuos de alimentos ni evidencia de endoparásitos en el contenido gástrico de los animales. En cuanto a las muestras fecales, se encontraron fragmentos de insectos que se identificaron como pertenecientes a los órdenes Coleoptera y Lepidoptera. Siete individuos encontraron infestados por ectoparásitos pertenecientes a la subfamilia Acari y se presentan nuevas asociaciones con géneros del orden Diptera. Debido a la escasez de datos sobre estos murciélagos en el Bioma de Caatinga, los datos presentados aquí ayudan a comprender las interacciones ecológicas de P. gymnonotus en una zona semiárida de Brasil.

https://doi.org/10.12933/therya-21-1078 67 downloads

Use of pharmaceutical nanotechnology for the treatment of leishmaniasis
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Marques, Carine Santana Ferreira

; Machado Júnior, Jorge Barreto

; Andrade, Lucas Rannier de Melo

; Andrade, Luciana Nalone

; Santos, André Luis Souza dos

; Cruz, Maria do Socorro Pires e

; Chaud, Marco

; Fricks, Alini Tinoco

; Severino, Patrícia

Revista da Sociedade Brasileira de Medicina Tropical

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2019, Volume 52 elocation e20180246

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Abstract INTRODUCTION: Leishmaniasis is a global public health concern. Currently available treatments are associated with considerable side effects. The use of nanotechnology has shown promise for improving efficacy and bioavailability and minimizing side effects. METHODS: This study investigated available literature, including patents and scientific articles, to identify advances in the use of nanotechnology for the treatment of leishmaniasis. RESULTS: Our findings revealed a stable number of patents and scientific articles published over the past five years. CONCLUSIONS: There is a need to intensify research on the use of nanotechnology for the treatment of leishmaniasis.

https://doi.org/10.1590/0037-8682-0246-2018 1097 downloads

Habilidades Sociais em Universitários com Diferentes Experiências de Preparação para o Trabalho
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ZUTIÃO, Patricia

; COSTA, Carolina Severino Lopes da

; LESSA, Tatiane Cristina Rodrigues

Revista Brasileira de Educação Especial

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apr 2018, Volume 24 N. 2 Pages 261 - 276

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Este estudo teve como objetivos: a) comparar o repertório de habilidades sociais de alunos da Licenciatura em Educação Especial da UFSCar que participaram de estágio curricular obrigatório e/ou do Programa Institucional de Bolsas de Iniciação à Docência (PIBID) com o de alunos que não vivenciaram tais experiências; b) comparar o repertório de habilidades sociais dos alunos que trabalharam com o dos que nunca trabalharam; c) correlacionar o repertório de habilidades sociais e variáveis sociodemográficas. A pesquisa ocorreu na universidade, contou com a participação de 75 alunos, com faixa etária entre 18 e 50 anos, sendo 66 do gênero feminino e nove do masculino. Os alunos responderam individualmente ou em grupo ao questionário inicial, questionário socioeconômico e Inventário de Habilidades Sociais. Foram utilizados três testes estatísticos, sendo o Teste t para comparar as habilidades sociais dos participantes que já trabalharam com o dos alunos que nunca trabalharam; o ANOVA para comparar as habilidades sociais entre os grupos; e a correlação de Pearson para verificar correlações entre as variáveis sociodemográficas e habilidades sociais. O estudo aponta melhores resultados entre os alunos que participaram de estágio com diferença estatisticamente significativa para o fator “Autoexposição a desconhecidos e situações novas” e melhor avaliação no fator “Autocontrole da agressividade” entre os que trabalharam. Assim, infere-se que as experiências práticas de estágio e PIBID têm potencial para auxiliar os alunos no aprimoramento de seu repertório de habilidades sociais. Contudo, essas contribuições poderiam ser mais robustas se tais habilidades fossem trabalhadas intencionalmente em disciplinas específicas.

ABSTRACT: This study aimed to: a) compare the repertoire of social skills of students from the Teaching Undergraduate Program in Special Education at the Federal University of São Carlos, who participated in the compulsory curricular internship and/or the Teaching Initiation Scholarship Institutional Program (known as PIBID) with students who did not have such experiences; b) compare the repertoire of social skills of students who worked with those who have never worked; c) correlate the repertoire of social skills and sociodemographic variables. The research took place in the University, with the participation of 75 students, aged between 18 and 50 years, with 66 being of the feminine gender and nine of the masculine. The students answered individually or in groups to the initial questionnaire, socioeconomic questionnaire and Social Skill Inventory. Three statistical tests were used, the t-Test to compare the social skills of the participants who had already worked with the students who never worked; ANOVA to compare the social skills among the groups; and the Pearson correlation to verify correlations among the sociodemographic variables and social skills. The study points out better results among the students who participated in the internship with a statistically significant difference for the ‘Self-exposure to strangers and new situations’ factor and a better evaluation of the ‘Self-control of aggressiveness’ factor among those who worked. Thus, it is inferred that practical internship and PIBID experiences have the potential to assist students in improving their repertoire of social skills. However, these contributions could be more robust if such skills were intentionally worked out in specific disciplines.

https://doi.org/10.1590/s1413-65382418000200008 2812 downloads

TRANSTIBIAL VERSUS ANTEROMEDIAL PORTAL TECHNIQUES IN ACL RECONSTRUCTION
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Guglielmetti, Luiz Gabriel Betoni

; Cury, Ricardo de Paula Leite

; Oliveira, Victor Marques de

; Camargo, Osmar Pedro Arbix de

; Severino, Fabrício Roberto

; Severino, Nilson Roberto

; Fucs, Patrícia Maria de Moraes Barros

Revista Brasileira de Medicina do Esporte

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oct 2016, Volume 22 N. 5 Pages 368 - 373

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Introdução: Embora a reconstrução do ligamento cruzado anterior (LCA) proporcione resultados clínicos bons e excelentes na maioria dos estudos, algumas questões ainda são discutidas e estudadas, como o posicionamento dos túneis. Objetivo: Comparar os resultados clínicos objetivos e subjetivos da reconstrução do LCA entre duas técnicas, a transtibial e a transportal medial. Métodos: Estudo prospectivo e randomizado de 80 pacientes submetidos à reconstrução do LCA pelo mesmo cirurgião, com 40 pacientes operados pela técnica transtibial e 40 pela técnica transportal medial. Ocorreram nove desistências, sendo 34 pacientes do grupo transtibial e 37 do grupo transportal medial, reavaliados durante dois anos de seguimento. A avaliação utilizou exame físico, avaliação com KT-1000TM, escores de Lysholm e (International Knee Documentation Committee) - IKDC (objetivo e subjetivo). Resultados: Nos testes de Lachman e pivot shift, foram observados mais casos de instabilidade no grupo transtibial, porém sem significância estatística (p = 0,300 e p = 0,634, respectivamente). Em relação ao teste de "gaveta anterior", os resultados foram semelhantes (p = 0,977). A avaliação com KT-1000TM apresentou resultado médio de 1,44 no grupo transtibial e 1,23 no grupo transportal medial, sem diferença estatística (p = 0,548). Os resultados do IKDC objetivo foram separados em 2 grupos: Grupo 1, pacientes com IKDC A e grupo 2, pacientes com IKDC B, C ou D, sem diferença estatisticamente significante (p = 0,208). Em relação ao escore de Lysholm, o grupo transtibial teve uma pontuação média de 91,32 e o grupo transportal medial teve 92,81. O escore médio do IKDC subjetivo foi de 90,65 no grupo transtibial e de 92,65 no grupo transportal medial. Três rerrupturas foram encontradas no grupo transtibial e três no grupo transportal medial. Conclusões: Não foram encontradas diferenças com significância estatística nas avaliações objetivas e subjetivas, ao comparar pacientes submetidos à reconstrução do LCA pelas técnicas transtibial e transportal medial.

Abstract Introduction: Although the results of anterior cruciate ligament (ACL) reconstruction are well documented in many studies, with good to excellent outcomes in most cases, some issues like tunnel positioning are still discussed and studied. Objective: To compare the objective and subjective clinical outcomes of ACL reconstruction using the transtibial and anteromedial portal techniques. Methods: Prospective randomized study of 80 patients undergoing anterior cruciate ligament reconstruction by the same surgeon, with 40 patients operated by the transtibial technique and 40 by anteromedial portal technique. The patients, 34 in the transtibial group and 37 in the anteromedial portal group (nine dropouts), were reassessed during a 2-year follow-up period. The clinical assessment consisted of physical examination, KT-1000TM evaluation, Lysholm score, and objective and subjective International Knee Documentation Committee - IKDC scores. Results: Regarding the Lachman and pivot shift tests, we observed more cases of instability in the transtibial group, but with no statistical significance (p=0.300 and p=0.634, respectively). Regarding the anterior drawer test, the groups presented similar results (p=0.977). Regarding KT-1000TM evaluation, the mean results were 1.44 for the transtibial group and 1.23 for the anteromedial portal group, with no statistical significance (p=0.548). We separated the objective IKDC scores into two groups: Group 1, IKDC A, and Group 2, IKDC B, C, or D, with no statistical significance (p=0.208). Concerning the Lysholm score, the transtibial group had a mean score of 91.32, and the anteromedial portal group had a mean score of 92.81. The mean subjective IKDC scores were 90.65 for the transtibial group and 92.65 for the anteromedial portal group. Three re-ruptures were encountered in the transtibial group and three in the anteromedial portal group. Conclusions: There were no significant differences in the subjective and objective clinical assessments among patients submitted to anterior cruciate ligament reconstruction using the transtibial or anteromedial portal techniques.

RESUMEN Introducción: Aunque los resultados del ligamento cruzado anterior (LCA) están bien documentados en numerosos estudios, con buenos a excelentes resultados en la mayoría de los casos, algunos temas como el posicionamiento del túnel todavía son discutidos y estudiados. Objetivo: Comparar los resultados clínicos objetivos y subjetivos de la reconstrucción del LCA utilizando la técnica transtibial y la técnica transportal. Métodos: Estudio prospectivo aleatorizado de 80 pacientes sometidos a reconstrucción del ligamento cruzado anterior por el mismo cirujano, con 40 pacientes operados mediante la técnica transtibial y 40 mediante técnica transportal. Hubo nueve pérdidas y 34 pacientes del grupo transtibial y 37 en del grupo transportal fueron re-evaluados durante un período de seguimiento de 2 años. La evaluación clínica consistió en examen físico, evaluación KT-1000TM, puntuaciones de Lysholm e (International Knee Documentation Committee) - IKDC objetiva y subjetiva. Resultados: En cuanto a la prueba de Lachman y la prueba de pivot shift, hemos observado más casos de inestabilidad en el grupo transtibial, pero sin significación estadística (p = 0,300 y p = 0,634, respectivamente). En cuanto a la prueba del cajón anterior, los grupos presentaron resultados similares (p = 0,977). En cuanto a la evaluación con KT-1000TM, los resultados promedio fueron de 1,44 para el grupo transtibial y 1,23 para el grupo transportal, sin significación estadística (p = 0,548). Separamos las puntuaciones IKDC objetivo en dos grupos: Grupo 1, pacientes con IKDC Ay Grupo 2, pacientes con IKDC B, C o D, sin significación estadística (p = 0,208). En lo que respecta a la puntuación de Lysholm, el grupo transtibial tenía puntuación media de 91,32 y el grupo transportal tuvo puntuación media de 92,81. Las puntuaciones medias de IKDC subjetivo fueron 90,65 para el grupo transtibial y 92,65 para el grupo transportal. Tres re-roturas fueron encontradas en el grupo transtibial y tres en el grupo transportal. Conclusiones: No hubo diferencias significativas en las evaluaciones clínicas subjetivas y objetivas entre los pacientes sometidos a la reconstrucción del ligamento cruzado anterior utilizando las técnicas transtibial y transportal.

https://doi.org/10.1590/1517-869220162205159722 2474 downloads

A novel dosage form for buccal administration of bupropion
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Almeida, Nilsa Maria Galvão

; Lima, Renata

; Alves, Thaís Francine Ribeiro

; Rebelo, Márcia de Araújo

; Severino, Patrícia

; Chaud, Marco Vinícius

Brazilian Journal of Pharmaceutical Sciences

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mar 2015, Volume 51 N. 1 Pages 91 - 100

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A bupropiona é um antidepressivo utilizado no tratamento do tabagismo. O objetivo deste trabalho foi a preparação de filmes hidrogelatinosos de liberação controlada para administração bucal de bupropiona. Os filmes foram preparados utilizando carboximetilcelulose sódica ultrapurificada, hidroxipropilmetilcelulose K4M e quitosana de média viscosidade. As características físico-químicas dos filmes foram avaliadas por microscopia eletrônica de varredura, teor de bupropiona, resistência mecânica (perfuração, relaxação, resiliência e tração) e citotoxicidade. Os resultados mostraram que os filmes em bicamada apresentaram teor de bupropiona de 121 mg por 9 cm2 de filme e que a bupropiona modifica a resistência mecânica dos filmes, sem, no entanto, inviabilizar o uso desta forma farmacêutica. Os estudos de citotoxicidade mostraram que as formulações dos filmes contendo bupropiona não causam dano celular. Este estudo mostrou que a bupropiona veiculada na forma de filme hidrogelatinoso pode ser uma alternativa útil no tratamento do tabagismo.

Bupropion is an antidepressant used in the treatment of smoking. The purpose of this study was to prepare controlled-release hydrogel films for buccal administration of bupropion and investigate its physicochemical and cytotoxic properties. The films were prepared from ultrapure sodium carboxymethylcellulose, hydroxypropylmethylcellulose K4M, and medium-viscosity chitosan. Evaluation of film physicochemical characteristics was based on scanning electron microscopy, bupropion content, mechanical strength (burst strength, relaxation, resilience, and traction), and cytotoxicity. Bupropion content in bilayer films was 121 mg per 9 cm2. The presence of bupropion modified film mechanical strength, but did not compromise the use of this pharmaceutical form. As shown by the cytotoxicity results, films containing bupropion did not cause cellular damage. Bupropion administration in the form of hydrogel films is a potentially useful alternative in the treatment of smoking.

https://doi.org/10.1590/S1984-82502015000100010 2442 downloads

Implicaciones de la seguridad del paciente en la práctica del cuidado de enfermería
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Lima, Fabiane da Silva Severino

; Souza, Natalia Pimentel Gomes

; Freire de Vasconcelos, Patricia

; Aires de Freitas, Consuelo Helena

; Bessa Jorge, Maria Salete

; De Souza Oliveira, Adriana Catarina

Enfermería Global

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jul 2014, Volume 13 N. 35 Pages 293 - 309

Abstract: En Pt Es | Text: En Pt Es | PDF: En | PDF: Pt | PDF: Es

The term safety is being increasingly discussed in the sanitary fields. Nursery is involved in this process as a direct promoter of security actions through their care practices. This study aimed to investigate how the term safety has been addressed in the national and international scenario of nursing care. Literature search based on scientific papers published in national and international journals indexed in databases Scientific Library (SciELO), Medical Literature Analysis and Retrieval System Online (MEDLINE) and SCOPUS published from 2007 to 2012. Data collection occurred in October 2012. In total, we selected 24 articles published in Portuguese, English and Spanish. The reported failures with compromised patient safety, were on oral or written communication between health professionals and between professionals and patients; drug therapy; procedures of health, and human factors related to work, such as fatigue, lack of motivation, overload and / or (dis) satisfaction. As promoters of safety are: patient-centered care / family communication and dialogue, open communication about the error; promotion of personnel management; improvement of the delivery system of health care, promoting prevention policies, measurement and evaluation of errors and standardization of practices. Nursing plays a crucial role in promoting patient safety by presenting up and finding more direct patient care. However, if this is not done carefully, it may generate errors and compromise the safety of care.

O termo segurança vem sendo cada vez mais discutido no âmbito sanitario. Estando a enfermagem implicada nesse processo como promotora direta de ações de segurança por meio de suas práticas de cuidado. Este trabalho objetivou-se investigar como o termo segurança vem sendo abordado no cenário do cuidado de enfermagem no âmbito nacional e internacional. Trata-se de uma revisão integrativa baseada em artigos científicos publicados em periódicos nacionais e internacionais indexados nas bases de dados Scientific Library (Scielo), Medical Literature Analysis and Retrieval System Online (MEDLINE) e SCOPUS e publicados no período de 2007 a 2012. A coleta de dados ocorreu no período de outubro de 2012. No total, foram selecionados 24 artigos, publicados na língua portuguesa, inglesa e espanhola. As falhas relatadas com comprometimento da segurança do paciente, foram: na comunicação oral ou escrita entre profissionais da equipe e entre profissional e paciente; terapêutica medicamentosa; realização de procedimentos de saúde; e fatores humanos relacionados ao trabalho, como cansaço, falta de motivação, sobrecarga e/ou (in)satisfação. Como promotores de segurança estão: cuidado centrado no paciente/família, comunicação e diálogo, comunicação aberta sobre o erro; promoção de gestão de pessoas; melhoria do sistema de prestação da assistência sanitária; promoção de políticas de prevenção, medição e avaliação dos erros e uniformização das práticas. A enfermagem desempenha um papel crucial na promoção da segurança do paciente por apresentar-se de forma mais constate e direta no cuidado ao paciente. Em contrapartida, se esse cuidado não for realizado com qualidade, pode ser gerador de erros e comprometer a segurança do cuidado.

El término seguridad viene siendo cada vez más discutido en el ámbito sanitario. Estando la Enfermería implicada en este proceso como promotora directa de acciones de seguridad por medio de sus prácticas de cuidado. Este trabajo tiene como objetivo investigar cómo el término seguridad viene siendo abordado en el escenario del cuidado de enfermería en el ámbito nacional e internacional. Investigación bibliográfica basada en artículos científicos publicados en revistas nacionales e internacionales indexadas en bases de datos Scientific Library (Scielo), Medical Literature Analysis and Retrieval System Online (MEDLINE) y SCOPUS, y publicadas en el período de 2007 a 2012. La recogida de datos ocurrió en el período de octubre de 2012. En total, fueron seleccionados 24 artículos, publicados en la lengua portuguesa, inglesa y española. Los fallos relatados con comprometimiento de seguridad del paciente fueron: en la comunicación oral o escrita entre profesionales del equipo y entre profesionales y paciente; terapéutica medicamentosa; realización de procedimientos de salud; y factores humanos relacionados al trabajo, como cansancio, falta de motivación, sobrecarga y/o (in)satisfacción. Como promotores de seguridad están: cuidado centrado en el paciente/familia, comunicación y diálogo, comunicación abierta sobre error; promoción de políticas de prevención, medición y evaluación de los errores y estandarización de las prácticas. La enfermería desempeña un papel crucial en la promoción de la seguridad del paciente por presentarse de forma más constante y directa en el cuidado al paciente. En contrapartida, si dicho cuidado no es realizado con calidad, puede ser generador de errores y comprometer la seguridad del cuidado.

8871 downloads

10.

UFV-M7: mutant yellow passionfruit genotype with photoperiod insensitivity for flowering
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Lira Júnior, José Severino de

; Flores, Patrícia Silva

; Bruckner, Cláudio Horst

Crop Breeding and Applied Biotechnology

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jun 2014, Volume 14 N. 2 Pages 128 - 131

Abstract: En | Text: En | PDF: En

The development and characteristics of UFV-M7, a mutant with photoperiod insensitivity to beginning of flowering, are described. This genotype was fortuitously obtained by regeneration of nodal segments, exposed to gamma radiation. The possibility of incorporating photoperiod insensitivity into cultivars for producing regions is discussed for latitudes where the photoperiod determines the seasonality of harvest.

https://doi.org/10.1590/1984-70332014v14n2c22 1308 downloads

11.

Vascular endothelial growth factor-A enhances indoleamine 2,3-dioxygenase expression by dendritic cells and subsequently impacts lymphocyte proliferation
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Marti, Luciana Cavalheiro

; Pavon, Lorena

; Severino, Patricia

; Sibov, Tatiana

; Guilhen, Daiane

; Moreira-Filho, Carlos Alberto

Memórias do Instituto Oswaldo Cruz

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feb 2014, Volume 109 N. 1 Pages 70 - 79

Abstract: En | Text: En | PDF: En

Dendritic cells (DCs) are antigen (Ag)-presenting cells that activate and stimulate effective immune responses by T cells, but can also act as negative regulators of these responses and thus play important roles in immune regulation. Pro-angiogenic vascular endothelial growth factor (VEGF) has been shown to cause defective DC differentiation and maturation. Previous studies have demonstrated that the addition of VEGF to DC cultures renders these cells weak stimulators of Ag-specific T cells due to the inhibitory effects mediated by VEGF receptor 1 (VEGFR1) and/or VEGFR2 signalling. As the enzyme indoleamine 2,3-dioxygenase (IDO) is recognised as an important negative regulator of immune responses, this study aimed to investigate whether VEGF affects the expression of IDO by DCs and whether VEGF-matured DCs acquire a suppressor phenotype. Our results are the first to demonstrate that VEGF increases the expression and activity of IDO in DCs, which has a suppressive effect on Ag-specific and mitogen-stimulated lymphocyte proliferation. These mechanisms have broad implications for the study of immunological responses and tolerance under conditions as diverse as cancer, graft rejection and autoimmunity.

https://doi.org/10.1590/0074-0276130252 2629 downloads

12.

Intercropping of corn, brachiaria grass and leguminous plants: productivity, quality and composition of silages
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Costa, Patrícia Monteiro

; Villela, Severino Delmar Junqueira

; Leonel, Fernando de Paula

; Araújo, Saulo Alberto do Carmo

; Araújo, Karoline Guedes

; Ruas, José Reinaldo Mendes

; Coelho, Felipe Soares

; Andrade, Vinícius Raimundi

Revista Brasileira de Zootecnia

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oct 2012, Volume 41 N. 10 Pages 2144 - 2149

Abstract: En | Text: En | PDF: En

The present study was carried out with the objective to evaluate the productive and qualitative characteristics of forages produced in systems of intercropping of corn, brachiaria grass and different leguminous plants. Productivity, bromatological composition and the fermentative profile of the silages from the following treatments were evaluated: corn in exclusive cultivation (CEC); intercropping of corn with brachiaria grass (CB); intercropping of corn, brachiaria grass and Calopogonium mucunoides (CBCal); intercropping of corn, brachiaria grass and Macrotyloma axillare (CBMac); and intercropping of corn, brachiaria grass and Stylozanthes capitata (CBSty). The experimental design utilized was completely randomized. For each type of cultivation, five plots or replications of three linear meters were harvested, and the material was separated. The variables assessed were: dry matter productivity per area; dry matter productivity of corn per area; crude protein production per area and productivity of total digestible nutrients per area. The material originated from the cultures was ensiled, with dry matter between 28 and 32%. After, the material was placed and compacted appropriately in bucket silos. A sample was collected from each replication for determination of the contents of DM, crude protein (CP), ether extract (EE), lignin, neutral and acid detergent fibers (NDF and ADF) and TDN. A fraction of the sample of silages from each treatment was compressed for extraction of the juice and determination of the silage quality. There was difference between the forms of cultivation for the dry matter production per hectare. The CEC with production of 11920.1 kg DM/ha did not differ from CB (8997.41 kg DM/ha) or CBCal (10452.10 kg DM/ha); however, it was superior to CBMac (8429.75 kg DM/ha) and to CBSty (8164.83 kg DM/ha). The contents of DM, CP, NDF, ADF, lignin and TDN did not differ between the silages from the different treatments. All the silages presented good quality with good fermentation patterns.

3119 downloads Cited 2 times in SciELO

13.

Yield and quality of silage of maize hybrids
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Araújo, Karoline Guedes

; Villela, Severino Delmar Junqueira

; Leonel, Fernando de Paula

; Costa, Patrícia Monteiro

; Fernandes, Leonardo de Oliveira

; Tamy, Wagner Pessanha

; Andrade, Vinícius Raimundi

Revista Brasileira de Zootecnia

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jun 2012, Volume 41 N. 6 Pages 1539 - 1544

Abstract: En | Text: En | PDF: En

The objective of this research was to identify the potential of maize hybrids for the production of silage. Hybrids 1671B, 2B433, 20A78, SHS4070, BX1280 and DKB390 were tested in a randomized block design with three replications. The hybrids yields were evaluated (average plant height, height of ear insertion, number of broken and lodged plants/ha, leaf:stem and ear:plant ratio and production of of DM, CP and TDN/ha). There was no difference between hybrids for the variables studied, except for the height of ear insertion. With respect to chemical characteristics, N-NH3/NT organic acids, and pH, there was also no difference between cultivars and hybrid silages are rated as of very good quality.

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14.

Desenvolvimento, produção e caracterização de nanocristais de fármacos pouco solúveis
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Fangueiro, Joana F.

; Marques, Inês R.

; Severino, Patrícia

; Santana, Maria Helena A.

; Souto, Eliana B.

Química Nova

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2012, Volume 35 N. 9 Pages 1848 - 1853

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.

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15.

Preparação de nanopartículas poliméricas a partir da polimerização de monômeros: parte I
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Souto, Eliana B.

; Severino, Patrícia

; Santana, Maria Helena A.

Polímeros

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2012, Volume 22 N. 1 Pages 96 - 100

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Nanopartículas poliméricas produzidas a partir de polímeros sintéticos, como copolímeros do ácido metacrílico, ésteres acrílicos ou metacrílicos, têm sido amplamente utilizadas na área farmacêutica para encapsulação de princípios ativos. Essas nanopartículas apresentam as vantagens de proteção, liberação controlada, melhor biodisponibilidade e menor toxicidade, proporcionando maior conforto aos pacientes e adesão ao tratamento. A produção das nanopartículas (nanocápsulas e nanosferas) por polimerização de monômeros é revisada e descrita neste artigo, evidenciando os parâmetros tecnológicos que interferem nas características físico-químicas das nanopartículas, como a solubilidade do princípio ativo, o volume e pH do meio de polimerização, a massa molar e concentração do monômero e a natureza e concentração do tensoativo.

Polymeric nanoparticles obtained from synthetic polymers such as copolymers of methacrylic acid, acrylic esters or metacrylics, have been widely used in pharmaceuticals for encapsulation of drugs. These nanoparticles have the advantages of drug protection, controlled release, improved bioavailability and lower toxicity, resulting in greater comfort to patients and compliance to the treatment. The production of nanoparticles (nanospheres and nanocapsules) by polymerization of monomers is reviewed and discussed in this article, highlighting the technological parameters that affect the physicochemical characteristics of nanoparticles, e.g. drug solubility, phase volume, pH of polymerization, molecular weight and monomer concentration, and the nature and concentration of the surfactant.

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