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Abstract Objective: To describe the health-related quality of life (QOL) in children with cerebral palsy (CP) associated with congenital Zika infection. Methods: Cross-sectional study of a consecutive series of children, followed in a referral multicentric rehabilitation network in Brazil. We invited the caregivers to respond to the Brazilian version of the Caregiver Priorities & Child Health Index of Life with Disabilities (CPCHILDTM) questionnaire. Statistical analysis was performed with the Statistical Package for the Social Sciences (SPSS) 26.0™. We used absolute and relative frequencies for categorical variables and mean and standard deviation for continuous variables. Results: The sample consisted of 193 children, at mean age of 50.3±7.6 months. We observed a predominance of children with cerebral palsy (CP) with Gross Motor Function Classification System (GMFCS) level V (93.7%). Epilepsy (88.4%) was the most common comorbidity. CPCHILDTM mean scores were activities of daily living (ADL)/personal care 43.2±12.6; positioning, transferring and mobility 33.7±16.5; comfort and emotions 84.4±15.2; communication and social interaction (CoSI) 48.2±24.3; health 70.9±17.1; and overall quality of life (OQOL) 72.1±17.1. Total score was 54.8±11.3. Conclusions: Among children with cerebral palsy (CP) related to congenital Zika syndrome, the quality of life (QOL) scores were very similar to other populations with cerebral palsy (CP). The activities of positioning, transferring and mobility had the greatest impact on health-related quality of life (QOL). Rehabilitation strategies and public policies should prioritize aspects related to mobility for this population.

RESUMO Objetivo: Descrever a qualidade de vida relacionada à saúde em crianças com paralisia cerebral associada à infecção congênita pelo zika. Métodos: Estudo transversal de série consecutiva de casos de crianças acompanhadas em uma rede multicêntrica de reabilitação no Brasil. Convidamos o(s) cuidador(es) a responder à versão brasileira do Caregiver Priorities & Child Health Index of Life with Disabilities (CPCHILDTM). A análise estatística foi realizada com o pacote estatístico Statistical Package for the Social Sciences (SPSS) 26.0™. Para variáveis categóricas, foram utilizadas frequências absolutas e relativas e, para variáveis contínuas, média e desvio padrão. Resultados: Cento e noventa e três crianças, com idade média de 50,3±7,6 meses, foram incluídas. Observou-se predomínio de crianças com paralisia cerebral Gross Motor Function Classification System (GMFCS) nível V (93,7%). Epilepsia (88,4%) foi a comorbidade mais comum. As pontuações médias do CPCHILDTM foram: atividades de vida diária/cuidados pessoais 43,2±12,6; posicionamento, transferência e mobilidade 33,7±16,5; conforto e emoções 84,4±15,2; comunicação e interação social 48,2±24,3; saúde 70,9±17,1; e qualidade de vida geral 72,1±17,1. A pontuação total foi 54,8±11,3. Conclusões: Entre as crianças com paralisia cerebral relacionada à síndrome do zika congênita, as atividades de posicionamento, transferência e mobilidade tiveram maior impacto na qualidade de vida relacionada à saúde, semelhantemente a outras etiologias de paralisia cerebral. As estratégias de reabilitação e as políticas públicas devem priorizar os aspectos relacionados à mobilidade dessa população.

https://doi.org/10.1590/1984-0462/2023/41/2022016

First isolation of West Nile virus in Brazil
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Martins, Lívia Caricio

; Silva, Eliana Vieira Pinto da

; Casseb, Livia Medeiros Neves

; Silva, Sandro Patroca da

; Cruz, Ana Cecília Ribeiro

; Pantoja, Jamilla Augusta de Sousa

; Medeiros, Daniele Barbosa de Almeida

; Martins Filho, Arnaldo Jorge

; Cruz, Ermelinda do Rosário Moutinho da

; Araújo, Marialva Tereza Ferreira de

; Cardoso, Jedson Ferreira

; Cunha, Marcos Antônio Correia Rodrigues da

; Almada, Gilton Luiz

; Romano, Alessandro Pecego Martins

; Santos, Maria Guadalupe Dias Pestana

; Rodrigues, Gilsa Aparecida Pimenta

; Chiang, Jannifer Oliveira

; Quaresma, Juarez Antonio Simões

; Carvalho, Valéria Lima

; Vasconcelos, Pedro Fernando da Costa

Memórias do Instituto Oswaldo Cruz

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2019, Volume 114 elocation e180332

Abstract: En | Text: En | PDF: En

BACKGROUND Serological evidence of West Nile virus (WNV) infection has been reported in different regions of Brazil from equine and human hosts but the virus had never been isolated in the country. OBJECTIVES We sought to identify the viral etiology of equine encephalitis in Espírito Santo state. METHODS We performed viral culture in C6/36 cells, molecular detection of WNV genome, histopathology and immunohistochemistry from horse cerebral tissue. We also carried out sequencing, phylogenetic analysis and molecular clock. FINDINGS Histopathologic analysis from horse cerebral tissue showed injury related to encephalitis and WNV infection was confirmed by immunohistochemistry. The virus was detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR) from brain tissue and subsequently isolated in C6/36 cells. WNV full-length genome was sequenced showing the isolated strain belongs to lineage 1a. The molecular clock indicated that Brazilian WNV strain share the same common ancestor that were circulating in US during 2002-2005. MAIN CONCLUSIONS Here we report the first isolation of WNV in Brazil from a horse with neurologic disease, which was clustered into lineage 1a with others US WNV strains isolated in beginning of 2000’s decade.

https://doi.org/10.1590/0074-02760180332 3810 downloads

Encephalitis associated with Zika virus infection and reactivation of the varicella-zoster virus in a Brazilian child
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Vieira, Marcelo Adriano da Cunha e Silva

; Castro, Alzira Almeida de Sousa

; Henriques, Daniele Freitas

; Silva, Eliana Vieira Pinto da

; Tavares, Fernando Neto

; Martins, Lívia Carício

; Guimarães, Lucas Melo

; Monteiro, Talita Antonia Furtado

; Azevedo, Raimunda do Socorro da Silva

; Cruz, Ana Cecíclia Ribeiro

; Vasconcelos, Pedro Fernando da Costa

Revista da Sociedade Brasileira de Medicina Tropical

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jun 2018, Volume 51 N. 3 Pages 390 - 392

Abstract: En | Text: En | PDF: En

Abstract We report a case of encephalitis associated with Zika virus infection and reactivation of varicella-zoster virus in the central nervous system of a Brazilian child. This case raises the possibility that reactivation of the latent varicella-zoster virus may be a mechanism of neurological impairment induced by acquired Zika virus infection.

https://doi.org/10.1590/0037-8682-0447-2017 1559 downloads

Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases
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Vieira, Marcelo Adriano da Cunha e Silva

; Costa, Carlos Henrique Nery

; Linhares, Alexandre da Costa

; Borba, Amariles de Sousa

; Henriques, Daniele Freitas

; Silva, Eliana Vieira Pinto da

; Tavares, Fernando Neto

; Batista, Francisca Miriane de Araújo

; Guimarães, Herlon Clístenes Lima

; Martins, Lívia Carício

; Monteiro, Talita Antônia Furtado

; Cruz, Ana Cecília Ribeiro

; Azevedo, Raimunda do Socorro da Silva

; Vasconcelos, Pedro Fernando da Costa

Memórias do Instituto Oswaldo Cruz

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2018, Volume 113 N. 11 elocation e170538

Abstract: En | Text: En | PDF: En

This study showed that laboratory markers of recent infection by dengue, Zika or chikungunya arboviruses were detected in the biological samples of approximately one-third of patients with encephalitis, myelitis, encephalomyelitis or Guillain-Barré syndrome, in a surveillance programme in Piauí state, Brazil, between 2015-2016. Fever and myalgia had been associated with these cases. Since in non-tropical countries most infections or parainfectious diseases associated with the nervous system are attributed to herpesviruses, enteroviruses, and Campylobacter jejuni, the present findings indicate that in tropical countries, arboviruses may now play a more important role and reinforce the need for their surveillance and systematic investigation in the tropics.

https://doi.org/10.1590/0074-02760170538 2004 downloads

Guillain-Barré syndrome and dengue-like disease in 2015: temporal relationship in Piauí state and implications on Zika virus surveillance
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Vieira, Marcelo Adriano da Cunha e Silva

; Cruz, Ana Cecília Ribeiro

; Barros, Ananda Naya Mesquita

; Costa, Dorcas Lamounier

; Silva, Eliana Vieira Pinto da

; Batista, Francisca Miriane de Araújo

; Azevedo, Raimunda do Socorro da Silva

; Rodrigues, Sueli Guerreiro

; Araújo-Júnior, Rui Cipriano

; Vasconcelos, Pedro Fernando da Costa

Revista do Instituto de Medicina Tropical de São Paulo

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2017, Volume 59 elocation e22

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/s1678-9946201759022 2286 downloads

Análise dos registros das prescrições medicamentosas em um hospital universitário
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Silva, Flávia Janólio Costacurta Pinto da

; Almeida, Elizabeth Santana Alves de

; Rocha, Flávia Calixto

; Santana, Maria Aparecida Vieira

; Silva, Elis Carla Costa Matos

; Lemos, Lígia Mara Dolce de

; LLapa-Rodríguez, Eliana Ofelia

Reme: Revista Mineira de Enfermagem

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sep 2015, Volume 19 N. 3 Pages 539 - 546

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

OBJECTIVE: to analyze drug prescriptions in three inpatient units of a university hospital in the State of Sergipe. METHOD: this was a descriptive, transversal, and documental study. Data were collected in inpatient units during ten days in March of 2012. The sample consisted of 286 prescriptions with 2,605 items related to drugs. The study was approved by the Ethics and Research Committee of the Federal University of Sergipe, under number CAAE 0263.0.107.000-11. RESULTS: out of the total prescriptions analyzed, 48% were typed, 98% did not show the patients record number, and 100.0% contained abbreviations and acronyms. Out of the 4,522 prescribed drugs, a prevalence in the absence of dosage form, drug name, and other data on the medication was observed. CONCLUSION: the existence of inadequacies in the records of drug prescriptions has shown that the administration of drugs in the studied institution can pose risks to patient safety, indicating the need for the implementation of corrective actions.

El objetivo del presente estudio fue analizar las recetas de los medicamentos de tres unidades de internación de un hospital universitario del Estado de Sergipe. Se trata de un estudio transversal, descriptivo y documental. Los datosfueron recogidos en las unidades de internación durante 10 días del mes de marzo de 2012. La muestra consistió en 286 recetas con 2.605 insumos relacionados con los medicamentos. Este estudio fue aprobado por el Comité de Ética de la Universidad Federal de Sergipe, bajo el nº CAAE 0263.0.107.000-11. El 48% del total de las recetas analizadas estaban digitadas, en 98% no figuraba el número de protocolo del paciente y 100,0% tenían abreviaturas y siglas. De las 4.522 dosis recetadas, se observó que prevalece la falta de la forma farmacêutica, nombre del medicamento y otros datos referentes a la medicación. La falta de adecuaciones en los archivos de las recetas de los medicamentos mostró que en este hospital la administración de medicamentos puede presentar riesgos para la seguridad del paciente, lo cual sehala la necesidad de tomar medidas correctivas.

OBJETIVO: analisar as prescrições medicamentosas em três unidades de internação de um hospital universitário no estado de Sergipe. MÉTODO: estudo descritivo, transversal e documental. Os dados foram coletados nas unidades de internação pelo período de 10 dias durante o mês de março de 2012. A amostra compreendeu 286 prescrições com 2.605 itens referentes a medicamentos. A pesquisa foi aprovada pelo Comitê de Ética e Pesquisa da Universidade Federal de Sergipe, sob o nº CAAE 0263.0.107.000-11. RESULTADOS: do total das prescrições analisadas, 48% estavam digitadas, em 98% não constava o número do registro do paciente e 100,0% continham abreviaturas e siglas. Das 4.522 doses medicamentosas prescritas, foi observada prevalência de ausência da forma farmacêutica, nome do fármaco e outros dados relativos à medicação. CONCLUSÃO: a existência de inadequações nos registros das prescrições medicamentosas comprovou que a administração de medicamentos na instituição pode apresentar riscos à segurança do paciente, indicando a necessidade de implementar ações corretivas.

https://doi.org/10.5935/1415-2762.20150042 139 downloads

Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil
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Machado, Vanessa Wolff

; Vasconcelos, Pedro Fernando da Costa

; Silva, Eliana Vieira Pinto

; Santos, João Barberino

Revista da Sociedade Brasileira de Medicina Tropical

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apr 2013, Volume 46 N. 2 Pages 166 - 171

Abstract: En | Text: En | PDF: En

IntroductionThe yellow fever epidemic that occurred in 1972/73 in Central Brazil surprised the majority of the population unprotected. A clinical-epidemiological survey conducted at that time in the rural area of 19 municipalities found that the highest (13.8%) number of disease cases were present in the municipality of Luziânia, State of Goiás.MethodsThirty-eight years later, a new seroepidemiological survey was conducted with the aim of assessing the degree of immune protection of the rural population of Luziânia, following the continuous attempts of public health services to obtain vaccination coverage in the region. A total of 383 volunteers, aged between 5 and 89 years and with predominant rural labor activities (75.5%), were interviewed. The presence of antibodies against the yellow fever was also investigated in these individuals, by using plaque reduction neutralization test, and correlated to information regarding residency, occupation, epidemiological data and immunity against the yellow fever virus.ResultsWe found a high (97.6%) frequency of protective titers (>1:10) of neutralizing antibodies against the yellow fever virus; the frequency of titers of 1:640 or higher was 23.2%, indicating wide immune protection against the disease in the study population. The presence of protective immunity was correlated to increasing age.ConclusionsThis study reinforces the importance of surveys to address the immune state of a population at risk for yellow fever infection and to the surveillance of actions to control the disease in endemic areas.

https://doi.org/10.1590/0037-8682-0007-2012 3941 downloads

Environmental influences on antibody-enhanced dengue disease outcomes
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Diniz, Daniel Guerreiro

; Fôro, César Augusto Raiol

; Turiel, Maíra C Pereira

; Sosthenes, Marcia CK

; Demachki, Sâmia

; Gomes, Giovanni Freitas

; Rego, Carla M Damasceno

; Magalhães, Marina Cutrim

; Pinho, Brunno Gomes

; Ramos, Juliana Pastana

; Casseb, Samir M Moraes

; Brito, Maysa de Vasconcelos

; Silva, Eliana Vieira Pinto da

; Nunes, Marcio Roberto Teixeira

; Diniz, José Antonio Picanço

; Cunningham, Colm

; Perry, Victor Hugh

; Vasconcelos, Pedro F Costa

; Diniz, Cristovam W Picanço

Memórias do Instituto Oswaldo Cruz

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dec 2012, Volume 107 N. 8 Pages 1021 - 1029

Abstract: En | Text: En | PDF: En

Because an enriched environment (EE) enhances T-cell activity and T-lymphocytes contribute to immunopathogenesis during heterologous dengue virus (DENV) infections, we hypothesised that an EE increases dengue severity. To compare single serotype (SS) and antibody-enhanced disease (AED) infections regimens, serial intraperitoneal were performed with DENV3 (genotype III) infected brain homogenate or anti-DENV2 hyperimmune serum followed 24 h later by DENV3 (genotype III) infected brain homogenate. Compared AED for which significant differences were detected between the EE and impoverished environmental (IE) groups (Kaplan-Meyer log-rank test, p = 0.0025), no significant differences were detected between the SS experimental groups (Kaplan-Meyer log-rank test, p = 0.089). Survival curves from EE and IE animals infected with the AED regimen were extended after corticoid injection and this effect was greater in the EE than in the IE group (Kaplan-Meyer log-rank test, p = 0.0162). Under the AED regimen the EE group showed more intense clinical signs than the IE group. Dyspnoea, tremor, hunched posture, ruffled fur, immobility, pre-terminal paralysis, shock and death were associated with dominant T-lymphocytic hyperplasia and presence of viral antigens in the liver and lungs. We propose that the increased expansion of these memory T-cells and serotype cross-reactive antibodies facilitates the infection of these cells by DENV and that these events correlate with disease severity in an EE.

3419 downloads

Molecular characterisation of dengue virus type 1 reveals lineage replacement during circulation in Brazilian territory
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Carneiro, Adriana Ribeiro

; Cruz, Ana Cecília Ribeiro

; Vallinoto, Marcelo

; Melo, Diego de Vasconcelos

; Ramos, Rommel Thiago J

; Medeiros, Daniele Barbosa Almeida

; Silva, Eliana Vieira Pinto da

; Vasconcelos, Pedro Fernando da Costa

Memórias do Instituto Oswaldo Cruz

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sep 2012, Volume 107 N. 6 Pages 805 - 812

Abstract: En | Text: En | PDF: En

Dengue fever is the most important arbovirus infection found in tropical regions around the world. Dispersal of the vector and an increase in migratory flow between countries have led to large epidemics and severe clinical outcomes, such as dengue haemorrhagic fever and dengue shock syndrome. This study analysed the genetic variability of the dengue virus serotype 1 (DENV-1) in Brazil with regard to the full-length structural genes C/prM/M/E among 34 strains isolated during epidemics that occurred in the country between 1994-2011. Virus phylogeny and time of divergence were also evaluated with only the E gene of the strains isolated from 1994-2008. An analysis of amino acid differences between these strains and the French Guiana strain (FGA/89) revealed the presence of important nonsynonymous substitutions in the amino acid sequences, including residues E297 (Met→Thr) and E338 (Ser→Leu). A phylogenetic analysis of E proteins comparing the studied isolates and other strains selected from the GenBank database showed that the Brazilian DENV-1 strains since 1982 belonged to genotype V. This analysis also showed that different introductions of strains from the 1990s represented lineage replacement, with the identification of three lineages that cluster all isolates from the Americas. An analysis of the divergence time of DENV-1 indicated that the lineage circulating in Brazil emerged from an ancestral lineage that originated approximately 44.35 years ago.

4702 downloads Cited 3 times in SciELO

10.

Persistence of experimental Rocio virus infection in the golden hamster (Mesocricetus auratus)
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Henriques, Daniele Freitas

; Quaresma, Juarez Antonio Simões

; Fuzii, Helen Thais

; Nunes, Márcio Roberto Teixeira

; Silva, Eliana Vieira Pinto da

; Carvalho, Valéria Lima

; Martins, Lívia Carício

; Casseb, Samir Mansour Moraes

; Chiang, Jannifer Oliveira

; Vasconcelos, Pedro Fernando da Costa

Memórias do Instituto Oswaldo Cruz

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aug 2012, Volume 107 N. 5 Pages 630 - 636

Abstract: En | Text: En | PDF: En

Rocio virus (ROCV) is an encephalitic flavivirus endemic to Brazil. Experimental flavivirus infections have previously demonstrated a persistent infection and, in this study, we investigated the persistence of ROCV infection in golden hamsters (Mesocricetus auratus). The hamsters were infected intraperitoneally with 9.8 LD50/0.02 mL of ROCV and later anaesthetised and sacrificed at various time points over a 120-day period to collect of blood, urine and organ samples. The viral titres were quantified by real-time-polymerase chain reaction (qRT-PCR). The specimens were used to infect Vero cells and ROCV antigens in the cells were detected by immunefluorescence assay. The levels of antibodies were determined by the haemagglutination inhibition technique. A histopathological examination was performed on the tissues by staining with haematoxylin-eosin and detecting viral antigens by immunohistochemistry (IHC). ROCV induced a strong immune response and was pathogenic in hamsters through neuroinvasion. ROCV was recovered from Vero cells exposed to samples from the viscera, brain, blood, serum and urine and was detected by qRT-PCR in the brain, liver and blood for three months after infection. ROCV induced histopathological changes and the expression of viral antigens, which were detected by IHC in the liver, kidney, lung and brain up to four months after infection. These findings show that ROCV is pathogenic to golden hamsters and has the capacity to cause persistent infection in animals after intraperitoneal infection.

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