Resumen Objetivo Proponer un diagrama de prevención de caídas para personas mayores, basado en el modelo de promoción de la salud de Nola Pender. Métodos La elaboración del diagrama se basó en el modelo de Nola Pender y sus elementos. Para tal fin, se realizó un estudio de revisión integradora con el objetivo de recopilar datos sobre características y experiencias individuales, sentimientos y conocimientos y adopción de un comportamiento saludable para la prevención de caídas. Después de recopilar la información, se realizó un análisis de similitud de los estudios seleccionados mediante IRaMuTeQ. Los elementos obtenidos del análisis de similitud permitieron agrupar los estudios respecto a los elementos encontrados y, de esta forma, proporcionaron la organización del diagrama de prevención de caídas. Resultados La muestra final estuvo compuesta por 54 artículos, divididos de acuerdo con los elementos del modelo de Nola Pender: 36 abordaban características y experiencias individuales, 40 sentimientos y conocimientos y 20 eran sobre el comportamiento. Los elementos obtenidos del análisis de similitud generaron un conjunto semántico de palabras más frecuentes: caída, prevención, mujer y miedo. Por otro lado, las palabras menos frecuentes fueron: cognición, autoeficacia, transporte y planificación, que contribuyeron para la elaboración del diagrama. Conclusión A partir de la revisión, se elaboró un diagrama que favoreció la identificación de los factores personales, barreras y facilidades para un comportamiento conveniente en la prevención de caídas.

Resumo Objetivo Propor um diagrama de prevenção de quedas para pessoas idosas, baseado no Modelo de Promoção da Saúde de Nola Pender. Métodos A construção do diagrama foi embasada no modelo de Nola Pender e em seus elementos. Para isso, foi realizado um estudo de revisão integrativa, com o objetivo de coletar dados sobre características e experiências individuais, sentimentos e conhecimentos e adoção de comportamento saudável para prevenção de quedas. Após a coleta dessas informações, realizou-se análise de similitude dos estudos selecionados por meio do IRaMuTeQ. Os elementos obtidos da análise de similitude facilitaram o agrupamento dos estudos quanto aos elementos encontrados e, assim, proporcionaram a organização do diagrama de prevenção de quedas. Resultados A amostra final foi constituída de 54 artigos, divididos de acordo com os elementos do modelo de Nola Pender: 36 abordavam características e experiências individuais, 40 sentimentos e conhecimentos, e 20 eram referentes ao comportamento. Os elementos obtidos da análise de similitude geraram um leque semântico de palavras mais frequentes: queda, prevenção, mulher e medo. Já as palavras menos frequentes foram cognição, autoeficácia, transporte e planejamento, os quais contribuíram para a construção do diagrama. Conclusão A partir da revisão, elaborou-se um diagrama, que favoreceu a identificação dos fatores pessoais, barreiras e facilidades, para um comportamento desejável à prevenção de quedas.

Abstract Objective To propose a fall prevention diagram for older adults, based on Nola Pender’s Health Promotion Model. Methods Diagram construction was based on Nola Pender’s model and its elements. For this, an integrative review study was carried out with the objective of collecting data on individual characteristics and experiences, behavior-specific cognitions and affect and behavioral outcome for fall prevention. After collecting this information, a similarity analysis of the selected studies was carried out using IRaMuTeQ. The elements obtained from similarity analysis facilitated the grouping of studies regarding the elements found and thus provided fall prevention diagram organization. Results The final sample consisted of 54 articles, divided according to the elements of Nola Pender’s model: 36 addressed individual characteristics and experiences, 40 referred to behavior-specific cognitions and affect, and 20 referred to behavioral outcome. The elements obtained from the similarity analysis generated a semantic range of the most frequent words: fall, prevention, woman and fear. The least frequent words were cognition, self-efficacy, transportation and planning, which contributed to diagram construction. Conclusion From the review, a diagram was prepared, which favored identifying personal factors, barriers and facilities for a desirable behavior to prevent falls.

Objectives: To summarize evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The literature on CBT interventions for adult OCD, including BT and exposure and response prevention, was systematically reviewed to develop updated clinical guidelines for clinicians, providing comprehensive details about the necessary procedures for the CBT protocol. We searched the literature from 2013-2020 in five databases (PubMed, Cochrane, Embase, PsycINFO, and Lilacs) regarding study design, primary outcome measures, publication type, and language. Selected articles were assessed for quality with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association. Results: We examined 44 new studies used to update the 2013 American Psychiatric Association guidelines. High-quality evidence supports CBT with exposure and response prevention techniques as a first-line treatment for OCD. Protocols for Internet-delivered CBT have also proven efficacious for adults with OCD. Conclusion: High-quality scientific evidence supports the use of CBT with exposure and response prevention to treat adults with OCD.

Abstract In geometrically nonlinear problems solved using the Finite Element Method (FEM), the structure response is directly influenced by the level of discretization and the nonlinear solution algorithm used. To reduce the discretization dependence, exact solutions are developed based on the deformed infinitesimal element equilibrium. To deal with the nonlinear solution problem, the two-cycle method can be used, since it is not dependent on load or displacement steps. The two-cycle method developed by Chen & Lui (1991) uses the classical geometric matrix and is not accurate for high axial loads. This happens because the geometric matrix is obtained using Hermitian polynomials which are approximate solutions. To circumvent this issue, the frame element’s tangent matrix is obtained using interpolation functions that match the homogeneous solution of the differential equation of the beam-column problem. The main objective of this study is to carry out a second order analysis of the frames and obtain equilibrium paths using the two-cycle method and the tangent stiffness matrix based on solutions of the differential equations obtained from the element’s deformed configuration. The results in terms of displacements and rotations for the examples studied are identical to the analytical solutions, showing that the combination of the two-cycle method with the exact element formulation is promising and can diminish the need for discretization.

Objectives: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with selective serotonin reuptake inhibitors (SSRIs), clomipramine, serotonin and norepinephrine reuptake inhibitors (SNRIs), and augmentation strategies with clomipramine, antipsychotics, and glutamate-modulating agents. We searched for the literature published from 2013-2020 in five databases, considering the design of the study, primary outcome measures, types of publication, and language. Selected articles had their quality assessed with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA). Results: We examined 57 new studies to update the 2013 APA guidelines. High-quality evidence supports SSRIs for first-line pharmacological treatment of OCD. Moreover, augmentation of SSRIs with antipsychotics (risperidone, aripiprazole) is the most evidence-based pharmacological intervention for SSRI-resistant OCD. Conclusion: SSRIs, in the highest recommended or tolerable doses for 8-12 weeks, remain the first-line treatment for adult OCD. Optimal augmentation strategies for SSRI-resistant OCD include low doses of risperidone or aripiprazole. Pharmacological treatments considered ineffective or potentially harmful, such as monotherapy with antipsychotics or augmentation with ketamine, lamotrigine, or N-acetylcysteine, have also been detailed.

ABSTRACT Neoplasms of the biliopancreatic confluence may present with obstruction of the bile tract, leading to jaundice, pruritus and cholangitis. In these cases drainage of the bile tract is imperative. Endoscopic retrograde cholangiopancreatography (ERCP) with placement of a choledochal prosthesis is an effective treatment in about 90% of cases, even in experienced hands. In cases of ERCP failure, therapeutic options traditionally include surgical bypass by hepaticojejunostomy (HJ) or percutaneous transparietohepatic drainage (DPTH). In recent years, endoscopic ultrasound-guided biliary drainage techniques have gained space because they are less invasive, effective and have an acceptable incidence of complications. Endoscopic echo-guided drainage of the bile duct can be performed through the stomach (hepatogastrostomy), duodenum (choledochoduodenostomy) or by the anterograde drainage technique. Some services consider ultrasound-guided drainage of the bile duct the procedure of choice in the event of ERCP failure. The objective of this review is to present the main types of endoscopic ultrasound-guided biliary drainage and compare them with other techniques.

RESUMO Neoplasias da confluência biliopancreática podem cursar com obstrução da via biliar, levando a icterícia, prurido e colangite. Nesses casos a drenagem da via biliar é imperativa. A colangiopancreatografia endoscópica retrógrada (CPER) com colocação de prótese coledociana constitui tratamento eficaz em cerca de 90% dos casos mesmo em mãos experientes. Nos casos de insucesso da CPER, tradicionalmente as opções terapêuticas incluem a derivação cirúrgica por hepaticojejunostomia (HJ) ou drenagem percutânea transparietohepática (DPTH). Nos últimos anos as técnicas endoscópicas ecoguiadas de drenagem biliar ganharam espaço por serem menos invasivas, eficazes e apresentarem incidência aceitável de complicações. A drenagem endoscópica ecoguiada da via biliar pode ser realizada pelo estômago (hepatogastrostomia), duodeno (coledocoduodenostomia) ou pela técnica de drenagem anterógrada. Alguns serviços consideram a drenagem ecoguiada da via biliar o procedimento de escolha no caso de insucesso da CPER. O objetivo desta revisão é apresentar os principais tipos de drenagem biliar endoscópica ecoguiada e confrontá-los com outras técnicas.

ABSTRACT: This study discusses the epidemiological, clinical, and pathological characteristics of two outbreaks of ocular infection in ostriches (Struthio camelus) caused by the trematode Philophthalmus sp. The outbreaks occurred in the states of Ceará and Rio Grande do Norte in Northeast Brazil. Ostrich farming was categorized as semi-intensive farming with free access to the weir and river. The clinical symptoms for infection included nictitating membrane inflammation, epiphora (tearing), eyelid edema, ocular congestion, eyeball destruction, emaciation, and death, and the infection period ranged from 8 to 16 months. Macroscopically, thickening of the eyelids and conjunctiva were observed, with orange parasites infestation. Histologically, the lesions were characterized as lymphoplasmacytic and heterophilic, multifocal to coalescing, moderate, chronic conjunctivitis associated with hyperplasia and ectasia of the Harderian gland, and numerous parasites. The parasites were oval and flattened with an oral suction cup, acetabulum, and thick cuticle containing spicules. The diagnosis of philophthalmiasis was based on epidemiological, clinical, and pathological findings associated with the morphological characteristics of the parasites present in the conjunctival sacs which were similar to the trematode Philophthalmus sp. Philophthalmiasis can occur in ostriches raised on urban and rural properties in Northeastern Brazil, probably associated with the contact of birds with contaminated water, and is characterized by severe conjunctivitis that can result in the loss of the eyeball and death of the animals.

RESUMO: Descrevem-se as características epidemiológicas, clínicas e patológicas de dois surtos de infecção ocular pelo trematódeo Philophthalmus sp. em avestruzes ocorridos nos estados do Ceará e Rio Grande do Norte no Nordeste do Brasil. As propriedades tinham em comum, a criação semi-intensiva e livre acesso a açude e rio. Os sinais clínicos incluíam protrusão da membrana nictante, lacrimejamento, edema palpebral, congestão ocular, destruição do globo ocular, emagrecimento e morte. A evolução clínica variou de oito a 16 meses. Macroscopicamente, observou-se espessamento das pálpebras e conjuntivas associado a numerosas estruturas parasitárias alaranjadas. No segundo surto, as lesões eram mais graves e consistiam em perda do globo ocular direito e anexos. Histologicamente, as lesões caracterizavam-se por conjuntivite linfoplasmocítica e heterofílica, multifocal a coalescente, moderada, crônica associada a hiperplasia e ectasia da glândula de Harderian e numerosas estruturas parasitárias. Os parasitas eram ovalados, achatados com ventosa oral e acetábulo e cutícula espessa contendo espículas. O diagnóstico de filoftalmíase foi realizado com base nos achados epidemiológicos, clínicos e patológicos associadas as características morfológicas dos parasitas presentes nos sacos conjuntivais compatíveis com o trematódeo Philophthalmus sp. A filoftalmíase pode ocorrer em avestruzes criados em propriedades urbanas e rurais no Nordeste do Brasil, provavelmente associado ao contato das aves com água contaminada e caracteriza-se por quadros de conjuntivite grave que pode resultar com a perda do globo ocular e morte dos animais.

ABSTRACT Introduction: CrossFit was created to develop the physical and motor skills of athletes in all categories, aiming for the physical limit of everyone who practices it, in accordance with their toning capacity. Objectives: Considering that the quest for these limits has resulted in an increasing number of CrossFitter injuries, the objective of this study was to define the levels of pain and the anatomical regions affected among CrossFitters in the city of Alfenas. Methods: The Corlett diagram was used in association with the Visual Analog Scale, which ranges from 1 to 10. Three CrossFit gyms in the city of Alfenas were visited and their CrossFitters were invited to participate in this research. Those who agreed to participate (109) signed the informed consent form. Results: Of the total number of participants interviewed, 86.63% reported having some type of pain in their daily CrossFit routine. Of the total number of respondents who experienced pain, 56.68% were women and 43.32% were men. The three areas that stand out with the highest prevalence of pain were shoulders at 51.37%, the lower back at 44.03%, and the knees at 40.36%. The One-way ANOVA test was applied with p≤ 0.05 and there was no statistical difference between the pain groups (trunk pain, right limb pain, and left limb pain). Conclusion: When we applied the Corlett diagram to verify the degree and anatomical regions of pain in CrossFitters in the city of Alfenas, it was evident that CrossFit is a sport that, by demanding a lot from those who practice it, ends up causing moderate to severe pain, especially in the shoulder, lumbar, and knee regions. Level of evidence II; Retrospective study.

RESUMEN Introducción: El CrossFit fue creado para desarrollar las habilidades físicas y motoras de deportistas de todas las categorías, apuntando al límite físico de cada practicante, según su capacidad tónica. Objetivos: Considerando que la búsqueda de estos límites ha resultado en cada vez más lesiones en sus practicantes, este estudio tuvo como objetivo establecer el grado de dolor y la región anatómica afectada resultante del CrossFit en la ciudad de Alfenas. Métodos: Para ello, se utilizó el diagrama de Corlett asociado a la Escala Visual Analógica, que varía de 0 a 10. Se visitaron tres gimnasios de CrossFit en la Ciudad de Alfenas y se invitó a los frecuentadores a participar en esta investigación y todos los que aceptaron participar (109) firmaron el formulario de consentimiento informado. Resultados: Del total de encuestados, el 86,63% informó tener algún tipo de dolor en la práctica diaria de CrossFit. Del total de encuestados que presentaron dolor, el 56,68% eran mujeres y el 43,32% hombres. Entre los tres lugares de mayor prevalencia de dolor, se destacaron los hombros, 51,37%; espalda baja, 44,03% y rodilla, 40,36%. Se aplicó la prueba ANOVA One Way con p≤ 0,05 y no hubo diferencias estadísticas entre los grupos de dolor (dolor de tronco, dolor de miembro derecho y dolor de miembro izquierdo). Conclusión: Al aplicar el diagrama de Corlett para verificar el grado de dolor y la región anatómica en los practicantes de CrossFit en la ciudad de Alfenas, se evidenció que CrossFit es un deporte que, al exigir mucho a sus practicantes, termina provocando dolor moderado a severo, especialmente en las regiones del hombro, la espalda baja y la rodilla. Nivel de evidencia II; Estudio retrospectivo.

RESUMO Introdução: O CrossFit foi criado para desenvolver as habilidades físicas e motoras de atletas de todas as categorias, visando o limite físico de cada praticante, de acordo com sua capacidade tônica. Objetivos: Considerando que a busca desses limites tem acarretado cada vez mais lesões nos praticantes, este estudo visou estabelecer o grau de dor e a região anatômica afetada decorrentes do CrossFit na cidade de Alfenas. Métodos: Para tal, foi usado o diagrama de Corlett associado à Escala Visual Analógica, que varia de 0 a 10. Três academias de CrossFit da cidade de Alfenas foram visitadas e os frequentadores foram convidados a participar desta pesquisa e todos que concordaram em participar (109) assinaram o termo de consentimento livre esclarecido. Resultados: Do total de entrevistados, 86,63% relataram ter algum tipo de dor na prática diária de CrossFit. Do total de entrevistados que apresentaram dor, 56,68% eram mulheres e 43,32% homens. Entre os três locais de maior prevalência de dor destacaram-se ombros, 51,37%; parte inferior das costas/do dorso, 44,03%; joelho, 40,36%. Foi aplicado o teste ANOVA One Way com p ≤ 0,05 e não houve diferença estatística entre os grupos de dor (dor no tronco, dor no membro direito e dor no membro esquerdo). Conclusão: Ao aplicar o diagrama de Corlett para verificar o grau de dor e a região anatômica nos praticantes de CrossFit da cidade de Alfenas, evidenciou-se que o CrossFit é um esporte que, por exigir muito dos praticantes, acaba acarretando dores de moderada a grave, principalmente nas regiões do ombro, lombar e do joelho. Nível de evidência II; Estudo retrospectivo.

Abstract Objectives Evidence suggests that ketamine’s influence on brain-derived neurotrophic factor (BDNF) might be involved in its mechanism of rapid antidepressant action. We aimed to evaluate the differential impact of ketamine and esketamine on serum BDNF levels and its association with response patterns in treatment-resistant depression (TRD). Methods Participants (n = 53) are from a randomized, double-blind clinical trial comparing the efficacy of single-dose ketamine (0.5mg/kg, n = 27) and esketamine (0.25mg/kg, n = 26) in TRD. Depression severity was assessed before and 24 hours, 72 hours, and 7 days after the intervention, using the Montgomery-Åsberg Depression Rating Scale (MADRS). Blood samples were collected before infusion, 24 hours, and 7 days afterwards. Results There were no significant changes in BDNF levels at post-infusion evaluation points, and no difference in BDNF levels comparing ketamine and esketamine. Both drugs exhibited similar therapeutic effect. There was no association between BDNF levels and response to treatment or severity of depressive symptoms. Conclusion There was no significant treatment impact on BDNF serum levels – neither with ketamine nor esketamine – despite therapeutic response. These results suggest that ketamine or esketamine intervention for TRD has no impact on BDNF levels measured at 24 hours and 7 days after the infusion. This clinical trial is registered on the Japan Primary Registries Network: UMIN000032355.

ABSTRACT Objective: Review the studies that investigated coping in soccer. Methods: A systemic search was carried out in the following databases: Pubmed, Web of Science, Scielo, Scopus, PsychINFO and SPORTDiscus. The descriptors related to the terms (Coping skills, Sport and Football) were verified in the MeSH (Medical Subject Headings) database. The inclusion criteria used were: Empirical studies published in journals peer-reviewed scientific papers; b) Studies published from December 2014 to December 2019; c) with at least one quantitative measure; d) Studies with samples of soccer athletes; and e) Articles with specific reference to the topic 'Coping skills'. Results: The results showed that coping skills interact with important variables for good performance in elite soccer, such as competitive level, sports talent, psychopathologies, age group and sex. More specifically, it was noted that the development of some coping strategies, such as facing adversity, trust/motivation and performance under pressure, are potentially common to these variables. Conclusion: It is concluded that the development of some coping strategies is fundamental to the elite athlete, since it is positively associated with the optimal development of most of the variables analyzed in the synthesized studies.

RESUMO Objetivo: Revisar sistematicamente os estudos que investigaram o coping no futebol. Métodos: Foi realizada busca sistêmica nas seguintes bases de dados: Pubmed, Web of Science, Scielo, Scopus, PsychINFO e SPORTDiscus. Os descritores relacionados aos termos (Habilidades de enfrentamento, Esporte e Futebol) foram verificados na base de dados MeSH (Medical Subject Headings). Os critérios de inclusão utilizados foram: Estudos empíricos publicados em periódicos artigos científicos revisados por pares; b) Estudos publicados de dezembro de 2014 a dezembro de 2019; c) com pelo menos uma medida quantitativa; d) Estudos com amostras de atletas de futebol; e e) Artigos com referência específica ao tema 'Habilidades de enfrentamento'. Resultados: Os resultados mostraram que as habilidades de enfrentamento interagem com variáveis importantes para o bom desempenho no futebol de elite, como nível competitivo, talento esportivo, psicopatologias, faixa etária e sexo. Mais especificamente, notou-se que o desenvolvimento de algumas estratégias de enfrentamento, como enfrentar adversidades, confiança/motivação e desempenho sob pressão, são potencialmente comuns a essas variáveis. Conclusão: Conclui-se que o desenvolvimento de algumas estratégias de enfrentamento é fundamental para o atleta de elite, pois está positivamente associado ao desenvolvimento ótimo da maioria das variáveis analisadas nos estudos sintetizados.

Cancer treatment represents one of the main scientific study targets today, mainly due to the pronounced side effects arising from chemotherapy. This study reports the synthesis, characterization, and anticancer activity of ten compounds from the Morita-Baylis-Hillman reaction. Ethylene glycol diacrylate was used as a double Michael acceptor in reactions with isatin derivatives to give homodimers of 3-hydroxyindolin-2-one core, recognized in the literature for its extensive pharmacological profile. The use of 1,4-diazabicyclo[2,2,2]octane (DABCO) as a catalyst and room temperature were the optimal conditions for the study reaction. The isolated yields were up to 63%, with most reaction times inferior to 24 h, some as fast as 15 min. The anticancer potential of the synthesized dimers was evaluated in vitro against three cancer strains, resulting in average inhibitory concentrations up to 0.72 µM. It was also found that the best performing homodimers are more active than their monomeric counterparts. Considering the promising selectivity indices observed, the preliminary results obtained here act as a basis for broader tests regarding the effectiveness of homodimeric adducts against cancer cells.

Abstract The objective of this work was to evaluate the effects of additives and storage time on the quality and aerobic deterioration of silages of pineapple crop waste. A completely randomized design was used, in a 3×3 factorial arrangement, with three treatments: pineapple waste silage without additives or with the addition of cornmeal or wheat bran (20% fresh matter) at three storage times (60, 90, and 120 days). After each storage time, losses and aerobic deterioration were quantified, chemical composition was analyzed, and digestibility assays were performed. The storage time of 120 days resulted in higher dry matter losses in all treatments. The additives incremented the dry matter contents of the pineapple-based silages, which went from 182.1 g kg−1 (control silage) to 298.7 and 297.6 g kg−1 (cornmeal and wheat bran, respectively). The control silage with the addition of cornmeal showed the highest dry matter digestibility (739.7 g kg−1) and lowest neutral detergent fiber content (251.9 g kg−1). The production of CO2 started to increase on the first day of air exposure in silages without additives, but only after six days in those with additives. Including cornmeal as an additive in the silage of pineapple crop waste improves its digestibility and reduces its deterioration speed.

Resumo O objetivo deste trabalho foi avaliar os efeitos de aditivos e tempos de armazenamento sobre a qualidade e a deterioração aeróbia de silagens de resíduos de cultura do abacaxi. Utilizou-se um delineamento inteiramente casualizado, em arranjo fatorial 3×3, com três tratamentos: silagem de resíduos culturais de abacaxi sem aditivo ou aditivada com fubá de milho ou farelo de trigo (20% da matéria fresca), em três tempos de armazenamento (60, 90 e 120 dias). Após cada tempo de armazenamento, realizaram-se quantificações de perdas e deterioração aeróbia, análises da composição química e ensaios de digestibilidade. O tempo de armazenamento por 120 dias resultou em maiores perdas de matéria seca em todos os tratamentos. Os aditivos incrementaram os teores de matéria seca das silagens à base de abacaxi, que passaram de 182,1 g kg−1 (silagem controle) para 298,7 e 297,6 g kg−1 (fubá de milho e farelo de trigo, respectivamente). A silagem controle adicionada de fubá de milho apresentou maior digestibilidade da matéria seca (739,7 g kg−1) e menor teor de fibra em detergente neutro (251,9 g kg−1). A produção de CO2 aumentou a partir do primeiro dia de exposição ao ar nas silagens não aditivadas, mas apenas a partir do sexto dia nas aditivadas. A inclusão do fubá de milho como aditivo na silagem de resíduos de abacaxi melhora sua digestibilidade e reduz sua velocidade de deterioração.

Abstract The impact of the Antarctic Ozone Hole Influence over Southern Brazil in October 2015 was analyzed using daily mean data of the Total Column Ozone (TCO), Ultraviolet Index (UVI) and Radiative Cloud Fraction (RCF) from the Ozone Monitoring Instrument satellite instrument. Vertical profiles and fields of ozone content and Potential Vorticity available from the European Centre for Medium-Range Weather Forecast reanalysis, air masses backward trajectories from the HYbrid Single-Particle Lagrangian Integrated Trajectory model and channel 3 water vapor images from the Geostationary Operational Environmental Satellite GOES-13 were also analyzed. The five identified events showed an -7.4±2.3% average TCO reduction, leading to an +16.6±54.6% UVI increase even with a predominance of partly cloudy days. Other impacts were observed in the ozone profiles, where the most significant anomalies occurred from 650 K reaching 1.2 ppmv at the 850 K level. In the ozone fields at 700 K, the presence of a polar origin tongue was observed causing negatives anomalies between -0.2 and 0.4 ppmv in a transient system format forced with eastward-traveling Rossby waves passing through the Southern of Brazil and Uruguay.

ABSTRACT Objective: to examine the interprofessional education elements present in the integrated curricula of the Multiprofessional Residency Programs in Health in the cities from inland Rio Grande do Norte. Method: a documentary research study based on the analysis of three Pedagogical Course Projects with a quantitative approach. The data were extracted with the aid of an adapted instrument, processed in the Iramuteq software, presented in charts and in a dendrogram and analyzed by thematic categories and interpretively. Results: the text corpus was built from the organization of all the information through the adapted instrument and subsequently analyzed in Iramuteq through Descending Hierarchical Classification. The emergence of two main classes was identified: Class 3, which was subdivided into classes 1 and 2; and Class 4. From the keywords found in the dendrogram corresponding to each Class and their statistical similarity, it was possible to organize the classes into analysis categories, as follows: Class 3 - Interprofessional Education: Actors, contexts and strategies; and Class 4 - Methodological and evaluative strategies for building interprofessional competencies and skills. Through the Pedagogical Course Projects, a training process that values the development of competencies for teamwork, interprofessional and comprehensive care is indicated, based on the guiding principles of interprofessional education. Conclusion: there is an effort by the pedagogical projects to point to an integrated curriculum based on Interprofessional Education since, in their theoretical framework, they contribute fundamental principles for developing the teaching-learning process.

RESUMEN Objetivo: examinar los elementos de la educación interprofesional presentes en los planes de estudios integrados de los Programas de Residencia Multiprofesionales en Salud en las ciudades del interior do Rio Grande do Norte. Método: investigación documental a partir del análisis de tres Proyectos Pedagógicos de Carreras Universitarias con enfoque cuantitativo. Los datos se extrajeron con la ayuda de un instrumento adaptado, se los procesó en el programa de software Iramuteq, se presentaron en forma de cuadros y de dendrograma y se los analizó por categorías temáticas y en forma interpretativa. Resultados: el corpus de texto se elaboró a partir de organizar toda la información en el instrumento adaptado e, inmediatamente después, se lo analizó en Iramuteq por medio de Clasificación Jerárquica Descendente. Se identificaron dos clases principales: a Clase 3, que se subdividió en las clases 1 y 2; y Clase 4. A partir de las palabras clave presentes en el dendrograma de cada Clase y su similitud estadística, fue posible organizar las clases en categorías de análisis, a saber: Clase 3 - Educación interprofesional: Actores, contextos y estrategias; y Clase 4 - Estrategias metodológicas y evaluativas para desarrollar competencias y habilidades interprofesionales. A través de los Proyectos Pedagógicos de Carreras Universitarias, se señala un proceso formativo que valoriza el desarrollo de competencias para trabajo en equipo, interprofesional y cuidado integral, a partir de principios guía de la educación interprofesional. Conclusión: los proyectos pedagógicos se esfuerzan por indicar el camino a un plan de estudios integrado y fundamentado en la Educación Interprofesional, puesto que incluyen principios fundamentales para desarrollar el proceso de en enseñanza-aprendizaje en su marco teórico.

RESUMO Objetivo: examinar os elementos da educação interprofissional presentes nos currículos integrados das Residências Multiprofissionais em Saúde nas cidades do interior do Rio Grande do Norte. Método: pesquisa documental a partir da análise de três Projetos Pedagógicos de Curso com abordagem quantitativa. Os dados foram coletados de novembro de 2022 a janeiro de 2023 e extraídos com auxílio de um instrumento adaptado, processados no software Iramuteq, apresentados em quadros, dendograma e analisados por categorias temáticas e interpretativamente. Resultados: o corpus textual foi construído a partir da organização das informações através do instrumento adaptado e, logo após, analisado no Iramuteq por meio de Classificação Hierárquica Descendente. Identificou-se o surgimento de duas classes principais: a Classe 3, que se subdividiu em classe 1 e 2; e a Classe 4. A partir das palavras-chaves presentes no dendrograma de cada Classe e sua similaridade estatística, foi possível organizar as classes em categorias de análises, sendo: Classe 3 - Educação interprofissional: Atores, contextos e estratégias; e Classe 4 - Estratégias metodológicas e avaliativas para a construção de competências e habilidades interprofissionais. Indica-se, através dos Projetos Pedagógicos de Curso, um processo formativo que valoriza a construção de competências para um trabalho em equipe, interprofissional e cuidado integral, a partir de princípios norteadores da educação interprofissional. Conclusão: há um esforço dos projetos pedagógicos em apontar para um currículo integrado fundamentado em Educação Interprofissional, visto que trazem, em seu arcabouço teórico, princípios fundamentais para o desenvolvimento do processo ensino-aprendizagem.

ABSTRACT Objective: To describe the effects of balanced solution use on the short-term outcomes of patients with traumatic brain injury enrolled in BaSICS trial. Methods: Patients were randomized to receive either 0.9% saline or balanced solution during their intensive care unit stay. The primary endpoint was 90-day mortality, and the secondary outcomes were days alive and free of intensive care unit stay at 28 days. The primary endpoint was assessed using Bayesian logistic regression. The secondary endpoint was assessed using a Bayesian zero-inflated beta binomial regression. Results: We included 483 patients (236 in the 0.9% saline arm and 247 in the balanced solution arm). A total of 338 patients (70%) with a Glasgow coma scale score ≤ 12 were enrolled. The overall probability that balanced solutions were associated with higher 90-day mortality was 0.98 (OR 1.48; 95%CrI 1.04 - 2.09); this mortality increment was particularly noticeable in patients with a Glasgow coma scale score below 6 at enrollment (probability of harm of 0.99). Balanced solutions were associated with -1.64 days alive and free of intensive care unit at 28 days (95%CrI -3.32 - 0.00) with a probability of harm of 0.97. Conclusion: There was a high probability that balanced solutions were associated with high 90-day mortality and fewer days alive and free of intensive care units at 28 days. ClinicalTrials.gov:NCT02875873

RESUMO Objetivo: Descrever os efeitos do uso de soluções balanceadas nos desfechos de curto prazo de pacientes com traumatismo craniencefálico incluídos no estudo BaSICS. Métodos: Os pacientes foram randomizados para receber solução salina 0,9% ou solução balanceada durante a internação em unidade de terapia intensiva. O desfecho primário foi mortalidade em 90 dias, já os desfechos secundários foram dias de vida e sem internação em unidade de terapia intensiva aos 28 dias. O desfecho primário foi avaliado por regressão logística bayesiana. O desfecho secundário foi avaliado usando regressão beta-binomial inflada de zeros bayesiana. Resultados: Incluímos 483 pacientes (236 no braço de solução salina 0,9% e 247 no braço de solução balanceada). Foram incluídos 338 pacientes (70%) com pontuação na escala de coma de Glasgow ≤ 12. A probabilidade geral de que soluções balanceadas estivessem associadas a maior mortalidade em 90 dias foi de 0,98 (RC de 1,48; ICr95% 1,04 - 2,09). Esse aumento de mortalidade foi particularmente perceptível em pacientes com pontuação na escala de coma de Glasgow abaixo de 6 no momento da inclusão (probabilidade de dano de 0,99). Soluções balanceadas foram associadas a -1,64 dia de vida e sem internação em unidade de terapia intensiva aos 28 dias (ICr95% -3,32 - 0,00) com probabilidade de dano de 0,97. Conclusão: Houve alta probabilidade de que soluções balanceadas estivessem associadas a alta mortalidade em 90 dias, menos dias de vida e sem internação em unidade de terapia intensiva aos 28 dias. ClinicalTrials.gov:NCT02875873