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Synthesis of 4-(4-chlorophenyl)thiazole compounds: in silico and in vitro evaluations as leishmanicidal and trypanocidal agents
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CRUZ FILHO, IRANILDO JOSÉ DA

; OLIVEIRA, JAMERSON F. DE

; SANTOS, ALINE CAROLINE S.

; PEREIRA, VALÉRIA R.A.

; LIMA, MARIA CARMO A. DE

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Nº 1 elocation e20220538

Resumo: En | Texto: En | PDF: En

Abstract Neglected tropical diseases are a diverse group of communicable pathologies that mainly prevail in tropical and subtropical regions. Thus, the objective of this work was to evaluate the biological potential of eight 4-(4-chlorophenyl)thiazole compounds. Tests were carried out in silico to evaluate the pharmacokinetic properties, the antioxidant, cytotoxic activities in animal cells and antiparasitic activities were evaluated against the different forms of Leishmania amazonensis and Trypanosoma cruzi in vitro. The in silico study showed that the evaluated compounds showed good oral availability. In a preliminary in vitro study, the compounds showed moderate to low antioxidant activity. Cytotoxicity assays show that the compounds showed moderate to low toxicity. In relation to leishmanicidal activity, the compounds presented IC50 values that ranged from 19.86 to 200 µM for the promastigote form, while for the amastigote forms, IC50 ranged from 101 to more than 200 µM. The compounds showed better results against the forms of T. cruzi with IC50 ranging from 1.67 to 100 µM for the trypomastigote form and 1.96 to values greater than 200 µM for the amastigote form. This study showed that thiazole compounds can be used as future antiparasitic agents.

https://doi.org/10.1590/0001-3765202320220538

Calcium pyruvate as a salt stress mitigator in yellow passion fruit seedlings
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Silva, Francisco de A. da

; Dias, Mirandy dos S.

; Fernandes, Pedro D.

; Lacerda, Cassiano N. de

; Silva, André A. R. da

; Marcelino, Aline D. A. de L.

; Lima, Andrezza M. de

; Barbosa, Daniela D.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Nov 2022, Volume 26 Nº 11 Páginas 763 - 770

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Embora a região semiárida do Nordeste brasileiro seja uma grande produtora de maracujá amarelo, os problemas de sais no solo e nas fontes hídricas, em muitas áreas, têm limitado o crescimento e a produção dessa cultura, o que realça a importância de estudos visando a reduzir tais efeitos. Nesse contexto, objetivou-se com este estudo, avaliar o efeito da aplicação foliar de piruvato, como mitigador do estresse salino, sobre a morfofisiologia do maracujazeiro cv. Redondo Amarelo, em fase de mudas. Os tratamentos constaram de três condutividades elétricas da água de irrigação (CEa: 0,8, 2,4 e 4,0 dS m-1) e três concentrações de piruvato (0, 25 e 50 mM), distribuídos em delineamento experimental de blocos casualizados, em esquema fatorial 3 × 3, com quatro repetições e duas plantas por parcela. A irrigação com águas de CEa de 4,0 dS m-1 reduz as variáveis de crescimento, fitomassa, indice de qualidade de Dickson e aumenta o extravasamento de eletrólitos em mudas de maracujazeiro cv. Redondo Amarelo. A aplicação exógena de piruvato de cálcio (25 e 50 mM) favorece as variáveis de crescimento, fitomassa, indice de qualidade de Dickson, teor relativo de água, suculência foliar e reduz o extravasamento de eletrólitos no limbo foliar do maracujá. A aplicação exógena de piruvato atenua o estresse salino, com efeitos benéficos na taxa de assimilação de CO2, transpiração, eficiência da carboxilação instantânea, eficiência intrínseca do uso da água e massa seca das raízes.

ABSTRACT Although the semi-arid region of Northeast Brazil is a major producer of yellow passion fruit, the problems of salts in the soil and water sources, in many areas have limited the growth and production of this crop, which highlights the importance of studies aimed at reducing such effects. In this context, the objective of this study was to evaluate the effect of foliar application of pyruvate, as a mitigator of salt stress, on the morphophysiology of yellow passion fruit, in seedling phase. The treatments consisted of three electrical conductivities of irrigation water (ECw: 0.8, 2.4, and 4.0 dS m-1) and three concentrations of pyruvate (0, 25, and 50 mM), distributed in a randomized block experimental design in a 3 × 3 factorial scheme, with four replications and two plants per plot. Irrigation with ECw of 4.0 dS m-1 reduces growth variables, phytomass, Dickson quality index, and increases electrolyte leakage in passion fruit seedlings cv. Redondo Amarelo. Exogenous application of calcium pyruvate (25 and 50 mM) increased growth, phytomass, Dickson quality index, relative water content and leaf succulence and reduced electrolyte leakage in the leaf blade in passion fruit. Exogenous application of pyruvate attenuates salt stress, with beneficial effects on CO2 assimilation rate, transpiration, instantaneous carboxylation efficiency, intrinsic water use efficiency, and root dry mass.

https://doi.org/10.1590/1807-1929/agriambi.v26n11p763-770

Antarctic environments as a source of bacterial and fungal therapeutic enzymes
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LIMA, IGOR G.O.

; BISPO, JAMES R.S.

; AGOSTINHO, ADSON Y.H.

; QUEIROZ, ALINE C. DE

; MOREIRA, MAGNA SUZANA A.

; PASSARINI, MICHEL RODRIGO Z.

; OLIVEIRA, VALÉRIA M. DE

; SETTE, LARA D.

; ROSA, LUIZ HENRIQUE

; DUARTE, ALYSSON WAGNER F.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Supl. 1 elocation e20210452

Resumo: En | Texto: En | PDF: En

Abstract Microbial therapeutic enzymes are the protagonists in the pharmacological treatment of different human diseases. The intrinsic enzymatic characteristics, such as high affinity and specificity to the corresponding substrate, enable effective therapies, with minimal adverse effects and complete remission. However, immunogenicity, short half-life, low enzymatic yield, and low selectivity regarding available enzyme drugs are currently the main obstacles to their development and the broad adherence to therapeutic protocols. By harboring adapted and still unexplored microbial life, environments of extreme conditions, such as Antarctica, become especially important in the prospecting and development of new enzymatic compounds that present higher yields and the possibility of genetic improvement. Antarctic microorganisms have adaptation mechanisms, such as more fluid cell membranes, production of antifreeze proteins and enzymes with more malleable structures, more robust, stable, selective catalytic sites for their respective substrates, and high antioxidant capacity. In this context, this review aims to explore enzymes synthesized by bacteria and fungi from Antarctica as potential drug producers, capable of providing therapeutic efficacy, less adverse effects, and lower production costs with highlight to L-Asparaginase, collagenase, superoxide dismutase and ribonucleases. In addition, this review highlights the unique biotechnological profile of these Antarctic extremophile microorganisms.

https://doi.org/10.1590/0001-3765202220210452

Marine fish and benthic biota before the 2019 oil spill: A baseline dataset for monitoring programs and impact assessments at Rio Grande Norte state, Northeastern Brazil
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VIANA, MARINA G.

; LIMA, MAURO S.P.

; MARTINEZ, ALINE S.

; BARBOZA, ALINA R.P.

; MELO, CLARA, S.

; CALADO, JANAÍNA F.

; GRIMALDI, GUIDO G.

; SOUZA, THAISA A.

; LEITE, TATIANA S.

; MENDES, LIANA F.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 elocation e20210536

Resumo: En | Texto: En | PDF: En

Abstract In 2019 an oil spill spread over more than 4000 km of the Brazilian coastline. Monitoring programs that allow for the evaluation of potential impacts on communities and ecosystems and their recovery through time are needed and rely on baseline information previous to the oil spill. Here we compiled qualitative and quantitative data available from 8 studies on fish and benthic species from different habitats of Rio Grande do Norte (RN) from 2007 to 2018. We assessed the number of species from different locations and compiled information on conservation status and human use. We mapped the study areas and habitats and overlapped them with those affected by the oil spill. The RN state has a high diversity of fish (175 species) and benthic species (285 species), of which more than half of fish (52%) and 2% of benthic species are threatened and 72,8% of fish and 7,9% of benthic species are of commercial interest. Information of most habitats is still poorly known (i.e.majority ofthe available data are from unique and punctual sampling), which may weaken future evaluations of the real impact of the oil spill. Nonetheless, it is possible to design reliable monitoring based on our dataset, persistent contamination and future loss of diversity.

https://doi.org/10.1590/0001-3765202120210536

Differentials in death count records by databases in Brazil in 2010
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Diógenes, Victor Hugo Dias

; Pinto Júnior, Elzo Pereira

; Gonzaga, Marcos Roberto

; Queiroz, Bernardo Lanza

; Lima, Everton E. C.

; Costa, Lilia Carolina C. da

; Rocha, Aline S.

; Ferreira, Andrêa J. F.

; Teixeira, Camila S. S.

; Alves, Flávia Jôse O.

; Rameh, Leila

; Flores-Ortiz, Renzo

; Leyland, Alastair

; Dundas, Ruth

; Barreto, Maurício L.

; Ichihara, Maria Yury Travassos

Revista de Saúde Pública

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2022, Volume 56 elocation 92

Resumo: En | Texto: En | PDF: En

ABSTRACT OBJECTIVE To compare the death counts from three sources of information on mortality available in Brazil in 2010, the Mortality Information System (SIM - Sistema de Informações sobre Mortalidade ), Civil Registration Statistic System (RC - Sistema de Estatísticas de Resgistro Civil ), and the 2010 Demographic Census at various geographical levels, and to confirm the association between municipal socioeconomic characteristics and the source which showed the highest death count. METHODS This is a descriptive and comparative study of raw data on deaths in the SIM, RC and 2010 Census databases, the latter held in Brazilian states and municipalities between August 2009 and July 2010. The percentage of municipalities was confirmed by the database showing the highest death count. The association between the source of the highest death count and socioeconomic indicators - the Índice de Privação Brasileiro (IBP – Brazilian Deprivation Index) and Índice de Desenvolvimento Humano Municipal (IHDM – Municipal Human Development Index) - was performed by bivariate choropleth and Moran Local Index of Spatial Association (LISA) cluster maps. RESULTS Confirmed that the SIM is the database with the highest number of deaths counted for all Brazilian macroregions, except the North, in which the highest coverage was from the 2010 Census. Based on the indicators proposed, in general, the Census showed a higher coverage of deaths than the SIM and the RC in the most deprived (highest IBP values) and less developed municipalities (lowest IDHM values) in the country. CONCLUSION The results highlight regional inequalities in how the databases chosen for this study cover death records, and the importance of maintaining the issue of mortality on the basic census questionnaire.

https://doi.org/10.11606/s1518-8787.2022056004282

Differentials in death count records by databases in Brazil in 2010
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Diógenes, Victor Hugo Dias

; Pinto Júnior, Elzo Pereira

; Gonzaga, Marcos Roberto

; Queiroz, Bernardo Lanza

; Lima, Everton E. C.

; Costa, Lilia Carolina C. da

; Rocha, Aline S.

; Ferreira, Andrêa J. F.

; Teixeira, Camila S. S.

; Alves, Flávia Jôse O.

; Rameh, Leila

; Flores-Ortiz, Renzo

; Leyland, Alastair

; Dundas, Ruth

; Barreto, Maurício L.

; Ichihara, Maria Yury Travassos

Revista de Saúde Pública

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2022, Volume 56 elocation 92

Resumo: En | Texto: En | PDF: En

https://doi.org/10.11606/s1518-8787.2022056004282

Associação entre Terapia com Estatinas e Menor Incidência de Hiperglicemia em Pacientes Internados com Síndromes Coronarianas Agudas
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Furtado, Remo Holanda de Mendonça

; Genestreti, Paulo Rizzo

; Dalçóquio, Talia F.

; Baracioli, Luciano Moreira

; Lima, Felipe Galego

; Franci, André

; Giraldez, Roberto R. C. V.

; Menezes, Fernando R.

; Ferrari, Aline Gehlen

; Lima, Viviane Moreira

; Pereira, Cesar A. C.

; Nakashima, Carlos Alberto Kenji

; Salsoso, Rocio

; Godoy, Lucas Colombo

; Nicolau, José C.

Arquivos Brasileiros de Cardiologia

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Fev 2021, Volume 116 Nº 2 Páginas 285 - 294

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento O maior risco de se desenvolver diabetes com o uso de estatinas é um desafio para a segurança do uso dessa classe de medicamentos em longo prazo. No entanto, poucos estudos analisaram essa questão durante síndromes coronarianas agudas (SCA). Objetivos Investigar a associação entre início precoce da terapia com estatina e níveis de glicemia em pacientes admitidos com SCA. Métodos Este foi um estudo retrospectivo de pacientes hospitalizados por SCA. Pacientes que nunca haviam usado estatinas foram incluídos e divididos segundo uso ou não de estatina nas primeiras 24 horas de internação. O desfecho primário foi a incidência de hiperglicemia na internação (definida como pico de glicemia > 200mg/dL). Modelos de regressão logística e modelos lineares multivariados foram usados para ajuste quanto a fatores de confusão e um modelo de pareamento por escore de propensão foi desenvolvido para comparações entre os dois grupos de interesses. Um valor de p menor que 0,05 foi considerado estatisticamente significativo. Resultados Um total de 2357 pacientes foram incluídos, 1704 deles alocados no grupo que receberam estatinas e 653 no grupo que não receberam estatinas nas primeiras 24 horas de internação. Após os ajustes, uso de estatina nas primeiras 24 horas foi associado com uma menor incidência de hiperglicemia durante a internação (OR ajustado = 0,61, IC95% 0,46-0,80; p < 0,001) e menor necessidade de uso de insulina (OR ajustado = 0,56, IC 95% 0,41-0,76; p < 0,001). Essas associações mantiveram-se similares nos modelos de pareamento por escore de propensão, bem como após análises de sensibilidade, como exclusão de pacientes que desenvolveram choque cardiogênico, infecção grave ou pacientes que foram a óbito durante a internação hospitalar. Conclusões Entre os pacientes internados com SCA que não receberam estatinas previamente, a terapia precoce com estatina associou-se independentemente com menor incidência de hiperglicemia durante a internação. (Arq Bras Cardiol. 2021; 116(2):285-294)

Abstract Background Increased risk of new-onset diabetes with statins challenges the long-term safety of this drug class. However, few reports have analyzed this issue during acute coronary syndromes (ACS). Objective To explore the association between early initiation of statin therapy and blood glucose levels in patients admitted with ACS. Methods This was a retrospective analysis of patients hospitalized with ACS. Statin-naïve patients were included and divided according to their use or not of statins within the first 24 hours of hospitalization. The primary endpoint was incidence of in-hospital hyperglycemia (defined as peak blood glucose > 200 mg/dL). Multivariable linear and logistic regression models were used to adjust for confounders, and a propensity-score matching model was developed to further compare both groups of interest. A p-value of less than 0.05 was considered statistically significant. Results A total of 2,357 patients were included, 1,704 of them allocated in the statin group and 653 in the non-statin group. After adjustments, statin use in the first 24 hours was associated with a lower incidence of in-hospital hyperglycemia (adjusted OR=0.61, 95% CI 0.46-0.80; p < 0.001) and lower need for insulin therapy (adjusted OR = 0.56, 95% CI 0.41-0.76; p < 0.001). These associations remained similar in the propensity-score matching models, as well as after several sensitivity analyses, such as after excluding patients who developed cardiogenic shock, severe infection or who died during index-hospitalization. Conclusions Among statin-naïve patients admitted with ACS, early statin therapy was independently associated with lower incidence of in-hospital hyperglycemia. (Arq Bras Cardiol. 2021; 116(2):285-294)

https://doi.org/10.36660/abc.20200128 548 downloads

Factors associated with actively working in the very long-term following acute coronary syndrome
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Nicolau, Jose C.

; Furtado, Remo H.M.

; Dalçóquio, Talia F.

; Lara, Livia M.

; Juliasz, Marcela G.

; Ferrari, Aline G.

; Nakashima, Carlos A.K.

; Franci, Andre

; Pereira, Cesar A.C.

; Lima, Felipe G.

; Giraldez, Roberto R.

; Salsoso, Rocío

; Baracioli, Luciano M.

; Goodman, Shaun

Clinics

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2021, Volume 76 elocation e2553

Resumo: En | Texto: En | PDF: En

OBJECTIVES: Returning to work after an episode of acute coronary syndrome (ACS) is challenging for many patients, and has both personal and social impacts. There are limited data regarding the working status in the very long-term after ACS. METHODS: We retrospectively analyzed 1,632 patients who were working prior to hospitalization for ACS in a quaternary hospital and were followed-up for up to 17 years. Adjusted models were developed to analyze the variables independently associated with actively working at the last contact, and a prognostic predictive index for not working at follow-up was developed. RESULTS: The following variables were significantly and independently associated with actively working at the last contact: age>median (hazard-ratio [HR], 0.76, p<0.001); male sex (HR, 1.52, p<0.001); government health insurance (HR, 1.36, p<0.001); history of angina (HR, 0.69, p<0.001) or myocardial infarction (MI) (HR, 0.76, p=0.005); smoking (HR, 0.81, p=0.015); ST-elevation MI (HR, 0.81, p=0.021); anterior-wall MI (HR, 0.75, p=0.001); non-primary percutaneous coronary intervention (PCI) (HR, 0.77, p=0.002); fibrinolysis (HR, 0.61, p<0.001); cardiogenic shock (HR, 0.60, p=0.023); statin (HR, 3.01, p<0.001), beta-blocker (HR, 1.26, p=0.020), angiotensin-converting enzyme (ACE) inhibitor/angiotensin II receptor blocker (ARB) (HR, 1.37, p=0.001) at hospital discharge; and MI at follow-up (HR, 0.72, p=0.001). The probability of not working at the last contact ranged from 24.2% for patients with no variables, up to 80% for patients with six or more variables. CONCLUSIONS: In patients discharged after ACS, prior and in-hospital clinical variables, as well as the quality of care at discharge, have a great impact on the long-term probability of actively working.

https://doi.org/10.6061/clinics/2021/e2553 494 downloads

Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study
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Gonçalves, Fabio Augusto Rodrigues

; Besen, Bruno Adler Maccagnan Pinheiro

; Lima, Clarice Antunes de

; Corá, Aline Pivetta

; Pereira, Antônio José Rodrigues

; Perazzio, Sandro Félix

; Gouvea, Christiane Pereira

; Fonseca, Luiz Augusto Marcondes

; Trindade, Evelinda Marramon

; Sumita, Nairo Massakazu

; Duarte, Alberto José da Silva

; Lichtenstein, Arnaldo

; Bonfa, Eloisa

; Utiyama, Edivaldo M.

; Segurado, Aluisio C.

; Perondi, Beatriz

; Miethke-Morais, Anna

; Montal, Amanda C.

; Harima, Leila

; Fusco, Solange R. G.

; Silva, Marjorie F.

; Rocha, Marcelo C.

; Marcilio, Izabel

; Rios, Izabel Cristina

; Kawano, Fabiane Yumi Ogihara

; Jesus, Maria Amélia de

; Kallas, Ésper George

; Carmo, Carolina

; Tanaka, Clarice

; Souza, Heraldo Possolo de

; Marchini, Julio F. M.

; Carvalho, Carlos

; Ferreira, Juliana C.

; Levin, Anna Sara Shafferman

; Oliveira, Maura Salaroli

; Guimarães, Thaís

; Lázari, Carolina dos Santos

; Sabino, Ester

; Magri, Marcello M. C.

; Barros-Filho, Tarcisio E. P.

; Francisco, Maria Cristina Peres Braido

; Costa, Silvia F.

Clinics

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2021, Volume 76 elocation e3547

Resumo: En | Texto: En | PDF: En

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and these complications can lead to a poorer prognosis. This study aimed to evaluate the association and temporal trends of D-dimer and C-reactive protein (CRP) levels with the incidence of venous thromboembolism (VTE), hospital mortality, and costs among inpatients with COVID-19. METHODS: Data were extracted from electronic patient records and laboratory databases. Crude and adjusted associations for age, sex, number of comorbidities, Sequential Organ Failure Assessment score at admission, and D-dimer or CRP logistic regression models were used to evaluate associations. RESULTS: Between March and June 2020, COVID-19 was documented in 3,254 inpatients. The D-dimer level ≥4,000 ng/mL fibrinogen equivalent unit (FEU) mortality odds ratio (OR) was 4.48 (adjusted OR: 1.97). The CRP level ≥220 mg/dL OR for death was 7.73 (adjusted OR: 3.93). The D-dimer level ≥4,000 ng/mL FEU VTE OR was 3.96 (adjusted OR: 3.26). The CRP level ≥220 mg/dL OR for VTE was 2.71 (adjusted OR: 1.92). All these analyses were statistically significant (p<0.001). Stratified hospital costs demonstrated a dose-response pattern. Adjusted D-dimer and CRP levels were associated with higher mortality and doubled hospital costs. In the first week, elevated D-dimer levels predicted VTE occurrence and systemic inflammatory harm, while CRP was a hospital mortality predictor. CONCLUSION: D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.

https://doi.org/10.6061/clinics/2021/e3547

10.

New flavone and other compounds from Tephrosia egregia: assessing the cytotoxic effect on human tumor cell lines
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Teixeira, Maria V.S.

; Lima, Jefferson Q.

; Pimenta, Antônia T.A.

; Silva, Francisca R.L. da

; Oliveira, Maria da Conceição F. de

; Pereira, Italo G.

; Costa-Junior, Dilailson C.

; Ribeiro, Paulo R.V.

; Santiago, Gilvandete M.P.

; Lima, Mary Anne S.

; Braz-Filho, Raimundo

; Bezerra, Mirna M.

; Montenegro, Raquel C.

; Rocha, Danilo D.

; Moraes, Maria Elisabete A. de

; Medeiros, Aline C. de

; Arriaga, Angela M.C.

Revista Brasileira de Farmacognosia

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Jun 2018, Volume 28 Nº 3 Páginas 333 - 338

Resumo: En | Texto: En | PDF: En

ABSTRACT The organic extracts from stems, roots and leaves of Tephrosia egregia Sandwith, Fabaceae, provided a new flavone, 5-hydroxy-8-(1",2"-epoxy-3"-hydroxy-3"-methylbutyl)-7-methoxyflavone (1), in addition to eleven known compounds: pongaflavone (2), praecansone B (3), 12a-hydroxyrotenone (4), praecansone A, 2',6'-dimethoxy-4',5'-(2",2"-dimethyl)-pyranochalcone, pongachalcone, maackiain, β-sistosterol and its glucoside, p-cumaric acid and cinnamic acid. The structures of all compounds were established on the basis of spectroscopic methods, mainly 1D and 2D NMR and HRESIMS, involving comparison with literature data. Cytotoxicity of compounds 1–4 was evaluated against AGP-01 (cancerous ascitic fluid), HCT-116 (colon adenocarcinoma), HL-60 (leukemia), PC-3 (prostate carcinoma), SF-295 (glioblastoma) and SKMEL 28 (melanoma) cell lines.

https://doi.org/10.1016/j.bjp.2018.03.008 525 downloads

11.

Liver proteome of mice with different genetic susceptibilities to the effects of fluoride
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KHAN, Zohaib Nisar

; LEITE, Aline de Lima

; CHARONE, Senda

; SABINO, Isabela Tomazini

; MARTINI, Tatiana

; PEREIRA, Heloísa Aparecida Barbosa da Silva

; OLIVEIRA, Rodrigo Cardoso

; BUZALAF, Marília Afonso Rabelo

Journal of Applied Oral Science

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Jun 2016, Volume 24 Nº 3 Páginas 250 - 257

Resumo: En | Texto: En | PDF: En

ABSTRACT A/J and 129P3/J mice strains have been widely studied over the last few years because they respond quite differently to fluoride (F) exposure. 129P3/J mice are remarkably resistant to the development of dental fluorosis, despite excreting less F in urine and having higher circulating F levels. These two strains also present different characteristics regardless of F exposure. Objective In this study, we investigated the differential pattern of protein expression in the liver of these mice to provide insights on why they have different responses to F. Material and Methods Weanling male A/J and 129P3/J mice (n=10 from each strain) were pared and housed in metabolic cages with ad libitum access to low-F food and deionized water for 42 days. Liver proteome profiles were examined using nLC-MS/MS. Protein function was classified by GO biological process (Cluego v2.0.7 + Clupedia v1.0.8) and protein-protein interaction network was constructed (PSICQUIC, Cytoscape). Results Most proteins with fold change were increased in A/J mice. The functional category with the highest percentage of altered genes was oxidation-reduction process (20%). Subnetwork analysis revealed that proteins with fold change interacted with Disks large homolog 4 and Calcium-activated potassium channel subunit alpha-1. A/J mice had an increase in proteins related to energy flux and oxidative stress. Conclusion This could be a possible explanation for the high susceptibility of these mice to the effects of F, since the exposure also induces oxidative stress.

https://doi.org/10.1590/1678-775720150364 1819 downloads

12.

Anti-inflammatory activity and acute toxicity studies of hydroalcoholic extract of Herissantia tiubae
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Lima, Ana L.A.

; Alves, Adriano F.

; Xavier, Aline L.

; Mozzini-Monteiro, Talissa

; Oliveira, Theresa R.R.

; Leite, Fagner C.

; Matias, Wemerson N.

; Branco, Marianna V.S.C.

; Souza, Maria F.V.

; Piuvezam, Marcia R.

Revista Brasileira de Farmacognosia

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Abr 2016, Volume 26 Nº 2 Páginas 225 - 232

Resumo: En | Texto: En | PDF: En

ABSTRACT Hydroalcoholic extract of aerial parts of Herissantia tiubae (K. Schum.) Brizicky, Malvaceae, was evaluated in experimental models of inflammation and toxicity. For toxicity assays, male and female Swiss mice were orally treated with hydroalcoholic extract of H. tiubae (2000 mg/kg) and analyzed by consumption of water and food, body weight, mortality and rates of major organ weights, as well as biochemical and hematological indexes. For anti-inflammatory effect, phlogistic agents such as carrageenan or acetic acid were used to evaluate paw edema, cell migration and cytokine production. It was also investigated the hydroalcoholic extract of H. tiubae in RAW 264.7 macrophage lineage by nitric oxide and cytokine productions. Swiss mice treated with hydroalcoholic extract of H. tiubae showed low toxicity and (50 or 100 mg/kg) was able to reduce significantly (p < 0.01, p < 0.001) polymorphonuclear cell migration, TNF-α and IL-1β production in the carrageenan-induced peritonitis. However the hydroalcoholic extract of H. tiubae (50, 100 or 200 mg/kg) did not reduce carrageenan-induced paw edema. Additionally, hydroalcoholic extract of H. tiubae did not present cytotoxicity at concentrations of 6.25, 12.5, 25 or 50 µg/ml but induced significantly decrease of NO, TNF-α and IL-6 production in macrophage lineage. This study suggests that hydroalcoholic extract of H. tiubae has anti-inflammatory activity by inhibiting cell migration mainly by decreasing the inflammatory cytokine levels at the inflamed site independently of the anti-edematogenic effect.

https://doi.org/10.1016/j.bjp.2015.11.001 1701 downloads

13.

Association between Functional Variables and Heart Failure after Myocardial Infarction in Rats
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Polegato, Bertha F.

; Minicucci, Marcos F.

; Azevedo, Paula S.

; Gonçalves, Andréa F.

; Lima, Aline F.

; Martinez, Paula F.

; Okoshi, Marina P.

; Okoshi, Katashi

; Paiva, Sergio A. R.

; Zornoff, Leonardo A. M.

Arquivos Brasileiros de Cardiologia

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Fev 2016, Volume 106 Nº 2 Páginas 105 - 112

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Fundamento: A predição de insuficiência cardíaca após o infarto agudo do miocárdio pode ter importantes implicações clínicas. Objetivo: Analisar as variáveis funcionais ecocardiográficas associadas com insuficiência cardíaca no modelo do infarto em ratos. Métodos: Os animais foram divididos em dois grupos: infarto e controle. Após, os animais infartados foram divididos em grupos com e sem insuficiência cardíaca. Os valores preditivos foram avaliados por regressão logística. Os valores de corte preditivos de insuficiência cardíaca foram determinados por meio de curvas ROC. Resultados: Após 6 meses da cirurgia, 88 animais com infarto e 43 animais controle foram incluídos no estudo. O infarto aumentou os diâmetros das cavidades esquerdas, a massa e a espessura da parede do ventrículo esquerdo. Adicionalmente, o infarto resultou em disfunção sistólica e diastólica, caracterizada por menores valores da fração de variação de área, velocidade de encurtamento da parede posterior, tempo de desaceleração da onda E, associada com maiores valores da relação E/A e tempo de relaxamento isovolumétrico ajustado pela frequência cardíaca. Dentre os animais infartados, 54 (61%) desenvolveram insuficiência cardíaca. Ratos com insuficiência cardíaca apresentaram maiores índices de massa e diâmetros das cavidades esquerdas, associadas com piora das variáveis funcionais. A fração de variação de área, relação E/A, tempo de desaceleração da onda E e tempo de relaxamento isovolumétrico ajustado pela frequência cardíaca foram variáveis funcionais preditoras de insuficiência cardíaca. Os valores de corte das variáveis funcionais associados com insuficiência cardíaca foram: fração de variação de área < 31,18%; E/A > 3,077; tempo de desaceleração da onda E < 42,11 e tempo de relaxamento isovolumétrico ajustado pela frequência cardíaca < 69,08. Conclusão: Em ratos acompanhados por 6 meses após o infarto, a fração de variação de área, relação E/A, tempo de desaceleração da onda E e tempo de relaxamento isovolumétrico ajustado pela frequência cardíaca são preditores do aparecimento de insuficiência cardíaca.

Background: Heart failure prediction after acute myocardial infarction may have important clinical implications. Objective: To analyze the functional echocardiographic variables associated with heart failure in an infarction model in rats. Methods: The animals were divided into two groups: control and infarction. Subsequently, the infarcted animals were divided into groups: with and without heart failure. The predictive values were assessed by logistic regression. The cutoff values predictive of heart failure were determined using ROC curves. Results: Six months after surgery, 88 infarcted animals and 43 control animals were included in the study. Myocardial infarction increased left cavity diameters and the mass and wall thickness of the left ventricle. Additionally, myocardial infarction resulted in systolic and diastolic dysfunction, characterized by lower area variation fraction values, posterior wall shortening velocity, E-wave deceleration time, associated with higher values of E / A ratio and isovolumic relaxation time adjusted by heart rate. Among the infarcted animals, 54 (61%) developed heart failure. Rats with heart failure have higher left cavity mass index and diameter, associated with worsening of functional variables. The area variation fraction, the E/A ratio, E-wave deceleration time and isovolumic relaxation time adjusted by heart rate were functional variables predictors of heart failure. The cutoff values of functional variables associated with heart failure were: area variation fraction < 31.18%; E / A > 3.077; E-wave deceleration time < 42.11 and isovolumic relaxation time adjusted by heart rate < 69.08. Conclusion: In rats followed for 6 months after myocardial infarction, the area variation fraction, E/A ratio, E-wave deceleration time and isovolumic relaxation time adjusted by heart rate are predictors of heart failure onset.

https://doi.org/10.5935/abc.20160015 1985 downloads

14.

Assessment of intensity effort of middle-aged adults practicing regular walking
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Silva, Anderson A.

; Lima, Daniela A.

; Vieira, Gabriella F.

; Fernandes, Aline A.

; Pereira, Danielle A. G.

Brazilian Journal of Physical Therapy

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Dez 2015, Volume 19 Nº 6 Páginas 491 - 497

Resumo: En | Texto: En | PDF: En

Background: Walking is one of the most commonly recommended activities for sedentary individuals. When performed at the correct intensity, it can provide cardiovascular, respiratory, metabolic, and other benefits by providing a training effect in addition to reducing the risk of death from cardiovascular diseases and other chronic health conditions. Objectives: The primary aim of this study was to assess whether individuals who practiced regular unsupervised walking carry out the activity safely and with sufficient effort intensity parameters to have a positive physiological (training) effect. The secondary objective was to compare the training heart rate (HR) and the stability of the HR within the ideal range of training between the sexes. Method: Individuals were selected from walking tracks within the city of Belo Horizonte, Brazil. The study included subjects from 40 to 60 years of age who had practiced walking for at least two months prior to the study, walking at least three times a week. Individuals who agreed to participate in the survey were asked to walk 15 minutes at their usual pace with their HR measured every 5 minutes using a heart rate monitor. Their average walking HR was compared to the average training HR based on the formula: (220 - age) × 70 to 80% that would result in a positive physiological training effect. Results: Of the 142 individuals evaluated, 25.4% achieved the average training HR. This result was significantly lower than those who did not achieve the average training HR while walking (p=0.002). There were significant differences between men and women who had reached the training HR (p=0.0001). Conclusion: The authors found that individuals who walk regularly performed outside the range of the ideal HR intensity that would cause a positive physiological effect and therefore would probably not achieve a beneficial training effect while walking.

https://doi.org/10.1590/bjpt-rbf.2014.0125 1912 downloads

15.

Metalloproteomic Profile Determination of Muscle Samples from Nile Tilapia (Oreochromis niloticus) Using AAS and ESI-MS/MS after 2D-PAGE Separation
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Cavecci, Bruna

; Lima, Paula M. de

; Queiroz, João V. de

; Braga, Camila P.

; Padilha, Cilene C. F.

; Leite, Aline L.

; Buzalaf, Marília A. R.

; Pezzato, Luiz E.

; Padilha, Pedro M.

Journal of the Brazilian Chemical Society

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Fev 2015, Volume 26 Nº 2 Páginas 239 - 246

Resumo: En | Texto: En | PDF: En

This study evaluated the metalloproteomic profile of muscle tissue samples from Nile tilapia (Oreochromis niloticus). Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) methods was used for protein fractionation and identification based on image analysis. Determination of Ca, Cu, Fe, Mn and Zn was performed in the protein spots by flame and/or graphite furnace atomic absorption spectrometry (FAAS, GFAAS), the protein spots were characterized by electrospray ionization-tandem mass spectrometry (ESI-MS/MS). FAAS and GFAAS determinations have indicated the presence of calcium in seven protein spots, iron in only one spot, manganese in six spots, and zinc in two spots. Of the seventeen protein spots where the presence of metal ions was detected, ten were characterized by ESI-MS/MS.

https://doi.org/10.5935/0103-5053.20140260 1453 downloads

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