Pesquisa | SciELO

ABSTRACT Objective: To compare the agreement of images in white light (WL), fluorescence (FL), and digital radiographs (DR), on the diagnosis and treatment decisions for occlusal caries lesions against a micro-CT gold standard. Material and Methods: Ten extracted third molars, with enamel and/or dentin caries (ICDAS 2-4), were included. Occlusal surface images were acquired with an intraoral camera (SoproLife®) in WL and FL modes. DR was obtained using an intraoral X-ray and a semi-direct digital system. A total of 780 images were needed, organized in a template, to be later examined by twenty-six dentists invited to compose the study. The Generalized Estimation Equations model was used to compare the proportions of the correct answers between the three methods and the gold standard. When significant, Bonferroni post-hoc test was used to identify differences (α=5%). Results: Most of the examiners were specialists (76.9%) with 14.5 years of experience. All diagnostic methods were similar and showed low agreement (DR 12.7%, WL 16.5%, and FL 16.5%) compared with gold standard caries diagnostic scores. Regarding treatment decisions, mean agreement for all diagnostic methods was higher (43.2%; p<0.001), and among all methods, WL (48.1%) and FL (51.2%) modes performed better than DR (30.4%, p<0.001). Conclusion: SoproLife® images could help clinicians to propose rational, minimally invasive treatments for occlusal caries lesions.

https://doi.org/10.1590/pboci.2023.009

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2023, Volume 37 elocation e126

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

Perioperative management in gynecological surgery based on the ERAS program
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Santiago, Aline Evangelista

; Silva Filho, Agnaldo Lopes da

; Cândido, Eduardo Batista

; Ribeiro, Paulo Ayrosa

; Silva, Julio César Rosa e

; Primo, Walquíria Quida Salles Pereira

; Carvalho, Jesus Paula

; Podgaec, Sérgio

; Lino, Carlos Augusto Pires Costa

; Quintáiros, Ricardo de Almeida

; Brito, Luiz Gustavo Oliveira

Revista Brasileira de Ginecologia e Obstetrícia

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Fev 2022, Volume 44 Nº 2 Páginas 202 - 209

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1055/s-0042-1743401

World experiences in preceptorship in medical undergraduate education: an integrative review
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Nordi, Aline Barreto de Almeida

; Kishi, Renata Giannecchini Bongiovanni

; Carvalho, Beatriz Barea

; Evangelista, Danilo Nogueira

; Gaion, João Pedro de Barros Fernandes

; Saggin, Julia

; Maida, Letícia Bassani

; Silva, Majorie Valéria Lopes da

Revista Brasileira de Educação Médica

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2022, Volume 46 Nº 1 elocation e013

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: Introdução: O preceptor, como médico que facilita o processo ensino-aprendizagem nos cenários de prática, é essencial para o ensino em serviço na graduação em Medicina. A importância desses profissionais na formação de novos médicos expõe a necessidade de compreender a atividade de preceptoria na perspectiva da educação médica. Objetivo: Este estudo teve como objetivo verificar, na literatura científica, as experiências mundiais em preceptoria na graduação em Medicina. Método: Trata-se de revisão integrativa da literatura a partir de descritores padronizados nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Medical Literature Analysis and Retrieval System Online (MEDLINE) e Scientific Electronic Library Online (SciELO), entre 2009 e 2019. A análise dos artigos foi realizada por meio da técnica de categoria temática. Resultado: A busca nas bases de dados resultou em 274 estudos, dos quais 23 foram analisados e discutidos na íntegra. O detalhamento das experiências mundiais em preceptoria foi sistematizado em duas categorias: aspectos intrínsecos e extrínsecos para o exercício da preceptoria e estratégias educacionais utilizadas pelo preceptor. Conclusão: A análise dos artigos indica a importância da atuação dos estudantes em conjunto com os preceptores para aquisição de competências profissionais. Um fator crítico para o sucesso do acompanhamento de estudantes na prática profissional é a capacidade do preceptor em assumir o papel de educador, de modo a enxergar o estudante na sua singularidade e no desenvolvimento integral. Dessa forma, fica mais evidente a relevância da qualificação dos preceptores.

Abstract: Introduction: The preceptor, as the physician who facilitates the teaching-learning process in practice settings, is essential for in service-training in the undergraduate medical school. The importance of these professionals in the training of new physicians highlights the need to understand the preceptorship activity from a medical education perspective. Objective: To verify, in the scientific literature, global experiences in preceptorship in the undergraduate medical school. Method: Integrative literature review using standardized descriptors in the following databases: LILACS - Latin American and Caribbean Literature in Health Sciences, MEDLINE - Online System for Analysis and Recovery of Medical Literature and SciELO - Scientific Electronic Library Online, between 2009 to 2019. Analysis of the articles was carried out using the thematic category technique. Results: The search in the databases resulted in 274 studies, of which 23 were analyzed and discussed in full. Detailing of the global experiences in preceptorship was systematized into two categories: intrinsic and extrinsic aspects for the exercise of preceptorship and educational strategies used by the preceptor. Conclusions: The analysis of the articles indicates the importance of the students’ actions together with preceptors for the acquisition of professional skills. A critical factor for the success of monitoring students in professional practice is the preceptor’s ability to assume the role of educator, in order to see the students in their uniqueness and in their integral development. Therefore, the significance of the preceptors’ qualifications becomes more evident.

https://doi.org/10.1590/1981-5271v46.1-20210228.ing

Efeito de guia para raciocínio clínico na acurácia diagnóstica de estudantes de enfermagem: ensaio clínico
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Maurício, Aline Batista

; Cruz, Elaine Drehmer de Almeida

; Barros, Alba Lucia Bottura Leite de

; Tesoro, Mary Gay

; Lopes, Camila Takao

; Simmons, Anne Marie

; Lopes, Juliana de Lima

; Guandalini, Lidia Santiago

Revista Latino-Americana de Enfermagem

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2022, Volume 30 elocation e3515

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo avaliar o efeito do Guia Autoinstrucional para Raciocínio Clínico na acurácia diagnóstica de estudantes de Bacharelado em Enfermagem. Método ensaio clínico randomizado, paralelo, duplo cego (pesquisadores e avaliadores dos desfechos), realizado com graduandos de Enfermagem. Aplicaram-se, em duas fases, estudos de caso validados para a identificação de diagnóstico de enfermagem/problema do paciente, etiologia e pistas, sendo utilizado o Guia com o grupo intervenção na segunda fase. Os desfechos - acurácia diagnóstica, etiológica e número de pistas - foram avaliados por meio de rubricas validadas. Para análise, utilizou-se estatística descritiva para dados demográficos; teste exato de Fisher para similaridades na educação prévia e confiança; teste de Mann-Whitney para idade; teste ANOVA não paramétrico na avaliação da hipótese de diferenças no desempenho. Resultados amostra final composta por 24 estudantes no grupo controle e 27 no intervenção; sem diferença quanto ao sexo, idade e educação. Houve diferença para acurácia diagnóstica (p=0,041) e etiológica (p=0,0351) no grupo intervenção, mostrando efeito negativo da utilização do Guia. Conclusão a autoinstrução implementada uma única vez não foi efetiva em impactar a acurácia diagnóstica de estudantes solucionando estudos de caso. A aplicação repetida do Guia como ferramenta didática pode ser efetiva para melhorar tal desfecho. REBEC: RBR-4bhr78.

Abstract Objective to evaluate the effect of the Self-Instructional Guide for Clinical Reasoning on the diagnostic accuracy of undergraduate Nursing students. Method a randomized, parallel and double-blind (researchers and outcome evaluators) clinical trial, carried out with undergraduate Nursing students. Validated case studies were applied in two phases to identify the patient’s Nursing diagnosis/problem, etiology and clues, using the Guide with the intervention group in the second phase. The outcomes - diagnostic and etiological accuracy and number of clues - were evaluated using validated rubrics. Descriptive statistics were used to analyze demographic data; Fisher’s exact test for similarities in prior education and confidence; Mann-Whitney’s test for age; and non-parametric ANOVA test in the evaluation of the hypothesis of differences in performance. Results final sample composed of 24 students in the control group and 27 in the intervention group; no difference as to gender, age and schooling. There was a difference in diagnostic (p=0.041) and etiological (p=0.0351) accuracy in the intervention group, showing a negative effect of using the Guide. Conclusion the one-time self-instruction was not effective in impacting the diagnostic accuracy of students solving case studies. Repeated application of the Guide as a teaching tool can be effective in improving such outcome. REBEC: RBR-4bhr78.

Resumen Objetivo evaluar el efecto de la Guía Autoinstruccional de Razonamiento Clínico en la precisión diagnóstica de estudiantes de Licenciatura en Enfermería. Método ensayo clínico aleatorizado, paralelo, doble ciego (investigadores y evaluadores de resultados), realizado con estudiantes de la carrera de enfermería. Se aplicaron estudios de casos validados en dos fases para identificar el diagnóstico de enfermería/problema del paciente, etiología y pistas, utilizando la Guía con el grupo experimental en la segunda fase. Los resultados (precisión diagnóstica, etiológica y número de pistas) se evaluaron utilizando rúbricas validadas. Para el análisis se utilizó estadística descriptiva para datos demográficos; prueba exacta de Fisher para similitudes en educación previa y confianza; prueba de Mann-Whitney para la edad; prueba ANOVA no paramétrica en la evaluación de la hipótesis de diferencias en el desempeño. Resultados muestra final compuesta por 24 estudiantes en el grupo control y 27 en el grupo experimental; no había diferencias en cuanto al sexo, la edad y educación. Hubo diferencia en la precisión diagnóstica (p=0,041) y etiológica (p=0,0351) en el grupo experimental, que mostraron un efecto negativo del uso de la Guía. Conclusión la autoinstrucción implementada por única vez no fue efectiva para generar un impacto en la precisión diagnóstica de los estudiantes que resolvieron los estudios de casos. La aplicación repetida de la Guía como herramienta de enseñanza puede ser eficaz para mejorar dicho resultado. REBEC: RBR-4bhr78.

https://doi.org/10.1590/1518-8345.5452.3515

Efficacy of 30% and 38% Silver Diamine Fluoride in Arresting Caries Lesions After Different Application Times: An in Vitro Study
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Rodrigues, Gabriella Fernandes

; Monteiro, Amanda Souza Nunes

; Vollú, Ana Lúcia

; Pires, Paula Maciel

; Silva, Aline Saddock de Sá

; Lopes, Ricardo Tadeu

; Oliveira, Branca Heloisa

; Neves, Aline de Almeida

; Barja-Fidalgo, Fernanda

; Fonseca-Gonçalves, Andréa

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2022, Volume 22 elocation e210112

Resumo: En | Texto: En | PDF: En

Abstract Objective: To evaluate the efficacy of silver diamine fluoride (SDF) in arresting dentin caries lesions when applied under different concentrations and times. Material and Methods: Forty-two bovine blocks were selected and fixed in 24-well plates. Each well received a mixed bacterial inoculum added to the culture medium with 5% sucrose. The plates were incubated in microaerophilia (7 days) for caries formation, confirmed by micro-CT (M1). SDF was applied over the carious lesions for different times and concentrations (n=6): SDF 30% - immediate removal, 1 minute and 3 minutes; SDF 38%, - immediate removal, 1 minute and 3 minutes. The group without treatment was the control. Then, the samples were again scanned by micro-CT (M2) and submitted to a second cariogenic challenge for 21 days. Then, a final scan was performed (M3). Results: Mean pH at the culture medium and lesion depth were compared using Kruskal-Wallis and Wilcoxon tests. 38% SDF showed the lowest metabolic activity of the biofilm. All 38% groups and 30% 1 and 3 minutes did not show an increase in mean lesion depth comparing M3 with M1. However, only 30% 3 minutes and 38% 1 and 3 minutes showed a significant reduction of lesion depth. Conclusion: The minimum application time of 30% SDF to arrest dentin caries lesion was 1 minute, while 38% SDF arrested with application and immediate removal.

https://doi.org/10.1590/pboci.2022.019

In vitro effect of experimental nanocomposites solutions on the prevention of dental caries around orthodontic brackets
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Leite, Karla Lorene de França

; Vieira, Thiago Isidro

; Alexandria, Adílis Kalina

; Silva, Raphael Ferreira da

; Silva, Aline Saddock de Sá

; Lopes, Ricardo Tadeu

; Fonseca-Gonçalves, Andréa

; Neves, Aline de Almeida

; Cabral, Lúcio Mendes

; Pithon, Matheus Melo

; Cavalcanti, Yuri Wanderley

; Maia, Lucianne Cople

Brazilian Dental Journal

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Ago 2021, Volume 32 Nº 4 Páginas 62 - 73

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Este estudo teve como objetivo avaliar o efeito in vitro de uma única aplicação de soluções experimentais de nanocompósitos na prevenção de cárie dentária em braquetes ortodônticos. Os espécimes foram expostos a nanocompósitos de sílica mesoporosa (MS) contendo fluoreto por associação com tetrafluoreto de titânio (TiF4) ou fluoreto de sódio (NaF). Os nanocompósitos também podem conter cálcio e os grupos foram descritos como MSCaTiF4, MSTiF4, MSCaNaF, MSNaF e controles (TiF4 e NaF). Os espécimes foram submetidos à formação de um biofilme multiespécie para gerar um desafio cariogênico. Após 24h, o pH e a concentração de flúor solúvel total do meio de cultura foram avaliados. A perda mineral foi avaliada pela porcentagem de perda mineral superficial (% SML), variação do volume mineral (ΔZ) do esmalte interno e microscopia de luz polarizada (PL). A rugosidade superficial linear (Ra) e volumétrica (Sa) e a microscopia eletrônica de varredura (MEV) foram utilizadas para avaliar a topografia do esmalte. As análises estatísticas foram realizadas considerando p <0,05. MSNaF apresentou o maior valor de pH do meio de cultura após o desafio cariogênico, semelhante ao MSTiF4. Todas as soluções de nanocompósitos liberaram menos flúor do que seus controles NaF e TiF4 (p <0,05). Todas as soluções de nanocompósitos apresentaram% SML menor em comparação com seus respectivos grupos de controle (p <0,05). Ra, Sa e ΔZ menores foram observados para os grupos experimentais em comparação ao TiF4 (p <0,05). Os resultados foram confirmados por análises PL e SEM. As soluções experimentais de nanocompósitos contribuíram para a menor desmineralização do esmalte ao redor dos braquetes ortodônticos.

Abstract This study aimed to evaluate the in vitro effect of a single application of experimental nanocomposite solutions on the prevention of dental caries around orthodontic brackets. The specimens were exposed to mesoporous silica (MS) nanocomposites containing fluoride by association with titanium tetrafluoride (TiF4) or sodium fluoride (NaF). Nanocomposites also could contain calcium and groups were described as MSCaTiF4, MSTiF4, MSCaNaF, MSNaF, and controls (TiF4, and NaF). Specimens were subjected to the formation of a multispecies biofilm to generate a cariogenic challenge. After 24h, both pH and total soluble fluoride concentration of the culture medium were assessed. Mineral loss was evaluated by percentage of surface mineral loss (%SML), mineral volume variation (ΔZ) of inner enamel and polarized light microscopy (PL). Linear (Ra) and volumetric (Sa) surface roughness and scanning electronic microscopy (SEM) were used to assess enamel topography. Statistical analyses were conducted considering p<0.05. MSNaF had the highest value of culture medium pH after cariogenic challenge, similarly to MSTiF4. All nanocomposite solutions released less fluoride than their controls NaF and TiF4 (p<0.05). All nanocomposite solutions presented lower %SML compared to their respective control groups (p<0.05). Lower Ra, Sa and ΔZ were observed for experimental groups compared to TiF4 (p<0.05). The results were confirmed by PL and SEM analysis. The experimental nanocomposite solutions contributed for lower enamel demineralization around orthodontic brackets.

https://doi.org/10.1590/0103-6440202104331 41 downloads

Micro-CT evaluation of root canal preparation with rotary instrumentation on prototyped primary incisors
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MORAES, Rafael dos Reis

; PEREZ, Renata

; SILVA, Aline Saddock Sá da

; MACHADO, Alessandra Silveira

; LOPES, Ricardo Tadeu

; PINTOR, Andréa Vaz Braga

; PRIMO, Laura Guimarães

; NEVES, Aline de Almeida

Brazilian Oral Research

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2021, Volume 35 elocation e132

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to evaluate the endodontic instrumentation outcomes with asymmetrical files compared to reciprocating and hand files (HFs) in 3D-printed prototypes of upper primary incisors using micro-computed tomography (micro-CT). For this purpose, 50 prototypes were randomly divided (n = 10) according to the instrumentation technique as follows: HFs, a reciprocating file (WaveOne® Gold [WOG]), and three asymmetrical movement files: XP-Endo® Shaper (XPS), XP-Endo® Finisher (XPF), and XP Clean (XPC). The specimens were scanned and, after registration of the baseline and instrumented volumes, changes in the root canal volume (RCV), debris accumulation, removed root material volume (RRMV), non-instrumented areas, and the presence of cracks/perforations were quantified. Data were analyzed by analysis of variance and Student’s t-test, while the effect size was calculated for statistically significant outcomes. All groups showed an increase in RCV after instrumentation (p < 0.05), but this was higher with HFs (p < 0.05). Accumulated debris was higher for WOG and XPS (p < 0.05), but WOG exhibited more in the medium and apical third areas. HFs showed the highest RRMV (p < 0.05), especially at the apical third. The non-instrumented areas were lower for HFs and XPC than for the other systems (p < 0.05). Cracks were present in a few WOG (n = 2) and HF specimens (n = 3) and in this group, one of the cracked specimens and two others showed perforations. The asymmetric systems resulted in conservative dentin removal and fewer cracks/perforations as compared to HFs and a reciprocation file in prototyped primary upper incisors. XPC showed the best compromise between RRMV and non-instrumented areas with a low accumulation of debris.

https://doi.org/10.1590/1807-3107bor-2021.vol35.0132 1 downloads

Implications of iodine deficiency by gestational trimester: a systematic review
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Candido, Aline Carare

; Azevedo, Francilene Maria

; Machamba, Almeida Abudo Leite

; Pinto, Carina Aparecida

; Lopes, Sílvia Oliveira

; Macedo, Mariana de Souza

; Ribeiro, Sarah Aparecida Vieira

; Priore, Silvia Eloiza

; Franceschini, Sylvia do Carmo Castro

Archives of Endocrinology and Metabolism

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Out 2020, Volume 64 Nº 5 Páginas 507 - 513

Resumo: En | Texto: En | PDF: En

ABSTRACT As pregnant women are susceptible to changes in iodine, which can cause miscarriage, goiter, thyroid nodules, hypothyroidism, in addition to fetal neurological impairment or development. The aim of this study was to verify the implications of the iodine alteration in each gestational trimester and its consequences of physiological justification. The review was based on PRISMA. Searching for articles that took place in March 2020 without delimiting data. As bases consulted were the Clinical Trials, Cochrane Library, Lilacs and Medline (PubMed). The descriptors were combined as follows: "pregnancy" AND "iodine deficiency". Articles that addressed iodine deficiency and its implications were included. The selection followed the steps of reading the titles, abstracts and full articles. To assess the methodological quality of the studies, the STROBE Instruction instrument was used. The research resulted in 1,266 studies and 11 were included. In assessing methodological quality, the lowest score was and the maximum 20. According to studies, the fourth most affected by iodine loss are the second and third, it is possible to increase the volume and pneumatic nodules, subclinical hypothyroidism, pre-eclampsia, among others. The damages caused by iodine deficiency in the first or second trimester are still reversible, therefore, they need to be diagnosed early, to guarantee an iodic homeostasis and prevent damage to the health of the mother-child binomial.

https://doi.org/10.20945/2359-3997000000289 943 downloads

10.

Use of PET/CT to aid clinical decision-making in cases of solitary pulmonary nodule: a probabilistic approach
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Mourato, Felipe Alves

; Brito, Ana Emília Teixeira

; Romão, Monique Sampaio Cruz

; Santos, Renata Guerra Galvão

; Almeida, Cristiana Altino de

; Almeida Filho, Paulo José de

; Leal, Aline Lopes Garcia

Radiologia Brasileira

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Fev 2020, Volume 53 Nº 1 Páginas 1 - 6

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Determinar a frequência em que a PET/CT com FDG-18F muda a classificação de probabilidade de malignidade do nódulo pulmonar solitário. Materiais e Métodos: Foi realizada análise retrospectiva de todas as PET/CTs com FDG-18F realizadas entre maio/2016 e maio/2017 num serviço de medicina nuclear, cuja indicação era a avaliação de nódulo pulmonar solitário. Foram analisados os prontuários e os exames de PET/CT para coleta das informações necessárias para o cálculo da probabilidade pré-teste de malignidade pelo modelo de Swensen e pelo modelo de Herder. Probabilidade menor que 5% foi considerada como baixa, maior que 65% foi definida como alta, e os casos restantes, como intermediária. Os casos classificados como intermediários pelo modelo de Swensen foram reclassificados de acordo com o modelo de Herder. Resultados: Trinta e três pacientes foram incluídos neste estudo, 17 (51,5%) deles eram do gênero masculino, e a média de idade foi 68,63 anos (± 12,20 anos). Em relação à classificação da probabilidade de malignidade pelo modelo de Swensen, 23 (69,7%) apresentaram probabilidade intermediária de malignidade. Destes, o modelo de Herder classificou 6 casos (26,1%) como probabilidade baixa e 8 casos (34,8%) como probabilidade alta de malignidade. Conclusão: A PET/CT com FDG-18F foi capaz de modificar a classificação probabilística do nódulo pulmonar solitário em mais da metade dos casos.

Abstract Objective: To determine the frequency with which 18F-FDG-PET/CT findings change the probability of malignancy classification of solitary pulmonary nodules. Materials and Methods: This was a retrospective analysis of all 18F-FDG-PET/CT examinations performed for the investigation of a solitary pulmonary nodule between May 2016 and May 2017. We reviewed medical records and PET/CT images to collect the data necessary to calculate the pre-test probability of malignancy using the Swensen model and the Herder model. The probability of malignancy was classified as low if < 5%, intermediate if 5-65%, and high if > 65%. Cases classified as intermediate in the Swensen model were reclassified by the Herder model. Results: We reviewed the records for 33 patients, of whom 17 (51.5%) were male. The mean age was 68.63 ± 12.20 years. According to the Swensen model, the probability of malignancy was intermediate in 23 cases (69.7%). Among those, the application of the Herder model resulted in the probability of malignancy being reclassified as low in 6 (26.1%) and as high in 8 (34.8%). Conclusion: 18F-FDG-PET/CT was able to modify the probability of malignancy classification of a solitary pulmonary nodule in more than 50% of the cases evaluated.

https://doi.org/10.1590/0100-3984.2019.0034 1105 downloads

11.

BRAZILIAN SOCIETY OF HEPATOLOGY UPDATED RECOMMENDATIONS FOR DIAGNOSIS AND TREATMENT OF HEPATOCELLULAR CARCINOMA
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CHAGAS, Aline Lopes

; MATTOS, Angelo Alves de

; CARRILHO, Flair José

; BITTENCOURT, Paulo Lisboa

; VEZOZZO, Denise Cerqueira Paranaguá

; HORVAT, Natally

; ROCHA, Manoel de Souza

; ALVES, Venâncio Avancini Ferreira

; CORAL, Gabriela Perdomo

; ALVARES-DA-SILVA, Mario Reis

; BARROS, Fabio Marinho do Rego

; MENEZES, Marcos Roberto

; MONSIGNORE, Lucas Moretti

; COELHO, Fabricio Ferreira

; SILVA, Renato Ferreira da

; SILVA, Rita de Cássia Martins Alves

; BOIN, Ilka de Fatima Santana Ferreira

; D`ALBUQUERQUE, Luiz Augusto Carneiro

; GARCIA, José Huygens Parente

; FELGA, Guilherme Eduardo Gonçalves

; MOREIRA, Airton Mota

; BRAGHIROLI, Maria Ignez Freitas Melro

; HOFF, Paulo Marcelo Gehm

; MELLO, Vivianne Barretto de

; DOTTORI, Mariana Fonseca

; BRANCO, Tiago Pugliese

; SCHIAVON, Leonardo de Lucca

; COSTA, Thaisa de Fátima Almeida

Arquivos de Gastroenterologia

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2020, Volume 57 Supl. 1 Páginas 1 - 20

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O carcinoma hepatocelular (CHC) é uma das principais causas de mortalidade relacionada a câncer no Brasil e no mundo. A Sociedade Brasileira de Hepatologia (SBH) publicou em 2015 suas primeiras recomendações sobre a abordagem do CHC. Desde então, novas evidências sobre o diagnóstico e tratamento do CHC foram relatadas na literatura médica, levando a diretoria da SBH a promover uma reunião monotemática sobre câncer primário de fígado em agosto de 2018 com o intuito de atualizar as recomendações sobre o manejo da neoplasia. Um grupo de experts foi convidado para realizar uma revisão sistemática da literatura e apresentar uma atualização baseada em evidências científicas visando que pudesse nortear a prática clínica multidisciplinar do CHC. O texto resultante foi submetido a avaliação e aprovação de todos membros da SBH através de sua homepage. O documento atual é a versão final que contêm as recomendações atualizadas e revisadas da SBH.

ABSTRACT Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The Brazilian Society of Hepatology (SBH) published in 2015 its first recommendations about the management of HCC. Since then, new data have emerged in the literature, prompting the governing board of SBH to sponsor a single-topic meeting in August 2018 in São Paulo. All the invited experts were asked to make a systematic review of the literature reviewing the management of HCC in subjects with cirrhosis. After the meeting, all panelists gathered together for the discussion of the topics and the elaboration of updated recommendations. The text was subsequently submitted for suggestions and approval of all members of the Brazilian Society of Hepatology through its homepage. The present manuscript is the final version of the reviewed manuscript containing the recommendations of SBH.

https://doi.org/10.1590/s0004-2803.202000000-20 4088 downloads

12.

Sealing Carious Fissures with Resin Infiltrant in Association with a Flowable Composite Reduces Immediate Microleakage?
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Silva, Vanessa Brígido da

; Carvalho, Raquel Nogueira de

; Bergstrom, Tamiris Gomes

; Santos, Thais Maria Pires dos

; Lopes, Ricardo Tadeu

; Neves, Aline de Almeida

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2020, Volume 20 elocation e5114

Resumo: En | Texto: En | PDF: En

Abstract Objective: To compare the immediate microleakage of carious fissures sealed with a caries infiltrant covered by a flowable composite or solely with a flowable composite. Material and Methods: Extracted carious molars (n=20) were selected and paired among the experimental groups according to caries progression scores. Experimental groups (n=10) were divided according to the following sealing techniques: 1) caries infiltrant (Icon) + flowable composite (Z350 flow); 2) flowable composite (Z350 flow). Specimens were immersed in 3% methylene blue and evaluated in a stereomicroscope. Microleakage scores were attributed independently by two calibrated evaluators and the mode value was considered as the mean for the specimen. Binomial tests were used to test differences between two independent sample proportions at 5% significance level. Results: In the flowable composite group, a higher prevalence of dye penetration along the full depth of the fissure was observed, compared with caries infiltrant + flowable composite (p<0.05). For specimens showing dye penetration up to half of the fissure, in caries infiltrant + flowable composite group, all specimens showed dye penetration into the sealant, but not over the infiltrant. Conclusion: Using caries infiltrant as sealing material under a flowable composite cover is effective to improve the immediate sealing ability in carious fissures compared to sealing with flowable composite.

https://doi.org/10.1590/pboci.2020.067 780 downloads

13.

A COVID-19 na América Latina e suas repercussões para a odontologia
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Carrer, Fernanda Campos de Almeida

; Galante, Mariana Lopes

; Gabriel, Mariana

; Pischel, Nicole

; Giraldes, Amanda Iida

; Neumann, Aline

; Silva, Dorival Pedroso da

; Pucca Junior, Gilberto Alfredo

Revista Panamericana de Salud Pública

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2020, Volume 44 elocation e66

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.26633/rpsp.2020.66

14.

Transporting live silver catfish (Rhamdia quelen) with salt addition does not mitigate fish stress and negatively affects meat quality
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ROSA, Sheron Scholze

; BALDAN, Ana Paula

; BENDHACK, Fabiano

; PASCHOAL, Aline Fernanda Lopes

; CORDEIRO, Ananda Leticia Almeida

; KIRSCHNIK, Peter Gaberz

; BORGES, Tâmara Duarte

; MACEDO, Renata Ernlund Freitas

Food Science and Technology

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Dez 2019, Volume 39 Páginas 482 - 490

Resumo: En | Texto: En | PDF: En

Abstract This study evaluated the effects of NaCl added to water during silver catfish (Rhamdia quelen) transportation on stress and meat quality. Physiological indicators of stress (cortisol, glucose, circulating ions and liver glycogen) and meat quality parameters (rigor mortis, pH, instrumental color, psychotropic aerobic count and sensory analysis) were assessed. Adult silver catfish (n=380) were distributed in four experimental groups: T1: non-transported; T2: transported without NaCl water addition; T3: transported with 8.0-g NaCl L–1 water addition; T4: transported with 12.0-g NaCl L–1 water addition. The addition of NaCl was not effective at reducing blood cortisol in silver catfish (P>0.05). An osmotic imbalance was detected as an increase in sodium and calcium levels in the NaCl treatment groups. The 12.0-g NaCl L–1 treatment showed rigor mortis evolution in lesser time than the other treatments, and also presented redder meat color. The NaCl addition in transport water do not mitigate the stress in silver catfish, and in high concentrations (12.0-g L–1) was unfavorable for the homeostasis of fish and have negatively affected its meat quality.

https://doi.org/10.1590/fst.23318 532 downloads

15.

Is There Safety in the Use of Clopidogrel Loading Dose in Patients Over 75 Years of Age with Acute Coronary Syndrome?
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Soeiro, Alexandre de Matos

; Casale, Guilherme

; Lopes, Maria Antonieta Albanez Albuquerque de Medeiros

; Godoy, Lucas Colombo

; Bossa, Aline Siqueira

; Biselli, Bruno

; Leal, Tatiana de Carvalho Andreucci Torres

; Soeiro, Maria Carolina Feres de Almeida

; Serrano Jr., Carlos V

; Oliveira Jr., Múcio Tavares

International Journal of Cardiovascular Sciences

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Out 2019, Volume 32 Nº 5 Páginas 449 - 456

Resumo: En | Texto: En | PDF: En

Abstract Background: There is limited evidence in the literature regarding the administration of clopidogrel to acute coronary syndrome (ACS) in patients over 75 years of age. Most studies excluded this age group, making the subject controversial due to the increased risk of bleeding in this population. Objective: This is a retrospective, unicentric, and observational study aimed at assessing whether the administration of clopidogrel loading dose increases bleeding rates in patients over 75 years of age. Methods: Patients were divided into two groups: group I: 75 mg of clopidogrel; group II: 300-to 600-mg loading dose of clopidogrel. A total of 174 patients (129 in group I and 45 in group II) were included between May 2010 and May 2015. Statistical analysis: The primary outcome was bleeding (major and/or minor). The secondary outcome was combined events (cardiogenic shock, reinfarction, death, stroke and bleeding). The comparison between groups was performed through Q-square and T-test. The multivariate analysis was performed by logistic regression, being considered significant p < 0.05. Results: Comparisons between groups I and II showed differences in the prevalence of diabetes (46.5% vs. 24.4%, p = 0.01), arterial hypertension (90.7% vs. 75, p = 0.01), dyslipidemia (62% vs. 42.2%, p = 0.021), ST segment elevation (11.6% vs. 26.6%, p = 0.016) and coronary intervention percutaneous (16.5% vs. 62.2%, p < 0.0001), respectively. In the multivariate analysis, significant differences were observed between groups I and II in relation to the occurrence of bleeding (8.5% vs. 20%, OR = 0.173, 95% CI: 0.049 - 0.614, p = 0.007). Conclusion: A loading dose of 300 mg or more of clopidogrel.

https://doi.org/10.5935/2359-4802.20190031 1890 downloads

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