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ABSTRACT Introduction: HIV/AIDS is considered one of the great cases of public health, but it is seen that patients who use antiretroviral therapy (ART) and practice strength training promote a promotion of their health. Objectives: Assess the impact of strength and resistance training on cytokines and body composition in people living with HIV/AIDS. Methods: Randomized clinical trial, the sample consisted of 12 patients, 7 from the Strength Group (GF) and 5 from Group 2, Muscular Resistance (MGR). We compared the levels of IL-2, IL-4, IL-6, IL-10 and TNF-α cytokines and body composition in the first and last sessions. The patients completed 36 strength and resistance training sessions over 12 weeks. Results: After 36 sessions of GRM resistance training, there was a significant increase from 4,734 pg/mL to 5,050 pg/mL of IL-10 (p=0.002). Regarding the GFR, no significant results were found. For body composition, there were significant differences in GFR due to the increase in lean mass of the arms from 6,441g to 7,014g (p=0.04), legs from 16,379g to 17,281g (p=0.02) and whole body of 45,640g to 47,343g (p=0.01). In G2 there was a significant decrease in the percentage of fat in the arms from 23,160% to 20,750% (p = 0.04). To assess quality of life, the WHOQOL-HIV-Bref questionnaire was used, where significant improvement was found in all domains, except for the level of independence domain. Conclusion: We conclude that muscular resistance training is effective in increasing IL-10 and decreasing the percentage of fat in the arms, whereas strength training increases lean mass in arms, legs, and the whole body. Level of Evidence I; Randomized Clinical Trial.

RESUMEN Introducción: El VIH/SIDA es considerado uno de los grandes casos de salud pública, sin embargo, está comprobado que pacientes que hacen uso de la terapia antirretroviral (TARV) y practican entrenamiento de fuerza provoca una promoción de su salud. Objetivos: Evaluar el impacto del entrenamiento de fuerza en la resistencia a las citoquinas y en la composición corporal de las personas que viven con VIH/SIDA. Métodos: Ensayo clínico aleatorizado, la muestra estuvo compuesta por 12 pacientes, siete del Grupo de Fuerza (TFG) y cinco del Grupo de Resistencia Muscular (GRM). Se compararon los niveles de las citocinas IL-2, IL-4, IL-6, IL-10 y TNF-α y la composición corporal en la primera y la última sesión. Los pacientes completaron 36 sesiones de entrenamiento de fuerza y resistencia durante 12 semanas. Resultados: Tras 36 sesiones de entrenamiento de resistencia GRM, se produjo un aumento significativo de 4.734 pg/mL a 5.050 pg/mL de IL-10 (p=0,002). En cuanto a la TFG, no se encontraron resultados significativos. En cuanto a la composición corporal, hubo diferencias significativas en la TFG debido al aumento de la masa magra en brazos de 6.441g a 7.014g (p=0,04), piernas de 16.379g a 17.281g (p=0,02) y cuerpo entero de 45.640g a 47.343g (p=0,01). En el GRM hubo una disminución significativa del porcentaje de grasa en los brazos de 23.160% a 20.750% (p = 0,04). Para la evaluación de la calidad de vida se utilizó el cuestionario WHOQOL-HIV-Bref, donde se encontró una mejoría significativa en todos los dominios, excepto en el dominio nivel de independencia. Conclusión: Concluimos que el entrenamiento de resistencia muscular es eficaz para aumentar la IL-10 y disminuir el porcentaje de grasa en los brazos, mientras que el entrenamiento de fuerza aumenta la masa magra total. Nivel de Evidencia I; Ensayo clínico aleatorizado.

RESUMO Introdução: O HIV/AIDS é considerado um dos grandes casos de saúde pública, porém verifica-se que pacientes que fazem uso de terapia antirretroviral (TARV) e praticam treinamento de força provocam uma promoção de sua saúde. Objetivos: Avaliar o impacto do treinamento de força sobre a resistência nas citocinas e a composição corporal de pessoas vivendo com HIV/AIDS. Métodos: Ensaio clínico randomizado, a amostra foi composta por 12 pacientes, sendo sete do Grupo Força (TFG) e cinco do Grupo Resistência Muscular (GRM). Comparou-se os níveis das citocinas IL-2, IL-4, IL-6, IL-10 e TNF-α e a composição corporal na primeira e na última sessão. Os pacientes completaram 36 sessões de treinamento de força e resistência ao longo de 12 semanas. Resultados: Após 36 sessões de treinamento resistido GRM, houve um aumento significativo de 4.734 pg/mL para 5.050 pg/mL de IL-10 (p=0,002). Em relação à TFG, não foram encontrados resultados significativos. Para composição corporal, houve diferenças significativas na TFG devido ao aumento da massa magra dos braços de 6.441g para 7.014g (p=0,04), pernas de 16.379g para 17.281g (p=0,02) e corpo inteiro de 45.640g para 47.343g (p=0,01). No GRM houve diminuição significativa do percentual de gordura nos braços de 23.160% para 20.750% (p = 0,04). Para avaliação da qualidade de vida foi utilizado o questionário WHOQOL-HIV-Bref, onde foi encontrada uma melhora significativa em todos os domínios, exceto no domínio nível de independência. Conclusão: Conclui-se que o treinamento de resistência muscular é eficaz em aumentar a IL-10 e diminuir o percentual de gordura nos braços, enquanto o treinamento de força aumenta a massa magra geral. Nível de Evidência I; Ensaio Clínico Randomizado.

https://doi.org/10.1590/1517-8692202430012022_0123i

The impact of clinical presentation, presence of SIRS and organ dysfunction on mortality in bitches with pyometra
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Peixoto, Anna Julia Rodrigues

; Lima, Virgínia Conceição Tavares

; Fernandes, Maria Eduarda dos Santos Lopes

; Oliveira, Lucinéia Costa

; Blanc, Beatriz Teixeira

; Barros, Felipe Farias Pereira da Câmara

; Knackfuss, Fabiana Batalha

; Baldani, Cristiane Divan

; Coelho, Cássia Maria Molinaro

Ciência Rural

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2024, Volume 54 Nº 1 elocation e20220219

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT: This retrospective study evaluated the impact of the clinical presentation of pyometra on the morbidity and mortality of the affected bitches. The medical records of 47 bitches surgically treated for pyometra between May and December 2017 were evaluated. The admission data were analyzed to classify the animals according to the clinical presentation of pyometra, presence of systemic inflammatory response syndrome (SIRS) and organic dysfunctions (cardiovascular, neurological, renal, and hemostatic). The outcomes were recorded for up to 14 days. The overall mortality rate was 13%. Open and closed pyometra were identified in 62% (n= 29) and 38% (n= 18) of the cases, respectively. The SIRS was present in 44 (94%) bitches, and 27 (57%) had at least one organ dysfunction. The most prevalent dysfunction was hemostatic, followed by neurological, cardiovascular, and renal dysfunction. The clinical presentation of pyometra and the presence of SIRS did not correlate with each other, or with the presence of organ dysfunction and mortality. However, cumulative organ dysfunction (r=0.532, P=<0.001) and the presence of neurological (r= -0.371; P=0.012) and renal dysfunction (r=0.303; P=0.041) were correlated with mortality. Thus, the identification of organ dysfunction through physical examination and routine laboratory analysis proved to be more effective in identifying and predicting the critically ill patients than the SIRS criteria or clinical presentation of the disease.

RESUMO: O objetivo deste estudo retrospectivo foi avaliar o impacto da apresentação clínica da piometra na morbimortalidade das cadelas afetadas. Foram avaliados os registros clínicos de 47 cadelas tratadas cirurgicamente para piometra entre maio e dezembro de 2017. Os dados recolhidos na admissão foram analisados para classificar os animais quanto à apresentação clínica da piometra, presença de critérios da Síndrome da Resposta Inflamatória Sistêmica (SRIS) e disfunções orgânicas - cardiovascular, neurológica, renal e hemostática. Foi registrado o desfecho durante 14 dias. A mortalidade global foi de 13%. Piometra aberta e fechada foram identificadas em 62% (n= 29) e 38% (n= 18) respectivamente. SRIS esteve presente em 44 (94%) cadelas e 27 (57%) tiveram pelo menos uma disfunção orgânica. A disfunção mais prevalente foi a hemostática, seguida da neurológica, cardiovascular e renal. A apresentação clínica da piometra e a presença de SRIS não se correlacionaram entre si ou com presença de disfunção orgânica e mortalidade. No entanto, a quantidade de disfunções orgânicas (r=0.532, P=<0.001) e a presença das disfunções neurológica (r= -0.371; P=0.012) e renal (r=0.303; P=0.041) foram correlacionados com mortalidade. Assim, a identificação de disfunções orgânicas através do exame físico e análises laboratoriais de rotina mostrou-se mais eficaz na identificação e previsão de pacientes críticos do que os critérios de SRIS ou a apresentação clínica da doença.

https://doi.org/10.1590/0103-8478cr20220219

Mito e religião na tríplice fronteira Roraima, Guiana e Venezuela: o Areruya e o entre-lugar
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Albano, Adriana Helena de Oliveira

; Silva Neto, João Paulino da

Bakhtiniana: Revista de Estudos do Discurso

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2024, Volume 19 Nº 1 elocation e61875p

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT This article, about the Areruya religion of the Ingarikó people in the village of Manalai, located in the state of Roraima, Brazil, compares the discourse of two myths about the origin of the current Areruya. One of the myths was transcribed by Audrey Butt Colson (1960) in the 1950s, and the other by the anthropologist Maria Virgínia do Amaral (2019) between 2014 and 2017. The objective of comparing the two discourses was to present the articulations of each one for a new cosmological and social configuration, following the arrival of the colonizer. To achieve this, we used the idea of the “in-between” from the studies of Homi Bhabha (1994) in The Location of Culture because it allows for the use of text analysis as discourse without fixing any intrinsic meaning to them, creating a sliding space.

RESUMO Este artigo sobre a religião Areruya dos Ingarikó da aldeia Manalai, localizada no estado de Roraima, compara o discurso de dois mitos sobre a origem do atual Areruya. Um dos mitos foi transcrito por Audrey Butt Colson (1960) na década de 1950 e o outro pela antropóloga Maria Virgínia do Amaral (2019) entre 2014 e 2017. O objetivo da comparação entre os dois discursos foi apresentar as articulações de cada um para uma nova configuração cosmológica e social, a partir da chegada do colonizador. Para tanto, fizemos uso da ideia de entre-lugar oriunda dos estudos de Homi Bhabha (2001) - em O local da cultura -, porque ela permite utilizar o método de análise de textos como discurso sem fixar algum sentido intrínseco a eles, criando um espaço deslizante.

https://doi.org/10.1590/2176-4573p61875

“Mãe é só uma!”: violência institucional nas experiências de dupla maternidade na atenção à saúde
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Ril, Stephany Yolanda

; Oliveira Junior, João Batista de

; Mello, Mônica Machado Cunha e

; Portes, Virgínia de Menezes

; Moretti-Pires, Rodrigo Otávio

Ciência & Saúde Coletiva

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2024, Volume 29 Nº 4 elocation e19802023

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivou-se compreender as experiências de dupla maternidade na atenção à saúde durante o pré-natal, parto e puerpério a partir de um método qualitativo, utilizando entrevistas individuais on-line e grupo focal on-line assíncrono com mulheres cisgêneros, a maioria em relacionamentos homoafetivos. Os resultados revelaram a marginalização das vivências parentais dessas mulheres, destacando a violência institucional presente nos serviços de saúde brasileiros, sendo apresentados em dois eixos temáticos: 1) Cisheteronormatividade e seu impacto nas experiências de dupla maternidade e 2) Violência institucional nos serviços de saúde: da curiosidade à LGBTQIA+fobia. Conclui-se que a cisheteronormatividade prejudica a atenção à saúde para essas experiências, especialmente ao invisibilizar a mãe não gestante, destacando a urgência de capacitar profissionais de saúde, repensar e desafiar as normas cisgênero e heterossexuais e promover políticas inclusivas para garantir cuidados equitativos e combater a violência institucional.

Abstract The objective was to understand experiences of double motherhood during antenatal, childbirth and postpartum healthcare, using a qualitative method involving individual online interviews and asynchronous, online focus groups of cisgender women, mostly in same-sex relationships. The results revealed how these women’s experiences of parenting were marginalised, highlighting institutional violence in Brazilian healthcare services, which are presented here in two thematic dimensions: 1) Cisheteronormativity and its impact on experiences of double motherhood; and 2) Institutional violence in healthcare services: from curiosity to LGBTQIA+phobia. It was concluded that cisheteronormativity hinders healthcare for these experiences, especially by rendering the non-gestational mother invisible. This underscores the urgent need to train healthcare personnel, rethink and challenge cisgender and heterosexual norms and promote inclusive policies to ensure equitable care and combat institutional violence.

https://doi.org/10.1590/1413-81232024294.19802023

Organic residues influences the production and antioxidant activity of Campomanesia adamantium (Cambess.) O. Berg.
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Coelho, Dioelen Virginia Borges Souza de Aquino

; Vieira, Maria do Carmo

; Heredia-Zárate, Néstor Antônio

; Carnevali, Thiago de Oliveira

; Cardoso, Cláudia Andrea Lima

; Carnevali, Natália Hilgert de Souza

Revista Ceres

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Jun 2023, Volume 70 Nº 3 Páginas 64 - 71

Resumo: En | Texto: En | PDF: En

ABSTRACT Campomanesia adamantium (Cambess.) O. Berg (guavira) is a native plant of the Cerrado and Pantanal, which has several medicinal activities and fruits with a unique flavor rich in vitamin C. The species does not have defined cultivation methods, requiring studies to increase biomass production. An alternative is the use of organic residues that can influence the chemical, physical and biological characteristics of soils and consequently increase plant production. Thus, the objective was to evaluate the effect of different organic residues and bokashi, on the biomass production of plants and on the levels of phenols, flavonoids and antioxidant activity of tea from the leaves of guavira. Five substrates were studied in pots and protected environment: soil; soil + rice husk chicken manure; soil + sawdust chicken manure; soil + castor bean cake; soil + Organosuper® with or without the use of Bokashi in a 5x2 factorial scheme, in a randomized block experimental design. It was observed that the rice husk chicken manure can be used to increase the initial growth and biomass production of guavira keeping the leaves antioxidant activity tea stable. The use of bokashi benefits the growth of guavira only when no other organic residue is added to soil.

https://doi.org/10.1590/0034-737x202370030007

Morphofunctional regeneration by mesenchymal stem cell and IGF-1 inoculation in a model of facial nerve crush injury in rats
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Vieira, Aracele Gonçalves

; Guzen, Fausto Pierdona

; Paiva, José Rodolfo Lopes de

; Oliveira, Lucídio Clebeson de

; Jales, Maria Clara de Araújo

; Lucena, Eudes Euler de Souza

; Lucena, Virgínia Raquel dos Santos

; Morais, Hécio Henrique Araújo de

Brazilian Journal of Otorhinolaryngology

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Abr 2023, Volume 89 Nº 2 Páginas 244 - 253

Resumo: En | Texto: En | PDF: En

Abstract Objective: To analyze the morphofunctional regeneration process of facial nerve injury in the presence of insulin-like growth factor-1 and mesenchymal stem cells. Methods: Fourteen Wistar rats suffered unilateral facial nerve crushing and were randomly divided into two groups. All received insulin-like growth factor-1 inoculation, but only half of the animals received an additional inoculation of mesenchymal stem cells. The animals were followed for 90 days and facial nerve regeneration was analyzed via spontaneous facial motor function tests and immunohistochemistry in the nerve motor nucleus. Results: The group that received the growth factor and stem cells showed a statistically superior mean in vibrissae movements (p<0.01), touch reflex (p = 0.05) and eye closure (p<0.01), in addition to better immunohistochemistry reactivity. There was a statistically significant difference in the mean number of cells in the facial nerve nucleus between the experimental groups (p = 0.025), with the group that received the growth factor and stem cells showing the highest mean. Conclusion: The association between growth factor and stem cells potentiates the morphofunctional regeneration of the facial nerve, occurring faster and more effectively. Level of Evidence: 4, degree of recommendation C.

https://doi.org/10.1016/j.bjorl.2022.04.006

The pandemic changes daily life and ways of living: technosociality and user/families experiences
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Nascimento, Leila Cristine do

; Silva, Tamires Carolina da

; Tafner, Daniela Priscila Oliveira do Vale

; Oliveira, Virgínia Junqueira

; Viegas, Selma Maria da Fonseca

Revista Brasileira de Enfermagem

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2023, Volume 76 Supl. 1 elocation e20220177

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objectives: understand the changes imposed by the COVID-19 pandemic in the daily lives of users of Primary Health Care and their families and its impact on self-care and health promotion. Methods: this is a holistic-qualitative multiple case study, based on the Comprehensive Sociology of Everyday Life, in which 61 users participated. Results: experiencing a new daily life in COVID-19 pandemic times, users express their feelings, adaptation to new habits and ways of living. Health technologies and virtual social networks stand out in helping with everyday tasks, in communicating with loved ones and health professionals, and in validating dubious information. Faith and spirituality arise in the face of uncertainty and suffering. Final Considerations: it is imperative to pay close attention to the changes in daily life caused by the COVID-19 pandemic, in order to offer care directed to the singular and collective needs.

RESUMEN Objetivos: comprender los cambios impuestos por la pandemia de la COVID-19 en el cotidiano de los usuarios de la Atención Primaria de Salud y sus familias y su impacto en el autocuidado y la promoción de la salud. Métodos: se trata de un estudio de caso múltiple holístico-cualitativo, basado en la Sociología Integral de la Vida Cotidiana, en el que participaron 61 usuarios. Resultados: experimentando una nueva cotidianidad en tiempos de la pandemia del COVID-19, los usuarios expresan sus sentimientos, adaptación a nuevos hábitos y formas de vivir. Las tecnologías de la salud y las redes sociales virtuales se destacan para ayudar en las tareas cotidianas, en la comunicación con los seres queridos y profesionales de la salud, y en la validación de información dudosa. La fe y la espiritualidad surgen ante la incertidumbre y el sufrimiento. Consideraciones Finales: es imperativo prestar mucha atención a los cambios en la vida cotidiana provocados por la pandemia de la COVID-19, a fin de ofrecer una atención dirigida a las necesidades singulares y colectivas.

RESUMO Objetivos: compreender as mudanças impostas pela pandemia de COVID-19 no quotidiano de usuários da Atenção Primária à Saúde e suas famílias e seu impacto no autocuidado e na promoção da saúde. Métodos: trata-se de estudo de casos múltiplos holístico-qualitativo, fundamentado na Sociologia Compreensiva do Quotidiano, no qual participaram 61 usuários. Resultados: vivenciando um novo quotidiano em tempos da pandemia de COVID-19, os usuários expressam seus sentimentos, a adaptação aos novos hábitos e modos de viver. As tecnologias em saúde e as redes sociais virtuais se destacam no auxílio às tarefas cotidianas, para a comunicação com entes queridos e os profissionais da saúde, e na validação de informações duvidosas. A fé e a espiritualidade surgem diante de incertezas e sofrimento. Considerações Finais: é imperativo um olhar atento às transformações no quotidiano causadas pela pandemia de COVID-19, a fim de ofertar um cuidado direcionado às necessidades singulares e do coletivo.

https://doi.org/10.1590/0034-7167-2022-0177

Os bebês na sala do berçário: diferentes trajetórias no espaço
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Oliveira, Virgínia Souza

; Marques, Rafaela Ferreira

; Neves, Vanessa Ferraz Almeida

Educação e Pesquisa

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2023, Volume 49 elocation e255022

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract This paper analyzes how two babies, ages ten to twelve months, explored the space in an infants’ classroom during their entry process in an Early Childhood Education Center in Belo Horizonte, Brazil. While in the field, during the 2017 school year, the following research instruments were used: participant observation, video recordings and fieldnotes. Ethnography in education, in dialogue with cultural-historical psychology and Henri Lefebvre’s production of space theory, enabled us to perceive the baby in a space that is both product and production of such a person. The babies experienced and explored the classroom space during their entry process in the daycare center in different ways: (i) by watching, (ii) walking, (iii) crawling, (iv) touching, (v) fighting for toys, (vi) crying, (vii) learning how to care, (viii) sleeping, (ix) interacting with their peers and other people around them. The babies’ exploration trajectories in this classroom were constituted by the dialectic unity [perception/action], as babies [perceive/act] on the space, the objects, and the people seeking to familiarize themselves with this new space. There was, then, an active search, by the babies, for a recognition of the space and people, so that, perhaps, they could feel belonging to this social environment.

Resumo Este artigo teve por objetivo analisar como dois bebês, com idades entre dez e doze meses, exploraram o espaço de uma sala de berçário durante seu processo de inserção em uma Escola Municipal de Educação Infantil (EMEI) de Belo Horizonte. No tempo de permanência em campo, durante o ano letivo de 2017, utilizaram-se os seguintes instrumentos de pesquisa: observação participante, videogravações e anotações em diários de campo. A etnografia em educação, em diálogo com a psicologia histórico-cultural e com a teoria da produção do espaço de Henri Lefebvre, possibilitou perceber o/a bebê em um espaço que é produto e produção de tal pessoa. Os/as bebês vivenciaram e exploraram o espaço do berçário, durante seu processo de inserção na creche, de maneiras distintas: (i) por meio do olhar, (ii) do caminhar, (iii) do engatinhar, (iv) do toque, (v) das disputas por brinquedos, (vi) do choro, (vii) do aprendizado do cuidado, (viii) do sono, (ix) dos encontros desses bebês com seus pares e com outras pessoas ali presentes. As trajetórias de exploração dos/as bebês nesse berçário foram marcadas pela unidade dialética [percepção/ação], pois os/as bebês [percebem/agem] sobre o espaço, os artefatos e sobre as pessoas em busca de se familiarizarem com esse novo espaço em que foram inseridos. Houve, então, uma ativa busca, por parte dos/as bebês, de um conhecimento/reconhecimento do espaço e das pessoas para que, talvez, pudessem se sentir pertencentes a esse meio social.

https://doi.org/10.1590/s1678-4634202349255022por

Cadmium and copper transport in alluvial soils in the Brazilian semiarid region: column percolation and modeling
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Barros, Vitor Hugo de Oliveira

; Alves, Adriana Thays Araújo

; Santos Neto, Severino Martins dos

; Coutinho, Artur Paiva

; Lassabatere, Laurent

; Gondim, Manuella Virgínia Salgueiro

; Antonino, Antonio Celso Dantas

Revista Brasileira de Ciência do Solo

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2023, Volume 47 elocation e0220153

Resumo: En | Texto: En | PDF: En

ABSTRACT Regarding the Brazilian textile industry, part of the northeast region stands out as the second-largest textile manufacturing hub in the country. Despite its importance, this industrial activity has been bringing relevant environmental concerns regarding the disposal of textile effluents, especially from industrial laundries. This waste contains many chemicals and among them are various types of heavy metals. To assess environmental risks associated with heavy metals, pollutant transfer needs to be investigated. This study evaluated the retention and mobility of heavy metals Cd and Cu in alluvial soil, through soil column tests. The up-flow column percolation tests were performed using a nonreactive tracer (KBr) at a concentration of 0.3 mol L-1 and injecting a metallic solution containing Cu and Cd at 100 and 60 mg L-1, respectively. The injection flow rate was 0.75 mL min-1. The hydro-dispersive parameters were obtained by modeling the observed breakthrough curves with the convection-dispersion equation (CDE) and the two-region model, also referred to as the MIM (Mobile-IMmobile waters) model. The transport parameters were obtained from the two-site model (TSS). All elution curves were fitted to the models with the CXTFIT 2.0 program. The Two-Site Sorption Model was the best for the case studied, with R2 of 0.985 and 0.995 for Cu and Cd, respectively. The values of R were considerably higher than the unit, presenting an average of 2.138 for Cu and 1.907 for Cd. This indicates a delay of these contaminants when leaving the column, which is caused by the interaction of these chemical compounds with the soil. The values obtained for parameter D were 3.469 for Cu and 5.205 for Cd. Thus, the metals in this study present a risk of groundwater contamination for the local alluvial aquifers. The main reason for that is the physicochemical features of the soil, such as high sand content (85 %) and low OM content (2.1 %). The results also indicated greater retention and less mobility for Cu than for Cd, pointing to a greater risk for Cd.

https://doi.org/10.36783/18069657rbcs20220153

10.

A brazilian nationwide multicenter study on deficiency of deaminase-2 (DADA2)
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Melo, Adriana

; Carvalho, Luciana Martins de

; Ferriani, Virginia Paes Leme

; Cavalcanti, André

; Appenzeller, Simone

; Oliveira, Valéria Rossato

; Chong Neto, Herberto

; Rosário, Nelson Augusto

; Poswar, Fabiano de Oliveira

; Guimaraes, Matheus Xavier

; Kokron, Cristina Maria

; Maia, Rayana Elias

; Silva, Guilherme Diogo

; Keller, Gabriel

; Ferreira, Mauricio Domingues

; Vasconcelos, Dewton Moraes

; Toledo-Barros, Myrthes Anna Maragna

; Barros, Samar Freschi

; Rosa Neto, Nilton Salles

; Krieger, Marta Helena

; Kalil, Jorge

; Mendonça, Leonardo Oliveira

Advances in Rheumatology

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2023, Volume 63 elocation 23

Resumo: En | Texto: En | PDF: En

Abstract Introduction The deficiency of ADA2 (DADA2) is a rare autoinflammatory disease provoked by mutations in the ADA2 gene inherited in a recessive fashion. Up to this moment there is no consensus for the treatment of DADA2 and anti-TNF is the therapy of choice for chronic management whereas bone marrow transplantation is considered for refractory or severe phenotypes. Data from Brazil is scarce and this multicentric study reports 18 patients with DADA2 from Brazil. Patients and methods This is a multicentric study proposed by the Center for Rare and Immunological Disorders of the Hospital 9 de Julho - DASA, São Paulo - Brazil. Patients of any age with a confirmed diagnosis of DADA2 were eligible for this project and data on clinical, laboratory, genetics and treatment were collected. Results Eighteen patients from 10 different centers are reported here. All patients had disease onset at the pediatric age (median of 5 years) and most of them from the state of São Paulo. Vasculopathy with recurrent stroke was the most common phenotype but atypical phenotypes compatible with ALPS-like and Common Variable Immunodeficiency (CVID) was also found. All patients carried pathogenic mutations in the ADA2 gene. Acute management of vasculitis was not satisfactory with steroids in many patients and all those who used anti-TNF had favorable responses. Conclusion The low number of patients diagnosed with DADA2 in Brazil reinforces the need for disease awareness for this condition. Moreover, the absence of guidelines for diagnosis and management is also necessary (t).

https://doi.org/10.1186/s42358-023-00303-5

11.

The SISBIOTA-Diptera Brazilian Network: A long-term survey of Diptera from unexplored Brazilian Western Arc of Amazon, Cerrado, and Pantanal
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Lamas, Carlos José Einicker

; Fachin, Diego Aguilar

; Falaschi, Rafaela Lopes

; Alcantara, Daniel Máximo Correa de

; Ale-Rocha, Rosaly

; Amorim, Dalton de Souza

; Araújo, Maíra Xavier

; Ascendino, Sharlene

; Baldassio, Letícia

; Bellodi, Carolina Ferraz

; Bravo, Freddy

; Calhau, Julia

; Capellari, Renato Soares

; Carmo-Neto, Antonio Marcelino do

; Cegolin, Bianca Melo

; Couri, Márcia Souto

; Carvalho, Claudio José Barros de

; Dios, Rodrigo de Vilhena Perez

; Falcon, Aida Vanessa Gomez

; Fusari, Livia Maria

; Garcia, Carolina de Almeida

; Gil-Azevedo, Leonardo Henrique

; Gomes, Marina Morim

; Graciolli, Gustavo

; Gudin, Filipe Macedo

; Henriques, Augusto Loureiro

; Krolow, Tiago Kütter

; Mendes, Luanna Layla

; Limeira-de-Oliveira, Francisco

; Maia, Valéria Cid

; Marinoni, Luciane

; Mello, Ramon Luciano

; Mello-Patiu, Cátia Antunes de

; Morales, Mírian Nunes

; Oliveira, Sarah Siqueira

; Patiu, Claudemir

; Proença, Barbara

; Pujol-Luz, Cristiane Vieira de Assis

; Pujol-Luz, José Roberto

; Rafael, José Albertino

; Riccardi, Paula Raile

; Rodrigues, João Paulo Vinicios

; Roque, Fabio de Oliveira

; Sallum, Maria Anice Mureb

; Santis, Marcelo Domingos de

; Santos, Charles Morphy Dias dos

; Santos, Josenilson Rodrigues dos

; Savaris, Marcoandre

; Shimabukuro, Paloma Helena Fernandes

; Silva, Vera Cristina

; Schelesky-Prado, Daniel de Castro

; Silva-Neto, Alberto Moreira da

; Camargo, Alexssandro

; Sousa, Viviane Rodrigues de

; Urso-Guimarães, Maria Virginia

; Wiedenbrug, Sofia

; Yamaguchi, Carolina

; Nihei, Silvio Shigueo

Revista Brasileira de Entomologia

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2023, Volume 67 Nº 4 elocation e20230051

Resumo: En | Texto: En | PDF: En

ABSTRACT The SISBIOTA-BRASIL was a three-year multimillion-dollar research program of the Brazilian government to document plants and animals in endangered/understudied areas and biomes in Brazil. Distributional patterns and the historical events that generated them are extensively unknown regarding Brazilian fauna and flora. This deficiency hinders the development of conservation policies and the understanding of evolutionary processes. Conservation decisions depend on precise knowledge of the taxonomy and geographic distribution of species. Given such a premise, we proposed to research the diversity of Diptera of the Brazilian western arc of Amazon, Cerrado, and Pantanal in the states of Mato Grosso, Mato Grosso do Sul, and Rondônia. Three important biomes of the South American continent characterize these Brazilian states: Amazon forest, Cerrado (Brazilian Savannah), and Pantanal. Besides their ecological relevance, these biomes historically lack intensive entomological surveys. Therefore, they are much underrepresented in the Brazilian natural history collections and in the scientific literature, which is further aggravated by the fact that these areas are being exponentially and rapidly converted to commercial lands. Our project involved over 90 collaborators from 24 different Brazilian institutions and one from Colombia among researchers, postdocs, graduate and undergraduate students, and technicians. We processed and analyzed nearly 300,000 specimens from ~60 families of Diptera collected with a large variety of methods in the sampled areas. Here, we provide a detailed overview of the genera and species diversity of 41 families treated. Our results point to a total of 2,130 species and 514 genera compiled and identified for the three states altogether, with an increase of 41% and 29% in the numbers of species and genera known for the three states combined, respectively. Overall, the 10 most species-rich families were Tachinidae, Cecidomyiidae, Tabanidae, Psychodidae, Sarcophagidae, Stratiomyidae, Bombyliidae, Syrphidae, Tephritidae, and Asilidae. The 10 most diverse in the number of genera were Tachinidae, Stratiomyidae, Asilidae, Mycetophilidae, Syrphidae, Tabanidae, Muscidae, Dolichopodidae, Sarcophagidae, and Chloropidae. So far, 111 scientific papers were published regarding taxonomic, phylogenetic, and biogeographical aspects of the studied families, with the description of 101 new species and three new genera. We expect that additional publications will result from this investigation because several specimens are now curated and being researched by specialists.

https://doi.org/10.1590/1806-9665-rbent-2023-0051

12.

β-Cyclodextrins alter the energy metabolism-related enzyme activities in rats
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IANISKI, FRANCINE R.

; OLIVEIRA, AMANDA L. DE

; MEZZOMO, NATHANA JAMILLE

; FRANCESCHI, ITIANE D. DE

; CARMO, GUILHERME M. DO

; CREMONESE, CAMILA R.

; BALDISSERA, MATHEUS D.

; ZANON, JENIFER P.

; KOLLING, JENIFER

; FRIEDERICH, JORDANA DANIELA

; SILVA, IVANA Z.

; GIONGO, JANICE L.

; FEKSA, LUCIANE R.

; VAUCHER, RODRIGO A.

; WANNMACHER, CLOVIS MILTON D.

; RECH, VIRGINIA C.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Nº 2 elocation e20201783

Resumo: En | Texto: En | PDF: En

Abstract Although widely used in medicine, separation technology, and other fields, the effects of cyclodextrins on the activities of phosphoryl transfer enzymes have not been previously evaluated. In vivo studies evaluated the function of cyclodextrins as active compounds. Despite the use of cyclodextrins as active compounds, the effects of cyclodextrins on hepatic and renal tissues remain to be fully elucidated. The primary objective of this study was to evaluate the effects of β- cyclodextrins, methyl-β-cyclodextrin (M-β- cyclodextrins), and (2-hydroxypropyl)-β-cyclodextrin (HP-β-cyclodextrins) on enzyme activities regulating the maintenance of energy homeostasis in the kidney and liver tissues in relation to toxicity. Serum levels of liver and kidney markers were measured, and oxidative stress parameters were assessed. After 60-day treatments, we observed that the administration of β-cyclodextrins and M-β-cyclodextrins inhibited the hepatic activity of pyruvate kinase, an irreversible enzyme within the glycolytic pathway. Additionally, administration of HP-β-cyclodextrins inhibited creatine kinase activity and increased the total sulfhydryl content in kidneys. Here, we demonstrated for the first time that β-cyclodextrins, M-β-cyclodextrins, and HP-β-cyclodextrins cause bioenergetic dysfunction in renal and hepatic tissues. These findings suggest that understanding the balance between cyclodextrins’ efficacy and adverse effects is essential for better accepting their use in medicine.

https://doi.org/10.1590/0001-3765202320201783

13.

Benznidazole treatment decreases IL-6 levels in Trypanosoma cruzi-infected human adipocytes differentiated from adipose tissue-derived stem cells
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Moreira, Leyllane Rafael

; Silva, Ana Carla

; Costa Oliveira, Cíntia Nascimento da

; Silva Júnior, Claudeir Dias da

; Nascimento, Amanda Vasconcelos

; Oliveira, Kamila Kássia dos Santos

; Soares, Ana Karine de Araújo

; Saraiva, Karina Lidianne Alcântara

; Paiva Cavalcanti, Milena de

; Lorena, Virginia Maria Barros de

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220295

Resumo: En | Texto: En | PDF: En

BACKGROUND Trypanosoma cruzi, which causes Chagas disease (CD), is a versatile haemoparasite that uses several strategies to evade the host’s immune response, including adipose tissue (AT), used as a reservoir of infection. As it is an effective barrier to parasite evasion, the effectiveness of the drug recommended for treating CD, Benznidazole (BZ), may be questionable. OBJECTIVE To this end, we evaluated the parasite load and immunomodulation caused by BZ treatment in the culture of adipocytes differentiated from human adipose tissue-derived stem cells (ADSC) infected with T. cruzi. METHODS The ADSC were subjected to adipogenic differentiation. We then carried out four cultures in which we infected the differentiated AT with trypomastigote forms of the Y strain of T. cruzi and treated them with BZ. After the incubation, the infected AT was subjected to quantitative polymerase chain reaction (qPCR) to quantify the parasite load and transmission electron microscopy (TEM) to verify the infection. The supernatant was collected to measure cytokines, chemokines, and adipokines. FINDINGS We found elevated secretion of IL-6, CXCL-10/IP-10, CCL2/MCP-1, CCL5/RANTES, and leptin in infected fat cells. However, treatment with BZ promoted a decrease in IL-6. MAIN CONCLUSION Therefore, we believe that BZ has a beneficial role as it reduces inflammation in infected fat cells.

https://doi.org/10.1590/0074-02760220295

14.

Memórias de puérperas sobre a assistência de enfermeiros na gestação e puerpério
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Silva, Layla Santana Corrêa da

; Sales, Ana Paula de Assis

; Almeida, Rodrigo Guimarães dos Santos

; Teston, Ellen Ferraz

; Oliveira, Daiane Medina de

; Santana, Luciana Virginia de Paula e Silva

New Trends in Qualitative Research

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Set 2022, Volume 13 elocation e701

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: Introdução: A vivência da maternidade para mulheres primíparas é um momento de passagem e diz respeito a mudanças físicas e emocionais. Essa experiência precisa ser acolhida pelas equipes de saúde desde a Atenção Primária até a média e alta complexidade. Sendo assim, no pré-natal de risco habitual, o enfermeiro generalista e o enfermeiro obstetra devem estar nas equipes de cuidados mantendo a qualidade da assistência ao pré- natal, parto e puerpério. A atenção a mulher de forma humanizada pode contribuir para a vivência de um puerpério mais satisfatório. Objetivos: reconhecer as percepções de puérperas nas ações de cuidado recebidas por enfermeiros em um Hospital de Ensino. Métodos: estudo qualitativo, exploratório, realizado em um Hospital de Ensino Federal, vinculado a uma Universidade Pública. Compôs o grupo desse estudo 13 mulheres primíparas, que pariram seus filhos através de parto normal ou de cirurgia cesariana no segundo semestre de 2021. Foi realizada entrevista por plataforma Google Meet entre o 30º e 45º dia de pós-parto com a seguinte indagação: Conte para mim o que representa ser mulher e puérpera pela primeira vez? A Análise foi realizada pelo software Iramuteq (Interface R pous les Analyses Multidimensionnelles de Textes et de Questionnaries - Versão alpha 2) Resultados: o corpus das entrevistas gerou 308 Unidades de Contexto Elementar (UCE). A Classificação Hierárquica Descendente (CHD) reteve 254 UCE, com aproveitamento de 82,47% e cinco classes, o léxico mais frequente foi enfermeiro (a), com frequência de 23 citações nos segmentos dos textos. Conclusões: Foi possível reconhecer o enfermeiro, como profissional promotor de práticas humanizadas na assistência ao parto, pelo relato das participantes do acolhimento recebido no momento do parto e puerpério imediato.

Abstract: Introduction: The experience of motherhood for primiparous women is a moment of passage and concerns physical and emotional changes. This experience needs to be welcomed by health teams from primary care to medium and high complexity. Therefore, in the usual risk prenatal care, the generalist nurse and the obstetrician nurse must be in the care teams, maintaining the quality of prenatal, childbirth and postpartum care. The attention to women in a humanized way can contribute to the experience of a more satisfactory postpartum period. Objectives: to recognize the perceptions of puerperal women in the care actions given by nurses in a School Hospital. Methods: qualitative, exploratory study, carried out in a Federal School Hospital, linked to a public university. The group in this study was composed of 13 primiparous women, who gave birth to their children through normal delivery or cesarean section in the second half of 2021. An interview was carried out using the Google Meet platform between the 30th and 45th day postpartum with the following question: What does it mean to me to be a woman and a puerperal for the first time? The analysis was performed using the Iramuteq software (Interface R pous les Analyses Multidimensionnelles de Textes et de Questionnaires - Version 0.7 alpha 2) Results: the corpus of the 13 interviews generated 308 Elementary Context Units (ECU). The Descending Hierarchical Classification (CHD) retained 254 UCE, with an 82.47% success rate and five classes; the most frequent lexicon was nurse (a), with a frequency of 23 citations in the text segments. Conclusions: it was possible to recognize the nurse as a professional promoter of humanized practices in childbirth care, by the participants' reports about the reception received at the time of childbirth and the immediate postpartum period.

https://doi.org/10.36367/ntqr.13.2022.e701

15.

Uma metodologia para mapeamento de estratégias pedagógicas e modelos tecnológicos adotados no ensino remoto emergencial no Brasil e no mundo
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Lima, Manuella Aschoff Cavalcanti Brandão

; Costa, Rostand Edson Oliveira

; Maknamara, Marlécio

; Campos, Virgínia Pinto

; Sousa, Dênio Mariz Timóteo de

New Trends in Qualitative Research

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Ago 2022, Volume 12 elocation e680

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: O campo educacional nunca mais foi o mesmo desde que a pandemia de Covid-19 o impulsionou ao ensino remoto. Pesquisas e relatos de experiência forneceram importantes diagnósticos das transformações educativas em tempos de pandemia. Durante a Pandemia de Covid-19 foi fundamental que agentes educacionais públicos e privados tenham trabalhado para manter as atividades pedagógicas e didáticas durante a fase de isolamento. Este artigo aborda os procedimentos metodológicos de um estudo sobre o Uso de Recursos Tecnológicos para Ensino Remoto e Híbrido durante a Pandemia, focalizando as estratégias e métodos utilizados para viabilizar a intermediação tecnológica necessária para a implementação do ensino remoto emergencial em diferentes países. A intenção do referido estudo foi levantar, compilar e organizar informações para servir de referência e auxiliar na projeção e recomendação de um conjunto de modelos e estratégias potencialmente aplicáveis no cenário educacional público do Estado da Paraíba, Brasil. A questão norteadora dos procedimentos relatados no artigo foi: quais procedimentos metodológicos são necessários ao mapeamento de estratégias pedagógicas e modelos tecnológicos adotados no ensino remoto emergencial no Brasil e no mundo durante a pandemia de Covid-19? A metodologia foi desenvolvida segundo procedimentos de Revisão Sistemática da Literatura, incluindo os processos de busca, elegibilidade, coleta e extração de dados em seis passos. Os resultados incluem dados estatísticos da RSL, dados sobre os artigos localizados e não-classificados, além de informações quanto a terminologias, tipos de oferta e dimensões de diretividade pedagógica encontradas nos artigos selecionados. Conclui-se com a expectativa de prosseguir contribuindo com o debate metodológico em torno de estudos que subsidiem, doravante, avaliação dos desdobramentos tecnológicos e pedagógicos do Ensino Remoto e Híbrido em redes públicas de ensino.

Abstract: The educational field has never been the same since the pandemic of Covid-19 propelled him to remote teaching. Research and experience reports provided important diagnoses of educational transformations in pandemic times. During the Covid-19 Pandemic, it was essential that public and private educational agents worked to maintain teaching activities during the isolation phase. This article addresses the methodological procedures of a study on the Use of Technological Resources for Remote and Hybrid Teaching during the Pandemic, focusing on the strategies and methods used to enable the technological intermediation necessary for the implementation of emergency remote teaching. The intention of this study was to collect, compile and organize information to serve as a reference and assist in the projection and recommendation of a set of models and strategies potentially applicable in the educational scenario of the State of Paraíba, Brazil. The guiding question of the procedures reported in the article was: what methodological procedures are necessary to map pedagogical strategies and technological models adopted in emergency remote teaching in Brazil and in the world during the Covid-19 pandemic? The methodology was developed according to Systematic Literature Review procedures, including processes of search, eligibility, data collection and extraction in six steps. The results include statistical data from RSL, data on localized and unclassified articles, as well as information on terminology, types of offer and dimensions of pedagogical directiveness found in the selected articles. It concludes with the expectation of continuing to contribute to the methodological debate around studies that support, from now on, the evaluation of the technological and pedagogical developments of Remote and Hybrid Teaching in public networks.

https://doi.org/10.36367/ntqr.12.2022.e680

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