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ABSTRACT Objective: To evaluate smartphone addiction and postural alterations in the cervical region in adolescents. Methods: A cross-sectional study with 281 adolescents (15 to 19 years old), attending the 1st to the 3rd grades of High School, carried out between September and October 2019 in the city of Fortaleza, Ceará, Brazil. Data collection took place in two stages. In the first, they answered four self-administered questionnaires: sociodemographic questionnaire, health conditions and smartphone use, Nordic Musculoskeletal Symptom Questionnaire (NMQ), Self-Report Questionnaire (SRQ-20) and the Smartphone Addiction Inventory (SPAI-BR). In the second stage, they were submitted to photogrammetry using the Postural Assessment Software (SAPO) and anthropometric assessment (weight and height). The software SPSS Statistics version 23.0 was used for data analysis. Results: Of the total number of adolescents, 63.3% (n=178) showed smartphone addiction, using it for 5.8 hours (±3.5) during the week and 8.7 (±4.0) hours on the weekend. When analyzing postural alignment in the anterior view, a significant reduction in the lateral head tilt was observed when typing on the smartphone (p=0.002) compared to the anatomical position (baseline). In the lateral view, an increase in head anteriorization was observed during smartphone use (p<0.05). There was an association between smartphone addiction and head anteriorization (p<0.05). Conclusions: The use of the smartphone in the typing position causes postural alterations in the cervical region, especially in adolescents with smartphone addiction. Therefore, health promotion measures that alert adolescents to the adverse effects caused by prolonged smartphone use are necessary.

RESUMO Objetivo: Avaliar a dependência do smartphone e a alteração postural da região cervical em adolescentes. Métodos: Estudo transversal, com 281 adolescentes (15 a 19 anos), que frequentavam da 1ᵃ à 3ᵃ série do ensino médio, realizado entre setembro e outubro de 2019 na cidade de Fortaleza, Ceará, Brasil. A coleta dos dados ocorreu em duas etapas. Na primeira, eles responderam a quatro questionários autoaplicáveis: questionário sociodemográfico, condições de saúde e uso do smartphon e, Questionário Nórdico de Sintomas Musculoesqueléticos (NMQ), Self-Report Questi onnaire (SRQ-20) e o Smartphone A ddiction Inventory (SPAI-BR). Na segunda etapa, foram submetidos a fotogrametria pelo Software de Avaliação Postural (SAPO) e avaliação antropométrica (peso e altura). Para a análise dos dados, foi utilizado o SPSS Statistics versão 23.0. Resultados: Do total, 63,3% (n=178) dos adolescentes apresentaram dependência do smartphone, com o uso de 5,8 horas (±3,5) durante a semana e 8,7 (±4,0) no fim de semana. Ao analisar o alinhamento postural na visão anterior, observou-se redução significativa da inclinação lateral de cabeça ao digitar no smartphon e (p=0,002) comparado à posição anatômica (baseline). Na visão lateral foi constatado aumento da anteriorização de cabeça durante o uso do smartphon e (p<0,05). Houve associação da dependência do smartphone com a anteriorização de cabeça (p<0,05). Conclusões: O uso do smartphone na posição de digitação causa alteração postural na região cervical, destacadamente naqueles que apresentam dependência do dispositivo. Dessa forma, são necessárias medidas de promoção de saúde que alertem os adolescentes sobre os efeitos adversos causados pelo uso prolongado do smartphone.

https://doi.org/10.1590/1984-0462/2024/42/2023051

Analysis of the costs of the basic care line for sickle cell disease in Brazilian children under 5 years of age
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Motta, Franciane Vilela Réche Réche da

; Souza, Samara De Paula Silva

; Fonseca, Lucas Augusto Niess Soares

; Chaoubah, Alfredo

; Rodrigues, Daniela de Oliveira Werneck

Hematology, Transfusion and Cell Therapy

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Jul 2023, Volume 45 Supl. 2 Páginas S113 - S118

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To evaluate and estimate the cost of basic care in sickle cell disease (SCD) for patients under five years of age, within the scope of the Unified Health System (SUS) and to discuss the costs related to possible complications of the disease from the literature. Methods: The main management and conduct recommendations in the SCD up to five years of age, with healthy and baseline health status, were extracted from the Basic Guidelines of the Care Line in the SCD of the Ministry of Health. Systematic data regarding costs of medicines were extracted from the Medicine Market Regulation Chamber. The SUS Table of Procedures, Medicines and Orthotics, Prosthetics and Auxiliary Means of Movement Management System was the guide for the values of complementary exams, as well as for medical consultations. The values applied to calculate the vaccination schedule were extracted from the Pan American Health Organization, adopting the perspective of the SUS-paying costs. Results: The total cost obtained for basic care of SCD in children up to five years of age, including the use of antibiotic prophylaxis, immunizations and the performance of transcranial Doppler ultrasound in the prevention and early detection of cerebrovascular accidents was, on average, $1020.96. Conclusion: The cost-effectiveness of prophylaxis in SCD, up to five years of age, exceeds the expenses resulting from hospitalizations due to complications of the disease. The study of expenses associated with SCD could be used to establish public policies, improve prevention strategies and treat the symptoms and complications of the disease.

https://doi.org/10.1016/j.htct.2022.09.1184

Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19
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Barbosa, Hannah Cardoso

; Martins, Maria Auxiliadora Parreiras

; Jesus, Jordana Cristina de

; Meira, Karina Cardoso

; Passaglia, Luiz Guilherme

; Sacioto, Manuela Furtado

; Bezerra, Adriana Falangola Benjamin

; Schwarzbold, Alexandre Vargas

; Maurílio, Amanda de Oliveira

; Farace, Barbara Lopes

; Silva, Carla Thais Cândida Alves da

; Cimini, Christiane Corrêa Rodrigues

; Silveira, Daniel Vitorio

; Carazai, Daniela do Reis

; Ponce, Daniela

; Costa, Emanuel Victor Alves

; Manenti, Euler Roberto Fernandes

; Cenci, Evelin Paola de Almeida

; Bartolazzi, Frederico

; Madeira, Glícia Cristina de Castro

; Nascimento, Guilherme Fagundes

; Velloso, Isabela Vasconcellos Pires

; Batista, Joanna d’Arc Lyra

; Morais, Júlia Drumond Parreiras de

; Carvalho, Juliana da Silva Nogueira

; Ruschel, Karen Brasil

; Martins, Karina Paula Medeiros Prado

; Zandoná, Liege Barella

; Menezes, Luanna Silva Monteiro

; Kopittke, Luciane

; Castro, Luís César de

; Nasi, Luiz Antônio

; Floriani, Maiara Anschau

; Souza, Maíra Dias

; Carneiro, Marcelo

; Bicalho, Maria Aparecida Camargos

; Lima, Maria Clara Pontello Barbosa

; Godoy, Mariana Frizzo de

; Guimarães-Júnior, Milton Henriques

; Mendes, Paulo Mascarenhas

; Delfino-Pereira, Polianna

; Ribeiro, Raquel Jaqueline Eder

; Finger, Renan Goulart

; Menezes, Rochele Mosmann

; Francisco, Saionara Cristina

; Araújo, Silvia Ferreira

; Oliveira, Talita Fischer

; Oliveira, Thainara Conceição de

; Polanczyk, Carisi Anne

; Marcolino, Milena Soriano

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 2 elocation e20220151

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.

Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19.

https://doi.org/10.36660/abc.20220151

Acquired enamel pellicle protects gastroesophageal reflux disease patients against erosive tooth wear
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MARTINI, Tatiana

; RIOS, Daniela

; DIONIZIO, Aline

; CASSIANO, Luiza de Paula Silva

; SILVA, Cíntia Maria de Souza e

; TAIRA, Even Akemi

; VENTURA, Talita Mendes Oliveira

; CÂMARA, João Victor Frazão

; Araujo, Tamara Teodoro

; MAGALHÃES, Ana Carolina

; CARVALHO, Thiago Saads

; BAUMANN, Tommy

; LUSSI, Adrian

; OLIVEIRA, Ricardo Brandt de

; PALMA-DIBB, Regina Guenka

; BUZALAF, Marília Afonso Rabelo

Brazilian Oral Research

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2023, Volume 37 elocation e085

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to compare the protein profile of the acquired enamel pellicle (AEP) formed in vivo in patients with or without gastroesophageal reflux disease (GERD), and with or without erosive tooth wear (ETW). Twenty-four volunteers were divided into 3 groups: 1) GERD and ETW; 2) GERD without ETW; and 3) control (without GERD). The AEP formed 120 min after prophylaxis was collected from the lingual/palatal surfaces. The samples were subjected to mass spectrometry (nLC-ESI-MS/MS) and label-free quantification by Protein Lynx Global Service software. A total of 213 proteins were identified, or 119, 92 and 106 from each group, respectively. Group 2 showed a high number of phosphorylated and calcium-binding proteins. Twenty-three proteins were found in all the groups, including 14-3-3 protein zeta/delta and 1-phosphatidylinositol. Several intracellular proteins that join saliva after the exfoliation of oral mucosa cells might have the potential to bind hydroxyapatite, or participate in forming supramolecular aggregates that bind to precursor proteins in the AEP. Proteins might play a central role in protecting the dental surface against acid dissolution.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0085

Deep sea ecosystem exploration and ‘health check’: sampling strategy and methods applied during the iAtlantic_BR10_Petrobras cruise in the Santos Basin, Southwest Atlantic
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Perez, Jose Angel A.

; Barros Neto, Halésio M.C. de

; Arantes, Renata C.M.

; Gaurisas, Daniela Y.

; Silva, Camila F.

; Alves, Fernanda Maria M.

; Costa, Júlia A.

; Eloi, Paula D.C.

; Fonseca, Thayse S.

; Gavazzoni, Lucas

; Lonskis, Isabella da S.

; Nardi, Ricardo U.

; Nascimento, Pedro O.

; Rodrigues, João Vitor M.

; Santos, Ana Lara F. dos

; Santos, Edson C. dos

; Schroeder, Rafael

; Silva, Luis Carlos da

; Souza, Fernanda dos S.S. de

; Bernardino, Ângelo F.

; Cavalcanti, Guarani H.

; Lindner, Alberto

; Mahiques, Michel M. de

; Millo, Christian

; Reis, Priscila

; Sweetman, Andrew K.

; Roberts, J. Murray

Ocean and Coastal Research

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2023, Volume 71 elocation e23046

Resumo: En | Texto: En | PDF: En

Abstract The iAtlantic Project has established an international collaborative strategy to improve mapping and characterization of deep and open ocean ecosystems in understudied regions of the Atlantic and evaluate their health. In December 2022, the first iAtlantic expedition in the South Atlantic set off to map and explore seafloor ecosystems in the Santos Basin slope (200-1,000 m depths) in collaboration with the Petrobras ‘Santos Basin - Regional Characterization Project.’ The 17-day ‘iAtlantic_BR10-Petrobras’ cruise was conducted on board the research vessel NPqHOc Vital de Oliveira (Brazilian Navy) and performed (a) water column structure characterization, (b) seafloor morphology mapping, (c) description of benthic habitats and communities by seafloor imagery and biological/ geological sampling, and (d) ex-situ experiments to assess the functioning of sedimentary ecosystems and their responses to climate-related environmental changes. This study describes the rationale behind the iAtlantic_BR10-Petrobras cruise science plan, reports its sampling strategy and methods, and summarizes its collected data and preliminary results.

https://doi.org/10.1590/2675-2824071.23069jaap

USTEKINUMAB IN CROHN’S DISEASE MANAGEMENT: A BRAZILIAN OBSERVATIONAL STUDY
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CASTRO, Paula Cenira Senger de

; MAGRO, Daniéla Oliveira

; NONES, Rodrigo Bremer

; FURLAN, Thaisa Kowalski

; MIRANDA, Eron Fábio

; KOTZE, Paulo Gustavo

Arquivos de Gastroenterologia

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Dez 2022, Volume 59 Nº 4 Páginas 501 - 507

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Background: Real-world data on the use of Ustekinumab (UST) in Brazilian and Latin American patients with Crohn’s disease (CD) are scarce. Objective: The primary endpoint was assessment of clinical remission at weeks 8 and 52, and secondary endpoints were: assessment of clinical response at weeks 8 and 52, endoscopic remission, adverse events, and rates of CD-related abdominal surgery during follow-up. Methods: observational and retrospective study, including patients with CD treated at two centers, who received UST at any time during their treatment. Remission and clinical response were defined as a Harvey-Bradshaw index ≤4 and ≥3 points reduction, respectively. Results: Seventy-four patients were included, 85.1% previously exposed to anti-TNFs. Clinical remission was observed in 45.8% and 59.4% of patients at weeks 8 and 52, respectively. The clinical response rates were 54.2% and 67.6% at weeks 8 and 52. Endoscopic remission was observed in 21.8% of patients. Seventeen patients had adverse events, mostly mild infections, with 22.9% of patients undergoing abdominal surgery (ileocolectomy being the most common procedure). Conclusion UST therapy resulted in significant rates of remission and clinical response, as described in other real-world studies. Few patients had adverse events during treatment, showing its adequate safety profile.

RESUMO Contexto: Dados de vida real sobre o uso de Ustequinumabe (UST) em pacientes brasileiros e latino-americanos com doença de Crohn (DC) são escassos. Objetivo: O desfecho primário foi a avaliação da remissão clínica nas semanas 8 e 52, e os desfechos secundários foram: avaliação da resposta clínica nas semanas 8 e 52, remissão endoscópica, eventos adversos e taxas de cirurgia abdominal relacionada à DC durante o seguimento. Métodos: Estudo observacional e retrospectivo, incluindo pacientes com DC tratados em dois centros, que receberam UST em qualquer momento do tratamento. A remissão e a resposta clínica foram definidas como índice de Harvey-Bradshaw ≤4 e ≥3 pontos de redução, respectivamente. Resultados: Foram incluídos 74 pacientes, 85,1% previamente expostos a anti-TNFs. A remissão clínica foi observada em 45,8% e 59,4% dos pacientes nas semanas 8 e 52, respectivamente. As taxas de resposta clínica foram de 54,2% e 67,6% nas semanas 8 e 52. A remissão endoscópica foi observada em 21,8% dos pacientes. Dezessete pacientes apresentaram eventos adversos, principalmente infecções leves, sendo 22,9% dos pacientes submetidos à cirurgia abdominal (sendo a ileocolectomia o procedimento mais comum). Conclusão: A terapia com UST resultou em taxas significativas de remissão e resposta clínica, conforme descrito em outros estudos do mundo real. Poucos pacientes apresentaram eventos adversos durante o tratamento, mostrando seu adequado perfil de segurança.

https://doi.org/10.1590/s0004-2803.202204000-89

Comparison of the autonomic nervous system dysfunction between different chronic spine disorders: neck pain versus low back pain
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Pontes-Silva, André

; Bassi-Dibai, Daniela

; Fidelis-de-Paula-Gomes, Cid André

; Souza, Cesário da Silva

; Pires, Flavio de Oliveira

; Mostarda, Cristiano Teixeira

; Dibai Filho, Almir Vieira

Revista da Associação Médica Brasileira

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Set 2022, Volume 68 Nº 9 Páginas 1288 - 1296

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: This study aims to compare heart rate variability (HRV) between patients with chronic neck pain and patients with chronic low back pain and to correlate the chronic pain variables with heart rate variability indices. METHODS: This is a cross-sectional study. We divided the sample into two groups: neck pain (n=30) and low back pain (n=30). We used the Numeric Pain Rating Scale, Neck Disability Index, Roland-Morris Disability Questionnaire, Pain-Related Catastrophizing Thoughts Scale, Tampa Scale of Kinesiophobia, and Pain Self-Efficacy Questionnaire. For heart rate variability analysis, we used the following indices: mean RR, standard deviation of all RR intervals, mean heart rate, root mean square differences of successive RR intervals, triangular index, triangular interpolation of the interval histogram, low-frequency band in arbitrary units and in absolute values, high-frequency band in arbitrary units and in absolute values, standard deviation of the instantaneous beat-to-beat variability (standard deviation 1), long-term standard deviation of continuous RR intervals (standard deviation 2), and Stress Index. We used Student’s t-test for comparisons and Spearman’s coefficient for correlations. RESULTS: We observe insignificant values in the differences between the groups. Disability and self-efficacy were correlated with heart rate variability only in patients with chronic neck pain, whereas catastrophizing and kinesiophobia showed greater correlations with heart rate variability in patients with chronic low back pain. CONCLUSIONS: Autonomic dysfunction of individuals with chronic neck pain, when compared to patients with chronic low back pain, does present insignificant differences.

https://doi.org/10.1590/1806-9282.20220406

The possible mediating relationship promoted by the self-efficacy of breastfeeding associated with the Kangaroo Method on indicators of exclusive breastfeeding
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Souza, Rayany Cristina de

; Wolkers, Paula Carolina Bejo

; Pereira, Leandro Alves

; Romão, Rejane Sousa

; Medeiros, Eliziane Santos

; Ferreira, Daniela Marques de Lima Mota

; Rinaldi, Ana Elisa Madalena

; Azevedo, Vivian Mara Gonçalves de Oliveira

Jornal de Pediatria

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Set 2022, Volume 98 Nº 5 Páginas 540 - 544

Resumo: En | Texto: En | PDF: En

Abstract Objective Assess the mediating role of breastfeeding self-efficacy in the association between the Kangaroo Neonatal Intermediate Care Unit and exclusive breastfeeding. Method Cross-sectional study nested in a cohort, carried out in the Neonatal Unit of a Brazilian university hospital between September 2018 and March 2020. The sample consisted of 114 newborns weighing ≤1800 g and their mothers who were divided into those who participated in the first and second stages of the Kangaroo Method and those who only passed through the first stage, categorized as the Conventional group. To assess the self-efficacy of breastfeeding, the Breastfeeding Self Efficacy Scale - Short-Form was used. The Mann-Whitney test was used to compare the breastfeeding self-efficacy score between the groups, and Fisher's exact test to compare rates of exclusive breastfeeding. The adjusted structural equation model was used to check for the mediating effect of breastfeeding self-efficacy. The significance level adopted was 5%. Results The kangaroo group had a higher rate of exclusive breastfeeding at hospital discharge (p= 0.000). There was a positive association between having remained in the kangaroo (p= 0.003) and the breastfeeding self-efficacy score (p= 0.025) with the rate of exclusive breastfeeding at hospital discharge. Breastfeeding self-efficacy did not act as a mediator. Conclusion The self-efficacy of breastfeeding and the stay of the low birth weight newborn baby in the kangaroo unit acted positively and independently in exclusive breastfeeding, and the self-efficacy of breastfeeding did not act as a mediator in this association.

https://doi.org/10.1016/j.jped.2021.12.011

Fatores de risco nas neurocirurgias: um estudo de coorte no norte do Brasil
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de Araújo, Laís Xavier

; Perez da Silva Pereira, Priscilla

; Cantanhede de Deus, Josimeire

; Oliveira Pontes, Daniela

; Tavares Hang, Adriana

; Gadelha Freitas, Jeanne Lúcia

; Moreira da Silva, Valéria

; de Paula Paiva, Karla

; Moura de Souza, Caren Juliana

; Suaris Meireles, Carla Vanessa

; Delfino Rodrigues, Mariana

; da Silva Tavares, Daniella Thamara

; Sanches Rosa, Marcela Miranda

Revista Cuidarte

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Ago 2022, Volume 13 Nº 2 elocation e10

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Introdujo: Pacientes neurocirúrgicos apresentam elevado risco de complicates locais e sistemicas que podem aumentar o tempo de internado e o risco de morte. Este estudo tem como objetivo avaliar a incidencia de infectes relacionadas a assistencia a saúde e os fatores de risco associados em pacientes submetidos as neurocirurgias. Materiais e Métodos: Estudo de coorte prospectiva, realizado em um Hospital de grande porte do estado de Rondonia, no período de 2018 a 2019, incluindo 36 pacientes. Resultados: A incidencia de infectes relacionada a assistencia a saúde foi 19,4 a cada 100 pacientes (IC95%: 8,19 - 36,02). Ter utilizado sonda nasoenteral aumentou em 6,5 vezes o risco de IRAS (IC 95%: 1,26 - 33,5), a ventilagáo mecánica aumentou 5,52 vezes o risco (IC95%: 1,23 - 24,6), a presenta de traqueostomia aumentou seis vezes (IC95%: 1,34 - 26,8) e realizagáo de exame invasivo aumentou o risco em 6,79 para ter infecto (IC95%: 1,31 - 35,05). Na análise ajustada as variáveis náo apresentaram significáncia estatística. Discussao: A incidencia de infectes foi maior do que em regióes com melhores condigóes socioeconómicas o que pode estar relacionado a menor adesáo de boas práticas na assistencia. Conclusao: Nas neurocirurgias além das infecgóes de sítio cirúrgico outras topografias também devem ser consideradas para investigagáo de infecgáo. O uso de dispositivos invasivos foi associado a ocorrencia de infecgóes relacionadas a assistencia a saúde, portanto as boas práticas no seu uso sáo essenciais no momento da indicagáo e uso destes dispositivos.

Abstract Introduction: Neurosurgical patients are at high risk of local and systemic complications that can increase the length of stay and the risk of death. This study aims to assess the incidence of healthcare-related infections and associated risk factors in patients undergoing neurosurgery. Materials and Methods: prospective cohort study, carried out in a large hospital in the state of Rondonia, in the period from 2018 to 2019, including 36 patients. Results: The incidence of healthcare-related infections was 19.4 per 100 patients (95% CI: 8,19 - 36,02). The use of nasoenteral tube increased the risk of HAI by 6.5 times (95% CI: 1,26 - 33,5), mechanical ventilation increased 5.52 times the risk (95% CI: 1,23 - 24,6), the presence of tracheostomy increased six times (95% CI: 1.34 - 26.8) and invasive examination increased the risk by 6.79 to have infection (95% CI: 1,31 - 35,05). In the adjusted analysis, the variables were not statistically significant. Discussion: The incidence of infections was higher than in regions with better socioeconomic conditions, which may be related to lower adherence to good care practices. Conclusion: in neurosurgeries, in addition to surgical site infections, other topographies should also be considered for investigation of infection. The use of invasive devices has been associated with the occurrence of healthcare-related infections, so good practices in their use are essential when referring and using these devices.

Resumen Introducción: Los pacientes neuroquirúrgicos tienen un alto riesgo de complicaciones locales y sistémicas que pueden aumentar la duración de la estancia y el riesgo de muerte. Este estudio tiene como objetivo evaluar la incidencia de infecciones relacionadas con la atención médica y los factores de riesgo asociados en pacientes sometidos a neurocirugía. Materiales y métodos: estudio de cohorte prospectivo, realizado en un gran hospital del estado de Rondonia, en el período de 2018 a 2019, incluyendo 36 pacientes. Resultados: La incidencia de infecciones relacionadas con la asistencia sanitaria fue de 19,4 por 100 pacientes (IC del 95%: 8,19 - 36,02). Haber utilizado una sonda nasoenteral aumentó el riesgo de infecciones en 6,5 veces (IC 95%: 1,26 - 33,5), la ventilación mecánica aumentó 5,52 veces el riesgo (IC 95%: 1, 23 - 24,6), la presencia de traqueotomía aumentó seis veces (IC del 95%: 1,34 - 26,8) y el examen invasivo aumentó el riesgo en 6,79 de tener infecciones (IC del 95%: 1,31 - 35,05). En el análisis ajustado, las variables no fueron estadísticamente significativas. Discusión: La incidencia de infecciones fue mayor que en las regiones con mejores condiciones socioeconómicas, lo que puede estar relacionado con una menor adherencia a las buenas prácticas de atención. Conclusión: en neurocirugía, además de las infecciones del sitio quirúrgico, también deben considerarse otras topografías para la investigación de la infección. El uso de dispositivos invasivos se ha asociado con la aparición de infecciones relacionadas con la salud, por lo que las buenas prácticas en su uso son fundamentales a la hora de derivar y utilizar estos dispositivos.

https://doi.org/10.15649/cuidarte.2154 2 downloads

10.

Psychological Factors in Temporomandibular Disorders Patients during COVID-19 Pandemic: A Cross-Sectional Study
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Rocha, Thaís de Oliveira

; Oliveira, Wagner de

; Paula, Ângela Renata de

; Oliveira, Daniela Lobo

; Rode, Sigmar de Mello

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2022, Volume 22 elocation e200246

Resumo: En | Texto: En | PDF: En

Abstract Objective: To assess the influence of the COVID-19 pandemic on levels of anxiety, stress, and orofacial pain in individuals with and without TMD. Material and Methods: In this cross-sectional study, the participants were divided into two groups (n=10, each) experimental group (EG) TMD patients and control group (CG), without TMD. The presence of TMD was confirmed using the RDC/TMD. The Beck Anxiety Scale (BAI), Perceived Stress Scale (PSS), and Oral Analog Scale were used for assessment. The Beck Anxiety Scale is composed of 21 multiple-choice questions describing symptoms of anxiety, while the PSS is a measure that evaluates life situations as stressful. An Oral Analogue Scale was applied to each individual to quantify orofacial pain, with 0 (zero) without pain and 10 (ten) being the worst pain ever felt. The comparison between groups was performed using the Mann-Whitney test. Logistic regression was used to verify TMD dependence in relation to BAI and PSS-10. Quantitative variables were correlated with each other by Pearson's correlation coefficient. The level of significance considered for all tests was 5%. Results: The association was statistically significant (p≤0.05) for BAI and PSS with a TMD. Conclusion: Although the COVID 19 pandemic has had a psychological impact on the general population, patients with TMD have higher levels of anxiety and stress than the control group.

https://doi.org/10.1590/pboci.2022.020

11.

Factors associated with the incidence of pressure wounds in critical patients: a cohort study
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Teixeira, Andreza de Oliveira

; Brinati, Lídia Miranda

; Toledo, Luana Vieira

; Silva Neto, José Faustino da

; Teixeira, Daniela Lucas de Paula

; Januário, Carla de Fátima

; Silva Neto, Letícia Marques da

; Salgado, Patrícia de Oliveira

Revista Brasileira de Enfermagem

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2022, Volume 75 Nº 6 elocation e20210267

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: identificar a incidência de lesão por pressão em pacientes críticos e os fatores associados à sua ocorrência. Métodos: estudo de coorte retrospectiva, baseando-se na análise dos prontuários de 369 pacientes críticos. Utilizou-se estatística descritiva e inferencial, com regressão logística. Resultados: a incidência de lesão por pressão foi de 11,4%. Pacientes com internação por mais de quatro dias (OR 2,99; IC95% 1,15-7,78), em uso de cateter nasoentérico (OR: 3,81; IC95%: 1,4010,38), cateter vesical de demora (OR: 4,78; IC95%: 1,31-17,38) e traqueostomia (OR: 3,64; IC95%: 1,48-8,97) apresentaram maior chance de desenvolver lesão por pressão. A pontuação média da escala de Braden entre os pacientes que desenvolveram (14,2 pontos) ou não (12,3 pontos) lesão por pressão foi estatisticamente diferente (p<0,001). Conclusões: a incidência de lesão por pressão esteve associada ao maior tempo de permanência na unidade, utilização de cateter nasoentérico, cateter vesical de demora e traqueostomia.

ABSTRACT Objectives: to identify the incidence of pressure wound in critical patients and its associated factors. Methods: retrospective cohort study, based on the analysis of 369 critical patients’ records. Descriptive and inferential statistics were used, as well as logistic regression. Results: the incidence of pressure wounds was 11.4%. Patients who had been hospitalized for four days or more (OR 2.99; CI95% 1.15-7.78), used nasoenteric tubes (OR: 3.81; CI95%: 1.4010.38), vesical drainage catheters (OR: 4.78; CI95%: 1.31-17.38) and tracheostomy (OR: 3.64; CI95%: 1.48-8.97) had a higher chance of developing pressure wounds. The mean score of the Braden scale among participants who developed (14.2 points) pressure wounds was statistically different (p<0.001) than that of those who did not (12.3 points). Conclusions: the incidence of pressure wounds was associated with a higher time in the unit, the use of nasoenteric tubes, vesical drainage catheters, and tracheostomies were associated with a higher time of hospitalization in the unit.

RESUMEN Objetivos: identificar la incidencia de úlcera por presión en pacientes críticos y los factores relacionados a su ocurrencia. Métodos: estudio de cohorte retrospectivo, basándose en el análisis de los prontuarios de 369 pacientes críticos. Se utilizó estadística descriptiva e inferencial, con regresión logística. Resultados: la incidencia de úlcera por presión fue de 11,4%. Pacientes con internación por más de cuatro días (OR 2,99; IC95% 1,15-7,78), en uso de catéter nasoenteral (OR: 3,81; IC95%: 1,40-10,38), catéter vesical de demora (OR: 4,78; IC95%: 1,31-17,38) y traqueostomía (OR: 3,64; IC95%: 1,48-8,97) presentaron mayor chance de desenvolver úlcera por presión. La puntuación mediana de la escala de Braden entre los pacientes que desarrollaron (14,2 puntos) o no (12,3 puntos) úlcera por presión fue estadísticamente diferente (p<0,001). Conclusiones: la incidencia de úlcera por presión estuvo relacionada al mayor tiempo de permanencia en la unidad, utilización de catéter nasoenteral, catéter vesical de demora y traqueostomía.

https://doi.org/10.1590/0034-7167-2021-0267

12.

Digestibility, performance and economic efficiency of diets containing phytase and distillers dried grains with solubles for growing pigs
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Corassa, Anderson

; Silva, Daniela Rocha da

; Ton, Ana Paula Silva

; Kiefer, Charles

; Sbardella, Maicon

; Brito, Claudson de Oliveira

; Teixeira, Alexandre de Oliveira

; Rothmund, Vivian Luana

Revista Brasileira de Saúde e Produção Animal

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2022, Volume 23 elocation e20220009

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Este estudo objetivou avaliar os efeitos da enzima fitase e dos grãos secos de destilaria com solúveis (distillers dried grains with solubles - DDGS) sobre digestibilidade, desempenho e viabilidade econômica de suínos em crescimento. Foram realizados dois experimentos, com uma dieta de referência (RD) à base de milho e farelo de soja; RD + 200 g kg -1 DDGS (DDGS); RD + 1.000 unidades de fitase (PHY); e RD + 200 g kg -1 DDGS + 1.000 unidades de fitase (D + P). No experimento 1, oito suínos machos castrados com peso de 29,35 ± 5,74 kg foram usados através do método de coleta total, com repetição no tempo para avaliação da digestibilidade. No experimento 2, 40 suínos machos castrados 47,65 ± 3,99 kg, com cinco repetições de dois animais por unidade experimental foram usados para avaliação de desempenho e viabilidade econômica. DDGS aumentou a excreção de nitrogênio e energia nas fezes e na urina, prejudicando os coeficientes de digestibilidade e a metabolizabilidade da energia. Os animais que consumiram dietas com DDGS apresentaram pior desempenho enquanto a fitase não afetou os resultados. As dietas com a inclusão de 200 g kg -1 DDGS e 1.000 unidades de fitase não diferem no custo por quilograma em relação à dieta de controle.

ABSTRACT This study aimed to evaluate the effects of phytase enzyme and distillers dried grains with solubles (DDGS) on the digestibility, performance and economic viability of growing pigs. Two experiments were conducted with a reference diet (RD) based on corn and soybean meal: RD with 200 g kg -1 DDGS (DDGS); RD + 1,000 units of phytase (PHY); and RD + 200 g kg-1 DDGS + 1,000 units of phytase (D+P). In experiment 1, eight castrated male pigs weighing 29.35 ± 5.74 kg were used through the total collection method and replicates in time for digestibility evaluation. In experiment 2, 40 castrated male pigs 47.65 ± 3.99 kg, with five replicates of two animals per experimental unit, were used for performance and economic evaluation. DDGS increased the excretion of nitrogen and energy in feces and urine, impairing the digestibility coefficients and metabolizability of dietary energy. The animals that consumed diets with DDGS presented the worst performance, while phytase did not influence the results. Diets with the inclusion of 200 g kg -1 DDGS and 1,000 units of phytase did not differ in cost per kilogram compared to the control diet.

https://doi.org/10.1590/s1519-9940202200092022

13.

Tempo de uso do smartphone e condições de saúde relacionadas em idosos durante a pandemia da covid-19
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Abdon, Ana Paula Vasconcellos

; Barros, Monike Couras Del Vecchio

; Abreu, Camila Cristine Tavares

; Falcão, Thais Nogueira

; Sousa, João Gabriel de Oliveira e

; Mont'Alverne, Daniela Gardano Bucharles

Revista Brasileira de Geriatria e Gerontologia

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2022, Volume 25 Nº 6 elocation e210194

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Avaliar o tempo de uso do smartphone e as condições de saúde relacionadas em idosos durante a pandemia da covid-19. Método Trata-se de estudo transversal com 237 idosos (≥60 anos) brasileiros, realizado entre junho e agosto de 2020. Responderam a um formulário on-line para obtenção das seguintes variáveis: perfil socioeconômico, condições de saúde e uso do smartphone. Análises bivariada e multivariada foram realizadas pelo programa SPSS, tendo como desfecho tempo de uso do smartphone. Resultados Do total, 69,2% (n=164) eram do sexo feminino, 48,5% (n=115) queixavam-se de dor cervical, 57,4% (n=136) tinham incapacidade cervical e permaneciam 6,2 horas por dia sentados na semana. Cerca de 54,4% (n=129) relataram aumento do uso do smartphone nos últimos meses, passando 4,2 horas/dia. Os idosos mais novos (p=0,038), não praticantes de atividade física (p=0,001), com avaliação de saúde boa (p=0,009) e maior tempo sentado (p=0,011) permaneciam mais tempo usando o dispositivo. Conclusão Devido ao uso do smartphone durante a pandemia da covid-19 associado a maior tempo sentado e ao sedentarismo alerta-se para as repercussões negativas na saúde física e mental dos idosos.

Abstract Objective To evaluate smartphone usage time and related health conditions in older people during the COVID-19 pandemic. Method This is a cross-sectional study of 237 older people (aged ≥60 years) Brazilians, carried out between June and August 2020. An online form was used to obtain the following variables: socio-economic profile, health status, and smartphone usage. Bivariate and multivariate analyzes were performed using the SPSS program with the outcome of smartphone usage time. Results Of the study individuals, 69.2% (n=164) were females, 48.5% (n=115) complained of cervical pain, 57.4% (n=136) had a cervical disability and remained 6.2 hours a day in the sitting position per week. Approximately 54.4% (n=129) reported increased smartphone usage in the past few months, reporting 4.2 hours of usage/day. Younger senior individuals (p=0.038), who did not practice physical activities (p=0.001), with good health assessment (p=0.009) and who spent more extended periods in the sitting position (p=0.011) spent more time using the device. Conclusion Considering the smartphone usage during the COVID-19 pandemic associated with more extended periods in the sitting position and a sedentary lifestyle, it is worth mentioning its adverse effects on the physical and mental health of older people.

https://doi.org/10.1590/1981-22562022025.210194.pt

14.

Evaluation of respiratory complications in a cohort of preterm infants who did not receive palivizumab monoclonal antibodies
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Bonati, Poliana Castro de Resende

; Furtado, Maria Cândida de Carvalho

; Mello, Débora Falleiros de

; Wolkers, Paula Carolina Bejo

; Faria, Gabriel de Oliveira

; Ferreira, Daniela Marques de Lima Mota

Revista Brasileira de Enfermagem

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2022, Volume 75 Nº 6 elocation e20210362

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: investigar intercorrências respiratórias no primeiro ano de vida de prematuros não contemplados com anticorpo monoclonal palivizumabe. Métodos: estudo de coorte retrospectivo, analítico, com prematuros nascidos entre 2012 e 2016, em Uberlândia, MG. Coleta realizada de janeiro a novembro de 2018, em prontuários hospitalar e da atenção básica. Utilizou-se modelo de regressão de Poisson; considerou-se p<0.05. Resultados: de 5.213 nascimentos prematuros, 504 (9,7%) atenderam os critérios; esses prematuros tiveram 2.899 atendimentos na atenção básica; 1.098 (37,5%) com diagnóstico médico, 803 (78,5%) do trato respiratório. Prematuros com fórmula láctea na alta hospitalar tiveram mais diagnósticos de doenças respiratórias. Idade materna (p=0,039), diagnóstico respiratório na alta (p=0,028), número de consultas eventuais (p<0,001) apresentaram associação significativa com bronquiolite. Consultas eventuais foram significantes para doenças respiratórias; o aleitamento materno mostrou-se protetor para bronquiolite. Conclusões: prematuros sem palivizumabe apresentaram elevado percentual de doenças respiratórias; observou-se efeito protetor do aleitamento materno. Recomenda-se vigilância desses prematuros na atenção primária.

ABSTRACT Objectives: to analyze the occurrence of respiratory complications over the first year of life in preterm infants who did not receive palivizumab monoclonal antibodies. Methods: analytical retrospective cohort study with preterm infants born between 2012 and 2016 in Uberlândia, state of Minas Gerais, Brazil. Data collection occurred from January to November 2018, by consulting hospital and primary healthcare medical records. Data were processed with the Poisson regression model, with p<0.05. Results: of a total of 5,213 preterm births, 504 (9.7%) met the inclusion criteria. The preterm infants in this subset were assisted 2,899 times in primary care, which resulted in 1,098 (37.5%) medical diagnoses, of which 803 (78.5%) involved the respiratory tract. Preterm babies fed on formula milk at hospital discharge had more diagnoses of respiratory diseases. Maternal age (p=0.039), respiratory diagnosis at hospital discharge (p=0.028), and number of sporadic appointments (p<0.001) showed a significant association with bronchiolitis; number of sporadic appointments showed a significant association with occurrence of respiratory diseases; and breastfeeding had a protective effect against the development of bronchiolitis. Conclusions: preterm infants who did not receive palivizumab showed a high percentage of respiratory diseases, and breastfeeding helped protect them against bronchiolitis. It is recommended that these preterm babies be monitored in primary health care.

RESUMEN Objetivos: investigar complicaciones respiratorias en el primer año de vida de prematuros no contemplados con anticuerpo monoclonal palivizumab. Métodos: estudio de cohorte retrospectivo, analítico, con prematuros nacidos entre 2012 y 2016 en Uberlândia, MG. Datos recolectados de enero a noviembre de 2018 en historias clínicas hospitalarias y de atención básica. Se utilizó modelo de regresión de Poisson, considerándose p<0,05. Resultados: de 5.513 nacimientos prematuros, 504 (9,7%) atendieron criterios; estos prematuros recibieron 2.899 consultas en atención básica; 1.098 (37,5%) con diagnóstico médico; 803 (78,5%) del tracto respiratorio. Prematuros con fórmula láctea al alta hospitalaria recibieron más diagnósticos de enfermedades respiratorias. Edad materna (p=0,039), diagnóstico respiratorio al alta (p=0,028), cantidad de consultas eventuales (p<0,001) mostraron asociación significativa con bronquiolitis. Conclusiones: prematuros sin palivizumab mostraron elevado porcentaje de enfermedades respiratorias; se observó efecto protector de la lactancia materna. Se recomienda el seguimiento de dichos prematuros en atención primaria.

https://doi.org/10.1590/0034-7167-2021-0362

15.

Segurança do Agente de Contraste SF6 (SonoVueⓇ) no Ecocardiograma sob Estresse Farmacológico
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Furtado, Rogerio Gomes

; Rassi, Daniela do Carmo

; Melato, Luciano Henrique

; Oliveira, Ana Caroline Reinaldo de

; Nunes, Paula Meneses

; Baccelli, Priscila Elias

; Santos, Sara Camila de Oliveira

; Santos, Victor Emanuel

; Rassi Junior, Luiz

; Nunes, Colandy Godoy

Arquivos Brasileiros de Cardiologia

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Dez 2021, Volume 117 Nº 6 Páginas 1170 - 1178

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento Em 2007, a Food and Drug Administration (FDA) determinou revisões sobre segurança dos agentes de contraste ecocardiográfico (ACE) disponíveis no mercado após relatos de mortes. Ao longo desses anos, diversos estudos comprovaram a segurança dos ACE, porém com poucos estudos relacionados ao SonoVue®. Objetivos Avaliar a segurança do SonoVue® durante o ecocardiograma sob estresse farmacológico (EEF) por meio da análise da incidência de reações alérgicas e da comparação entre os grupos quanto ao surgimento de arritmia, efeitos colaterais menores e eventos adversos. Métodos Estudo observacional, prospectivo, no qual 2.346 pacientes foram submetidos ao EEF e divididos em dois grupos: grupo 1 com ACE (n=1.099) e grupo 2 sem ACE (n=1.247). Os pacientes foram avaliados durante o EEF – 24 horas e 30 dias. Foi definido p significativo quando <0,05. Resultados O grupo 1 apresentou efeitos colaterais mais leves, como cefaleia (5/0,5% vs. 19/1,5%, p=0,012) e hipertensão reativa (3/0,3% vs . 19/1,5%, p=0,002), menos arritmias como extrassístoles ventriculares (180/16,4% vs . 247/19,8%, p=0,032) e taquicardia paroxística supraventricular (2/0,2% vs . 15/1,2%, p=0,003), assim como nenhum evento adverso como infarto agudo do miocárdio (IAM) e óbito. No grupo 2, um paciente apresentou IAM <24h (1/01%) e dois óbitos <30 dias (2/0,1%). Urticária relacionada ao SonoVue® foi observada em 3 (0,3%) pacientes sem reação anafilática. Conclusão SonoVue® demonstrou segurança durante o EEF, não sendo observados morte, IAM ou reação anafilática. Observou-se menor incidência de efeitos colaterais mais leves e arritmias no grupo que utilizou o ACE, assim como baixa incidência de reações alérgicas leves.

Abstract Background In 2007, the United States Food and Drug Administration mandated safety reviews of commercially available echocardiographic contrast agents (ECA), following reports of death. During the past years, different studies have proven the safety of ECA, but there have been few studies on SonoVue®. Objectives To evaluate the safety of SonoVue® during pharmacological stress echocardiography (PSE), by analyzing the incidence of allergic reactions and comparing groups regarding the appearance of arrhythmia, minor side effects and adverse events. Methods In this observational, prospective study, 2346 patients underwent PSE, and they were divided into the following 2 groups: group 1 with ECA (n = 1099) and group 2 without ECA (n = 1247). Patients were evaluated during PSE, at 24 hours, and at 30 days. Statistical significance was defined as p < 0.05. Results Group 1 had fewer minor side effects, such as headache (5/0.5% versus 19/1.5%, p = 0.012) and less reactive hypertension (3/0.3% versus 19/1.5%, p = 0.002); fewer arrhythmias, such as ventricular extrasystoles (180/16.4% versus 247/19.8%, p = 0.032) and paroxysmal supraventricular tachycardia (2/0.2% versus 15/1.2%, p = 0.003); and no adverse events, such as acute myocardial infarction (AMI) or death. In group 2, 1 patient had AMI in < 24 hours (1/01%), and there were 2 deaths in < 30 days (2/0.1%). SonoVue®-related urticaria was seen in 3 (0.3%) patients, without anaphylactic reaction. Conclusion SonoVue® demonstrated safety during PSE. No cases of death, AMI, or anaphylactic reaction were observed. There was a lower incidence of minor side effects and arrhythmias in the group that received ECA, as well as a low incidence of mild allergic reactions.

https://doi.org/10.36660/abc.20200475 2 downloads

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Glossário e ajuda para busca

Você pode enriquecer sua busca de uma forma muito simples. Use os índices de pesquisa combinados com os conectores (AND ou OR) e especifique cada vez mais sua busca.

Por exemplo, se você deseja buscar artigos sobre
casos de dengue no Brasil em 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

Veja abaixo a lista completa de índices de pesquisa que podem ser usados:

Cód. do Índice	Elemento
ti	título do artigo
au	autor
kw	palavras-chave do artigo
subject	assunto (palavras do título, resumo e palavras-chave)
ab	resumo
ta	título abreviado da revista (ex. Cad. Saúde Pública)
journal_title	título completo da revista (ex. Cadernos de Saúde Pública)
la	código do idioma da publicação (ex. pt - Português, es - Espanhol)
type	tipo do documento
pid	identificador da publicação
publication_year	ano de publicação do artigo
sponsor	financiador
aff_country	código do país de afiliação do autor
aff_institution	instituição de afiliação do autor
volume	volume do artigo
issue	número do artigo
elocation	elocation
doi	número DOI
issn	ISSN da revista
in	código da coleção SciELO (ex. scl - Brasil, col - Colômbia)
use_license	código da licença de uso do artigo

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Email: scielo@scielo.org

Todo o conteúdo de www.scielo.org, exceto onde está identificado, está licenciado sob uma Licença Creative Commons.
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