Pesquisa | SciELO

Penicillium meliponae, a recently described and rare species, was isolated as an endophytic fungus from the Amazonian plant Duguetia sthelechantha, and has been proven to be a pigment producer. Considering the high productivity of this species and the lack of data on its chemical composition, the present study aimed to characterize the chemical profile of P. meliponae and evaluate the influence of agitation and the use of different culture media. For this purpose, liquid chromatography coupled with mass spectrometry (LC-MS/MS) and molecular networking were used, allowing the identification of 17 azaphilone molecules with sclerotiorin-like skeletons, becoming the first chemical report of this species. In addition, the different production patterns in the tested culture media were indicative that this species is sensitive to changes in the composition of the carbon source and to the presence of agitation. Furthermore, this work contributes to the fragmentation mechanisms of the different possible structural arrangements for azaphilones of the sclerotiorin type and serves as a repository of information on the gas-phase behavior of this type of metabolite in mass spectrometry experiments and will assist future studies aimed at the discovery of azaphilones.

https://doi.org/10.21577/0103-5053.20230027

Thulium fiber laser in cystine calculi
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Gismondi, João Pedro Machado

; Bento, Afonso da Silva Alves

; Mazzucchi, Eduardo

; Nahas, William Carlos

International braz j urol

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Ago 2023, Volume 49 Nº 4 Páginas 519 - 520

Resumo: En | Texto: En | PDF: En

ABSTRACT Introduction: Thulium Fiber Laser (TFL) is the most modern technology to treat nephrolithiasis and ureterolithiasis in endourology. Although there are a lot of new studies coming up, we still don't have data on how this laser works in some rare diseases. Cystinuria is the most common genetic nephrolithiasis disorder (1), known for its recurrent lithiasis (2). Our main goal in this video is to show a successful case of cystine calculi treated with Thulium Fiber Laser (Laser Fiber Dust/Quanta System™). Cystinuria is the most common genetic nephrolithiasis disorder (1), known for its recurrent lithiasis (2). Materials and Methods: A 25 years-old male, cystinuric, presented with a CT scan, showing a 10mm stone on the right side and two calculi 6 and 7 mm on the left side, all located in the lower calyx. Bilateral flexible ureteroscopy was done using a reusable digital flexible ureteroscope. Starting on the left side, we repositioned the stone from the lower to the upper calyx, using a tipless front opening basket. Lithotripsy was performed using TFL. Settings were 100 Hz (frequency) and 100 mJ (energy) for dusting. Popcorn technique was also used, setting the laser at 100Hz and 200 mJ, obtaining good dusting. On the right side, lithotripsy was performed in the inferior calyx, also resulting in “snowstorm”. Procedure time was 120 minutes. Results: The postoperative was uneventful. Follow up CT showed a 3 mm residual fragment in the right kidney. Conclusion: This video demonstrates the treatment of bilateral cystine calculi with Thulium Fiber Laser. Reasonable procedure time and excellent dusting results are encouraging, pointing towards great improvements in endourology.

https://doi.org/10.1590/s1677-5538.ibju.2023.0024

EVALUATION OF THE EFFECTS OF PRICE, EXCHANGE, AND VOLUME ON THE GROWTH OF REVENUES FROM BRAZILIAN EXPORTS OF WOOD PRODUCTS
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Sawinski Junior, Jose

; Silva, João Carlos Garzel Leodoro da

; Hoeflich, Vitor Afonso

; Maciel, Ademilson de Souza

Revista Árvore

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2023, Volume 47 elocation e4703

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Brazil has advanced in export volume but has not been able to increase prices over the last decade for wood products. This work seeks to contribute to the understanding of this conflicting scenario, evaluating the growth in the revenue of Brazilian exports of these products during two periods: 2011-2015 and 2016-2020, as well as decomposing its effects in price, exchange rate, and volume. The method applied was the shift-share, widely used to identify determinants of sectoral and regional economic growth, being a precursor to the approach in the analysis of forest sector exports. Historical series for 5 (five) categories of wood products were analyzed, with export data from the Ministry of Economy. The historical series of nominal exchange rates from the Institute of Applied Economic Research (IPEA) was used. The real effective exchange rate (RER) followed the methodological note of the IPEA. All product categories analyzed had positive effects in terms of volume, for both periods, with a greater proportion in the second being driven by the exchange rate, although with a loss in real price, failing to offset inflation. The only exception was wood manufacturers, a product with higher added value, which presented gains in volume, exchange rates, and price. The volume effect was the most relevant, followed by the exchange rate as a result of the appreciation of the dollar against the real against the exchange rate and control of inflation in terms of the divergent effects on the national and international scenario. The price presented negative variations in export revenue, with a decline over the period. In addition to the added value of exported products, world stocks and levels of consumption may have contributed negatively to this scenario, affecting all categories of exported products, except for manufactured wood products, the only category that did not reflect such justifications.

RESUMO O Brasil avançou em volume de exportação, mas não conseguiu aumentar preços ao longo da última década para os produtos de madeira. Este trabalho busca contribuir com o entendimento deste cenário destoante, avaliando o crescimento na receita das exportações brasileiras desses produtos durante dois períodos: 2011-2015 e 2016-2020, bem como, decompondo seus efeitos em preço, câmbio e volume. O método aplicado foi o shift-share, amplamente utilizado para identificar determinantes do crescimento econômico setorial e regional, sendo precursora a abordagem em análise de exportações do setor florestal. Foram analisadas séries históricas para 5 (cinco) categorias de produtos de madeira, com dados de exportação do Ministério da Economia. Utilizou-se a série histórica de taxa de câmbio nominal do Instituto de Pesquisa Econômica Aplicada (IPEA). A taxa de câmbio efetiva real (TCR) seguiu a nota metodológica do IPEA. Todas as categorias de produtos analisadas apresentaram efeitos positivos em volume, para ambos os períodos, com maior proporção no segundo, sendo impulsionado pelo câmbio muito embora com perda em preço real, não conseguindo compensar a inflação. A única exceção foi com manufaturas de madeira, produto de maior valor agregado, que apresentou ganhos em volume, câmbio e preço. O efeito volume foi o mais relevante, em seguida o câmbio como reflexo da valorização do dólar frente ao real em face da taxa de câmbio e controle de inflação em termos dos efeitos divergentes no cenário nacional e internacional. O preço apresentou variações negativas na receita de exportação com queda ao longo do período. Além de valor agregado dos produtos exportados, estoques mundiais e níveis de consumo podem ter contribuído negativamente com este cenário, afetando todas as categorias de produtos exportados, exceto produtos manufaturados de madeira, única categoria que não refletiu tais justificativas.

https://doi.org/10.1590/1806-908820230000003

Characterization of Artificial Stone Developed with the Incorporation of Granite and Mirror Wastes in an Epoxy Matrix
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Silva, Thaís Leal da Cruz

; Carvalho, Elaine Aparecida Santos

; Barreto, Gabriela Nunes Sales

; Agrizzi, Carlos Paulino

; Azevedo, Afonso R. G. de

; Vieira, Carlos Maurício Fontes

Materials Research

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2023, Volume 26 Supl. 1 elocation e20220561

Resumo: En | Texto: En | PDF: En

The objective of this research was to produce artificial stone plates based on granite and mirror wastes and epoxy matrix, by vibration, compression, and vacuum and to characterize them. Plates were manufactured with 15%wt epoxy resin and 85% of aggregates in the proportion of 1/3 of granite waste from Ocre Itabira gray granite and 2/3 of mirror waste. The apparent density, water absorption, and apparent porosity values were 2.22 g/cm3, 0.11%, and 0.25%, respectively, the flexural strength was 34.36 MPa, abrasive wear after a 1000m track was 2.28mm and the breaking height in the impact resistance test was 0.45m. In addition, the stone was resistant to several staining agents. Therefore, the technical viability of the material developed was verified, with results compatible with studies already carried out in the area, making it possible to apply it as coatings and countertops in civil construction.

https://doi.org/10.1590/1980-5373-mr-2022-0561

Proteomic characterization and biological activities of the mucus produced by the zoanthid Palythoa caribaeorum (Duchassaing & Michelotti, 1860)
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SILVA, MARLLYN M.

; CAMPOS, THIERS A.

; CAVALCANTI, ISABELLA M.F.

; OLIVEIRA, IDJANE S.

; PÉREZ, CARLOS DANIEL

; SILVA, ROBERTO AFONSO DA

; WANDERLEY, MARCELA S.O.

; SANTOS, NOEMIA P.S.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Nº 4 elocation e20200325

Resumo: En | Texto: En | PDF: En

Abstract Mucus, produced by Palythoa caribaeorum has been popularly reported due to healing, anti-inflammatory, and analgesic effects. However, biochemical and pharmacological properties of this mucus remains unexplored. Therefore, the present study aimed to study its proteome profile by 2DE electrophoresis and MALDI-TOF. Furthermore, it was evaluated the cytotoxic, antibacterial, and antioxidant activities of the mucus and from its protein extract (PE). Proteomics study identified14 proteins including proteins involved in the process of tissue regeneration and death of tumor cells. The PE exhibited cell viability below 50% in the MCF-7 and S-180 strains. It showed IC50 of 6.9 μg/mL for the J774 lineage, and also, favored the cellular growth of fibroblasts. Furthermore, PE revealed activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Staphylococcus epidermidis (MIC of 250 μg/mL). These findings revealed the mucus produced by Palythoa caribaeorum with biological activities, offering alternative therapies for the treatment of cancer and as a potential antibacterial agent.

https://doi.org/10.1590/0001-3765202320200325

The Sistine Chapel and clothesline signs: a tale of two arteries signs
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Coutinho, Léo

; Marcon, João Matheus Tussolini

; Oliveira, Ellen Riedi

; Murakami, Camila Emi Fujiwara

; Silva, Jessica Castro

; Muzzio, Juliano André

; Zetola, Viviane Hiroki Flumignan

; Lange, Marcos Christiano

; Engelhorn, Carlos Alberto

; Souza, Paulo Cesar Evaristo

; Teive, Hélio Afonso Ghizoni

Arquivos de Neuro-Psiquiatria

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Nov 2022, Volume 80 Nº 11 Páginas 1182 - 1183

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1055/s-0042-1758395

New insights into the anti-erosive property of a sugarcane-derived cystatin: different vehicle of application and potential mechanism of action
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GIRONDA, Carlos Condarco

; PELÁ, Vinícius Taioqui

; HENRIQUE-SILVA, Flávio

; DELBEM, Alberto Carlos Botazzo

; PESSAN, Juliano Pelim

; BUZALAF, Marília Afonso Rabelo

Journal of Applied Oral Science

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2022, Volume 30 elocation e20210698

Resumo: En | Texto: En | PDF: En

Abstract A new sugarcane-derived cystatin (CaneCPI-5) showed anti-erosive properties when included in solutions and strong binding force to enamel, but the performance of this protein when added to gel formulations and its effect on surface free energy (SFE) requires further studies. Objective 1) to evaluate the protective effect of gels containing different concentrations of CaneCPI-5 against initial enamel erosion (Experiment 1); and 2) to analyze the SFE (γS) after treating the enamel surface with CaneCPI-5 solution (Experiment 2). Methodology In Experiment 1, 75 bovine enamel specimens were divided into five groups according to the gel treatments: placebo (negative control); 0.27%mucin+0.5%casein (positive control); 0.1 mg/mL CaneCPI-5; 1.0 mg/mL CaneCPI-5; or 2.0 mg/mL CaneCPI-5. Specimens were treated with the gels for 1 min, the AP was formed (human saliva) for 2 h and the specimens were incubated in 0.65% citric acid (pH=3.4) for 1 min. The percentage of surface hardness change (%SHC) was estimated. In Experiment 2, measurements were performed by an automatic goniometer using three probing liquids: diiodomethane, water and ethylene glycol. Specimens (n=10/group) remained untreated (control) or were treated with solution containing 0.1 mg/mL CaneCPI-5, air-dried for 45 min, and 0.5 µL of each liquid was dispensed on the surface to measure contact angles. Results Gels containing 0.1 and 1.0 mg/mL CaneCPI-5 significantly reduced %SHC compared to the other treatments (p<0.05). Treated enamel showed significantly lower γS than control, without changes in the apolar component (γSLW), but the polar component (γSAB=Lewis acid-base) became more negative (p<0.01). Moreover, CaneCPI-5 treatment showed higher γS - (electron-donor) values compared to control (p<0.01). Conclusions Gels containing 0.1 mg/mL or 1.0 mg/mL CaneCPI-5 protected enamel against initial dental erosion. CaneCPI-5 increased the number of electron donor sites on the enamel surface, which may affect AP formation and could be a potential mechanism of action to protect from erosion.

https://doi.org/10.1590/1678-7757-2021-0698

Chronic Lymphocytic Leukemia (CLL): evaluation of AKT protein kinase and microRNA gene expression related to disease pathogenesis
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Gomes, Lorena Caixeta

; Resende, Rodrigo Ribeiro

; Parreira, Ricardo Cambraia

; Ferreira, Cláudia Natália

; Reis, Edna Afonso

; Duarte, Rita Carolina Figueiredo

; Alves, Luan Carlos Vieira

; Araújo, Sergio Schusterschitz da Silva

; Carvalho, Maria das Graças

; Sabino, Adriano de Paula

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e19946

Resumo: En | Texto: En | PDF: En

Abstract The present study evaluated 56 patients diagnosed with Chronic Lymphocytic Leukemia (CLL) and a control group of 44 clinically healthy subjects with no previous history of leukemia. Genetic expressions of AKT and microRNAs were evaluated by quantitative PCR (qPCR). A significant increase in AKT gene expression in patients when compared to controls was observed (p = 0.017). When the patients were stratified according to Binet subgroups, a significant difference was observed between the subgroups, with this protein kinase appearing more expressed in the B+C subgroup (p = 0.013). Regarding miRNA expression, miR-let-7b and miR-26a were reduced in CLL patients, when compared to controls. However, no significant differences were observed in these microRNA expressions between the Binet subgroups (A versus B+C). By contrast, miR-21 to miR-27a oncogenes showed no expression difference between CLL patients and controls. AKT protein kinase is involved in the signaling cascade that occurs with BCR receptor activation, leading to increased lymphocyte survival and protection against the induction of cell death in CLL. Thus, increased AKT protein kinase expression and the reduction of miR-let-7b and miR-26a, both tumor suppressors, may explain increased lymphocyte survival in CLL patients and may be promising markers for the prognostic evaluation of this disease.

https://doi.org/10.1590/s2175-97902022e19946

Effect of handpiece light and material used in pulp chamber on dentin removal during root canal retreatment
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Gomes, Marcio Alex Barros

; Leão, Igor Firmino Pereira

; Oliveira, Laís Rani Sales

; Pereira, Renata Afonso da Silva

; Soares, Priscilla Barbosa Ferreira

; Soares, Carlos José

Brazilian Dental Journal

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Set 2021, Volume 32 Nº 5 Páginas 87 - 95

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este estudo avaliou os efeitos do cimento de ionômero de vidro (GIC) e da resina composta fluida bulk fill (BFRC) usados como preenchimento da câmara pulpar; e o tipo de iluminação das turbinas de alta rotação na remoção dentinária após cavidades de acesso para retratamento endodôntico em dentes molares. Vinte molares superiores foram tratados endodonticamente. Dez dentes foram restaurados usando BFRC (Opus Bulk Fill Flow APS, FGM) para preencher a câmara pulpar e dentina coronária; e resina composta convencional (Opallis, FGM) para restaurar a camada de esmalte. Os outros dentes foram restaurados usando GIC (Maxion R, FGM) para preencher a câmara pulpar e resina composta (Opallis, FGM). As amostras foram divididas em dois grupos e os canais radiculares foram novamente acessados com turbina de alta-rotação com iluminação branca ou ultravioleta. Os dentes foram escaneados usando micro-CT antes e após o novo acesso ao canal radicular. O volume de dentina removida foi calculado e os dados foram analisados por ANOVA bidirecional e teste de Tukey (α=0,05). As regiões na coroa e na câmara pulpar que apresentaram dentina removida no acesso dos canais foram descritas por meio de distribuição por frequência. A reabertura do canal radicular com GIC resultou em menos paredes afetadas da câmara pulpar e menor volume de dentina removida no assoalho. Nenhum efeito foi observado nas paredes de dentina coronária considerando aos protocolos de preenchimento. A turbina de alta rotação com iluminação branca reduziu a remoção de dentina da câmara pulpar, independentemente do protocolo de restauração utilizado. O uso de turbina de alta rotação com iluminação branca e GIC para preencher a câmara pulpar reduziram a remoção de dentina do assoalho e afetaram menos paredes dentinárias.

Abstract This study evaluated the effect of the use of glass ionomer cement (GIC) and flowable bulk-fill resin composite (BFRC) for filling pulp chambers and the type of high-speed handpiece light used on dentin removal during access preparation for endodontic retreatment in molar teeth. Twenty maxillary molars were treated endodontically. BFRC (Opus Bulk Fill Flow APS, FGM) was used to fill the pulp chamber and replace coronal dentin (n = 10). In the remaining teeth, the pulp chamber was filled with GIC (Maxion R, FGM). Conventional resin composite (Opallis, FGM) was used to restore the enamel layer in all teeth. The samples in each group were divided into two subgroups, and the root canals were reaccessed using a handpiece with white or ultraviolet light. The teeth were scanned using micro-CT before and after root canal reaccess. The dentin volume removed was calculated and analyzed using 2-way analysis of variance and Tukey’s test (α = 0.05). The crown and pulp chamber locations with dentin removal are described using frequency distribution. During the access, fewer pulp chamber walls were affected and a lower volume of dentin was removed from the pulpal floor in the group restored with GIC than in the group restored with BFRC. No effect was observed on the coronal dentin walls with respect to the filling protocols and type of light used. For dentin removal from the pulp chamber, handpieces with white light performed better than those with ultraviolet light, irrespective of the filling protocol used. The use of GIC to fill the pulp chamber and use of white handpiece light reduced dentin removal from the pulpal floor and resulted in fewer affected dentin walls.

https://doi.org/10.1590/0103-6440202103926 1 downloads

10.

Selective Hemorrhoidal Dearterialization with High Mucopexy in the Surgical Treatment of Hemorrhoidal Disease
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Rotta, Carlos Mateus

; Drago, Stephanie

; Sousa Jr, Afonso Henrique da Silva e

; Martinez, Carlos Augusto Real

; Bernardino, Marjorie Cristina da Cruz

Journal of Coloproctology (Rio de Janeiro)

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Jul 2021, Volume 41 Nº 3 Páginas 234 - 241

Resumo: En | Texto: En | PDF: En

Abstract The doppler-guided transanal hemorrhoidal dearterialization technique associated with mucopexy is a noninvasive surgical option used to treat hemorrhoidal disease (HD). Objective To compare and analyze the results using a variation of the doppler-guided transanal hemorrhoidal dearterialization technique with the technique of selective hemorrhoidal dearterialization with high mucopexy in the treatment of HD. Method A total of 292 patients who underwent surgical treatment for grade II, III and IV HD from March 2012 to December 2017 were studied. From this total, 110 (37.6%) patients underwent a conventional doppler-guided transanal hemorrhoidal dearterialization with mucopexy (CD), and 182 (62.3%) underwent selective hemorrhoidal dearterialization with highmucopexy (SHeLF). In the group of patients undergoing CD, 4 patients (3.64%) had grade II HD, 82 (74.55%) grade III, and 24 (21.82%) grade IV. In the group submitted to SHeLF, 18 (9.89%) patients had grade II HD, 86 (47.25%) had grade III, and 65 (35.71%) had grade IV. The same surgeon operated all patients under spinal anesthesia. In patients undergoing CD, six arterial branches have been dearterialized, while in patients undergoing SHeLF, the hemorrhoidary nipples submitted to a dearterialization were selected (from 1 to 5) by intraoperative evaluation followed by high rectal mucopexy. In the postoperative period, the following parameters were evaluated: pain, tenesmus, bleeding, and recurrence. Moderate results to severe pain was a postoperative complaint reported by 13 (11.82%) patients undergoing CD, and by 19 (10.44%) undergoing SHeLF. Intense tenesmus was reported by 26 (23.64%) patients undergoing CD and by 7 (3.85%) undergoing SHeLF. Three patients (2.73%) undergoing CD and 1 (0.55%) undergoing SHeLF evolved with postoperative bleeding. One patient (0.55%) in the group undergoing CD required surgical review of hemostasis. Six patients (5.45%) who underwent CD and 8 (4.39%) who underwent SHeLF were reoperated due to disease recurrence. Conclusion Comparing statistics, patients undergoing the SHeLF technique have less postoperative pain, tenesmus and postoperative bleeding when compared with CD.

https://doi.org/10.1055/s-0041-1735544 13 downloads

11.

Application of Spatial Modeling of Biophysical Variables in an Urbanized Area in the Amazon: The Case of the Metropolitan Area of Belém-Pará
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Silva, Madson Tavares

; Margalho, Eduardo da Silva

; Serrão, Edivaldo Afonso de Oliveira

; Souza, Amanda Cartaxo de

; Soares, Caroline de Sá

; Santos, Carlos Antonio Costa dos

; Silva, Bernardo Barbosa da

Revista Brasileira de Meteorologia

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Jun 2021, Volume 36 Nº 2 Páginas 271 - 283

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O tipo e uso cobertura do solo desempenham papel decisivo para a temperatura da superfície continental (LST). Como as cidades são compostas por coberturas variadas, incluindo vegetação, áreas construídas, prédios, estradas e áreas desprovidas de vegetação, compreender os padrões da LST no complexo espaço urbano se faz cada vez mais importante. O presente estudo investigou a relação da LST com o albedo, NDVI, NDWI, NDBI e NDBaI no período de 1994 e 2017. Foram utilizadas imagens dos sensores Thematic Mapper (TM) e Thermal Infrared Sensor (TIRS) a bordo dos satélites Landsat 5 e 8, respectivamente. As imagens foram processadas, reamostradas (resolução espacial de 120 m) no ambiente do software QGIS 3.0 e, por fim, foram extraídos centroides com um total de 1252 pontos. O modelo de regressão clássica (RC) foi aplicado às variáveis seguidas por modelos espaciais autoregressivos e de erro espacial (MEAR e MEE) e os resultados foram comparados a partir de índices de acurácia. Os resultados mostram que o maior coeficiente de correlação existe foi verificado entre albedo e NDBaI (r = 0,88). A relação entre o albedo e a LST, com r = 0,7, também é positiva e significativa ao nível de (р < 0,05). A partir do índice I de Moran Global verificou-se a dependência espacial e não estacionariedade da LST (I = 0,44). O modelo MEE apresentou as melhores métricas de acurácia (AIC = 3307,15 e R2 = 0,65) explicando consideravelmente mais variações na relação dos fatores explicativos e da LST para a região metropolitana de Belém, quando comparados aos modelos convencionais de RC.

Abstract The type of land use and land cover plays a decisive role in land surface temperature (LST). As cities are composed of varied covers, including vegetation, built-up areas, buildings, roads and areas without vegetation, understanding LST patterns in complex urban spaces is becoming increasingly important. The present study investigated the relationship between LST and albedo, NDVI, NDWI, NDBI and NDBaI in the period between 1994 and 2017. Images from Thematic Mapper (TM) and Thermal Infrared Sensor (TIRS) onboard the Landsat 5 and 8 satellites, respectively, were used in the study. The images were processed, resampled (spatial resolution of 120 m) in the environment of the QGIS 3.0 software and, finally, centroids were extracted resulting in a total of 1252 points. A classical regression (CR) model was applied to the variables, followed by spatial autoregressive (SARM) and spatial error (SEM) models, and the results were compared using accuracy indices. The results showed that the highest correlation coefficient was found between albedo and NDBaI (r = 0.88). The relationship between albedo and LST (r = 0.7) was also positive and significant at р < 0.05. The global Moran's I index showed spatial dependence and non-stationarity of the LST (I = 0.44). The SEM presented the best accuracy metrics (AIC = 3307.15 and R2 = 0.65) for the metropolitan region of Belém, explaining considerably more variations in the relationship between explanatory factors and LST when compared to conventional CR models.

https://doi.org/10.1590/0102-77863620063 266 downloads

12.

Cannabinoids in Neurology - Position paper from Scientific Departments from Brazilian Academy of Neurology
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BRUCKI, Sonia Maria Dozzi

; ADONI, Tarso

; ALMEIDA, Carlos Mauricio Oliveira

; ANDRADE, Daniel Ciampi de

; ANGHINAH, Renato

; BARBOSA, Luciana Mendonça

; BAZAN, Rodrigo

; CARVALHO, Alzira Alves de Siqueira

; CARVALHO, William

; CHRISTO, Paulo Pereira

; COLETTA, Marcus Della

; CONFORTO, Adriana Bastos

; CORREA-NETO, Ylmar

; ENGELHARDT, Eliasz

; FRANÇA JUNIOR, Marcondes Cavalcante

; FRANCO, Clelia

; VON GLEHN, Felipe

; GOMES, Helio Rodrigues

; HOULY, Caroline Gomes de Barros

; KAUP, Alexandre Ottoni

; KOWACS, Fernando

; KANASHIRO, Aline

; LOPES, Victor Gonçalves

; MAIA, Débora

; MANREZA, Maria

; MARTINEZ, Alberto Rolim Muro

; MARTINEZ, Sandra Cristina Gonçalves

; NADER, Saulo Nardy

; NEVES, Luciana de Oliveira

; OKAMOTO, Ivan Hideyo

; OLIVEIRA, Rogério Adas Ayres de

; PEIXOTO, Fabiano de Melo

; PEREIRA, Cristiana Borges

; SABA, Roberta Arb

; SAMPAIO, Leticia Pereira de Brito

; SCHILLING, Lucas Porcello

; SILVA, Marcus Tulius Teixeira

; SILVA, Emanuelle Roberta

; SMID, Jerusa

; SOARES, Cristiane Nascimento

; SOBREIRA-NETO, Manoel

; SOUSA, Nise Alessandra de Carvalho

; SOUZA, Leonardo Cruz de

; TEIVE, Hélio Afonso Ghizoni

; TERRA, Vera Cristina

; VALE, Matheus

; VIEIRA, Vitor Mendes Grise

; ZANOTELI, Edmar

; PRADO, Gilmar

Arquivos de Neuro-Psiquiatria

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Abr 2021, Volume 79 Nº 4 Páginas 354 - 369

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Os canabinoides compreendem os endocanabinoides, fitocanabinoides e os canabinoides sintéticos e desempenham ações no sistema nervoso central e periférico. Uma quantidade enorme de publicações tem sido lançada nos últimos anos, embora a cannabis seja conhecida por milênios. Os Departamentos Científicos da Academia Brasileira de Neurologia descreveram as evidências do uso médico em suas áreas. A literatura está em constantes mudanças e possíveis novas evidências podem surgir nos próximos dias ou meses. A prescrição dessas substâncias deve ser discutida com os pacientes e suas famílias, com conhecimento sobre eventos adversos e sua eficácia.

ABSTRACT Cannabinoids comprehend endocannabinoids, phytocannabinoids, and synthetic cannabinoids, with actions both in the central and peripherical nervous systems. A considerable amount of publications have been made in recent years, although cannabis has been known for over a thousand years. Scientific Departments from the Brazilian Academy of Neurology described evidence for medical use in their areas. Literature is constantly changing, and possible new evidence can emerge in the next days or months. Prescription of these substances must be discussed with patients and their families, with knowledge about adverse events and their efficacy.

https://doi.org/10.1590/0004-282x-anp-2020-0432 1049 downloads

13.

Variabilidade Temporal da Cobertura das Terras nos Estados da Paraíba e Rio Grande do Norte
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Oliveria, Verônica Gabriella de

; Silva, Madson Tavares

; Santos, Carlos Antonio Costa dos

; Serrão, Edivaldo Afonso de Oliveira

; Silva, Bruce Kelly da Nobrega

; Santos, Marcos Ronielly da Silva

; Corrêa, Irene Cristina Pereira

Revista Brasileira de Meteorologia

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Mar 2021, Volume 36 Nº 1 Páginas 125 - 136

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo desse estudo foi avaliar a variabilidade espaço-temporal do NDVI, da temperatura da superfície terrestre (TST) e da precipitação pluvial (PCP) em regiões de Caatinga degradada (CD) e em recuperação (CR) no Estado da Paraíba, e preservada (CP) no Estado do Rio Grande do Norte. Foram aplicadas técnicas de sensoriamento remoto (SR) do sensor MODIS/Terra com utilização de testes não-paramétricos e tendência. Nas áreas CD e CR o período chuvoso é caracterizado entre o outono-inverno representando mais de 70% do total anual. A CP apresenta dois padrões significativos da PCP, o primeiro associado ao verão, em que os acumulados representam 33,4% do total anual, e o segundo no outono representando 52,8%. Os maiores valores médios mensais de NDVI estão presente na CR. Na CD, foram verificados os maiores valores da TST. As maiores correlações negativas entre TST e PCP e entre TST e NDVI foram encontradas na CR (-0,73) e CP (-0,86), respectivamente. Foi obtida relação positiva entre NDVI e PCP em todos os ambientes, com destaque para a CP (0,84). Os resultados encontrados, evidenciam que os produtos de SR do sensor MODIS são importantes para o entendimento dos impactos antrópicos e climáticos na dinâmica da vegetação de Caatinga.

Abstract The objective of this study was to evaluate the spatial-temporal variation of NDVI, the temperature of the earth's surface (TST) and rainfall (PCP) in the degraded Caatinga (DC) and recovery (CR) regions in the State of Paraíba, and preserved (CP) in the State of Rio Grande do Norte. MODIS /Terra sensor remote sensing (SR) techniques were applied using non-parametric and trend tests. In the CD and CR areas, the rainy season is included in autumn-winter, representing more than 70% of the annual total. The CP presents two patterns of use of the PCP, the first associated in the summer, and the accumulated ones represent 33,4% of the annual total, and the second number of autumn represented 52,8%. The highest average monthly NDVI values are present in the CR. The CD showed the highest TST values. The greatest negative correlations between TST and PCP and between TST and NDVI were found in CR (-0,73) and CP (-0,86), respectively. A positive relationship between NDVI and PCP was selected in all environments, with an emphasis on a PC (0,84). The results found, evidence that SR products from the MODIS sensor are important for understanding anthropogenic and climatic impacts on Caatinga vegetation.

https://doi.org/10.1590/0102-77863610011 348 downloads

14.

Roberto Melaragno's scientific contributions to Brazilian Neurology
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Limongi, João Carlos Papaterra

; Lima, Plinio Marcos Garcia

; Silva, Sonia Maria César de Azevedo

; Ferreira, Matheus Gomes

; Barbosa, Egberto Reis

; Teive, Hélio Afonso Ghizoni

Arquivos de Neuro-Psiquiatria

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Fev 2021, Volume 79 Nº 2 Páginas 175 - 177

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Roberto Melaragno Filho, professor livre-docente em neurologia pela Faculdade de Medicina da Universidade de São Paulo, e chefe do serviço de neurologia do Hospital do Servidor Público Estadual Francisco Morato de Oliveira (HSPE-FMO), teve uma carreira científica de grande relevo, sendo reconhecido nacionalmente como uma das referências em neurologia no século XX, além de ter tido uma notável carreira internacional.

ABSTRACT Roberto Melaragno Filho, an associate professor of neurology at the School of Medicine of Universidade de São Paulo and head of the neurology service at Hospital do Servidor Público Estadual Francisco Morato Oliveira (HSPE-FMO), had a significant scientific career. He is recognized as a reference in the 20th century Brazilian neurology in addition to having a notable international career.

https://doi.org/10.1590/0004-282x-anp-2020-0293 420 downloads

15.

Prevalence of virological and serological markers of SARS-CoV-2 infection in the population of Ribeirão Preto, Southeast Brazil: an epidemiological survey
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Martinez, Edson Zangiacomi

; Passos, Afonso Dinis Costa

; Fabbro, Amaury Lelis Dal

; Silva, Anderson Soares da

; Escarso, Andreia Cássia

; Pazin-Filho, Antônio

; Fonseca, Benedito Antônio Lopes da

; Maciel, Benedito Carlos

; Araújo, Daniel Cardoso de Almeida e

; Clé, Diego Villa

; Gaspar, Gilberto Gambero

; Santos, Jair Lício Ferreira dos

; Ferreira, Janise Braga Barros

; Souza, João Paulo

; Mello, Luane Marques de

; Santos, Luciane Loures dos

; Passos, Luzia Márcia Romanholi

; Siconelli, Márcio Junio Lima

; Cavalli, Ricardo de Carvalho

; Santana, Rodrigo de Carvalho

; Calado, Rodrigo do Tocantins

; Scarpelini, Sandro

; Bollela, Valdes Roberto

; Floriano, Vitor Gonçalves

; Bellissimo-Rodrigues, Fernando

Revista da Sociedade Brasileira de Medicina Tropical

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2021, Volume 54 elocation e0210-2021

Resumo: En | Texto: En | PDF: En

Abstract INTRODUCTION: This epidemiological household survey aimed to estimate the prevalence of the current and past SARS-CoV-2 infections in Ribeirão Preto, a municipality of southeast Brazil. METHODS: The survey was conducted in two phases using a clustered sampling scheme. The first phase spanned May 1-3 and involved 709 participants. The second phase spanned June 11-14, 2020, and involved 646 participants. RESULTS: During the first phase, RT-PCR performed on nasopharyngeal swabs was positive at 0.14%. The serological tests were positive in 1.27% of the patients during the first phase and 2.79% during the second phase. People living in households with more than five members had a prevalence of 10.83% (95%CI: 1.58-74.27) higher than those living alone or with someone other. Considering the proportion of the positive serological test results with sex and age adjustments, approximately 2.37% (95%CI: 1.32-3.42) of the population had been cumulatively infected by mid-June 2020, which is equivalent to 16,670 people (95%CI: 9,267-24,074). Considering that 68 deaths from the disease in the residents of the city had been confirmed as at the date of the second phase of the survey, the infection fatality rate was estimated to be 0.41% (95%CI: 0.28-0.73). Our results suggest that approximately 88% of the cases of SARS-CoV-2 infection at the time of the survey were not reported to the local epidemiological surveillance service. CONCLUSIONS: The findings of this study provide in-depth knowledge of the COVID-19 pandemic in Brazil and are helpful for the preventive and decision-making policies of public managers.

https://doi.org/10.1590/0037-8682-0210-2021 117 downloads

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