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[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Data de publicação: 2024-04-08

Resumo: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Quality of packaged refrigerated biofortified sweet potato cultivars
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Barbosa, Ewerton da S.

; Costa, Pablo R. da

; Brito, Fred A. L. de

; Assis, Joan C. S. de

; Marcelino, Ariel S. de A. N.

; Santos, Valecia N.

; Silva, Lucio J. V.

; Silveira, Flávio P. da M.

; Barros Júnior, Aurélio P.

; Simões, Adriano do N.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Fev 2024, Volume 28 Nº 2 elocation e275946

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Combining refrigeration with packaging is a commonly used technique for fruits intended for export. Thus, the objective of this study was to adapt the post-harvest management of biofortified sweet potato cultivars, using packaging and refrigeration, focused on reaching distant export markets while maintaining the commercial quality. Sweet potatoes of the cultivars BRS-Amélia and Beauregard were selected after harvesting, washed, and packaged. The experimental design used was completely randomized, in a 4 × 7 factorial arrangement consisted of 4 treatments (cultivar BRS-Amélia with and without packaging; and cultivar Beauregard with and without packaging) and 7 evaluations under storage conditions: at 0, 7, 14 (under refrigeration at approximately 8 °C), 17, 20, 23, and 26 days (under room temperature conditions at approximately 25 °C). Each experimental unit contained 500 g of tubbers. The results showed that the refrigerated storage combined with packaging extended the shelf life of the evaluated sweet potatoes: 17 days for BRS-Amélia and 26 days for the cultivar Beauregard. The BRS-Amélia cultivar maintained higher firmness, soluble solids and carbohydrate contents, chroma, and antioxidant activity (FRAP method), and total phenolic contents, in both raw and cooked tissues. The cultivar Beauregard presented less dehydration and greater stability in vitamin C, total phenolic, total carotenoid, soluble carbohydrate, and starch contents in raw and cooked potatoes. Therefore, the combination of packaging and refrigeration preserved the commercial quality of biofortified sweet potatoes for export markets.

RESUMO Combinar refrigeração com embalagem é uma técnica comumente utilizada para frutas destinadas à exportação. Assim, o objetivo deste estudo foi adequar o manejo pós-colheita de cultivares de batata-doce biofortificadas, utilizando embalagem e refrigeração, com foco em atingir mercados de exportação distantes e mantendo a qualidade comercial. As batatas-doces das cultivares BRS-Amélia e Beauregard foram selecionadas após a colheita, lavadas e embaladas. O delineamento experimental utilizado foi inteiramente casualizado, em arranjo fatorial 4 × 7 composto por 4 tratamentos (cultivar BRS-Amélia com e sem embalagem; e cultivar Beauregard com e sem embalagem) e 7 avaliações nas condições de armazenamento: aos 0, 7, 14 (sob refrigeração a aproximadamente 8 °C), 17, 20, 23 e 26 dias (sob condições de temperatura ambiente a aproximadamente 25 °C). Cada unidade experimental continha 500 g de tubérculos. Os resultados mostraram que o armazenamento refrigerado aliado à embalagem prolongou a vida útil da batata-doce avaliada: 17 dias para BRS-Amélia e 26 dias para a cultivar Beauregard. A cultivar BRS-Amélia manteve maior firmeza, solúveis sólidos e teor de carboidratos, croma e atividade antioxidante (método FRAP) e teor de fenólicos totais, tanto nos tecidos crus quanto cozidos. A cultivar Beauregard apresentou menor desidratação e maior estabilidade nos teores de vitamina C, fenólicos totais, carotenóides totais, carboidratos solúveis e amido em batatas cruas e cozidas. Portanto, a combinação de embalagem e refrigeração preservou a qualidade comercial da batata-doce biofortificada para os mercados de exportação.

https://doi.org/10.1590/1807-1929/agriambi.v28n2e275946

Influence of sealer type on treatment outcome of teeth with apical periodontitis: a systematic review
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Amoroso-Silva, Pablo

; Brasil, Sabrina C.

; Pérez, Alejandro R.

; Tolentino, Elen S.

; Alves, Flávio R. F.

; Siqueira Jr, José F.

; Rôças, Isabela N.

Brazilian Dental Journal

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Out 2023, Volume 34 Nº 5 Páginas 1 - 21

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The purpose of this article was to Evaluate the influence of sealer on the outcome of non-surgical endodontic treatment or retreatment of permanent teeth with apical periodontitis (PROSPERO registration: CRD42020205951). Methodology: A systematic review of original clinical studies was carried out following PRISMA guidelines to answer whether the type of sealer used in endodontic treatment or retreatment influences the repair of apical periodontitis determined by clinical and radiographic parameters. Electronic searches were performed in PubMed, Embase, Web of Science, Scopus, and the Cochrane Library database, until May 2023. Gray literature and a hand search of reference lists were also performed. The risk of bias was assessed using Cochrane RoB2 for randomized trials and the Newcastle-Ottawa Scale (NOS) for prospective and retrospective cohort and case-control studies. Results: Among 1046 studies, a total of 819 were selected by title and abstract, resulting in 23 for full-text review. In total, 11 studies met the inclusion criteria (1467 patients/teeth with apical periodontitis). The quality assessment using RoB2 included five randomized control trials, of which four had medium risk and one had a low risk of bias. According to the NOS scale, five studies were classified as low risk and one study was considered as medium risk of bias. The sealer type and obturation techniques varied, and the mean follow-up time was 3.7 years. Most studies used two-dimensional radiographic criteria to assess the treatment outcome sealers and not cements. Eight studies did not find significant differences when comparing cements. The healing rates ranged from 56.7% to 90%. Conclusions: The results of this review support that the current endodontic sealers do not seem to influence the treatment outcome of permanent teeth with apical periodontitis. Although the studies had medium and low risk of bias, the results should be interpreted with caution. More randomized studies of long-term outcomes comparing filling materials are needed to strengthen this claim and allow for a meta-analysis.

Resumo O objetivo deste artigo foi avaliar a influência do cimento no resultado do tratamento ou retratamento endodôntico não cirúrgico de dentes permanentes com periodontite apical (registro PROSPERO: CRD42020205951). Metodologia: Uma revisão sistemática de estudos clínicos originais foi realizada seguindo as diretrizes PRISMA para responder se o tipo de cimento usado no tratamento ou retratamento endodôntico influencia a reparação da periodontite apical determinada por parâmetros clínicos e radiográficos. Pesquisas eletrônicas foram realizadas no PubMed, Embase, Web of Science, Scopus e no banco de dados Cochrane Library, até maio de 2023. A literatura cinza e uma pesquisa manual das listas de referências também foram realizadas. O risco de viés foi avaliado usando Cochrane RoB2 para os estudos randomizados e Newcastle-Ottawa Scale (NOS) para coorte prospectiva e retrospectiva e estudos de caso-controle. Resultados: Entre 1.046 estudos, um total de 819 foram selecionados por título e resumo, resultando em 23 para revisão de texto completo. No total, 11 estudos preencheram os critérios de inclusão (1.467 pacientes/dentes com periodontite apical). A avaliação de qualidade usando RoB2 incluiu cinco estudos randomizados de controle, dos quais quatro tinham risco médio e um tinha baixo risco de viés. De acordo com a escala NOS, cinco estudos foram classificados com baixo risco e um estudo foi considerado com médio risco de viés. O tipo de cimento e as técnicas de obturação variaram, e o tempo médio de acompanhamento foi de 3,7 anos. A maioria dos estudos utilizou critérios radiográficos bidimensionais para avaliar o resultado do tratamento. Oito estudos não encontraram diferenças significativas ao comparar os cimentos. As taxas de reparação variaram de 56,7% a 90%. Conclusões: Os resultados desta revisão suportam que os cimentos endodônticos atuais não parecem influenciar o resultado do tratamento de dentes permanentes com periodontite apical. Embora os estudos tiveram médio e baixo risco de viés, os resultados devem ser interpretados com cautela. Mais estudos randomizados de resultados de longo prazo comparando materiais de obturação são necessários para fortalecer essa afirmação e permitir uma meta-análise.

https://doi.org/10.1590/0103-6440202305471

Body fat, cardiovascular risk factors and polymorphism in the FTO gene: randomized clinical trial and different physical exercise for adolescents
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Bila, Wendell C.

; Romano, Márcia C.C.

; Santos, Luciana L. dos

; Silva, Valmin R. da

; Capanema, Flavio D.

; Pfrimer, Karina

; Ferriolli, Eduardo

; Alves, Natália M.C.

; Campos, Cezenário G.

; Carlos, Fabiângelo M.

; Santos, Maria E.S.M. dos

; Lamounier, Joel A.

Jornal de Pediatria

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Abr 2023, Volume 99 Nº 2 Páginas 139 - 146

Resumo: En | Texto: En | PDF: En

Abstract Objective: To investigate the effects of different physical exercise programs and polymorphisms of the FTO (fat mass and obesity-associated gene) on body composition and cardiovascular risk factors in adolescents with overweight and obesity. Methods: A randomized, parallel, double-blind clinical trial consisting of the adolescent overweight from the state public network, in a simple representative random sample, who participated in an aerobic exercise or weight training intervention for 10 weeks. Anthropometry, body composition, biochemical markers, sexual maturation, and rs9939609 polymorphism in the FTO gene were assessed. 347 adolescents had their characterization of nutritional status. 72 individuals with overweight and obesity were invited to participate. 39 remained for the start of the program and were randomly allocated to both types of intervention. In the end, 26 subjects participated in the intervention programs, with 12 and 14 in the aerobic and weight training programs, respectively. Results: Heterozygous and homozygous bearers of risk allele A participating in the aerobic program showed improvements in glycemia (p = 0.002) and total cholesterol (p = 0.023) and a reduction in body fat mass (p = 0.041). The weight training program reduced glycemia in patients with the risk allele A (p = 0.027). Cameron’s stage four sexual maturation participants were 2.1 times more likely to improve their body fat (CI = 1.31–3.39). Conclusion: Aerobic exercises produced exclusively a significant decrease in fat mass and total cholesterol in patients with risk allele A. Distinct physical exercise programs may cause diverse changes in risk variables related to the health of adolescents.

https://doi.org/10.1016/j.jped.2022.07.004

Impact of the Health Gym Program on hospital admissions for stroke in the state of Pernambuco, Brazil
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Guarda, Flávio Renato Barros da

; Rodrigues, Bárbara Letícia Silvestre

; Silva, Rafaela Niels da

; Faria, Shirlley Jackllanny Martins de

; Silva, Paloma Beatriz Costa

; Silva Júnior, Redmilson Elias da

; Feitosa, Daíze Kelly da Silva

; Anokye, Nana Kwame

; Coyte, Peter C.

Cadernos de Saúde Pública

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2023, Volume 39 Nº 1 elocation e00012922

Resumo: Pt Es En | Texto: Pt Es En | PDF: Pt | PDF: Es | PDF: En

O estudo teve como objetivo avaliar o impacto do Programa Academia da Saúde (PAS) nas internações hospitalares por acidente vascular cerebral (AVC) no Estado de Pernambuco, Brasil. Esta avaliação de impacto das políticas utilizou uma abordagem quase-experimental que consiste em um estimador de diferença-em-diferenças, ponderado pelo pareamento por escore de propensão para lidar com possíveis fatores de confusão. O estudo foi composto por dados socioeconômicos, demográficos e epidemiológicos de bases de dados oficiais brasileiras entre os anos de 2010 e 2019. O grupo de tratamento foi composto pelos 134 municípios que implantaram o PAS a partir de 2011, e os 51 municípios que não implantaram foram alocados no grupo de comparação. O algoritmo do vizinho mais próximo (N5) foi utilizado para emparelhar os municípios tratados e comparar aos municípios do grupo controle, criando os pesos que foram utilizados para avaliar o efeito médio do tratamento sobre o tratado (ATT) no estimador de diferença-em-diferenças. Houve 2.771 internações por AVC em 2010 (0,51% de todas as internações) e 11.542 (2%) em 2019. Os municípios que implementaram o PAS tiveram 18,37% menos internações em comparação com seus homólogos no grupo de comparação. O impacto do programa na redução das taxas de internação foi maior entre os homens (ATT: -0,1932) e naqueles com idade entre 71 e 80 anos (ATT: -0,1911). Todos os resultados foram estatisticamente significativos em um nível de 5%. O PAS reduziu a hospitalização por AVC em vários grupos populacionais, mas principalmente naqueles em que a prevalência subjacente de AVC é mais alta, reforçando a importância dos investimentos públicos em políticas de promoção da saúde destinadas a estimular mudanças nos estilos de vida.

El objetivo de este trabajo es evaluar el impacto del Programa Academia de la Salud (PAS) en los ingresos hospitalarios por accidente cerebrovascular (ACV) en el estado de Pernambuco, Brasil. Esta evaluación del impacto de la política utilizó un enfoque cuasi-experimental que consiste en un estimador de diferencias en diferencias, ponderado por el emparejamiento de puntuación de propensión para hacer frente a posibles factores de confusión. El estudio incluyó datos socioeconómicos, demográficos y epidemiológicos de bases de datos oficiales brasileñas de 2010 a 2019. El grupo de tratamiento se compuso de los 134 municipios que implementaron el PAS a partir de 2011 y los 51 municipios que no lo hicieron se asignaron al grupo de comparación. Se utilizó el algoritmo del vecino más próximo (N5) para emparejar los municipios tratados y los del grupo de comparación y crear las ponderaciones que se emplearon para evaluar el efecto medio del tratamiento sobre los tratados (ATT) en el estimador de diferencias en diferencias. Hubo 2.771 hospitalizaciones por ACV en 2010 (0,51% de todas las hospitalizaciones) y 11.542 (2%) en 2019. Los municipios que aplicaron el PAS tuvieron un 18,37% menos de hospitalizaciones en comparación con sus homólogos del grupo de comparación. El impacto del programa en la reducción de las tasas de hospitalización fue gradualmente mayor entre los hombres (ATT: -0,1932) y entre las personas de 71 a 80 años (ATT: -0,1911). Todos los resultados fueron estadísticamente significativos al nivel del 5%. El PAS redujo la hospitalización por ACV en varios grupos de población, pero principalmente en aquellos en los que la prevalencia subyacente de ACV es mayor, lo que refuerza la importancia de las inversiones públicas en políticas de promoción de la salud diseñadas para impulsar cambios en los estilos de vida.

This study aimed to evaluate the impact of the Health Gym Program (HGP) on hospital admissions for stroke in the state of Pernambuco, Brazil. This policy impact evaluation used a quasi-experimental approach consisting of a difference-in-differences estimator, weighted by propensity score matching to deal with potential confounding variables. The study comprised socioeconomic, demographic, and epidemiological data from official Brazilian databases from 2010 to 2019. The treatment group was composed of the 134 municipalities that implemented the HGP since 2011. The 51 municipalities that did not were allocated to the comparison group. The nearest neighbor algorithm (N5) was used to pair treatment and comparison group municipalities and create the weights to evaluate the average treatment effect on the treated (ATT) in the difference-in-differences estimator. In 2010, 2,771 people were hospitalized for stroke (0.51% of all hospitalizations) and in 2019, 11,542 (2%). Municipalities that implemented the HGP had 18.37% fewer hospitalizations than their counterparts in the comparison group. The program’s impact in reducing hospitalization rates was incrementally greater among men (ATT: -0.1932) and those aged 71 to 80 years (ATT: -0.1911). All results were statistically significant at the 5% level. The HGP reduced hospitalization for stroke in several population groups, but primarily in those whose underlying prevalence of stroke is highest, reinforcing the importance of public investments in health promotion policies designed to encourage lifestyle changes.

https://doi.org/10.1590/0102-311xen012922

How many species of Mollusca are there in Brazil? A collective taxonomic effort to reveal this still unknown diversity
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Machado, Fabrizio M.

; Miranda, Marcel S.

; Salvador, Rodrigo B.

; Pimenta, Alexandre D.

; Côrtes, Mariana O.

; Gomes, Jaime A.J.

; Miyahira, Igor C.

; Agudo-Padrón, Ignacio

; Oliveira, Cléo D.C.

; Caetano, Carlos H.S.

; Coelho, Paulo R.S.

; D’Ávila, Sthefane

; Arruda, Eliane P. de

; Almeida, Sérgio M. de

; Gomes, Suzete R.

; Alvim, Juliana

; Galvão-Filho, Hilton

; L. Ferreira-Júnior, Augusto

; Marques, Rodrigo C.

; Martins, Inês

; Souza, Leonardo S. de

; Arruda, Janine O.

; Cavallari, Daniel C.

; Santos, Sonia B. dos

; Pedro, Natan C.

; Salles, Anna C. de A.

; Dornellas, Ana P.S.

; Lima, Tarcilla C. de

; Amaral, Vanessa S. do

; Silva, Fernanda S.

; Passos, Flávio D.

; Thiengo, Silvana S.

; Leite, Tatiana S.

; Simone, Luiz R.L.

Zoologia (Curitiba)

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2023, Volume 40 elocation e23026

Resumo: En | Texto: En | PDF: En

ABSTRACT The expression ‘you need to know to conserve’ is a well-known cliche among biologists. Documenting the richness of a group of organisms is the first step towards understanding biodiversity and preparing efficient conservation plans. In this context, many efforts have been made to quantify the number of species on Earth and estimate the number of species still unknown to science. A few countries have complete and integrated databases estimating the approximate number of species recorded for their territory, particularly in the Global South. In Brazil, a country of continental dimensions, revealing the richness of the second most diverse clade of invertebrates (=Mollusca) has been a goal of taxonomists. Recently, in an unprecedented, collective, and integrated effort among Brazilian malacologists, it was possible to estimate how many valid species of molluscs are there in Brazil. In this effort, more than 30 mollusc experts joined together to update the Taxonomic Catalogue of the Brazilian Fauna (TCBF), a governmental website that allows a quick and real-time updating of all Metazoan. So far, more than 5,000 updates have been made in TCBF, indicating the presence of 3,552 valid species of molluscs in Brazil, distributed among the main clades as follows: Caudofoveata (10 spp.), Solenogastres (6 spp.), Polyplacophora (35 spp.), Scaphopoda (43 spp.), Cephalopoda (92 spp.), Bivalvia (629 spp.) and Gastropoda (2,737 spp.). The present study, in addition to demonstrating for the first time the richness of Brazilian molluscs, also presents the state of the art of this important phylum of invertebrates highlighting its most representative and neglected groups.

https://doi.org/10.1590/s1984-4689.v40.e23026

Lemongrass Essential Oil (Cymbopogon citratus (DC) Stapf.) Seasonal Evaluation and Microencapsulation by Spray-Drying
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Silva, Thais Leticia Moreira da

; Rosa, Gabriela Iatczaki da

; Santos, Milena Aparecida Lorang dos

; Graf, Sara Lenz

; Maia, Beatriz Helena Lameiro de Noronha Sales

; Beltrame, Flávio Luís

; Ferrari, Priscileila Colerato

Brazilian Archives of Biology and Technology

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2023, Volume 66 Nº spe elocation e23230016

Resumo: En | Texto: En | PDF: En

Abstract Lemongrass (Cymbopogon citratus) is an aromatic plant of great significance in industries due to its essential oil characteristic aroma. Essential oils are concentrated plant extracts that evaporate when in contact with air and have low chemical stability, which can improve encapsulation techniques. This study aimed to evaluate the seasonal influence in the concentration of the predominant component citral of the essential oil of C. citratus and develop microparticles by spray drying containing this vegetal matrix. The lemongrass leaves were collected in the four seasons, and the essential oil was extracted by hydrodistillation. The chemical composition was determined by gas chromatography coupled with the mass spectrometry technique (GC-MS). Different proportions of arabic and guar gums were evaluated as encapsulating agents. Physicochemical analyses characterized the microparticle powder. GC-MS showed higher citral in the spring and summer (84.89% and 79.39%, respectively), and it was possible to identify a high amount of citral in the microparticles. Field-emission scanning electron microscopy showed agglomerate and collapsed microparticles. Fourier transform infrared spectroscopy suggested the essential oil encapsulation due to a band at 1675 cm-1 used as a reference, related to the acyclic monoterpenes of citral. X-ray diffraction showed the amorphous structure of the microparticles. Thermogravimetric curves of microparticles showed higher Tonset in microparticles than those observed for pure lemongrass essential oil, inferring that microencapsulation improved the thermal stability. This result confirms the lemongrass essential oil microencapsulation and its potential application in food products, drugs, or cosmetics.

https://doi.org/10.1590/1678-4324-ssbfar-2023230016

Brain-derived neurotrophic factor serum levels following ketamine and esketamine intervention for treatment-resistant depression: secondary analysis from a randomized trial
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Caliman-Fontes, Ana Teresa

; Leal, Gustavo C.

; Correia-Melo, Fernanda S.

; Paixao, Camilla S.

; Carvalho, Michelle S.

; Jesus-Nunes, Ana Paula

; Vieira, Flavia

; Magnavita, Guilherme

; Bandeira, Igor D.

; Mello, Rodrigo P.

; Beanes, Graziele

; Silva, Samantha S.

; Echegaray, Mariana

; Carvalho, Lucas P.

; Machado, Paulo

; Sampaio, Aline S.

; Cardoso, Taiane de A.

; Kapczinski, Flávio

; Lacerda, Acioly L. T.

; Quarantini, Lucas C.

Trends in Psychiatry and Psychotherapy

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2023, Volume 45 elocation e20210298

Resumo: En | Texto: En | PDF: En

Abstract Objectives Evidence suggests that ketamine’s influence on brain-derived neurotrophic factor (BDNF) might be involved in its mechanism of rapid antidepressant action. We aimed to evaluate the differential impact of ketamine and esketamine on serum BDNF levels and its association with response patterns in treatment-resistant depression (TRD). Methods Participants (n = 53) are from a randomized, double-blind clinical trial comparing the efficacy of single-dose ketamine (0.5mg/kg, n = 27) and esketamine (0.25mg/kg, n = 26) in TRD. Depression severity was assessed before and 24 hours, 72 hours, and 7 days after the intervention, using the Montgomery-Åsberg Depression Rating Scale (MADRS). Blood samples were collected before infusion, 24 hours, and 7 days afterwards. Results There were no significant changes in BDNF levels at post-infusion evaluation points, and no difference in BDNF levels comparing ketamine and esketamine. Both drugs exhibited similar therapeutic effect. There was no association between BDNF levels and response to treatment or severity of depressive symptoms. Conclusion There was no significant treatment impact on BDNF serum levels – neither with ketamine nor esketamine – despite therapeutic response. These results suggest that ketamine or esketamine intervention for TRD has no impact on BDNF levels measured at 24 hours and 7 days after the infusion. This clinical trial is registered on the Japan Primary Registries Network: UMIN000032355.

https://doi.org/10.47626/2237-6089-2021-0298

Air velocity spatial variability in open Compost-Bedded Pack Barn system with positive pressure ventilation
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OLIVEIRA, CARLOS EDUARDO A.

; TINÔCO, ILDA DE FÁTIMA F.

; DAMASCENO, FLÁVIO A.

; OLIVEIRA, VICTOR C. DE

; RODRIGUES, PEDRO HENRIQUE M.

; FERRAZ, GABRIEL A.S.

; SOUSA, FERNANDA C. DE

; ANDRADE, RAFAELLA R.

; NASCIMENTO, JOÃO ANTÔNIO C. DO

; SILVA, LEONARDO F. DA

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Supl. 1 elocation e20220415

Resumo: En | Texto: En | PDF: En

Abstract In Compost-Bedded Pack Barn (CBP) systems, air velocity is linked with the thermal comfort of housed dairy cattle and bedding quality and, therefore, assessing ventilation efficiency is essential. In this context, the objective of this study was to evaluate and characterize dependence and spatial distribution of air velocity at the 1.5 m height (vair,M) and at bedding level (vair,B) in an open CBP system with positive pressure ventilation. The study was conducted in 2021, in a facility located in the Zona da Mata region, Minas Gerais, Brazil. The facility area was divided into a mesh composed of 55 equidistant points, where vair,M and vair,B data were collected in the morning (09:00 a.m.) and afternoon (03:00 p.m.) periods, during three weeks in Brazilian winter. Geostatistics techniques were used to assess dependence and spatial distribution. In both periods evaluated, there were a strong occurrence of spatial dependence and non-uniform vair,M and vair,B distributions. The vair,M and vair,B values were lower than recommended (1.8 m∙s–1) in more than 65.0% of the area. Adequate ventilation levels were observed only in the first 20.0 m of the facility, from Southeast to Northwest, because of the fan lines present.

https://doi.org/10.1590/0001-3765202320220415

10.

Impact of the Health Gym Program on hospital admissions for stroke in the state of Pernambuco, Brazil
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Guarda, Flávio Renato Barros da

; Rodrigues, Bárbara Letícia Silvestre

; Silva, Rafaela Niels da

; Faria, Shirlley Jackllanny Martins de

; Silva, Paloma Beatriz Costa

; Silva Júnior, Redmilson Elias da

; Feitosa, Daíze Kelly da Silva

; Anokye, Nana Kwame

; Coyte, Peter C.

Cadernos de Saúde Pública

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2023, Volume 39 Nº 1 elocation e00012922

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0102-311xen012922

11.

Acai Residue as an Ecologic Filler to Reinforcement of Natural Rubber Biocomposites
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Araújo, Samara S.

; Santos, Gleyson T. A.

; Tolosa, Gabrieli R.

; Hiranobe, Carlos T.

; Budemberg, Eduardo R.

; Cabrera, Flávio C.

; Silva, Michael J. da

; Paim, Leonardo L.

; Job, Aldo E.

; Santos, Renivaldo J. dos

Materials Research

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2023, Volume 26 Supl. 1 elocation e20220505

Resumo: En | Texto: En | PDF: En

The biodiversity of plant resources is a renewable source that can use as a sustainable component in various applications. The use of vegetable waste as a filler element in polymeric composites is part of the solid waste management policy and the sustainable development of agribusiness. In this work, the natural rubber composites were prepared with acai seed in proportions of 0, 10, 20, 30, 40, and 50 phr (per hundred rubber). The composites were homogenized in an open cylinder mixer and characterized by rheometric, morphological, mechanical, and thermal tests. The addition of the organic fillers significantly reduced the vulcanization process time. Thermogravimetric analysis and infrared spectroscopy showed that the composites were thermally stable and showed no structure changes after the vulcanization process, respectively. The Lorenz-Parks method's evaluation of matrix/filler interactions showed a strong interaction between NR/Acai. The new biocomposite can replace non-ecological composites economically and sustainably.

https://doi.org/10.1590/1980-5373-mr-2022-0505

12.

EVALUATION OF AMMONIA SENSOR MODULES IN A COMPOST BARN SYSTEM DURING WINTER IN BRAZIL
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Oliveira, Victor C. de

; Tinôco, Ilda de F. F.

; Silva, Leonardo F. da

; Oliveira, Carlos E. A.

; Damasceno, Flávio A.

; Saraz, Jairo A. O.

Engenharia Agrícola

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2023, Volume 43 Nº 4 elocation e20230062

Resumo: En | Texto: En | PDF: En

ABSTRACT This study aimed to characterize the performance of three electrochemical ammonia sensor modules (MQ137, FECS44-100, and MIX2801) in comparison to standard equipment (iPMU) under atmospheric conditions of an open Compost Barn (CB) during the winter period in Brazil. The study was conducted in Cajuri (MG) over three days, collecting data from 06 am to 05 pm on ammonia concentration, temperature, relative humidity, and air velocity in the CB, specifically at the center of the bedding area. The evaluation period was divided into three parts: Period 1 (06 to 09 am); Period 2 (10 am to 01 pm); and Period 3 (02 pm to 05 pm). Recorded data were analyzed using descriptive statistics. It was observed that the greatest discrepancy among the readings occurred in Period 1 (for all sensor modules and the iPMU), due to air saturation conditions. In Periods 2 and 3, readings from the sensor modules closely matched those recorded by the iPMU. Throughout all periods, the MIX2801 showed the most significant discrepancies compared to the iPMU, whereas the MQ137 was the closest to the standard equipment. This finding suggests that the MQ137 is a viable option for use in CB facilities.

https://doi.org/10.1590/1809-4430-eng.agric.v43n4e20230062/2023

13.

Growth curve in elephant grass genotypes based on morpho-agronomic traits for energy production
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Vidal, Ana-Kesia F.

; Daher, Rogério F.

; Freitas, Rafael S.

; Stida, Wanessa F.

; Lédo, Francisco-José da S.

; Silva, Verônica B. da

; Entringer, Geovana C.

; Tardin, Flávio D.

; Gravina, Geraldo de A.

; Vivas, Marcelo

; Souza, Alexandre G. de

; Ambrósio, Moisés

; Santana, Josefa-Grasiela da S.

; Farias, João E.C.

Chilean journal of agricultural research

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Mar 2022, Volume 82 Nº 1 Páginas 78 - 87

Resumo: En | Texto: En | PDF: En

ABSTRACT The elephant grass (Cenchrus purpureus (Schumach.) Morrone) is one of the species with great prominence for energy production because of its favorable traits, such as high yield and short cycle, combined with several biomass quality characteristics. Therefore, this study intended to evaluate the morpho-agronomic traits of eight elephant grass genotypes under different cutting ages. A randomized block design with three replicates was applied to the experiment, and plots were composed of a 12 m long line divided into six subplots for each of the bimonthly cuts. Eight genotypes were evaluated in the plots, and the cutting ages (2, 4, 6, 8, 10, and 12-mo) were analyzed in the subplots. The following traits were assessed: DM yield, (DMY) percentage of DM, and average plant height (HEI). All genetic-statistical analyses were conducted using the Genes Program. The evaluated genotypes showed nonsignificant differences, indicating that, for the evaluated traits, these genotypes are genetically similar. Most genotypes presented linear effect of 2nd degree in the two assessment cuts, pointing they did not reach their maximum capacity of DMY in the time interval of the evaluated cuts. The maximum %DM achieved for the most genotypes occurred at about 9-mo age, while genotypes Vruckwona and BAG-86 at about 10-mo age. The maximum points for HEI trait were between 8 and 10-mo age. Increasing the cutting interval leads to increases in DM yield, with the 10-mo cutting age being the most efficient, resulting in higher yields.

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14.

Myonecrosis caused by Clostridium septicum in a horse from Southern Brazil
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Seeger, Marlane Geribone

; Silva, Gabriele Biavaschi

; Machado, Carolina Sleutjes

; Silva, Diego Rafael Palma da

; Corte, Flávio Desessards De La

; Vogel, Fernanda Silveira Flores

; Cargnelutti, Juliana Felipetto

Ciência Rural

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2022, Volume 52 Nº 11 elocation e20210736

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Mionecroses clostridiais são doenças altamente fatais, causadas por uma ou mais espécies de Clostridium sp. patogênicos. Entretanto, no músculo equino, a infecção pode produzir uma variedade de lesões e sinais clínicos. O presente relato descreve um caso de mionecrose aguda em um cavalo causada por Clostridium septicum, que apresentou uma evolução clínica favorável. Uma égua de seis anos foi internada em um hospital veterinário devido a um aumento de volume e claudicação no membro pélvico esquerdo, observado após injeção intramuscular de anti-inflamatório. O diagnóstico de mionecrose por C. septicum foi baseado nos achados clínicos e laboratoriais. Houve uma melhora significativa do animal após cinco meses de tratamento, permitindo que o mesmo fosse liberado do hospital veterinário. Considerando que as informações sobre C. septicum causadores de mionecroses em cavalos no Brasil são muito limitadas, este relato demonstra que o diagnóstico precoce e a implementação adequada do tratamento podem garantir uma melhora significativa e a recuperação dos animais afetados.

ABSTRACT: Clostridial myonecrosis is a highly fatal infectious disease of the muscle that is caused by pathogenic clostridia. When it occurs in equine muscle, the infection can cause a variety of clinical signs. The present report described a case of acute myonecrosis caused by Clostridium septicum in a horse, which had a favorable clinical evolution. A 6-year-old mare was admitted to a veterinary hospital due to increased volume and lameness in the left pelvic limb after an intramuscular injection of an anti-inflammatory drug. The diagnosis of myonecrosis caused by C. septicum was based on clinical and laboratory findings. The animal showed significant improvement after 5 months of treatment and was discharged from the hospital. There is very limited information regarding myonecrosis caused by C. septicum in horses in Brazil; our study showed that early diagnosis and prompt appropriate treatment can ensure significant improvement and recovery of affected animals.

https://doi.org/10.1590/0103-8478cr20210736

15.

Resistance of chickpea cultivars to Chloridea virescens (Lepidoptera: Noctuidae)
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Borella Júnior, Célio

; Correa, Fernanda

; Silva, Anderson Rodrigo da

; Siqueira, Ana Paula Silva

; Nascimento, Warley Marcos

; Almeida, André Cirilo de Sousa

; Jesus, Flávio Gonçalves de

Acta Scientiarum. Agronomy

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2022, Volume 44 elocation e54619

Resumo: En | Texto: En | PDF: En

ABSTRACT. Chickpea is a legume with nutrient-rich grains important for human feeding. Tobacco budworm, Chloridea virescens (Lepidoptera: Noctuidae), is one of the most major pests of chickpea (Cicer arietinum) in Brazil. This pest damages leaves, flowers, pods, and grains. Plant resistance to insects is an important tactic of pest management, which usually facilitates and reduce costs of implementing an Integrated Pest Management for farmers. Thus, this study aimed to evaluate the resistance in chickpea cultivars to C. virescens. Six chickpea cultivars were evaluated for antixenosis, initial antibiotic parameters, and behavior under field conditions. The cultivars BRS Kalifa and BRS Cícero were less attractive in a free-choice test, while Jamu 96 and BRS Kalifa were less attractive in a no-choice test. BRS Kalifa and BRS Toro leaves had a higher trichome density. Jamu 96 and BRS Toro had higher contents of oxalic and malic acids. C. virescens larvae in BRS Cícero, BRS Toro, and BRS Kalifa showed the lowest weights. Jamu 96 pods were the least damaged, and BRS Aleppo and Jamu 96 had the highest yields. The chickpea cultivars Jamu 96 and BRS Aleppo, which had resistance levels and mechanisms, can be used in integrated pest management programs to control C. virescens.

https://doi.org/10.4025/actasciagron.v44i1.54619

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