Abstract The aim of this study was to investigate the prevalence of unsatisfactory dental restorations on posterior primary teeth and associated factors in school children aged six to ten years. A cross-sectional study was conducted with children randomly selected from public schools in a small Brazilian town. Questionnaires were sent to the guardians addressing socioeconomic and behavioral aspects of the child. Oral examinations were performed at the schools to determine the quality of dental restorations, visible biofilm, and presence of moderate/extensive untreated caries (scores 3-6 ICDAS). This examination was performed by two previously trained and calibrated examiners. Associations were tested using multilevel logistic regression. Among the 400 children evaluated, 98 had restorations (217 teeth). The prevalence of unsatisfactory restorations was 34.6%. Restorations in amalgam were less likely to fail compared to those in glass ionomer cement (OR = 0.11; 95%CI: 0.02–0.49; p = 0.005). Children with moderate/extensive untreated caries were more likely to have unsatisfactory restorations (OR = 6.79; 95%CI: 2.20–20.93; p = 0.001). Children with a visible plaque index ≥ 20% were also more likely to have unsatisfactory restorations (OR = 2.28 95%CI: 1.05–4.92; p = 0.036). The prevalence of unsatisfactory restorations was high. The occurrence of this outcome was associated with restorative material, presence of caries, and visible plaque.

Resumo Fundamento A frequência cardíaca em repouso (FCR) pode ser uma ferramenta útil de triagem para o risco cardiovascular. Porém, os pontos de corte para FCR nunca foram descritos em populações jovens. Objetivo Estabelecer os pontos de corte para FCR em adolescentes brasileiros e analisar se há associação entre pontos de corte e fatores de risco cardiovascular. Métodos A amostra foi composta por 6.794 adolescentes (de 10 a 19 anos). A pressão arterial e a FCR foram avaliadas por dispositivo oscilométrico. Também foram avaliados o índice de massa corporal e a circunferência da cintura. Foi adotada a curva ROC para analisar a sensibilidade e especificidade, e as associações de FCR elevada com os fatores de risco cardiovascular foram analisadas por regressão logística binária. Foi considerado estatisticamente significante um valor de p < 0,05 para todas as análises. Resultados Os valores médios da FCR eram mais altos entre os participantes de 10 a 14 anos do naqueles de 15 a 19 anos, em meninos (p < 0,001) e meninas (< 0,001). Os pontos de corte de FCR propostos para detecção de fatores de risco cardiovascular foram significativos para meninos de 10 a 14 (> 92 bpm) e de 15 a 19 anos (> 82 bpm) e para meninas de 15 a 19 anos (> 82 bpm) (p < 0,05 para todos), enquanto nenhum ponto de corte foi identificado para as meninas de 10 a 14 anos (p > 0,05). Os pontos de corte propostos para a FCR foram associados com obesidade abdominal, sobrepeso e pressão arterial elevada em meninos e meninas. Os pontos de corte da FCR foram associados ao conjunto de fatores de risco cardiovascular em adolescentes de 15 a 19 anos. Conclusões Os pontes de corte propostos para a FCR foram associados com os fatores de risco cardiovascular em adolescentes.

Abstract Background Resting heart rate (RHR) may be a useful screening tool for cardiovascular risk. However, RHR cutoff points, an interesting clinical approach, have never been described in young populations. Objective To establish RHR cutoff points in Brazilian adolescents and to analyze whether cutoff points are associated with cardiovascular risk factors. Methods The sample was composed of 6,794 adolescents (10 to 19 years old). Blood pressure and RHR were assessed by oscillometric device. Body mass index and waist circumference were also assessed. Receiver operating characteristic curve was adopted to analyze the sensitivity and specificity, and associations of high RHR with cardiovascular risk factors were analyzed by binary logistic regression. A p value < 0.05 was considered statistically significant for all the analyses. Results Mean RHR values were higher among participants ages 10 to 14 years than 15 to 19 years, for boys (p < 0.001) and girls (< 0.001). The proposed RHR cutoff points for cardiovascular risk factors detection were significant for boys ages 10 to 14 (> 92 bpm) and 15 to 19 years (> 82 bpm), as well as for girls ages 15 to 19 years (> 82 bpm) (p < 0.05 for all), whereas no cutoff point was identified for girls ages 10 to 14 years (p > 0.05). Proposed RHR cutoff points were associated with abdominal obesity, overweight, and high blood pressure in boys in girls. RHR cutoff points were associated with the cluster of cardiovascular risk factors in adolescents ages 15 to 19 years. Conclusion The proposed RHR cutoff points were associated with cardiovascular risk factors in adolescents.

RESUMO Introdução: O uso do Nursing Activity Score permite correlacionar a carga de trabalho de enfermagem com os índices de avaliação prognóstica na unidade de terapia intensiva e auxiliar no desenvolvimento do processo de trabalho dos enfermeiros por meio do dimensionamento adequado da equipe. Objetivo: Analisar a associação entre variáveis clínicas e demográficas de pacientes com carga de trabalho de enfermagem em uma Unidade de Terapia Intensiva Oncológica. Métodos: Coorte prospectiva, realizada no Instituto Nacional de Câncer José Alencar Gomes da Silva, no período de setembro a dezembro de 2016. A coleta de dados inclui a mensuração da carga de trabalho por meio do Escore de Atividades de Enfermagem. Foi realizada análise estatística descritiva dos dados. Em seguida, a associação das variáveis qualitativas com o NAS foi testada pelo teste de Kruskal-Wallis e as variáveis quantitativas foram analisadas por análise de regressão múltipla. Para o tratamento dos dados, foram consideradas significância p = 0,05 e 95 % de confiança. Resultado: A carga total de trabalho encontrada (79,04 %) corresponde a 18 horas e 57 minutos de assistência a cada paciente em 24 horas. A média da condição de saída do paciente é dividida em sobreviventes e não sobreviventes, com uma pontuação de 74,19 % (DP = 11,54) e 126,64 % (DP = 17,62), respectivamente. Conclusão: Apenas as variáveis status de desempenho de Karnofsky e condição de saída foram significativamente associadas à carga de trabalho.

ABSTRACT Introduction: The use of the Nursing Activity Score (NAS) makes it possible to correlate the nursing workload with prognostic evaluation indices in the intensive care unit and helps in the development of the nurses' work process through the sizing of the appropriate personnel. Objective: To analyze the association between clinical and demographic variables about patients with a nursing workload in an oncology intensive care unit. Methods: Prospective cohort study carried out at José Alencar Gomes da Silva National Cancer Institute, from September to December 2016. The data collection includes the measurement of the workload through the Nursing Activities Score. A descriptive statistical analysis of the data was performed. Afterwards, the association between qualitative variables and the NAS was tested using the Kruskal-Wallis test and the quantitative variables were analyzed using multiple regression analysis. For data treatment, significance was considered (P = 0.05; confidence interval 95%). Result: The total workload found (79.04%) corresponds to 18 hours and 57 minutes of assistance to each patient within 24 hours. The mean for the discharge condition of the patients is divided into survivors and non-survivors, with a score of 74.19% (SD=11.54) and 126.64% (SD=17.62), respectively. Conclusion: Only Karnofsky performance state variables and discharge condition were significantly associated with workload.

RESUMEN Introducción: El uso del Puntaje de Actividades de Enfermería permite correlacionar la carga de trabajo de enfermería con los índices de evaluación pronóstica en la unidad de cuidados intensivos y ayuda en el desarrollo del proceso de trabajo de las enfermeras a través del dimensionamiento del personal apropiado. Objetivo: Analizar la asociación entre variables clínicas y demográficas de pacientes con carga de trabajo de enfermería en una Unidad de Cuidados Intensivos de Oncología. Métodos: Estudio de cohorte prospectiva, realizada en Instituto Nacional del Câncer José Alencar Gomes da Silva de septiembre a diciembre de 2016. La recolección de datos incluye la medición de la carga de trabajo a través del Puntaje de Actividades de Enfermería. Se realizó un análisis estadístico descriptivo de los datos. Después, se probó la asociación de variables cualitativas con NAS mediante la prueba de Kruskal-Wallis y se analizaron las variables cuantitativas mediante análisis de regresión múltiple. Para el tratamiento de los datos, se consideró una significancia p = 0,05 y un 95 % de confianza. Resultado: La carga de trabajo total encontrada (79,04 %) corresponde a 18 horas y 57 minutos de asistencia a cada paciente dentro de las 24 horas. La media para la condición de salida de los pacientes se divide en sobrevivientes y no sobrevivientes, con un puntaje de 74,19 % (SD = 11,54) y 126,64 % (SD = 17,62), respectivamente. Conclusión: Solo las variables de estado de rendimiento de Karnofsky y la condición de salida se asociaron significativamente con la carga de trabajo.

Abstract The aim of this study was to evaluate the association between number of cavitated dental caries in adolescents and family cohesion, drug use, sociodemographic factors and visits to the dentist. A cross-sectional study was conducted with 746 adolescents aged 15 to 19 years from Campina Grande, Brazil. The parents answered a questionnaire addressing sociodemographic data, and the adolescents answered questionnaires on drug use, type of family cohesion and visits to the dentist. Two examiners underwent training and calibration exercises (K > 0.80) to diagnose dental caries using the Nyvad criteria. A directed acyclic graph was created to select the variables to be controlled in the statistical model. Associations between the independent variables and the outcome were determined using robust Poisson Regression analysis for complex samples (α = 5%). Rate ratios (RR) and 95% confidence intervals (CI) were calculated. The prevalence of dental caries and cavitated lesions among the adolescents was 92.8% and 41.6%, respectively. The following variables remained associated with the number of cavitated lesions in the multivariate analysis: disengaged (RR: 6.30; 95%CI: 1.24–31.88; p = 0.028 ), separated (RR: 4.80; 95%CI: 1.03–22.35; p = 0.046) and connected (RR: 5.23; 95%CI: 1.27–21.59; p = 0.024) levels of family cohesion, and high social class (RR: 0.55; 95%CI: 0.39–0.76; p = 0.001). In conclusion, this paper posits that adolescents with a lower socioeconomic status, and those whose family cohesion was classified as disengaged, separated or connected, had a larger number of cavitated lesions.

Resumo O objetivo desse estudo foi verificar a associação entre o uso e a necessidade de prótese dentária e qualidade de vida em idosos de um Centro de Referência de Atenção ao Idoso no Nordeste do Brasil. Um estudo transversal foi desenvolvido com a participação de 199 idosos de ambos os sexos. Os dados clínicos foram coletados conforme a Organização Mundial de Saúde, através de exames clínicos e questionário sobre dados socioeconômicos, índice Oral Health Impact Profile (OHIP-14), por um examinador previamente treinado (kappa=0,91). Os dados foram analisados pelo Mann-Whitney, regressão de Poisson (p>0,05). A amostra consistiu de 84,9% de mulheres, com idade média de 70,02 (dp±6,50) anos. Houve associação independente entre a qualidade de vida e as covariáveis sexo e necessidade de prótese. Idosos do sexo masculino apresentaram menores valores do escore (RP=0,734; p=0,011) do que as mulheres. Indivíduos sem necessidade normativa de prótese dentária apresentaram menores valores do OHIP-14 (RP=0,767; p=0,003) do que aqueles com necessidade.

Abstract This study aimed to explore the association between use and need of dental prostheses to the quality of life in elderly individuals in a Referral Center for Elderly Care in the northeastern of Brazil. A cross-sectional study was developed with 199 elderlies of both sexes. Data were collected from clinical examinations (WHO criteria) and a questionnaire regarding socioeconomic status, Oral Health Impact Profile index (OHIP-14) by a single calibrated examiner with Kappa = 0.91. Data were analyzed using Mann-Whitney test, Poisson regression (p<0,05). The sample consisted of 84.9% women, mean age of 70.02 (sd±6.50) years. There was an independent association between quality of life and the covariates sex and need of dental prostheses. Men showed lower values of the score (PR = 0.734, p = 0.011) than women. Individuals without normative need for dental prostheses showed lower values of OHIP-14 (PR = 0.767; p = 0.003) than those in need.

Resumo O objetivo desse estudo foi verificar a associação entre o uso e a necessidade de prótese dentária e qualidade de vida em idosos de um Centro de Referência de Atenção ao Idoso no Nordeste do Brasil. Um estudo transversal foi desenvolvido com a participação de 199 idosos de ambos os sexos. Os dados clínicos foram coletados conforme a Organização Mundial de Saúde, através de exames clínicos e questionário sobre dados socioeconômicos, índice Oral Health Impact Profile (OHIP-14), por um examinador previamente treinado (kappa=0,91). Os dados foram analisados pelo Mann-Whitney, regressão de Poisson (p>0,05). A amostra consistiu de 84,9% de mulheres, com idade média de 70,02 (dp±6,50) anos. Houve associação independente entre a qualidade de vida e as covariáveis sexo e necessidade de prótese. Idosos do sexo masculino apresentaram menores valores do escore (RP=0,734; p=0,011) do que as mulheres. Indivíduos sem necessidade normativa de prótese dentária apresentaram menores valores do OHIP-14 (RP=0,767; p=0,003) do que aqueles com necessidade.

Abstract This study aimed to explore the association between use and need of dental prostheses to the quality of life in elderly individuals in a Referral Center for Elderly Care in the northeastern of Brazil. A cross-sectional study was developed with 199 elderlies of both sexes. Data were collected from clinical examinations (WHO criteria) and a questionnaire regarding socioeconomic status, Oral Health Impact Profile index (OHIP-14) by a single calibrated examiner with Kappa = 0.91. Data were analyzed using Mann-Whitney test, Poisson regression (p<0,05). The sample consisted of 84.9% women, mean age of 70.02 (sd±6.50) years. There was an independent association between quality of life and the covariates sex and need of dental prostheses. Men showed lower values of the score (PR = 0.734, p = 0.011) than women. Individuals without normative need for dental prostheses showed lower values of OHIP-14 (PR = 0.767; p = 0.003) than those in need.

ABSTRACT Objective Investigate the therapeutic response of acromegaly patients to pegvisomant (PEGV) in a real-life, Brazilian multicenter study. Subjects and methods Characteristics of acromegaly patients treated with PEGV were reviewed at diagnosis, just before and during treatment. All patients with at least two IGF-I measurements on PEGV were included. Efficacy was defined as any normal IGF-I measurement during treatment. Safety data were reviewed. Predictors of response were determined by comparing controlled versus uncontrolled patients. Results 109 patients [61 women; median age at diagnosis 34 years; 95.3% macroadenomas] from 10 Brazilian centers were studied. Previous treatment included surgery (89%), radiotherapy (34%), somatostatin receptor ligands (99%), and cabergoline (67%). Before PEGV, median levels of GH, IGF-I and IGF-I % of upper limit of normal were 4.3 µg/L, 613 ng/mL, and 209%, respectively. Pre-diabetes/diabetes was present in 48.6% and tumor remnant in 71% of patients. Initial dose was 10 mg/day in all except 4 cases, maximum dose was 30 mg/day, and median exposure time was 30.5 months. PEGV was used as monotherapy in 11% of cases. Normal IGF-I levels was obtained in 74.1% of patients. Glycemic control improved in 56.6% of patients with pre-diabetes/diabetes. Exposure time, pre-treatment GH and IGF-I levels were predictors of response. Tumor enlargement occurred in 6.5% and elevation of liver enzymes in 9.2%. PEGV was discontinued in 6 patients and 3 deaths unrelated to the drug were reported. Conclusions In a real-life scenario, PEGV is a highly effective and safe treatment for acromegaly patients not controlled with other therapies.

OBJECTIVE: The aim of this study was to evaluate the effect of oral tamoxifen treatment on the number of myofibroblasts present during the healing process after experimental bile duct injury. METHODS: The sample consisted of 16 pigs that were divided into two groups (the control and study groups). Incisions and suturing of the bile ducts were performed in the two groups. Tamoxifen (20 mg/day) was administered only to the study group. The animals were sacrificed after 30 days. Quantification of myofibroblasts in the biliary ducts was made through immunohistochemistry analysis using anti-alpha smooth muscle actin of the smooth muscle antibody. Immunohistochemical quantification was performed using a digital image system. RESULTS: In the animals treated with tamoxifen (20 mg/day), there was a significant reduction in immunostaining for alpha smooth muscle actin compared with the control group (0.1155 vs. 0.2021, p = 0.046). CONCLUSION: Tamoxifen reduced the expression of alpha smooth muscle actin in the healing tissue after bile duct injury, suggesting a decrease in myofibroblasts in the scarred area of the pig biliary tract. These data suggest that tamoxifen could be used in the prevention of biliary tract stenosis after bile duct surgeries.

OBJETIVO: Comparar dois modelos de hipertensão pulmonar (monocrotalina e monocrotalina+pneumonectomia) em relação à gravidade hemodinâmica, estrutura de artérias pulmonares, marcadores inflamatórios (IL-1 e PDGF) e sobrevida em 45 dias. MÉTODOS: Foram utilizados 80 ratos Sprague-Dawley em dois protocolos de estudo: análise estrutural e de sobrevida. Os animais foram divididos em quatro grupos: controle, monocrotalina (M), pneumonectomia (P) e monocrotalina+pneumonectomia (M+P). Para a análise estrutural, 40 animais (10/grupo) foram cateterizados após 28 dias para a medição dos valores hemodinâmicos e sacrificados, obtendo-se tecidos cardíaco e pulmonar. O ventrículo direito (VD) foi dissecado do septo interventricular (SI), e a relação do peso do VD e do peso do ventrículo esquerdo (VE) com o SI foi obtida como índice de hipertrofia de VD. No tecido pulmonar, foram realizadas análises histológicas e dosados IL-1 e PDGF por ELISA. Para o estudo de sobrevida, 40 animais (10/grupo) foram observados por 45 dias. RESULTADOS: Os grupos M e M+P apresentaram hipertensão pulmonar em relação aos demais. Houve um aumento significativo da relação VD/VE+S no grupo M+P em relação aos demais. Não houve diferenças significativas entre os grupos M e M+P quanto à área da camada média das artérias pulmonares, dosagens de IL-1 e PDGF ou sobrevida. CONCLUSÕES: Baseados nos resultados, não podemos afirmar que o modelo de monocrotalina+pneumonectomia é superior ao modelo de monocrotalina.

OBJECTIVE: To compare two models of pulmonary hypertension (monocrotaline and monocrotaline+pneumonectomy) regarding hemodynamic severity, structure of pulmonary arteries, inflammatory markers (IL-1 and PDGF), and 45-day survival. METHODS: We used 80 Sprague-Dawley rats in two study protocols: structural analysis; and survival analysis. The rats were divided into four groups: control; monocrotaline (M), pneumonectomy (P), and monocrotaline+pneumonectomy (M+P). In the structural analysis protocol, 40 rats (10/group) were catheterized for the determination of hemodynamic variables, followed by euthanasia for the removal of heart and lung tissue. The right ventricle (RV) was dissected from the interventricular septum (IS), and the ratio between RV weight and the weight of the left ventricle (LV) plus IS (RV/LV+IS) was taken as the index of RV hypertrophy. In lung tissues, we performed histological analyses, as well as using ELISA to determine IL-1 and PDGF levels. In the survival protocol, 40 animals (10/group) were followed for 45 days. RESULTS: The M and M+P rats developed pulmonary hypertension, whereas the control and P rats did not. The RV/LV+IS ratio was significantly higher in M+P rats than in M rats, as well as being significantly higher in M and M+P rats than in control and P rats. There were no significant differences between the M and M+P rats regarding the area of the medial layer of the pulmonary arteries; IL-1 and PDGF levels; or survival. CONCLUSIONS: On the basis of our results, we cannot conclude that the monocrotaline+pneumonectomy model is superior to the monocrotaline model.

Relata-se a intoxicação natural por Sida carpinifolia (guanxuma, chá-da-índia) em bovinos no Rio Grande do Sul. Foram afetados cinco bovinos no período 2001-2008. O quadro clínico foi caracterizado por emagrecimento, incoordenação, dificuldade de locomoção, tremores generalizados, quedas frequentes e morte. Microscopicamente, as principais alterações foram vacuolização dos neurônios de Purkinje do cerebelo, das células acinares do pâncreas e das células foliculares da tireoide. A microscopia eletrônica evidenciou vacúolos com conteúdo finamente granulado e delimitado por membrana. Na lectina-histoquímica, observou-se marcação em neurônios com as lectinas Concanavalia ensiformis (Con-A), Triticum vulgaris (WGA) e Succinyl Triticum vulgaris (sWGA).

This paper reports the natural poisoning by Sida carpinifolia (guanxuma, chá-da-índia) in cattle in Rio Grande do Sul, Brazil. Five cattle were affected in the period 2001-2008. Clinical signs included weight loss, incoordination, walking difficulty, generalized tremors, frequent falls, and death. Microscopically, the main changes were vacuolation of Purkinje neurons in the cerebellum, pancreatic acinar cells, and thyroid follicular cells. Transmission electron microscopy revealed vacuoles bordered by membrane containing finely granular material. Lectin histochemistry showed positive staining in neurons with the lectins Concanavalia ensiformis (Con-A), Triticum vulgaris (WGA), and Succinyl Triticum vulgaris (sWGA).

OBJETIVO: Avaliar o efeito do tratamento convencional da constipação crônica funcional no tempo de trânsito colônico total e segmentar e no tempo de trânsito orocecal. MÉTODOS: Foram incluídos 34 pacientes com constipação funcional atendidos consecutivamente em ambulatório especializado. O tempo de trânsito colônico total e segmentar foi avaliado com marcadores radiopacos. O tempo de trânsito orocecal da lactulose e do feijão foi avaliado com teste do hidrogênio no ar expirado. O tratamento constou de desimpactação, orientações gerais e de consumo de dieta rica em fibra alimentar e administração de óleo mineral. RESULTADOS: Na admissão, dismotilidade colônica foi encontrada em 71,9% (23/32) dos pacientes. Todos os pacientes que realizaram corretamente o tratamento apresentaram melhora clínica na sexta semana do tratamento quando 82,6% (19/23) daqueles com dismotilidade na admissão apresentaram normalização ou diminuição da gravidade no padrão de trânsito colônico. Observou-se redução do tempo de trânsito (medianas) entre a admissão e a oitava semana de tratamento: trânsito orocecal da lactulose (de 70 para 50 minutos, p = 0,002), orocecal do feijão (de 240 para 220 minutos, p = 0,002) e colônico total (de 69,5 para 37,0 horas, p = 0,001). A necessidade de uso de óleo mineral para controle da constipação aos 12 meses de tratamento associou-se com persistência de trânsito colônico total superior a 62 horas na oitava semana de tratamento (p = 0,014). CONCLUSÃO: O programa terapêutico convencional proporcionou bons resultados independentemente da presença ou não de dismotilidade colônica na admissão ao estudo. As anormalidades da motilidade digestiva na constipação funcional da criança podem apresentar reversibilidade e ser de natureza secundária.

OBJECTIVE: To evaluate the effects of conventional treatment of chronic functional constipation on total and segmental colonic transit times and on orocecal transit time. METHODS: A total of 34 consecutive patients with functional constipation attending a specialized outpatient clinic were included in the study. Total and segmental colonic transit times were assessed using radiopaque markers. Hydrogen breath test was used to evaluate lactulose and bean orocecal transit times. Treatment consisted of disimpaction, general and dietary fiber intake instruction, and mineral oil administration. RESULTS: At admission, colonic dysmotility was found in 71.9% (23/32) of patients. All patients who complied with the treatment showed improvement of clinical symptoms after 6 weeks of treatment, when 82.6% (19/23) of those with dysmotility at admission returned to normal or reduced the severity of colonic transit patterns. Transit time decreased (medians) between admission and eighth week of treatment: lactulose orocecal transit (from 70 to 50 minutes, p = 0.002), bean orocecal transit (from 240 to 220 minutes, p = 0.002), and total colonic transit (from 69.5 to 37.0 hours, p = 0.001). The need for mineral oil therapy for constipation after a 12-month treatment was associated with persistence of total colonic transit higher than 62 hours at the eighth week of treatment (p = 0.014). CONCLUSION: The conventional therapeutic approach yielded good results regardless of the presence or not of colonic dysmotility at inclusion in the study. Digestive tract motility abnormalities in functionally constipated children may be reversed, and may be secondary to constipation.

OBJETIVO: Analisar fatores prognósticos na sobrevida livre de doença e específica dos pacientes com carcinomas de células de Hürthle. MÉTODO: Estudo retrospectivo de 28 pacientes tratados na Seção de Cirurgia de Cabeça e Pescoço do HCI - INCa, objetivando coletar dados demográficos, clínicos e histopatológicos e relacioná-los com a sobrevida livre de doença e sobrevida global específica. O estadiamento foi realizado conforme a AJCC de 2002. Para análise estatística foi utilizado o programa Epi info 2002, considerando-se significativo estatisticamente o valor de p < 0,05. A análise da curva de sobrevida foi realizada utilizando-se o método de Kaplan-Meyer. O tempo médio de seguimento foi de 69,3 meses (10 - 230 meses). RESULTADOS: Foram avaliados 28 pacientes, com idade média de 50,8 anos. As variáveis que apresentaram impacto prognóstico quanto a recidiva foram o estágio mais avançado da doença (p = 0,03), a presença de metástase a distância (p = 0,03 e principalmente o padrão histológico de invasão maciça (p = 0,0027). Quando relacionado as variáveis estudadas com a mortalidade, o padrão de invasão histológica maciça (p = 0,02), o maior tamanho do tumor (p = 0,013) e principalmente a presença de metástases a distância (p = 0,0056) apresentaram relação com significância estatística. A sobrevida livre de doença foi de 72% e 55% e a sobrevida global de 87% e 77% em 5 e 10 anos respectivamente. CONCLUSÃO: A presença de metástase à distância e o padrão histológico de invasão maciça apresentaram relação estatisticamente significativa com a sobrevida livre de doença e específica.

OBJECTIVE: Analyze prognostic factors for disease free survival and specific survival in patients with Hurthle Cell Carcinoma. METHODS: We analyzed, retrospectively, the files of 28 patients treated in the Service of Head and Neck Surgery of the Brazilian National Cancer Institute/INCA from January 1983 to December 2002. Data regarding demographics, clinical aspects, therapeutics and histopathology were collected and related to disease-free survival and disease-specific survival. Patients were classified according to the AJCC 2002 staging system. Data was analyzed by the Epi Info 2002 software. Survival was analyzed by the Kaplan-Meier actuarial method. The median follow-up time was 69 months (range from 10 to 230). RESULTS: Advanced stages (p=.03), distant metastases (p=.03) and, particularly, the pattern of capsular invasion (widely invasive) (p=.0027) influenced negatively the prognosis in the disease-free survival. Analyzing the relationship between specific survival, the pattern of capsular invasion (widely invasive) (p=.02), T stage (p=.013) and, particularly, the presence of distant metastases (p=.0056) presented statistical significance. Five and 10 year disease-free survival was 72% and 55%, respectively, and 5 and 10 year disease-specific survival was 87% and 77%, respectively. CONCLUSION: The presence of distant metastases and widely invasive tumors were the most important negative prognostic factors associated with Hurthle Cell Carcinomas in our study.

Casos de tripanossomíase por Trypanosoma evansi foram diagnosticados em eqüinos no Rio Grande do Sul entre 2003 e 2004. Em uma propriedade (Propriedade A) com 125 eqüinos, 52 morreram. A Propriedade A recebeu ao redor de 80 éguas de outras propriedades para cobertura. Dessas, 66 adoeceram e 56 morreram após voltarem para suas propriedades de origem. A doença clínica observada em 21 eqüinos caracterizava-se por emagrecimento (apesar de apetite voraz), letargia, incoordenação e instabilidade dos membros pélvicos, atrofia das grandes massas musculares dos membros pélvicos, fraqueza muscular e palidez das mucosas. Exemplares de T. evansi foram observados na corrente sangüínea de 4 eqüinos. Anemia normocítica normo-crômica, com hematócritos que variavam de 15-31%, e leuco-citose por linfocitose associada à presença de linfócitos atípicos foram observadas em vários eqüinos. Altos níveis de anticorpos contra T. evansi foram detectados em 6 eqüinos da Propriedade A. Oito eqüinos desenvolveram um quadro neurológico encefálico caracterizado por andar em círculos, ataxia, cegueira, hiperexcitabilidade, quedas, embotamento, déficits proprioceptivos e desvio da cabeça. Um eqüino desenvolveu "posição de cão sentado". Nas 13 necropsias, havia espleno-megalia, linfadenomegalia, hiperplasia linfóide no baço e linfo-nodo, atrofia das grandes massas musculares dos membros pélvicos, edema e malacia na substância branca e cinzenta do encéfalo. Histologicamente, uma panencefalite devastadora foi observada nos 7 casos e caracterizada por marcado edema, desmielinização, necrose e infiltrado perivascular de 6-10 camadas de células linfoplasmocitárias afetando tanto a substância branca quanto a cinzenta. Muitos plasmócitos do infiltrado inflamatório continham numerosos grânulos eosinofílicos no citoplasma (células de Mott). Lesões semelhantes foram observadas na medula espinhal do eqüino que desenvolveu "posição de cão sentado". Os encéfalos de 5 eqüinos com quadro encefálico foram submetidos à técnica de imunoistoquímica estrepto-avidina-biotina; em todos eles observou-se a marcação de números moderados ou elevados de espécimes de T. evansi pelo anticorpo específico nos espaços intravasculares e na neurópila. Os aspectos epidemiológicos, clínicos, hematológicos e patológicos da tripanossomíase por T. evansi em eqüinos são discutidos.

Cases of trypanosomiasis by Trypanosoma evansi were diagnosed in horses in the state of Rio Grande do Sul, Brazil, between 2003 and 2004. In one stud farm (Farm A) with 125 horses, 52 died. Additionally, around 80 mares were sent to Farm A to be bred. Of those, 66 became ill and 56 died after being returned to their farms of origin. Twenty one horses clinically affected by the disease were observed. Clinical signs included loss of weight (despite voracious appetite), lethargy, incoordination and instability of hindlimbs, atrophy of the large muscles of the hindlimbs, muscle weakness and paleness of mucosae. Specimens of T. evansi were detected in the blood drawn from four affected horses. Normocytic normochromic anemia with PCVs ranging from 15 to 31%, leucocytosis due to lymphocytosis associated to large atypical lymphocytes was observed in several affected horses. High levels of antibodies against T. evansi were detected in the serum of six horses from Farm A. Eight horses presented encephalic neurological signs such as circling, ataxia, blindness, excitation, falls, listlessness, proprioception deficits and head tilt. One horse assumed a "dog-seating position". Necropsy findings included muscle atrophy, enlargement and lymphoid hyperplasia of the spleen and lymphnodes, edema and softening of the white and grey matter of the brain. Histologically, an overwhelming necrotizing panencephalitis was observed in the seven horses with encephalic signs. This panencephalitis was characterized by marked edema, demyelination and necrosis and perivascular infiltrates of 6-10 layers of lymphocytes and plasm cells affecting both the white and gray matter. Several plasm cells in the inflammatory infiltrate contained numerous eosinophilic globules in their cytoplasm (Mott cells). Similar histological lesions were observed in the spinal cord of the horse with the "dog-seating position". The brains of five horses with the encephalic signs were submitted to immunohistochemistry stain by the streptavidin-biotin technique. In all of those five brains moderate to abundant specimens of T. evansi in the perivascular spaces and neuropile were marked by the specific antibody. Epidemiological, clinical, hematological, and pathological aspects of equine trypanosomiasis caused by T. evansi are discussed.