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Abstract Objectives Evidence suggests that ketamine’s influence on brain-derived neurotrophic factor (BDNF) might be involved in its mechanism of rapid antidepressant action. We aimed to evaluate the differential impact of ketamine and esketamine on serum BDNF levels and its association with response patterns in treatment-resistant depression (TRD). Methods Participants (n = 53) are from a randomized, double-blind clinical trial comparing the efficacy of single-dose ketamine (0.5mg/kg, n = 27) and esketamine (0.25mg/kg, n = 26) in TRD. Depression severity was assessed before and 24 hours, 72 hours, and 7 days after the intervention, using the Montgomery-Åsberg Depression Rating Scale (MADRS). Blood samples were collected before infusion, 24 hours, and 7 days afterwards. Results There were no significant changes in BDNF levels at post-infusion evaluation points, and no difference in BDNF levels comparing ketamine and esketamine. Both drugs exhibited similar therapeutic effect. There was no association between BDNF levels and response to treatment or severity of depressive symptoms. Conclusion There was no significant treatment impact on BDNF serum levels – neither with ketamine nor esketamine – despite therapeutic response. These results suggest that ketamine or esketamine intervention for TRD has no impact on BDNF levels measured at 24 hours and 7 days after the infusion. This clinical trial is registered on the Japan Primary Registries Network: UMIN000032355.

https://doi.org/10.47626/2237-6089-2021-0298

New records of the Neotropical genus Phaonantho Albuquerque (Diptera: Anthomyiidae)
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Gomes, Lucas Roberto Pereira

; Carvalho, Claudio José Barros de

Papéis Avulsos de Zoologia

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2023, Volumen 63 elocation e202363041

Resumen: En | Texto: En | PDF: En

Abstract The genus Phaonantho Albuquerque (Anthomyiidae) comprises three species: P. mallochi (Curran), P. benevola Couri, and P. sordilloae Pamplona & Couri. These species are distributed in the neotropics. In this study, we updated the distributional knowledge for Phaonantho species, including the first record of the genus in Bolivia, Paraguay, Peru, and Mexico, and additional new records to Brazil.

https://doi.org/10.11606/1807-0205/2023.63.041

Art and science: impact of semioccluded vocal tract exercises and choral singing on quality of life in subjects with congenital GH deficiency
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Andrade, Bruna M. R. de

; Valença, Eugenia H. O.

; Salvatori, Roberto

; Oliveira Neto, Luiz A.

; Souza, Anita H. O.

; Oliveira, Alaíde H. A.

; Oliveira, Mario C.P.

; Melo, Enaldo V.

; Carvalho, Susana de

; Sales, Neuza J

; Monteiro, Gisane C.

; Lima, José Marcel de

; Annunziato, Marcos Felipe Harder

; Mannis, Guilherme Daniel Breternitz

; Souza, Lucas E. de A.

; Goes, Yasmin D.

; Carvalho, Thayza S.

; Farias, Celiane de

; Santos, Michela P. dos

; Cardoso, Gabriela P. F.

; Sousa, Carla S. Pereira

; Santana, Julia Rodrigues

; Sales, Ester Almeida

; d’Avila, Jeferson Sampaio

; Aguiar-Oliveira, Manuel H.

Archives of Endocrinology and Metabolism

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Abr 2022, Volumen 66 Nº 2 Paginas 198 - 205

Resumen: En | Texto: En | PDF: En

ABSTRACT Objectives: Currently, not much is known about the interactions between voice and growth hormone (GH). We have described large kindred with isolated GH deficiency (IGHD) due to a GHRH receptor mutation, resulting in severe short stature and high-pitched voice. These IGHD individuals have little interest in GH treatment, as they consider themselves “short long-lived people”, rather than patients. Interestingly, they report normal general quality of life, but they rate their Voice-Related Quality of Life (V-RQOL) as low. Here, we assessed the social and auditory-perceptual impacts of artistic-intervention voice therapy with semioccluded vocal tract exercises (SOVTE) and choral singing, on their voices. Material and methods: Seventeen GH-naïve adult IGHD individuals were enrolled in a single-arm interventional pre-post study with 13 weekly sessions of choir singing over 90 days. Outcome measures were V-RQOL scores, self-assessment of voice, and auditory-perceptual analysis (GRBAS scale, G: grade of the severity of dysphonia; R: roughness; B: breathiness; A: asthenia; and S: strain). Results: Marked improvements in total (p = 0.0001), physical (p = 0.0002), and socioemotional (p = 0.0001) V-RQOL scores and in self-assessment of voice (p = 0.004) were found. The general grades of vocal deviation (p = 0.0001), roughness (p = 0.0001), breathiness (p = 0.0001) and strain (p = 0.0001) exhibited accentuated reductions. Conclusions: Voice therapy with semioccluded vocal tract exercises and choral training improved social impact and perceptual voice assessments in IGHD subjects and markedly improved their voice-related quality of life. This is particularly important in a setting where GH replacement therapy is not widely accepted.

https://doi.org/10.20945/2359-3997000000449

[SciELO Preprints] - Peperomia Ruiz Pav. (Piperaceae) da Reserva Biológica do Tinguá, RJ, Brasil
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Rodrigues, Lucas Carvalho Gomes Queiroz, George Azevedo de Guimarães, Elsie Franklin

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Fecha de publicación: 2021-05-21

Resumen: En Pt

Peperomia Ruiz amp; Pav. is the second largest genus of Piperaceae with about 1,600 to 1,700 species in the world, with greater diversity in the Neotropics and with great representation in Brazil. The objective of the work was to identify as Peperomia Ruiz amp; Pav. species present in the Reserva Biológica do Tinguá, carrying out taxonomic treatment and comments. The REBIO of Tinguá is a Federal Conservation Unit of Integral Protection, located in the State of Rio de Janeiro and inserted in the Atlantic Forest biome. There have been found 14 taxa in REBIO of Tinguá: Peperomia alata Ruiz amp; Pav.; P. catharinae Miq.; P. corcovadensis Gardner; P. dichotoma Regel; P. glabella (Sw.) A. Dietr. var. glabella; P. glabella var. nervulosa (C. DC.) Yunck.; P. glabella var. nigropunctata (Miq.) Dahlst.; P. glazioui C. DC.; P. nitida Dahlst.; P. obtusifolia (L.) A. Dietr.; P. quadrifolia (L.) Kunth; P. rotundifolia (L.) Kunth; P. tetraphylla (G. Forst.) Hook. amp; Arn.; P. urocarpa Fisch. amp; C. A. Mey.

Peperomia Ruiz amp; Pav. é o segundo maior gênero de Piperaceae com cerca de 1.600 a 1.700 espécies no mundo, com 177 ocorrentes no Brasil. O objetivo do trabalho foi identificaras espécies de Peperomia Ruiz amp; Pav. presentes na Reserva Biológica do Tinguá, realizando tratamento taxonômico e comentários. A REBIO do Tinguá é uma Unidade de Conservação Federal de proteção integral, localizada no Estado do Rio de Janeiro e inserida no bioma Mata Atlântica. Foram encontrados 14 táxons na Reserva Biológica do Tinguá: Peperomia alata Ruiz amp; Pav.; P. catharinae Miq.; P. corcovadensis Gardner; P. dichotoma Regel; P. glabella (Sw.) A. Dietr. var. glabella; P. glabella var. nervulosa (C. DC.) Yunck.; P.glabella var. nigropunctata (Miq.) Dahlst.; P. glazioui C. DC.; P. nitida Dahlst.; P. obtusifolia (L.) A. Dietr.; P. quadrifolia (L.) Kunth; P. rotundifolia (L.) Kunth; P. tetraphylla (G. Forst.) Hook. amp; Arn.; P. urocarpa Fisch. amp; C. A. Mey.

https://doi.org/10.1590/2236-8906-38/2020

Peperomia Ruiz & Pav. (Piperaceae) da Reserva Biológica do Tinguá, RJ, Brasil
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Rodrigues, Lucas Carvalho Gomes

; Queiroz, George Azevedo de

; Guimarães, Elsie Franklin

Hoehnea

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2021, Volumen 48 elocation e382020

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Peperomia Ruiz & Pav. é o segundo maior gênero de Piperaceae com cerca de 1.600 a 1.700 espécies no mundo, com 177 ocorrentes no Brasil. O objetivo do trabalho foi identificaras espécies de Peperomia Ruiz & Pav. presentes na Reserva Biológica do Tinguá, realizando tratamento taxonômico e comentários. A REBIO do Tinguá é uma Unidade de Conservação Federal de proteção integral, localizada no Estado do Rio de Janeiro e inserida no bioma Mata Atlântica. Foram encontrados 14 táxons na Reserva Biológica do Tinguá: Peperomia alata Ruiz & Pav.; P. catharinae Miq.; P. corcovadensis Gardner; P. dichotoma Regel; P. glabella (Sw.) A. Dietr. var. glabella; P. glabella var. nervulosa (C. DC.) Yunck.; P.glabella var. nigropunctata (Miq.) Dahlst.; P. glazioui C. DC.; P. nitida Dahlst.; P. obtusifolia (L.) A. Dietr.; P. quadrifolia (L.) Kunth; P. rotundifolia (L.) Kunth; P. tetraphylla (G. Forst.) Hook. & Arn.; P. urocarpa Fisch. & C. A. Mey.

ABSTRACT Peperomia Ruiz & Pav. is the second largest genus of Piperaceae with about 1,600 to 1,700 species in the world, with greater diversity in the Neotropics and with great representation in Brazil. The objective of the work was to identify as Peperomia Ruiz & Pav. species present in the Reserva Biológica do Tinguá, carrying out taxonomic treatment and comments. The REBIO of Tinguá is a Federal Conservation Unit of Integral Protection, located in the State of Rio de Janeiro and inserted in the Atlantic Forest biome. There have been found 14 taxa in REBIO of Tinguá: Peperomia alata Ruiz & Pav.; P. catharinae Miq.; P. corcovadensis Gardner; P. dichotoma Regel; P. glabella (Sw.) A. Dietr. var. glabella; P. glabella var. nervulosa (C. DC.) Yunck.; P. glabella var. nigropunctata (Miq.) Dahlst.; P. glazioui C. DC.; P. nitida Dahlst.; P. obtusifolia (L.) A. Dietr.; P. quadrifolia (L.) Kunth; P. rotundifolia (L.) Kunth; P. tetraphylla (G. Forst.) Hook. & Arn.; P. urocarpa Fisch. & C. A. Mey.

https://doi.org/10.1590/2236-8906-38/2020 1 descargas

Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans
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Kehdy, Fernanda S.G.

; Pita-Oliveira, Murilo

; Scudeler, Mariana M.

; Torres-Loureiro, Sabrina

; Zolini, Camila

; Moreira, Rennan

; Michelin, Lucas A.

; Alvim, Isabela

; Silva-Carvalho, Carolina

; Furlan, Vinicius C.

; Aquino, Marla M.

; Santolalla, Meddly L.

; Borda, Victor

; Soares-Souza, Giordano B.

; Jaramillo-Valverde, Luis

; Vasquez-Dominguez, Andres

; Neira, Cesar Sanchez

; Aguiar, Renato S.

; Verdugo, Ricardo A.

; O`Connor, Timothy D.

; Guio, Heinner

; Tarazona-Santos, Eduardo

; Leal, Thiago P.

; Rodrigues-Soares, Fernanda

Genetics and Molecular Biology

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2021, Volumen 44 Nº 1 elocation e20200484

Resumen: En | Texto: En | PDF: En

Abstract For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of population genetics and of sequencing data in the design of genetic association studies in different human populations: the high linkage disequilibrium (LD) between rs2070788 and rs383510 is Asian-specific. Leveraging on a combination of genotyping and sequencing data for Native Americans (neglected in genetic studies), we show that while their frequencies of the Asian tag-SNP rs2070788 is, surprisingly, the highest worldwide, it is not in LD with the eQTL rs383510, that therefore, should be directly genotyped in genetic association studies of SARS in populations with Native American ancestry.

https://doi.org/10.1590/1678-4685-gmb-2020-0484 193 descargas

Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
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Fink, Thais T.

; Marques, Heloisa H.S.

; Gualano, Bruno

; Lindoso, Livia

; Bain, Vera

; Astley, Camilla

; Martins, Fernanda

; Matheus, Denise

; Matsuo, Olivia M.

; Suguita, Priscila

; Trindade, Vitor

; Paula, Camila S.Y.

; Farhat, Sylvia C.L.

; Palmeira, Patricia

; Leal, Gabriela N.

; Suzuki, Lisa

; Odone Filho, Vicente

; Carneiro-Sampaio, Magda

; Duarte, Alberto José S.

; Antonangelo, Leila

; Batisttella, Linamara R.

; Polanczyk, Guilherme V.

; Pereira, Rosa Maria R.

; Carvalho, Carlos Roberto R.

; Buchpiguel, Carlos A.

; Latronico, Ana Claudia

; Seelaender, Marilia

; Silva, Clovis Artur

; Pereira, Maria Fernanda B.

; Sallum, Adriana M. E.

; Brentani, Alexandra V. M.

; Neto, Álvaro José S.

; Ihara, Amanda

; Santos, Andrea R.

; Canton, Ana Pinheiro M.

; Watanabe, Andreia

; Santos, Angélica C. dos

; Pastorino, Antonio C.

; Franco, Bernadette D. G. M.

; Caruzo, Bruna

; Ceneviva, Carina

; Martins, Carolina C. M. F.

; Prado, Danilo

; Abellan, Deipara M.

; Benatti, Fabiana B.

; Smaria, Fabiana

; Gonçalves, Fernanda T.

; Penteado, Fernando D.

; Castro, Gabriela S. F. de

; Gonçalves, Guilherme S.

; Roschel, Hamilton

; Disi, Ilana R.

; Marques, Isabela G.

; Castro, Inar A.

; Buscatti, Izabel M.

; Faiad, Jaline Z.

; Fiamoncini, Jarlei

; Rodrigues, Joaquim C.

; Carneiro, Jorge D. A.

; Paz, Jose A.

; Ferreira, Juliana C.

; Ferreira, Juliana C. O.

; Silva, Katia R.

; Bastos, Karina L. M.

; Kozu, Katia

; Cristofani, Lilian M.

; Souza, Lucas V. B.

; Campos, Lucia M. A.

; Silva Filho, Luiz Vicente R. F.

; Sapienza, Marcelo T.

; Lima, Marcos S.

; Garanito, Marlene P.

; Santos, Márcia F. A.

; Dorna, Mayra B.

; Aikawa, Nadia E.

; Litvinov, Nadia

; Sakita, Neusa K.

; Gaiolla, Paula V. V.

; Pasqualucci, Paula

; Toma, Ricardo K.

; Correa-Silva, Simone

; Sieczkowska, Sofia M.

; Imamura, Marta

; Forsait, Silvana

; Santos, Vera A.

; Zheng, Yingying

Clinics

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2021, Volumen 76 elocation e3511

Resumen: En | Texto: En | PDF: En

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.

https://doi.org/10.6061/clinics/2021/e3511

Morphometric Analysis and Pattern of Protein and Gene Expression of Apoptosis in Focal Cerebral Ischemia in Rats and the Neuroprotetive Action of Hypothermia and Ketoprofen
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Tirapelli, Daniela P. C

; Cirino, Mucio Luiz de Assis

; Carvalho, Camila A. Melo de

; Novais, Paulo Cezar

; Figueredo, Rafael Zimak

; Porsani, Lucas Barbosa

; Gula, Isabella Stracieri

; Rodrigues, Andressa Romualdo

; Silva, Jairo Pinheiro da

; Pereira, Adriana Lis

; Lizarte Neto, Fermino Sanches

; Schimming, Bruno Cesar

; Tazima, Maria de Fátima Galli Sorita

; Fazan, Valéria de Paula Sassoli

; Carlotti-Jr, Carlos Gilberto

; Tirapelli, Luis Fernando

; Colli, Benedicto Oscar

International Journal of Morphology

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Jun 2020, Volumen 38 Nº 3 Paginas 523 - 529

Resumen: En Es | Texto: En Es | PDF: En | PDF: Es

SUMMARY: This study aimed to investigate the morphometric and the pattern of protein and gene expression related to the extrinsic apoptotic pathway in experimental focal cerebral ischemia and the hole of neuroprotection with hypothermia and ketoprofen. For this analysis, 120 rats were randomly divided into 3 groups (20 animals each): control - no surgery (20 animals); sham - simulation of surgery (20 animals); ischemic - focal ischemia for 1 hour, without reperfusion (80 animals) and divided into four subgroups with 20 animals each: ischemic + intraischemic hypothermia; ischemic + previous intravenous ketoprofen, and ischemic + hypothermia and ketoprofen. The infarct volume was measured using morphometric analysis of infarct areas defined by triphenyl tetrazolium chloride and the patterns of expression of the apoptosis genes (Fas, c-Flip, caspase-8 and caspase-3) and the apoptosis protein caspase-3 were evaluated by quantitative real-time PCR and immunohistochemistry, respectively. Hypo expression of genes of extrinsic pathway of apoptosis was observed: Fas receptor, c-Flip and caspase-8 in the ischemics areas. Increases in the gene and protein caspase-3 in the ischemic areas were also observed, and these increases were reduced by hypothermia and ketoprofen, also noted in the morphometric study. The caspases-3 increase suggests that this gene plays an important role in apoptosis, probably culminating in cell death and that the neuroprotective effect of hypothermia and ketoprofen is involved.

RESUMEN: Este estudio tuvo como objetivo investigar la morfometría y el patrón de expresión de proteínas y genes relacionados con la vía apoptótica extrínseca en la isquemia cerebral focal experimental y el agujero de neuroprotección con hipotermia y ketoprofeno. Se dividieron aleatoriamente 120 ratas en 3 grupos (20 animales cada uno): control - sin cirugía (20 animales); simulación - simulación de cirugía (20 animales); isquemia isquemia focal durante 1 hora, sin reperfusión (80 animales) y dividida en cuatro subgrupos con 20 animales cada uno: isquemia + hipotermia intraisquémica; isquemia + ketoprofeno intravenoso previo, e isquemia + hipotermia y ketoprofeno. El volumen del infarto se midió utilizando un análisis morfométrico de áreas de infarto definidas por cloruro de trifenil tetrazolio y los patrones de expresión de los genes de apoptosis (Fas, c-Flip, caspase-8 y caspase-3) y la proteína de apoptosis caspase-3 fueron evaluados por PCR cuantitativa en tiempo real e inmunohistoquímica, respectivamente. Se observó hipoexpresión de genes de la vía extrínseca de la apoptosis: receptor Fas, c-Flip y caspasa-8 en las áreas isquémicas. También se observaron aumentos en el gen y la proteína caspasa-3 en las áreas isquémicas y estos aumentos se redujeron por hipotermia y ketoprofeno, también observado por estudio morfométrico. El aumento de caspasas-3 sugiere que este gen tiene un papel importante en la apoptosis, y probable causa de muerte celular, involucrando el efecto neuroprotector de la hipotermia y el ketoprofeno.

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Personality differences and COVID-19: are extroversion and conscientiousness personality traits associated with engagement with containment measures?
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Carvalho, Lucas de F.

; Pianowski, Giselle

; Gonçalves, André P.

Trends in Psychiatry and Psychotherapy

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Jun 2020, Volumen 42 Nº 2 Paginas 179 - 184

Resumen: En | Texto: En | PDF: En

Abstract Introduction In December 2019, an outbreak of the novel coronavirus, the coronavirus disease 2019 (COVID-19) probably occurred in Wuhan, China. By March 2020, the World Health Organization (WHO) had declared a pandemic. Containment measures such as social distancing and hand hygiene were recommended. In this study, we start from the hypothesis that engaging with containment measures in a pandemic situation should be more comfortable for some people than for other people. Thus, individual differences should be associated with engagement with containment measures. Objective To investigate to what extent two personality traits, extroversion and conscientiousness, are associated with engagement with two containment measures (social distancing and handwashing). Methods The sample consisted of 715 Brazilian adults aged 18-78 years, who answered the Big Five Inventory 2 Short (BFI-2-S) and factors from the Dimensional Clinical Personality Inventory 2 (IDCP-2). Results Higher scores for extroversion were associated with lower means for social distancing (p < 0.001) and higher scores for conscientiousness were associated with higher means for social distancing and handwashing (p < 0.05). Conclusion The findings indicate the importance of acknowledging extroversion and conscientiousness traits as relevant to people’s engagement with the measures recommended for COVID-19 containment.

https://doi.org/10.1590/2237-6089-2020-0029 6532 descargas

10.

Increased platelet distribution width and reduced IL-2 and IL-12 are associated with thrombocytopenia in Plasmodium vivax malaria
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Costa, Allyson Guimarães

; Chaves, Yury Oliveira

; Teixeira-Carvalho, Andréa

; Ramasawmy, Rajendranath

; Antonelli, Lis Ribeiro Valle

; Barbosa, Lucas

; Balieiro, Antonio

; Monteiro, Wuelton Marcelo

; Mourão, Maria Paula

; Lacerda, Marcus Vinicius Guimarães

; Martins-Filho, Olindo Assis

; Costa, Fabio Trindade Maranhão

; Malheiro, Adriana

; Nogueira, Paulo Afonso

Memórias do Instituto Oswaldo Cruz

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2020, Volumen 115 elocation e200080

Resumen: En | Texto: En | PDF: En

BACKGROUND Thrombocytopenia in malaria involves platelet destruction and consumption; however, the cellular response underlying this phenomenon has still not been elucidated. OBJECTIVE To find associations between platelet indices and unbalanced Th1/Th2/Th17 cytokines as a response to thrombocytopenia in Plasmodium vivax infected (Pv-MAL) patients. METHODS Platelet counts and quantification of Th1/Th2/Th17 cytokine levels were compared in 77 patients with uncomplicated P. vivax malaria and 37 healthy donors from the same area (endemic control group - ENCG). FINDINGS Thrombocytopenia was the main manifestation in 55 patients, but was not associated with parasitaemia. The Pv-MAL patients showed increases in the mean platelet volume (MPV), which may be consistent with larger or megaplatelets. Contrary to the findings regarding the endemic control group, MPV and platelet distribution width (PDW) did not show an inverse correlation, due the increase in the heterogeneity of platelet width. In addition, the Pv-MAL patients presented increased IL-1β and reduced IL-12p70 and IL-2 serum concentrations. Furthermore, the reduction of these cytokines was associated with PDW values. MAIN CONCLUSIONS Our data demonstrate that an increase in MPV and the association between reductions of IL-2 and IL-12 and PDW values may be an immune response to thrombocytopenia in uncomplicated P. vivax malaria.

https://doi.org/10.1590/0074-02760200080 790 descargas

11.

Development of a Scale to Measure Histrionic Traits According to the Hierarchical Taxonomy of Psychopathology
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Carvalho, Lucas de Francisco

; Sette, Catarina P.

; Ferrari, Bárbara Letícia

Trends in Psychology

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Sep 2019, Volumen 27 Nº 3 Paginas 707 - 720

Resumen: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo O objetivo deste estudo foi desenvolver uma versão do Inventário Dimensional Clínico da Personalidade 2 (IDCP-2) focada nos traços do transtorno da personalidade histriônico (TPH) de acordo com o modelo Hierarchical Taxonomy of Psychopathology (HiTOP), e verificar suas propriedades psicométricas. O método foi dividido em dois estágios. O primeiro para revisão do IDCP-2 de acordo com o HiTOP, focando nos traços típicos do TPH. O segundo objetivou verificar as propriedades da nova versão do IDCP-2 (i.e., IDCP-HPD) em uma amostra por conveniência (N=208), coletada via online. O IDCP-HPD foi aplicado junto a fatores do Personality Inventory for DSM-5 (PID-5) e Five-Factor Histrionic Inventory (FFHI). Dos 16 traços iniciais baseados no HiTOP, 8 foram selecionados para o TPH e 17 itens foram selecionados para os novos fatores. A solução com 4 fatores observada via exploratory structural equation modeling, as correlações com medidas externas e os efeitos das comparações entre grupos indicam a adequação psicométrica do IDCP-HPD. Os achados devem ser interpretados como evidências iniciais para o IDCP-HPD, indicando a praticidade do teste.

Abstract The aim of this study was to develop a version of the Dimensional Clinical Personality Inventory 2 (IDCP-2) focusing on the Histrionic Personality Disorder (HPD) traits according to the Hierarchical Taxonomy of Psychopathology (HiTOP) model, and to verify its psychometric properties. The method was divided into two stages. The first was related to the revision procedures of the IDCP-2 based on the HiTOP, focusing on the assessment of features typical of HPD. The second aimed to verify the psychometric properties of the new version of the IDCP-2 (i.e., IDCP-HPD) in a convenience sample (N=208), mainly composed of women, with data collection carried out online. The IDCP-HPD was administered with the Personality Inventory for DSM-5 (PID-5) and Five-Factor Histrionic Inventory (FFHI) factors. Of the 16 initial traits provided by the HiTOP, 8 were selected as relevant for the HPD and 17 items were selected to compose the new factors. The 4 factor solution found through exploratory structural equation modeling, the correlations with the external measures and the effects found in the between-group comparisons suggest the psychometric adequacy of the IDCP-HPD. The findings of this study should be interpreted as initial evidence for the IDCP-HPD, indicating the practicality of the test.

Resumen El objetivo de este estudio fue desarrollar una versión del Inventario Dimensional Clínico del Personalidad 2 (IDCP-2) que se centra en los rasgos del desorden histriónico de la personalidad (HPD) según el modelo de Taxonomía Jerárquica de la Psicopatología (HiTOP) y verificar sus propiedades psicométricas. El método se dividió en dos. Primero se relacionó con los procedimientos de revisión del IDCP-2 basados en el HiTOP, centrándose en la evaluación de las características típicas de HPD. El segundo verificou las propiedades psicométricas de la nueva versión del IDCP-2 (IDCP-HPD) en una muestra de conveniencia (N = 208), con la recopilación de datos en línea. El IDCP-HPD se administró con el Personality Inventory for DSM-5 (PID-5) y Five-Factor Histrionic Inventory (FFHI). De los 16 rasgos iniciales del HiTOP, 8 fueron seleccionados para el HPD y 17 ítens fueron seleccionados para componer los nuevos factores. La solución de 4 factores encontrada en modelo exploratorio de ecuaciones estructurales, las correlaciones y los efectos en las comparaciones entre grupos sugieren la adecuación psicométrica del IDCP-HPD. Los hallazgos de este estudio deben interpretarse como evidencia inicial para el IDCP-HPD, que indica la practicidad de la prueba.

https://doi.org/10.9788/tp2019.3-08 1940 descargas

12.

Serum amyloid A and muscle activity biomarkers in horses submitted to equestrian show jumping
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Carvalho Filho, Wilson P.

; Fonseca, Leandro A.

; Girardi, Fabricia M.

; Bento, Lucas D.

; Souto, Pollyanna C.

; Orozco, Andres M.O.

Pesquisa Veterinária Brasileira

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Ago 2019, Volumen 39 Nº 8 Paginas 668 - 671

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste estudo foi avaliar a amilóide sérica A (SAA) e biomarcadores de atividade muscular de equinos submetidos a atividade de salto, ou hipismo clássico. Para tanto, foram avaliadas as variáveis SAA, glicose, lactato e os biomarcadores creatina quinase (CK) e aspartatoaminotransferase (AST) em 10 equinos submetidos ao exercício de saltos em torneio para iniciantes. As avaliações ocorreram antes do exercício (T0), imediatamente após (T1), 30 minutos (T2), 60 minutos (T3) e 24 horas após o término (T4). Os dados foram avaliados utilizando análise de variância para medidas repetidas. O software estatístico SAEG 9.1 foi utilizado para verificar o nível de significância entre os momentos para P<0,05. A glicose diferenciou-se entre os momentos T0 (97.7±13.3mg/dL) e T1 (79.7±14.1mg/dL). O lactado apresentou elevação comparada com o momento T1(15.3±6.1mmol/L) e os demais T0 (3.8±0.8mmol/L), T2 (6.5±3.9mmol/L), T3 (5.3±2.2mmol/L) e T4 (5.1±1.6mmol/L). A CK mostrou diferença significativa entre T0 (82.8±51.2U/L) e T1 (140.1±58.5U/L) e entre T4 (74.4±43.1U/L) com T1 (140.1±58.5U/L). A AST não apresentou diferença entre os momentos. A atividade de hipismo clássico com obstáculos de um metro não induziu alterações na proteína SAA entre os momentos.

ABSTRACT: The aim of this study was to evaluate the serum amyloid A (SAA) and biomarkers of muscle activity of horses submitted to show jumping activity. To do this, the variables SAA, glucose, lactate and the biomarkers creatine kinase (CK) and aspartate amino transferase (AST) were evaluated in 10 horses submitted to the show jumping exercise in a tournament for beginners. The evaluations occurred before exercise (T0), immediately after (T1), 30 minutes (T2), 60 minutes (T3) and 24 hours after the end (T4). Data were evaluated using analysis of variance for repeated measures. The statistical software SAEG 9.1 was used to verify the level of significance between the moments for P<0.05. Glucose presented a difference between the moments T0 (97.7±13.3mg/dL) and T1 (79.7±14.1mg/dL). Lactate presented elevation in T1 (15.3±6.1mmol/L) compared to the others T0 (3.8±0.8mmol/L), T2 (6.5±3.9mmol/L), T3 (5.3±2.2mmol/L) and T4 (5.1±1.6mmol/L). The CK showed a significant difference between T0 (82.8±51.2U/L) and T1 (140.1±58.5U/L) and between T4 (74.4±43.1U/L) with T1 (140.1±58.5U/L). The AST presented no difference between moments. The show jumping activity with one-meter obstacles did not induce changes in the SAA protein between the moments.

https://doi.org/10.1590/1678-5150-pvb-6218 901 descargas

13.

Molecular characteristics of methicillin-resistant Staphylococcus aureus isolates from hospital and community environments in northeastern Brazil
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Carvalho, Suzi P. de

; Almeida, Jéssica B. de

; Andrade, Yasmin M.F.S.

; Silva, Lucas S.C. da

; Chamon, Raiane C.

; Santos, Kátia R.N. dos

; Marques, Lucas M.

Brazilian Journal of Infectious Diseases

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Mar 2019, Volumen 23 Nº 2 Paginas 134 - 138

Resumen: En | Texto: En | PDF: En

ABSTRACT This study characterized 30 MRSA isolates from intensive care unit (ICU) environment and equipment surfaces and healthy children. The SCCmec types I, IVa and V were detected in HA-MRSA isolates while CA-MRSA showed the SCCmec type IVa and V. Most isolates were classified as agr group II. All isolates presented the sei gene, and only HA-MRSA were positive for etb e tst genes. Three genotypes were related to Pediatric (ST5/SCCmecIV) and Berlin (ST45/SCCmecIV) clones. The present study showed molecular similarity between CA- and HA-MRSA isolates in hospital and community settings in a Brazilian region.

https://doi.org/10.1016/j.bjid.2019.04.005 674 descargas

14.

Consortium of five fungal isolates conditioning root growth and arbuscular mycorrhiza in soybean, corn, and sugarcane
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FARIAS, CHRISTYAN P.

; CARVALHO, RAFAEL C. DE

; RESENDE, FELIPE M.L.

; AZEVEDO, LUCAS C.B.

Anais da Academia Brasileira de Ciências

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Dic 2018, Volumen 90 Nº 4 Paginas 3649 - 3660

Resumen: En | Texto: En | PDF: En

Abstract Plant growth and arbuscular mycorrhizal colonization were studied in sugarcane, corn and soybean by applying five plant growth promoting fungi: Beauveria bassiana, Metarhizium anisopliae, Pochonia chlamydosporia, Purpureocillium lilacinum, and Trichoderma asperella. Sugarcane, corn and soybean were grown in pots under two treatments: (1) inoculation with the fungal consortium and (2) control without inoculation. In the inoculated treatment, fungal spore suspension were applied to the seeds and shoots were sprayed every 28 days. Means were analyzed by analysis of variance and Tukey’s test at 5% probability level. The experiment was arranged in a completely randomized design, with six replications. Fungi consortium mediate root growth in soybean and corn, and arbuscular mycorrhizal colonization in soybean and sugarcane. These findings are probably caused by the fungi producing phytohormones and inducing the plants to synthesize phytohormones: auxins for root growth; and jasmonic, abscisic, and salicylic acids with a role in the regulation of mycorrhizal colonization. These effects are important when seeking conservation strategies in agriculture and livestock production, since Fungi consortium can better mediate soil resource acquisition, promoting greater absorption of nutrients and water.

https://doi.org/10.1590/0001-3765201820180161 1791 descargas

15.

MANEJO DE COLHEITA E ADUBAÇÃO FOSFATADA NA CULTURA DA ERVA-MATE (Ilex paraguariensis) EM FASE DE PRODUÇÃO
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Santin, Delmar

; Benedetti, Eliziane Luiza

; Barros, Nairam Félix de

; Fontes, Lucas Leandro

; Almeida, Igor Carvalho de

; Neves, Júlio César Lima

; Wendling, Ivar

Ciência Florestal

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Sep 2017, Volumen 27 Nº 3 Paginas 783 - 797

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO As sucessivas colheitas na base de folhas (FO) e galhos finos (GF), sem a necessária reposição nutricional, têm proporcionado quedas na produtividade brasileira de erva-mate nos últimos 20 anos. Neste sentido, o objetivo do trabalho foi avaliar a influência do intervalo de colheita e da adubação fosfatada na disponibilidade de fósforo (P) no solo, na produtividade e no estado nutricional da erva-mate. O experimento foi conduzido em São Mateus do Sul - PR, em Latossolo Vermelho-Escuro álico, onde se avaliaram doses de 0, 20, 40, 80, 160 e 320 kg ha-1 de P2 O5 para colheitas com intervalos de 12, 18 e 24 meses em erval com sete anos. A colheita consistiu na remoção de aproximadamente 95 % da copa formada após a colheita anterior. A massa verde colhida foi determinada individualmente para os componentes FO, GF e galho grosso (GG), sendo FO + GF correspondente à erva-mate comercial (ECOM). Dos componentes da planta, também se avaliou a relação entre massa verde/seca (MV/MS) e teor de P na FO, GF e GG. No momento da colheita coletaram-se amostras de solo nas profundidades de 0-10, 10-20 e 20-40 cm, nas quais se avaliou a disponibilidade de P. A adubação fosfatada elevou a disponibilidade de P no solo nas primeiras camadas e a cultura respondeu positivamente ao nutriente com aumento da produtividade em todos os componentes avaliados. Altas produtividades de ECOM, independentemente do intervalo de colheita, dependem de disponibilidade de P no solo em nível alto na camada de 0-10 cm. Colheitas com intervalos de tempo maiores resultaram em maiores produtividades de ECOM, mas para maximizar a produtividade, necessita-se de doses mais elevadas de fertilizantes. Intervalos de 12 meses são insuficientes para que a planta se recupere do impacto da colheita, mesmo quando a planta está bem nutrida em fósforo.

ABSTRACT Successive harvesting of leaves (FO) and thin branches (GF), with no nutrient reposition by fertilization, have been resulting in continuous decrease in Brazilian productivity of mate in the last 20 years. So, the objective of this work was to evaluate the influence of harvest interval and phosphate nutrition on the availability of phosphorus (P) in the soil, on the productivity, as well as on the nutritional status of mate plants. The experiment was conducted in São Mateus do Sul/PR, in an Oxisol, where doses of 0, 20, 40, 80, 160 and 320 kg ha-1 of P2 O5 were evaluated for harvest intervals of 12, 18 and 24-months in a seven-year-old mate plantation. Soil P availability, at 0-10, 10-20 and 20-40 cm depth, was assessed. Harvest consisted on removal of approximately 95 % of the tree canopy formed since the previous harvest. Harvested green material was individually determined for FO, GF and thick branches (GG), where FO + GF corresponded to the commercial mate (ECOM). The relationship between green/dry mass (MV/MS) was also evaluated for all plant components, as well as the content of P in FO, GF and GG. Phosphate fertilization increased the availability of P in the upper soil layer and the plant responded positively to P application by increasing the dry mass of all the assessed components. Harvests with longer intervals resulted in greater productivity of ECOM, but for maximizing productivity, high doses of fertilizers are needed. Twelve month intervals are insufficient to allow the plant to recover from the harvest impact, even if well-nourished in phosphorus.

https://doi.org/10.5902/1980509828629 1534 descargas

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