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Abstract Healthcare workers present an increased risk of contagion for the SARS-CoV-2 virus due to their labor exposure. Here, we describe the clinical, laboratory, and immunological characteristics of healthcare workers, before vaccine application, exposed to SARS-CoV-2-infected patients. We collected sociodemographic, clinical, and laboratory information from 50 professionals who worked during the COVID-19 pandemic at the Clinical Hospital of the Northwest in Brazil. The results showed that most workers are women, over 50 years old, and worked as nursing technicians. Approximately 56% of workers were positive for a previous infection by RT-PCR and/or anti-SARS-CoV-2-immunoglobulin tests. Increased levels of hematocrit, neutrophils, NK lymphocytes, and fibrinogen, were found in positive healthcare workers, suggesting a light inflammatory status. The immunological findings showed an increase in IL-17 production and a Th2/Th17/Th22 profile followed by high serology for anti-SARS-CoV-2 IgM and IgG. Those data reveal the importance of studies with healthcare workers to investigate if the continuous exposition to the virus may result in chronic activation of the immune system and/or pulmonary inflammation in this target group.

https://doi.org/10.1590/0001-3765202320220502

Precision non-implantable neuromodulation therapies: a perspective for the depressed brain
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Borrione, Lucas

; Bellini, Helena

; Razza, Lais Boralli

; Avila, Ana G.

; Baeken, Chris

; Brem, Anna-Katharine

; Busatto, Geraldo

; Carvalho, Andre F.

; Chekroud, Adam

; Daskalakis, Zafiris J.

; Deng, Zhi-De

; Downar, Jonathan

; Gattaz, Wagner

; Loo, Colleen

; Lotufo, Paulo A.

; Martin, Maria da Graça M.

; McClintock, Shawn M.

; O’Shea, Jacinta

; Padberg, Frank

; Passos, Ives C.

; Salum, Giovanni A.

; Vanderhasselt, Marie-Anne

; Fraguas, Renerio

; Benseñor, Isabela

; Valiengo, Leandro

; Brunoni, Andre R.

Brazilian Journal of Psychiatry

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Ago 2020, Volumen 42 Nº 4 Paginas 403 - 419

Resumen: En | Texto: En | PDF: En

Current first-line treatments for major depressive disorder (MDD) include pharmacotherapy and cognitive-behavioral therapy. However, one-third of depressed patients do not achieve remission after multiple medication trials, and psychotherapy can be costly and time-consuming. Although non-implantable neuromodulation (NIN) techniques such as transcranial magnetic stimulation, transcranial direct current stimulation, electroconvulsive therapy, and magnetic seizure therapy are gaining momentum for treating MDD, the efficacy of non-convulsive techniques is still modest, whereas use of convulsive modalities is limited by their cognitive side effects. In this context, we propose that NIN techniques could benefit from a precision-oriented approach. In this review, we discuss the challenges and opportunities in implementing such a framework, focusing on enhancing NIN effects via a combination of individualized cognitive interventions, using closed-loop approaches, identifying multimodal biomarkers, using computer electric field modeling to guide targeting and quantify dosage, and using machine learning algorithms to integrate data collected at multiple biological levels and identify clinical responders. Though promising, this framework is currently limited, as previous studies have employed small samples and did not sufficiently explore pathophysiological mechanisms associated with NIN response and side effects. Moreover, cost-effectiveness analyses have not been performed. Nevertheless, further advancements in clinical trials of NIN could shift the field toward a more “precision-oriented” practice.

https://doi.org/10.1590/1516-4446-2019-0741 1546 descargas

Infection by Streptococcus pneumoniae in children with or without radiologically confirmed pneumonia
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Andrade, Dafne C.

; Borges, Igor C.

; Vilas-Boas, Ana Luísa

; Fontoura, Maria S.H.

; Araújo-Neto, César A.

; Andrade, Sandra C.

; Brim, Rosa V.

; Meinke, Andreas

; Barral, Aldina

; Ruuskanen, Olli

; Käyhty, Helena

; Nascimento-Carvalho, Cristiana M.

Jornal de Pediatria

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Feb 2018, Volumen 94 Nº 1 Paginas 23 - 30

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Avaliar o papel do raios X de tórax na identificação de casos de pneumonia adquirida na comunidade (PAC) causada por agentes bacterianos. Métodos: A frequência de infecção por Streptococcus pneumoniae, Haemophilus influenzae e Moraxella catarrhalis em crianças com PAC não hospitalizadas foi comparada com a presença de confirmação radiológica da pneumonia (n = 249 crianças com pneumonia radiologicamente confirmada e 366 crianças com raios X de tórax normal). Infecção por S. pneumoniae foi diagnosticada com base na resposta sorológica a pelo menos uma dentre oito proteínas pneumocócicas investigadas (aumento ≥ 2 vezes nos níveis de IgG em relação a Ply, CbpA, PspA1 e 2, PhtD, StkP-C e PcsB-N ou aumento≥ 1,5 vez em relação aPcpA). Infecção por H. influenzae e M. catarrhalis foi definida por aumento ≥ 2 vezes nos níveis de IgG específica a antígenos de cada agente. Resultados: Crianças com pneumonia radiologicamente confirmada apresentaram maior taxa de infecção pelo pneumococo. Além disso, a presença de infecção pneumocócica foi um fator preditor de pneumonia radiologicamente confirmada, o que aumenta sua chance de detecção em 2,8 vezes (IC 95%: 1,8-4,3). O valor preditivo negativo do raios X normal para a infecção por S. pneumoniae foi 86,3% (IC95%: 82,4%-89,7%). Não houve diferença nas frequências de infecção por H. influenzae e M. catarrhalis entre crianças com PAC com ou sem confirmação radiológica. Conclusão: Crianças com diagnóstico clínico de PAC submetidas a um raios X de tórax que apresentam confirmação radiológica têm maior taxa de infecção por S. pneumoniae comparadas com as crianças com raios X normal.

Abstract Objective: Community-acquired pneumonia is an important cause of morbidity in childhood, but the detection of its causative agent remains a diagnostic challenge. The authors aimed to evaluate the role of the chest radiograph to identify cases of community-aquired pneumonia caused by typical bacteria. Methods: The frequency of infection by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis was compared in non-hospitalized children with clinical diagnosis of community acquired pneumonia aged 2-59 months with or without radiological confirmation (n = 249 and 366, respectively). Infection by S. pneumoniae was diagnosed by the detection of a serological response against at least one of eight pneumococcal proteins (defined as an increase ≥2-fold in the IgG levels against Ply, CbpA, PspA1 and PspA2, PhtD, StkP-C, and PcsB-N, or an increase ≥1.5-fold against PcpA). Infection by H. influenzae and M. catarrhalis was defined as an increase ≥2-fold on the levels of microbe-specific IgG. Results: Children with radiologically confirmed pneumonia had higher rates of infection by S. pneumoniae. The presence of pneumococcal infection increased the odds of having radiologically confirmed pneumonia by 2.8 times (95% CI: 1.8-4.3). The negative predictive value of the normal chest radiograph for infection by S. pneumoniae was 86.3% (95% CI: 82.4-89.7%). There was no difference on the rates of infection by H. influenzae and M. catarrhalis between children with community-acquired pneumonia with and without radiological confirmation. Conclusions: Among children with clinical diagnosis of community-acquired pneumonia submitted to chest radiograph, those with radiologically confirmed pneumonia present a higher rate of infection by S. pneumoniae when compared with those with a normal chest radiograph.

https://doi.org/10.1016/j.jped.2017.03.004 2665 descargas

Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components
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Carvalho, Flávio A.

; Uchina, Helena S.

; Borges, Felipe A.

; Oyafuso, Márcia H.

; Herculano, Rondinelli D.

; Gremião, Maria P.D.

; Santos, André G.

Revista Brasileira de Farmacognosia

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Ene 2018, Volumen 28 Nº 1 Paginas 102 - 110

Resumen: En | Texto: En | PDF: En

ABSTRACT Natural latex from Hevea brasiliensis (Wild. ex A.Juss) Müll.Arg., Euphorbiaceae, showed angiogenic action and Casearia sylvestris Sw., Salicaceae, leaf derivatives presented anti-inflammatory and wound healing activities. Therefore, an association of these effects was interesting for wound healing applications. The aims of this study were the development of membranes of natural latex incorporated with C. sylvestris leaf derivatives (ethanolic extract, diterpene concentrated fraction and casearin J), their chemical and physical characterization, and the evaluation of in vitro skin permeation and retention of C. sylvestris bioactive secondary metabolites (diterpenes and phenolic compounds). The membranes were developed mixing hydroethanolic solutions of C. sylvestris derivatives with latex and drying them in a desiccator. They were characterized by infrared spectroscopy, scanning electron microscopy, water vapor permeability and mechanical resistance assays, demonstrating that all membranes were permeable, resistant and homogeneous in surfaces. The permeation and retention assays demonstrated dermal penetration of phenolic compounds for ethanolic extract membrane and of casearin-like clerodane diterpenes for all membranes, indicating that these membranes have great potential for therapeutical application as a topical system for C. sylvestris components releasing.

https://doi.org/10.1016/j.bjp.2017.10.007 1176 descargas

Comparison of four molecular approaches to identify Candida parapsilosis complex species
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Barbedo, Leonardo Silva

; Figueiredo-Carvalho, Maria Helena Galdino

; Muniz, Mauro de Medeiros

; Zancopé-Oliveira, Rosely Maria

Memórias do Instituto Oswaldo Cruz

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Mar 2017, Volumen 112 Nº 3 Paginas 214 - 219

Resumen: En | Texto: En | PDF: En

Since the description of Candida orthopsilosis and C. metapsilosis in 2005, several methods have been proposed to identify and differentiate these species from C. parapsilosis sensu stricto. Species-specific uniplex polymerase chain reaction (PCR) was performed and compared with sequencing of the D1/D2 region of the LSU 28S rDNA gene, microsatellite typing of C. parapsilosis sensu stricto, and PCR-restriction fragment length polymorphism patterns in the ITS1-5.8S-ITS2 region of the rDNA gene. There was agreement between results of testing of 98 clinical isolates with the four PCR-based methods, with 59 isolates identified as C. parapsilosis sensu stricto, 37 as C. orthopsilosis, and two as C. metapsilosis.

https://doi.org/10.1590/0074-02760160412 1271 descargas

Thyroid abnormalities in term infants with fungal sepsis
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Silva, Maria Helena Baptista Nunes da

; Araujo, Maria Cristina Korbage de

; Diniz, Edna Maria de Albuquerque

; Ceccon, Maria Esther Jurfest Rivero

; Carvalho, Werther Brunow de

Revista da Associação Médica Brasileira

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Sep 2016, Volumen 62 Nº 6 Paginas 561 - 567

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: descrever as alterações tireoidianas em recém-nascidos de termo (RNT) que apresentaram sepse fúngica durante internação na UTI neonatal. Método: foram incluídos seis RNT que, durante as manifestações clínicas e laboratoriais de sepse, com culturas positivas para fungo, apresentaram alterações dos hormônios tireoidianos, denominadas síndrome do T3 baixo e síndrome do T3 e T4 baixo. Foram excluídos RNT que apresentaram alteração hormonal por doença, como RNT filhos de mães com doença tireoidiana, asfixia perinatal e cirurgias de grande porte. Resultados: dos seis RNT com sepse fúngica, cinco apresentavam cultura positiva para Candida albicans e um para C. tropicalis. A síndrome do T3 baixo foi observada em duas crianças (50%) e a do T3 e T4 baixo em dois RN (100%). As quatro crianças evoluíram com choque séptico. Conclusão: a sepse fúngica é cada vez mais frequente nos recém-nascidos internados em UTI neonatal. A insuficiência tireoidiana pode vir a ser marcadora de gravidade da doença, e a suplementação hormonal pode ser necessária.

Summary Objective: To describe thyroid alterations in term newborns (TNB) with fungal sepsis during NICU hospitalization. Method: The study included six TNB that during the clinical and laboratory manifestations of sepsis with positive cultures for fungus showed changes in thyroid hormones, called low T3 syndrome and low T3-T4 syndrome. TNB that could present hormonal changes caused by disease as those born to mothers with thyroid disease, or who had perinatal asphyxia and major surgeries were excluded. Results: Of six TNB with fungal sepsis, five had positive culture for Candida albicans and one had positive culture for Candida tropicalis. Low T3 syndrome was observed in two TNB (50%), while T3-T4 syndrome was observed in other two (100%). The four children progressed to septic shock. Conclusion: Fungal sepsis is becoming more common among newborns admitted to NICU. Thyroid insufficiency could be a marker of disease severity with possible need for hormone supplementation.

https://doi.org/10.1590/1806-9282.62.06.561 1424 descargas

The identification and differentiation of the Candida parapsilosis complex species by polymerase chain reaction-restriction fragment length polymorphism of the internal transcribed spacer region of the rDNA
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Barbedo, Leonardo Silva

; Figueiredo-Carvalho, Maria Helena Galdino

; Muniz, Mauro de Medeiros

; Zancopé-Oliveira, Rosely Maria

Memórias do Instituto Oswaldo Cruz

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Abr 2016, Volumen 111 Nº 4 Paginas 267 - 270

Resumen: En | Texto: En | PDF: En

Currently, it is accepted that there are three species that were formerly grouped under Candida parapsilosis: C. para- psilosis sensu stricto, Candida orthopsilosis, andCandida metapsilosis. In fact, the antifungal susceptibility profiles and distinct virulence attributes demonstrate the differences in these nosocomial pathogens. An accurate, fast, and economical identification of fungal species has been the main goal in mycology. In the present study, we searched sequences that were available in the GenBank database in order to identify the complete sequence for the internal transcribed spacer (ITS)1-5.8S-ITS2 region, which is comprised of the forward and reverse primers ITS1 and ITS4. Subsequently, an in silico polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to differentiate the C. parapsilosis complex species. Ninety-eight clinical isolates from patients with fungaemia were submitted for analysis, where 59 isolates were identified as C. parapsilosis sensu stricto, 37 were identified as C. orthopsilosis, and two were identified as C. metapsilosis. PCR-RFLP quickly and accurately identified C. parapsilosis complex species, making this method an alternative and routine identification system for use in clinical mycology laboratories.

https://doi.org/10.1590/0074-02760150466 2150 descargas

Emergence of polymyxin B-resistant Acinetobacter baumannii in hospitals in Rio de Janeiro
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Genteluci, Gabrielle L.

; Gomes, Daniela B. C.

; Souza, Maria José de

; Carvalho, Karyne R.

; Villas-Bôas, Maria Helena S.

Jornal Brasileiro de Patologia e Medicina Laboratorial

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Abr 2016, Volumen 52 Nº 2 Paginas 91 - 95

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Acinetobacter baumannii tem sido considerado um patógeno prevalente nos hospitais, gerando preocupação na comunidade médica por conta de seu extenso espectro de resistência aos antimicrobianos. Por ser um assunto que desperta muito interesse, tem sido cada vez mais estudado. Devido à emergência de bactérias Gram-negativas resistentes a múltiplas drogas (MDR), o uso de polimixinas foi reestabelecido. As polimixinas têm sido consideradas a única opção para o tratamento de infecções graves causadas por A. baumannii MDR. Objetivo: Investigar o perfil de suscetibilidade de A. baumannii à polimixina B. Material e método: Foram estudados 92 isolados clínicos provenientes de dois hospitais da rede pública do município do Rio de Janeiro por meio da técnica de microdiluição em caldo. Resultados: A maioria dos isolados foi resistente à polimixina B, 81,5% (n = 75), apresentando valores de concentração inibitória mínima (CIM) entre 4-64 mcg/ml. Conclusão: Esses resultados são preocupantes, já que atualmente as polimixinas têm sido consideradas a opção terapêutica mais eficaz contra isolados de A. baumannii MDR.

ABSTRACT Introduction: Acinetobacter baumannii has been considered a prevalent pathogen in hospitals, raising concern in the medical community due to its broad spectrum of antimicrobial resistance. Since it is a subject that arouses much interest, it has been increasingly studied. Due to the emergence of multidrug-resistant (MDR) Gram-negative bacteria, the use of polymyxins was reestablished. The polymyxins have been considered the only option for the treatment of severe infections caused by MDR A. baumannii. Objective: To investigate the susceptibility profile of A. baumannii to polymyxin B. Material and method: 92 clinical isolates from two public hospitals in the Rio de Janeiro city were studied using broth microdilution method. Results: Most of the isolates were resistant to polymyxin B, 81.5% (n = 75), and minimum inhibitory concentration (MIC) values ranged between 4-64 mcg/ml. Conclusion: These results are a concern since currently the polymyxins have been considered the most effective therapeutic option against MDR isolates of A. baumannii.

https://doi.org/10.5935/1676-2444.20160021 3752 descargas

First description of Candida nivariensis in Brazil: antifungal susceptibility profile and potential virulence attributes
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Figueiredo-Carvalho, Maria Helena Galdino

; Ramos, Livia de Souza

; Barbedo, Leonardo Silva

; Chaves, Alessandra Leal da Silva

; Muramoto, Ilda Akemi

; Santos, André Luis Souza dos

; Almeida-Paes, Rodrigo

; Zancopé-Oliveira, Rosely Maria

Memórias do Instituto Oswaldo Cruz

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Ene 2016, Volumen 111 Nº 1 Paginas 51 - 58

Resumen: En | Texto: En | PDF: En

This study evaluated the antifungal susceptibility profile and the production of potential virulence attributes in a clinical strain of Candida nivariensis for the first time in Brazil, as identified by sequencing the internal transcribed spacer (ITS)1-5.8S-ITS2 region and D1/D2 domains of the 28S of the rDNA. For comparative purposes, tests were also performed with reference strains. All strains presented low planktonic minimal inhibitory concentrations (PMICs) to amphotericin B (AMB), caspofungin (CAS), and voriconazole. However, our strain showed elevated planktonic MICs to posaconazole (POS) and itraconazole, in addition to fluconazole resistance. Adherence to inert surfaces was conducted onto glass and polystyrene. The biofilm formation and antifungal susceptibility on biofilm-growing cells were evaluated by crystal violet staining and a XTT reduction assay. All fungal strains were able to bind both tested surfaces and form biofilm, with a binding preference to polystyrene (p < 0.001). AMB promoted significant reductions (≈50%) in biofilm production by our C. nivariensis strain using both methodologies. This reduction was also observed for CAS and POS, but only in the XTT assay. All strains were excellent protease producers and moderate phytase producers, but lipases were not detected. This study reinforces the pathogenic potential of C. nivariensis and its possible resistance profile to the azolic drugs generally used for candidiasis management.

https://doi.org/10.1590/0074-02760150376 1676 descargas

10.

Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy
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Meneses, Guida

; Viana, Helena

; Santos, Maria C.

; Ferreira, Carina

; Calado, Joaquim

; Carvalho, Fernanda

; Remedio, Francisco

; Nolasco, Fernando

Portuguese Journal of Nephrology & Hypertension

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Mar 2015, Volumen 29 Nº 1 Paginas 44 - 47

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Anticorpos circulantes anti recetor da fosfolipase A2 (anti-RFLA2) têm sido descritos em 70% a 80% dos doentes com nefropatia membranosa idiopática (NMi) mas não em doentes com nefropatia membranosa secundária ou outras doenças glomerulares. O objetivo deste estudo foi avaliar a sensibilidade e especificidade do teste para anti-RFLA2 no diagnóstico de NMi. Foram utilizados os testes Elisa e imunofluorescência para deteção do Anti-RFLA2, IgG. Estes testes foram aplicados a 53 doentes com biópsia renal. Destes, 38 tiveram o diagnóstico histológico de nefropatia membranosa (NM), enquanto os restantes 15 doentes apresentaram outras doenças glomerulares. A NM foi classificada como idiopática em 33 doentes, após exclusão de causas secundárias. O Anti-RFLA2 foi positivo em 57,6% (n = 19) dos doentes com NMi. Todos os doentes com nefropatia membranosa secundária ou outras doenças glomerulares não apresentaram anti-RFLA2. A sensibilidade foi de 57,6% (IC 39,2-74,5) e a especificidade de 100% (IC 47,8-100), AUC 0,788; p < 0,0001 para a deteção de NMi. 71,4% (n = 10) dos 14 doentes com NMi que tiveram teste negativo para anti-RFLA2 estavam em remissão parcial ou completa. A deteção do anti-RFLA2 na população estudada apresentou uma especificidade de 100% para o diagnóstico de NMi. O sucesso do tratamento prévio terá contribuído para a baixa sensibilidade

Circulating anti-phospholipase A2 receptor antibodies (anti-PLA2R) have been described in 70% to 80% of the patients with idiopathic membranous nephropathy (iMN), but not in patients with secondary membranous nephropathy or other glomerular diseases. The goal of this study was to evaluate the sensitivity and specificity of the assay for anti-PLA2R in the diagnosis of iMN. Anti-PLA2R IgG, Elisa and immunofluorescence tests were used to detect circulating anti-PLA2R. These tests were applied in 53 patients who had a kidney biopsy. Of these, 38 had histological diagnosis of membranous nephropathy (MN) and the remaining had other glomerular diseases. The MN was classified as idiopathic in 33 patients after clinical exclusion of secondary causes. Anti-PLA2R were positive in 57.6% of the patients with iMN. All patients with secondary membranous nephropathy or other glomerular diseases did not show circulating anti-PLA2R. The sensitivity was 57.6% (CI 39.2-74.5) and specificity 100% (CI 47.8-100), AUC 0.788; p < 0.0001 for the detection of iMN. 71.4% of the iMN patients that tested negative for anti-PLA2R were in partial or complete remission. The detection of anti-PLA2R in the studied population had a specificity of 100% for the iMN diagnosis. Prior treatments seem to make the test negative and contribute to a lower sensitivity

2489 descargas

11.

II Diretriz de Ressonância Magnética e Tomografia Computadorizada Cardiovascular da Sociedade Brasileira de Cardiologia e do Colégio Brasileiro de Radiologia
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Sara, Leonardo

; Szarf, Gilberto

; Tachibana, Adriano

; Shiozaki, Afonso Akio

; Villa, Alexandre Volney

; Oliveira, Amarino Carvalho de

; Albuquerque, Andrei Skromov de

; Rochitte, Carlos Eduardo

; Nomura, César Higa

; Azevedo, Clerio Francisco

; Jasinowodolinski, Dany

; Tassi, Eduardo Marinho

; Medeiros, Fabio de Morais

; Kay, Fernando Uliana

; Junqueira, Flávia Pegado

; Azevedo, Guilherme S. A.

; Monte, Guilherme Urpia

; Pinto, Ibraim Masciarelli Francisco

; Gottlieb, Ilan

; Andrade, Joalbo

; Lima, João A. C.

; Parga Filho, José Rodrigues

; Kelendjian, Juliana

; Fernandes, Juliano Lara

; Iquizli, Leonardo

; Correia, Luis C. L.

; Quaglia, Luiz Augusto

; Gonçalves, Luiz Flavio Galvão

; Ávila, Luiz Francisco

; Zapparoli, Marcello

; Hadlich, Marcelo

; Nacif, Marcelo Souto

; Barbosa, Márcia de Melo

; Minami, Márcio Hiroshi

; Bittencourt, Marcio Sommer

; Siqueira, Maria Helena Albernaz

; Silva, Marly Conceição

; Lopes, Marly Maria Uellendahl

; Marques, Mateus Diniz

; Vieira, Mônica La Rocca

; Coellho Filho, Otávio Rizzi

; Schvartzman, Paulo R.

; Santos, Raul D.

; Cury, Ricardo C.

; Loureiro, Ricardo

; Cury, Roberto Caldeira

; Sasdelli Neto, Roberto

; Macedo, Robson

; Cerci, Rodrigo Julio

; Faria Filho, Rui Alberto de

; Cardoso, Sávio

; Naves, Thiago

; Magalhães, Tiago Augusto

; Senra, Tiago

; Burgos, Ursula Maria Moreira Costa

; Moreira, Valéria de Melo

; Ishikawa, Walther Yoshiharu

Arquivos Brasileiros de Cardiologia

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Dic 2014, Volumen 103 Nº 6 Paginas 1 - 86

Resumen: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.5935/abc.2014S006 67586 descargas

12.

Avaliação da perda de inserção dentária em pacientes com doença renal crônica em hemodiálise
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Gonçalves, Érica Melo

; Lima, Danilo Lopes Ferreira

; Albuquerque, Sandra Helena C. de

; Carvalho, José Arthur de

; Cariri, Tiago França Araripe

; Oliveira, Cláudia Maria Costa de

Brazilian Journal of Nephrology

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Sep 2011, Volumen 33 Nº 3 Paginas 291 - 294

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

A doença renal crônica (DRC) é uma síndrome clínica decorrente da perda lenta, progressiva e irreversível da taxa de filtração glomerular. A DRC pode apresentar várias manifestações bucais, como xerostomia, estomatite urêmica e periodontite, diagnosticada por meio da perda de inserção clínica (PIC). Foram avaliados 92 indivíduos em tratamento de hemodiálise na Clínica de Hemodiálise Prontorim, na cidade de Fortaleza, Ceará. O exame periodontal foi realizado por meio da mensuração da PIC e apenas 34 pacientes (37%) estavam aptos a realizar exame periodontal. A perda de inserção por indivíduo registrada no grupo de dentados ficou entre 1,31 e 5,27 mm, com média de 2,30 ± 0,96 mm. Dezoito pacientes (52,9%) apresentaram PIC menor que 2 mm, enquanto 16 (47,1%) mostraram-se portadores de periodontite. A perda dentária e a presença de considerável perda de inserção foram observadas neste estudo. Contudo, fatores como status social devem ser considerados em futuras investigações.

Chronic kidney failure (CKF) is a clinical syndrome due to the slow, progressive and irreversible loss of the glomerular filtration rate. CKF may be associated with several oral manifestations, such as xerostomia, uremic stomatitis and periodontitis, diagnosed as clinical attachment loss (CAL). 92 patients, from the Prontorim Hemodialysis Clinic of Fortaleza, Ceará, Brazil, were investigated. Only 34 patients (37%) were eligible for periodontal investigation, which consisted of CAL measurement (values grater than 2 mm diagnosing periodontitis). CAL measurements ranged from 1.31 to 5.27 mm (2.30 ± 0.96 mm). 18 (52.9%) patients had smaller than 2 mm CAL, while 16 (47.1%) had periodontitis. Tooth loss and considerable CAL were observed in this study. Nevertheless, factors such as social status should be considered in further investigations.

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13.

Puberdade precoce central como única manifestação de cisto aracnoide supraselar
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Aun, Adriana Mangue E.

; Hayashi, Keila

; Carvalho, Cecília Freire C. de

; Baptista, Maria Tereza M.

; Lemos-Marini, Sofia Helena V. de

; D'Souza-Li, Lilia Freire R.

; Guerra-Junior, Gil

Revista Paulista de Pediatria

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Mar 2011, Volumen 29 Nº 1 Paginas 126 - 129

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

OBJETIVO: Os cistos aracnoides são achados raros. Em 10% dos casos, sua localização é supraselar e ocorrem quase exclusivamente em crianças. Em geral, apresentam manifestações neurológicas e visuais, sendo incomum a puberdade precoce central como sinal clínico de sua presença. DESCRIÇÃO DO CASO: Menina avaliada aos dois anos e sete meses por telarca iniciada com um ano e oito meses e pubarca e axilarca com dois anos, com aumento da velocidade de crescimento (13cm/ano) e da idade óssea (sete anos e um mês). Ao exame, apresentou peso de 22,6kg (Z+4,0), estatura de 106cm (Z+3,5) e Tanner de M3P2. Exames realizados: teste de estímulo com GnRH (LH basal 8,3 UI/L, pico aos 30 minutos 94,3 UI/L; FSH basal=10,1 UI/L, pico aos 30 minutos 29,5 UI/L), ressonância nuclear magnética de crânio com cisto aracnoide supraselar e demais testes de função hipofisária normais. Foi iniciado tratamento com análogo de GnRH. Atualmente, aos quatro anos e três meses com estadio puberal M3P2, velocidade de crescimento e desenvolvimento neuropsicomotor normais para a idade. COMENTÁRIOS: A puberdade precoce central pode ser manifestação única de um cisto aracnoide, sendo essenciais o diagnóstico e o tratamento precoces, além de seguimento prolongado, uma vez que outras disfunções hipofisárias podem ocorrer tardiamente.

OBJECTIVE: Arachnoid cysts (AC) are a rare finding; 10% of them are suprasellar and occur almost exclusively in children. They are frequently associated with neurological and visual manifestations. Central precocious puberty as a sole manifestation is uncommon. CASE DESCRIPTION: Girl evaluated at the age of two years and seven months. She started breast development at the age of one year and eight months, pubic and axillary hair at the age of two years, with growth velocity acceleration (13cm/year) and increased bone age (seven years and one month). On exam: weight: 22.6kg (Z+4.0), height: 106cm (Z+3.5) and puberal stage of B3P2. The GnRH stimulus test was performed (basal LH 8.3 IU/L, at 30 minutes 94.3 IU/L; FSH basal=10.1 IU/L, at 30 minutes 29.5 IU/L). Nuclear Magnetic Resonance of the skull showed a suprasellar arachnoid cyst. Others stimulation tests were performed and excluded pituitary deficiencies. Treatment with a GnRH analog was started. At the age of four years and three months, she was B3P2, with normal growth velocity and neurologic development. COMMENTS: Central precocious puberty can be the only manifestation of AC. It is essential to establish early diagnosis and treatment. A prolonged follow up is recommended, since late pituitary dysfunctions can occur.

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14.

Estrutura vertical da troposfera associada com nuvens Cumulunimbus e Nimbustratus em Pelotas, RS
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Fedorova, Natalia

; Carvalho, Maria Helena de

; Levit, Vladimir

; Barbieri, Paulo R. B.

; Gonçalves, André M.

; Alves, Eliane P.

; Signorini, Elizabeth

; Pinheiro, Gilsane M. C.

; Marques, Júlio R. Q.

; Oliveira, Vladair M. de

; Almeida, Antonio J. de

Revista Brasileira de Meteorologia

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Dic 2010, Volumen 25 Nº 4 Paginas 487 - 500

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

As condições termodinâmicas do desenvolvimento de nuvens Cumulunimbus (Cb) e Nimbustratus (Ns) e formação de precipitações na cidade de Pelotas são estudadas utilizando-se dados do NCEP (National Center for Environmental Prediction, Washington) para os níveis padrões e dados meteorológicos convencionais. Analisou-se a freqüência das nuvens Cb e Ns durante três anos, para as quatro estações do ano, e calcularam- se os índices de instabilidade (Showalter, lifted, K and standard totals-totals) e a energia potencial de convecção. Foram identificados cinco tipos de perfis verticais de temperatura e umidade para os dias em que foram verificadas nuvens Cb e Ns, através de dados de radiossondagens de Porto Alegre, e das análises do NCEP. Apresentam-se os resultados da análise da instabilidade atmosférica e são discutidos os problemas da previsão de nuvens Cb e Ns, utilizando os índices de instabilidade.

The thermodynamic conditions of Cumulunimbus (Cb) and Nimbustratus (Ns) cloudiness development and precipitation formation in Pelotas city were studied using NCEP (National Centers for Environmental Prediction, Washington) data for standard levels and conventional meteorological data. The frequency of the Cb and Ns cloudiness during three years and for each seasons was analyzed. Stability indexes (Showalter, lifted, K and standard totals-totals) and the convective available potential energy were calculated. Five types of vertical profiles of temperature and humidity for days with Cb and Ns clouds were identified through radiosonde data over Porto Alegre and NCEP analysis. The results of the atmospheric instability analysis are presented and problems envolving the Cb and Ns cloudiness forecasting, using the stability indexes, are discussed.

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15.

Produção de biomassa por cultivos de cobertura do solo e produtividade do algodoeiro em plantio direto
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Ferreira, Alexandre Cunha de Barcellos

; Lamas, Fernando Mendes

; Carvalho, Maria da Conceição Santana

; Salton, Júlio César

; Suassuna, Nelson Dias

Pesquisa Agropecuária Brasileira

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Jun 2010, Volumen 45 Nº 6 Paginas 546 - 553

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

O objetivo deste trabalho foi avaliar a produção, a persistência da matéria seca e a eficiência da dessecação em espécies vegetais utilizadas para cultivos de cobertura do solo, e quantificar seus efeitos sobre a produtividade do algodoeiro em plantio direto. O trabalho foi realizado em Santa Helena de Goiás, GO, com 16 tratamentos: Panicum maximum, cultivares Mombaça, Tanzânia e Massai; Urochloa brizantha, cultivares Piatã, Xaraés, Marandu e MG4; U. decumbens; Paspalum atratum cv. Pojuca; Sorghum bicolor cultivares Santa Eliza e BRS 700; Pennisetum glaucum cv. ADR 500; Raphanus sativus; Eleusine coracana, Crotalaria spectabilis, além da testemunha em pousio. As espécies foram semeadas no início de março (2007). As espécies com menores produtividades e persistência da matéria seca foram C. spectabilis, E. coracana e R. sativus. As produtividades de algodão em caroço e fibra foram maiores no cultivo sobre palhas residuais das cultivares Tanzânia e Mombaça de P. maximum, em comparação às observadas com uso de P. atratum cv. Pojuca, R. sativus e pousio. Em geral, S. bicolor, P. glaucum e as cultivares Tanzânia e Mombaça de P. maximum, e MG4, Piatã e Xaraés de U. brizantha apresentam produção e persistência da matéria seca adequadas para o cultivo do algodoeiro no sistema de plantio direto, no cerrado brasileiro.

The objectives of this work were to evaluate biomass production and persistence and the desiccation efficiency in plant species used as cover crops, and to quantify its effects on cotton yield in a no-tillage system. The study was carried out in Santa Helena de Goiás, GO, Brazil, using 16 plant species: Panicum maximum, cultivars Mombaça, Tanzânia and Massai; Urochloa brizantha, cultivars Piatã, Xaraés, Marandu and MG4; U. decumbens; Paspalum atratum cv. Pojuca; Sorghum bicolor cultivars Santa Eliza and BRS 700; Pennisetum glaucum cv. ADR 500; Raphanus sativus; Eleusine coracana, Crotalaria spectabilis, and fallow plants as control. The species were sown early in March-2007. The lower dry biomass productivity and persistence were obtained with C. spectabilis, E. coracana, and R. sativus. Cotton seed and lint yield were higher when it was cultivated after the cultivars Tanzânia and Mombaça of P. maximum, in comparison to the ones observed using P. atratum cv. Pojuca, R. sativus, and fallow plants. Generally, S. bicolor, P. glaucum and the cultivars Tanzânia and Mombaça of P. maximum, and MG4, Piatã and Xaraés of U. brizantha have biomass persistence and productivity suitable for cotton cultivation in no-tillage systems in the Brazilian savannah.

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