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ABSTRACT Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide. The Brazilian Society of Hepatology (SBH) published in 2020 the updated recommendations for the diagnosis and treatment of HCC. Since then, new data have emerged in the literature, including new drugs approved for the systemic treatment of HCC that were not available at the time. The SBH board conducted an online single-topic meeting to discuss and review the recommendations on the systemic treatment of HCC. The invited experts were asked to conduct a systematic review of the literature on each topic related to systemic treatment and to present the summary data and recommendations during the meeting. All panelists gathered together for discussion of the topics and elaboration of the updated recommendations. The present document is the final version of the reviewed manuscript containing the recommendations of SBH and its aim is to assist healthcare professionals, policy-makers, and planners in Brazil and Latin America with systemic treatment decision-making of patients with HCC.

RESUMO O carcinoma hepatocelular (CHC) é uma das principais causas de mortalidade relacionada a câncer no Brasil e no mundo. A Sociedade Brasileira de Hepatologia (SBH) publicou em 2020 a atualização das recomendações da SBH para o diagnóstico e tratamento do CHC. Desde então, novas evidências científicas sobre o tratamento sistêmico do CHC foram relatadas na literatura médica, incluindo novos medicamentos aprovados que não estavam disponíveis na época do último consenso, levando a diretoria da SBH a promover uma reunião monotemática on-line para discutir e rever as recomendações sobre o tratamento sistêmico do CHC. Um grupo de experts foi convidado para realizar uma revisão sistemática da literatura e apresentar uma atualização, baseada em evidências científicas, sobre cada tópico relacionado ao tratamento sistêmico e a apresentar os dados e recomendações resumidas durante a reunião. Todos os painelistas se reuniram para discutir os tópicos e elaborar as recomendações atualizadas. O presente documento é a versão final do manuscrito revisado, contendo as recomendações da SBH, e seu objetivo é auxiliar os profissionais de saúde, formuladores de políticas e planejadores no Brasil e na América Latina na tomada de decisões sobre o tratamento sistêmico de pacientes com CHC.

https://doi.org/10.1590/s0004-2803.202301000-14

Beak trimming in japanese quails at initial phase is an alternative to reduce the negative effects of feather pecking
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Cruvinel, Jéssica Moraes

; Montenegro, Andressa Takahara

; Ouros, Caio Cesar dos

; Alves, Kauan de Souza

; Ribeiro, Gabriela Costa

; Santos, Tatiane Souza dos

; Molino, Andrea de Britto

; Garcia, Edivaldo Antônio

Acta Scientiarum. Animal Sciences

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2022, Volumen 44 elocation e54129

Resumen: En | Texto: En | PDF: En

ABSTRACT. Regarding the lack of standardized methods for beak trimming to reduce feather pecking in Japanese quail, the present study aimed to compare two ages and 3 methods of beak trimming, evaluating the performance, egg quality and feather pecking. One-day-old Japanese quails (n = 770; 22 birds cage-1), at the initial phase, and 36-day-old (n = 630; 18 birds cage-1), at the production phase, were assigned to a completely randomized design, consisting of 7 treatments with 5 replicates. The treatments were: non-trimmed (NT), cauterization of approximately 1/3 at 14 days-of-age (CAUT 14) and at 28 days-of-age (CAUT 28), moderately trimmed to approximately 1/3 beak at 14 days-of-age (MOD 14) and at 28 days-of-age (MOD 28), severely trimmed to 1/3-1/2 beak at 14 days-of-age (SEV 14) and at 28 days-of-age (SEV 28). Data were analyzed using Minitab®. The results indicated that beak trimming methods applied did not influence the performance and egg quality. Quails subjected to MOD 28 and SEV (14 and 28) presented lower feed conversion per egg mass compared to NT. However, MOD 14 and SEV were more efficient in preventing feather pecking behavior.

https://doi.org/10.4025/actascianimsci.v44i1.54129

What do Cochrane systematic reviews say about ultrasound-guided vascular access?
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Attie, Gabriela Araújo

; Flumignan, Carolina Dutra Queiroz

; Silva, Melissa Andreia de Moraes

; Barros, Edivando de Moura

; Daolio, Raul Muffato

; Guedes Neto, Henrique Jorge

; Baptista-Silva, José Carlos Costa

; Amorim, Jorge Eduardo de

; Nakano, Luis Carlos Uta

; Flumignan, Ronald Luiz Gomes

Sao Paulo Medical Journal

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May 2019, Volumen 137 Nº 3 Paginas 284 - 291

Resumen: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Ultrasonography is currently used in investigating many vascular diseases, especially for guiding vascular access. OBJECTIVE: The objective here was to summarize the evidence from Cochrane systematic reviews (SRs) on the effects of ultrasound-guided vascular access as an intervention approach. DESIGN AND SETTING: Review of SRs, conducted in the Division of Vascular and Endovascular Surgery of Universidade Federal de São Paulo. METHODS: A broad search was conducted in the Cochrane Database of Systematic Reviews to retrieve any Cochrane SRs that assessed the effects of ultrasound guidance as a therapeutic approach towards performing any vascular access. The key characteristics and results of all the reviews included were summarized and discussed. RESULTS: Three SRs on venous access at all ages and one review on arterial access in pediatric participants were included. There was low to moderate certainty of evidence that ultrasound increased the success rate from the first puncture and the overall success rate of the procedure; and reduced the total rate of perioperative and postoperative adverse events, number of punctures, time needed to achieve success and rate of failure to place catheters. CONCLUSION: Evidence of low to moderate quality showed that ultrasound-guided vascular access seems to reduce the total rate of perioperative and postoperative complications/adverse effects, number of punctures, time needed to achieve success and rate of failure to perform venous catheterization in adults and arterial punctures in children. There is a lack of information regarding ultrasound-guided arterial puncture in adults. Further studies are still imperative for reaching solid conclusions, especially regarding arterial ultrasound-guided access.

https://doi.org/10.1590/1516-3180.2019.0113070519 901 descargas

Supplementation with arginine in the diet of Nile tilapia reared in net cages
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Fujimoto, Rodrigo Yudi

; Santos, Rudã Fernandes Brandão

; Pala, Gabriela

; Gallani, Sílvia Umeda

; Valladão, Gustavo Moraes Ramos

; Morais, Gisele Cavalcante

; Lee, James Tony

; Sousa, Natalino da Costa

; Cunha, Fernanda dos Santos

; Maria, Alexandre Nizio

; Carneiro, Paulo César Falanghe

; Pilarski, Fabiana

Pesquisa Agropecuária Brasileira

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2019, Volumen 54 elocation e01099

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi avaliar o efeito de concentrações de arginina dietética sobre a saúde da tilápia-do-nilo (Oreochromis niloticus), em tanques-rede. O experimento foi realizado em delineamento inteiramente casualizado, com quatro tratamentos (2,3, 2,9, 3,5 e 4,1% de arginina em relação à matéria seca na dieta) e três repetições, em 12 tanques-rede de 8 m3, com 4.000 tilápias revertidas sexualmente (63±20 g, 500 peixes m-3). Determinaram-se o desempenho produtivo e a saúde dos peixes. Avaliaram-se os parâmetros bioquímicos e hematoimunológicos e os aspectos morfológicos das brânquias e do fígado. A inclusão de arginina não proporcionou diferenças significativas no desempenho produtivo. Porém, a suplementação de arginina a 3,5% de concentração melhorou os parâmetros bioquímicos e de contagem de leucócitos, tendo consequentemente melhorado o sistema imunológico. A concentração de arginina a 4.1% causou degeneração lipídica, representada pelo aumento dos níveis da alanina aminotransferase e pela diminuição dos níveis de albumina, ureia, lactato e glicose. A suplementação com arginina acima de 2,3% e abaixo de 3,5%, nas dietas de tilápias criadas em tanques-rede, promove melhoras no sistema imunológico dos peixes, sem provocar efeitos morfológicos e fisiológicos deletérios.

Abstract: The objective of this work was to evaluate the effect of dietary arginine concentrations on the health status of Nile tilapia (Oreochromis niloticus) cultivated in cages. The experiment was carried out in a completely randomized design with four treatments (2.3, 2.9, 3.5, and 4.1% arginine in dry matter) and three replicates, in 12 net cages of 8 m3, containing 4,000 sexually reverted tilapia (63±20 g, at 500 fish m-3). Fish productive performance and health were evaluated. Biochemical, hematological, and immunological parameters, as well as the morphological aspects of gills and liver, were evaluated. Arginine inclusion did not cause significant differences in fish growth performance. However, arginine supplementation at 3.5% concentration improved the biochemical parameters and leucocyte counts, consequently improving the immune system. The arginine concentration of 4.1% caused lipid degeneration, shown by the increase of alanine aminotransferase and the decrease of albumin, urea, lactate, and glucose. Arginine supplementation above 2.3% and below 3.5%, in the diets of tilapia reared in cages, improves fish immune system, without adverse morphological and physiological effects.

https://doi.org/10.1590/s1678-3921.pab2019.v54.01099 1127 descargas

Molecular markers indicate the phylogenetic identity of southern Brazilian sea asparagus: first record of Salicornia neei in Brazil
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Costa, César S.B.

; Kadereit, Gudrun

; Freitas, Gabriela Peres Moraes de

Rodriguésia

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2019, Volumen 70 elocation e03122017

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Abstract Molecular phylogenetic analyses based on ETS, ITS and atpB - rbcL spacer sequences assessed the phylogenetic status of the southern Brazil sea asparagus species of the genus Salicornia (Salicornioideae, Amaranthaceae). Accessions of Patos Lagoon estuary (32° S) were obtained from wild plants and two pure line lineages, selected from contrasting prostrate (BTH1) and decumbent (BTH2) ecomorphotypes found locally. Patos Lagoon wild plants, BTH1 and BTH2 f4 progenies showed 100% identical sequences for the atpB - rbcL and ITS spacers, only two mutations for ETS. Comparison of the sequences of these three markers with GenBank records confirmed the identity of Brazilian accessions as Salicornia neei . Maximum-likelihood phylogenetic analysis of ETS sequences indicated that the southern Brazilian accessions of Salicornia certainly are not close to any of the Salicornia ambigua accessions in GenBank, which are restricted to the northern hemisphere, nor are they related to any Salicornia fruticosa/Salicornia perennis clade accessions, which are also restricted to Eurasia. All above cited species have been wrongly applied to the southern Brazil sea asparagus.

https://doi.org/10.1590/2175-7860201970039 793 descargas

New insights into cortisol levels in PTSD
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Costa, Gabriela de Moraes

Brazilian Journal of Psychiatry

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Jun 2016, Volumen 38 Nº 2 Paginas 176 - 176

Resumen: En | Texto: En | PDF: En

https://doi.org/10.1590/1516-4446-2015-1795 3658 descargas

Single-tube nested PCR assay with in-house DNA extraction for Mycobacterium tuberculosis detection in blood and urine
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Lima, Juliana Figueirêdo da Costa

; Guedes, Gabriela de Moraes Rêgo

; Lima, Juliana Falcão de Araújo

; Lira, Laís Ariane de Siqueira

; Santos, Fabiana Cristina Fulco

; Arruda, Mercia Eliane de

; Montenegro, Lílian Maria Lapa

; Schindler, Haiana Charifker

Revista da Sociedade Brasileira de Medicina Tropical

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Dic 2015, Volumen 48 Nº 6 Paginas 731 - 738

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Abstract: INTRODUCTION : Molecular analyses are auxiliary tools for detecting Koch's bacilli in clinical specimens from patients with suspected tuberculosis (TB). However, there are still no efficient diagnostic tests that combine high sensitivity and specificity and yield rapid results in the detection of TB. This study evaluated single-tube nested polymerase chain reaction (STNPCR) as a molecular diagnostic test with low risk of cross contamination for detecting Mycobacterium tuberculosis in clinical samples. METHODS: Mycobacterium tuberculosis deoxyribonucleic acid (DNA) was detected in blood and urine samples by STNPCR followed by agarose gel electrophoresis. In this system, reaction tubes were not opened between the two stages of PCR (simple and nested). RESULTS: STNPCR demonstrated good accuracy in clinical samples with no cross contamination between microtubes. Sensitivity in blood and urine, analyzed in parallel, was 35%-62% for pulmonary and 41%-72% for extrapulmonary TB. The specificity of STNPCR was 100% in most analyses, depending on the type of clinical sample (blood or urine) and clinical form of disease (pulmonary or extrapulmonary). CONCLUSIONS: STNPCR was effective in detecting TB, especially the extrapulmonary form for which sensitivity was higher, and had the advantage of less invasive sample collection from patients for whom a spontaneous sputum sample was unavailable. With low risk of cross contamination, the STNPCR can be used as an adjunct to conventional methods for diagnosing TB.

https://doi.org/10.1590/0037-8682-0210-2015 3245 descargas

Influência da modalidade de reconto na avaliação do desempenho de escolares em compreensão leitora
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KIDA, Adriana de Souza Batista

; BUENO, Gabriela Juliane

; LIMA, Vânia Lúcia Costa de Carvalho

; ROSSI, Suelen Graton

; NEPOMUCENO, Pablo Felicio

; MARTIN, Mariana de Moraes Maldonado

; ÁVILA, Clara Regina Brandão de

Estudos de Psicologia (Campinas)

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Dic 2015, Volumen 32 Nº 4 Paginas 605 - 615

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Este estudo buscou estudar a influência da modalidade de reconto sobre a avaliação da compreensão leitora. Avaliaram-se 34 escolares do 2º ao 5º ano do Ensino Fundamental, sem queixas de leitura, agrupados em: 1) Grupo Reconto Oral: 19 crianças que recontaram oralmente texto narrativo e expositivo lidos; 2) Grupo Reconto Escrito: 15 que o fizeram por escrito. A análise dos recontos quantificou proposições de ideia central, detalhe, inferências e número de enlaces. Estabeleceu-se, também, o padrão de compreensão (3-0, do melhor para o pior desempenho). Resultados evidenciaram semelhanças entre as médias de desempenho dos grupos nas variáveis do reconto de texto narrativo. Para o expositivo, houve diferença para enlaces de primeiro nível (t = -2,114, p = 0,042), com maior média do Grupo reconto escrito. Concluiu-se, portanto, que a modalidade do reconto não influenciou a avaliação da compreensão de textos narrativos, mas o reconto escrito de textos expositivos favoreceu o aparecimento de enlaces entre ideias centrais.

The aim of the present study was to investigate the influence of the retelling strategy modality on the assessment of reading comprehension. Thirty-four 2nd-5th grade students (elementary school) without reading difficulties were evaluated and grouped as follows: Group 1. Oral retelling: students orally reconstructed narrative and expository texts they read (19 students); Group 2. Writing retelling: students retold these same stories in writing (15 students). The analysis conducted assessed retelling in terms of: proposition of central idea, details, inferences, and number of links. A performance reference standard (3-0) was also established from the best to the worst performance. The results obtained showed similarity between the average performance of the variables of the oral narrative text retelling groups. As for the expository texts, there were differences in the first level of links (t = -2.114, p = 0.042), and the highest average performance was found for the writing retelling group. It can be concluded that the retelling strategy modality did not influence the evaluation of the understanding of narrative texts, but the written retelling of expository texts influenced the connection of central ideas.

https://doi.org/10.1590/0103-166X2015000400004 3209 descargas

Osteoarticular tuberculosis in an HIV-positive patient: a case report
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Guedes, Gabriela de Moraes Rêgo

; Lima, Juliana Figueirêdo da Costa

; Santos, Fabiana Cristina Fulco

; Salazar, Marcela Pereira

; Guarines, Klarissa Miranda

; Montenegro, Lílian Maria Lapa

; Pitta, Ivan da Rocha

; Schindler, Haiana Charifker

Revista da Sociedade Brasileira de Medicina Tropical

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Jun 2014, Volumen 47 Nº 3 Paginas 394 - 396

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The authors report a case of a 38-year-old HIV-positive woman, with subcutaneous nodules on the thoracic region with 3 months of evolution. Clinical, laboratory, and epidemiological features were evaluated and associated with apparent damage to the T11-T12 vertebrae, identification by imaging tests, positivity in a polymerase chain reaction-based test, and reactivity to the Mantoux tuberculin skin test (PPD-RT 23). The patient was diagnosed with osteoarticular tuberculosis and received treatment for a year, and clinical cure was achieved.

https://doi.org/10.1590/0037-8682-0216-2013 2320 descargas

10.

Pregnant crack addicts in a psychiatric unit
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Costa, Gabriela de Moraes

; Soibelman, Mauro

; Zanchet, Daniel Luís

; Costa, Patricia de Moraes

; Salgado, Carlos Alberto Iglesias

Jornal Brasileiro de Psiquiatria

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2012, Volumen 61 Nº 1 Paginas 8 - 12

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OBJETIVO: Caracterizar uma amostra de 85 gestantes dependentes de crack admitidas para desintoxicação numa unidade de internação psiquiátrica. MÉTODO: Foram avaliadas, de forma transversal, variáveis sociodemográficas, clínico-obstétricas e informações sobre o seu estilo de vida. RESULTADOS: A idade de início de uso do crack variou dos 11 aos 35 anos (mediana = 21). Aproximadamente, 25% das pacientes fumavam mais de 20 pedras de crack em um dia típico de uso (mediana = 10; mín-máx = 1-100). Além do crack, as drogas mais utilizadas eram: tabaco (76; 89,4%), álcool (54; 63,5%) e maconha (44; 51,8%). Roubo foi relatado por 41,2% (32 pacientes), prisão por 24,7% (21), troca de sexo por dinheiro/drogas por 44,7% (38) e abandono do lar por 38,8% (33); 15,3% (13) tinham soropositividade para HIV, 5,9% (5) para HCV, 1,2% (1) para HBV e 8,2% (7) para sífilis. Após alta da unidade de internação psiquiátrica, somente 25% da amostra deram continuidade ao tratamento no ambulatório de dependência química. CONCLUSÃO: Comportamentos de risco para DSTs, altas taxas de HIV e sífilis, elevado uso de outras drogas e envolvimento em atividades ilegais fazem parte do estilo de vida caótico dessas mulheres. Programas de prevenção e intervenção dirigidos à natureza multifatorial dessa condição precisam ser desenvolvidos.

OBJECTIVE: In this study we aim to characterize a sample of 85 pregnant crack addicts admitted for detoxification in a psychiatric inpatient unit. METHOD: Cross-sectional study. Sociodemographic, clinical, obstetric and lifestyle information were evaluated. RESULTS: Age of onset for crack use varied from 11 to 35 years (median = 21). Approximately 25% of the patients smoked more than 20 crack rocks in a typical day of use (median = 10; min-max = 1-100). Tobacco (89.4%), alcohol (63.5%) and marijuana (51.8%) were the drugs other than crack most currently used. Robbery was reported by 32 patients (41.2%), imprisonment experience by 21 (24.7%), trade of sex for money/drugs by 38 (44.7%), home desertion by 33 (38.8%); 15.3% were positive for HIV, 5.9% for HCV, 1.2% for HBV and 8.2% for syphilis. After discharge from the psychiatric unit, only 25% of the sample followed the proposed treatment in the chemical dependency outpatient service. CONCLUSION: Greater risky behaviors for STD, as well as high rates of maternal HIV and Syphilis were found. Moreover, the high rates of concurrent use of other drugs and involvement in illegal activities contribute to show their chaotic lifestyles. Prevention and intervention programs need to be developed to address the multifactorial nature of this problem.

5765 descargas Citado 8 veces en SciELO

11.

Parasitas de populações naturais e artificiais de tucunaré (Cichla spp.)
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Araujo, Cleusa Suzana Oliveira de

; Barros, Maria Claudene

; Gomes, Ana Lucia da Silva

; Varella, Angela Maria Bezerra

; Viana, Gabriela de Moraes

; Silva, Nathalia Pereira da

; Fraga, Elmary da Costa

; Andrade, Sanny Maria Sampaio

Revista Brasileira de Parasitologia Veterinária

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Mar 2009, Volumen 18 Nº 1 Paginas 34 - 38

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Os ciclídeos, peixes economicamente importantes na região, foram coletados no médio rio Negro (Cichla orinocensis, C. monoculus e C. temensis) e na iIlha da Marchantaria (C. monoculus), no Amazonas e em três açudes do Piauí (C. kelberi). Para verificar a ocorrência de parasitas as brânquias, narinas e intestino foram removidos e observados em microscópio esteroscópio, a boca a olho nu. Os parasitas encontrados foram retirados e armazenados em álcool 70% para posterior identificação. Dos 96 espécimes analisados provenientes do rio Negro 51 (52%) estavam parasitadas; dos 34 da ilha da Marchantaria 16 (47%) e dos 50 dos açudes do Piauí, apenas dois (4%). Nos peixes coletados no Amazonas, as brânquias estavam parasitadas por Ergailus coatiarus, Argulus amazonicus, Acusicola tucunarense e a boca por Braga cichlae, enquanto que os peixes do Piauí não apresentaram parasitas branquiais, mas registrou-se a ocorrência do nematóide Procamallanus (Spirocamallanus) inopinatus, parasita intestinal.

The cichlids, economically important fish specie in the region, were collected along the Negro River (Cichla orinocensis, C. monoculus e C. temensis) and in the Marchantaria Island (C. monoculus) Amazon State and in three reservoirs localized in the Piauí State. In order to verify the occurrence of parasites, gills, nostrils and the intestine were removed and observed by stereomicroscope and the mouth by naked eyes. The observed parasites were isolated and conserved in 70% ethanol for posterior identification. From 96 specimens collected in Negro River, 51 specimens (52%) were parasitized. In the Marchantaria Island from 34 specimens collected, 16 (47%) showed the presence of parasites, and from 50 specimens collected in the reservoirs only 2 (4%) were parasitized. In fishes collected in the Amazon State, the grill was parasitized by Ergailus coatiarus, Argulus amazonicus, Acusicola tucunarense and the mouth by Braga cichlae, whereas the species collected in the Piauí State did not show the presence of parasites in the grill, but the occurrence of Procamallanus (Spirocamallanus) inopinatus an intestinal nematode parasite.

https://doi.org/10.4322/rbpv.01801006 6906 descargas Citado 1 vez en SciELO

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