Abstract With the COVID-19 pandemic, many diagnostic tests (molecular or immunological) were rapidly standardised, given the urgency of the situation, many are still in the process of being validated. The main objective of this study was to review the aspects of the diagnostic kits approved in Brazil and their application in the different federative units to gather epidemiological information. In order to achieve these objectives, a survey was carried out on the data available at the regulatory agency (ANVISA) and in the literature. The main countries that have registered products in Brazil are China (51.4%), Brazil (16.6%), South Korea (9.2%), USA (8.8%) and Germany (3.6%). The methodologies of these products are based on the detection of nucleic-acid (15.8%), antigen (13%) and antibody (71.2%). In the immunological tests, it was verified that the sensitivity ranged from 55 to 100% and the specificity from 80 to 100%. The percentage of cases in the samples tested in Brazil is elevated in almost all federative units since eight states showed 40% of positive cases in tested samples, while 18 states displayed between 20 and 40%. In conclusion, this review showed that Brazil is dependent on external technology to respond to pandemics, epidemics and endemics disease and needs to improve its biotechnological scheme to solve further diseases outbreaks.

Abstract Purpose: To compare the satisfaction levels about the surgery and anesthesia management, and to analyze the postoperative outcomes of patients undergoing Gastric Bypass and Sleeve Gastroplasty surgeries in a private hospital in Sao Luís-MA. Methods: The sample consisted of patients undergoing Bypass and Sleeve bariatric surgeries from August 2018 to August 2019, who were in the range of 18 and 70 years old and had not used drugs or presented cardiac arrhythmias, dilated cardiomyopathy, and conduction disorder heart. Data were collected from the evaluation forms and recorded in a form with closed questions. Results: Most patients were female (Bypass – 56% and Sleeve – 67.4%) and aged between 30 and 39 years old (Bypass – 32% and Sleeve – 55.8%). Information (Bypass – 92% and Sleeve – 86.1%) was the highest satisfaction index found. Sleepiness in the immediate postoperative period (Bypass – 92% and Sleeve – 93%) was the main side effect. There were no postoperative complications in patients between the two types of surgery. Conclusions: Patients submitted to Bypass and Sleeve were completely satisfied with the perioperative management. There was no statistically significant difference when comparing adverse effects between the techniques.

RESUMO Objetivo Avaliar os efeitos da terapia fotodinâmica (PDT) na dura-máter usando os fotossensibilizadores cloreto de alumínio ftalocianina e azul de metileno em ensaios in vivo. Métodos Cinquenta e seis ratos Wistar machos divididos em dois grupos; um submetido à PDT e o outro submetido aos fotossensibilizadores sem a fotoativação (controle). Os fotossensibilizadores foram aplicados sobre a dura-máter depois de laminectomia no nível T10. Os métodos de avaliação usados foram a escala de avaliação funcional de Basso, Beattie e Bresnahan (BBB) e o estudo da dura-máter por microscopia óptica. Resultados Não foram observadas alterações da atividade motora dos animais submetidos à PDT com relação ao grupo controle. A avaliação histológica e histopatológica não mostrou diferenças entre o grupo exposto aos fotossensibilizadores ativados e o grupo controle, com relação ao processo inflamatório e à necrose tecidual. Conclusões O uso conjunto de PDT e os fármacos fotossensibilizantes cloreto de alumínio ftalocianina e azul de metileno não induziu efeitos neurotóxicos clínicos e/ou alterações histológicas sobre a dura-máter dos animais estudados. Nível de evidência V; Opinião de Especialista.

ABSTRACT Objective To evaluate the effects of photodynamic therapy (PDT) on the dura mater using the photosensitizers aluminum chloride phthalocyanine and methylene blue in in vivo assays. Methods Fifty-six male Wistar rats were divided into two groups; one submitted to PDT and the other submitted to the photosensitizers without their photoactivation (control). The photosensitizers were applied to the dura mater after laminectomy at the T10 level. The methods used for assessment were the Basso, Beattie and Bresnahan (BBB) functional evaluation scale and study of the dura mater by light microscopy. Results No changes in motor activity were observed in the animals submitted to PDT compared to control. Histological and pathological evaluation did not show any differences between the group exposed to activated photosensitizers and the control group with regard to the inflammatory process and tissue necrosis. Conclusion The joint use of PDT with the photosensitizing pharmaceuticals aluminum chloride phthalocyanine and methylene blue did not induce any clinical neurotoxic effects or histological changes in the dura mater of the animals studied. Level de evidence V; Expert Opnion.

RESUMEN Objetivo Evaluar los efectos de la terapia fotodinámica (PDT) en la duramadre utilizando los fotosensibilizadores de ftalocianina de aluminio clorada y azul de metileno en ensayos in vivo. Métodos Cincuenta y seis ratas Wistar machos se dividieron en 2 grupos; uno fue sometido a PDT y el otro sometido a fotosensibilizadores sin fotoactivación (control). Los fotosensibilizadores se aplicaron a la duramadre después de la laminectomía en el nivel T10. Los métodos de evaluación utilizados fueron la escala de evaluación funcional de Basso, Beattie y Bresnahan (BBB) y el estudio de la duramadre mediante microscopía óptica. Resultados No hubo cambios en la actividad motora de los animales sometidos a PDT en relación con el grupo de control. La evaluación histológica e histopatológica no mostró diferencias entre el grupo expuesto a fotosensibilizadores activados y el grupo de control con respecto al proceso inflamatorio y la necrosis tisular. Conclusiones El uso conjunto de PDT con las sustancias fotosensibilizadores ftalocianina de aluminio clorada y azul de metileno no indujo efectos neurotóxicos clínicos o cambios histológicos en la duramadre de los animales estudiados. Nivel de evidencia V; Opinión del Especialista.

Com base na análise de editoriais do semanário Brasil, Urgente (1963-1964), o presente artigo ensaia algumas interpretações acerca do conteúdo veiculado por esse hebdomadário de inspiração cristã. Com o objetivo de se legitimar perante os movimentos sociais que também defendiam os direitos da pessoa humana, o jornal lançou mão de recursos variados e inconstantes. Desse modo, o pluralismo de ideias, presentes nas páginas combativas de Brasil, Urgente, variava de uma postura defensora da terceira via até uma opção de fé reorientada pela racionalidade da práxis social.

Based on the analysis of certain editorials of the weekly publication Brazil, Urgent (1963-1964), this article attempts some interpretations concerning the content transmitted by that weekly paper of Christian inspiration. With the objective of being legitimated before the social movements that also defended the human being's rights, the newspaper used various and inconstant resources. Thus, the pluralism of ideas, which was present in the combative pages of Brazil, Urgent, varied from a defensive posture of the third path to an option of faith reoriented by the rationality of the social praxis.

Basé sur l'analyse des points de vue de l'hébdomadaire Brésil, Urgent (1963-1964), cet article avance quelques interprétations sur le contenu publié par ce journal d'inspiration chrétienne. Dans le but de se légitimer devant les mouvements sociaux qui défendaient aussi les droits de la personne humaine, le journal a utilisé de ressources variées et inconstantes. Le pluralisme d'idées, présent dans les pages combatives de Brésil, Urgent, pouvait ainsi aller de la défense de la troisième voie jusqu'a une option de foi reorientée par la rationalité de la praxis sociale.