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RESUMO Os canabinoides compreendem os endocanabinoides, fitocanabinoides e os canabinoides sintéticos e desempenham ações no sistema nervoso central e periférico. Uma quantidade enorme de publicações tem sido lançada nos últimos anos, embora a cannabis seja conhecida por milênios. Os Departamentos Científicos da Academia Brasileira de Neurologia descreveram as evidências do uso médico em suas áreas. A literatura está em constantes mudanças e possíveis novas evidências podem surgir nos próximos dias ou meses. A prescrição dessas substâncias deve ser discutida com os pacientes e suas famílias, com conhecimento sobre eventos adversos e sua eficácia.

ABSTRACT Cannabinoids comprehend endocannabinoids, phytocannabinoids, and synthetic cannabinoids, with actions both in the central and peripherical nervous systems. A considerable amount of publications have been made in recent years, although cannabis has been known for over a thousand years. Scientific Departments from the Brazilian Academy of Neurology described evidence for medical use in their areas. Literature is constantly changing, and possible new evidence can emerge in the next days or months. Prescription of these substances must be discussed with patients and their families, with knowledge about adverse events and their efficacy.

https://doi.org/10.1590/0004-282x-anp-2020-0432 1049 descargas

Interobserver Agreement of the Static Methods of Evaluating the Types of Footprint in Runners
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Macedo, Rafael Rocha

; Kanashiro, Thiago Kazunori Neves

; de Mattos, Gustavo Henrique Ramalho

; Alcaide, Alexandre

; Rodrigues, Luciano Miller Reis

; Dobashi, Eiffel Tsuyoshi

Revista Brasileira de Ortopedia

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Ago 2020, Volumen 55 Nº 4 Paginas 490 - 496

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Avaliar a acurácia dos métodos de diagnóstico interobservadores do tipo de pisada em atletas corredores utilizando três métodos de avaliação: exame físico, podoscopia e baropodometria comparando com a medida radiográfica dos ângulos de Meary e pitch do calcâneo. Métodos Trata-se de estudo transversal de atletas que praticam corrida. Os critérios de inclusão foram: indivídulos com idade mínima de 18 anos e máxima de 65 anos de ambos os sexos; indivídulos hígidos, sem comorbidades que interfiram no desempenho da corrida; praticantes regulares que realizam corrida ao menos duas vezes na semana; índice de massa corpórea entre 18,5 e 29,99 Kg/m2; aceitação dos termos de consentimento livre e esclarecido (TCLE). Os critérios de não inclusão compreenderam: presença de lesões prévias ou ativas que comprometam a atividade esportiva; cirurgias prévias dos pés; obesidade. Foram selecionados 40 pacientes, sendo 29 (72,5%) do sexo masculino e 11 (27,5%) do sexo feminino cuja média das idades foi de 39 anos (mínimo de 19 anos e máximo de 61 anos). O índice de massa corpórea (IMC) dos 40 pacientes variou de 21,00 a 29,99 Kg/m2 (média de 25,48 Kg/m2 com desvio-padrão de 2,39 Kg/m2 e mediana de 25,50 Kg/m2). Excluímos os que apresentaram valor superior a 29,99 Kg/m2. A frequência de corrida variou de 2 a 5 vezes por semana (média de 3,13 vezes por semana com desvio-padrão de 0,79 vezes por semana e mediana de 3 vezes por semana). Foram realizados exame físico, podoscopia e baropodometria, e sua avaliação foi feita por quatro examinadores; além disso, os resultados foram comparados com a classificação radiográfica do tipo de pisada obtida através da mensuração dos ângulos de Meary e pitch do calcâneo. Resultados A concordância interobservadores destes parâmetros foi verificada pelo índice de concordância de Kappa ponderado, segundo o qual obtivemos uma concordância significante entre os participantes, levando-se em consideração o exame físico, podoscopia e baropodometria e de acordo com o índice Kappa. A concordância foi marginal quando comparados os resultados dos três métodos com a classificação angular radiográfica. Conclusão Obtivemos uma concordância excelente entre os observadores ao considerarmos o exame físico, a podoscopia e a baropodometria para o diagnóstico do tipo pisada em corredores. Porém, quando comparados os resultados obtidos com as medidas radiográficas, a concordância para o diagnóstico do tipo da pisada foi baixa.

Abstract Objective To evaluate the accuracy of interobserver diagnostic methods of the type of footprint among running athletes using three evaluation methods: physical examination, podoscopy, and baropodometry compared with radiographic measurement of Meary angles and calcaneal pitch. Methods This is a cross-sectional study of athletes who practice running. The inclusion criteria were: individuals with minimum age of 18 years and maximum age of 65, male or female, healthy and without comorbidities that interfere with running performance; regular practitioners who run at least twice a week; body mass index between 18.5 and 29.99 Kg/m2; acceptance of the written informed consent form (WICF). The non-inclusion criteria included: presence of previous or active injuries that compromise sports activity; previous foot surgeries; obesity. Forty patients were selected, 29 (72.5%) male and 11 (27.5%) female, whose mean age was 39 years (minimum 19 years and maximum 61 years). The body mass index (BMI) of the 40 patients ranged from 21.00 to 29.99 kg/m2 (mean 25.48 kg/m2 with standard deviation of 2.39 kg/m2 and a median of 25.50 kg/m2). We excluded those with values above 29.99. Running frequency ranged from 2 to 5 times per week (average 3.13 times per week, with standard deviation of 0.79 times per week and median of 3 times per week). Physical examination, podoscopy, and baropodometry were performed, and their evaluation was made by 4 examiners. Additionally, the results were compared with the radiographic classification of the footprint type obtained by measuring the Meary angles and the calcaneal pitch. Results The interobserver agreement of these parameters was verified by the weighted Kappa agreement index, in which we obtained a significant agreement between the participants considering physical examination, podoscopy, and baropodometry, and according to the Kappa index. The agreement was marginal when comparing the results of the three methods with the radiographic angular classification. Conclusion We obtained excellent agreement among observers when considering physical examination, podoscopy, and baropodometry for the diagnosis of the footprint type among runners. However, when comparing the results obtained with the radiographic measurements, the agreement for the diagnosis of footprint type was low.

https://doi.org/10.1055/s-0039-3402464 567 descargas

Outcomes of endovascular treatment of renal arterial stenosis in transplanted kidneys
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Marchini, Giovanni Scala

; Bull, Alexandre Sallum

; Piovesan, Affonso Celso

; Yamaçake, Kleiton Gabriel Ribeiro

; Antonopoulos, Ioannis Michel

; Falci, Renato

; Kanashiro, Hideki

; Ebaid, Gustavo

; Carnevale, Francisco César

; Messi, Gustavo

; Nahas, William Carlos

International braz j urol

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Sep 2019, Volumen 45 Nº 5 Paginas 925 - 931

Resumen: En | Texto: En | PDF: En

ABSTRACT Objective To evaluate the effectiveness and outcomes of endovascular treatment of TRAS with PTA. Materials and Methods We searched our prospectively collected database looking at cases of TRAS between January 2005-December 2011. CCT was the gold-standart for diagnosis of TRAS. Parameters analysed comprised technical aspects, arterial blood pressure variation, and renal function. A minimum follow-up of 24 months was considered. Results Of the 2221 renal transplants performed in the selected period, 22 (0.9%) patients were identified with TRAS. Fourteen (63.6%) were male and mean age was 377±14.8years (12-69). Kidney graft was from deceased donnors in 20 (80%) cases. On doppler evaluation, mean blood flow speed after transplantation, at TRAS diagnosis and after TAP was 210.6±99.5, 417±122.7 and 182.5±81.6mL/sec, respectively (p<0.001). For SBP and DBP, there was a significant difference between between pre-intervention and all post-treatment time points (p<0.001). After 1 month of the procedure, there was stabilization of the Cr level with a significant difference between mean Cr levels along time (p<0.001). After a mean follow-up of 16±4.2 (3-24) months, overall success rate was 100%. Conclusions Endovascular treatment with PTA/stenting is a safe and effective option for managing TRAS, ensuring the functionality of the graft and normalization of blood pressure and renal function.

https://doi.org/10.1590/s1677-5538.ibju.2018.0737 576 descargas

Effects of Curcuma longa rhizome on growth, skin pigmentation, and stress tolerance after transport of Trichogaster labiosa
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Nascimento, Lidiane da Silva

; Reis, Sendy Moreira

; Ferreira, Pollyanna de Moraes França

; Kanashiro, Márcio Yoshiyuki

; Salaro, Ana Lúcia

; Zuanon, Jener Alexandre Sampaio

Revista Brasileira de Zootecnia

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2019, Volumen 48 elocation e20160282

Resumen: En | Texto: En | PDF: En

ABSTRACT We aimed to evaluate the effects of Curcuma longa as growth promoter, skin pigmentation enhancer, and stress reducer in diets of Trichogaster labiosa after transport. We used five diets containing 0.0, 1.0, 5.0, 10.0, and 25.0 g kg−1 of turmeric rhizome powder. We observed quadratic effects of turmeric supplementation for feed intake, weight gain, final length, and specific growth rate. The estimated amount of turmeric that decreased these variables ranged from 15.53 to 16.39 g kg−1. Quadratic effects of supplementation of turmeric for cyan and black dorsal skin coloring indices were observed, with estimated values that increased these variables equal to 15.03 and 17.44 g kg−1, respectively. After fish transport, quadratic effects of turmeric were observed for the cyan and black dorsal skin depigmentation indices, with estimated values that increased these variables equal to 13.29 and 17.04 g kg−1, respectively. These results demonstrate that supplementation with turmeric at levels up to 17 g kg−1 causes further reduction in skin color due to the stress of transport. Thus, Curcuma longa acts neither as a growth promoter nor as a stress reducer for Trichogaster labiosa. Curcuma longa does not improve the orange pattern of skin pigmentation in the strain of T. labiosa orange thick-lipped gourami.

https://doi.org/10.1590/rbz4820160282 1744 descargas

Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests
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Coimbra, Norberto C.

; Paschoalin-Maurin, Tatiana

; Bassi, Gabriel S.

; Kanashiro, Alexandre

; Biagioni, Audrey F.

; Felippotti, Tatiana T.

; Elias-Filho, Daoud H.

; Mendes-Gomes, Joyce

; Cysne-Coimbra, Jade P.

; Almada, Rafael C.

; Lobão-Soares, Bruno

Brazilian Journal of Psychiatry

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Mar 2017, Volumen 39 Nº 1 Paginas 72 - 83

Resumen: En | Texto: En | PDF: En

Objective: To compare prey and snake paradigms performed in complex environments to the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack- and anticipatory anxiety-like behaviors in rodents. Methods: PubMed was reviewed in search of articles focusing on the plus maze test, EPM, and ETM, as well as on defensive behaviors displayed by threatened rodents. In addition, the authors’ research with polygonal arenas and complex labyrinth (designed by the first author for confrontation between snakes and small rodents) was examined. Results: The EPM and ETM tests evoke anxiety/fear-related defensive responses that are pharmacologically validated, whereas the confrontation between rodents and snakes in polygonal arenas with or without shelters or in the complex labyrinth offers ethological conditions for studying more complex defensive behaviors and the effects of anxiolytic and panicolytic drugs. Prey vs. predator paradigms also allow discrimination between non-oriented and oriented escape behavior. Conclusions: Both EPM and ETM simple labyrinths are excellent apparatuses for the study of anxiety- and instinctive fear-related responses, respectively. The confrontation between rodents and snakes in polygonal arenas, however, offers a more ethological environment for addressing both unconditioned and conditioned fear-induced behaviors and the effects of anxiolytic and panicolytic drugs.

https://doi.org/10.1590/1516-4446-2015-1895 2360 descargas

Protein requirement for Trichogaster lalius, blue variety
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Zuanon, Jener Alexandre Sampaio

; Carneiro, Antonio Policarpo Souza

; Nascimento, Lidiane da Silva

; Silva, Donizete Aparecido da

; Pontes, Marcelo Duarte

; Kanashiro, Márcio Yoshiyuki

; Salaro, Ana Lúcia

Revista Brasileira de Zootecnia

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Feb 2013, Volumen 42 Nº 2 Paginas 144 - 147

Resumen: En | Texto: En | PDF: En

The objective of the present study was to evaluate the protein requirement of juvenile Trichogaster lalius, blue variety. The experimental design was of randomised blocks (B1 = initial weight of 1.04±0.05 g and B2 = 1.36±0.02 g), with two replicates within each block and five treatments (230, 270, 310, 350 and 390 g CP/kg diet). The fish were fed to satiation, three times a day for 90 days. The study evaluated: survival rate, weight gain, final length, feed intake, feed conversion ratio, protein efficiency ratio, specific growth rate and condition factor. There was a linear effect of dietary protein levels for protein efficiency ratio, specific growth rate (positive linear effect) and feed conversion ratio (negative linear effect). For weight gain, final length, feed intake and condition factor a quadratic effect of dietary protein levels was observed, with estimated values of 409.8, 366.2, 317.4 and 365.0 g CP/kg diet, to improve their performance parameters. Analysis of growth based on the length of the fish shows that 366.2 g of CP/kg diet meets the protein requirement of juvenile Trichogaster lalius, blue variety.

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In vitro study of antioxidant and scavenger properties of phenolic compounds from Lychnophora species
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Grael, Cristiane F. F.

; Kanashiro, Alexandre

; Kabeya, Luciana M.

; Jordão, Christiane O.

; Takeara, Renata

; Gobbo-Neto, Leonardo

; Polizello, Ana Cristina M.

; Lucisano-Valim, Yara M.

; Lopes, Norberto P.

; Lopes, João Luis C.

Química Nova

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2010, Volumen 33 Nº 4 Paginas 867 - 870

Resumen: En | Texto: En | PDF: En

This paper describes the antioxidant effects of thirteen phenolic compounds isolated from plants of the genus Lychnophora. Two assays were performed to evaluate these effects: a cellular test that measured the luminol-enhanced chemiluminescence produced by neutrophils stimulated with opsonized zymosan and a cell-free test involving horseradish peroxidase-H2O2-luminol. In both assays, the antioxidant activity of the phenolic compounds was dependent on their concentration and chemical structure. Our results suggest that the ability of phenolic compounds from Lychnophora species to scavenge and inhibit the generation of ROS may be a mechanism underlying the anti-inflammatory activity of extracts from Lychnophora spp.

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Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters
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Kanashiro, Alexandre

; Andrade, Daiani C.O.

; Kabeya, Luciana M.

; Turato, Walter M.

; Faccioli, Lucia H.

; Uyemura, Sérgio A.

; Lucisano-Valim, Yara M.

Anais da Academia Brasileira de Ciências

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Mar 2009, Volumen 81 Nº 1 Paginas 67 - 72

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Os flavonóides possuem diversas propriedades farmacológicas, principalmente nas doenças cardiovasculares e inflamatórias. No presente estudo, observamos que a rutina, um conhecido flavonóide glicosilado isolado da Dimorphandra mollis, diminuiu o nível de triglicerídeos plasmáticos em hamsters Golden Syrian hipercolesterolêmicos sem alterar os níveis de colesterol total e colesterol HDL. Além disso, observamos que dietas hipercolesterolêmicas ou suplementadas com rutina não apresentaram efeito imunotóxico, uma vez que nenhuma alteração significativa foi observada nos leucócitos totais, granulócitos e células mononucleares, bem como no grau de neutrófilos em apoptose, quando comparado com animais não tratados. Portanto, a rutina parece ser um modulador seletivo e não tóxico da hipercolesterolemia, o que pode ser promissor para o desenvolvimento de novos fármacos.

Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet-induced hypercholesterolemic Golden Syrian hamsters, but did not change total cholesterol and high-density lipoprotein cholesterol levels. Moreover, high-fat or rutin supplemented diets showed no immunotoxic effects, since no significant changes were observed on total white blood cells, granulocytes and mononuclear cells, as well as on the neutrophil apoptosis degree, when compared to untreated animals. Therefore, rutin seems to be a selective and non-toxic modulator of hypercholesterolemia, which can be promising for the development of new drugs.

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Avaliação bioquímica e ultraestrutural da interação de imunocomplexos de IgG com leucócitos polimorfonucleares: efeito de antioxidantes naturais
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Oliveira, Carlos Alberto de

; Azzolini, Ana Elisa Caleiro Seixas

; Silva, Silvana Chedraoui

; Kanashiro, Alexandre

; Kabeya, Luciana Mariko

; Azevedo, Ana Paula Gomes Braga de

; Gonçalves, Cristiane Fernandes de Freitas

; Corediro, Daniel Sivieri

; Leitão, Denise Pimenta da Silva

; Gaspar, Lorena Rigo

; Souza, Pablo Leonardo Viana de

; Valim, Yara Maria Lucisano

; Mantovani, Bernardo

Eclética Química

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2002, Volumen 27 Nº spe Paginas 273 - 284

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

A produção de espécies reativas de oxigênio (EROs) por leucócitos polimorfonucleares (LPMNs) durante a fagocitose é essencial para a defesa do organismo contra microrganismos invasores. Entretanto, em algumas doenças ocorre a deposição de imunocomplexos, o que leva à produção e liberação excessiva dessas EROs, e conseqüente lesão nos tecidos hospedeiro. Neste trabalho avaliamos o efeito de substâncias naturais (quercetina e 7-aliloxicumarina) sobre a produção de EROs por LPMNs de coelho, estimulados com imunocomplexos de imunoglobulina G (ICIgG), empregando o ensaio de quimioluminescência (QL) dependente de luminol (QL lum) e de QL dependente de lucigenina (QL luc). A interação entre ICIgG e LPMNs, mediada pelo receptor de membrana Fcgama, foi observada por microscopia eletrônica de transmissão, pela intensa marcação dos ICIgG com partículas de ouro coloidal. Os resultados obtidos indicaram que as substâncias analisadas inibiram a QL lum e a QL luc e que tais efeitos não parecem estar relacionados com a inibição da fagocitose, conforme observado no ensaio por microscopia eletrônica.

The generation of reactive oxygen species (EROs) by polymorphonuclear leukocytes (LPMNs) during phagocytosis plays a key role in the organism defense against invading microorganisms. However, in some diseases the immune complexes deposition occurs, that causes an increase in the production and release of EROs. Consequently, the host tissue is damaged. In this work we studied the effect of natural compounds (quercetin and 7-allyloxycoumarin) on EROs generation by rabbit (LPMNs) stimulated with immunecomplexes (IC) of chicken egg albumin (antigen) and class G immuneglobulins (IgG) - ICIgG. The EROs production was measured by chemiluminescence assay (QL) enhanced by luminol (QL lum) or by lucigenin (QL luc). The interaction between ICIgG (conjugated with colloidal gold) e LPMNs, mediated by Fcgamma membrane receptor, was observed by transmission electron microscopy. The results indicated that the studied compounds inhibited QL lum and QL luc. They also suggest that such effects are not related to phagocytosis inhibition, as observed by the electron microscopy assay.

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10.

Tratamento cirúrgico das complicações da anastomose esôfago-visceral cervical
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Corsi, Paulo Roberto

; Kanashiro, Eduardo

; Schiola, Alexandre

; Cretella, Celina Maia

; Gagliardi, Danilo

Revista do Colégio Brasileiro de Cirurgiões

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Oct 2000, Volumen 27 Nº 5 Paginas 293 - 297

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

A anastomose esôfago-visceral cervical apresenta como complicações a fístula e a estenose, que podem necessitar de reintervenção cirúrgica para sua correção. Com o objetivo de avaliar as táticas para abordagem operatória dessas complicações e seus resultados, os autores estudaram retrospectivamente nove pacientes, que demandaram esta conduta, num período de 17 anos. Foram operadas duas fístulas e sete estenoses da anastomose esôfago-visceral cervical, sendo a via de acesso inicial a cervicotomia em todos os pacientes. Em quatro casos, houve necessidade de ampliação para esternotomia mediana total, que facilitou significativamente a reconstrução, porém com mortalidade de 75%. As táticas adotadas foram a reanastomose em cinco casos, a sutura do orifício da fístula em um caso e a plastia em três casos. A ressutura teve mau resultado. As plastias evoluíram satisfatoriamente, e os doentes submetidos a reanastomose sem ésternotomia também evoluíram satisfatoriamente. A plastia da anastomose demonstrou ser uma boa tática para o tratamento da estenose cervical, enquanto a reanastomose parece ter a melhor indicação nas fístulas, devendo-se evitar a esternotomia total mediana.

The esophago-visceral cervical anastomosis presents complications such as fistula and stenosis that may need surgical reintervention for it's correction. The authors, with the objective of evaluating procedures for surgical approach and the results of these complications, have studied retrospectively 9 patients whom demanded this conduct in a 17-year period. Two fistulas and seven esophago-visceral cervical anastomosis stenosis were performed, being cervicotomy the initial access in all patients. In four cases there was a need to enlarge the access, achieved with a total median sternotomy, which made the reconstruction significantly easier, therefore there was 75% mortality. The tactics adopted were reanastomosis in 5 cases, suture of the fistula's orifice in one case, and plasty in three. Ressuturing obtained bad results. The patients subbmited to plasties evoluted satisfactorily and patients submitted to reanastomosis without total median sternotomy also evoluted satisfactorily. Anastomosis plasty proved to be a good tactic for the treatment of cervical stenosis, while reanastomosis seems to be a better indication for treatment of fistulas, being that total median sternotomy is avoided.

3131 descargas Citado 1 vez en SciELO

11.

Validação de questionário para diagnóstico de cefaléia em ambulatório de hospital universitário
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Benseñor, Isabela J. M.

; Lotufo, Paulo A.

; Pereira, Alexandre C.

; Tannuri, Anna Cristina A.

; Issa, Flávia K. K.

; Akashi, Daniela

; Fucciolo, Daniele Q.

; Kakuda, Everton Y. S.

; Kanashiro, Hideki

; Lobato, Maurício L.

; Titan, Sílvia M. O.

; Galvão, Tatiana F. G.

; Martins, Milton de Arruda

Arquivos de Neuro-Psiquiatria

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Sep 1997, Volumen 55 Nº 3A Paginas 364 - 369

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

A cefaléia é sintoma de alta prevalência na população, sendo queixa freqüente na prática clínica. Cursa geralmente com exame físico geral e neurológico normais. A triagem de pacientes com cefaléia facilitaria o atendimento em centros médicos não especializados. No presente estudo utilizou-se um questionário baseado nos critérios da Sociedade Internacional de Cefaléias modificado pelos autores em 204 pacientes de ambulatório do Hospital das Clínicas da FMUSP. Metade destes pacientes foi submetida a consulta clínica. Os resultados do questionário foram então comparados com os resultados da consulta clínica (padrão-ouro). As cefaléias encontradas eram primárias (89,6%) na sua maioria. O questionário demonstrou sensibilidade de 90,2% para detecção das enxaquecas e especificidade de 57,9%, com coeficiente de comparação (kappa) de 0,47, e valor preditivo positivo (VPP) de 65,7% e um valor preditivo negativo (VPN) de 86,8 . A sensibilidade para detecção de cefaléia do tipotensional foi 60,8% e a especificidade foi 87,1% comkappa de 0,49, e VPP de 77,8% e VPN de 75,9. Concluímos que esse questionário pode ser utilizado como um método de triagem para o diagnóstico de cefaléias, podendo ser aplicado por pessoal não médico. Futuramente, ele poderá ser utilizado em estudos populacionais.

Headache is a common complaint with a high prevalence in ambulatory settings. The physical and neurological examinations are frequently normal. The use of questionnaires as a screening method for patients with primary headache could facilitate the diagnosis in non specialized medical centers. In the present study, we used a questionnaire , based on the IHS criteria and modified by the authors, applied to 204 patients from the outpatient clinic of the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Half of the patients were submitted to a clinical interview. We compared the results of the questionnaire with the results of the medical interview (gold standard). Most of the headaches we studied were primary headaches (89.6%). The questionnaire revealed a sensitivity of 90.2% and specificity of 57.9% for migraine detection with a chance corrected agreement {kappa) of 0.47 and a positive predictive (PPV) value of 65.7% and a negative predictive value (NPV) de 86.8%. The sensitivity for tension-type headache detection was 60.8% and the specificity 87.1 % with a kappa value of 0.49 and a PPV of 77.8% and a NPV of 75.9%. We conclude that this questionnaire can be used as a screening method for diagnosing headache and that it can be applied by non-medical personnel. This questionnaire could also be used for population studies.

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Glosario y ayuda para la búsqueda

Ud. puede enriquecer su búsqueda de una forma muy sencilla. Use los índices de búsqueda combinados con los conectores (AND u OR) para especificar su busca.

Por ejemplo, si desea buscar artículos acerca de
casos de dengue en el Brasil en 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

A continuación se muestra la lista completa de los índices de búsqueda que se pueden utilizar:

Cód. del Índice	Elemento
ti	título del articulo
au	autor
kw	palabras clave del artículo
subject	asunto (palabras del título, resumen y palabras clave)
ab	resumen
ta	título abreviado de la revista (ej. Cad. Saúde Pública)
journal_title	título completo de la revista (ej. Cadernos de Saúde Pública)
la	código de idioma de publicación (ej. pt - Portugués, es - Español)
type	tipo de documento
pid	identificador de la publicación
publication_year	año de publicación del artículo
sponsor	financiador
aff_country	código del país de la afiliación del autor
aff_institution	institución de filiación del autor
volume	volumen del artículo
issue	número del artículo
elocation	elocation
doi	número DOI
issn	ISSN de la revista
in	código de la colección SciELO (ej. scl - Brasil, col - Colômbia)
use_license	código de licencia de uso del artículo

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