The ¹H NMR data set of a series of 3-aryl (1,2,4)-oxadiazol-5-carbohydrazide benzylidene derivatives synthesized in our group was analyzed using the chemometric technique of principal component analysis (PCA). Using the original ¹H NMR data PCA allowed identifying some misassignments of the proton aromatic chemical shifts. As a consequence of this multivariate analysis, nuclear Overhauser difference experiments were performed to investigate the ambiguity of other assignments of the ortho and meta aromatic hydrogens for the compound with the bromine substituent. The effect of the 1,2,4-oxadiazol group as an electron acceptor, mainly for the hydrogens 12,13, has been highlighted.

Haletos orgânicos sofrem dimerização redutiva (acoplamento tipo Wurtz) promovida por zinco a temperatura ambiente em meio aquoso. Essas reações são catalisadas por sais de cobre. Este procedimento descreve um método simples e eficiente para o homoacoplamento de brometos benzílicos e alílicos e de iodetos de alquila primários.

Organic halides undergo reductive dimerization (Wurtz-type coupling) promoted by zinc at room temperature in aqueous medium. The reaction yields are strongly enhanced by copper catalysis. This coupling procedure provides an efficient and simple method for the homocoupling of benzylic and allylic bromides and primary alkyl iodides.