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Abstract Objective: The purpose of this study is to evaluate the pharmaceutical interventions (PI) performed in PRM and the factors associated with their acceptance. Method: This is a descriptive and cross-sectional study that analyzed PIs performed on adult patients from two ICUs in Fortaleza, Brazil, in 2019. PIs were analyzed in the categories quantity of drug and pharmacological strategy, using the classification proposed by Sabater et al. The drugs were also classified by the Anatomical, Therapeutic, and Chemical Classification System and by the High Surveillance Drugs (FAV) classification. Results: 305 patients were included, most of them male (55.1 %), elderly (52.8 %) and treated in the surgical ICU (51.4 %). 1,317 PIs were analyzed and 88.0 % were accepted, being to replace one or more drugs (28.0 %), to add one or more drugs (27.7 %) and to change the dose (24.8 %) the most frequent types. The most prevalent therapeutic class was anti-infectives for systemic use (24.1 %) and AVFs were involved in 21.7 % of the PIs. An association was observed between PIs accepted and admission to the clinical ICU (p<0.0001), AVF (p=0.0013), substitution of one or more drugs (p=0.0062) and the class of blood substitutes and perfusion solutions. (p= 0.0187). Conclusions: A high number of PIs were performed and accepted, which reinforces the importance of the pharmacist in the review of medical prescriptions in the ICU.

Resumen Objetivo: El propósito de este estudio es evaluar las intervenciones farmacéuticas (IF) realizadas sobre PRM y los factores asociados a su aceptación. Método: Se trata de un estudio descriptivo y transversal que analizó las IF realizadas a pacientes adultos de dos UCI de Fortaleza, Brasil, en 2019. Las IF se analizaron en las categorías cantidad de fármaco y estrategia farmacológica, utilizando la clasificación propuesta por Sabater et al. Los fármacos se clasificaron además por el Sistema de Clasificación Anatómica, Terapéutica, Química y por la clasificación de Fármacos de Alta Vigilancia (FAV). Resultados: Se incluyeron 305 pacientes, siendo la mayoría del sexo masculino (55,1 %), ancianos (52,8 %) y atendidos en la UCI quirúrgica (51,4 %). Se analizaron 1.317 IF y se aceptaron el 88,0 %, siendo la sustitución de uno o más fármacos (28,0 %) y la adición de uno o más fármacos (27,7 %) las más frecuentes. La clase terapéutica más prevalente fue antiinfeccioso de uso sistémico (24,1 %) y los FAV estuvieron implicados en el 21,7 % de las IF. Se observó asociación entre las IF aceptadas e ingreso en UCI clínica (p<0,0001), FAV (p=0,0013), sustitución de uno o más fármacos (p=0,0062) y la clase sustitutos sanguíneos y soluciones de perfusión (p= 0,0187). Conclusiones: Se realizaron y aceptaron un elevado número de IF, lo que refuerza la importancia del farmacéutico en la revisión de las prescripciones médicas en UCI.

https://doi.org/10.30827/ars.v64i3.27249

Morphological diversity among Brazilian Capsicum peppers
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Almeida, Breno Machado de

; Feitoza, Lidiane de Lima

; Lopes, Ângela Celis de Almeida

; Gomes, Regina Lúcia Ferreira

; Almeida, Rafael da Costa

; Martins, Lívia do Vale

; Silva, Verônica Brito da

Ciência Rural

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2023, Volumen 53 Nº 1 elocation e20210559

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Este trabalho teve como objetivo caracterizar e estimar a diversidade genética em 21 acessos de Capsicum pertencentes ao Banco Ativo de Germoplasma da Universidade Federal do Piauí (BAGC-UFPI), por análises uni e multivariadas. O experimento foi conduzido em telado, utilizando-se o delineamento inteiramente ao acaso, com quatro repetições, sendo uma planta por parcela. Realizou-se análise de variância (ANOVA) e comparação da média para as setes variáveis quantitativas, seguidas do agrupamentos de médias pelo teste Scott-Knott (P < 0,05). A análise dos sete descritores quantitativos e treze qualitativos foi estimada com base na distância de Gower. Posteriormente, foi realizada a análise de componentes principais e o método de agrupamento hierárquico UPGMA. Os resultados caracterizaram e identificaram uma ampla variabilidade genética intra e interespecífica relacionada ao tamanho, cor e formato dos frutos entre os genótipos brasileiros de Capsicum do banco de germoplasma de pimentas BAGC-UFPI. Os descritores utilizados foram eficientes na discriminação dos acessos de pimentas, especialmente para espécies proximamente relacionadas C. frutescens e C. chinense.

ABSTRACT: This research aimed to morphologically characterize and estimate the genetic diversity of 21 Capsicum accessions belonging to the Capsicum Germplasm Active Bank at the Universidade Federal do Piauí (BAGC-UFPI) using uni- and multivariate analysis. The experiment was carried out in a greenhouse, by completely randomized experimental design with four repetitions, with one plant per plot. Analysis of variance (ANOVA) and the comparison of means for seven quantitative variables were performed, followed by clustering the averages by the Scott-Knott test (P < 0.05). The analysis of the seven quantitative and thirteen qualitative descriptors was estimated based on the Gower distance. Later, it was performed the principal component analysis and the UPGMA hierarchical cluster method. Results characterized and identified a wide intra- and interspecific genetic variability related to the fruit size, colors, and shapes among the Brazilian Capsicum genotypes belonging to the BAGC-UFPI. The descriptors used in this research were effective in the discrimination of the pepper accessions, especially the closely related C. frutescens and C. chinense species.

https://doi.org/10.1590/0103-8478cr20210559

Assessing morbidity, mortality, and survival in patients with peritoneal carcinomatosis undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
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VALLEJO, JAIRO SEBASTIÁN ASTUDILLO

; QUEIROZ, FABIO LOPES DE

; LACERDA FILHO, ANTÔNIO

; FRANÇA NETO, PAULO ROCHA

; COSTA, BRENO XAIA MARTINS DA

; PAIVA, RODRIGO ALMEIDA

; GARCIA, SILVÉRIO LEONARDO MACEDO

; SILVA, SERGIO BOTREL

Revista do Colégio Brasileiro de Cirurgiões

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2023, Volumen 50 elocation e20233421

Resumen: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Peritoneal carcinomatosis (PC) indicates advanced stage cancer, which is generally associated with a poor outcome and a 6 to 12 months. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is an option for treating patients with primary PC, such as mesothelioma, or secondary PC, such as colorectal cancer (CRC) or pseudomixoma. Until recently, such patients were deemed untreatable. Objective: The purpose of this study was to assess the results of CRS + HIPEC in patients with PC. Postoperative complications, mortality and survival rates were evaluated according to the diagnosis. Results: Fifty-six patients with PC, undergoing full CRS + HIPEC between October 2004 and January 2020, were enrolled. The mortality rate was 3.8% and the morbidity rate was 61.5%. Complications were significantly higher in proportion to the duration of surgery (p<0.001). The overall survival rates, as shown in the Kaplan-Meyer curve, were respectively 81%, 74% and 53% at 12, 24 and 60 months. Survival rates according to each diagnosis for the same periods were 87%, 82% and 47% in patients with pseudomixoma, and 77%, 72% and 57% in patients with CRC (log-rank 0.371, p=0.543). Conclusion: CRS with HIPEC is an option for pacients with primary or secondary PC. Although complication rates are high, a longer survival rate may be attained compared to those seen in previously published results; in some cases, patients may even be cured.

RESUMO O diagnóstico de carcinomatose peritoneal (CP), indica um estágio avançado do câncer e em geral está associado a um mau prognóstico com sobrevida média variando de 6 a 12 meses. A cirurgia citorredutora (CRS) associada à quimioterapia intraperitoneal hipertérmica (HIPEC) tem sido descrita como uma opção de tratamento para os pacientes portadores de CP primária como nos portadores de mesotelioma, ou secundária como em portadores de cancer colorretal ou pseudomixoma, até recentemente considerados sem possibilidade terapêutica. Objetivo: Avaliar os resultados do tratamento de pacientes portadores de CP submetidos a CRS + HIPEC. Foram analisadas as taxas complicações pós-operatórias, mortalidade e a sobrevida desses pacientes. Resultados: Foram incluídos 56 pacientes com CP, submetidos a c CRS + HIPEC, no período de Outubro 2004 a Janeiro 2020. A taxa de mortalidade foi de 3,8% e taxa de morbidade de 61,5%, sendo a ocorrência de complicações significativamente maior quanto maior o tempo cirúrgico (p<0,001). A sobrevida global pela curva de Kaplan-Meyer foi de 81%, 74% e 53% em 12, 24 e 60 meses respectivamente. Já a sobrevida por diagnóstico nos mesmos períodos foi de 87%, 82%, 47% para os pacientes portadores de pseudomixoma e de 77%, 72% e 57% para pacientes portadores de câncer colorretal (Log -RANK 0,371, p=0,543). Conclusão: A CRS + HIPEC é uma opção de tratamento para pacientes portadores de CP primária ou secundária. Embora com taxa de complicações elevadas, pode proporcionar aumento da sobrevida quando comparado com resultados prévios da literatura e em alguns casos até a cura.

https://doi.org/10.1590/0100-6991e-20233421-en

Panorama das Intervenções Coronárias Percutâneas em Oclusões Totais Crônicas em Centros Participantes do LATAM CTO Registry no Brasil
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Silva, Antonio Carlos Botelho da

; Paula, João Eduardo Tinoco de

; Campos, Carlos M.

; Ribeiro, Marcelo Harada

; Martins Filho, Evandro

; Oliveira, Marcos Danillo Peixoto

; Côrtes, Leandro Assumpção

; Abelin, Aníbal Pereira

; Zukowski, Cleverson Neves

; Martinelli, Gustavo Cervino

; Brito, Fábio Sândoli de

; Muniz, Antônio José

; Cantarelli, Marcelo José de Carvalho

; Andrade, Pedro Beraldo de

; Medeiros, César Rocha

; Falcão, Breno de Alencar Araripe

; Fuchs, Felipe Costa

; Silva, Leonardo Sinnott

; Fattah, Tammuz

; Degrazia, Ramiro Caldas

; Mangione, José Armando

; Bezerra, Cristiano Guedes

; Baradel, Sandra

; Silveira, João Brum

; Ybarra, Luiz Fernando

; Weillenmann, Daniel

; Gottschall, Carlos

; Lemke, Viviana

; Silva, Franciele Rosa da

; Schmidt, Marcia Moura

; Belli, Karlyse Claudino

; Oliveira, Pedro Piccaro de

; Quadros, Alexandre Schaan de

Arquivos Brasileiros de Cardiologia

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2023, Volumen 120 Nº 4 elocation e20210462

Resumen: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Major advances have been seen in techniques and devices for performing percutaneous coronary interventions (PCIs) for chronic total occlusions (CTOs), but there are limited real-world practice data from developing countries. Objectives To report clinical and angiographic characteristics, procedural aspects, and clinical outcomes of CTO PCI performed at dedicated centers in Brazil. Methods Included patients underwent CTO PCI at centers participating in the LATAM CTO Registry, a Latin American multicenter registry dedicated to prospective collection of these data. Inclusion criteria were procedures performed in Brazil, age 18 years or over, and presence of CTO with PCI attempt. CTO was defined as a 100% lesion in an epicardial coronary artery, known or estimated to have lasted at least 3 months. Results Data on 1196 CTO PCIs were included. Procedures were performed primarily for angina control (85%) and/or treatment of moderate/severe ischemia (24%). Technical success rate was 84%, being achieved with antegrade wire approaches in 81% of procedures, antegrade dissection and re-entry in 9%, and retrograde approaches in 10%. In-hospital adverse cardiovascular events occurred in 2.3% of cases, with a mortality rate of 0.75%. Conclusions CTOs can be treated effectively in Brazil by using PCI, with low complication rates. The scientific and technological development observed in this area in the past decade is reflected in the clinical practice of dedicated Brazilian centers.

Resumo Fundamento Tem sido observado um grande avanço nas técnicas e nos dispositivos para a realização de intervenções coronárias percutâneas (ICP) em oclusões totais coronarianas crônicas (OTC), mas existem poucos dados da prática do mundo real em países em desenvolvimento. Objetivos Relatar as características clínicas e angiográficas, os aspectos dos procedimentos e os resultados clínicos da ICP de OTC em centros dedicados a esse procedimento no Brasil. Métodos Os pacientes incluídos foram submetidos à ICP de OTC em centros participantes do LATAM CTO Registry, um registro multicêntrico latino-americano dedicado à coleta prospectiva desses dados. Os critérios de inclusão foram procedimentos realizados no Brasil, idade acima de 18 anos e presença de OTC com tentativa de ICP. A definição de OTC foi lesão de 100% em uma artéria coronária epicárdica, conhecida ou estimada como tendo pelo menos 3 meses de evolução. Resultados Foram incluídos dados de 1.196 ICPs de OTC. Os procedimentos foram realizados principalmente para controle da angina (85%) e/ou tratamento de uma grande área isquêmica (24%). A taxa de sucesso técnico foi de 84% e foi alcançada com técnicas de fios anterógrados em 81%, dissecção/reentrada anterógrada em 9% e retrógrada em 10% dos procedimentos. Os eventos cardiovasculares adversos intra-hospitalares ocorreram em 2,3% dos casos, sendo a mortalidade de 0,75%. Conclusões As OTC podem ser tratadas no Brasil por intervenção coronária percutânea de forma efetiva e com baixas taxas de complicações. O desenvolvimento científico e tecnológico observado nessa área na última década reflete-se na prática clínica de centros brasileiros dedicados a essa técnica.

https://doi.org/10.36660/abc.20210462

Posicionamento sobre Doença Isquêmica do Coração – A Mulher no Centro do Cuidado – 2023
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Oliveira, Gláucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Rassi, Daniela do Carmo

; Bragança, Érika Olivier Vilela

; Moura, Lidia Zytynski

; Arrais, Magaly

; Campos, Milena dos Santos Barros

; Lemke, Viviana Guzzo

; Avila, Walkiria Samuel

; Lucena, Alexandre Jorge Gomes de

; Almeida, André Luiz Cerqueira de

; Brandão, Andréa Araujo

; Ferreira, Andrea Dumsch de Aragon

; Biolo, Andreia

; Macedo, Ariane Vieira Scarlatelli

; Falcão, Breno de Alencar Araripe

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Marques-Santos, Celi

; Freire, Claudia Maria Vilas

; Pellegrini, Denise

; Alexandre, Elizabeth Regina Giunco

; Braga, Fabiana Goulart Marcondes

; Oliveira, Fabiana Michelle Feitosa de

; Cintra, Fatima Dumas

; Costa, Isabela Bispo Santos da Silva

; Silva, José Sérgio Nascimento

; Carreira, Lara Terra F.

; Magalhães, Lucelia Batista Neves Cunha

; Matos, Luciana Diniz Nagem Janot de

; Assad, Marcelo Heitor Vieira

; Barbosa, Marcia M.

; Silva, Marconi Gomes da

; Rivera, Maria Alayde Mendonça

; Izar, Maria Cristina de Oliveira

; Costa, Maria Elizabeth Navegantes Caetano

; Paiva, Maria Sanali Moura de Oliveira

; Castro, Marildes Luiza de

; Uellendahl, Marly

; Oliveira Junior, Mucio Tavares de

; Souza, Olga Ferreira de

; Costa, Ricardo Alves da

; Coutinho, Ricardo Quental

; Silva, Sheyla Cristina Tonheiro Ferro da

; Martins, Sílvia Marinho

; Brandão, Simone Cristina Soares

; Buglia, Susimeire

; Barbosa, Tatiana Maia Jorge de Ulhôa

; Nascimento, Thais Aguiar do

; Vieira, Thais

; Campagnucci, Valquíria Pelisser

; Chagas, Antonio Carlos Palandri

Arquivos Brasileiros de Cardiologia

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2023, Volumen 120 Nº 7 elocation e20230303

Resumen: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230303

Influence of nutritional management prior to adaptation to a feedlot diet on ruminal microbiota of Nellore cattle
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Pinto, Ana Carolina Janssen

; Bertoldi, Gustavo Perina

; Felizari, Luana Doretto

; Demartini, Breno Leite

; Dias, Evandro Fernando Ferreira

; Squizatti, Mariana Martins

; Silvestre, Antonio Marcos

; Perna Junior, Flavio

; Mesquita, Lígia Garcia

; Souza, Johnny Maciel

; Rodrigues, Paulo Henrique Mazza

; Cruz, Gustavo D.

; Millen, Danilo Domingues

Revista Brasileira de Zootecnia

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2023, Volumen 52 elocation e20210229

Resumen: En | Texto: En | PDF: En

ABSTRACT The objective of this study was to evaluate the effect of either a limited forage intake or concentrate supplementation prior to the adaptation to high-concentrate diets on dry matter intake, ruminal pH, bacteria, and protozoa of Nellore cattle. The experiment was designed as a two 3×3 Latin square, and six cannulated Nellore steers were used. Each experimental period was composed by three feeding phases: pre-adaptation (14 days), adaptation (12 days), and finishing (seven days) diet, in a total of 33 days per period. The steers were assigned to one of three pre-adaptation dietary treatments: control (Tifton hay fed ad libitum + mineral supplement), restriction (Tifton hay fed at 1.4% of BW + mineral supplement), and concentrate (Tifton hay fed ad libitum + 0.5% of BW of a mix of concentrate feedstuffs and mineral supplement). The adaptation period consisted of two adaptation diets, which contained 72 and 79% concentrate for six days each. The finishing diet contained 86% concentrate. During the pre-adaptation phase, restricted cattle had higher pH than concentrate-fed cattle. There was a reduction in M. elsdenii relative population in cattle from either restriction or concentrate groups. During adaptation and finishing phases, cattle from concentrate group had smaller F. succinogenes populations compared with the control group. The previous nutritional backgrounds impact ruminal microbiota during adaptation and finishing phases without causing any negative effect on ruminal pH. Feeding concentrate prior to the adaptation positively impacted the transition to high-concentrate diets and promoted increased dry matter intake.

https://doi.org/10.37496/rbz5220210229

Polyp detection in the cecum and ascending colon by dye based chromoendoscopy - Is its routine use justified?
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PAIVA, RODRIGO ALMEIDA

; QUEIROZ, FABIO LOPES

; FRANÇA NETO, PAULO ROCHA

; COSTA, BRENO XAIA MARTINS DA

; CARDOSO, LUCAS ALVES BESSA

; ESTRADA, DANIEL MAURICIO LONDOÑO

; MOTA, FELIPE FERREIRA DA

; LACERDA FILHO, ANTÔNIO

Revista do Colégio Brasileiro de Cirurgiões

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2023, Volumen 50 elocation e20233562

Resumen: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Introduction: colonoscopy is the best method for detecting polyps, with a reduction in colorectal cancer mortality of 29% and reaching 47% for distal tumors. However, it fails to demonstrate a significant reduction in proximal colon cancer mortality, and is the most common segment with interval neoplasm. The present study aimed to evaluate the impact on detection of polyps of a second sequential evaluation of cecum and ascending colon, with or without the use of indigo carmine chromoendoscopy. Methods: prospective, non-randomized clinical trial. Patients were divided into two groups. The first (G1) underwent a routine colonoscopy, followed by a second endoscopy assessment of ascending colon and cecum. The second group (G2) underwent a routine colonoscopy, followed by a second assessment of the ascending colon and cecum with indigo carmine chromoendoscopy. Results: In total, 203 patients were analyzed, 101 in the G1 and 102 in the G2. Newer polyps were identified in both groups after the second assessment with a significantly higher number of polyps detected in the patients in the G2 (p=0.0001). The number of patients who had at least one polyp in the two endoscopic assessments was significantly higher in the G2 (53 or 52% vs 27 or 26.7%, p=0.0002). In the second endoscopic assessment, the number of polyps found was also significantly higher in the G2 (50 or 76.9%) compared to the G1 (15 or 23.1%), p<0.0001. Conclusions: the second assessment with dye-based chromoendoscopy increases the detection of polyps in the ascending colon and cecum.

RESUMO Introdução: a colonoscopia é o melhor método para detecção de pólipos, com redução da mortalidade por câncer colorretal de 29% e chegando até 47% para tumores distais. No entanto, existe falha em demonstrar redução significativa na mortalidade no cólon proximal sendo o segmento mais comum de neoplasia de intervalo. O presente estudo avaliou o impacto na detecção de pólipos em uma segunda avaliação sequencial do ceco e cólon ascendente, com ou sem o uso de cromoendoscopia com Indigo carmim. Métodos: estudo prospectivo, não randomizado. Os pacientes foram divididos em dois grupos. O primeiro (G1) foi submetido à colonoscopia de rotina, seguida de segunda avaliação endoscópica do cólon ascendente e ceco. O segundo grupo (G2) foi submetido à colonoscopia de rotina, seguida de segunda avaliação do cólon ascendente e ceco com cromoendoscopia com índigo carmim. Resultados: no total, foram analisados 203 pacientes, sendo 101 do G1 e 102 do G2. Novos pólipos foram identificados em ambos os grupos após a segunda avaliação com número significativamente maior de pólipos detectados nos pacientes do G2 (p=0,0001). O número de pacientes que apresentaram pelo menos um pólipo nas duas avaliações endoscópicas foi significativamente maior no G2 (53 ou 52% vs 27 ou 26,7%, p=0,0002). Na segunda avaliação endoscópica, o número de pólipos encontrados também foi significativamente maior no G2 (50 ou 76,9%) em relação ao G1 (15 ou 23,1%), p<0,000. Conclusão: a segunda avaliação com cromoendoscopia com índigo carmim aumenta a detecção de pólipos no cólon ascendente e no ceco.

https://doi.org/10.1590/0100-6991e-20233562-en

2-(Pyridin-4yl)benzothiazole and Its Benzimidazole-Analogue: Biophysical and in silico Studies on Their Interaction with Urease and in vitro Anti-Helicobacter pylori Activities
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Pereira, Camila P.

; Lyra, Ana C. F. de

; Oliveira, Breno G. F.

; Nascimento, Igor J. S.

; Silva-Júnior, Edeildo F. da

; Aquino, Thiago M. de

; Sisto, Francesca

; Figueiredo, Isis M.

; Martins, Felipe T.

; Modolo, Luzia V.

; Santos, Josué C. C.

; Fátima, Ângelo de

Journal of the Brazilian Chemical Society

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Sep 2022, Volumen 33 Nº 9 Paginas 1041 - 1057

Resumen: En | Texto: En | PDF: En

In this study, the interaction between benzothiazole (BTA, concentration of a drug required for 50% inhibition in vitro (IC50) = 0.77 mM) and benzimidazole (BIA, IC50 = 2.14 mM) with urease was quantitatively assessed, using UV-Vis, molecular fluorescence, and circular dichroism. The results showed that both compounds interact with urease by a static fluorescence quenching mechanism with a non-fluorescent complex formation. The main forces responsible for stabilizing the supramolecular complex between BTA and urease were hydrophobic while, for BIA, van der Waals interactions and hydrogen bonds were the main ones. Urease conformation changes due to the interaction process were analyzed by circular dichroism and synchronous fluorescence. Besides, a competitive assay with substrate and inhibitors was used to evaluate the preferential urease site of interaction with BTA and BIA. Our experimental and theoretical studies supported that both, BTA and BIA, are mixed-inhibitors of ureases with a slight preference to the active site of such enzymes. Finally, both BTA and BIA showed to possess anti-Helicobacter pylori (one reference strain and six clinical isolates) activity, presenting minimal inhibitory concentration (MIC) values ranging from 38-150 and 20-164 µM, respectively. The urease inhibitors omeprazole and hydroxyurea showed MIC values in the range of 46-185 µM and 1683-> 3366 µM, respectively.

https://doi.org/10.21577/0103-5053.20220020

Growth, productivity and viability of irrigation in cassava crop in the Alagoas Coastal Plateaus
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Silva, Ricardo Barros

; Teodoro, Iêdo

; Souza, José Leonaldo de

; Magalhães, Ivomberg Dourado

; Morais, Marcos Antônio Ferreira de

; Teodoro, Iêdo Peroba de Oliveira

; Silva, Julianna Catonio da

; Lopes, Joyce Herculano

; Santos, Jonathan Tenório

; Almeida, Breno Vasconcelos de Lyra Rolim de

; Ramos, Pedro Felipe da Silva

; Gois, Pedro Vinícius Souza

; Cordeiro, Levi Rocha

; Santos Júnior, José Carlos dos

; Martins, Gleica Maria Correia

; Santos, Wellington Manoel dos

Ciência Rural

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2022, Volumen 52 Nº 4 elocation e20210145

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Esta pesquisa avaliou os efeitos da irrigação no crescimento e na produtividade da mandioca irrigada nos Tabuleiros Costeiros alagoanos. O plantio foi feito em blocos casualizados, com seis tratamentos e quatro repetições. Os tratamentos foram níveis de irrigação em função da evapotranspiração da cultura - ETC (L0 = 0% (sequeiro), L1 = 40%, L2 = 80%, L3 = 120%, L4 = 160% e L5 = 200% da ETC). A lâmina total foi definida como o total da irrigação mais a chuva efetiva. A evapotranspiração anual da cultura da mandioca nos Tabuleiros Costeiros de Alagoas é 1.030 mm. O crescimento das plantas aumentou significativamente com a irrigação e os valores máximos das seguintes variáveis são: índice de área foliar = 7,6; comprimento de raízes comerciais = 49 cm; produtividades (física e econômica) máximas de raízes comerciais = 94 t ha-1 e biomassa total = 149 t ha-1 e o índice de colheita = 0,66, todos obtidos com lâminas de irrigação totais (chuva efetiva mais irrigação) entre 817 e 963 mm. Por fim, ratifica-se que entender o crescimento, as produtividades agrícola e economicamente viáveis da mandioca irrigada, é fator indispensável para se fazer um bom manejo da cultura, principalmente, em regiões com irregularidade de chuvas como o nordeste brasileiro.

ABSTRACT: This research evaluated the effects of the irrigation on growth and productivity of irrigated cassava in the Coastal Plateaus of Alagoas. The planting was done in randomized blocks, with six treatments and four replications. The treatments were irrigation levels in function of crop evapotranspiration - ETC (L0 = 0% (rainfed), L1 = 40%, L2 = 80%, L3 = 120%, L4 = 160% and L5 = 200% of ETC). The total water applied was defined as the total irrigation plus the effective rain. The annual evapotranspiration of the cassava plantations in the Costal Plateaus of Alagoas, was 1,030 mm. Plant growth increased significantly with irrigation and the maximum values of the following variables are: leaf area index = 7.6, length of commercial roots = 49 cm, maximum productivity (physical and economic) of commercial roots = 94 Mg ha-1 and total biomass = 149 Mg ha-1 and the harvest index = 0.66, all obtained with total irrigation depths (effective rain plus irrigation) between 817 and 963 mm. Finally, it is ratified that understanding the growth, the agricultural and economically viable productivity of irrigated cassava, is an indispensable factor for good management of the crop, especially in regions with irregular rainfall such as the Northeast of Brazil.

https://doi.org/10.1590/0103-8478cr20210145 67 descargas

10.

Hematological and biochemical parameters of premature kids of goats subjected to different dexamethasone protocols
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Narciso, Luis Gustavo

; Alcindo, Jefferson Ferreira

; Bovino, Fernanda

; Trevizan, Juliane Teramachi

; Vieira, Dielson da Silva

; Almeida, Breno Fernando Martins de

; Bosco, Anelise Maria

; Feitosa, Francisco Leydson Formiga

Ciência Rural

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2022, Volumen 52 Nº 6 elocation e20210278

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: A corticoterapia tem sido empregada em ruminantes com o objetivo de permitir a maturação pulmonar e o nascimento de filhotes prematuros. Entretanto, ao se considerar análises laboratoriais desses animais, pouquíssimos dados estão disponíveis quanto aos padrões hematológicos e bioquímicos, especialmente em caprinos prematuros, e tampouco se sabe sobre os efeitos da corticoterapia sobre parâmetros hematológicos e bioquímicos nesses animais. Nesse contexto, objetivou-se avaliar os parâmetros hematológicos e bioquímicos das primeiras horas de vida de cabritos prematuros provenientes de cabras que utilizaram diferentes protocolos de dexametasona. Para tal, as cabras foram divididas em três grupos: grupo I, cabras que receberam 20 mg de dexametasona aos 139 dias de gestação; grupo II, 2 mg de dexametasona do 133° ao 136° dia de gestação, 4 mg do 137° ao 139° e 20 mg no 140° dia; grupo III, 16 mg de dexametasona a partir do 139° dia, com doses repetidas a cada 12 horas até a cirurgia eletiva; e grupo IV, cabras que receberam 4, 8, 16 e 20 mg de dexametasona no 137°, 138°, 139° e 140° dias de gestação, respectivamente. As amostras sanguíneas dos cabritos foram obtidas ao nascimento (T0h), 1 (T1h), 12 (T12h), 24 (T24h) e 48 horas (T48h) de vida para avaliação do hemograma e bioquímica sérica de ureia, creatinina, proteína total (PT) e gamaglutamiltransferase (GGT). Os teores de PT e atividade de GGT foram menores ao nascimento em todos os grupos, elevando-se após ingestão do colostro. Os valores de creatinina em todos os grupos experimentais não diferiram entre T0h e T1H, entretanto, diminuíram nos momentos subsequentes. Com exceção do grupo I, as concentrações de ureia foram maiores no T48h em comparação com o T1h. Os valores de hemácias, hemoglobina, hematócrito e volume corpuscular médio diminuíram ao longo do tempo, enquanto a concentração de hemoglobina corpuscular média aumentou ao longo do tempo. A contagem leucocitária total se comportou de maneira distinta nos diferentes grupos experimentais, demonstrado ser influenciada pelos teores de dexametasona principalmente em decorrência da alteração nas contagens de neutrófilos segmentados e linfócitos. Conclui-se que alterações significativas dos parâmetros hematológicos e bioquímicos ocorrem nas primeiras horas de vida de cabritos prematuros e o tratamento de cabras com dexametasona também pode afetar tais parâmetros de forma dependente da dose.

ABSTRACT: Corticosteroid therapy has been used for ruminants to allow lung maturation and the birth of premature babies. However, when considering laboratory analyses of these animals, very little data is available regarding hematological and biochemical patterns, especially for premature goats, and the effects of corticotherapy on these parameters are unknown. In this context, the objective of this study was to evaluate the hematological and biochemical parameters during the first hours of life of premature kids from goats subjected to different dexamethasone protocols. For this, the goats were divided into four groups: group I, goats that received 20 mg of dexamethasone at 139 days of gestation; group II, 2 mg of dexamethasone from the 133rd to 136th day of gestation, 4 mg from the 137th to 139th, and 20 mg on the 140th; group III, 16 mg of dexamethasone from the 139th day, with repeated doses every 12 h until elective surgery; and group IV, goats that received 4, 8, 16, and 20 mg of dexamethasone at 137, 138, 139, and 140 days of gestation, respectively. Blood samples were obtained at birth (T0h) and after 1 (T1h), 12 (T12h), 24 (T24h), and 48 h (T48h) of life for hemogram and serum biochemistry assessment of urea, creatinine, total protein (PT), and gamma-glutamyltransferase (GGT). PT levels and GGT activity were lower at birth in all groups and rose after colostrum ingestion. The creatinine values for all the experimental groups did not differ between T0h and T1h; however, they decreased in the subsequent moments. Except for group I, urea concentrations were higher at T48h than at T1h. The red blood cell, hemoglobin, hematocrit, and mean corpuscular hemoglobin counts decreased over time. The total leukocyte count behaved differently in different experimental groups, and was influenced by the levels of dexamethasone, mainly due to the change in the counts of segmented neutrophils and lymphocytes. It was concluded that significant changes in the hematological and biochemical parameters occur in the first hours of life of premature kids, and that the treatment of goats with dexamethasone can affect these parameters in a dose-dependent manner.

https://doi.org/10.1590/0103-8478cr20210278

11.

Karyotype polymorphism of GC-rich constitutive heterochromatin in Capsicum L. pepper accessions
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Almeida, Breno Machado de

; Martins, Lívia do Vale

; Lopes, Ângela Celis de Almeida

; Gomes, Regina Lúcia Ferreira

; Valente, Sérgio Emílio dos Santos

; Peron, Ana Paula

; Silva, Verônica Brito da

; Feitoza, Lidiane de Lima

Crop Breeding and Applied Biotechnology

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2022, Volumen 22 Nº 1 elocation e38642113

Resumen: En | Texto: En | PDF: En

Abstract Capsicum is represented by peppers and sweet peppers and comprises a group with remarkable genetic variability. Different cultivated Capsicum peppers of Brazil were evaluated by using CMA3 and DAPI specific fluorochromes. There was high polymorphism of highly GC-rich CMA heterochromatic bands among the analyzed species, ranging from six (BAGC 114; C. annuum) to 26 blocks (BAGC 81; C. baccatum). Heterochromatin percentage ranged from 3.14% (BAGC 114; C. annuum) to 8.72% (BAGC 81; C. baccatum), corroborating the variation in the number of heterochromatic bands, particularly those distributed in the terminal and subterminal regions of the chromosomes. The information reported in this paper supports the cytogenetic characterization of the domesticated peppers accessions belonging to the Capsicum Germplasm Active Bank of the Federal University of Piauí (BAGC-UFPI). Moreover, the present data helped to better understand the karyotype features of peppers and provide additional information that could contribute to the improvement and maintenance of Capsicum genetic breeding programs.

https://doi.org/10.1590/1984-70332022v22n1a03

12.

Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
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Chaves, Ian de Meira

; Zicker, Marina Campos

; Laranjeira, Alice de Oliveira

; Silveira, Ana Letícia Malheiros

; Aguiar, Daniele Cristina de

; Barrioni, Breno Rocha

; Ferreira, Adaliene Versiani de Matos

; Teixeira, Mauro Martins

; Silva, Tarcília Aparecida da

; Souza, Daniele da Glória de

; Madeira, Mila Fernandes Moreira

Journal of Applied Oral Science

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2022, Volumen 30 elocation e20220238

Resumen: En | Texto: En | PDF: En

Abstract Periodontal diseases (PD) are inflammatory conditions that affect the teeth supporting tissues. Increased body fat tissues may contribute to activation of the systemic inflammatory response, leading to comorbidities. Some studies have shown that individuals with obesity present higher incidence of PD than eutrophics. Objective: To investigate the impact of obesity on periodontal tissues and oral microbiota in mice. Methodology: Two obesity mice models were performed, one using 12 weeks of the dietary protocol with a high-fat (HF) diet in C57BL/6 mice and the other using leptin receptor-deficient mice (db/db-/-), which became spontaneously obese. After euthanasia, a DNA-DNA hybridization technique was employed to evaluate the microbiota composition and topical application of chlorhexidine (CHX), an antiseptic, was used to investigate the impact of the oral microbiota on the alveolar bone regarding obesity. Results: Increased adipose tissue may induce alveolar bone loss, neutrophil recruitment, and changes in the oral biofilm, similar to that observed in an experimental model of PD. Topical application of CHX impaired bone changes. Conclusion: Obesity may induce changes in the oral microbiota and neutrophil recruitment, which are associated with alveolar bone loss.

https://doi.org/10.1590/1678-7757-2022-0238

13.

Water availability and substrate in the emergency and initial development of Bauhinia scandens L.
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Jeromini, Tatiane Sanches

; Silva, Givanildo Zildo da

; Martins, Cibele Chalita

; Neves, Breno Rosa

Revista Ceres

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Abr 2021, Volumen 68 Nº 2 Paginas 143 - 148

Resumen: En | Texto: En | PDF: En

ABSTRACT Bauhinia scandens is an ornamental plant and it has anti-tumor properties. The demand for seedlings of this species makes it necessary to know about the germinative behavior of seeds and the initial growth of seedlings. The objective of the present work was to determine the type of substrate and moistening conditions that are more favorable to the emergence and development of seedlings of B. scandens. B. scandens seeds were disposed on three substrates: sand, vermiculite, and commercial substrate, maintained at four levels of moistening 25, 50, 75, and 100% of the water holding capacity of the substrate and kept in a greenhouse for 60 days. The following parameters were evaluated: emergence, speed index, average time, number of leaves, length of aerial part and root, diameter of neck, fresh and dry mass of aerial part and root. The analysis of variance was performed in a completely randomized design, in a 3 X 4 factorial scheme, with four replications of 25 seeds. The sowing of B. scandens should be carried out initially in vermiculite with a holding capacity of 100% until the establishment of the seedling emergence and then transplanted to commercial substrate keeping between 50 and 75% holding capacity.

https://doi.org/10.1590/0034-737x202168020008 136 descargas

14.

Prevalence and Associated Factors of Dental Trauma in Six-Year-Old School-Children
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Malinverni, Breno

; Lunardelli, Abelardo Nunes

; Lunardelli, Sandra Espíndola

; Martins, Luiz Gustavo Teixeira

; Nunes, Rodrigo Dias

; Traebert, Eliane

; Traebert, Jefferson

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2021, Volumen 21 elocation e0171

Resumen: En | Texto: En | PDF: En

ABSTRACT Objective: To estimate the prevalence and associated factors of dental trauma in 6-year-old school children in the city of Palhoça, Brazil. Material and Methods: Cross-sectional study nested in a cohort study. It involved a representative sample of school children born in 2009, residing in the municipality and regularly enrolled in public and private schools (n = 1,102). Clinical data were obtained through oral exams. To evaluate the incisal overjet, the distance in millimeters was measured horizontally from the labial surface of the lower central incisor to the labial surface of the upper incisor. Bivariate analyses were performed using the Chi-square test, with a p-value <0.05 considered statistically significant. Multivariate analyses using Poisson Regression were performed to identify independent associations between the prevalence and the independent variables studied. Results: Prevalence of dental trauma was 4.2% (95% CI 3.0-5.4). Dental trauma was statistically associated with studying in a private school (PR = 1.03; 95% CI 1.01-1.06) (p=0.016) and with inadequate lip coverage (PR = 1.08; 95% CI 1.01-1.14) (p=0.016). Conclusion: The prevalence of 4.2% of dental trauma in six-year-old children, associated with inadequate and greater lip coverage in children from private schools should be taken into account, since most teeth at this stage are newly erupted.

https://doi.org/10.1590/pboci.2021.033 206 descargas

15.

Epidemiology of canine visceral leishmaniasis in a vulnerable region in Brazil
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Silva, Douglas Aparecido da

; Bonatto, Natália Camila Minucci

; Venturin, Gabriela Lovizutto

; Melo, Larissa Martins

; Oliveira, Paula Lima de

; Costa, Letícia Ramos

; Bosculo, Maria Rachel Melo

; Barros, Luiz Daniel de

; Lima, Valéria Marçal Felix de

; Almeida, Breno Fernando Martins de

Revista Brasileira de Parasitologia Veterinária

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2021, Volumen 30 Nº 3 elocation e009921

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A leishmaniose visceral (LV) é uma zoonose negligenciada e endêmica presente em todas as regiões do Brasil, mas mesmo assim poucos estudos têm objetivado a detecção inicial da doença. O município de Ourinhos - SP é uma área não receptiva, silenciosa e vulnerável à LV, não havendo até o momento estudos que tenham investigado a soroprevalência no município. Nesse sentido, o presente estudo objetivou determinar a soroprevalência da LV canina em Ourinhos-SP, bem como associar a presença de fatores de risco. Amostras sanguíneas de 604 cães foram obtidas juntamente com a aplicação de questionário socioeconômico, características ambientais e dos animais e conhecimento sobre a doença. As amostras foram submetidas à sorologia por ELISA e novas amostras coletadas de cães reagentes ou suspeitos foram analisadas por método parasitológico direto, hemograma e PCR. Nenhum animal foi considerado positivo na combinação de testes direto e indireto, e as respostas dos tutores indicaram pouco conhecimento sobre a leishmaniose, sendo muitas vezes confundida com outras doenças transmitidas por artrópodes. Dessa forma, de acordo com os métodos propostos, a presença de leishmaniose canina, na cidade de Ourinhos, não foi confirmada. Por isso campanhas de educação em saúde sobre a doença deveriam ser realizadas.

Abstract Visceral leishmaniasis (VL) is a neglected and endemic zoonosis that occurs throughout Brazil; nevertheless, few studies have focused on the early detection of the disease. The municipality of Ourinhos is a non-receptive, silent and vulnerable area for VL, where the seroprevalence of this disease has so far not been investigated. The present study aimed to determine the seroprevalence of canine VL in Ourinhos-SP, and to identify the presence of risk factors. Blood samples were obtained from 604 dogs during a rabies vaccination campaign together with application of a socioeconomic questionnaire, environmental and animal characteristics and tutor's knowledge about the disease. The samples were subjected to indirect ELISA and new samples were collected from reactive and suspect animals, including whole blood and lymph node aspiration evaluated by parasitological method, complete blood count and PCR. No animal was diagnosed as positive based on the combination of direct and indirect tests and the tutors' answers indicated little knowledge about leishmaniasis, being often confused with other diseases transmitted by arthropods; hence, according to the proposed methods, the presence of canine leishmaniasis in the city of Ourinhos was not confirmed and health education campaigns about the disease should be carried out.

https://doi.org/10.1590/s1984-29612021075 109 descargas

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