Isoniazid (INH), one of the most important drugs used in antituberculosis (anti-TB) treatment, is also the major drug involved in hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, such as NAT2, CYP2E1, GSTM1 and GSTT1, that code for drug-metabolising enzymes. Our goal was to examine the polymorphisms in these enzymes as susceptibility factors to anti-TB drug-induced hepatitis in Brazilian individuals. In a case-control design, 167 unrelated active tuberculosis patients from the University Hospital of the Federal University of Rio de Janeiro, Brazil, were enrolled in this study. Patients with a history of anti-TB drug-induced acute hepatitis (cases with an increase to 3 times the upper limit of normal serum transaminases and symptoms of hepatitis) and patients with no evidence of anti-TB hepatic side effects (controls) were genotyped for NAT2, CYP2E1, GSTM1 and GSTT1 polymorphisms. Slow acetylators had a higher incidence of hepatitis than intermediate/rapid acetylators [22% (18/82) vs. 9.8% (6/61), odds ratio (OR), 2.86, 95% confidence interval (CI), 1.06-7.68, p = 0.04). Logistic regression showed that slow acetylation status was the only independent risk factor (OR 3.59, 95% CI, 2.53-4.64, p = 0.02) for the occurrence of anti-TB drug-induced hepatitis during anti-TB treatment with INH-containing schemes in Brazilian individuals.

PROBLEM:The decrease or loss of functional capacity is a process that can be aggravated by diseases. OBJECTIVE: to evaluate the capacity of the aged to perform activities of daily living and instrumental activities of daily living. METHOD: a quantitative descriptive research, in day hospital of old in Anápolis-GO. The 30 aged participated and answered 3 instruments: questionnaire, Lawton Scale and Functional Independence Measure. RESULTS: In the Activities of Daily Living had been observed more dependency for use of ladders, memory, locomotion, control of urine, problem solving, social interaction and get dress below the waist. For the Instrumental Activities of Daily Living had partial dependency housekeeping and shopping, and full-pending use the phone and take care of finances. CONCLUSION: wich this results it is possible to infer that strategies that seek to the improvement of the aged's functionality can favor the aging autonomous, independent and free from offences to the health.

PROBLEMA: A diminuição ou perda da capacidade funcional é um processo que pode ser agravado por doenças. OBJETIVO: avaliar a capacidade de idosos de desempenhar as atividades de vida diária e atividades instrumentais de vida diária. MÉTODO: Pesquisa de abordagem quantitativa, descritiva realizada em hospital dia do idoso de Anápolis-GO. Participaram 30 idosos que responderam três instrumentos: questionário, Escala de Lawton e Medida de Independência Funcional. Para análise dos dados foi utilizada estatística descritiva. RESULTADOS: Nas Atividades de Vida Diária observaram-se maior dependência para uso de escadas, memória, locomoção, controle de urina, resolução de problemas, interação social e vestir-se abaixo da cintura. Para as Atividades Instrumentais de Vida Diária dependência parcial para arrumação da casa e em fazer compras, e dependência completa usar o telefone e cuidar das finanças. CONCLUSÃO: Diante dos resultados é possível inferir que estratégias que visem à melhoria da funcionalidade do idoso podem favorecer o envelhecimento autônomo, independente e livre de agravos à saúde.