Búsqueda | SciELO

This work describes a green synthesis, the characterization, and biological evaluation of silver nanoparticles (AgNPs). The AgNPs suspension was synthesized using aqueous leaf extract of Eucalyptus grandis, which presented a characteristic band at 407 nm in the UV-Vis spectrum. The AgNPs presented a spherical shape and size of 9.7 ± 0.3 nm. The nanoparticles were stable over a month, indicating that E. grandis’ extract is suitable for their preparation and stabilization. The X-ray analysis showed that the crystallinity of AgNPs corresponded to the centered face phase of silver. The antibacterial and leishmanicidal activities of AgNPs were evaluated. The AgNPs presented antibacterial activity on the Gram-negative bacteria Escherichia coli at 53.9 µg mL-1. The leishmanicidal activity evaluation against promastigote forms of Leishmania infantum, Leishmania amazonensis, and Leishmania braziliensis showed that the biological response is dependent on the volume of AgNP suspension. It was demonstrated that L. infantum was more sensitive to the nanoparticle’s treatment than L. amazonensis and L. braziliensis. The treatment of L infantum promastigotes with 150 µL of AgNP suspension reduced parasite growth by 67.9%, a result which was similar to the treatment with 1 (66.7%) or 2 µL (70.6%) of amphotericin B used as a positive control.

https://doi.org/10.21577/0103-5053.20220126

Multidisciplinary Scientific Cruises for Environmental Characterization in the Santos Basin – Methods and Sampling Design
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Moreira, Daniel L.

; Dalto, Adriana G.

; Figueiredo JR, Alberto G.

; Valerio, Aline M.

; Detoni, Amalia M. S.

; Bonecker, Ana C. T.

; Signori, Camila N.

; Namiki, Cláudia

; Sasaki, Dalton K.

; Pupo, Daniel V.

; Silva, Danilo A.

; Kutner, Deborah S.

; Duque-Castaño, Diana C.

; Marcon, Eduardo H.

; Gallotta, Fabiana D. C.

; Paula, Fabiana S.

; Gallucci, Fabiane

; Roque, Gabriela C. F.

; Campos, Giulia S.

; Fonseca, Gustavo

; Mattos, Gustavo

; Lavrado, Helena P.

; Silveira, Ilson C. A. da

; Costa, Jessica O.

; Santos Filho, João R. dos

; Carneiro, Juliane C.

; Moreira, Julio C.F.

; Rozo, Laura

; Araujo, Leandro F.M.

; Lazzari, Letícia

; Silva, Letícia O. da

; Michelazzo, Luan S.

; Fernandes, Luciano F.

; Dottori, Marcelo

; Araújo Jr., Marcus A. G. de

; Chuqui, Mateus G.

; Ceccopieri, Milena

; Borges-Silva, Milton

; Kampel, Milton

; Bergo, Natascha M.

; Silva, Paulo V. M.

; Tura, Pedro M.

; Moura, Rafael B. de

; Romano, Renato G.

; Martins, Renato P.

; Carreira, Renato S.

; Toledo, Rodrigo G.A.

; Bonecker, Sérgio L.C.

; Disaró, Sibelle T.

; Rodrigues, Silvana V.

; Corbisier, Thais N.

; Vicente, Thaisa M.

; Paiva, Vitor G. de

; Pellizari, Vivian H.

; Belo, Wellington C.

; Brandini, Frederico P.

; Sousa, Silvia H.M

Ocean and Coastal Research

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

2023, Volumen 71 Supl. 3 elocation e23022

Resumen: En | Texto: En | PDF: En

Abstract The Santos Basin (SB) is the main petroliferous basin in the Brazilian continental margin and one of the most studied marine areas in Brazil. However, historical data suggest that new efforts should be carried out to acquire quantitative biological data, especially in the deep sea, to establish the baseline of essential ocean variables in different ecosystems for future monitoring programs. The Brazilian energy company Petrobras planned and executed 24 oceanographic cruises over a period of 2 years to assess the benthic (SANSED cruise) and pelagic (SANAGU cruise) systems of the SB (356 days at sea in 2019 and 2021/2022). These efforts were part of the Santos Project, which comprised a comprehensive environmental study aimed at investigating benthic and pelagic variables to characterize ecology, biogeochemistry, thermohaline properties of water masses, and ocean circulation patterns, geomorphology, and sedimentology, as well as organic and inorganic chemistry. Here we present the detailed sampling designs and the field methods employed on board, during the SB scientific cruises. All sampling protocols were based on standardized approaches. For the benthos analyses, triplicate sediment samples were performed using a GOMEX-type box corer (0.25 m²) or a large modified Van Veen grab (0.75 m²) at 100 stations ranging from 25 to 2400 m depth. At each station, 25 geochemical and physico-chemical parameters were analyzed in addition to micro-, meio-, and macrofauna and living foraminifera samples. For the pelagic system, 60 stations were selected to investigate the plankton community, ranging in size from pico- to macroplankton, through vertical, horizontal, and oblique net hauls (20, 200, and 500 μm mesh size), as well as 25 biogeochemical parameters collected with an aid of a CTD-rosette sampler. Part of this scientific information also serves the Regional Environmental Characterization Project (PCR-BS) in support of Petrobras’ Santos Basin drilling licensing process led by the Brazilian Environmental Agency – IBAMA. This project contributes to the sustainable development of the SB, in line with the guidelines of the United Nations Decade of Ocean Science for Sustainable Development.

https://doi.org/10.1590/2675-2824071.22072dlm

[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Marin-Neto, José Antonio Rassi Jr., Anis Moraes Oliveira, Gláucia M. Lemos Correia, Luís Claudio Novaes Ramos Jr., Alberto Hasslocher-Moreno, Alejandro Marcel Luquetti Ostermayer, Alejandro Sousa, Andréa Silvestre de Amato Vincenzo de Paola, Angelo Sobral de Sousa, Antonio Carlos Pinho Ribeiro, Antonio Luiz Correia Filho, Dalmo Moraes de Souza, Dilma do Socorro Cunha-Neto, Edecio J. A. Ramires, Felix Bacal, Fernando Pereira Nunes, Maria do Carmo Martinelli Filho, Martino Ibrahim Scanavacca, Maurício Magalhães Saraiva, Roberto Alves de Oliveira Júnior, Wilson M. Lorga-Filho, Adalberto de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado Braga, Adriana Sarmento de Oliveira, Adriana V. L. Sarabanda, Alvaro Yecê das Neves Pinto, Ana Assis Lopes do Carmo, André Schmidt, André Costa, Andréa Rodrigues da Ianni, Barbara Maria Markman Filho, Brivaldo Eduardo Rochitte, Carlos Thé Macedo, Carolina Mady, Charles Chevillard, Christophe Bittencourt das Virgens, Cláudio Marcelo Nery de Castro, Cleudson De Paoli de Carvalho Britto, Constança Felícia Pisani, Cristiano do Carmo Rassi, Daniela C. Sobral Filho, Dario Rodrigues Almeida, Dirceu A. Bocchi, Edimar T. Mesquita, Evandro de Souza Nogueira Sardinha Mendes, Fernanda Pereira, Francisca Tatiana Sperandio da Silva, Gilberto Marcelo de Lima Peixoto, Giselle Glotz de Lima, Gustavo H. Veloso, Henrique Turin Moreira, Henrique Bellotti Lopes, Hugo Masciarelli Francisco Pinto, Ibraim Pinto Dias, João Carlos Bemfica, João Marcos Silva-Nunes, João Paulo Soares Barreto-Filho, José Augusto Kerr Saraiva, José Francisco Lannes-Vieira, Joseli Menezes Oliveira, Joselina Luzia V. Armaganijan, Luciana Martins, Luiz Cláudio C. Sangenis, Luiz Henrique Barbosa, Marco Paulo Almeida-Santos, Marcos Antônio Simões, Marcos Vinicius Shikanai-Yasuda, Maria Aparecida Vieira Moreira, Maria da Consolação Higuchi, Maria de Lourdes Costa Monteiro, Maria Rita de Cássia Felix Mediano, Mauro Felippe Maia Lima, Mayara T. Oliveira, Maykon Moreira Dias Romano , Minna Nitz, Nadjar de Tarso Jorge Medeiros, Paulo Vieira Alves, Renato Alkmim Teixeira, Ricardo Coury Pedrosa, Roberto Aras, Roque Morais Torres, Rosália dos Santos Povoa, Rui Manoel Rassi, Sérgio Gabriel Salles Xavier, Sérgio Marinho Martins Alves , Silvia B. N. Tavares, Suelene Lima Palmeira, Swamy da Silva Junior, Telêmaco Luiz da Rocha Rodrigues, Thiago Madrini Junior, Vagner Maia da Costa , Veruska Dutra, Walderez

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

Fecha de publicación: 2022-10-11

Resumen: En Pt

This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp; Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities. nbsp; Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp; The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp; The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp; Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.

Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou. A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica. Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas. A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica. A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp; Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;

https://doi.org/10.1590/SciELOPreprints.4820

ESTUDO DO PERFIL QUÍMICO DE CERVEJAS BRASILEIRAS: UMA AVALIAÇÃO ENTRE AS BEBIDAS ARTESANAIS E INDUSTRIAIS
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Coelho Neto, Dorval M.

; Moreira, Laysa L. P. F.

; Castro, Eustáquio V. R. de

; Souza, Warley B.

; Filgueiras, Paulo R.

; Romão, Wanderson

; Folli, Gabriely S.

; Lacerda Jr., Valdemar

Química Nova

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

May 2022, Volumen 45 Nº 5 Paginas 518 - 530

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Beer is commonly produced with four inputs: water, malt, hops, yeast and, in some cases, brewing adjuncts. Industrial and artisanal processes essentially follow the same steps and may undergo minor changes due to the style of beer. Despite this, many consumers attribute higher quality to craft beer compared to industrial ones. In this study, we applied the analytical techniques of infrared (IR), hydrogen nuclear magnetic resonance (1H NMR) and mass spectrometry (ESI(±)FT-ICR MS) to discriminate craft beers from industrial ones (brands common to the Brazilian market). In addition, Partial Least Squares (PLS) and Support Vector Machine (SVR) regression were used to estimate some beer properties (pH, total acidity (meq·L-1, color (EBC), bitterness (IBU), alcohol content (%v/v) and density (g·mL-1)). The use of the IR allowed the identification of vibrations attributed to chemical compounds common to beverages, such as water (3320 and 1640 cm-1), carbohydrates (1500 cm-1) and ethanol (1050-1040 and 875-865 cm-1). 1H NMR showed good applicability in identifying classes of organic compounds in the beverage, where signs attributed to alcohols, organic acids, carbohydrates and amino acids were observed. The ESI(+)FT-ICR MS allowed the identification of chemical compounds present in beverages, allowing the construction of a fingerprint of the beers. In addition, the application of chemometric tools enabled the prediction of physicochemical properties, presenting promising results in the prediction of alcohol content (RMSEC 0.2430 and RMSEP 0.3929) and bitterness (RMSEC 1.3022 and RMSEP 1.6008), and also in the classification regarding the manufacturing process (craft and industrial beer).

https://doi.org/10.21577/0100-4042.20170857

Benzophenone Derivatives Showed Dual Anti-Inflammatory and Antiproliferative Activities by Inhibiting COX Enzymes and Promote Cyclin E Downregulation
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Folquitto, Laís R. S.

; Souza, Thiago B. de

; Januario, Jaqueline P.

; Nascimento, Isadora M.

; Brandão, Brenda T. V.

; Moreira, Maria E. C.

; Horvath, Renato O.

; Santos, Marcelo H.

; Coelho, Luiz F. L.

; Veloso, Marcia P.

; Soares, Marisi G.

; Carvalho, Diogo T.

; Ionta, Marisa

; Chagas-Paula, Daniela A.

; Dias, Danielle F.

Journal of the Brazilian Chemical Society

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

Abr 2022, Volumen 33 Nº 4 Paginas 348 - 360

Resumen: En | Texto: En | PDF: En

Considering the promising antitumor effects of compounds with dual anti-inflammatory and antiproliferative activities, thus benzophenones analogs (2-7) were evaluated on in vivo anti-inflammatory assay and molecular docking analysis. Those with the best molecular docking results were in vitro evaluated on cyclooxygenase (COX) enzymes and tested regarding antiproliferative activity. All derivatives displayed in vivo anti-inflammatory activity. Among them, the substances 2’-hydroxy-4’-benzoylphenyl-β-D-glucopyranoside (4), 4-hydroxy-4’-methoxybenzophenone (5) and 4’-(4’’-methoxybenzoyl)phenyl-β-D-glucopyranoside (7) showed the best values of Glide Score in COX-2 docking evaluation and 4 and 5 selectively inhibited COX-2 and COX-1 in vitro enzymatic assay, respectively. Thus, 4 and 5 were tested against breast cancer (MCF-7, MDA MB-231, Hs578T) and non-small-cell-lung cancer (A549) cell lines. The estrogen-positive MCF-7 cell line was more responsive compared to other tested cell lines. They induced cell cycle arrest at G1/S transition in MCF-7 cell line once there was an increase in G0/G1 population with concomitant reduction of S population. The antiproliferative activity of these substances on MCF-7 was associated with their ability to inhibit cyclin E expression, a critical regulator of G1/S transition. Taken together, the data indicate that 4 and 5 have dual anti-inflammatory and antiproliferative activities and support further studies to evaluate their antitumor potential.

https://doi.org/10.21577/0103-5053.20210154

Iron Recovery from Iron Ore Tailings by Direct Hydrogen Reduction at Low Temperature and Magnetic Separation
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Pinto, Paula S.

; Milagre, Luisa E.

; Moreira, Larissa C. M.

; Rocha Junior, Hamilton P.

; Salviano, Adriana B.

; Ardisson, José D.

; Parreira, Fabrício V.

; Teixeira, Ana Paula C.

; Lago, Rochel M.

Journal of the Brazilian Chemical Society

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

2022, Volumen 33 Nº 8 Paginas 969 - 977

Resumen: En | Texto: En | PDF: En

In this work, we describe a sustainable alternative to recover iron from two iron ore tailings (IOT) using hydrogen reduction at relatively low temperatures followed by magnetic separation. X-ray powder diffraction (XRD), inductively coupled plasma (ICP), atomic absorption (AA), Mössbauer, scanning electron microscopy (SEM/EDS), Raman and thermogravimetry (TG) analyses indicated that the Fe oxide present in the IOTs (sandy tailing (ST) and mud tailings (MT)), can be reduced with H2 at 500 ºC to produce α-Fe. Upon magnetic separation the mud tailing produced a 77 wt.% magnetic fraction increasing the Fe content from 19.2 to ca. 56 wt.% of Fe. On the other hand, the sandy tailing resulted in a 15 wt.% magnetic fraction increasing the Fe content from 19.2 to 70 wt.%. These results indicate that up to 86% of iron can be recovered from the IOT wastes already in the metallic form which can be very interesting for the steel industry.

https://doi.org/10.21577/0103-5053.20220053

CLASSIFICATION OF BANANA RIPENING STAGES BY ARTIFICIAL NEURAL NETWORKS AS A FUNCTION OF PLANT PHYSICAL, PHYSICOCHEMICAL, AND BIOCHEMICAL PARAMETERS
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Bonini Neto, Alfredo

; Souza, Angela V. de

; Bonini, Carolina dos S. B.

; Mello, Jéssica M. de

; Moreira, Adonis

Engenharia Agrícola

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

2022, Volumen 42 Nº 3 elocation e20210197

Resumen: En | Texto: En | PDF: En

ABSTRACT Brazil is currently the 4th world’s largest banana producer, producing around 7 million tons. In this scenario, several studies have been developed with a large amount of data, such as climatic, morphological, and nutritional data, in an attempt to improve these numbers even further. This study aims to classify banana ripening stages by artificial neural networks (ANN) as a function of plant physical, physicochemical, and biochemical parameters. The used ANN consisted of a three-layer feedforward backpropagation network, with eight neurons in the input layer (physical, physicochemical, and biochemical parameters), ten neurons in the intermediate layer, and two neurons in the output layer (classification of banana ripening stages). The results showed three configurations. ANN presented an excellent result for the training phase, with 100% accuracy in the sample classification for the three configurations. The validation and testing phases, that is, the classification of samples that were not part of the training, showed 91.6% and 94.4% accuracy in the first and second configurations, respectively, and 89.5% accuracy in the third configuration.

https://doi.org/10.1590/1809-4430-eng.agric.v42n3e20210197/2022

Solução Intervalar para Ajuste de Curvas Usando o Módulo Python-XSC
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

MARCONE, M. H. F.

; SANTANA, F. T.

; PEREIRA, C. V. M.

; MOREIRA, A. B.

Trends in Computational and Applied Mathematics

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

Sep 2021, Volumen 22 Nº 3 Paginas 359 - 368

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Este trabalho propõem o uso da Matemática Intervalar em conjunto com o Método dos Mínimos Quadrados e a linguagem Python para obter a melhor solução aproximada para sistemas intervalares obtidos de experimentos físicos. Este método de resolução será aplicado para obter a melhor função aproximada que ajusta um conjunto de dados oriundos de um experimento físico, no qual um carro se desloca com aceleração constante sob um trilho de ar inclinado. Ao fazer esse tipo de abordagem usando a Matemática Intervalar, busca-se inferir como as incertezas provenientes do experimento, assim como os erros gerados pelas representações e operações numéricas em computadores, interferem no resultado obtido. Para isso, se fez necessário a utilização da biblioteca Python for Extended Scientific Computing (Python- XSC), a qual é baseada na estrutura da aritmética intervalar e fornece funções para a resolução de sistemas lineares intervalares. A aplicação do estudo feito se mostrou bastante eficiente e de fácil utilização, o que motiva sua utilização.

ABSTRACT In this work, we used the Interval Mathematics, Method of Least Squares and Python language to obtain the best approximate solution for interval systems obtained from physical experiments. This resolution method will be applied to obtain the best approximate function that fits a data set from a physical experiment, in which a car was travels with constant acceleration under an inclined air trail. When doing this type of approach using Interval Mathematics, we seek to infer how the uncertainties arising from the experiment, as well as the errors generated by the representations and operations on computer, interfere with the obtained result. For this, it was necessary to use the Python for Extended Scientific Computing (Python-XSC) library, which is based on the interval arithmetic structure and provides functions for the solving of interval linear systems. The application of the study was very efficient and easy to use, which motivates its use.

https://doi.org/10.5540/tcam.2021.022.03.00359 778 descargas

Automated Framework for Developing Predictive Machine Learning Models for Data-Driven Drug Discovery
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Neves, Bruno J.

; Moreira-Filho, José T.

; Silva, Arthur C.

; Borba, Joyce V. V. B.

; Mottin, Melina

; Alves, Vinicius M.

; Braga, Rodolpho C.

; Muratov, Eugene N.

; Andrade, Carolina H.

Journal of the Brazilian Chemical Society

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

Ene 2021, Volumen 32 Nº 1 Paginas 110 - 122

Resumen: En | Texto: En | PDF: En

The increasing availability of extensive collections of chemical compounds associated with experimental data provides an opportunity to build predictive quantitative structure-activity relationship (QSAR) models using machine learning (ML) algorithms. These models can promote data-driven decisions and have the potential to speed up the drug discovery process and reduce their failure rates. However, many essential aspects of data preparation and modeling are not available in any standalone program. Here, we developed an automated framework for the curation of chemogenomics data and to develop QSAR models for virtual screening using the open-source KoNstanz Information MinEr (KNIME) program. The workflow includes four modules: (i) dataset preparation and curation; (ii) chemical space analysis and structure-activity relationships (SAR) rules; (iii) modeling; and (iv) virtual screening (VS). As case studies, we applied these workflows to four datasets associated with different endpoints. The implemented protocol can efficiently curate chemical and biological data in public databases and generates robust QSAR models. We provide scientists a simple and guided cheminformatics workbench following the best practices widely accepted by the community, in which scientists can adapt to solve their research problems. The workflows are freely available for download at GitHub and LabMol web portals.

https://doi.org/10.21577/0103-5053.20200160 499 descargas

10.

Estudo Comparativo da Doença Coronariana Microvascular Causada por Doença de Chagas e por Outras Etiologias
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Campos, Felipe Araujo

; Magalhães, Mariana L.

; Moreira, Henrique Turin

; Pavão, Rafael B.

; Lima Filho, Moyses O.

; Lago, Igor M.

; Badran, André V.

; Chierice, João R. A.

; Schmidt, André

; Marin Neto, José Antonio

Arquivos Brasileiros de Cardiologia

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

Dic 2020, Volumen 115 Nº 6 Paginas 1094 - 1101

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A doença de Chagas (DC) constitui uma causa potencial negligenciada de doença microvascular coronariana (DMC). Objetivos Comparar pacientes com DMC relacionada à DC (DMC-DC) com pacientes com DMC ligada a outras etiologias (DMC-OE). Métodos De 1292 pacientes estáveis, encaminhados para angiografia coronária invasiva para elucidar o padrão hemodinâmico e a causa de angina, 247 apresentaram coronárias subepicárdicas normais, e 101 foram incluídos após aplicação dos critérios de exclusão. Desses, 15 compuseram o grupo de DMC-DC e suas características clínicas, hemodinâmicas, angiográficas, e cintilográficas foram comparadas às do grupo de 86 pacientes com DMC-OE. O nível de significância estatística para todas as comparações adotado foi de 0,05. Resultados Pacientes com suspeita de DMC-DC apresentaram características antropométricas, clínicas e angiográficas, além de alterações hemodinâmicas e de perfusão miocárdica estatisticamente comparáveis às detectadas nos 86 pacientes com DMC-OE. Disfunção ventricular diastólica, expressa por elevada pressão telediastólica do ventrículo esquerdo, foi igualmente encontrada nos dois grupos. Entretanto, em comparação a esse grupo com DMC-OE, o grupo com DMC-DC exibiu fração de ejeção ventricular esquerda mais baixa (61,1 ± 11,9 vs 54,8 ± 15,9; p= 0,049) e mais elevado escore de mobilidade da parede ventricular (1,77 ± 0,35 vs 1,18 ± 0,26; p= 0,02). Conclusão A cardiomiopatia crônica da doença de Chagas esteve associada à etiologia de possível doença microvascular coronariana em 15% de amostra de 101 pacientes estáveis, cujo sintoma principal era angina requerendo elucidação por angiografia invasiva. Embora os grupos DMC-DC e DMC-OE apresentassem características clínicas, hemodinâmicas, e de perfusão miocárdica em comum, a disfunção global e segmentar do ventrículo esquerdo foi mais grave nos pacientes com DMC associada à DC em comparação à DMC por outras etiologias. (Arq Bras Cardiol. 2020; 115(6):1094-1101)

Abstract Background Chagas disease (CD) as neglected secondary form of suspected coronary microvascular dysfunction (CMD). Objectives Comparison of patients with CMD related to CD (CMD-CE) versus patients with CMD caused by other etiologies (CMD-OE). Methods Of 1292 stable patients referred for invasive coronary angiography to elucidate the hemodynamic pattern and the cause of angina as a cardinal symptom in their medical history, 247 presented normal epicardial coronary arteries and 101 were included after strict exclusion criteria. Of those, 15 had suspected CMD-CE, and their clinical, hemodynamic, angiographic and scintigraphic characteristics were compared to those of the other 86 patients with suspected CDM-OE. Level of significance for all comparisons was p < 0.05. Results Patients with suspected CMD-CE showed most anthropometric, clinical, angiographic hemodynamic and myocardial perfusion abnormalities that were statistically similar to those detected in the remaining 86 patients with suspected CMD-OE. LV diastolic dysfunction, expressed by elevated LV end-diastolic pressure was equally found in both groups. However, as compared to the group of CMD-OE the group with CMD-CE exhibited lower left ventricular ejection fraction (54.8 ± 15.9 vs 61.1 ± 11.9, p= 0.049) and a more severely impaired index of regional wall motion abnormalities (1.77 ± 0.35 vs 1.18 ± 0.26, p= 0.02) respectively for the CMD-OE and CMD-CE groups. Conclusion Chronic Chagas cardiomyopathy was a secondary cause of suspected coronary microvascular disease in 15% of 101 stable patients whose cardinal symptom was anginal pain warranting coronary angiography. Although sharing several clinical, hemodynamic, and myocardial perfusion characteristics with patients whose suspected CMD was due to other etiologies, impairment of LV segmental and global systolic function was significantly more severe in the patients with suspected CMD related to Chagas cardiomyopathy. (Arq Bras Cardiol. 2020; 115(6):1094-1101)

https://doi.org/10.36660/abc.20200381 562 descargas

11.

Synthesis of Glycerol-Derived 4-Alkyl-Substituted 1,2,3-Triazoles and Evaluation of Their Fungicidal, Phytotoxic, and Antiproliferative Activities
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Costa, Adilson V.

; Moreira, Luiza C.

; Pinto, Roberta T.

; Alves, Thammyres A.

; Schwan, Vitor V.

; Queiroz, Vagner T. de

; Praça-Fontes, Milene M.

; Teixeira, Róbson Ricardo

; Morais, Pedro A. B.

; Jesus Júnior, Waldir C. de

Journal of the Brazilian Chemical Society

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

Abr 2020, Volumen 31 Nº 4 Paginas 821 - 832

Resumen: En | Texto: En | PDF: En

Herein, the synthesis of nine novel glycerol-derived 4-alkyl-substituted 1,2,3-triazoles, using the CuI-catalyzed alkyne-azide cycloaddition reaction as the key step, is reported. The triazoles were characterized by infrared and nuclear magnetic resonance (NMR 1H and 13C) spectroscopy and mass spectrometry. The nine prepared compounds were evaluated with regard to their phytotoxic, antiproliferative, and fungicidal activities. The fungicidal activity was assessed on Colletotrichum gloeosporioides, the causative agent of papaya anthracnose. All compounds presented high efficiency (comparable to the commercial fungicide tebuconazole) in inhibiting C. gloeosporioides sporulation. The phytotoxicity of the triazoles was assessed against Lactuca sativa. Germination was the less-affected parameter, whereas the most pronounced effects of the triazoles were on the germination speed index and root growth of the L. sativa seedlings. As indicators of antiproliferative activity, the mitotic index was evaluated along with chromosomal and nuclear alterations, all of which were influenced to different degrees by the triazoles. In addition, all derivatives demonstrated aneugenic and clastogenic actions in meristematic cells of L. sativa roots. Therefore, these 4-alkyl-substituted triazoles may represent a scaffold to be explored for the development of new fungicidal agents.

https://doi.org/10.21577/0103-5053.20190246 372 descargas

12.

REVISITING THE NUCLEOPHILICITY CONCEPT IN A COMPREHENSIVE BIOMASS VALORIZATION EXPERIMENT: FROM PAPAYA SEEDS TO THIOUREA MOTIFS
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Santos, Raquel V. dos

; Viana, Gil M.

; Moreira, Anderson Felipe S.

; Nóbrega, Vitor S.

; Silva, Vitor A. S. da

; Malta, Luiz Fernando B.

; Aguiar, Lucia C. S.

; Senra, Jaqueline D.

Química Nova

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

Ago 2019, Volumen 42 Nº 8 Paginas 940 - 946

Resumen: En | Texto: En | PDF: En

The recovery of waste materials with potential for synthetic transformations is a major field in science. However, just few experiments have been devoted to undergraduate students by exploring some consistent subjects in light of simple, natural resources. Nucleophilicity is a central subject in chemistry and there are significant synthetic models to exploit it in contrast to basicity. Here we present a laboratory experiment that utilizes hands-on research to be implemented in an organic chemistry lab by using benzyl isothiocyanate (BITC) from papaya seeds as raw material for the preparation of thioureas in a fast and visually indicative experiment. Subjects such as green chemistry, extraction methods, nucleophilicity, chromatography and NMR spectroscopy can be emphasized in order to implement a project-based approach. This experiment shows flexibility concerning the procedures and the use of biomass raw materials towards the reinforcement of a research-like experience and critical-thinking skills.

https://doi.org/10.21577/0100-4042.20170395 679 descargas

13.

3ª Diretriz Brasileira de Transplante Cardíaco
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Bacal, Fernando

; Marcondes-Braga, Fabiana G.

; Rohde, Luis Eduardo Paim

; Xavier Júnior, José Leudo

; Brito, Flávio de Souza

; Moura, Lídia Ana Zytynski

; Colafranceschi, Alexandre Siciliano

; Lavagnoli, Carlos Fernando Ramos

; Gelape, Cláudio Leo

; Almeida, Dirceu Rodrigues

; Gaiotto, Fábio Antônio

; Atik, Fernando Antibas

; Figueira, Fernando Augusto M. S.

; Souza, Germano Emílio Conceição

; Rodrigues, Hélcio

; Campos, Iáscara Wozniak

; Souza Neto, João David de

; Rossi Neto, João Manoel

; Gasparetto, Juliano

; Goldraich, Lívia Adams

; Benvenuti, Luiz Alberto

; Seguro, Luis Fernando B. C.

; Ulhôa Júnior, Marcelo Botelho

; Moreira, Maria da Consolação V.

; Ávila, Mônica Samuel

; Carneiro, Rodrigo

; Mangini, Sandrigo

; Ferreira, Sílvia Moreira Ayub

; Strabelli, Tânia Mara

Arquivos Brasileiros de Cardiologia

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

Ago 2018, Volumen 111 Nº 2 Paginas 230 - 289

Resumen: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.5935/abc.20180153 28659 descargas

14.

High species richness of native pollinators in Brazilian tomato crops
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Silva-Neto, C. M.

; Bergamini, L. L.

; Elias, M. A. S.

; Moreira, G. L.

; Morais, J. M.

; Bergamini, B. A. R.

; Franceschinelli, E. V.

Brazilian Journal of Biology

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

Jul 2017, Volumen 77 Nº 3 Paginas 506 - 513

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Polinizadores fornecer um serviço essencial para os ecossistemas naturais e para agricultura. Em tomateiros, as anteras são poricidas e o pólen pode sair a partir dos poros quando as flores são agitadas pelo vento. No entanto, as abelhas que vibram as anteras aumentam a carga de pólen no estigma e na produção de frutos. O presente estudo teve como objetivo identificar a riqueza dos polinizadores das flores de tomate e investigar suas características morfológicas e funcionais relacionadas com a interação planta-polinizador em plantações do Brasil central. Foram registrados o tempo de antese, duração flor, bem como o número e viabilidade de grãos de pólen e óvulos. Os visitantes florais foram observados e coletados. Os botões florais abriram-se em torno 06h30 e fechou em torno de 18h00. As flores reabrem no dia seguinte ao mesmo tempo na parte da manhã, com longevidade média de 48 horas. A maior disponibilidade de pólen ocorreu durante as primeiras horas da antese. Depois disso, o número de grãos de pólen diminuiu, especialmente entre as 10h00 às 12h00, o que é consistente com os padrões de visitação de polinizadores. Quarenta espécies de abelhas foram encontradas nos campos de tomate, 30 das quais foram consideradas polinizadores. Durante o período de floração, as plantas oferecem enorme quantidade de pólen para os seus visitantes. Isto pode explicar a alta riqueza e quantidade de abelhas que visitam as flores de tomate nas áreas de estudo. O período de disponibilidade e redução de pólen durante todo o período do dia é sobreposto com o período de alimentação das abelhas, o que sugere que elas são altamente eficazes na remoção de grãos de pólen das anteras. Muitos desses grãos provavelmente são depositados no estigma da mesma flor, levando à auto-polinização e o desenvolvimento de frutos. Abelhas nativas (Exomalopsis spp.) são polinizadores efetivos de flores de tomate, podendo contribuir para o aumento da produtividade das culturas. Por outro lado, as flores de tomate oferecem grandes quantidades de pólen de recursos para uma alta riqueza e quantidade de abelhas, que mostram um estudo forte interação planta-polinizador nos agroecossistemas.

Abstract Pollinators provide an essential service to natural ecosystems and agriculture. In tomatoes flowers, anthers are poricidal, pollen may drop from their pore when flowers are shaken by the wind. However, bees that vibrate these anthers increase pollen load on the stigma and in fruit production. The present study aimed to identify the pollinator richness of tomato flowers and investigate their morphological and functional traits related to the plant-pollinator interaction in plantations of Central Brazil. The time of anthesis, flower duration, and the number and viability of pollen grains and ovules were recorded. Floral visitors were observed and collected. Flower buds opened around 6h30 and closed around 18h00. They reopened on the following day at the same time in the morning, lasting on average 48 hours. The highest pollen availability occurred during the first hours of anthesis. Afterwards, the number of pollen grains declined, especially between 10h00 to 12h00, which is consistent with the pollinator visitation pattern. Forty bee species were found in the tomato fields, 30 of which were considered pollinators. We found that during the flowering period, plants offered an enormous amount of pollen to their visitors. These may explain the high richness and amount of bees that visit the tomato flowers in the study areas. The period of pollen availability and depletion throughout the day overlapped with the bees foraging period, suggesting that bees are highly effective in removing pollen grains from anthers. Many of these grains probably land on the stigma of the same flower, leading to self-pollination and subsequent fruit development. Native bees (Exomalopsis spp.) are effective pollinators of tomato flowers and are likely to contribute to increasing crop productivity. On the other hand, here tomato flowers offer large amounts of pollen resource to a high richness and amount of bees, showing a strong plant-pollinator interaction in the study agroecosystem.

https://doi.org/10.1590/1519-6984.17515 1825 descargas

15.

UTILIZATION OF CO2 IN SEMI-CONTINUOUS CULTIVATION OF Spirulina sp. AND Chlorella fusca AND EVALUATION OF BIOMASS COMPOSITION
Facebook Twitter

Otras redes sociales
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Otras redes

Métrica
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Moreira, J. B.

; Terra, A. L. M.

; Costa, J. A. V.

; Morais, M. G.

Brazilian Journal of Chemical Engineering

Métricas del periódico
- Sobre o periódico
- SciELO Analytics

Sep 2016, Volumen 33 Nº 3 Paginas 691 - 698

Resumen: En | Texto: En | PDF: En

Abstract Cultivation conditions and the process considerably influence the composition of microalgae. The objective of this study was to use CO2 as a carbon source in semi-continuous cultivation of Spirulina sp. LEB 18 and Chlorella fusca LEB 111 and to evaluate the influence of the renewal rate on the biomass composition and production of these microalgae. Spirulina sp. LEB 18 and Chlorella fusca LEB 111 were cultivated with 10% (v/v) CO2. The blend concentration was 1.6 g L-1, and 20 and 40% (v/v) renewal rates were studied. Spirulina sp. LEB 18 presented the best kinetic results and the maximum biomass concentration and biopolymer yield when grown with CO2 as the carbon source. Under the same conditions (10% (v/v) CO2), the microalgae Spirulina sp. LEB 18 and Chlorella fusca LEB 111 exhibited maximum levels of protein, carbohydrates and lipids.

https://doi.org/10.1590/0104-6632.20160333s20150135 3019 descargas

Mostrar

itens por página

Página de 2 Próxima

Seleccione uno o más resultados

Todos Ordem alfabética

Resultados

Gráfico comparativo Descargar CSV

Visualizar estadísticas de

Enviar resultado

E-mail do(s) destinatário(s)*

Utilize ; (punto y coma) para más de un correo.

Enviar por correo-e

Esta página

Registros seleccionados

Todas las referencias (max. 300)

Su email

Asunto

Comentarios

Formato de exportación:

RIS (para EndNote, ProCite, Reference Manager, RefWorks, Citavi, etc.)

BibTeX

Citación

CSV (para Excel, etc)

Exportar:

Esta página

Itens seleccionados

Todas las referencias (max. 2000)

Sem resultados

No se encontraron documentos para su búsqueda

Glosario y ayuda para la búsqueda

Ud. puede enriquecer su búsqueda de una forma muy sencilla. Use los índices de búsqueda combinados con los conectores (AND u OR) para especificar su busca.

Por ejemplo, si desea buscar artículos acerca de
casos de dengue en el Brasil en 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

A continuación se muestra la lista completa de los índices de búsqueda que se pueden utilizar:

Cód. del Índice	Elemento
ti	título del articulo
au	autor
kw	palabras clave del artículo
subject	asunto (palabras del título, resumen y palabras clave)
ab	resumen
ta	título abreviado de la revista (ej. Cad. Saúde Pública)
journal_title	título completo de la revista (ej. Cadernos de Saúde Pública)
la	código de idioma de publicación (ej. pt - Portugués, es - Español)
type	tipo de documento
pid	identificador de la publicación
publication_year	año de publicación del artículo
sponsor	financiador
aff_country	código del país de la afiliación del autor
aff_institution	institución de filiación del autor
volume	volumen del artículo
issue	número del artículo
elocation	elocation
doi	número DOI
issn	ISSN de la revista
in	código de la colección SciELO (ej. scl - Brasil, col - Colômbia)
use_license	código de licencia de uso del artículo

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
Email: scielo@scielo.org

Todo el contenido de este sitio www.scielo.br, excepto dónde está identificado, está bajo una Licencia de Atribución Creative Commons.
sepa más »