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ABSTRACT Objective: To verify the relationship between the presence of proteinuria as a renal injury marker in elderly without history of systemic arterial hypertension and cardiovascular diseases. A cross-sectional study was developed from January 2014 to December 2019, through kidney disease prevention campaigns promoted by the Federal University of Ceará in the city of Fortaleza. Methods: The sample consisted of 417 elderlies. A questionnaire was used to characterize individuals and assess previous diseases, and urinalysis reagent strips were used to assess proteinuria. Results: Statistically significant differences (p < 0.05) and moderate effect sizes were found for blood pressure levels (CI 0.53-0.93), systolic blood pressure, and diastolic blood pressure (CI 0.21-0.61). Significant differences in capillary glycemia were also found between groups (p = 0.033), but with a low effect size (0.02–0.42). The group with comorbidities was 2.94 times more likely to have proteinuria than those without comorbidities (OR 2.94, CI 1.55-4.01; p < 0.05). In the group without cardiovascular disease/high blood pressure, a statistically significant association was found for previous diabetes and proteinuria (p = 0.037), presenting 2.68 times higher risk of proteinuria in those with diabetes mellitus (OR 2.68, CI 1.05-6.85). Significant association was also found between age groups, with the older group having 2.69 times higher risk of developing proteinuria (75 to 90 compared to 60 to 74 years) (CI 1.01-7.16; p = 0.045). Conclusion: Even without systemic arterial hypertension or cardiovascular disease, diabetes and older age can be considered high risk factors for proteinuria.

Resumo Objetivo: Verificar a relação entre a presença de proteinúria como marcador de lesão renal em idosos sem histórico de hipertensão arterial sistêmica e doenças cardiovasculares. Um estudo transversal foi desenvolvido de Janeiro de 2014 a Dezembro de 2019, por meio de campanhas de prevenção a doenças renais promovidas pela Universidade Federal do Ceará, na cidade de Fortaleza. Métodos: A amostra foi composta por 417 idosos. Um questionário foi usado para caracterizar indivíduos e avaliar doenças prévias, e foram utilizadas tiras reagentes de urinálise para avaliar proteinúria. Resultados: Diferenças estatisticamente significativas (p < 0,05) e tamanhos de efeito moderados foram encontrados para níveis de pressão arterial (IC 0,53-0,93), pressão arterial sistólica e pressão arterial diastólica (IC 0,21-0,61). Também foram encontradas diferenças significativas na glicemia capilar entre grupos (p = 0,033), mas com um tamanho de efeito baixo (0,02–0,42). O grupo com comorbidades apresentou 2,94 vezes mais probabilidade de ter proteinúria do que aqueles sem comorbidades (OR 2,94; IC 1,55-4,01; p < 0,05). No grupo sem doença cardiovascular/hipertensão, foi encontrada uma associação estatisticamente significativa para diabetes anterior e proteinúria (p = 0,037), apresentando risco 2,68 vezes maior de proteinúria naqueles com diabetes mellitus (OR 2,68; IC 1,05-6,85). Também foi encontrada uma associação significativa entre faixas etárias, com o grupo mais velho apresentando risco 2,69 vezes maior de desenvolver proteinúria (75 a 90 em comparação com 60 a 74 anos) (IC 1,01-7,16; p = 0,045). Conclusão: Mesmo sem hipertensão arterial sistêmica ou doença cardiovascular, o diabetes e a idade avançada podem ser considerados fatores de alto risco para proteinúria.

https://doi.org/10.1590/2175-8239-jbn-2022-0028en

Litterfall production, decomposition and litter nutrient contents in a mined area revegetated with different forest species
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Valente, Fernanda Daniele de Almeida

; Castro, Marllon Fialho de

; Lustosa Filho, José Ferreira

; Lopes, Aldo Teixeira

; Borges, Silvano Rodrigues

; Gomes, Lucas Carvalho

; Neves, Júlio César Lima

; Silva, Ivo Ribeiro da

; Oliveira, Teogenes Senna de

Revista Brasileira de Ciência do Solo

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2023, Volumen 47 elocation e0220122

Resumen: En | Texto: En | PDF: En

ABSTRACT Afforestation of sites disturbed after bauxite mining is the favorite technique to restore all ecosystem functions. The nature of the tree species used for revegetation of post-mining land can accelerate the recovery of soil organic matter and nutrient cycles. This study aimed to determine the litterfall production, decomposition rate and nutrient content from three types of forest cover ( Eucalyptus , Anadenanthera peregrina , mixed plantation of 16 native species) planted in a bauxite mining area in recovery. Litterfall production was evaluated monthly over 30 months, and the litter mass was assessed twice a year (dry and rainy periods). Total nutrient content was determined from samples grouped by period (dry and rainy). The annual average values for litterfall dry mass and litter mass were higher in Eucalyptus and mixed native. The period (dry or rainy) did not influence litterfall rates in A. peregrina , but Eucalyptus and mixed native presented higher amounts for litterfall during the rainy and dry periods, respectively. Litter accumulation in Eucalyptus was not affected by the season of the year, but mixed native and A. peregrina presented higher litter accumulation in the dry season. Apparent decomposition rates of A. peregrina and mixed native were higher in the rainy season, highlighting the A. peregrina with the highest values compared with the other forest covers. The mixed native presented the highest leaf content of P, K, Ca and Mg in both the litterfall and litter mass, while Eucalyptus had the lowest P, K, Ca, S and N content and the highest C content in the litterfall. Litterfall production is important in degraded areas to ensure the nutrient return to the soil. The data obtained suggest that the cultivation of a mixed of 16 native trees contribute for produce the higher annual litterfall yields, besides produces leaf litterfall of better nutritional quality in relation to P, K, Ca, Mg and S. Therefore, mixed of native trees can be a promising option for reactivation of nutrient cycling and organic matter formation in mined area of bauxite in the Brazilian Atlantic Forest.

https://doi.org/10.36783/18069657rbcs20220122

Diretriz Brasileira de Dispositivos Cardíacos Eletrônicos Implantáveis – 2023
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Teixeira, Ricardo Alkmim

; Fagundes, Alexsandro Alves

; Baggio Junior, José Mário

; Oliveira, Júlio César de

; Medeiros, Paulo de Tarso Jorge

; Valdigem, Bruno Pereira

; Teno, Luiz Antônio Castilho

; Silva, Rodrigo Tavares

; Melo, Celso Salgado de

; Elias Neto, Jorge

; Moraes Júnior, Antonio Vitor

; Pedrosa, Anisio Alexandre Andrade

; Porto, Fernando Mello

; Brito Júnior, Hélio Lima de

; Souza, Thiago Gonçalves Schroder e

; Mateos, José Carlos Pachón

; Moraes, Luis Gustavo Belo de

; Forno, Alexander Romeno Janner Dal

; D’Avila, Andre Luiz Buchele

; Cavaco, Diogo Alberto de Magalhães

; Kuniyoshi, Ricardo Ryoshim

; Pimentel, Mauricio

; Camanho, Luiz Eduardo Montenegro

; Saad, Eduardo Benchimol

; Zimerman, Leandro Ioschpe

; Oliveira, Eduardo Bartholomay

; Scanavacca, Mauricio Ibrahim

; Martinelli Filho, Martino

; Lima, Carlos Eduardo Batista de

; Peixoto, Giselle de Lima

; Darrieux, Francisco Carlos da Costa

; Duarte, Jussara de Oliveira Pinheiro

; Galvão Filho, Silas dos Santos

; Costa, Eduardo Rodrigues Bento

; Mateo, Enrique Indalécio Pachón

; Melo, Sissy Lara De

; Rodrigues, Thiago da Rocha

; Rocha, Eduardo Arrais

; Hachul, Denise Tessariol

; Lorga Filho, Adalberto Menezes

; Nishioka, Silvana Angelina D’Orio

; Gadelha, Eduardo Barreto

; Costa, Roberto

; Andrade, Veridiana Silva de

; Torres, Gustavo Gomes

; Oliveira Neto, Nestor Rodrigues de

; Lucchese, Fernando Antonio

; Murad, Henrique

; Wanderley Neto, José

; Brofman, Paulo Roberto Slud

; Almeida, Rui M. S.

; Leal, João Carlos Ferreira

Arquivos Brasileiros de Cardiologia

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2023, Volumen 120 Nº 1 elocation e20220892

Resumen: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20220892

Time of clerkship rotations’ interruption during COVID-19 and differences on Progress Test’s scores
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Hamamoto Filho, Pedro Tadao

; Moriguti, Júlio César

; Ribeiro, Zilda Maria Tosta

; Diehl, Leandro

; Lopes, Ricardo Dantas

; Adler, Ubiratan Cardinalli

; Lima, Alba Regina de Abreu

; Oliveira, Rodrigo Cardoso de

; Andrade, Maria Cristina de

; Bicudo, Angélica Maria

Revista da Associação Médica Brasileira

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Oct 2022, Volumen 68 Nº 10 Paginas 1447 - 1451

Resumen: En | Texto: En | PDF: En

SUMMARY OBJECTIVES: The transition from face-to-face to remote teaching is yet to be fully understood. In clinical training, traditional teaching must prevail because it is essential for the acquisition of skills and professionalism. However, the responses of each school to the pandemic and the decision on when to resume clerkship rotations were mixed. In this study, we aimed to analyze whether the time to resume clerkship rotations was associated with the performance of the students by using a multi-institutional Progress Test. METHODS: This is a cross-sectional study conducted at nine different Brazilian medical schools that administer the same annual Progress Test for all students. We included information from 1,470 clerkship medical students and analyzed the time of clinical training interruption as the independent variable and the student’s scores as the dependent variable. RESULTS: The comparisons of the students’ scores between the schools showed that there are differences; however, they cannot be attributed to the time the clerkship rotations were paused. The correlation between the schools’ average scores and the time to resume clerkship rotations was not significant for the fifth year (r= -0.298, p=0.436) and for the sixth year (r= -0.440, p=0.240). By using a cubic regression model, the time to resume clerkship rotations could explain 3.4% of the 5-year students’ scores (p<0.001) and 0.9% of the 6–year students, without statistical difference (p=0.085). CONCLUSIONS: The differences between the students’ scores cannot be attributed to the time when the schools paused the clerkship rotations.

https://doi.org/10.1590/1806-9282.20220657

Perioperative management in gynecological surgery based on the ERAS program
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Santiago, Aline Evangelista

; Silva Filho, Agnaldo Lopes da

; Cândido, Eduardo Batista

; Ribeiro, Paulo Ayrosa

; Silva, Julio César Rosa e

; Primo, Walquíria Quida Salles Pereira

; Carvalho, Jesus Paula

; Podgaec, Sérgio

; Lino, Carlos Augusto Pires Costa

; Quintáiros, Ricardo de Almeida

; Brito, Luiz Gustavo Oliveira

Revista Brasileira de Ginecologia e Obstetrícia

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Feb 2022, Volumen 44 Nº 2 Paginas 202 - 209

Resumen: En | Texto: En | PDF: En

https://doi.org/10.1055/s-0042-1743401

Chronic kidney disease prevention campaign: relationship between proteinuria and elderly people
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Nunes Filho, Júlio César Chaves

; Camurça, David Silva

; Rocha, Gabriel Alves

; Oliveira, Ana Beatriz Timbó de

; Marinho, Gabriela Correia Pequeno

; Santos, Sérgio Gabriel Monteiro

; Pereira, Dyego Castelo Branco Holanda Gadelha

; Meneses, Gdayllon Cavalcante

; Daher, Elizabeth De Francesco

Brazilian Journal of Nephrology

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2022, Nº ahead

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/2175-8239-jbn-2022-0028en

Fertility preservation in women with endometriosis Number 10 - October 2021
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Carneiro, Márcia Mendonça

; Cunha Filho, João Sabino Lahorgue da

; Petta, Carlos Alberto

; Lino, Carlos Augusto Pires Costa

; Castro, Corival Lisboa Alves de

; Schor, Eduardo

; Nogueira Neto, João

; Oliveira, Marco Aurélio Pinho de

; Tcherniakovsky, Marcos

; Abrão, Maurício Simões

; Poli Neto, Omero Benedicto

; Quintairos, Ricardo de Almeida

; Pearce, Sidney

; Abdalla, Helizabet Salomão

; Silva, Julio Cesar Rosa e

Revista Brasileira de Ginecologia e Obstetrícia

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Oct 2021, Volumen 43 Nº 10 Paginas 796 - 801

Resumen: En | Texto: En | PDF: En

https://doi.org/10.1055/s-0041-1739234

Gynecological Surgery and COVID-19: What is the Impact and How Should I Manage it?
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Rosa-e-Silva, Julio Cesar

; Ribeiro, Paulo Ayroza

; Brito, Luiz Gustavo Oliveira

; Gomes, Mariano Tamura Vieira

; Podgaec, Sergio

; Ribeiro, Helizabet Salomão Abdalla Ayroza

; Lino, Carlos Augusto Pires Costa

; Quintairos, Ricardo

; Primo, Walquiria Quida Salles Pereira

; Silva Filho, Agnaldo Lopes da

Revista Brasileira de Ginecologia e Obstetrícia

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Jul 2020, Volumen 42 Nº 7 Paginas 415 - 419

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Estima-se que cerca de 28 milhões de cirurgias sejam postergadas ou canceladas nomundo em decorrência desta pandemia, causando atraso no diagnóstico e tratamento de mais de 2 milhões de casos oncológicos. No Brasil, tanto a ANS (Agencia Nacional de Saúde) comoa ANVISA (Agencia Nacional de Vigilância Sanitária) orientaram o adiamento das cirurgias eletivas e não essenciais, tendo um impacto considerável no número de procedimentos cirúrgicos comdiminuição de 33,4% neste período no Brasil.No entanto, algumasmulheres necessitam de tratamento para várias doenças ginecológicas, algumas das quais não podem ser adiadas. O objetivo deste artigo é apresentar recomendações sobre o tratamento cirúrgico durante a pandemia de COVID-19.

Abstract It is estimated that around 28 million surgeries will be postponed or canceled worldwide as a result of this pandemic, causing a delay in the diagnosis and treatment of more than 2 million cancer cases. In Brazil, both the National Health Agency (ANS) and National Health Surveillance Agency (ANVISA) advised the postponement of elective and non-essential surgeries, causing a considerable impact on the number of surgical procedures that decreased by 33.4% in this period. However, some women need treatment for various gynecological diseases that cannot be postponed. The purpose of this article is to present recommendations on surgical treatment during the COVID-19 pandemic.

https://doi.org/10.1055/s-0040-1715146 629 descargas

Phytomass input and nutrient cycling under different management systems in dwarf cashew cultivation
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Morais, Gislane Mendes de

; Lustosa Filho, José Ferreira

; Saraiva, João Paulo Bezerra

; Sousa, Helon Hebano de Freitas

; Neves, Júlio César Lima

; Mendonça, Eduardo de Sá

; Oliveira, Teógenes Senna de

Revista Brasileira de Ciência do Solo

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2020, Volumen 44 elocation e0200034

Resumen: En | Texto: En | PDF: En

ABSTRACT Rational management of spontaneous plants is an alternative for increasing productivity in tree crops. This study aimed to evaluate the impact of management systems between rows and under the canopy of early dwarf cashew trees on the soil chemical properties and light-fraction organic matter and cashew root systems; we also evaluated the nutrient inputs from the spontaneous plants phytomass and cashew leaves deposited on an Arenic Kandiustults. The management systems under study were disc harrowing (DH) and mechanical mowing (MM) between rows, both with clearing under the cashew canopy (crowning), and herbicide (HERB) between the rows and under the canopy (without crowning). Soil and plant samples (leaves, stems, and roots) were collected at three points: under the canopy, at the canopy projected limit, and between the rows of cashew plants, all after seven years of conducting the experiment. Soil samples collected at the layers of 0.00-0.05, 0.05-0.10, 0.10-0.20, and 0.20-0.30 m were evaluated for total organic carbon, light-fraction organic matter, and chemical attributes. Dry matter, Na, Ca, Mg, N, P, and K were determined in the spontaneous-plant phytomass from under the canopy, at the canopy projected limit, and between the rows. Results showed that between rows of cashew trees there are higher phytomass input and increases in the light fraction of organic matter, pH and Mg2+ in the soil in the treatment MM. Not removing crop residues or spontaneous plants by crowning promoted accumulation of organic material and higher contents of nutrients under the canopy. The management of spontaneous plants and also soil surface under the canopy of the cashew plants had a great influence on productivity. The crowning, used in MM and DH, led to lower productivity, 1,171.87 and 594.97 kg ha-1, respectively, when compared with the absence of crowning (HERB), which resulted in productivity of 1,363.80 kg ha-1. The practice of crowning is not recommended for soil management systems in dwarf cashew crops.

https://doi.org/10.36783/18069657rbcs20200034 121 descargas

10.

Alprostadil associated with low molecular weight heparin to treat limb ischemia caused by SARS-CoV2
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Manhanelli Filho, Marcos Antonio Bonacorso

; Duarte Júnior, Eliud Garcia

; Mariuba, Jamil Victor de Oliveira

; Linardi, Fábio

; Costa, José Augusto

; Gali, Julio Cesar

; Yoshida, Winston Bonetti

; Gali Filho, Julio Cesar

Jornal Vascular Brasileiro

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2020, Volumen 19 elocation e20200072

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A atual pandemia de coronavírus já gerou danos profundos ao redor do mundo, causando grande quantidade de morbidades e mortes. Uma das manifestações das formas graves da doença é o estado trombofílico, que pode provocar danos em vários sistemas. Este artigo relata o caso de uma paciente do sexo feminino, 60 anos de idade, que foi internada em um serviço hospitalar privado com sintomas gripais inespecíficos leves, mas que progrediu com trombose arterial e isquemia de membros causada pelo SARS-CoV2. Devido à essa evolução, foi optada pela administração concomitante de heparina de baixo peso molecular e Alprostadil, com bom desfecho clínico. Nossa descrição objetiva identificar pontos-chave e sinais clínicos que evidenciem essa janela terapêutica, bem como uma opção de tratamento para as apresentações coagulatórias da COVID-19.

Abstract The current coronavirus pandemic has already taken a great toll globally, causing massive morbidity and mortality. One of its severe forms is a thrombophilic state that can damage several systems. This article reports the case of 60-year-old female patient who presented with mild flu symptoms, which turned out to be a SARS-CoV2 infection, and ended up developing arterial thrombosis with limb ischemia in a private care hospital in Sorocaba, São Paulo, Brazil. Considering this progression, we decided to intervene with low molecular weight heparin and Alprostadil, achieving a good clinical outcome. Our description aims to identify key points and clinical signs that offer evidence of the therapeutic window and a treatment option for coagulatory presentations of COVID-19.

https://doi.org/10.1590/1677-5449.200072 553 descargas

11.

Morphological diversity of springtails (Hexapoda: Collembola) as soil quality bioindicators in land use systems
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Machado, Julia da Silva

; Oliveira Filho, Luís Carlos Iuñes

; Santos, Julio Cesar Pires

; Paulino, Alexandre Tadeu

; Baretta, Dilmar

Biota Neotropica

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2019, Volumen 19 Nº 1 elocation e20180618

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi avaliar a qualidade do solo de florestas nativas, reflorestamento de eucalipto, pastagem, sistemas de integração lavoura-pecuária e plantio direto, correlacionando a diversidade morfológica de colêmbolos com propriedades físicas e químicas do solo. Amostras de colêmbolos foram coletadas de solos do planalto sul do Estado de Santa Catarina no Brasil, durante o inverno e o verão, usando armadilhas de queda, em grade amostral de 3 × 3. A morfotipagem dos colêmbolos consistiu na observação de cinco características e para cada uma foi atribuído um valor parcial do índice eco-morfológico para a obtenção do Índice de Qualidade do Solo modificado. As avaliações foram da abundância e diversidade de morfotipos e de atributos físicos (umidade do solo, densidade do solo, bioporos, microporosidade e macroporosidade) e químicos do solo (pH em água, relação cálcio/magnésio e carbono orgânico total), descrevendo os resultados por análises de variância e multivariada. A abundância e a diversidade de colêmbolos foram influenciadas pelos diferentes sistemas de uso do solo. Maior índice de qualidade do solo foi determinado em floresta nativa seguida de reflorestamento de eucalipto, pastagem, plantio direto e integração lavoura-pecuária, no inverno. Além disso, encontrou-se maior índice de qualidade do solo em floresta nativa seguida de integração lavoura-pecuária, reflorestamento de eucalipto, plantio direto e pastagem, no verão. Portanto, o índice de qualidade do solo pode ser avaliado pelas características morfológicas de colêmbolos em correlação com as propriedades físicas e químicas, como razão cálcio/magnésio, teores de carbono orgânico total, bioporos, macroporosidade, microporosidade, umidade do solo, densidade do solo e pH.

Abstract: The aim of this work was to evaluate the soil quality of native forest, eucalyptus plantations, pasture, integrated crop-livestock, and no-tillage systems, correlating the morphological diversity of springtails with physical and chemical soil properties. Springtail samples were captured from soils of the southern plateau of the State of Santa Catarina in Brazil, during winter and summer, by using Pitfall traps, using a 3 × 3 point grid. The morphotyping of springtails consisted of the observation of five traits and for each one a partial value of the eco-morphological index was assigned to obtain the modified Soil Quality Index. A correlation of the morphotype abundance and diversity with physical (soil moisture, bulk density, biopores, microporosity, and macroporosity) and chemical (pH in water, calcium/magnesium ratio and total organic carbon content) soil properties was studied, describing all results by variance and multivariate analyses. The springtail abundance and diversity were influenced by the different land use systems. Higher soil quality index was determined in native forest followed by eucalyptus plantations, pasture, no-tillage system and integrated crop-livestock, in the winter. Moreover, higher soil quality index was found in native forest followed by integrated crop-livestock, eucalyptus plantations, no-tillage system and pasture, in the summer. Therefore, the quality index of a soil can be evaluated by the springtail morphological traits in correlation with the physical and chemical properties such as calcium/magnesium ratio, total organic carbon contents, biopores, macroporosity, microporosity, soil moisture, bulky density and pH.

https://doi.org/10.1590/1676-0611-bn-2018-0618 2288 descargas

12.

Land use dynamics in the Brazilian Cerrado in the period from 2002 to 2013
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Sano, Edson Eyi

; Rosa, Roberto

; Scaramuzza, Carlos Alberto de Mattos

; Adami, Marcos

; Bolfe, Edson Luis

; Coutinho, Alexandre Camargo

; Esquerdo, Júlio César Dalla Mora

; Maurano, Luís Eduardo Pinheiro

; Narvaes, Igor da Silva

; Oliveira Filho, Francisco José Barbosa de

; Silva, Elaine Barbosa da

; Victoria, Daniel de Castro

; Ferreira, Laerte Guimarães

; Brito, Jorge Luís Silva

; Bayma, Adriana Panhol

; Oliveira, Gustavo Henrique de

; Bayma-Silva, Gustavo

Pesquisa Agropecuária Brasileira

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2019, Volumen 54 elocation e00138

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi analisar a dinâmica de uso das terras na região do Cerrado de 2002 a 2013. Essa análise foi baseada nas interpretações de imagens do satélite Landsat realizadas pelo Projeto de Conservação e Utilização Sustentável da Diversidade Biológica Brasileira (Probio) e pelo projeto TerraClass Cerrado 2013, coordenados pelo Ministério do Meio Ambiente. Em 2002, 38,9% do Cerrado eram cobertos por algum tipo de atividade antrópica. Em 2013, essa percentagem passou para 43,4%. Um dos grandes destaques é o surgimento de uma nova fronteira agrícola na região norte da área de estudo, conhecida como Matopiba.

Abstract: The objective of this work was to analyze land use dynamics in the Brazilian Cerrado region from 2002 to 2013. This analysis was based on the interpretation of Landsat satellite images carried out by the projects Projeto de Conservação e Utilização Sustentável da Diversidade Biológica Brasileira (Probio) and TerraClass Cerrado 2013, both coordinated by Ministério do Meio Ambiente. In 2002, 38.9% of the Cerrado was covered by some type of anthropic activity. In 2013, this percentage increased to 43.4%. One of the main highlights is the emergence of a new agricultural frontier in the northern region of the study area, known as Matopiba.

https://doi.org/10.1590/s1678-3921.pab2019.v54.00138 1955 descargas

13.

Synthesis by Click Reactions and Antiplasmodial Activity of Lupeol 1,2,3-Triazole Derivatives
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Borgati, Tatiane F.

; Pereira, Guilherme R.

; Brandão, Geraldo C.

; Santos, Juliana O.

; Fernandes, Dayane Aparecida M.

; Paula, Renata C. de

; Nascimento, Maria Fernanda A. do

; Soares, Luciana F.

; Lopes, Júlio César D.

; Souza Filho, José D. de

; Oliveira, Alaíde B. de

Journal of the Brazilian Chemical Society

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Oct 2017, Volumen 28 Nº 10 Paginas 1850 - 1856

Resumen: En | Texto: En | PDF: En

Lupeol, a triterpene frequently found in Asteraceae plant species, showed moderate to low activity in different strains of Plasmodium falciparum, the most virulent malaria etiological agents. In this work, lupeol was isolated from Parahancornia fasciculata, a plant that is used to treat malaria in the Amazonia region. In the search of more activity lupeol derivatives, five new 1,2,3-triazole hybrid molecules were synthetized by copper-catalyzed azide-alkyne cycloaddition. The antiplasmodial activity of the semi-synthetic compounds were evaluated by the lactate dehydrogenase assay; the lupeol propargyl ether was the only one to disclosing increased activity (half maximal inhibitory concentration-IC50-62.0 ± 1.92 µmol L-1) in relation to lupeol (IC50 117.00 µmol L-1). Therefore, this work revealed a new class of interesting lupeol derivatives that can be obtained by linking electron donors to the hydroxy group at C-3.

https://doi.org/10.21577/0103-5053.20170013 899 descargas

14.

Influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury
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Foiatto, Júlio César

; Czeczko, Nicolau Gregori

; Wietzikoski, Eduardo Gabriel Guerber

; Malafaia, Osvaldo

; Brenny Filho, Thadeu

; Oliveira, André Matos de

; Gomes, Regina de Paula Xavier

Acta Cirúrgica Brasileira

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Nov 2016, Volumen 31 Nº 11 Paginas 759 - 764

Resumen: En | Texto: En | PDF: En

ABSTRACT PURPOSE: To analyze the influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury. METHODS: Sixteen Wistar rats - split in two groups - have been used: control group, receiving 3 mg/kg isotonic saline solution through caudal vein, and, the chlorpromazine group, receiving 3 mg/kg-IV of such medication. The nephrectomy of the left kidney lower third was carried out; immediately, the test-drug was administrated. After 15 minutes of test-drug administration, the renal pedicle was clamped; in 60 minutes of ischemia it was released. After 24 hours of the renal reperfusion, the rats were, once more, anesthetized and submitted to total left nephrectomy, and, afterwards, to euthanasia. Histological findings regarding ischemia have been evaluated and compared between the groups. RESULTS: There was no statistical difference related to inferior renal pole histological analysis. Regarding 60-minute renal ischemia, chlorpromazine has statistically reduced the accrual of leucocytes within the vasa recta renis (p=0.036) and the congestion of peritubular capillaries (p=0.041). When conducting joint analysis of histological patterns, the control group showed a median score of 11 and chlorpromazine group of 5.5 (p=0.036). CONCLUSION: Chlorpromazine significantly reduced the occurrence of secondary damage to ischemia and reperfusion process in the overall histological analysis.

https://doi.org/10.1590/s0102-865020160110000009 1113 descargas

15.

Enxerto ósseo mandibular, complicações associadas às áreas doadoras e receptoras, e sobrevivência de implantes dentários: um estudo retrospectivo
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ROCHA, Julierme Ferreira

; OLIVEIRA, Júlio César Silva de

; RAMOS, José Wilson Noleto

; ARAÚJO FILHO, José Cadmo Wanderley Peregrino de

; GONÇALES, Eduardo Sanches

; HOCHULI-VIEIRA, Eduardo

; CARVALHO, Paulo Sérgio Perri de

Revista de Odontologia da UNESP

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Dic 2015, Volumen 44 Nº 6 Paginas 340 - 344

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

ResumoIntroduçãoEnxertos ósseos retirados da sínfise ou do ramo mandibular podem ser empregados para reconstrução de defeitos localizados dos maxilares, para permitir a instalação adequada de implantes dentários.ObjetivoEste estudo tem por objetivo avaliar a ocorrência de complicações associadas com as áreas doadoras e receptoras de enxerto ósseo mandibular, e a sobrevivência de implantes dentários instalados nesses sítios reconstruídos.Material e métodoAvaliaram-se 730 prontuários de pacientes submetidos a tratamento com implantes dentários. Desse universo, 72 pacientes, de ambos os gêneros, foram submetidos à reconstrução óssea com enxerto retirado da sínfise ou do ramo mandibular.ResultadoForam observadas 13 complicações e não houve diferença estatística significante quanto à ocorrência de complicações das áreas doadoras e receptoras, e da sobrevivência de implantes dentários instalados nos sítios reconstruídos com enxerto ósseo mandibular.ConclusãoOs enxertos ósseos mandibulares permitem a reconstrução de defeitos localizados dos maxilares e não são fatores de risco para a falha de implantes dentários.

AbstractIntroductionGrafts bone removed of the symphysis or mandibular ramus can be used for reconstruction located defect jaws to allow adequate installation of dental implants.ObjectiveThis study aims evaluate the occurrence of complications associated with donor and receptor sites of mandibular bone graft and survival of dental implants these reconstructed sites.Material and methodEvaluated seven hundred thirty records of patients submitted treatment with dental implants. This universe, seventy-two patients of both genders, was submitted bone reconstruction with graft removed from the symphysis or the mandibular ramus.ResultThirteen complications were observed and there was no statistically significant difference in the occurrence of complications of donor and recipient areas and survival of dental implants installed in sites reconstruction with mandibular bone graft.ConclusionThe mandibular bone grafts allow the reconstruction of defects located in jaws and don't risk factors for failure of dental implants.

https://doi.org/10.1590/1807-2577.1062 9187 descargas

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