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Abstract Background Most of the evidence about the impact of the post-acute COVID-19 Syndrome (PACS) reports individual symptoms without correlations with related imaging. Objectives To evaluate cardiopulmonary symptoms, their predictors and related images in COVID-19 patients discharged from hospital. Methods Consecutive patients who survived COVID-19 were contacted 90 days after discharge. The Clinic Outcome Team structured a questionnaire evaluating symptoms and clinical status (blinded for hospitalization data). A multivariate analysis was performed to address the course of COVID-19, comorbidities, anxiety, depression, and post-traumatic stress during hospitalization, and cardiac rehabilitation after discharge. The significance level was set at 5%. Results A total of 480 discharged patients with COVID-19 (age: 59±14 years, 67.5% males) were included; 22.3% required mechanical ventilation. The prevalence of patients with PACS-related cardiopulmonary symptoms (dyspnea, tiredness/fatigue, cough, and chest discomfort) was 16.3%. Several parameters of chest computed tomography and echocardiogram were similar in patients with and without cardiopulmonary symptoms. The multivariate analysis showed that PACS-related cardiopulmonary-symptoms were independently related to female sex (OR 3.023; 95% CI 1.319-6.929), in-hospital deep venous thrombosis (OR 13.689; 95% CI 1.069-175.304), elevated troponin I (OR 1.355; 95% CI 1.048-1.751) and C-reactive protein during hospitalization (OR 1.060; 95% CI 1.023-1.097) and depression (OR 6.110; 95% CI 2.254-16.558). Conclusion PACS-related cardiopulmonary symptoms 90 days post-discharge are common and multifactorial. Beyond thrombotic and markers of inflammation/myocardial injury during hospitalization, female sex and depression were independently associated with cardiopulmonary-related PACS. These results highlighted the need for a multifaceted approach targeting susceptible patients.

Resumo Fundamento A maioria da evidência sobre o impacto da síndrome COVID pós-aguda (PACS, do inglês, post-acute COVID-19 syndrome) descreve sintomas individuais sem correlacioná-los com exames de imagens. Objetivos Avaliar sintomas cardiopulmonares, seus preditores e imagens relacionadas em pacientes com COVID-19 após alta hospitalar. Métodos Pacientes consecutivos, que sobreviveram à COVID-19, foram contatados 90 dias após a alta hospitalar. A equipe de desfechos clínicos (cega quanto aos dados durante a internação) elaborou um questionário estruturado avaliando sintomas e estado clínico. Uma análise multivariada foi realizada abordando a evolução da COVID-19, comorbidades, ansiedade, depressão, e estresse pós-traumático durante a internação, e reabilitação cardíaca após a alta. O nível de significância usado nas análises foi de 5%. Resultados Foram incluídos 480 pacientes (idade 59±14 anos, 67,5% do sexo masculino) que receberam alta hospitalar por COVID-19; 22,3% necessitaram de ventilação mecânica. A prevalência de pacientes com sintomas cardiopulmonares relacionados à PACS (dispneia, cansaço/fadiga, tosse e desconforto no peito) foi de 16,3%. Vários parâmetros de tomografia computadorizada do tórax e de ecocardiograma foram similares entre os pacientes com e sem sintomas cardiopulmonares. A análise multivariada mostrou que sintomas cardiopulmonares foram relacionados de maneira independente com sexo feminino (OR 3,023; IC95% 1,319-6,929), trombose venosa profunda durante a internação (OR 13,689; IC95% 1,069-175,304), nível elevado de troponina (OR 1,355; IC95% 1,048-1,751) e de proteína C reativa durante a internação (OR 1,060; IC95% 1,023-1,097) e depressão (OR 6,110; IC95% 2,254-16,558). Conclusão Os sintomas cardiopulmonares relacionados à PACS 90 dias após a alta hospitalar são comuns e multifatoriais. Além dos marcadores trombóticos, inflamatórios e de lesão miocárdica durante a internação, sexo feminino e depressão foram associados independentemente com sintomas cardiopulmonares relacionados à PACS. Esses resultados destacaram a necessidade de uma abordagem multifacetada direcionada a pacientes susceptíveis.

https://doi.org/10.36660/abc.20220642

Healthcare workers exposed to COVID-19 patients present an inflammatory status and Th2/Th17/Th22 immune profile: findings from before vaccine application in Brazil
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AQUINO, RODRIGO CESAR A. DE

; BARROS, BÁRBARA RAFAELA S.

; SILVA, GUILHERME ANTONIO S.

; SOUSA, GEORON F. DE

; SOUZA, EDSON B. DE

; SILVA, DYEGO R.C.

; NASCIMENTO, ARIONE V. DO

; SÁ, IGOR W.A. DE

; LIMA, ELKER L.S. DE

; SILVA, BÁRBARA O.

; LIMA, LUÍSA P.O. DE

; VIEIRA, AMANDA M.

; BARBOSA NETO, ADAUTO G.

; MARCOS, BIANCA F. SÃO

; SILVA, ANNA JÉSSICA D.

; OLIVEIRA, TALITA HELENA ARAÚJO DE

; CARVALHO, BRUNO M.

; MUNIZ, MARIA TEREZA C.

; FREITAS, ANTONIO CARLOS DE

; CAMPELO JÚNIOR, EVÔNIO B.

; MELO, CRISTIANE M.L. DE

Anais da Academia Brasileira de Ciências

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2023, Volumen 95 Supl. 1 elocation e20220502

Resumen: En | Texto: En | PDF: En

Abstract Healthcare workers present an increased risk of contagion for the SARS-CoV-2 virus due to their labor exposure. Here, we describe the clinical, laboratory, and immunological characteristics of healthcare workers, before vaccine application, exposed to SARS-CoV-2-infected patients. We collected sociodemographic, clinical, and laboratory information from 50 professionals who worked during the COVID-19 pandemic at the Clinical Hospital of the Northwest in Brazil. The results showed that most workers are women, over 50 years old, and worked as nursing technicians. Approximately 56% of workers were positive for a previous infection by RT-PCR and/or anti-SARS-CoV-2-immunoglobulin tests. Increased levels of hematocrit, neutrophils, NK lymphocytes, and fibrinogen, were found in positive healthcare workers, suggesting a light inflammatory status. The immunological findings showed an increase in IL-17 production and a Th2/Th17/Th22 profile followed by high serology for anti-SARS-CoV-2 IgM and IgG. Those data reveal the importance of studies with healthcare workers to investigate if the continuous exposition to the virus may result in chronic activation of the immune system and/or pulmonary inflammation in this target group.

https://doi.org/10.1590/0001-3765202320220502

Wheelchair basketball improves the treatment of urinary tract infection in people with motor disabilities: a clinical trial
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Cavalcante, Ramirie N.

; Santos, Adeliana C. S.

; Rodrigues, Rosilene Andrade Silva

; Napoleão, Amanda Colichio Bini

; Balogun, Sikiru O.

; Andrade, Benedito R. M. de

; Fett, Carlos A.

; Zavala, Arturo A. Z.

; Arunachalam, Karuppusamy

; Oliveira, Ruberlei G. de

Revista da Associação Médica Brasileira

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May 2022, Volumen 68 Nº 5 Paginas 559 - 567

Resumen: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: Few studies on physical medicine and rehabilitation analyze the benefit of wheelchair basketball in people with motor disabilities. Given these, this study aimed to investigate the effect of the intervention of wheelchair basketball on urinary tract infection in people with motor disabilities. METHODS: A 12-month experimental follow-up was conducted in a single-center study. A total of 48 male individuals aged 18–55 years were allocated to the control group and experimental group. The experimental group practiced wheelchair basketball for 2 h, twice a week. Intra- and intergroup comparisons were made pre- and post-interventions over urinary tract infection. RESULTS: There was a significant improvement in urinary tract infection and urine culture in pre- and post-intervention antibiograms, respectively. Moreover, the intergroup comparison presented a decrease in infection caused by Klebsiella pneumoniae, as well as an increase in the time variability of partially activated thromboplastin, average corpuscular hemoglobin, and hemoglobin and platelets. In the experimental group, there was an increase in hemoglobin and hematocrit and a decrease in glycated hemoglobin (%HbA1C). On the intragroup comparison, there was a reduction of triiodothyronine (T3), %HbA1C, interleukin-6 pre-intervention, and C-reactive protein post-intervention. CONCLUSIONS: There was a decrease in urinary tract infection and improvement in biochemical, immunological, and microbiological biomarkers evaluated with physical exercise practice by wheelchair basketball, as well as by multiprofessional follow-up and health guidance.

https://doi.org/10.1590/1806-9282.20210896

Systematic review on efficacy of preventive measures for surgical site infection by multiple-drug resistant gram-negative bacilli
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Matos, Juliana Arruda de

; Gomes, Amanda da Silva

; Lima, Carla Ormundo G. Ximenes

; Schmaltz, Carolina Arana Stanis

; Oliveira, Cristiane Rocha de

; Silva, Grasiela Martins da

; Carijó, Júlia Herkenhoff

; Lopes, Marilena Aguiar

; Morais, Quenia Cristina Dias

; Brasil, Pedro Emmanuel Alvarenga Americano do

Brazilian Journal of Infectious Diseases

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2022, Volumen 26 Nº 6 elocation 102705

Resumen: En | Texto: En | PDF: En

ABSTRACT Background: There are no specific recommendations for prevention of surgical site infection (SSI) caused by multidrug resistant Gram-negative bacilli (MDR-GNB). Our objective was to systematically review the literature evaluating the efficacy and safety of measures specifically designed to prevent MDR-GNB SSI. Methods: We searched MEDLINE, EMBASE, CINAHL and LILACS databases up to February 18, 2020. Randomized trials and observational cohort studies evaluating the efficacy of preventive measures against MDR-GNB SSI in adult surgical patients were eligible. We evaluated methodological quality of studies and general quality of evidence using Newcastle-Ottawa scale, Cochrane ROBINS-I and GRADE method. Random-effects meta-analyses were performed using Review Manager V.5.3 software. Results: A total of 10,663 titles by searching databases were identified. Two retrospective observational studies, comparing surgical antibiotic prophylaxis (SAP) with or without aminoglycoside in renal transplantation recipients, and one non-randomized prospective study, evaluating ertapenem vs. cephalosporin plus metronidazole for SAP in extended spectrum beta-lactamase producing Enterobacteriales carriers undergoing colon surgery, were included. Risk of bias was high in all studies. Meta-analysis was performed for the renal transplantation studies, with 854 patients included. Combined relative risk (RR) for MDR GNB SSI was 0.57 (95%CI: 0.25-1.34), favoring SAP with aminoglycoside (GRADE: moderate). Conclusions: There are no sufficient data supporting specific measures against MDR-GNB SSI. Prospective, randomized studies are necessary to assess the efficacy and safety of SAP with aminoglycoside for MDR-GNB SSI prevention among renal transplantation recipients and other populations. PROSPERO 2018 CRD42018100845.

https://doi.org/10.1016/j.bjid.2022.102705

Influência do Consumo de Suco de Laranja (Citrus Sinensis) na Remodelação Cardíaca de Ratos Submetidos a Infarto do Miocárdio
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Oliveira, Bruna C.

; Santos, Priscila P.

; Figueiredo, Amanda M.

; Rafacho, Bruna P. M.

; Ishikawa, Larissa

; Zanati, Silméia G.

; Fernandes, Ana A. H.

; Azevedo, Paula S.

; Polegato, Bertha F.

; Zornoff, Leonardo A. M.

; Minicucci, Marcos F.

; Paiva, Sergio A. R.

Arquivos Brasileiros de Cardiologia

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Jun 2021, Volumen 116 Nº 6 Paginas 1127 - 1136

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento O suco de laranja (SL) é rico em polifenóis com propriedades anti-inflamatórias e antioxidantes. Após o infarto do miocárdio (IM), mudanças complexas ocorrem na estrutura e na função cardíacas, processo conhecido como remodelação cardíaca (RC). O estresse oxidativo e a inflamação podem modular esse processo. Nossa hipótese foi a de que o consumo de SL atenua a RC após o IM. Objetivos Avaliar a influência do SL sobre a RC após IM pela análise de variáveis funcionais, morfológicas, de estresse oxidativo, de inflação, e de metabolismo energético. Métodos Um total de 242 ratos machos pesando entre 200 e 250g foram submetidos a um procedimento cirúrgico (ligação da artéria coronária ou cirurgia simulada). Sete dia após a cirurgia, os animais sobreviventes foram divididos para um dos quatro grupos: 1) SM, animais sham que receberam água e maltodextrina (n= 20); 2) SSL, animais sham que receberam SL (n= 20); 3) IM, animais infartados que receberam água e maltodextrina (n= 40); e 4) ISL, animais infartados que receberam SL (n = 40). A análise estatística foi realizada pelo teste de ANOVA com dois fatores com o teste de Holm-Sidak. Os resultados foram apresentados em média ± desvio padrão, e o nível de significância adotado foi de 5%. Resultados Três meses depois, o IM levou à hipertrofia do ventrículo esquerdo (VE), com disfunção sistólica e diastólica, e aumento nos mediadores inflamatórios e de estresse oxidativo. Os animais que consumiram SL apresentaram menor atividade da glutationa peroxidase e maior expressão da heme-oxigenase-1 (HO-1). Conclusão O SL atenuou a RC, e a HO-1 pode exercer um importante papel nesse processo.

Abstract Background Orange juice (OJ) is rich in polyphenols with anti-inflammatory and antioxidant properties. After myocardial infarction (MI), complex changes occur in cardiac structure and function, which is known as cardiac remodeling (CR). Oxidative stress and inflammation can modulate this process. We hypothesized that the consumption of OJ attenuates the CR after MI. Objectives To evaluate the influence of OJ on CR after MI by analysis of functional, morphological, oxidative stress, inflammation, and energy metabolism variables. Methods A total of 242 male rats weighing 200-250 g were submitted to a surgical procedure (coronary artery ligation or simulated surgery). Seven days after surgery, survivors were assigned to one of the four groups 1) SM, sham animals with water and maltodextrin (n= 20); 2) SOJ, sham animals with OJ (n= 20); 3) IM, infarcted animals with water and maltodextrin (n= 40); and 4) IOJ, infarcted animals with OJ (n = 40). Statistical analysis was performed by the two-way ANOVA supplemented by Holm-Sidak. Results are presented as mean ± standard deviation, the level of significance adopted was 5%. Results After 3 months, MI led to left ventricular (LV) hypertrophy, with systolic and diastolic dysfunction, and increased oxidative stress and inflammatory mediators. OJ intake reduced LV cavity and improved systolic and diastolic function. The OJ animals presented lower activity of glutathione peroxidase and higher expression of heme-oxygenase-1 (HO-1). Conclusion OJ attenuated CR in infarcted rats and HO-1 may be play an important role in this process.

https://doi.org/10.36660/abc.20190397 272 descargas

Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study
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Gonçalves, Fabio Augusto Rodrigues

; Besen, Bruno Adler Maccagnan Pinheiro

; Lima, Clarice Antunes de

; Corá, Aline Pivetta

; Pereira, Antônio José Rodrigues

; Perazzio, Sandro Félix

; Gouvea, Christiane Pereira

; Fonseca, Luiz Augusto Marcondes

; Trindade, Evelinda Marramon

; Sumita, Nairo Massakazu

; Duarte, Alberto José da Silva

; Lichtenstein, Arnaldo

; Bonfa, Eloisa

; Utiyama, Edivaldo M.

; Segurado, Aluisio C.

; Perondi, Beatriz

; Miethke-Morais, Anna

; Montal, Amanda C.

; Harima, Leila

; Fusco, Solange R. G.

; Silva, Marjorie F.

; Rocha, Marcelo C.

; Marcilio, Izabel

; Rios, Izabel Cristina

; Kawano, Fabiane Yumi Ogihara

; Jesus, Maria Amélia de

; Kallas, Ésper George

; Carmo, Carolina

; Tanaka, Clarice

; Souza, Heraldo Possolo de

; Marchini, Julio F. M.

; Carvalho, Carlos

; Ferreira, Juliana C.

; Levin, Anna Sara Shafferman

; Oliveira, Maura Salaroli

; Guimarães, Thaís

; Lázari, Carolina dos Santos

; Sabino, Ester

; Magri, Marcello M. C.

; Barros-Filho, Tarcisio E. P.

; Francisco, Maria Cristina Peres Braido

; Costa, Silvia F.

Clinics

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2021, Volumen 76 elocation e3547

Resumen: En | Texto: En | PDF: En

OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and these complications can lead to a poorer prognosis. This study aimed to evaluate the association and temporal trends of D-dimer and C-reactive protein (CRP) levels with the incidence of venous thromboembolism (VTE), hospital mortality, and costs among inpatients with COVID-19. METHODS: Data were extracted from electronic patient records and laboratory databases. Crude and adjusted associations for age, sex, number of comorbidities, Sequential Organ Failure Assessment score at admission, and D-dimer or CRP logistic regression models were used to evaluate associations. RESULTS: Between March and June 2020, COVID-19 was documented in 3,254 inpatients. The D-dimer level ≥4,000 ng/mL fibrinogen equivalent unit (FEU) mortality odds ratio (OR) was 4.48 (adjusted OR: 1.97). The CRP level ≥220 mg/dL OR for death was 7.73 (adjusted OR: 3.93). The D-dimer level ≥4,000 ng/mL FEU VTE OR was 3.96 (adjusted OR: 3.26). The CRP level ≥220 mg/dL OR for VTE was 2.71 (adjusted OR: 1.92). All these analyses were statistically significant (p<0.001). Stratified hospital costs demonstrated a dose-response pattern. Adjusted D-dimer and CRP levels were associated with higher mortality and doubled hospital costs. In the first week, elevated D-dimer levels predicted VTE occurrence and systemic inflammatory harm, while CRP was a hospital mortality predictor. CONCLUSION: D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.

https://doi.org/10.6061/clinics/2021/e3547

Avaliação do kit Filaria Detect™ IgG4 produzido com o antígeno recombinante Wb123 para diagnóstico da filariose linfática no Brasil
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Melo, Paula Fernanda A. S.

; Silva, Maria Almerice L.

; Oliveira, Maria Rosângela G.

; Araújo, Josué

; Fernandes, Amanda

; Diniz, George Tadeu N.

; Brandão, Eduardo

; Rocha, Abraham

; Maciel, Maria Amélia

Revista Panamericana de Salud Pública

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2021, Volumen 45 elocation e87

Resumen: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO O Plano Global de Eliminação da Filariose Linfática, lançado pela Organização Mundial da Saúde em 2000, propõe o uso de testes de detecção de antígeno circulante filarial como ferramenta diagnóstica para avaliação e monitoramento das ações de controle da parasitose. Entretanto, esses testes, apesar de apresentarem alta sensibilidade, não conseguem detectar com eficiência a infecção em seu estágio inicial, quando ainda não existe a presença de helmintos adultos. Considerando essa limitação, a pesquisa de anticorpos antifilariais tem sido apontada como uma alternativa, uma vez que os anticorpos produzidos contra as larvas infectantes do parasito são detectados antes da presença de antígeno circulante filarial. O objetivo deste estudo foi definir o ponto de corte e avaliar a acurácia do kit Filaria Detect™ IgG4 produzido com o antígeno recombinante Wb123 para diagnóstico da filariose linfática no Brasil. Para isso, foi realizado um estudo de avaliação de teste diagnóstico, no qual foram utilizadas 256 amostras de soro: 79 (30,9%) obtidas de indivíduos microfilarêmicos e 177 (60,1%), de indivíduos amicrofilarêmicos e que testaram negativo para os testes imunológicos Bm14 CELISA e Og4C3 ELISA. A definição do ponto de corte ideal, bem como da acurácia do kit Filaria Detect™ IgG4, foi obtida através da construção de curvas ROC, sendo a densidade óptica de 0,239 aquela na qual o teste obteve melhor desempenho, com sensibilidade de 81,0% e especificidade de 96,6%. Os resultados obtidos demonstraram que o kit Filaria Detect™ IgG4 é uma ferramenta promissora para investigação e monitoramento de áreas submetidas ao tratamento em massa para filariose linfática.

ABSTRACT The Global Programme to Eliminate Lymphatic Filariasis, launched by the World Health Organization in the year 2000, proposes the use of circulating filarial antigen tests as a diagnostic tool to assess and monitor initiatives to control filarial infection. However, despite a high sensitivity, these tests are not efficient to detect infection at early stages, before worms have reached the adult stage. Considering this limitation, anti-filarial antibody testing has been suggested as an alternative, given that the antibodies produced against the larvae are detectable before the presence of circulating filarial antigen. The objective of the present study was to determine the diagnostic cut-off and the accuracy of the Filaria Detect™ IgG4 kit employing recombinant Wb123 antigen for diagnosis of lymphatic filariasis in Brazil. For that, we performed a diagnostic evaluation study in which 256 serum samples were analyzed: 79 (30.9%) obtained from microfilaremic individuals and 177 (60.1%) from amicrofilaremic individuals who tested negative with the Bm14 CELISA and Og4C3 ELISA immunologic tests. The ideal cutoff as well as the Filaria Detect™ IgG4 kit accuracy were determined based on ROC curve analyses, with an optical density of 0.239 identified as the cutoff with the best performance, with 81.0% sensitivity and 96.6% specificity. The results show that the Filaria Detect™ IgG4 kit is a promising tool for investigation and monitoring of areas undergoing mass drug administration for lymphatic filariasis.

RESUMEN En el programa mundial de eliminación de la filariasis linfática, puesto en marcha por la Organización Mundial de la Salud en el año 2000, se propone el uso de pruebas de detección del antígeno filárico circulante como instrumento de diagnóstico para la evaluación y el seguimiento de las medidas de control de la parasitosis. Sin embargo, esas pruebas, a pesar de tener un alto grado de sensibilidad, no permiten detectar con eficiencia la infección en su fase inicial, cuando todavía no existen helmintos adultos. En vista de esa limitación, se ha señalado como una opción el estudio de anticuerpos antifiláricos, puesto que los anticuerpos producidos contra las larvas infectantes del parásito se detectan antes de la existencia de antígeno filárico circulante. El objetivo de este estudio fue definir el punto de corte y evaluar la exactitud del estuche Detect™ para pruebas de anticuerpos antifiláricos IgG4, fabricado con el antígeno recombinante Wb123, para el diagnóstico de la filariasis linfática en Brasil. Para ello, se realizó un estudio de evaluación de la prueba diagnóstica, en el cual se utilizaron 256 muestras de suero, a saber, 79 (30,9%) obtenidas de personas microfilarémicas y 177 (60,1%) de personas amicrofilarémicas, que arrojaron resultados seronegativos en las pruebas inmunológicas CELISA Bm14 y ELISA Og4C3. La definición del punto de corte ideal y de la exactitud del estuche Detect™ se obtuvo con la construcción de curvas de la característica operativa del receptor (ROC); una densidad óptica de 0,239 marcó el mejor nivel de desempeño de la prueba, con una sensibilidad de 81,0% y una especificidad de 96,6%. Los resultados obtenidos demostraron que el estuche Detect™ es un instrumento prometedor para la investigación y el seguimiento de las regiones donde se realiza un tratamiento masivo de la filariasis linfática.

https://doi.org/10.26633/rpsp.2021.87

Production of Bambusa vulgaris seedlings from rhizomes under brackish water irrigation
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Branco, Lourenço M. C.

; Lacerda, Claudivan F. de

; Marinho, Albanise B.

; Sousa, Carlos H. C. de

; Calvet, Amanda S. F.

; Oliveira, Erasto G. de

Revista Brasileira de Engenharia Agrícola e Ambiental

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May 2020, Volumen 24 Nº 5 Paginas 337 - 342

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivou-se com este trabalho avaliar a influência da irrigação com água salobra na produção de mudas de bambu (Bambusa vulgaris). O experimento foi desenvolvido na Fazenda Experimental Piroás (4° 14’ 53” S, 38° 45’ 10” W, e altitude de 230 m), no município de Redenção, Ceará, no delineamento inteiramente casualizado, com seis repetições. Os tratamentos foram constituídos de cinco condutividades elétricas da água de irrigação (CEa): 0,5 (testemunha); 1,5; 2,5; 3,5 e 4,5 dS m-1. Aos 120 dias após o início da aplicação dos tratamentos foram avaliadas: trocas gasosas foliares, índice relativo de clorofila (IRC), altura das plantas (H), produção de biomassa seca da parte aérea (MSPA), relação H/MSPA e teores de sódio e potássio nos caules e folhas. Com os dados de MSPA, H, fotossíntese e IRC foram calculados os índices de tolerância à salinidade. O incremento na CEa reduziu as trocas gasosas foliares, sendo a redução na taxa de fotossíntese provocada por causas estomáticas e não estomáticas. A salinidade afetou negativamente o crescimento e a qualidade das mudas de bambu, sendo os efeitos mais expressivos com valores de CEa iguais ou superiores a 2,5 dS m-1. Mudas de bambu apresentam retenção de Na+ nos caules e baixa relação Na+/K+ nas folhas. As mudas de bambu são tolerantes à salinidade até 1,5 dS m-1, sendo um indicativo que águas com esta salinidade podem ser utilizadas na produção de mudas desta espécie, sem perdas de crescimento e de qualidade.

ABSTRACT The objective of this study was to evaluate the influence of irrigation with brackish water on the production of bamboo seedlings (Bambusa vulgaris). The experiment was carried out at the Fazenda Experimental Piroás, in the municipality of Redenção, CE, Brazil (4° 14’ 53” S, 38° 45’ 10” W, and altitude of 230 m), in a completely randomized design with five treatments and six repetitions. The treatments consisted of five irrigation water electrical conductivity (ECw): 0.5 (control); 1.5; 2.5; 3.5 and 4.5 dS m-1. At 120 days after the beginning of the application of the treatments the leaf gas exchange, relative chlorophyll index (RCI), plant height (H), shoot dry matter (SDM), H/SDM ratio, and the concentrations of Na+ and K+ in stems and leaves were evaluated. Salt tolerance indexes were calculated based on SDM, H, photosynthesis rate and RCI. The increase in the ECw reduced leaf gas exchange, and the reduction in the photosynthesis rate was caused by stomatal and non-stomatal effects. The salinity affected negatively the growth and quality of bamboo seedlings, with the greatest effects being with ECw equal to or greater than 2.5 dS m-1. Bamboo seedlings present Na+ retention in the stems and low Na+/K+ ratio in the leaves. Bamboo seedlings are tolerant to salinity up to 1.5 dS m-1, indicating that waters with this salinity can be used for seedling production of this species, without loss of growth and quality.

https://doi.org/10.1590/1807-1929/agriambi.v24n5p337-342 447 descargas

Encounter rate and behavior of Alouatta guariba clamitans in the Ilha Grande State Park, Rio de Janeiro state, Brazil
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Ferreguetti, Atilla C.

; Oliveira, Amanda B.M. de

; Pereira, Bruno C.

; Santori, Ricardo T.

; Geise, Lena

; Bergallo, Helena G.

Zoologia (Curitiba)

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2020, Volumen 37 elocation e36846

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ABSTRACT Alouatta guariba clamitans Cabrera, 1940 is an endemic species of the Atlantic Forest that occurs from south Bahia, Brazil, extending south to the province of Misiones, Argentina. In Rio de Janeiro state, the species was classified as threatened, indicating that attention is needed for the conservation of this taxon. Additionally, an outbreak of yellow fever spread throughout the southeastern states of Brazil from January 2017 until March 2018 seriously threatening Rio de Janeiro populations of the species. Herein, we aimed to provide the first estimates of A. g. clamitans encounter rate, density, and population size in the Ilha Grande State Park (PEIG), which is part of the Atlantic Forest biome of Brazil. Data were collected in two different periods, the first between December 2003 and May 2005, and the second from August 2009 to May 2010, and information on encounter rates and behavior was collected to better understand aspects of species’ ecology. The estimated encounter rate in the first period through the distance sampling method was 0.04 ± 0.01 individuals per kilometer. Nine groups were recorded in the second period of the study, with 47 individuals along 3 km. Our estimates of encounter rate, density and population size were low and reinforces the need to initiate species monitoring and assess the impact that yellow fever outbreaks may have on PEIG populations. The results presented here can be a starting point to support future strategic actions for the species, to measure impacts and to the management of the species, and for a conservation program.

https://doi.org/10.3897/zoologia.37.e36846 706 descargas

10.

O consumo de bebida alcoólica e o binge drink entre os graduandos de Medicina de uma Universidade de Minas Gerais
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Abreu, Thalles Trindade de

; Maurílio, Amanda de Oliveira

; Liguori, Caio César

; Tavares, Daniel Vasconcelos de Pinho

; Terceiro, Delmo Manoel Gomes

; Cunha, Lucas G. Malta

; Belo, Vinícius Silva

; Silva, Alexandre Ernesto

Jornal Brasileiro de Psiquiatria

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Jun 2018, Volumen 67 Nº 2 Paginas 87 - 93

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RESUMO Objetivos O estudo objetivou verificar o padrão de consumo de bebidas alcoólicas e a presença do beber pesado episódico (BPE) entre os estudantes de Medicina de uma universidade do centro-oeste de Minas Gerais. Métodos Trata-se de um estudo transversal, exploratório e descritivo, realizado com 202 graduandos do curso de Medicina de uma universidade do centro-oeste de Minas Gerais. A coleta de dados foi realizada no primeiro semestre de 2015, com a utilização de um questionário sociodemográfico e do questionário Audit. O tratamento estatístico dos dados foi realizado com a utilização da análise bivariada, por meio do teste qui-quadrado ou do teste de Fisher e de modelos multivariados de regressão logística. Resultados Observou-se que o álcool é utilizado por 76,6% dos estudantes pesquisados, e 53,7% praticavam o BPE. O consumo de bebidas alcoólicas teve associação significativa com a idade e o fato de não morar com a família e estar acima do terceiro ano de graduação. O BPE, por sua vez, esteve associado com o sexo masculino e com o fato de não morar com a família. Conclusões Este trabalho mostrou que o consumo de álcool entre os estudantes de Medicina é maior do que o da população geral e que a prática do BPE possui alta prevalência nesse grupo. Idade, não morar com a família e período mais avançado do curso foram associados a maior consumo de álcool. Ser do sexo masculino e não morar com a família se associaram a maior risco de BPE.

ABSTRACT Objectives The study had as its goal to verify the pattern of the alcoholic beverages consumption and the presence of drinking heavily snatchy (BPE) among the Medicine students of a Minas Gerais Midwest university. Methods It is about a transversal, exploratory and descriptive study, performed on 202 graduating students of the Medicine course of a Minas Gerais Midwest university. The data collet was performed on the first term of 2015, a sociodemographic questionnaire and the Audit questionnaire were used. The statistical treatment of the data was performed with the use of the bivariate analysis, through the chi-square test or by the Fisher test, and multivariate logistic regression models. Results It was noticed that the alcohol is used by 76,6% of the students surveyed, being that 53,7% practiced the drinking heavily episodic. The alcoholic beverages consumption had meaningful association with the age, not living with family and being above the 3rd year of graduation. Drinking heavily episodic had meaningful association with the males and not living with family. Conclusions This paperwork has shown that the alcohol consumption among Medicine students is bigger than among the general population and the binge drink practice has high prevalence on that group. Age, not living with the family and more advanced period of the course were associated with higher alcohol consumption. Being male and not living with the family were associated with a higher risk of BPE.

https://doi.org/10.1590/0047-2085000000190 3302 descargas

11.

Cytopathologic follow-up of women with cervical cancer post-radiotherapy: case series
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Silva, Ruan Carlos G.

; Figueirêdo, Rachel Di Paola V.

; Silva, Amanda Cristina O.

; Lima, Carlos Eduardo Q.

; Oliveira, Sibele R.

; Peres, Adrya Lúcia

Jornal Brasileiro de Patologia e Medicina Laboratorial

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Abr 2018, Volumen 54 Nº 2 Paginas 99 - 104

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A citopatologia, além de seu papel nos programas de rastreio do câncer cervical, é uma importante ferramenta para o controle da eficácia do tratamento em mulheres com câncer de colo do útero, monitorando e detectando precocemente neoplasias residuais, recorrentes ou alterações reacionais benignas. Neste trabalho, relatamos oito casos de citopatologia de seguimento em mulheres com câncer de colo do útero após tratamento radioterápico, assistidas por um centro de oncologia pernambucano. Os principais achados citológicos pós-tratamento foram descritos, assim como as características histopatológicas ao diagnóstico e os tratamentos realizados.

ABSTRACT Cytopathology, in addition to its role in cervical cancer screening programs, is also an important tool for controlling the efficacy of treatment in women with cervical cancer by monitoring and early detecting residual, recurrent neoplasms or benign reactive changes. In this study, we report eight cases of cytopathologic follow-up of women with cervical cancer post-radiotherapy, assisted by a Center of Oncology in Pernambuco. The main cytological findings post-treatment were described,as well as the histopathological characteristics at diagnosis and the treatments performed.

https://doi.org/10.5935/1676-2444.20180018 2614 descargas

12.

Clindamycin microbial resistance in clinical isolates of Staphylococcus sp. derived from blood cultures of hospitalized patients
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Silva, Amanda Cristina O.

; Silva, Ruan Carlos G.

; Oliveira, Sibele R.

Jornal Brasileiro de Patologia e Medicina Laboratorial

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Jun 2016, Volumen 52 Nº 3 Paginas 165 - 170

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: As infecções causadas por cepas de Staphylococcus aureus resistente à meticilina (MRSA) tornaram-se comuns no âmbito hospitalar, e essa resistência limitou o tratamento dos pacientes com antibióticos betalactâmicos. A clindamicina é um importante agente terapêutico para as infecções por MRSA, porém a resistência a macrolídeos, lincosamida e estreptogramina B (MLSB) induzível (iMLSB) tem conferido falhas terapêuticas ao uso desse antimicrobiano, com consequente aumento da mortalidade e do tempo de internação dos pacientes. Objetivo: Este estudo foi realizado com o propósito de detectar fenótipos de resistência constitutiva e induzível à clindamicina em amostras de hemoculturas do gênero Staphylococcus sp. de pacientes internados. Material e métodos: Foram analisadas 100 amostras bacterianas provenientes de hemoculturas de pacientes adultos, as quais foram identificadas por testes fenotípicos convencionais e submetidas à determinação do perfil de sensibilidade e resistência com discos de cefoxitina, eritromicina e clindamicina e à pesquisa fenotípica de resistência iMLSB pelo D-teste. Os resultados foram interpretados de acordo com as recomendações do Clinical and Laboratory Standards Institute (CLSI) 2014. Resultados: Neste estudo, 65% das 60 amostras bacterianas foram sensíveis à cefoxitina e 35%, resistentes. O fenótipo de resistência MLSB constituído (cMLSB) foi observado em 15,56% das amostras de methicillin-sensitive Staphylococcus aureus (MSSA), 33,33% de methicillin-sensitive coagulase-negative Staphylococcus (MSCONS), 26,67% de MRSA e 20% de methicillin-resistant coagulase-negative Staphylococcus (MRCONS), enquanto a resistência iMLSB foi verificada apenas em isolados sensíveis à cefoxitina, correspondendo a 80% em MSSA e 20% em MSCONS. Conclusão: O D-teste é um teste essencial para o monitoramento constante do iMLSB (que pode comprometer a eficácia do tratamento com clindamicina), minimizando possíveis erros terapêuticos e desfechos clínicos desfavoráveis.

ABSTRACT Introduction: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) strains have become common in hospitals, and this resistance has limited patients' treatment with beta-lactam antibiotics. Clindamycin is an important therapeutic agent for MRSA infections; however, inducible macrolide-lincosamide-streptogramin B (MLSB) resistance (iMLSB) has resulted in therapeutic failures with the use of this antimicrobial, with a consequent increase in patient mortality and length of stay. Objective: This study was carried out in order to detect phenotypes of inducible and constitutive resistance to clindamycin in blood culture samples of Staphylococcus sp. from hospitalized patients. Material and methods: A hundred bacterial samples from blood cultures of adult patients were evaluated, identified by conventional phenotypic tests, and subject to determination of susceptibility and resistance profiles with cefoxitin, erythromycin, and clindamycin discs; and to phenotypic evaluation of iMLSB resistance using the D-test. The results were interpreted in accordance with the recommendations of the Clinical and Laboratory Standards Institute (CLSI) 2014. Results: In this study, 65% of 60 bacterial strains were susceptible to cefoxitin and 35%, resistant. The constitutive MLSB (cMLSB) resistance phenotype was observed in 15.56% of the methicillin-sensitive Staphylococcus aureus (MSSA) samples, 33.33% of methicillin-sensitive coagulase-negative Staphylococcus (MSCONS), 26.67% of MRSA and 20% of methicillin-resistant coagulase-negative Staphylococcus (MRCONS), while iMLSB resistance was observed only in strains susceptible to cefoxitin, corresponding to 80% in MSSA and 20% in MSCONS. Conclusion: The D-test is a key test for the constant monitoring of the inducible resistance phenotype (which may impair the effectiveness of treatment with clindamycin), minimizing potential medication errors and adverse clinical outcomes.

https://doi.org/10.5935/1676-2444.20160024 1911 descargas

13.

Atividade moduladora de extratos etanólico das folhas de Clusia nemorosa G. Mey. (Clusiaceae) sobre drogas antimicrobianas
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Honorio de Oliveira, Alison

; Oliveira Andrade, Amanda

; Cortez Sombra Vandesmet, Lilian

; Pessoa da Silva, Maria Arlene

; Melo Coutinho, Henrique Douglas

; Figueiredos dos Santos, Marcos Aurélio

Revista Cubana de Plantas Medicinales

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Mar 2016, Volumen 21 Nº 1 Paginas 1 - 8

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14.

ESTUDO FITOQUÍMICO, ATIVIDADE ANTIMICROBIANA E CITOTÓXICA DE ESPÉCIMES DE Leonotis nepetifolia L. R. (Br)
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Oliveira, Ana P.

; Guimarães, Amanda L.

; Pacheco, Alessandra G. M.

; Araújo, Camila S.

; Oliveira Júnior, Raimundo G.

; Lavor, Érica M.

; Silva, Mariana G.

; Araújo, Edigênia C. C.

; Mendes, Rosemairy L.

; Rolim, Larissa A.

; Costa, Marcília P.

; Farias, Henrique C. L.

; Pessoa, Cláudia do Ó

; Lopes, Norberto P.

; Marques, Lucas M. M.

; Almeida, Jackson R. G. S.

Química Nova

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Ene 2016, Volumen 39 Nº 1 Paginas 32 - 37

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Specimens of Leonotis nepetiflolia were obtained from cultivated and wild environments to verify their influences in chemical composition. Phytochemical analyses were conducted for the ethyl acetate phase obtained by partitioning the crude ethanol extract from the cultivated leaves of L. nepetifolia. In doing so, flavonoid 3',4',5-trimethoxy-6,7-dihidroxyflavone (cirsiliol), a chemotaxonomic marker of the family Lamiaceae, was isolated. The results reveal that all phases and extracts tested exhibited weak to moderate antimicrobial activity against the strains of bacteria tested. The evaluation of in vitrocytotoxic and antitumor activity showed that the ethyl acetate phases obtained from both wild and cultivated leaves exhibit high potential cytotoxic and antitumor (> 78.0% of inhibition) activity. The major component of these phases was identified by high-performance liquid chromatography-diode array detector and nuclear magnetic resonance analyses using both 1D and 2D methods. The results further indicate that the flavonoid cirsiliol is the agent responsible for the activity observed in these phases.

https://doi.org/10.5935/0100-4042.20150160 2707 descargas

15.

Binary Micellar Solutions of Poly(Ethylene Oxide)-Poly(Styrene Oxide) Copolymers with Pluronic® P123: Drug Solubilisation and Cytotoxicity Studies
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Oliveira, Samira A.

; Moura, Carolina L.

; Cavalcante, Igor M.

; Lopes, Amanda Araújo

; Leal, Luzia K. A. M.

; Gramosa, Nilce V.

; Ribeiro, Maria E. N. P.

; França, Francisco C. F.

; Yeates, Stephen G.

; Ricardo, Nágila M. P. S.

Journal of the Brazilian Chemical Society

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Nov 2015, Volumen 26 Nº 11 Paginas 2195 - 2204

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The non-commercial copolymers E45S8, E45S17 and their mixtures with Pluronic® P123 (E21P67E21) were studied as carriers of the model drug griseofulvin. Critical micelle concentration (cmc) (dye solubilisation method), drug solubilisation capacity (Scp and Sh) determined by ultraviolet-visible (UV-Vis) spectroscopy and 1H nuclear magnetic resonance (1H NMR) and cytotoxicity (LDH activity in human neutrophils) were studied. E45S17 1.0 wt.% dispersions presented colloidal aggregates limiting its Scp in comparison to E45S8, but in 0.1 wt.% solutions this phenomenon seemed to be absent and E45S17 presented a higher Scp. The mixtures that showed the best Scp results contained 50% of P123 and presented low cmc. An evaluation of literature data suggested a minimum Em content of 62% in EmSn copolymers below which the increase of Sn length does not lead to an increase of Sh. The results suggested no toxicity of the copolymers on human neutrophils, supporting the use of P123 and poly(styrene oxide) containing copolymers as drug carriers.

https://doi.org/10.5935/0103-5053.20150205 1201 descargas

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