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Abstract ‘BRS Tainá’ is a new seedless table grape cultivar developed and recommended for the Submedium of São Francisco Valley, the main producing and exporting region of table grapes in Brazil. The objective of this study was to evaluate the influence of rootstock on vigor, bud fertility, sucrose and total soluble carbohydrates content in leaves of ‘BRS Tainá’ vine cultivated in semi-arid environmental conditions in the Brazilian Northeast. The treatments were represented by eight rootstocks: ‘101-14 MgT’, ‘IAC 313’, ‘IAC 572’, ‘IAC 766’, ‘Paulsen 1103’, ‘Ramsey’, ‘SO4’ and ‘Teleki 5C’. The experimental design was in randomized blocks with four replications, in split plots, the production cycles were considered as plots, and eight rootstocks as subplots. The following variables were evaluated: pruning weight, stem diameter, number of lateral bunches, bud fertility, sucrose and total soluble carbohydrates content in leaves. The ‘BRS Tainá’ vine had moderate canopy vigor and 54% of bud fertility. The carbohydrate content and sucrose in the leaves did not differ among treatments during pruning. Therefore, it is possible that there is no effect of the rootstock on the initial vegetative growth of ‘BRS Tainá’ vines, which vigor and bud fertility remained stable in the initial production cycles.

Resumo ‘BRS Tainá’ é uma nova cultivar de uvas de mesa sem sementes desenvolvida e recomendada para o Vale do Submédio São Francisco, principal região produtora e exportadora de uvas finas no Brasil. O objetivo deste trabalho foi avaliar a influência do porta-enxerto sobre o vigor, a fertilidade de gemas e o conteúdo de sacarose e carboidratos solúveis totais nas folhas de videiras ‘BRS Tainá’, cultivadas em condições semiáridas do Nordeste brasileiro. Os tratamentos foram constituídos por oito porta-enxertos: ‘101-14 MgT’, ‘IAC 313’, ‘IAC 572’, ‘IAC 766’, ‘Paulsen 1103’, ‘Ramsey’, ‘SO4’ e ‘Teleki 5C’. O delineamento experimental foi em blocos casualizados, em parcelas subdivididas, com quatro repetições, sendo os ciclos de produção considerados como parcelas, e os oito porta-enxertos, como subparcelas. As seguintes variáveis foram avaliadas: massa fresca de ramos e folhas, diâmetro de caule, número de saídas laterais, índice de fertilidade de gemas, conteúdo de sacarose e carboidrato nas folhas. A videira ‘BRS Tainá’ apresentou vigor da copa moderado e fertilidade de gemas em 54%. O conteúdo de carboidratos solúveis totais e de sacarose nas folhas não diferiu entre os porta-enxertos durante a poda de produção. Logo, é possível inferir que não houve influência do porta-enxerto no desenvolvimento vegetativo inicial de videiras ‘BRS Tainá’, visto que apresentam estabilidade no vigor e fertilidade de gemas nos primeiros ciclos de produção.

https://doi.org/10.1590/0100-29452023103

Atualização da Recomendação para Avaliação da Doença das Artérias Carótidas e Vertebrais pela Ultrassonografia Vascular: DIC, CBR, SBACV – 2023
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Albricker, Ana Cristina Lopes

; Freire, Claudia Maria Vilas

; Santos, Simone Nascimento dos

; Alcantara, Monica Luiza de

; Cantisano, Armando Luis

; Porto, Carmen Lucia Lascasas

; Amaral, Salomon Israel do

; Veloso, Orlando Carlos Glória

; Morais Filho, Domingos de

; Teodoro, José Aldo Ribeiro

; Petisco, Ana Cláudia Gomes Pereira

; Saleh, Mohamed Hassan

; Barros, Marcio Vinícius Lins de

; Barros, Fanilda Souto

; Engelhorn, Ana Luiza Dias Valiente

; Engelhorn, Carlos Alberto

; Nardino, Érica Patrício

; Silva, Melissa Andreia de Moares

; Biagioni, Luisa Ciucci

; Souza, Adriano José de

; Sarpe, Anna Karina Paiva

; Oliveira, Arthur Curtarelli de

; Moraes, Marcelo Rodrigo de Souza

; Francisco Neto, Miguel José

; Françolin, Peter Célio

; Rochitte, Carlos Eduardo

; Iquizli, Rogerio

; Santos, Alair Augusto Sarmet Moreira Damas dos

; Muglia, Valdair Francisco

; Naves, Bruno de Lima

Arquivos Brasileiros de Cardiologia

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2023, Volumen 120 Nº 10 elocation e20230695

Resumen: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230695

Career commitment and career entrenchment among Primary Health Care workers
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Lourenção, Luciano Garcia

; Oliveira, Jacqueline Flores de

; Ximenes Neto, Francisco Rosemiro Guimarães

; Cunha, Carlos Leonardo Figueiredo

; Valenzuela-Suazo, Sandra Verónica

; Borges, Márcio Andrade

; Gazetta, Cláudia Eli

Revista Brasileira de Enfermagem

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2022, Volumen 75 Nº 1 elocation e20200144

Resumen: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Avaliar os níveis de comprometimento e entrincheiramento com a carreira de trabalhadores da Atenção Primária à Saúde. Métodos: Estudo transversal com 393 trabalhadores, utilizando as versões brasileiras das Escalas de Comprometimento com a Carreira (ECC) e de Entrincheiramento na Carreira (EEC). Resultados: Os níveis de Comprometimento [75,5 - 77,5] foram superiores (p<0,001) aos de Entrincheiramento [66,7 - 69,2]. Os níveis de Identidade [82,7 - 85,5] foram superiores (p<0,001) aos níveis de Investimentos [60,4 - 65,0]. Os níveis de Resiliência com a carreira [75,1 - 79,2] foram superiores (p<0,001) aos níveis de Custos emocionais com a carreira [69,0 - 72,1]. Os níveis de Planejamento [64,2 - 67,1] foram inferiores (p<0,001) aos níveis de Limitação de alternativas [68,1 - 71,0]. Conclusão: Predominou o vínculo de comprometimento com a carreira, evidenciando identificação e relação positiva dos trabalhadores com a carreira, os quais permanecem na Atenção Primária à Saúde porque se identificam com a profissão.

ABSTRACT Objective: Assess levels of career commitment and career entrenchment among Primary Health Care workers. Methods: This Cross-sectional study addressed 393 workers using the Brazilian versions of the Career Commitment Measure (CCM) and Career Entrenchment Measure (CEM). Results: Levels of Career commitment [75.5-77.5] were higher (p<0.001) than Career Entrenchment [66.7-69.2]. Identity levels [82.7-85.5] were higher (p<0.001) than Investment levels [60.4-65.0]. Career resilience levels [75.1-79.2] were higher (p<0.001) than Emotional costs [69.0-72.1]. Planning levels [64.2-67.1] were lower (p<0.001) than levels of limitedness of career alternatives [68.1-71.0]. Conclusion: The highest scores were obtained in Career commitment, showing the workers’ identification and positive relationship with their careers, that is, these workers remain in Primary Health Care services because they identify themselves with their professions.

RESUMEN Objetivo: Evaluar los niveles de compromiso y afianzamiento con la carrera del personal de la Atención Primaria de Salud. Métodos: Se trata de un estudio transversal, realizado entre 393 trabajadores, en el que se utilizaron las versiones brasileras de las Escalas de Compromiso con la Carrera (ECC) y de Afianzamiento con la Carrera (EEC). Resultados: Los niveles de Compromiso [75,5 - 77,5] eran superiores (p<0,001) a los de Afianzamiento [66,7 - 69,2]. Los niveles de Identidad [82,7 - 85,5] eran superiores (p<0,001) a los de Inversión [60,4 - 65,0]. Los niveles de Resiliencia con la carrera [75,1 - 79,2] eran superiores (p<0,001) a los de Costo emocional [69,0 - 72,1]. Los niveles de Planificación [64,2 - 67,1] eran inferiores (p<0,001) a los de Limitación de alternativas [68,1 - 71,0]. Conclusión: Predominó el vínculo de compromiso con la carrera, lo que demuestra una identificación y relación positiva de los trabajadores con la misma y permanecen en la Atención Primaria de Salud porque se identifican con la profesión.

https://doi.org/10.1590/0034-7167-2021-0144 312 descargas

Occurrence of tick-borne pathogens in dogs in a coastal region of the state of Ceará, northeastern Brazil
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Fonsêca, Arícia Débora Vasconcelos

; Oliveira, Lorena Mayana Beserra de

; Jorge, Felipe Rodrigues

; Cavalcante, Ramuelly Olinda

; Bevilaqua, Claudia Maria Leal

; Pinto, Francisco José Maia

; Santos, Jessica Maria Leite dos

; Teixeira, Bruno Marques

; Rodrigues, Ana Kétylla Ponte Prado

; Braz, Gissandra Farias

; Viana, Geysa Almeida

; Costa, Edmara Chaves

; Serpa, Maria Carolina de Azevedo

; Weck, Bárbara Conte

; Labruna, Marcelo Bahia

Revista Brasileira de Parasitologia Veterinária

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2022, Volumen 31 Nº 1 elocation e021321

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste estudo foi determinar a ocorrência de patógenos transmitidos por carrapatos (Ehrlichia canis, Babesia vogeli, Hepatozoon spp. e Rickettsia spp.) em cães na Vila de Jericoacoara, região costeira do Ceará, Brasil. Amostras de sangue foram coletadas de 153 animais e analisadas por métodos moleculares e sorológicos. Sessenta animais foram encontrados infectados ou expostos a pelo menos a um dos patógenos estudados. Babesia vogeli foi o patógeno mais prevalente (15%), seguido por E. canis (13,7%) e Hepatozoon spp. (11,8%), que foi identificado como Hepatozoon canis por sequenciamento. Vinte cães (13%) foram sororreativos à Rickettsia spp. Rhipicephalus sanguineus sensu lato foi observado em 11,8% dos animais. Houve associações entre idade (<3 anos) e positividade para B. vogeli, e entre habitação (cães de rua) e positividade para H. canis. Também houve associações entre anemia e infecção por H. canis, e entre leucopenia e exposição a Rickettsia spp. Não foi detectada associação entre alterações clínicas e infecção ou exposição aos patógenos estudados. Os resultados confirmaram que patógenos de importância veterinária estão circulando no nordeste do Brasil e mostraram que cães estão expostos a espécies de Rickettsia com potencial zoonótico, indicando a necessidade de medidas de controle do vetor.

Abstract The aim of this study was to determine the occurrence of tick-borne pathogens (Ehrlichia canis, Babesia vogeli, Hepatozoon spp. and Rickettsia spp.) in dogs in Vila de Jericoacoara, coastal region of Ceará, Brazil. Blood samples were collected from 153 animals and analyzed using molecular and serological methods. Sixty animals were found to be infected or exposed to at least one of the pathogens studied. Babesia vogeli was the most prevalent pathogen (15%), followed by E. canis (13.7%) and Hepatozoon spp. (11.8%), which was identified as Hepatozoon canis through sequencing. Twenty dogs (13%) were seroreactive to Rickettsia spp. Rhipicephalus sanguineus sensu lato was observed on 11.8% of the animals. There were associations between age (< 3 years old) and positivity for B. vogeli, and between habitation (stray dogs) and positivity for H. canis. There were also associations between anemia and infection with H. canis, and between leukopenia and exposure to Rickettsia spp. No association was detected between clinical alterations and infection with or exposure to the pathogens studied. The results confirmed that pathogens of veterinary importance are circulating in northeastern Brazil and showed that dogs are exposed to Rickettsia species with zoonotic potential, thus indicating a need for vector control measures.

https://doi.org/10.1590/s1984-29612022010

Anticandidal Activity of Hydroalcoholic Extract of Phyllanthus niruri L. (Stone-Breaker)
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Maia, Flávia Camila

; Wijesinghe, Gayan Kanchana

; Barbosa, Janaína Priscila

; Feiria, Simone Nataly Busato de

; Oliveira, Thais Rossini

; Boni, Giovana Claudia

; Jóia, Felipe

; Cardoso, Vanessa da Silva

; Franco, Valéria Alessandra Prado Defávari

; Anibal, Paula Cristina

; Höfling, José Francisco

Brazilian Archives of Biology and Technology

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2022, Volumen 65 elocation e22210539

Resumen: En | Texto: En | PDF: En

Abstract Candida is becoming more resistant to conventional treatments, and causes persistent and severe infections. This study evaluates the antifungal and virulence activities of the hydroalcoholic extract of Phyllanthus niruri (HE-Pn) on Candida. HE-Pn was prepared by maceration technique. Chemical composition of HE-Pn was determined using Gas Chromatography-Mass Spectrometry (GS-MS). Antifungal screening was done using agar well diffusion. CLSI M27-A3 was used to determine the Minimum Inhibitory (MIC) and Fungicidal Concentrations (MFC). Effects of HE-Pn on adhesion and germ tube of C. albicans (ATCC MYA-2876) were determined using XTT assay and germ tube formation assay, respectively. Transmission Electron Microscopy (TEM) was performed to visualize the post-exposure cellular changes. HE-Pn cytotoxicity was determined using human keratinocyte cell line (HaCaT). Chlorhexidine digluconate (2 mg/mL) was used as the positive control. Linolenic acid ethyl ester was the most abundant chemical component of HE-Pn. All strains tested were sensitive to HE-Pn. MIC were 0.03 - 8 mg/mL and MFC were 0.5 - 64 mg/mL for all test strains. C. albicans (ATCC MYA-2876) showed 50% of adhesion reduction with > 4 mg/mL of HE-Pn and germ-tube formation was inhibited with 0.25 and 2 mg/mL. TEM exhibited cytoplasmic granulation, intracellular vacuoles, detachment of cell wall and plasma membrane and chromatin condensation of Candida. No toxicity of HE-Pn was noted on HaCaT cells. HE-Pn shows an anti-Candida activity and can be used as an inhibitory agent against adhesion and germ tube formation of Candida albicans (ATCC MYA-2876) without causing any toxicity to human cells.

https://doi.org/10.1590/1678-4324-2022210539

Muscle pain induced by static contraction is modulated by transient receptor potential vanilloid 1 and ankyrin 1 receptors
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Jorge, Carolina Ocanha

; Melo-Aquino, Bruna de

; Santos, Diogo Francisco da Silva dos

; Oliveira, Maria Cláudia Gonçalves de

Brazilian Journal of Pharmaceutical Sciences

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2022, Volumen 58 elocation e20110

Resumen: En | Texto: En | PDF: En

Abstract Molecular mechanisms involved in the development of muscle pain induced by static contraction are not completely elucidated. This study aimed to evaluate the involvement of the transient receptor potential vanilloid 1 (TRPV1) and the transient receptor potential ankyrin 1 (TRPA1) receptors expressed in peripheral and central terminals of primary afferents projected to gastrocnemius muscle and spinal cord in muscle pain induced by static contraction. An electrical stimulator provided the contraction of rat gastrocnemius muscle and mechanical muscle hyperalgesia was quantified through the pressure analgesimeter Randall-Selitto. AMG9810 and HC030031 were used. When administered in ipsilateral, but not contralateral gastrocnemius muscle, drugs prevented mechanical muscle hyperalgesia induced by static contraction. Similar results were obtained by intrathecal administrations. We propose that, in an inflammatory muscle pain, peripheral and central TRPV1 and TRPA1 work together to sensitize nociceptive afferent fibers, and that TRPV1 and TRPA1 receptors are potential target to control inflammatory muscle pain.

https://doi.org/10.1590/s2175-97902022e20110

Ocean surface change detection from remote sensing image based on stochastic similarity measure
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Braga, Ian Henrique Teles

; Sacramento, Vinicius Pereira do

; Oliveira, Lígia Claudia Castro de

; Medeiros, Fátima Nelsizeuma Sombra de

; Rodrigues, Francisco Alixandre Ávila

RBRH

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2022, Volumen 27 elocation e39

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A detecção de mudanças com base em imagens de sensoriamento remoto tem atraído cada vez mais atenção de pesquisadores em todo o mundo. As imagens de radar de abertura sintética (SAR) tornaram-se recursos fundamentais para detectar mudanças na superfície terrestre. No entanto, devido à presença do ruído speckle e sua natureza estocástica, os dados SAR requerem metodologias que considerem essas peculiaridades. Este artigo apresenta uma medida de similaridade que considera a aleatoriedade presente nos dados SAR. Para recuperar o componente aleatório nos dados SAR, usamos distância estocástica. A medida de similaridade foi cuidadosamente elaborada em função da distância estocástica de forma que seu espaço de variação fosse o intervalo [0, 1], facilitando sua interpretação. Nossa proposta mostra resultados promissores em duas aplicações: avaliação de contraste, detecção de mudanças na superfície oceânica e mapa binário de mudanças. Vale ressaltar que as possíveis limitações de nossa proposta foram investigadas por meio de simulações guiadas por um experimento de Monte Carlo.

ABSTRACT Change detection based on remote sensing images, has attracted increasing attention from researchers throughout the world. The synthetic aperture radar (SAR) images have become key resources for detecting changes on the land surface. However, due to the presence of speckle noise and its stochastic nature, SAR data require methodologies that consider these peculiarities. This article presents a similarity measure that considers the randomness present in SAR data. To retrieve the random component in the SAR data, we used the stochastic distance. The similarity measure is carefully elaborated as a function of the stochastic distance such that its variation space is the interval [0, 1], facilitating its interpretation. Our proposal shows promising results in two applications: contrast evaluation, ocean surface change detection and binary change map. It is noteworthy that the possible limitations of our proposal are investigated through simulations guided by a Monte Carlo experiment.

https://doi.org/10.1590/2318-0331.272220220093

Recommendations by the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and the Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) on vaccination in general and specifically against SARS-CoV-2 for patients with demyelinating diseases of the central nervous system
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Becker, Jefferson

; Ferreira, Lis Campos

; Damasceno, Alfredo

; Bichuetti, Denis Bernardi

; Christo, Paulo Pereira

; Callegaro, Dagoberto

; Peixoto, Marco Aurélio Lana

; Sousa, Nise Alessandra De Carvalho

; Almeida, Sérgio Monteiro De

; Adoni, Tarso

; Santiago-Amaral, Juliana

; Junqueira, Thiago

; Pereira, Samira Luisa Apóstolos

; Gomes, Ana Beatriz Ayroza Galvão Ribeiro

; Pitombeira, Milena

; Paolilo, Renata Barbosa

; Grzesiuk, Anderson Kuntz

; Piccolo, Ana Claudia

; D´Almeida, José Arthur Costa

; Gomes Neto, Antonio Pereira

; Oliveira, Augusto Cesar Penalva De

; Oliveira, Bianca Santos De

; Tauil, Carlos Bernardo

; Vasconcelos, Claudia Ferreira

; Kaimen-Maciel, Damacio

; Varela, Daniel

; Diniz, Denise Sisterolli

; Oliveira, Enedina Maria Lobato De

; Malfetano, Fabiola Rachid

; Borges, Fernando Elias

; Figueira, Fernando Faria Andrade

; Gondim, Francisco De Assis Aquino

; Passos, Giordani Rodrigues Dos

; Silva, Guilherme Diogo

; Olival, Guilherme Sciascia Do

; Santos, Gutemberg Augusto Cruz Dos

; Ruocco, Heloisa Helena

; Sato, Henry Koiti

; Soares Neto, Herval Ribeiro

; Cortoni Calia, Leandro

; Gonçalves, Marcus Vinícius Magno

; Vecino, Maria Cecilia Aragón De

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise De Castro

; Boaventura, Mateus

; Parolin, Mônica Koncke Fiuza

; Melo, Renata Brant De Souza

; Lázaro, Robson

; Thomaz, Rodrigo Barbosa

; Kleinpaul, Rodrigo

; Dias, Ronaldo Maciel

; Gomes, Sidney

; Lucatto, Simone Abrante

; Alves-Leon, Soniza Vieira

; Fukuda, Thiago

; Ribeiro, Taysa Alexandrino Gonsalves Jubé

; Winckler, Thereza Cristina D’ávila

; Fragoso, Yara Dadalti

; Nascimento, Osvaldo José Moreira Do

; Ferreira, Maria Lucia Brito

; Mendes, Maria Fernanda

; Brum, Doralina Guimarães

; Glehn, Felipe Von

Arquivos de Neuro-Psiquiatria

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Nov 2021, Volumen 79 Nº 11 Paginas 1049 - 1061

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O DC de Neuroimunologia da ABN e o BCTRIMS trazem, nesse documento, as recomendações sobre vacinação da população com doenças desmielinizantes do sistema nervoso central (SNC) contra infecções em geral e contra o coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), causador da COVID-19. Destaca-se a gravidade do atual momento frente ao avanço da COVID-19 em nosso País, o que torna mais evidente e importante a criação de guia de referência para orientação aos médicos, pacientes e autoridades de saúde pública quanto à vacinação, meio efetivo e seguro no controle de determinadas doenças infecciosa. O DCNI/ABN e o BCTRIMS recomendam que os pacientes com doenças desmielinizantes do SNC (ex., EM e NMOSD) sejam constantemente monitorados, quanto a atualização do seu calendário vacinal, especialmente, no início ou antes da mudança do tratamento com uma droga modificadora de doença (DMD). É importante também salientar que as vacinas são seguras e os médicos devem estimular o seu uso em todos os pacientes. Evidentemente, deve ser dada especial atenção às vacinas com vírus vivos atenuados. Por fim, é importante que os médicos verifiquem qual DMD o paciente está em uso e quando foi feita a sua última dose, pois cada fármaco pode interagir de forma diferente com a indução da resposta imune.

ABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize the seriousness of the current situation in view of the spread of COVID-19 in our country. Therefore, reference guides on vaccination for clinicians, patients, and public health authorities are particularly important to prevent some infectious diseases. The DCNI/ABN and BCTRIMS recommend that patients with CNS demyelinating diseases (e.g., MS and NMOSD) be continually monitored for updates to their vaccination schedule, especially at the beginning or before a change in treatment with a disease modifying drug (DMD). It is also important to note that vaccines are safe, and physicians should encourage their use in all patients. Clearly, special care should be taken when live attenuated viruses are involved. Finally, it is important for physicians to verify which DMD the patient is receiving and when the last dose was taken, as each drug may affect the induction of immune response differently.

https://doi.org/10.1590/0004-282x-anp-2021-0162 1 descargas

10.

The impact of visceral fat and levels of vitamin D on coronary artery calcification
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Rodrigues, Isa Galvão

; Pinho, Claudia Porto Sabino

; Sobral Filho, Dário

; Leão, Ana Paula Dornelas

; Oliveira, Maria Cristina Monterio

; Barbosa, Gerssica Pina

; Siqueira, Aline Alves de

; Bandeira, Francisco

Revista da Associação Médica Brasileira

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Ene 2021, Volumen 67 Nº 1 Paginas 88 - 93

Resumen: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: To evaluated calcification of the coronary arteries and its association with visceral fat and 25-hydroxyvitamin D (25(OH)D) serum levels. METHODS: A cross sectional study involving 140 individuals without any previous diagnosis of cardiovascular disease. A biochemical analysis of vitamin D serum levels was carried out, as well as computed tomography to measure coronary artery calcium score and visceral adipose tissue. RESULTS: The mean age of the individuals was 55.9 (±12.4). Coronary artery calcium was observed in 40.7% of the population. Vitamin D presented median serum levels of 30.4 ng/ml (IQ24.5–39.1), with 14,1 and 33.7% of the individuals presenting deficiency and insufficiency, respectively. In the univariate analysis, the calcium score was more prevalent in aged patients (p<0.01), in hypertensive individuals (p<0.01), in diabetics (p=0.02), and in those with a higher concentration of VAT (p=0.02). In the adjusted analysis, it was found that the highest concentration of VAT (OR: 4.0; 95%CI 1.4–11.7), hypertension (OR: 4.8; 95%CI 1.5–15.3), and age (OR: 10.4; 95%CI 3.9–27.6) were predictors of subclinical atherosclerosis, regardless of body mass index, diabetes, and 25OHD. CONCLUSIONS: Excess visceral fat was associated with subclinical atherosclerosis, regardless of other risk factors for cardiovascular disease. Serum levels of 25OHD were not associated with CAD in its early stages.

https://doi.org/10.1590/1806-9282.67.01.20200388 309 descargas

11.

Spatial distribution of human visceral leishmaniasis cases in Cametá, Pará, Eastern Amazon, Brazil
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Miranda, Claudia do Socorro Carvalho

; Bonito, Jorge

; Oliveira, Rafael Aleixo Coelho de

; Guedes, Juan Andrade

; Santos, Conceição

; Oliveira, João Sérgio de Sousa

; Filgueiras, Tainara Garcia

; Oliveira, Francisco de Assis

; Filgueiras, Tainã Garcia

; Gonçalves, Nelson Veiga

Revista da Sociedade Brasileira de Medicina Tropical

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2021, Volumen 54 elocation e0220-2021

Resumen: En | Texto: En | PDF: En

Abstract INTRODUCTION: Human visceral leishmaniasis is considered a major public health problem in the municipality of Cametá, Pará, Brazil. METHODS: This ecological study was conducted using data obtained from official Brazilian agencies. Spatial analysis of the variables was performed using the kernel interpolation technique and the bivariate Global Moran’s Index. RESULTS: The spatial distribution of the disease was not homogeneous, and it was associated with socio-environmental risk factors and public policies. CONCLUSIONS: Different relationships were observed between the variables studied and disease occurrence.

https://doi.org/10.1590/0037-8682-0220-2021

12.

Cytochrome P450 enzymes inhibitor in the control of Digitaria insularis
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Carvalho, Gledson Soares de

; Leal, Jessica Ferreira Lourenço

; Souza, Amanda dos Santos

; Oliveira Junior, Francisco Freire de

; Langaro, Ana Claudia

; Pinho, Camila Ferreira de

Ciência e Agrotecnologia

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2021, Volumen 45 elocation e024520

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO As interações entre herbicidas quando misturados na calda de pulverização podem ser sinérgicas, aditivas ou antagônicas. Um exemplo de antagonismo está na associação entre os herbicidas 2,4-D e graminicidas. Há a suspeita de que o 2,4-D contribui para o aumento da atividade do Citocromo P450, podendo ser esta uma das causas do antagonismo. O objetivo deste estudo foi investigar o uso do inibidor das enzimas CYP450 in vivo, associado às misturas de herbicidas 2,4-D e inibidores da ACCase, no controle de Digitaria insularis. O experimento foi realizado em delineamento de blocos casualizados em esquema fatorial 6x2 com quatro repetições, sendo o fator A os herbicidas: controle 2,4-D (1005 g a.e. ha-1); cletodim (192 g a.i ha-1) e haloxifope (62,4 g a.i ha-1), 2,4-D+cletodim (1005 g a.e ha-1+192 g a.i ha-1), 2,4-D+haloxifope (1005 g a.e ha-1 +62.4 g a.i ha-1); e o fator B a presença ou não de malation (1000 g ha-1) aplicado duas horas antes dos herbicidas. Foi realizado um teste físico-químico para verificar a compatibilidade dos herbicidas no tanque. A aplicação do malation duas horas antes das misturas dos herbicidas 2,4-D+clethodim ou haloxyfop, não proporcionou controle satisfatório do capim-amargoso, sugerindo que as enzimas CYP450 inibidas pelo malation não estão envolvidas no efeito antagônico observado. A mistura de 2,4-D+haloxyfop demonstrou menos eficácia no controle do capim-amargoso quando comparada com 2,4-D+clethodim, porém ambas foram incompatíveis na mistura em tanque, o que pode estar associado à eficácia reduzida no manejo do capim-amargoso.

ABSTRACT Herbicide interactions can be synergic, additive, or antagonist when mixed in the spray tank. A good example is an association between 2,4-D and graminicides. One hypothesis is that 2,4-D contributes to increasing the Cytochrome P450 activity, which may be one of the causes of antagonism. This study aimed to investigate the use of CYP450 enzymes inhibitor associated with the herbicide mixtures 2,4-D and ACCase inhibitors in vivo on the control of Digitaria insularis. The experiment was performed using a randomized block design in a factorial scheme of 6x2 with four replications. Factor A consisted of untreated check, 2,4-D (1005 g a.e ha-1), clethodim (192 g a.i ha-1) and haloxyfop (62.4 g a.i ha-1), 2,4-D + clethodim (1005 g a.e ha-1+192 g a.i ha-1), and 2,4-D + haloxyfop (1005 g a.e ha-1 +62.4 g a.i ha-1). Factor B represented the presence or absence of malathion (1000 g ha-1) applied two hours before applying the herbicides. A physicochemical test was performed to verify the compatibility of the herbicides in the tank. Malathion application performed two hours before applying the herbicide mixtures (2,4-D and clethodim/haloxyfop) did not provide adequate control of sourgrass, suggesting that CYP450 enzymes inhibited by malathion are not involved in the antagonistic effect between 2,4-D and both graminicides in the management of sourgrass. The 2,4-D + haloxyfop in tank mix demonstrated less efficacy in controlling sourgrass than 2,4-D + clethodim, but both mixtures were incompatible in the tank mix, which may be associated with reduced efficacy in sourgrass management.

https://doi.org/10.1590/1413-7054202145024520 779 descargas

13.

Sweet Potato Flour as a Replacement for Ground Corn as an Energetic Concentrate
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Mibach, Marilisa

; Demarco, Claudia Faccio

; Barbosa, Antonio Amaral

; Oliveira, Lisandre de

; Corrêa, Marcio Nunes

; Pino, Francisco Augusto Burkert Del

; Rabassa, Viviane Rohrig

; Schmitt, Eduardo

; Kozloski, Gilberto Vilmar

; Brauner, Cassio Cassal

Ciência Rural

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2021, Volumen 51 Nº 10 elocation e20200838

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo desse estudo foi avaliar os efeitos dos diferentes níveis de substituição de milho moído por farinha de batata-doce na ingestão, digestibilidade, síntese de proteína microbiana e a retenção de Nitrogênio (N) em ovinos alimentados por dietas com base em silagem de milho. Foram utilizados oito ovinos machos castrados, mantidos em gaiolas metabólicas, divididos em quatro grupos no quadrado latino 4 x 4, totalizando quatro períodos de 15 dias cada. Os animais receberam proporções fixas de feno de aveia, silagem de milho e farelo de soja. O grupo controle (0%) recebeu apenas milho moído, enquanto os outros grupos receberam diferentes níveis de inclusão de farinha de batata doce (FBD) em substituição ao milho moído, nas proporções de 33%, 66% e 100%. Amostras de alimentos e sobras foram coletadas para avaliação do consumo e análise bromatológica. A urina foi coletada para avaliação da síntese proteica microbiana através dos derivados da purina (DP). As fezes foram coletadas para análise e estimativa da digestibilidade. Os grupos de 0% e 33% apresentaram menor consumo de fibra em detergente neutro (FDN) do que os grupos de 66% e 100%. Houve uma tendência (P = 0,07) de efeito dos tratamentos na ingestão de proteína bruta (PB) com efeito linear positivo significativo (P = 0,03). Houve uma tendência (P = 0,07) para os efeitos do tratamento na ingestão de N com um efeito linear positivo significativo (P = 0,03). Os demais parâmetros como excreção de N na urina (P = 0,91) e excreção de N nas fezes (P = 0,16) não foram afetados pela substituição do milho moído pela FBD. Além disso, não houve efeito na retenção de N (P = 0,43) e na eficiência do uso de N (P = 0,69). A adição de FBD a uma dieta em vez de milho não alterou os parâmetros das proteínas microbianas. A inclusão de farinha de batata-doce não causou alterações no metabolismo proteico dos animais, sugerindo que pode ser utilizada no lugar do milho.

ABSTRACT: This study evaluated the effects of different levels of substitution of ground corn by sweet potato flour on intake, digestibility, microbial protein synthesis and total Nitrogen (N) retention in sheep fed mixed diets based on corn silage. Eight castrated male sheep were used, kept in metabolic cages. The animals received fixed proportions of oat hay, corn silage and soybean meal. The control group (0%) received only ground corn, while the other groups received different levels of inclusion of sweet potato flour (SPF) to replace ground corn, in the proportions of 33%, 66%, and 100%. The 0% and 33% groups had lower neutral detergent fiber (NDF) intake than the 66% and 100% groups. There was a trend (P = 0.07) of effect of treatments on crude protein (CP) intake with a significant positive linear effect (P = 0.03). There was a trend (P = 0.07) for treatment effects in N intake with a significant positive linear effect (P = 0.03). The other parameters as urine N excretion (P = 0.91) and feces N excretion (P = 0.16) were not affected by the replacement of ground corn by SPF. Moreover, there was no effect on N retention (P = 0.43) and on efficiency of N use (P = 0.69). Adding SPF to a diet instead of corn did not alter the microbial protein parameters. The inclusion of sweet potato flour did not cause changes in the protein metabolism of animals, suggesting it can be used instead of corn.

https://doi.org/10.1590/0103-8478cr20200838 129 descargas

14.

Sourgrass and fleabane are controlled by haloxyfop-p-methyl and cloransulam-methyl interaction and interval of application
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Leal, Jéssica F. L.

; Borella, Junior

; Souza, Amanda dos S.

; Oliveira, Gabriella Francisco P. B. de

; Langaro, Ana Claudia

; Pinho, Camila F. de

Advances in Weed Science

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2021, Volumen 39 elocation e21237936

Resumen: En | Texto: En | PDF: En

Abstract Background Areas simultaneously infested with both glyphosate-resistant sourgrass (Digitaria insularis L.) and fleabane (Conyza spp.) are usual in Brazil. However, there are no effective management strategies to control both species concurrently. Objective The aim was to evaluate the interaction and interval of application of haloxyfop-P-methyl and cloransulam-methyl to effective control sourgrass (from 3- to 4-tillers to flowering stages) and fleabane (12- to 15-cm at the vegetative stage). Methods The experiment was conducted twice in a randomized complete blocks design with four biological replicates. The treatments were composed of sequential applications of haloxyfop-P-methyl (firstly applied) and cloransulam-methyl (secondly applied) and vice-versa. After the first application, the second one was applied in intervals of 3, 6 and 12 days. Haloxyfop-P-methyl and cloransulam-methyl were also applied in sequential (without interval), stand-alone applications of both herbicides and an untreated check. Results All treatments effectively controlled all fleabane plants. Haloxyfop-P-methyl applied ≥ 6 days before cloransulam-methyl controlled 100% of 3- to 4-tillers sourgrass and 60% of flowering sourgrass. Conclusions Therefore, haloxyfop-P-methyl may be applied ≥ 6 days before cloransulam-methyl in a sequential application structure to effectively control fleabane and sourgrass (3- to 4-tillers stage), when present concurrently.

https://doi.org/10.51694/advweedsci/2021;39:00010 840 descargas

15.

Role of FAK signaling in chagasic cardiac hypertrophy
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Tucci, Amanda R.

; Oliveira Jr, Francisco O. R. de

; Lechuga, Guilherme C.

; Oliveira, Gabriel M.

; Eleuterio, Ana Carolina

; Mesquita, Liliane B. de

; Farani, Priscila S.G.

; Britto, Constança

; Moreira, Otacílio C.

; Pereira, Mirian Claudia S.

Brazilian Journal of Infectious Diseases

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Oct 2020, Volumen 24 Nº 5 Paginas 386 - 397

Resumen: En | Texto: En | PDF: En

Abstract Cardiac hypertrophy and dysfunction are a significant complication of chronic Chagas disease, with heart failure, stroke, and sudden death related to disease progression. Thus, understanding the signaling pathways involved in the chagasic cardiac hypertrophy may provide potential targets for pharmacological therapy. Herein, we investigated the implication of focal adhesion kinase (FAK) signaling pathway in triggering hypertrophic phenotype during acute and chronic T. cruzi infection. C57BL/6 mice infected with T. cruzi (Brazil strain) were evaluated for electrocardiographic (ECG) changes, plasma levels of endothelin-1 (ET-1) and activation of signaling pathways involved in cardiac hypertrophy, including FAK and ERK1/2, as well as expression of hypertrophy marker and components of the extracellular matrix in the different stages of T. cruzi infection (60–210 dpi). Heart dysfunction, evidenced by prolonged PR interval and decrease in heart rates in ECG tracing, was associated with high plasma ET-1 level, extracellular matrix remodeling and FAK signaling activation. Upregulation of both FAK tyrosine 397 (FAK-Y397) and serine 910 (FAK-S910) residues phosphorylation as well as ERK1/2 activation, lead to an enhancement of atrial natriuretic peptide gene expression in chronic infection. Our findings highlight FAK-ERK1/2 signaling as a regulator of cardiac hypertrophy in Trypanosoma cruzi infection. Both mechanical stress, induced by cardiac extracellular matrix (ECM) augment and cardiac overload, and ET-1 stimuli orchestrated FAK signaling activation with subsequent activation of the fetal cardiac gene program in the chronic phase of infection, highlighting FAK as an attractive target for Chagas disease therapy.

https://doi.org/10.1016/j.bjid.2020.08.007 340 descargas

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