ABSTRACT OBJECTIVE This study aims to propose a comprehensive alternative to the Bland-Altman plot method, addressing its limitations and providing a statistical framework for evaluating the equivalences of measurement techniques. This involves introducing an innovative three-step approach for assessing accuracy, precision, and agreement between techniques, which enhances objectivity in equivalence assessment. Additionally, the development of an R package that is easy to use enables researchers to efficiently analyze and interpret technique equivalences. METHODS Inferential statistics support for equivalence between measurement techniques was proposed in three nested tests. These were based on structural regressions with the goal to assess the equivalence of structural means (accuracy), the equivalence of structural variances (precision), and concordance with the structural bisector line (agreement in measurements obtained from the same subject), using analytical methods and robust approach by bootstrapping. To promote better understanding, graphical outputs following Bland and Altman’s principles were also implemented. RESULTS The performance of this method was shown and confronted by five data sets from previously published articles that used Bland and Altman’s method. One case demonstrated strict equivalence, three cases showed partial equivalence, and one showed poor equivalence. The developed R package containing open codes and data are available for free and with installation instructions at Harvard Dataverse at https://doi.org/10.7910/DVN/AGJPZH. CONCLUSION Although easy to communicate, the widely cited and applied Bland and Altman plot method is often misinterpreted, since it lacks suitable inferential statistical support. Common alternatives, such as Pearson’s correlation or ordinal least-square linear regression, also fail to locate the weakness of each measurement technique. It may be possible to test whether two techniques have full equivalence by preserving graphical communication, in accordance with Bland and Altman’s principles, but also adding robust and suitable inferential statistics. Decomposing equivalence into three features (accuracy, precision, and agreement) helps to locate the sources of the problem when fixing a new technique.

Abstract Objective: To evaluate the preoperative muscle mass of patients with head and neck cancer (HNC) with computed tomography (CT), comparing the results obtained through analysis of cross-sectional areas at the level of the third lumbar vertebra (L3) with those obtained through analysis of cross-sectional areas at the levels of the third cervical and fourth thoracic vertebrae (C3 and T4, respectively). Materials and Methods: A total of 63 patients with HNC were evaluated preoperatively. Using CT, we assessed muscle mass at L3, as well as at C3 and T4. Results: Most (73.0%) of the patients had low muscle mass at L3, whereas 50.8% had a normal body mass index. The cross-sectional area at L3 correlated strongly with those at C3 and T4 (r = 0.831 and r = 0.763, respectively; p < 0.001 for both). In addition, the muscle mass index at L3 correlated strongly with those at C3 and T4 (r = 0.781 and r = 0.715, respectively; p < 0.001 for both). Conclusion: Low muscle mass appears to be highly prevalent in patients with HNC. Measurements at C3 and T4 could represent alternative means of assessing muscle mass in such patients.

Resumo Objetivo: Avaliar e comparar a massa muscular de pacientes com câncer de cabeça e pescoço (CCP) durante o período pré-operatório com tomografia computadorizada (TC), por meio da análise das áreas transversais no nível da terceira vértebra lombar (L3) em comparação com níveis cervical (C3) e torácico (T4). Materiais e Métodos: Sessenta e três pacientes com CCP foram avaliados no pré-operatório. A TC foi utilizada para avaliar a massa muscular de L3, assim como as secções transversais de C3 e T4. Resultados: A maioria dos pacientes (73,0%) tinha baixa massa muscular analisada pela TC de L3, mas índice de massa corpórea normal (50,8%). Também foi observada forte correlação entre as áreas e o índice de massa muscular (IMM) de L3 com C3 (área: r = 0,831, p < 0,001; IMM: r = 0,781, p < 0,001) e T4 (área: r = 0,763, p < 0,001; IMM: r = 0,715, p < 0,001). Conclusão: A baixa massa muscular é altamente prevalente em pacientes com CCP. As análises de TC em C3 e T4 podem representar opção para avaliar a massa muscular em pacientes com CCP.

Abstract The objective of this work was to establish possible lexical ambiguities related to the words chance, random and uncertainty by 61 students of the fifth year of Elementary School (9 to 11 years old) of a public school in Barueri, São Paulo, Brazil, seeking find out what probabilistic meanings do they indicate based on everyday knowledge and/or what they learned at school. This was exploratory research, with a qualitative and quantitative approach, in which multivariate textual analyzes were carried out, such as Similarity Analyzes and Descending Hierarchical Classification - CHD, using the IRaMuTeQ software (R Interface for Multidimensional Text and Questionnaire Analysis). The results indicate that children have formalized, even if intuitively, since the early years of basic education, probabilistic notions such as, for example, determining the meaning of the words chance, random and uncertainty, and there should be concern in working on these concepts. We conclude that, lexical ambiguities are presented in relation to the terms under study, starting from the intuitive meaning that is constituted as a basic element that the students presented for then, to build a connection with the probabilistic language, allowing them to start using a precise language and specialized.

Resumen El objetivo de este trabajo fue establecer posibles ambigüedades léxicas relacionadas con las palabras causalidad, aleatorio y incertidumbre por 61 alumnos del quinto año de la Enseñanza Primaria (9 a 11 años) de una escuela pública de Barueri, São Paulo, Brasil, buscando averiguar qué significados probabilísticos indican a partir de los conocimientos cotidianos y/o aprendidos en la escuela. Se trata de una investigación exploratoria, con enfoque cualitativo y cuantitativo, en la que se realizaron análisis textuales multivariados, como Análisis de Similitud y Clasificación Jerárquica Descendente - CHD, utilizando el software IRaMuTeQ (R Interface for Multidimensional Text and Questionnaire Analysis). Los resultados indicaran que los niños han formalizado, aunque sea intuitivamente, desde los primeros años de la educación básica, nociones probabilísticas como, por ejemplo, determinar el significado de las palabras casualidad, aleatoriedad e incertidumbre, y debe haber preocupación en trabajar estos conceptos. Concluimos que, se presentan ambigüedades léxicas en relación con los términos en estudio, partiendo del significado intuitivo que se constituye como un elemento básico que presentaron los estudiantes para, luego, construir una conexión con el lenguaje probabilístico, permitiéndoles comenzar a utilizar un lenguaje preciso y especializado.

ResumO O objetivo deste trabalho foi estabelecer possíveis ambiguidades lexicais relacionadas aos vocábulos aleatório, acaso e incerteza por 61 alunos do quinto ano do Ensino Fundamental (9 a 11 anos) de uma escola municipal de Barueri, São Paulo, Brasil, buscando descobrir quais significados probabilísticos esses indicam a partir do conhecimento do dia a dia e/ou do que aprenderam na escola. Esta pesquisa foi do tipo exploratório, de abordagem qualitativa e quantitativa, na qual foram realizadas análises textuais multivariadas como Análises de Similitude e Classificação Hierárquica Descendentes - CHD, por meio do software IRaMuTeQ (Interface R para Texto Multidimensional e Análise de Questionário). Os resultados indicaram que as crianças tem formalizado, mesmo que intuitivamente, desde os anos iniciais da educação básica, noções probabilísticas como, por exemplo, determinar o significado das palavras acaso, aleatório e incerteza, devendo haver a preocupação em trabalhar esses conceitos. Concluímos que, foram apresentadas ambiguidades léxicas em relação aos termos em estudo, partindo do significado intuitivo que se constitui como um elemento básico que os alunos apresentaram para então, construir uma conexão com a linguagem probabilística, permitindo a esses começar a usar uma linguagem precisa e especializada.

ABSTRACT Objective: Herein, we compared ambulatory blood pressure (ABP) between young adults with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase enzyme (21OHase) deficiency and a control group. Additionally, we analyzed correlations between the glucocorticoid dose and androgen levels and ABP parameters. Subjects and methods: This case-control study included 18 patients (6 males and 12 females) and 19 controls (8 males and 11 females) matched by age (18-31 years). ABP monitoring was used to estimate blood pressure (BP) over a 24-h period. Results: No difference was noted between patients and controls in terms of systolic BP (males, 115.5 ± 5.6 vs. 117.0 ± 9.3, P = 0.733; and females, 106.4 ± 7.9 vs. 108.4 ± 7.6, P = 0.556, respectively) and diastolic BP during 24 h (males, 62.8 ± 7.5 vs. 66.2 ± 5.6, P = 0.349; and females, 62.7 ± 4.9 vs. 62.3 ± 4.9, P = 0.818, respectively). Systolic and diastolic BP and pulse pressure during daytime and nocturnal periods were similar between patients and controls. Furthermore, no differences were detected in the percentage of load and impaired nocturnal dipping of systolic and diastolic BP between patients and controls during the 24-h period. Additionally, the glucocorticoid dose (varying between r = −0.24 to 0.13, P > 0.05) and androgens levels (varying between r = 0.01 to 0.14, P > 0.05) were not associated with ABP parameters. Conclusion: No signs of an elevated risk for hypertension were observed based on ABP monitoring in young adults with CAH attributed to 21OHase deficiency undergoing glucocorticoid replacement therapy.

Resumo Objetivo: Avaliar e comparar a massa muscular de pacientes com câncer de cabeça e pescoço (CCP) durante o período pré-operatório com tomografia computadorizada (TC), por meio da análise das áreas transversais no nível da terceira vértebra lombar (L3) em comparação com níveis cervical (C3) e torácico (T4). Materiais e Métodos: Sessenta e três pacientes com CCP foram avaliados no pré-operatório. A TC foi utilizada para avaliar a massa muscular de L3, assim como as secções transversais de C3 e T4. Resultados: A maioria dos pacientes (73,0%) tinha baixa massa muscular analisada pela TC de L3, mas índice de massa corpórea normal (50,8%). Também foi observada forte correlação entre as áreas e o índice de massa muscular (IMM) de L3 com C3 (área: r = 0,831, p < 0,001; IMM: r = 0,781, p < 0,001) e T4 (área: r = 0,763, p < 0,001; IMM: r = 0,715, p < 0,001). Conclusão: A baixa massa muscular é altamente prevalente em pacientes com CCP. As análises de TC em C3 e T4 podem representar opção para avaliar a massa muscular em pacientes com CCP.

Abstract Objective: To evaluate the preoperative muscle mass of patients with head and neck cancer (HNC) with computed tomography (CT), comparing the results obtained through analysis of cross-sectional areas at the level of the third lumbar vertebra (L3) with those obtained through analysis of cross-sectional areas at the levels of the third cervical and fourth thoracic vertebrae (C3 and T4, respectively). Materials and Methods: A total of 63 patients with HNC were evaluated preoperatively. Using CT, we assessed muscle mass at L3, as well as at C3 and T4. Results: Most (73.0%) of the patients had low muscle mass at L3, whereas 50.8% had a normal body mass index. The cross-sectional area at L3 correlated strongly with those at C3 and T4 (r = 0.831 and r = 0.763, respectively; p < 0.001 for both). In addition, the muscle mass index at L3 correlated strongly with those at C3 and T4 (r = 0.781 and r = 0.715, respectively; p < 0.001 for both). Conclusion: Low muscle mass appears to be highly prevalent in patients with HNC. Measurements at C3 and T4 could represent alternative means of assessing muscle mass in such patients.

Resumo Lesões Cervicais Não Cariosas (LCNC) são defeitos do tecido dentário, não relacionados à cárie, frequentemente observados na prática odontológica. O objetivo do estudo foi avaliar os efeitos da profundidade e espessura da dentina de LCNC na resposta à dor dentária por meio de testes de diagnóstico clínico. 86 dentes de 14 pacientes com LCNC foram avaliados por: profundidade da LCNC, testes clínicos (estímulo evaporativo, para detectar níveis de dor de hipersensibilidade dentinária, teste térmico frio para classificar a saúde pulpar, estímulos percussivos para avaliação do tecido perirradicular e tomografia computadorizada de feixe cônico (TCFC), para avaliação da espessura de dentina remanescente (EDR). Em termos de profundidade, a amostra foi dividida em dois grupos: G1- dentes com LCNCs ≤1,0mm e G2- dentes com LCNCs entre 1,1-2,0 mm. Os dados de dor dentária foram comparados pelo teste de Mann-Whitney e a EDR pelo teste t-Student e correlações pelo teste de Pearson (p <0,05). A profundidade da LCNC não influencia a resposta da dor dentária ao estímulo evaporativo (p = 0,129, teste térmico frio (p = 0,125), teste diagnóstico clínico de percussão vertical (p = 0,317) e horizontal (p = 0,119), porém o G1 apresentou maior EDR (p <0,001) e o teste de correlação mostrou que LCNC mais profunda apresenta menor EDR (p = 0,011 / r = -0,273). Conclusão: Dentes com LCNC de até 2mm de profundidade apresenta níveis semelhantes de dor para hipersensibilidade dentinária, pulpar e saúde perirradicular, independente da profundidade da LCNC. Entretanto, lesões com profundidade ≤1,0mmin apresentaram mais EDR nos achados tomográficos.

Abstract Non-carious Cervical Lesions (NCCL) are dental tissue defects, non-related to caries, frequently observed in the dental practice. The aim of this study was to evaluate the effects of NCCL on dentin depth and thickness and the response to dental pain by means of clinical diagnostic tests. 86 teeth from 14 patients with NCCL were assessed by: depth of NCCL, clinical tests (evaporative stimulus, to detect pain levels of dentin hypersensitivity, cold thermal test to classify pulp health, percussive stimuli to evaluate the periradicular tissues and cone beam computed tomography (tomography to evaluate remaining dentin thickness (RDT). In terms of depth, the sample was divided into two groups: G1- teeth with NCCLs ≤1.0mm and G2- teeth with NCCLs between 1.1-2.0 mm. Dental pain data were compared by Mann-Whitney test and RDT by Student’s t-test and correlations by the Pearson test (p<0.05). The depth of NCCL does not influence dental pain response to evaporative stimulus (p=0.129), cold thermal test (p = 0.125), vertical (p = 0.317) and horizontal (p = 0.119) percussion clinical diagnostic tests. However, G1 showed more RDT (p<0.001), and the correlation test showed that deeper NCCL presents smaller remaining dentin thickness (p=0.011/r=-0.273). In conclusion, tooth with NCCL up to 2mm-depth presents similar levels of pain for dentin hypersensitivity, pulp and periradicular tissue independent to NCCL depth, however, lesions with ≤1.0mm-depth showed greater RDT in tomographic findings.

RESUMO Selecionar novos genótipos de batata-doce, que sejam adaptados às condições edafoclimáticas e de cultivo das regiões produtoras, se faz necessário. Assim, objetivou-se avaliar o desempenho agronômico de genótipos experimentais de batata-doce de polpa branca em lavouras comerciais, buscando obter indicação do seu mérito como cultivares comerciais. Os experimentos foram conduzidos nos munícipios de Presidente Prudente-SP, Emilianópolis-SP, Tarabai-SP e Álvares Machado-SP. Foi adotado o delineamento experimental de blocos ao acaso, com cinco repetições, avaliando-se os genótipos UZBD-L1-04 e UZBD-L5-29, e utilizando as testemunhas Ligeirinha Paulista, Canadense e INIA Arapey. Foram avaliados a produtividade total de raízes tuberosas, número de raízes tuberosas comerciais, produção de raízes tuberosas comerciais, massa média de raízes tuberosas comerciais, porcentagem de massa seca de raízes tuberosas comerciais, sólidos solúveis, resistência a danos causados por pragas, comprimento, diâmetro e aparência das raízes. Concluiu-se que o genótipo UZBD-L1-04 obteve desempenho superior aos demais (média dos ambientes para produtividade total de raízes tuberosas de 31,76 t/ha), e possuindo potencial como cultivar para a região.

ABSTRACT Selecting new sweet potato genotypes that are adapted to the soil, climate, and cultivation conditions of the producing regions is necessary. Thus, the objective of this work was to evaluate the agronomic performance of experimental genotypes of white-fleshed sweet potato in commercial fields, seeking to evaluate their potential as commercial cultivars. The experiments were carried out in the municipalities of Presidente Prudente, Emilianópolis, Tarabai, and Álvares Machado in São Paulo state. The randomized complete block design with five repetitions was used in the experiments, where the genotypes UZBD-L1-04 and UZBD-L5-29 were evaluated along with the controls Ligeirinha Paulista, Canadense, and INIA Arapey. The assessed traits were tuberous root total yield, number of commercial tuberous roots, commercial tuberous root yield, average mass of commercial tuberous roots, percentage of commercial tuberous root dry mass, soluble solids, resistance to pest-caused damage, root length, diameter, and appearance. UZBD-L1-04 performed better than the other genotypes (the average of environments for tuberous root total yield was 31.76 t/ha), showing great potential as a commercial cultivar for the studied region.

RESUMO As pimentas do gênero Capsicum são ricas em antioxidantes sendo consideradas excelentes fontes de compostos que podem trazer benefícios à saúde humana, como vitamina C e compostos fenólicos que, por sua vez, são influenciados pelo estádio de maturação dos frutos. O objetivo deste trabalho foi determinar o ponto ideal de colheita em pimentas ‘Murupi’, direcionando seu mercado consumidor, com base nos atributos físicos, químicos e funcionais. Esses atributos foram avaliados durante a pós-colheita, onde os frutos foram embalados em filmes plásticos de polietileno de baixa densidade (PEBD) ou não, submetidos ao armazenamento refrigerado (25±1°C e 95±3% de U.R.) por 20 dias. Os tratamentos utilizados consistiram nos três diferentes pontos de maturação dos frutos no momento da colheita (coloração da epiderme: verde, parcialmente vermelha e totalmente vermelha). Foram realizadas as análises de vitamina C, fibras totais e solúveis, ORAC (Oxygen Radical Absorbance Capacity), DPPH (2,2-difenil-1-picrilhidrazil), açúcares totais e redutores, fenólicos totais, carotenoides, capsaicina e antocianinas. As pimentas colhidas em estádio imaturo (verde) apresentaram os maiores valores de vitamina C, fenólicos totais e teores de capsaicina, além das maiores médias em relação à atividade antioxidante dos frutos. Da mesma forma, o uso de embalagens de PEBD de 0.10 mm de espessura mostrou-se eficaz em retardar a maturação das pimentas em relação aos atributos sensoriais, em especial quanto ao teor de fibras totais, sendo também observado, neste caso, a melhor manutenção dos teores de vitamina C e capsaicina, de compostos fenólicos e a maior atividade antioxidante dos frutos.

ABSTRACT Peppers of the genus Capsicum are rich in antioxidants and considered to be an excellent source of compounds, which can bring benefits for human health, such as vitamin C and phenolic compounds. These compounds are influenced by the ripening stage of the fruits. Thus, the aim of this study was to determine the ideal harvest point for ‘Murupi’ pepper fruits, targeting the consumer market, based on physical, chemical, and functional attributes. These attributes were evaluated during postharvest, being the fruits packed in low density polyethylene plastic film (LDPE) and submitted to cold storage (25±1°C and 95±3% U.R.) for 20 days. The treatments consisted of three different fruit maturation stages at harvest time (fruit peel color: green, partially red and totally red). The authors analyzed the vitamin C, total and soluble fibers, ORAC (Oxygen Radical Absorbance Capacity), DPPH (2.2-diphenyl-1-picrylhydrazyl), total and reducing sugars, total phenolics, carotenoids, capsaicin and anthocyanins. The fruits harvested in immature stage (green) showed the highest values of vitamin C, total phenolics and, capsaicin contents, and also the highest averages of fruit antioxidant activity. The use of 0.10 mm-thick LDPE packages showed to be effective in delaying the maturation of pepper fruits in relation to sensory attributes, especially in terms of total fiber contents, being also observed, in this case, better maintenance of vitamin C and capsaicin contents, phenolic compounds and the highest antioxidant activity.

Resumo Objetivo Comparar o efeito da infiltração intraarticular do plasma rico em plaqueta com a do ácido hialurônico no tratamento de pacientes com osteoartrose primária de joelho. Métodos Realizou-se um ensaio clínico randomizado com 29 pacientes, sendo um grupo submetido à infiltração com ácido hialurônico (controle) e o outro com plasma rico em plaquetas. Os desfechos clínicos avaliados foram a escala visual analógica da dor; o questionário Western Ontario and McMaster Universities Arthritis Index (WOMAC), antes e depois da intervenção; e os efeitos adversos após as aplicações. Utilizou-se os testes do qui-quadrado e exato de Fisher para as variáveis categóricas, e o teste t de Student, análise de variância, e Wilcoxon para as variáveis contínuas, através do software R. Resultados A análise independente de cada grupo revelou uma diferença estatística nos meses iniciais, com melhora dos escores de dor e função; porém, com piora no 6° mês após o procedimento. Não houve diferença dos desfechos avaliados entre os grupos que foram submetidos à infiltração com ácido hialurônico ou com plasma rico em plaquetas. Não houve efeito adverso grave ou reação alérgica durante todo o seguimento. Conclusão A infiltração intraarticular com ácido hialurônico ou plasma rico em plaquetas nos joelhos dos pacientes com gonartrose primária apresentou melhora temporária dos sintomas de função e dor. Não houve diferença entre as duas intervenções.

Abstract Objective The present study aimed to compare the effects of intraarticular infiltration of platelet-rich plasma with those of hyaluronic acid infiltration in the treatment of patients with primary knee osteoarthritis. Methods A randomized clinical trial was conducted with 29 patients who received an intraarticular infiltration with hyaluronic acid (control group) or platelet-rich plasma. Clinical outcomes were assessed using the visual analog scale for pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire before and after the intervention. In addition, the posttreatment adverse effects were recorded. Categorical variables were analyzed using the chi-square and Fisher exact tests, whereas continuous variables were analyzed using the Student t test, analysis of variance, and the Wilcoxon test; all calculations were performed with the Stats package of the R software. Results An independent analysis of each group revealed a statistical difference within the first months, with improvement in the pain and function scores, but worsening on the 6th month after the procedure. There was no difference in the outcomes between the groups receiving hyaluronic acid or platelet-rich plasma. There was no serious adverse effect or allergic reaction during the entire follow-up period. Conclusion Intraarticular infiltration with hyaluronic acid or platelet-rich plasma in patients with primary knee gonarthrosis resulted in temporary improvement of functional symptoms and pain. There was no difference between interventions.

RESUMO A deficiência de vitamina A é frequente nos países em desenvolvimento. Neste contexto, a batata-doce pode ser uma aliada na reversão desse quadro, uma vez que apresenta baixo custo de aquisição e elevada disponibilidade de mercado. Além disso, alguns genótipos apresentam polpa de coloração laranja, rica em betacaroteno, que é o precursor da vitamina A. Assim, objetivou-se com a presente pesquisa selecionar genótipos de batata-doce de polpa laranja por meio do emprego de dois índices de seleção (Smith e Hazel e Mulamba & Mock). Para tanto, foram avaliadas sete famílias de meio irmãos com raízes de polpa laranja (141 genótipos experimentais e a cultivar comercial Beauregard), verificando-se os parâmetros produtivos, aparência externa das raízes, a intensidade de cor da polpa e suscetibilidade à Euscepes postfasciatus. Dessa forma, os genótipos UZBD-C-14, UZBD-U1-25, UZBD-F-15, UZBD-C-30, UZBD-K-32, UZBD-U1-10, UZBD-L2-14 e UZBD-L5-67 apresentaram-se mais promissores, demonstrando maior equilíbrio para os caracteres avaliados. Ademais, esses genótipos estão aptos a novos estudos, com propósito de confirmar o desempenho produtivo e de qualidade de raízes, além dos parâmetros bioquímicos que comprovem a herança do caráter que regula a biofortificação mediada pelos carotenos.

ABSTRACT Vitamin A deficiency is common in developing countries. Sweet potato can be an ally in reversing this situation since it has a low acquisition cost and high market availability. In addition, some genotypes have orange-flesh roots, rich in beta-carotene, which is the precursor of vitamin A. Thus, the objective of this research was to select orange-fleshed sweet potato genotypes using two selection indices (Smith and Hazel and Mulamba & Mock). For this purpose, seven half-sibling families with orange flesh roots (141 experimental genotypes and the commercial cultivar Beauregard) were evaluated, assessing yield-related traits, external appearance of roots, pulp color intensity, and susceptibility to Euscepes postfasciatus. The genotypes UZBD-C-14, UZBD-U1-25, UZBD-F-15, UZBD-C-30, UZBD-K-32, UZBD-U1-10, UZBD-L2-14, and UZBD-L5-67 were the most promising, showing greater balance for the evaluated characters. Furthermore, these genotypes are suitable for new studies to confirm their productive performance and root quality and evaluate the biochemical parameters that prove the inheritance of the character regulating biofortification mediated by carotenes.

Abstract Objective: Cognitive dysfunction may occur postoperatively. Fast and efficient assessment of Postoperative Cognitive Dysfunction (POCD) can minimize loss of quality of life, and therefore, a study comparing a digital game with standard neuropsychological tests to assess executive, mnemonic, and attention functions to evaluate POCD seems to be relevant both for research and clinical practice. Methods: A battery of standardized tests and a digital game (MentalPlus®) were administered to 60 patients at the Central Institute of Hospital das Clínicas in São Paulo (36 women and 24 men), with ages between 29 and 82 years, preand post-surgery performed under anesthesia. Correlation and linear regression model were used to compare the scores obtained from the standardized tests to the scores of the six executive and cognitive functions evaluated by the game (shortand long-term memory, selective and alternating attention, inhibitory control, and visual perception). Results: After correlation analysis, a statistically significant result was found mainly for the correlation between the scores from the phase of the digital game assessing the visuoperception function and the scores from the A and B cards of the Stroop Test (p < 0.001, r = 0.99 and r = 0.64, respectively), and the scores from TMTA (p = 0.0046, r = 0.51). We also found a moderate correlation between the phase of the game assessing short-memory function and VVLT (p < 0.001, r = 0.41). No statistically significant correlations were found for the other functions assessed. Conclusion: The digital game provided scores in agreement with standardized tests for evaluating visual perception and possibly short-term memory cognitive functions. Further studies are necessary to verify the correlation of other phases of the digital game with standardized tests assessing cognitive functions.

ABSTRACT A mathematical model was developed to describe the dynamics of the primary infection of dengue virus in infants who were born to a mother immune to some serotype of the dengue virus. The model is given by a system of nonlinear ordinary differential equations with time-dependent variables for the number of dengue virus antibodies of the infant transferred from their immune, uninfected, and infected monocytes and dengue virus. The mathematical analysis was carried out where the conditions for the existence of the disease-free equilibrium and the endemic equilibrium were established. The numerical simulations were performed considering different scenarios for a basic reproductive number, R 0, illustrating the global convergence of the numerical results for the equilibrium points. The results are in agreement with our derived global stability analysis. It can be concluded that dengue hemorrhagic fever in infants could occur in the peaks observed for the infected monocytes and dengue virus.

RESUMO A estimativa de valores Curva Número (CN) a partir de dados chuva-vazão é um tópico atrativo em hidrologia. No entanto, há carência de valores de CN para o material Pavimento de Concreto Intertravado (PCI), particularmente quando assentado sobre o solo exposto (não sobre uma estrutura de pavimentos permeáveis). Aqui, nós calculamos valores de CN para o PCI assentado sobre solo argiloso e usando dados medidos de chuva e capacidade de infiltração. Nós estimamos o escoamento superficial ( Q) usando dados de altura de chuva com duração de 24 horas ( P 24) junto com um modelo de infiltração, sob a hipótese do processo hortoniano de geração de Q. Para estimar o valor de CN para cada evento de chuva, nós adotamos a abordagem incremental do tipo chuva-vazão. Nós obtivemos valores de CN variando de 52 ( R M S E = 9,09 mm and R 2 = 0,03) a 63 ( R M S E = 1,45 mm and R 2 = 0,97). Resumidamente, os melhores valores de CN foram iguais a 52,2 e 60,1, considerando os dados P 24- Qordenados naturalmente e ranqueados, respectivamente. Nossos resultados indicam que é melhor usar um valor de taxa de abstração inicial ( λ) igual a 0,20 para o material PCI. As descobertas fornecem um melhor entendimento sobre o processo chuva-vazão no material PCI e ajudam a aprimorar projetos de sistemas de drenagem pluvial.

ABSTRACT Curve Number (CN) values estimating from rainfall-runoff data is an attractive topic in hydrology. However, CN values are lacking for Interlocking Concrete Pavement (ICP) material, mainly when seated over bare soil (not over a permeable pavement structure). Here, we compute CN values for the ICP seated over clayey soil using measured rainfall and infiltration capacity data. We estimated runoff ( Q) using 32 events of 24-hour rainfall depth ( P 24) and an infiltration model, assuming a hortonian runoff process. To estimate the CN for each P 24 event, we used the rainfall-runoff incremental approach. Overall, we obtained CN values ranging from 52 to 63. The best CN values to estimate Q were equal to 52.2 ( R M S E = 9.09 mm and R 2 = 0.03) and 60.1 ( R M S E = 1.45 mm and R 2 = 0.97), considering natural- and rank-ordered P 24- Q data, respectively. Our results indicate that it is more suitable to use the initial abstraction ratio ( λ) equal to 0.20 for the ICP material. The findings provide a better understanding of the rainfall-runoff process in ICP and help improve the design of stormwater drainage systems.

Aim To evaluate the psychological impact of COVID-19 on undergraduate and graduate students of the Dental School of Ribeirão Preto, University of São Paulo. Methods Three questionnaires were used: sociodemographic, WHO Abbreviated Quality of Life Inventory, and General Anxiety Disorder-7. Data were analyzed using Graph Pad Prism 7a (α = 5%). Mann-Whitney or Kruskal-Wallis and Dunn post-tests were used for statistical comparisons. The Spearman test was used as the correlation test. Results 257 students responded to the online form that assessed their quality of life and anxiety level. On a scale from 1 to 100, with 100 being the best quality of life, the average obtained was 64.71 (± 13.36). In addition, 87.6% of the students rated their quality of life as good or very good. 74.7% reported good or very good health. The anxiety analysis resulted in an average of 10.04 (± 4.5), indicating moderate anxiety levels. There was an inversely proportional correlation between age and degree of anxiety (p = 0.008, r = -0.1628) and self-perceived learning and student commitment (r = 0.69). Conclusion Despite the good quality of life and the students’ good self-perception of health, they showed a moderate degree of anxiety during the social distancing caused by COVID-19, also demonstrating a decrease in interest and commitment during distance education.

RESUMO Introdução: A musculatura paravertebral é essencial para a biomecânica e estabilidade da coluna e tem sido demonstrado seu envolvimento na fisiopatologia das doenças da coluna vertebral. A avaliação qualitativa da degeneração muscular é usualmente feita pela análise da taxa de infiltração de gordura proposta pelo Sistema de Classificação de Goutallier. Objetivo: O objetivo deste trabalho é analisar a concordância intra e interobservador da Classificação de Goutallier para avaliação da degeneração gordurosa do músculo multífido por meio de exames de ressonância magnética. Métodos: Fizeram parte do estudo 68 pacientes, todos com diagnóstico de hérnia discal sintomática e com indicação cirúrgica. As imagens de ressonância magnética colhidas no pré-operatório foram analisadas por dois ortopedistas e dois estudantes de medicina e foram reavaliadas duas semanas depois. Foi realizada análise de confiabilidade intra e interobservador por meio do teste Kappa de Fleiss e pelos critérios de Landis e Koch. Todas as análises foram realizadas com o auxílio do ambiente estatístico R (R Development Core Team, versão 3.3.1, 2016), e o nível de significância foi fixado em 5%. Resultados: As porcentagens de concordância intra e interobservadores foram, respectivamente, 86,76% e 61,03%. A concordância intraobservador foi quase perfeita e moderada interobservadores. Conclusões: O Sistema de Classificação de Goutallier demonstrou concordância moderada interobservador e intraobservador, sendo uma ferramenta relevante na avaliação da substituição gordurosa da musculatura paravertebral. Nível de evidência II; Estudo prospectivo para fins diagnósticos.

ABSTRACT Introduction: The paravertebral musculature is essential for the biomechanics and stability of the spine, and its involvement in the pathophysiology of spinal diseases has been demonstrated. Qualitative evaluation of muscle degeneration is usually performed by analyzing the fat infiltration rate proposed by the Goutallier classification system. Objective: The objective of this study is to analyze the intra- and interobserver agreement of the Goutallier Classification for the evaluation of fatty degeneration of the multifidus muscle, using magnetic resonance imaging exams. Methods: The study included 68 patients, all diagnosed with symptomatic disc hernia and indicated for surgery. Preoperative magnetic resonance images were used for the analyses. The images were initially evaluated by two orthopedists and two medical students, and then re-evaluated after two weeks. Intra- and inter-observer reliability analysis was performed using the Fleiss Kappa test and the Landis and Koch criteria. All the analyses were performed using the R statistical environment (R Development Core Team, version 3.3.1, 2016) and the significance level was set at 5%. Results: The percentages of intra- and inter-observer agreement were 86.76% and 61.03%, respectively. The intraobserver agreement was near perfect and the interobserver agreement was moderate. Conclusion: The Goutallier Classification System showed moderate interobserver and intraobserver agreement, being a relevant tool for the evaluation of paravertebral musculature fat replacement. Level of evidence II; Prospective study for diagnostic purposes.

RESUMEN Introducción: La musculatura paravertebral es fundamental para la biomecánica y la estabilidad de la columna y se ha demostrado su intervención en la fisiopatología de las enfermedades de la columna. La evaluación cualitativa de la degeneración muscular se suele realizar analizando la tasa de infiltración de grasa propuesta por el sistema de clasificación de Goutallier. Objetivo: El objetivo de este estudio es analizar la concordancia intra e interobservador de la Clasificación de Goutallier para evaluar la degeneración grasa del músculo multífido mediante resonancia magnética. Métodos: Formaron parte del estudio 68 pacientes, todos con diagnóstico de hernia discal sintomática y con indicación quirúrgica. Se utilizaron imágenes de resonancia magnética preoperatorias para el análisis. Las imágenes fueron evaluadas inicialmente por 02 ortopedistas y 02 estudiantes de medicina y, después de dos semanas, reevaluadas. El análisis de fiabilidad intra e interobservador se realizó mediante la prueba Kappa de Fleiss y los criterios de Landis y Koch. Todos los análisis se realizaron utilizando el entorno estadístico R (R Development Core Team, 2016), versión 3.3.1, y el nivel de significancia se estableció en 5%. Resultados: Los porcentajes de concordancia intra e interobservador fueron, respectivamente, 86,76% y 61,03%. La concordancia intraobservador fue casi perfecta y la concordancia interobservador fue moderada. Conclusión: el Sistema de Clasificación de Goutallier demostró una moderada concordancia interobservador e intraobservador, siendo una herramienta relevante en la evaluación del reemplazo graso de la musculatura paravertebral. Nivel de evidencia II; Estudio prospectivo con fines diagnósticos.