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The objective of this study was to evaluate the effect of pasteurization, lyophilization and spray-drying on the lipid profile of donated human milk (DHM) at different lactation stages. Nine frozen samples of colostrum, transitional and raw mature human milk (HM) were collected from the Human Milk Bank (HMB) of the Hospital Universitário de Maringá (HUM). Samples were thawed and pooled according to lactation stage. Thereafter, it was submitted to pasteurization, lyophilization and spray-drying processes and later the fatty acid (FA) composition and the lipid profile analyses were performed. Gas chromatograph (GC) with flame ionization detector (FID) and electrospray ionization (ESI) mass spectrometer (MS) were used, respectively. In the FA composition analysis, it was observed that the same classes of saturated FA (SFA), monounsaturated FA (MUFA) and polyunsaturated FA (PUFA) were preserved throughout the process and in all lactation stages. The lipid profiles were also preserved after processing. Therefore, the lyophilization and spray-drying processes are promising techniques to preserve the DHM in the HMB, once the components evaluated were preserved, and both techniques facilitate the transport and storage, as the techniques reduce the sample volume.

https://doi.org/10.21577/0103-5053.20220087

Divergence among mother trees of Handroanthus serratifolius (Vahl) S. O. Grose regarding seed quality traits
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Silva, Patrícia Cândido da Cruz

; Zanatto, Bruna

; Paula, Rinaldo Cesar de

Revista Ciência Agronômica

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2023, Volumen 54 elocation e20228428

Resumen: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Environmental influences and genetic variability can promote, within the same species, variations between plants with intrinsic traits to the seeds. This work aimed at investigating the divergence among Handroanthus serratifolius mother trees from traits related to the physiological quality of seeds. Seeds collected from 13 mother trees were submitted to tests germination, electrical conductivity (EC), cold, controlled deterioration, and accelerated aging. Five replications of 50 and 25 seeds each were used for the cold test and other tests, respectively. The average data per mother tree were submitted to cluster analysis by the methods of Ward, k-means, and Principal Component Analysis (PCA). The mother trees were grouped into 4 clusters by the Ward’s and K-means methods, and confirmed by the PCA, but with varying cluster compositions. Cluster 2 grouped the mother trees with lower seed quality as demonstrated by the lowest values for most of the evaluated traits, but the highest EC and the second-highest value for the germination uncertainty index. On the other hand, cluster 4 grouped the mother trees with better seed quality. Of the 22 evaluated traits, eight are probably suitable for discarding due to their little contribution to the original variability. The results of the different clustering methods indicate significant differences between the mother trees regarding the physiological quality of seeds, showing that these parameters may be used to guide breeding programs aiming to produce high-quality seeds and seedlings of H. serratifolius.

RESUMO As influências ambientais e a variabilidade genética podem promover variações entre plantas de uma mesma espécie em características intrínsecas às sementes. Objetivou-se avaliar a divergência entre árvores matrizes de Handroanthus serratifolius a partir de caracteres da qualidade fisiológica de sementes. Sementes colhidas de 13 árvores matrizes foram submetidas aos testes de germinação, condutividade elétrica (CE), de frio, deterioração controlada e envelhecimento acelerado. Foram usadas cinco repetições de 50 sementes para o teste de frio e de 25 sementes para os demais testes. Os dados médios por matriz foram submetidos às análises de agrupamento, pelos métodos de Ward, k-means e Análise de Componentes Principais (ACP). As árvores matrizes foram divididas em 4 grupos pelos métodos de Ward e K-means, e comprovados pela ACP, mas com variações na composição dos grupos entre os métodos. As matrizes do grupo 2 têm qualidade fisiológica inferior, com os menores valores para a maioria dos caracteres avaliados, porém o maior valor de CE e o segundo maior de índice de incerteza da germinação. Por outro lado, o grupo 4 é constituído por matrizes que apresentam sementes de melhor qualidade fisiológica. Oito dos 22 caracteres avaliados são passíveis de descarte, pois contribuem pouco para a variabilidade original dos dados. Os diferentes métodos de agrupamento apontam a existência de divergência entre as árvores matrizes em relação à qualidade fisiológica de sementes, sendo essas informações úteis e que poderão orientar programas de produção de sementes e mudas de H. serratifolius.

https://doi.org/10.5935/1806-6690.20230024

Levels of energy supplementation for heifers in Tifton 85 pasture on carcass characteristics, internal organs and meat quality
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SILVA, MARCELO A. DA

; ALVES FILHO, DARI C.

; MACHADO, DIEGO S.

; MARTINI, ANA PAULA M.

; CARDOSO, GILMAR S.

; BRONDANI, IVAN LUIZ

; COCCO, JOZIANE M.

; CATTELAM, PATRÍCIA M.M.

Anais da Academia Brasileira de Ciências

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2023, Volumen 95 Nº 4 elocation e20190309

Resumen: En | Texto: En | PDF: En

Abstract The objective of this study was to evaluate the effect of different levels of concentrate supplementation on carcass characteristics of heifers finished on Tifton 85 pasture. Thirty-two cross-breed heifers (Charolais and Nellore) on average aged 25.51 months and weighing 298 kg were used in a completely randomized experiment. The animals were distributed uniformly to receive four different levels of concentrates based on the body weight: 0.0; 0.4; 0.8 and 1.2%. Animals were slaughtered at 29 months of age. There was increasing linear effect of levels energy supplementation on: slaughter weight, hot and cold carcass weights,hot and cold dressing percentage, thigh thickness, carcass compactness, and L* and b* color values. It was observed quadratic effect of levels of energy supplementation on the percentage of fat in the carcass. Different levels of energy supplementation did not modify the accumulation of vital organs and visceral fat or the sensory attributes of the meat. Higher levels of energy supplementation promote increases in carcass traits of heifers when finished on Tifton 85 pasture.

https://doi.org/10.1590/0001-3765202320190309

Physical and chemical characteristics of meat from lambs fed sorghum silage with cashew bagasse
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BARRETO, HILTON F.M.

; ASSIS, ANA PAULA P. DE

; LIMA, RENATA N. DE

; SOARES, ELAINE C.A.

; SOUSA, ÊLIKA S. DE

; MOURA, ANDREZZA A.C.

; MELO, VITOR L.L.

; SOUZA, CICÍLIA M.S. DE

; E. NETO, JOÃO VIRGÍNIO

; LIMA, PATRÍCIA O.

Anais da Academia Brasileira de Ciências

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2022, Volumen 94 Nº 4 elocation e20200425

Resumen: En | Texto: En | PDF: En

Abstract This study was conducted to evaluate the effects of replacing forage sorghum for dehydrated cashew bagasse (DCB) in the proportions of 0; 8; 16 and 24%, based on the natural matter at the time of ensiling on the physicochemical parameters of meat from feedlot lambs. None of the physical parameters evaluated showed a significant difference between the substitution levels of sorghum forage for DCB. The final pH obtained in this study showed a value above the recommended for freshly slaughtered meat from animals 24 hours in refrigeration, being considered DFD meat (dark, firm and dry). Regarding the chemical parameters, it was observed that there were no significant differences between the levels of substitution of sorghum forage for DCB to variable moisture and ash was perceived negative linear effect for protein and quadratic effect on lipid levels meat. The replacement of forage sorghum up to 24% of dehydrated bagasse cashew the ensilage does not compromise the quality of the meat, however, the substitution of 8% is to be preferred because it provides meats with lower lipid content.

https://doi.org/10.1590/0001-3765202220200425

O Teste de Caminhada de 6 Minutos prevê a melhora física em longo prazo de sobreviventes à unidade de terapia intensiva: um estudo de coorte prospectiva
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Rosa, Regis Goulart

; Dietrich, Camila

; Valle, Enio Luiz Tschiedel do

; Souza, Denise

; Tagliari, Luciana

; Mattioni, Mariana

; Tonietto, Túlio Frederico

; Rosa, Rosa da

; Barbosa, Mirceli Goulart

; Lovatel, Gisele Agustini

; Lago, Pedro Dal

; Oliveira, Eubrando Silvestre

; Sganzerla, Daniel

; Andrade, Juliana M. S.

; Berto, Paula

; Cardoso, Paulo Ricardo

; Sanchez, Evelin Carneiro

; Falavigna, Maicon

; Maccari, Juçara G.

; Rech, Gabriela

; Robinson, Caroline

; Schneider, Daniel

; Leon, Patrícia de

; Biason, Lívia

; Teixeira, Cassiano

Revista Brasileira de Terapia Intensiva

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Sep 2021, Volumen 33 Nº 3 Paginas 374 - 383

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a capacidade do Teste de Caminhada de 6 Minutos para predizer a melhora do estado funcional físico em longo prazo de pacientes sobreviventes à unidade de terapia intensiva. Métodos: Foram avaliados, de forma prospectiva, entre fevereiro de 2017 e agosto de 2018, em um ambulatório pós-unidade de terapia intensiva, 32 sobreviventes à unidade de terapia intensiva. Foram inscritos consecutivamente os pacientes com permanência na unidade de terapia intensiva acima de 72 horas (para admissões emergenciais) ou acima de 120 horas (para admissões eletivas) que compareceram ao ambulatório pós-unidade de terapia intensiva 4 meses após receberem alta da unidade de terapia intensiva. A associação entre a distância percorrida no Teste de Caminhada de 6 Minutos realizado na avaliação inicial e a evolução do estado funcional físico foi avaliada durante 8 meses, com utilização do Índice de Barthel. Resultados: A distância média percorrida no Teste de Caminhada de 6 Minutos foi significantemente mais baixa nos sobreviventes à unidade de terapia intensiva do que na população geral (405m versus 557m; p < 0,001). A idade (β = -4,0; p < 0,001) e a fraqueza muscular (β = -99,7; p = 0,02) se associaram com a distância percorrida no Teste de Caminhada de 6 Minutos. A distância percorrida no Teste de Caminhada de 6 Minutos se associou com melhora do estado funcional físico no período de 8 meses de acompanhamento desses pacientes (razão de chance para cada 10m: 1,07; IC95% 1,01 - 1,16; p = 0,03). A área sob a curva Característica de Operação do Receptor para predição da melhora funcional física pelo Teste de Caminhada de 6 Minutos foi de 0,72 (IC95% 0,53 - 0,88). Conclusão: O Teste de Caminhada de 6 Minutos, realizado 4 meses após a alta da unidade de terapia intensiva, predisse com precisão moderada a melhora do estado funcional físico de sobreviventes à unidade de terapia intensiva.

ABSTRACT Objective: To evaluate the ability of the 6-Minute Walk Test to predict long-term physical functional status improvement among intensive care unit survivors. Methods: Thirty-two intensive care unit survivors were prospectively evaluated from February 2017 to August 2018 in a post-intensive care unit outpatient clinic in Brazil. Individuals with intensive care unit stays > 72 hours (emergency admissions) or > 120 hours (elective admissions) attending the post-intensive care unit clinic four months after intensive care unit discharge were consecutively enrolled. The association between the 6-Minute Walk Test distance at baseline and physical functional status was assessed over 8 months using the Barthel Index. Results: The mean 6-Minute Walk Test distance was significantly lower in intensive care unit survivors than in the general population (405m versus 557m; p < 0.001). Age (β = -4.0; p < 0.001) and muscle weakness (β = -99.7; p = 0.02) were associated with the 6-Minute Walk Test distance. A 6-Minute Walk Test distance was associated with improvement in physical functional status over the 8-month follow-up (odds ratio for each 10m of 1.07; 95%CI 1.01 - 1.16; p = 0.03). The area under the Receiver Operating Characteristic curve for the 6-Minute Walk Test prediction of physical functional status improvement was 0.72 (95%CI 0.53 - 0.88). Conclusion: The 6-Minute Walk Test performed 4 months after intensive care unit discharge predicted long-term physical functional status among intensive care unit survivors with moderate accuracy.

https://doi.org/10.5935/0103-507x.20210056 132 descargas

Choosing Wisely for Thyroid Conditions: Recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism
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Dora, Jose Miguel

; Biscolla, Rosa Paula Mello

; Caldas, Gustavo

; Cerutti, Janete

; Graf, Hans

; Hoff, Ana O.

; Mazeto, Glaucia M. F. S.

; Magalhães, Patrícia Kunzle Ribeiro

; Mesa Junior, Cleo Otaviano

; Scheffel, Rafael Selbach

; Teixeira, Patricia de Fatima dos Santos

; Vaisman, Fernanda

; Villagelin, Danilo

; Maia, Ana Luiza

Archives of Endocrinology and Metabolism

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Abr 2021, Volumen 65 Nº 2 Paginas 248 - 252

Resumen: En | Texto: En | PDF: En

ABSTRACT Objective: Choosing Wisely (CW) is an initiative that aims to advance the dialogue between physicians and patients about low-value health interventions. Given that thyroid conditions are frequent in clinical practice, we aimed to develop an evidence-based list of thyroid CW recommendations. Materials and methods: The Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) named a Task Force to conduct the initiative. The Task Force work was based on an electronic Delphi approach. The 10 recommendations that received the highest scores by the Task Force were submitted for voting by all SBEM associates. The 5 recommendations that received the highest scores by SBEM associates are presented herein. Results: The Task Force was composed of 14 thyroidologists from 10 tertiary-care, teaching-based Brazilian institutions. The brainstorming/ideation phase resulted in 69 recommendations. After the removal of duplicates and recommendations that did not adhere to the initiative's scope, 35 remained. Then the Task Force voted to attribute a grade (0 [lowest agreement] to 10 [highest agreement]) for each recommendation. The 10 recommendations that received the highest scores by the Task Force were submitted to all SBEM associates. A total of 683 associates voted electronically, attributing a grade (0 to 10) for each recommendation. The 5 recommendations that received the highest scores by the SBEM associates compose our final list. Conclusion: A set of recommendations to avoid unnecessary medical tests, treatments, or procedures for thyroid conditions are offered with a transparent methodology. This initiative aims to foster productive interactions between physicians and patients, stimulating shared decision-making.

https://doi.org/10.20945/2359-3997000000323 340 descargas

Quality of Handroanthus serratifolius (Vahl) S. O. Grose seeds evaluated by the electrical conductivity test
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Silva, Patrícia Cândido da Cruz

; Paula, Rinaldo Cesar de

; Valdovinos, Tamara Mariel

; Araújo, Márcio José de

Revista Ciência Agronômica

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2021, Volumen 52 Nº 3 elocation e20207365

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO - O teste de condutividade elétrica (CE) na avaliação do vigor das sementes relaciona-se diretamente com a integridade das membranas celulares e seu uso em espécies florestais é, ainda, restrito. Assim, objetivou-se analisar a eficiência desse teste na avaliação da qualidade fisiológica de sementes e da variabilidade entre árvores matrizes de Handroanthus serratifolius. Sementes de 15 matrizes foram avaliadas quanto à germinação (G%) e ao índice de velocidade de germinação (IVG). No teste de CE foram estudados dois volumes de água (75 e 100 mL) e cinco períodos de embebição (24, 48, 72, 96 e 120 h) das sementes, a 20 e 25 °C. Os dados do teste de germinação foram submetidos à análise de variância em delineamento de blocos casualizados (DBC), seguido de comparação de médias pelo teste de Scott-Knott, e os do teste de CE foram analisados em DBC em esquema de parcelas sub-subdivididas, com desdobramento da interação por análise de regressão polinomial. As matrizes foram divididas em quatro grupos quanto a G% e IVG. O teste de condutividade elétrica separou as matrizes em maior número de grupos, independentemente da temperatura, volume e período de embebição. O teste de CE conduzido a 20 °C, com 25 sementes embebidas em 75 mL de água desionizada por 48 h é adequado para a avaliação da qualidade fisiológica de sementes e da variabilidade entre matrizes de Handroanthus serratifolius (Vahl) S. O. Grose.

ABSTRACT - The electrical conductivity test (EC) used to evaluate seed vigor is directly related to the integrity of cell membranes, but its use in forest species is still restricted. Thus, the objective of this study is to analyze the efficiency of the EC test to evaluate physiological parameters regarding seed quality and the genetic variability among Handroanthus serratifolius mother trees. Seeds from 15 mother trees were evaluated for germination (G%) and germination speed index (GSI). In the EC test, the seeds were imbibed in two water volumes (75 and 100 mL) at 20 and 25 °C, and the electrical conductivity was measured after five imbibition periods (24, 48, 72, 96, and 120 h). The germination test data were submitted to a randomized block design (RBD) analysis of variance and means were compared by the Scott-Knott test. The EC test was conducted as an RBD in a split-split plot scheme, with interaction unfolding by polynomial regression analysis. The mother trees were divided into four groups regarding G% and SGI. The EC test separated the mother trees into a larger number of groups, regardless of temperature, volume, and imbibition period. In conclusion, the EC test consisting of imbibition 25 seeds in 75 mL of deionized water at 20 °C for 48 h is suitable for evaluating the physiological quality of seeds and the variability among mother trees of Handroanthus serratifolius (Vahl) S. O. Grose.

https://doi.org/10.5935/1806-6690.20210044 35 descargas

Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
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Fink, Thais T.

; Marques, Heloisa H.S.

; Gualano, Bruno

; Lindoso, Livia

; Bain, Vera

; Astley, Camilla

; Martins, Fernanda

; Matheus, Denise

; Matsuo, Olivia M.

; Suguita, Priscila

; Trindade, Vitor

; Paula, Camila S.Y.

; Farhat, Sylvia C.L.

; Palmeira, Patricia

; Leal, Gabriela N.

; Suzuki, Lisa

; Odone Filho, Vicente

; Carneiro-Sampaio, Magda

; Duarte, Alberto José S.

; Antonangelo, Leila

; Batisttella, Linamara R.

; Polanczyk, Guilherme V.

; Pereira, Rosa Maria R.

; Carvalho, Carlos Roberto R.

; Buchpiguel, Carlos A.

; Latronico, Ana Claudia

; Seelaender, Marilia

; Silva, Clovis Artur

; Pereira, Maria Fernanda B.

; Sallum, Adriana M. E.

; Brentani, Alexandra V. M.

; Neto, Álvaro José S.

; Ihara, Amanda

; Santos, Andrea R.

; Canton, Ana Pinheiro M.

; Watanabe, Andreia

; Santos, Angélica C. dos

; Pastorino, Antonio C.

; Franco, Bernadette D. G. M.

; Caruzo, Bruna

; Ceneviva, Carina

; Martins, Carolina C. M. F.

; Prado, Danilo

; Abellan, Deipara M.

; Benatti, Fabiana B.

; Smaria, Fabiana

; Gonçalves, Fernanda T.

; Penteado, Fernando D.

; Castro, Gabriela S. F. de

; Gonçalves, Guilherme S.

; Roschel, Hamilton

; Disi, Ilana R.

; Marques, Isabela G.

; Castro, Inar A.

; Buscatti, Izabel M.

; Faiad, Jaline Z.

; Fiamoncini, Jarlei

; Rodrigues, Joaquim C.

; Carneiro, Jorge D. A.

; Paz, Jose A.

; Ferreira, Juliana C.

; Ferreira, Juliana C. O.

; Silva, Katia R.

; Bastos, Karina L. M.

; Kozu, Katia

; Cristofani, Lilian M.

; Souza, Lucas V. B.

; Campos, Lucia M. A.

; Silva Filho, Luiz Vicente R. F.

; Sapienza, Marcelo T.

; Lima, Marcos S.

; Garanito, Marlene P.

; Santos, Márcia F. A.

; Dorna, Mayra B.

; Aikawa, Nadia E.

; Litvinov, Nadia

; Sakita, Neusa K.

; Gaiolla, Paula V. V.

; Pasqualucci, Paula

; Toma, Ricardo K.

; Correa-Silva, Simone

; Sieczkowska, Sofia M.

; Imamura, Marta

; Forsait, Silvana

; Santos, Vera A.

; Zheng, Yingying

Clinics

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2021, Volumen 76 elocation e3511

Resumen: En | Texto: En | PDF: En

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.

https://doi.org/10.6061/clinics/2021/e3511

Application of Nickel Ferrite Nanoparticles in Adsorption of Amoxicillin Antibiotic
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Caetano, Patricia M. A.

; Simões, Nathália M.

; Pinto, Paula S.

; Fernandez-Outon, Luis E.

; Albuquerque, Adriana S.

; Macedo, Waldemar A. A.

; Ardisson, José D.

Journal of the Brazilian Chemical Society

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Dic 2020, Volumen 31 Nº 12 Paginas 2452 - 2461

Resumen: En | Texto: En | PDF: En

According to the World Health Organization, amoxicillin (AMX) is the most widely consumed antibiotic in the world. Consequently, there is great interest in the development of new technologies that allow the removal of this type of contaminant, as exposure to antibiotic residues can cause a variety of adverse effects, such as toxicity and antimicrobial resistance. In this work, AMX adsorption from aqueous solution was investigated using nickel ferrite nanoparticles. The nanoadsorbents were prepared by the coprecipitation method, annealed at 300 to 700 °C, and characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Mössbauer spectroscopy (ME) and vibratory sample magnetometry (VSM). Nanoparticle size, pH and temperature were found to significantly affect the amount of adsorbed AMX. The pseudo-second order kinetic model described the adsorption process and the adsorption isotherm fitted to the Freundlich model. AMX adsorption capacity was 104-45 mg g−1 (miligram of AMX per gram of ferrite) for ferrite annealed at 300-700 °C, respectively. The nanoadsorbents employed showed higher AMX removal efficiency when compared to other iron oxides. Moreover, the good reuse results obtained showed their great potential for antibiotic removal by adsorption.

https://doi.org/10.21577/0103-5053.20200120 460 descargas

10.

An eco-friendly method for extraction and quantification of flavonoids in Dysphania ambrosioides
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Ferreira, Thaís M.S.

; Santos, Júlia A. dos

; Modesto, Leandra A.

; Souza, Ludimilla S.

; Santos, Maria Patrícia V. dos

; Bezerra, Debborah Gonçalves

; Paula, Joelma A. M. de

Revista Brasileira de Farmacognosia

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Abr 2019, Volumen 29 Nº 2 Paginas 266 - 270

Resumen: En | Texto: En | PDF: En

ABSTRACT Dysphania ambrosioides (L.) Mosyakin and Clemants (Syn: Chenopodium ambrosioides L.), Amaranthaceae, is a plant with antibacterial, antifungal, antioxidant, antiparasitic and antitumor properties that is commonly used in Brazilian folk medicine. In this work we performed the optimization of ultrasound-assisted extraction of flavonoids in the aerial parts of D. ambrosioides. The flavonoid concentrations, as rutin equivalents, were quantified with the aid of a validated spectrophotometric method. The Box–Behnken (33) design with response surface methodology, for the independent variables, extraction time, temperature, and ethanol content, were used for the optimization of ultrasound-assisted extraction. The analytical method was selective, linear, without matrix interference, accurate, precise and robust. The best conditions for the ultrasound-assisted extraction of flavonoids were: time of 60 min, temperature of 57 °C and ethanol content of 57% (w/w). The methods of extracting and quantifying flavonoids developed in the present study have provided be eco-friendly, simple, and useful to determine the flavonoid content, expressed as rutin equivalents, in the aerial parts of D. ambrosioides.

https://doi.org/10.1016/j.bjp.2019.01.004 745 descargas

11.

Thrombomodulin and interleukin 6 as potential biomarkers of endothelial dysfunction and inflammation after renal transplant
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Mota, Ana Paula L.

; Martins, Suellen R.

; Alves, Lorraine V.

; Cardoso, Carolina N.

; Alpoim, Patrícia N.

; Silva, Ieda de Fátima O.

; Mercês-de-Lucas-Júnior, Fernando das

; Lima, Cristiano X.

; Gomes, Karina B.

; Dusse, Luci Maria S.

Jornal Brasileiro de Patologia e Medicina Laboratorial

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Dic 2018, Volumen 54 Nº 6 Paginas 379 - 386

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: A disfunção endotelial pode contribuir para estados de hipercoagulabilidade e inflamação presentes no transplante renal e na doença renal crônica (DRC) e suas causas, podendo ser avaliada por marcadores como trombomodulina (TM), fator de von Willebrand (FvW) e interleucina 6 (IL-6). Objetivos: Avaliar TM, FvW e IL-6 em receptores do transplante renal (RTR) e associar seus níveis com a causa primária de DRC pré-transplante e função do enxerto. Métodos: Foram alocados 160 RTR em grupos de acordo com a causa primária da DRC (G1: glomerulopatias; G2: nefroesclerose hipertensiva; G3: nefropatia diabética; e G4: outras causas/etiologia desconhecida), os níveis plasmáticos de creatinina (C1 < 1.4 e C2 ≥ 1.4 mg/dl) e o ritmo de filtração glomerular estimado (eRFG) (R1< 60 e R2 ≥ 60 ml/min/1.73 m2). A TM e o FvW foram determinados pelo ensaio de imunoabsorção enzimática (ELISA) e a IL-6, por citometria de fluxo. Os resultados foram apresentados como mediana, mínimo e máximo; p < 0,05 foi considerado significativo. Resultados: Níveis de TM foram significativamente maiores no grupo G1 em comparação com os demais (G1: 8,38; G2: 5,51; G3: 5,88; G4: 6,33 ng/ml, p < 0,0001), e no grupo R1 comparado com o R2 (R1: 6,65; R2: 6,19 ng/ml, p = 0,02). A concentração de IL-6, avaliada pela intensidade média de fluorescência, foi maior no grupo C2 quando comparada com o C1 (C1: 7,9; C2: 13,35, p = 0,03). Não houve diferença entre os grupos para o FvW. TM correlacionou-se positivamente com IL-6 e creatinina e negativamente com eRFG. A IL-6 foi positivamente correlacionada com o FvW. Conclusão: TM e IL-6 podem ser apontadas como potenciais marcadores para avaliar a função do enxerto renal. A TM relacionou-se mais com a causa primária da DRC, se comparada com FvW e IL-6.

ABSTRACT Introduction: Endothelial dysfunction may contribute to hypercoagulable and inflammation states presents in renal transplant, chronic kidney disease (CKD) and its causes. These disorders can be evaluated by markers, such as thrombomodulin (TM), von Willebrand factor (vWF) and interleukin 6 (IL-6). Objectives: The aim of this study was to assess TM, vWF and IL-6 in renal transplant recipients (RTR) and associate their plasma levels with primary cause of end-stage renal disease (ESRD) and allograft function. Methods: 160 RTR were grouped according to the primary cause of CKD (G1: glomerulopathy; G2: hypertensive nephrosclerosis; G3: diabetic nephropathy; and G4: other causes/unknown etiology); creatinine plasma levels (C1 < 1.4 and C2 ≥ 1.4 mg/dl); and the estimated glomerular filtration rate (eGFR) (R1< 60 and R2 ≥ 60 ml/min/1.73 m2). TM and vWF were determined by the enzyme-linked immunosorbent assay (ELISA) and IL-6 by flow cytometry. The results were presented as median, minimum and maximum; p-value < 0.05 was considered statistically significant. Results: TM levels were significantly higher in the G1 group compared to the others (G1: 8.38; G2: 5.51; G3: 5.88; G4: 6.33 ng/ml, p < 0.0001), and in the R1 group compared to R2 (R1: 6.65; R2: 6.19 ng/ml, p = 0.02). The concentration of IL-6, measured by the mean fluorescence intensity, was higher in C2 group when compared to C1 (C1: 7.9; C2: 13.35, p = 0.03). There was no difference in vWF levels among groups. TM correlated positively with IL-6 and creatinine, and negatively with eGFR. IL-6 also correlated positively with vWF. Conclusion: TM and IL-6 can be identified as potential markers for evaluating renal graft function. TM was more related to the primary cause of CKD compared to vWF and IL-6.

https://doi.org/10.5935/1676-2444.20180059 722 descargas

12.

Actividad antiplasmodial in vitro de metabolitos secundarios de Solanum nudum provenientes de dos regiones de Colombia
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López-Barrios, Ena Patricia

; Pabón-Vidal, Adriana Lucía

; Blair-Trujillo, Silvia

; Morales-Morales, Paula Andrea

; Peláez-Jaramillo, Carlos Alberto

; Araque-Marín, Pedronel

Revista EIA

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Dic 2018, Volumen 15 Nº 30 Paginas 25 - 39

Resumen: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Solanum nudum es una planta nativa de Colombia, reconocida y usada para el tratamiento de la fiebre asociada a la malaria, específicamente en el área del pacífico del departamento de Nariño. En la presente investigación se realizó un estudio fitoquímico comparativo de la producción de los compuestos esteroidales de S. nudum provenientes de dos regiones de Colombia y su respectiva actividad antiplasmodial. La colección de las hojas de S. nudum se realizó en los municipios de Cocorná (Antioquia) y Tumaco (Nariño) en los meses de noviembre 2010 y junio 2011. La extracción de los metabolitos esteroidales presentes en las hojas colectadas de S. nudum se efectuó con solventes de baja, media y alta polaridad. El contenido de los metabolitos esteroidales se determinó por cromatografía líquida de alta resolución en fase reversa. La actividad antiplasmodial de los extractos fue evaluada en la cepa 3D7 de Plasmodium falciparum y su posible citoxicidad en la línea celular HepG-2. El contenido de compuestos esteroidales y la actividad antiplasmodial fue superior para los extractos de las regiones y los meses donde la precipitación promedio del lugar fue alterada debido al fenómeno de La Niña. Los extractos con mayor efecto antiplasmodial y citotóxico citotoxicidad fueron los obtenidos en el municipio de Tumaco.

Abstract Solanum nudum is a plant native to Colombia, is recognized and is used for the treatment of fever associated with malaria, specifically in the Pacífico area of Nariño department. In this research a comparative study of phytochemical production of steroidal compounds of S. nudum from two regions of Colombia and their respective antiplasmodial activity was carried out. The collection of the leaves of S. nudum was conducted in the municipalities of Cocorná (Antioquia) and Tumaco (Nariño) in the months of November 2010 and June 2011. The extraction of steroid metabolites present in the leaves were collected from S. nudum was performed with solvents low, medium and high polarity. The content of steroidal metabolites was determined by high resolution liquid chromatography in reverse phase. The antiplasmodial activity of the extracts was evaluated in 3D7 strain of Plasmodium falciparum and its potential cytotoxicity on the cell line HepG-2. The content of steroidal compounds and antiplasmodial activity was higher on extracts from regions and months where the mean precipitation was influenced due to La Niña phenomenon. The extracts more antiplasmodial effect and cytotoxicity were obtained from Tumaco municipality.

Resumo Solanum nudum é uma planta nativa da Colômbia, é reconhecido e é usado para o tratamento da febre associada à malária, especificamente na área pacífica do departamento de Nariño. Nesta pesquisa um estudo comparativo da produção fitoquímico de compostos esteróides de S. nudum de duas regiões da Colômbia e sua respectiva actividade antiplasmódica foi realizado. A coleta das folhas de S. nudum foi realizado nos municípios de Cocorná (Antioquia) e Tumaco (Nariño), nos meses de novembro de 2010 e junho de 2011. A extração de metabólitos esteróides presentes nas folhas foram coletadas de S. nudum foi realizada com solventes de baixa, média e alta polaridade. O teor de metabolitos esteróides foi determinada por cromatografia líquida de alta resolução em fase reversa. A actividade antiplasmódica dos extractos foi avaliada em 3D7 estirpe de Plasmodium falciparum e a sua citotoxicidade potencial na linha de células HepG-2. O teor de compostos esteróides e atividade antiplasmódica foi maior para os extratos regiões e meses em que a precipitação média do site foi alterada devido ao fenômeno do La Niña. Os extratos mais efeito antiplasmódica e citotoxicidade foram obtidos no município de Tumaco.

https://doi.org/10.24050/reia.v15i30.1033 207 descargas

13.

Aspartate aminotransferase to platelet ratio index (APRI) for differentiation of primary and secondary infection by dengue virus
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Martins, Suellen R.

; Pinheiro, Melina B.

; Dusse, Luci Maria S.

; Mota, Ana Paula L.

; Alpoim, Patrícia N.

Jornal Brasileiro de Patologia e Medicina Laboratorial

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Oct 2018, Volumen 54 Nº 5 Paginas 273 - 278

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO INTRODUÇÃO: A infecção pelo vírus da dengue (DENV) é considerada um grande problema de saúde pública nos países tropicais. A indisponibilidade de testes sorológicos em centros de saúde pública pode afetar negativamente o prognóstico do paciente. OBJETIVO: Este estudo teve como objetivo avaliar a precisão do volume médio de plaquetas (MPV) e o índice da relação de aspartato aminotransferase (AST) sobre plaquetas (APRI) como marcadores laboratoriais de infecção por DENV, que poderiam ser utilizados para diferenciar infecções primárias e secundárias. MÉTODOS: Foram avaliados os resultados laboratoriais de 503 pacientes com teste rápido positivo para infecção por DENV. RESULTADOS: Foram observadas trombocitopenia grave e disfunção hepática em pacientes com infecção secundária heterogênea por DENV. Nossos dados sugerem que o APRI foi capaz de distinguir os pacientes com infecção primária e secundária (p = 0, 006), com relevante sensibilidade (75%) e especificidade (76%) e corte de 1, 06. Um total de 80 de 105 (76%) pacientes com infecção primária por DENV tinha APRI ≤ 1, 06; e 12 (75%) com infecção secundária por DENV, APRI > 1, 06. Por outro lado, o MPV não mostrou significância na diferenciação de tipos de infecção, apresentando baixo valor da área sob a curva de característica de operação do receptor (ROC) (0, 61). CONCLUSÃO: APRI parece ser uma ferramenta poderosa para identificação precoce de casos de infecção secundária de DENV em centros de saúde.

ABSTRACT INTRODUCTION: Dengue virus (DENV) infection has been considered a major public health problem in tropical countries. The unavailability of serologic testing in public health centers might adversely impact patients' outcome. OBJECTIVE: This study aimed to evaluate the accuracy of mean platelet volume (MPV) and aspartate aminotransferase (AST) to platelet ratio index (APRI) as laboratory markers of DENV infection that could be used to differentiate primary and secondary infections. METHODS: We assessed laboratory results from 503 patients with positive rapid test for DENV infection. RESULTS: Severe thrombocytopenia and increased liver involvement were observed in patients with DENV heterotypic secondary infection. Our data suggest that APRI was able to distinguish patients with primary and secondary infection (p = 0.006) with a relevant sensitivity (75%), specificity (76%) and a cut-off of 1.06. A total of 80 out of 105 (76%) patients with primary DENV infection had APRI ≤ 1.06, and 12 (75%) with secondary DENV infection had APRI > 1.06. On the other hand, MPV did not show significance in the differentiation of types of infection, coming up with poor area under the receiver operating characteristic (ROC) curve (0.61). CONCLUSION: APRI seems to be a powerful tool for early identification of DENV secondary infection cases in health centers.

https://doi.org/10.5935/1676-2444.20180047 1025 descargas

14.

Anesthetic complications in diabetic dogs subjected to phacoemulsification
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Pacheco, Paula F.

; Galeazzi, Viviane S.

; Patrício, Geni C.F.

; Flôr, Patrícia B.

; Safatle, Angélica V.

; Cortopassi, Silvia R.G.

Pesquisa Veterinária Brasileira

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Jul 2018, Volumen 38 Nº 7 Paginas 1423 - 1430

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo do presente estudo foi comparar a incidência de complicações anestésicas em cães diabéticos e não diabéticos submetidos a cirurgia de facoemulsificação. Foram utilizados 30 cães, machos ou fêmeas de diversas raças. Os cães foram distribuídos em dois grupos: diabético (GD) (n=15) e controle (GC) (n=15). Os animais foram pré-tratados com acepromazina (0,03mg/kg) e meperidina (4mg/kg), pela via intramuscular. Após 20 minutos, a indução foi realizada com propofol (2 a 5mg/kg) e a manutenção da anestesia com isofluorano. Os animais foram monitorados e as variáveis de frequência cardíaca, frequência respiratória, saturação oxihemoglobina periférica, concentração dióxido de carbono no final da expiração, fração inspirada e expirada de isofluorano e pressão arterial invasiva, foram registradas em intervalos de 10 minutos durante o procedimento cirúrgico. A hemogasometria arterial foi realizada após a indução (T0) e ao final do procedimento cirúrgico (T40). A idade dos animais do grupo diabético (10±2 anos) foi superior em relação aos animais do grupo controle (6±2 anos) (p<0,0001). A concentração expirada de isofluorano após a indução foi 30% superior nos animais do grupo controle (GC 1,3±0,3%, GD 1,0±0,2%) (p<0,01). A complicação anestésica mais comum foi a hipotensão arterial, 80% dos animais diabéticos (n=12) apresentaram pressão arterial média inferior a 60mmHg (54±9.6 mmHg) após indução anestésica; 83% dos cães hipotensos (n=10) necessitaram de fármacos vasoativos para tratamento da hipotensão. Com relação às alterações hemodinâmicas, os pacientes diabéticos submetidos à anestesia geral foram mais propensos à hipotensão arterial que pode ser decorrente da resposta dos animais mais velhos aos fármacos empregados; entretanto essa alteração merece maior investigação.

ABSTRACT: The aim of this paper was to compare the incidence of anesthetic complications in diabetic and nondiabetic dogs subjected to phacoemulsification. In total, 30 male and female dogs of different breeds were used. The dogs were distributed into two groups: diabetic (DG) (n=15) and control (CG) (n=15). The animals were premedicated with acepromazine (0.03mg/kg) and meperidine (4mg/kg), intramuscularly. After 20 minutes, anesthesia was induced with propofol (2 to 5mg/kg) and maintained with isoflurane. The animals were monitored and the heart rate, respiratory rate, peripheral oxyhemoglobin saturation, end tidal carbon dioxide tension, inspired and expired isoflurane fraction, and invasive arterial pressure were recorded at 10 minute intervals during the surgical procedure. Arterial hemogasometry was performed after anesthetic induction (T0) and at the end of the surgical procedure. Diabetic patients (DG 10±2 years) were older than non-diabetic group (CG 6±2 years). The expired isoflurane fraction after induction was 30% higher in the control group (CG 1.3±0.3%, DG 1.0±0.2%) (p<0.01). The most common anesthetic complication was hypotension. In total, 80% of the diabetic animals (n=12) exhibited mean arterial pressure (MAP) lower than 60mmHg (54±9.6mmHg) after anesthetic induction, and 83% of the hypotensive dogs (n=10) required vasoactive drugs to treat hypotension. Regarding hemodynamic changes, diabetic patients subjected to general anesthesia were more likely to exhibit hypotension which may be due to the response of older animals to the drugs used; however, this change deserves further investigation.

https://doi.org/10.1590/1678-5150-pvb-5222 2117 descargas

15.

Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol
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SILVA, FERNANDO C.

; RODRIGUES, VANESSA G.

; DUARTE, LUCIENIR P.

; LULA, IVANA S.

; SINISTERRA, RUBEN D.

; VIEIRA-FILHO, SIDNEY A.

; RODRIGUES, RODRIGO A.L.

; KROON, ERNA G.

; OLIVEIRA, PATRÍCIA L.

; FARIAS, LUIZ M.

; MAGALHÃES, PAULA P.

; SILVA, GRÁCIA D.F.

Anais da Academia Brasileira de Ciências

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Sep 2017, Volumen 89 Nº 3 Paginas 1555 - 1564

Resumen: En | Texto: En | PDF: En

ABSTRACT Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antibacterial activity test with extracts of branches and heartwood and bark of roots from Maytenus gonoclada were conducted. Moreover, due the frequency of isolation of lupeol from Maytenus genus the antiviral activity against Dengue virus and cytotoxicity of lupeol and its complex with β-cyclodextrins were also tested. The results indicated the bioactivity of ethyl acetate extract from branches and ethanol extract from heartwood of roots of M. gonoclada against diarrheagenic bacteria. The lupeol showed potent activity against Dengue virus and low cytotoxicity in LLC-MK2 cells, but its complex with β-cyclodextrin was inactive. Considering the importance of novel and selective antiviral drug candidates the results seem to be promising.

https://doi.org/10.1590/0001-3765201720160046 1459 descargas

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