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ABSTRACT Background: The wood heat treatment results in the partial degradation of its chemical constituents, mainly cellulose and hemicellulose, reducing the hygroscopicity of the material. This process improves the dimensional stability and resistance to biodeterioration and worsens the mechanical resistance. This work aimed to evaluate the effect of heat treatment on the physical, anatomical, chemical, and mechanical properties of Fraxinus excelsior wood. In untreated and heat-treated wood, the pH, buffering capacity, basic density, equilibrium moisture content, shrinkage, wood anatomy, thermogravimetric behavior, and chemistry by conventional and FTIR methods were determined. Results: Heat treated wood had lower pH (5.50), equilibrium moisture content (6.26%), shrinkage (7,29%), holocellulose contents (55,96%) and higher buffering capacity (0,479 mmol/L), extractives (8,25%), and lignin contents (35,78%). Heat treatment reduced the pH and increased the buffering capacity of the wood, reduced the holocellulose content, and increased the lignin content, leaving the wood less hygroscopic and reducing its volumetric and linear variation. The process did not change the basic density and fiber length, but it reduced their width, lumen diameter, and wall thickness. The FTIR analysis confirmed the degradation of holocellulose and division of aliphatic side chains in lignin. The maximum dredging range of untreated and heat-treated wood occurred at 350 ºC, and the heat-treated wood had a higher residual mass when subjected to 500 ºC. Conclusion: Heat-treated wood can be indicated for products used in external environments, such as floors, fences, coatings, door and window structures.

https://doi.org/10.1590/01047760202329013264

Effects of grouped versus alternating functional training on the shoulder girdle and lumbar-pelvic girdle stability: a randomised controlled trial
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Silva-Grigoletto, Marzo E. da

; Aragão-Santos, José C.

; Fontes, Alan S.

; Santos, Marta S.

; Resende-Neto, Antônio G.

; Monteiro, Marcos Raphael Pereira

; Cyrino, Edilson S.

; Marin, Pedro J.

; Behm, David G.

Motricidade

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Dic 2022, Volumen 18 Nº 2 Paginas 237 - 245

Resumen: En | Texto: En | PDF: En

ABSTRACT The present research aimed to verify the effect of 10 weeks of structured FT grouped by muscular actions (GFT) or alternating actions (AFT) on scapular and lumbar-pelvic girdle stability. One hundred and twenty adults (60 men; 60 women) were allocated into three groups, GFT (n= 40) that performed the actions in sequence (squat - squat - pull - pull), AFT (n= 40) that performed alternate actions (squat - pull - squat - pull) and the control group (CG, n= 40). The shoulder girdle and pelvic girdle stability were assessed using the Octobalance Upper Body Test. The GFT increased stability after the intervention and compared to the CG (p= 0.003) as assessed by the relative range of the right (ES= 0.53) and left (ES= 0.57) hemispheres. Besides, most results were within the instrument’s error value and the magnitude of the effect was moderate to trivial among the experimental groups. Therefore, ten weeks of functional training performed in a grouped sequence promoted improvements in scapular and lumbar-pelvic girdle stability.

https://doi.org/10.6063/motricidade.27292

Testes Ergométricos em Pacientes com Anemia Falciforme: Segurança, Viabilidade e Possíveis Implicações no Prognóstico
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Araújo, Christiano Gonçalves de

; Resende, Maria Betânia Solis

; Tupinambás, Julia Teixeira

; Dias, Rebeca Coeli Teodoro Maciel

; Barros, Flávio Coelho

; Vasconcelos, Maria Carmen Melo

; Januário, José Nelio

; Ribeiro, Antonio Luiz Pinho

; Nunes, Maria Carmo P.

Arquivos Brasileiros de Cardiologia

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Mar 2022, Volumen 118 Nº 3 Paginas 565 - 575

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento Pacientes com anemia falciforme (AF) têm risco aumentado de complicações cardiovasculares. O teste ergométrico é usado como marcador de prognóstico em uma série de doenças cardiovasculares. Entretanto, há uma escassez de evidências sobre exercícios em pacientes com AF, especialmente em relação à sua segurança, viabilidade e possível função prognóstica. Objetivos Usamos o teste em esteira máximo para determinar a segurança e a viabilidade do teste ergométrico em pacientes com AF. Além disso, os fatores associados à duração do exercício, bem como o impacto das alterações causadas pelo exercício em resultados clínicos, também foram avaliados. Métodos 113 pacientes com AF que passaram pelo teste ergométrico e por uma avaliação cardiovascular abrangente incluindo um ecocardiograma e os níveis do peptídeo natriurético do tipo B (BNP). O desfecho de longo prazo foi uma combinação de eventos incluindo morte, crises álgicas graves, síndrome torácica aguda ou internações hospitalares por outras complicações associadas â doença falciforme. A análise de regressão de Cox foi realizada para identificar as variáveis associadas ao resultado. Um p valor <0,05 foi considerado estatisticamente significativo. Resultados A média de idade foi de 36 ± 12 anos (intervalo, 18-65 anos), e 62 pacientes eram do sexo feminino (52%). A presença de alterações isquêmicas ao esforço e resposta pressórica anormal ao exercício foram detectadas em 17% e 9 % da´população estudada respectivamente. Dois pacientes apresentaram crise álgica com necessidade de internação hospitalar no período de 48 horas da realização do exame. Fatores associados à duração do exercício foram idade, sexo, velocidade máxima de regurgitação tricúspide (RT), e relação E/e’, após a padronização quanto aos marcadores da gravidade da doença. Durante o período médio de acompanhamento de 10,1 meses (variando de 1,2 a 26), 27 pacientes (23%) apresentaram desfechos clínicos adversos. Preditores independentes de eventos adversos foram a concentração de hemoglobina, velocidade do fluxo transmitral tardio (onda A), e a resposta da PA ao exercício. Conclusões A realização de testes ergométricos em pacientes com AF, clinicamente estáveis, é viável. A duração do exercício estava associada à função diastólica e a pressão arterial pulmonar. A resposta anormal da PA foi um preditor independente de eventos adversos.

Abstract Background Patients with sickle cell disease (SCD) are at increased risk for cardiovascular complications. Exercise testing is used as a prognostic marker in a variety of cardiovascular diseases. However, there is a lack of evidence on exercise in SCD patients, particularly regarding its safety, feasibility, and possible prognostic role. Objectives We used the maximal treadmill test to determine safety and feasibility of the exercise testing in SCD patients. Additionally, the factors associated with exercise duration, as well as the impact of exercise-induced changes on clinical outcome, were also assessed. Methods One-hundred thirteen patients with SCD, who underwent exercise testing, were prospectively enrolled. A comprehensive cardiovascular evaluation, including echocardiography and B-type natriuretic peptide (BNP) levels, were obtained. The long-term outcome was a composite endpoint of death, severe acute painful episodes, acute chest syndrome, or hospitalization for other SCD-related complications. Cox regression analysis was performed to identify the variables associated with the outcome. A p-value<0.05 was considered to be statistically significant. Results The mean age was 36 ± 12 years (range, 18-65 years), and 62 patients were women (52%). Ischemic electrocardiogram and abnormal blood pressure (BP) response to exercise were detected in 17% and 9%, respectively. Two patients experienced pain crises within 48 hours that required hospitalization. Factors associated with exercise duration were age, sex, tricuspid regurgitation (TR) maximal velocity, and E/e’ ratio, after adjustment for markers of disease severity. During the mean follow-up of 10.1 months (ranging from 1.2 to 26), the endpoint was reached in 27 patients (23%). Independent predictors of adverse events were hemoglobin concentration, late transmitral flow velocity (A wave), and BP response to exercise. Conclusions Exercise testing in SCD patients who were clinically stable is feasible. Exercise duration was associated with diastolic function and pulmonary artery pressure. Abnormal BP response was an independent predictor of adverse events.

https://doi.org/10.36660/abc.20200437

Guidelines on COVID-19 vaccination in patients with immune-mediated rheumatic diseases: a Brazilian Society of Rheumatology task force
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Tavares, Anna Carolina Faria Moreira Gomes

; Melo, Ana Karla Guedes de

; Cruz, Vítor Alves

; Souza, Viviane Angelina de

; Carvalho, Joana Starling de

; Machado, Ketty Lysie Libardi Lira

; Valadares, Lilian David de Azevedo

; Reis Neto, Edgard Torres dos

; Rezende, Rodrigo Poubel Vieira de

; Guimarães, Maria Fernanda Brandão de Resende

; Ferreira, Gilda Aparecida

; Braz, Alessandra de Sousa

; Vieira, Rejane Maria Rodrigues de Abreu

; Pinheiro, Marcelo de Medeiros

; Ribeiro, Sandra Lúcia Euzébio

; Bica, Blanca Elena Gomes Rios

; Baptista, Kátia Lino

; Costa, Izaias Pereira da

; Marques, Claudia Diniz Lopes

; Lopes, Maria Lúcia Lemos

; Martinez, José Eduardo

; Giorgi, Rina Dalva Neubarth

; Mota, Lícia Maria Henrique da

; Loures, Marcos Antônio Araújo da Rocha

; Paiva, Eduardo dos Santos

; Monticielo, Odirlei André

; Xavier, Ricardo Machado

; Kakehasi, Adriana Maria

; Pileggi, Gecilmara Cristina Salviato

Advances in Rheumatology

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2022, Volumen 62 elocation 3

Resumen: En | Texto: En | PDF: En

Abstract Objective: To provide guidelines on the coronavirus disease 2019 (COVID-19) vaccination in patients with immune-mediated rheumatic diseases (IMRD) to rheumatologists considering specific scenarios of the daily practice based on the shared-making decision (SMD) process. Methods: A task force was constituted by 24 rheumatologists (panel members), with clinical and research expertise in immunizations and infectious diseases in immunocompromised patients, endorsed by the Brazilian Society of Rheumatology (BSR), to develop guidelines for COVID-19 vaccination in patients with IMRD. A consensus was built through the Delphi method and involved four rounds of anonymous voting, where five options were used to determine the level of agreement (LOA), based on the Likert Scale: (1) strongly disagree; (2) disagree, (3) neither agree nor disagree (neutral); (4) agree; and (5) strongly agree. Nineteen questions were addressed and discussed via teleconference to formulate the answers. In order to identify the relevant data on COVID-19 vaccines, a search with standardized descriptors and synonyms was performed on September 10th, 2021, of the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and LILACS to identify studies of interest. We used the Newcastle–Ottawa Scale to assess the quality of nonrandomized studies. Results: All the nineteen questions-answers (Q&A) were approved by the BSR Task Force with more than 80% of panelists voting options 4—agree—and 5—strongly agree—, and a consensus was reached. These Guidelines were focused in SMD on the most appropriate timing for IMRD patients to get vaccinated to reach the adequate covid-19 vaccination response. Conclusion: These guidelines were developed by a BSR Task Force with a high LOA among panelists, based on the literature review of published studies and expert opinion for COVID-19 vaccination in IMRD patients. Noteworthy, in the pandemic period, up to the time of the review and the consensus process for this document, high-quality evidence was scarce. Thus, it is not a substitute for clinical judgment.

https://doi.org/10.1186/s42358-022-00234-7

Development of microsatellite panels for molecular fingerprinting of Napier grass (Cenchrus purpureus) cultivars
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Azevedo, Ana Luisa Sousa

; Souza, Flávia Rangel de

; Campos, Rosiana Angélica

; Reis, Daniele Ribeiro de Lima

; Machado, Juarez Campolina

; Machado, Marco Antonio

; Lédo, Francisco José da Silva

; Resende, Marcio

Crop Breeding and Applied Biotechnology

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2022, Volumen 22 Nº 4 elocation e42522244

Resumen: En | Texto: En | PDF: En

Abstract Napier grass is a perennial tropical forage that is used in beef and dairy production systems. Despite its significance in animal nutrition, molecular information available, such as microsatellite or simple sequence repeat (SSR) or single nucleotide polymorphism (SNP) markers, is limited. Using an assembled transcriptome, 50 novel SSR markers were developed, of which 21 were found to be polymorphic. These polymorphic markers were tested for DNA fingerprinting of Embrapa cultivars, five of which revealed distinct allele patterns for cultivar identification. SSR markers 05, 17, and 44 identified a unique pattern in the BRS Kurumi cultivar. The BRS Capiaçu cultivar was identified using SSR markers 17, 43, and 44. The Pioneiro cultivar exhibited a rare fragment amplification pattern using SSR marker 46, while SSR marker 44 revealed a distinct allele in the BRS Canará cultivar. SSR marker panels could be utilized as DNA fingerprinting tools to assist in cultivar identification.

https://doi.org/10.1590/1984-70332022v22n4n39

Spinocerebellar ataxia type 3 presenting simultaneously with motor neuron disease and cerebellar ataxia
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Jaques, Cristina Saade

; Pedroso, José Luiz

; Rocha, Antônio José da

; Pinto, Wladimir Bocca Vieira de Resende

; Oliveira, Acary Souza Bulle

; Barsottini, Orlando G. P.

Arquivos de Neuro-Psiquiatria

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Sep 2021, Volumen 79 Nº 9 Paginas 851 - 852

Resumen: En | Texto: En | PDF: En

https://doi.org/10.1590/0004-282x-anp-2020-0189 139 descargas

Computed Tomography Colonography as a Sensible Option for Colorectal Cancer Screening: Evidence Based on Metanalysis
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Borges, Ingrid Chaves de Souza

; Cunha, Natália Costa Resende

; Rassi, Amanda Marsiaj

; Oliveira, Marcela Garcia de

; Leão-Cordeiro, Jacqueline Andréia Bernardes

; Ataides, Fábio Silvestre

; Almeida, Rogério José

; Vilanova-Costa, Cesar Augusto Sam Tiago

; Silva, Antonio Márcio Teodoro Cordeiro

Journal of Coloproctology (Rio de Janeiro)

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Mar 2021, Volumen 41 Nº 1 Paginas 87 - 95

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Esta meta-análise teve como objetivo avaliar a sensibilidade e especificidade da colonografia por tomografia computadorizada na detecção de pólipos colorretais. Métodos Foi realizada uma pesquisa bibliográfica nas bases de dados da PubMed e da Web of Science. Resultados Um total de 1.872 pacientes, 57,2% homens e 42,8% mulheres, com idades entre 49 a 82 anos de idade (média de 59,7 ± 5,3 anos) foram incluídos nesta meta análise. A sensibilidade da colonografia por tomografia computadorizada foi estimada em 88,4% (46,3-95,7%; coeficiente de variância [CV]=28,5%) e a especificidade em 73,6% (47,4%-100,0%; CV=37,5%). Para lesões de até 9mm, a sensibilidade foi de 82,5% (62,0-99,9%; CV=25,1%) e a especificidade de 79,2% (32,0-98,0%; CV=22,9%). Para lesõesmaiores que 9mm, a sensibilidade foi de 90,2% (64,0-100,0%; CV=7,4%) e a especificidade de 94,7% (80,0-100,0%; CV=6,2%). Não houve diferença estatisticamente significante entre as sensibilidades por tamanho da lesão (p=0,0958), porém a especificidade foi maior em lesões acima de 9mm (p<0,0001). Conclusão A maioria dos estudos analisados no presente trabalho foi realizada antes de 2010, cerca de uma década depois que a colonografia por tomografia computadorizada passou a ser indicada como método de triagem pelas diretrizes europeias e americanas. Portanto, são necessários mais estudos com o objetivo de analisar a técnica apósmaiores avanços tecnológicos, o que poderia levar ao desenvolvimento de dispositivos mais modernos.

Abstract Objective This metanalysis aimed to evaluate the sensitivity and specificity of computed tomography colonography in colorectal polyp detection. Methods A literature search was performed in the PubMed and Web of Science databases. Results A total of 1,872 patients (males 57.2%, females 42.8%) aged 49 to 82 years old (mean age 59.7 ± 5.3 years) were included in this metanalysis. The estimated sensitivity of computed tomography colonography was 88.4% (46.3-95.7%, coefficient of variation [CV]=28.5%) and the estimated specificity was 73.6% (47.4-100.0%, CV=37.5%). For lesions up to 9mm, the sensitivity was 82.5% (62.0-99.9%, CV =25.1%) and the specificity was 79.2% (32.0-98.0%, CV=22.9%). For lesions>9mm, the sensitivity was 90.2% (64.0-100.0%, CV=7.4%) and the specificity was 94.7% (80.0-100.0%, CV=6.2%). No statistically significant differences in sensitivity according to the size of the lesion were found (p=0.0958); however, the specificity was higher for lesions>9mm (p<0.0001). Conclusions Most of the studies analyzed in the present work were conducted before 2010, which is about a decade after computed tomography colonography started being indicated as a screening method by European and American guidelines. Therefore, more studies aimed at analyzing the technique after further technological advancements are necessary, which could lead to the development of more modern devices.

https://doi.org/10.1055/s-0041-1726079 85 descargas

BRAZILIAN CONSENSUS ON INCIDENTAL GALLBLADDER CARCINOMA
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COIMBRA, Felipe Jose F

; TORRES, Orlando Jorge M

; ALIKHANOV, Ruslan

; AGARWAL, Anil

; PESSAUX, Patrick

; FERNANDES, Eduardo de Souza M

; QUIREZE-JUNIOR, Claudemiro

; ARAUJO, Raphael Leonardo C

; GODOY, André Luis

; WAECHTER, Fabio Luis

; RESENDE, Alexandre Prado de

; BOFF, Marcio Fernando

; COELHO, Gustavo Rego

; REZENDE, Marcelo Bruno de

; LINHARES, Marcelo Moura

; BELOTTO, Marcos

; MORAES-JUNIOR, Jose Maria A

; AMARAL, Paulo Cezar G

; PINTO, Rinaldo Danesi

; GENZINI, Tercio

; LIMA, Agnaldo Soares

; RIBEIRO, Heber Salvador C

; RAMOS, Eduardo José

; ANGHINONI, Marciano

; PEREIRA, Lucio Lucas

; ENNE, Marcelo

; SAMPAIO, Adriano

; MONTAGNINI, André Luis

; DINIZ, Alessandro

; JESUS, Victor Hugo Fonseca de

; SIROHI, Bhawna

; SHRIKHANDE, Shailesh V

; PEIXOTO, Renata D`Alpino

; KALIL, Antonio Nocchi

; JARUFE, Nicolas

; SMITH, Martin

; HERMAN, Paulo

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2020, Volumen 33 Nº 1 elocation e1496

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Racional: Carcinoma incidental da vesícula biliar é definido como uma neoplasia descoberta por exame histológico após colecistectomia videolaparoscópica. É potencialmente uma doença curável. Entretanto algumas questões relacionadas ao seu manuseio permanecem controversas e uma estratégia definida está associada com melhor prognóstico. Objetivo: Desenvolver o primeiro consenso baseado em evidências para o manuseio de pacientes com carcinoma incidental da vesícula biliar no Brasil. Métodos: Dezesseis questões foram selecionadas e para responder as questões e 36 membros das sociedades brasileiras e internacionais foram incluídos. As recomendações foram baseadas em evidências da literatura atual. Um relatório final foi enviado para os membros do painel para avaliação de concordância. Resultados: Avaliação intraoperatória da peça cirúrgica, uso de bolsas para retirar a peça cirúrgica e exame histopatológico de rotina, foram recomendados. Avaliação pré-operatória completa é necessária e deve ser realizada assim que o estadiamento final esteja disponível. Avaliação da margem do ducto cístico e biópsia de rotina do linfonodo 16b1 são recomendadas. Quimioterapia deve ser considerada e quimioradioterapia indicada se a margem cirúrgica microscópica seja positiva. Os portais devem ser ressecados excepcionalmente. O estadiamento laparoscópico antes da operação é recomendado, mas o tratamento radical por abordagem minimamente invasiva deve ser realizado apenas em centros especializados em cirurgia hepatopancreatobiliar minimamente invasiva. A extensão da ressecção hepática é aceitável até que seja alcançada a ressecção R0. A linfadenectomia padrão é indicada para tumores iguais ou superiores a T2, mas a ressecção da via biliar não é recomendada de rotina. Conclusões: Recomendações seguras foram preparadas para carcinoma incidental da vesícula biliar, destacando os mais frequentes tópicos do trabalho diário do cirurgião do aparelho digestivo e hepatopancreatobiliar.

ABSTRACT Background: Incidental gallbladder cancer is defined as a cancer discovered by histological examination after cholecystectomy. It is a potentially curable disease. However, some questions related to their management remain controversial and a defined strategy is associated with better prognosis. Aim: To develop the first evidence-based consensus for management of patients with incidental gallbladder cancer in Brazil. Methods: Sixteen questions were selected, and 36 Brazilian and International members were included to the answer them. The statements were based on current evident literature. The final report was sent to the members of the panel for agreement assessment. Results: Intraoperative evaluation of the specimen, use of retrieval bags and routine histopathology is recommended. Complete preoperative evaluation is necessary and the reoperation should be performed once final staging is available. Evaluation of the cystic duct margin and routine 16b1 lymph node biopsy is recommended. Chemotherapy should be considered and chemoradiation therapy if microscopically positive surgical margins. Port site should be resected exceptionally. Staging laparoscopy before reoperation is recommended, but minimally invasive radical approach only in specialized minimally invasive hepatopancreatobiliary centers. The extent of liver resection is acceptable if R0 resection is achieved. Standard lymph node dissection is required for T2 tumors and above, but common bile duct resection is not recommended routinely. Conclusions: It was possible to prepare safe recommendations as guidance for incidental gallbladder carcinoma, addressing the most frequent topics of everyday work of digestive and general surgeons.

https://doi.org/10.1590/0102-672020190001e1496 2194 descargas

Selection gains for bunch production in interspecific hybrids between “caiaué” and oil palm
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Gomes Junior, Rui Alberto

; Lopes, Ricardo

; Cunha, Raimundo Nonato Vieira da

; Pina, Antônio José de Abreu

; Quaresma, Carlos Edmundo

; Campelo, Raqueline Dias

; Resende, Marcos Deon Vilela de

Pesquisa Agropecuária Brasileira

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2019, Volumen 54 elocation e00819

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi estimar ganhos de seleção para produção de cachos em híbridos obtidos de genitores caiaué (Elaeis oleifera) da população Manicoré e dendê (Elaeis guineensis) da população La Mé, do terceiro ao oitavo ano após o plantio. Avaliaram-se 39 progênies de irmãos completos em experimentos conduzidos em delineamento de blocos ao acaso, com quatro repetições e 12 plantas por parcela. As estimativas de ganho genético foram de 27,6% para a seleção dos dez melhores indivíduos F1, 13,7% para a seleção das quatro melhores progênies de genitores de ambos os sexos, 6,4% para a seleção das progênies dos cinco melhores genitores masculinos, 6,0% para a seleção das progênies das duas melhores famílias de genitores masculinos e 4,0% para a seleção das progênies da melhor descendência de genitores masculinos. É possível obter ganhos genéticos para produção de cachos, em curto prazo, com a seleção restrita a genitores masculinos, e, em médio prazo, com a seleção de genitores masculinos e femininos e com a clonagem de indivíduos F1.

Abstract: The objective of this work was to estimate selection gains for bunch production in hybrids obtained from “caiaué” (Elaeis oleifera) parents from the Manicoré population and oil palm (Elaeis guineensis) parents from the La Mé population, from the third to the eighth year after planting. Thirty-nine full-sibling progenies were evaluated in experiments conducted in a randomized complete block design, with four replicates and 12 plants per plot. The genetic gain estimates were 27.6% for the ten best selected F1 individuals, 13.7% for the four best selected progenies from parents of both sexes, 6.4% for the selected progenies of the five best male parents, 6.0% for the selected progenies of the two best families from male parents, and 4.0% for the selected progenies of the best descendants from male parents. Genetic gains for bunch production can be achieved, in the short term, through selection restricted to male parents, and, in the medium term, through selection of both male and female parents and cloning of F1 individuals.

https://doi.org/10.1590/s1678-3921.pab2019.v54.00819 293 descargas

10.

Avaliação da interleucina 3 como marcador prognóstico na sepse
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Borges, Isabela Nascimento

; Resende, Carolina Braga

; Vieira, Érica Leandro Marciano

; Silva, José Luiz Padilha da

; Andrade, Marcus Vinícius Melo de

; Souza, Andrea Jerusa de

; Badaró, Eurípedes

; Carneiro, Rafael Mourão

; Teixeira Jr., Antônio Lúcio

; Nobre, Vandack

Revista Brasileira de Terapia Intensiva

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Dic 2018, Volumen 30 Nº 4 Paginas 443 - 452

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a acurácia dos níveis de interleucina 3 para predizer prognóstico em pacientes sépticos. Métodos: Conduzimos uma coorte prospectiva que incluiu pacientes adultos internados em unidade de terapia intensiva, que apresentassem sepse ou choque séptico iniciados há até 48 horas. Mediram-se os níveis séricos de interleucina 3 quando da inclusão (dia 1) e nos dias 3 e 7. O desfecho primário analisado foi a mortalidade hospitalar por qualquer causa. Resultados: Foram incluídos 120 pacientes. Os níveis séricos de interleucina 3 dosados à inclusão foram significativamente mais elevados em pacientes que faleceram em comparação aos que sobreviveram à internação hospitalar (91,2pg/mL versus 36pg/mL; p = 0,024). Em modelo de sobrevivência de Cox com inclusão de idade e valores sequenciais de SOFA, os níveis de interleucina 3 mensurados na inclusão mantiveram-se independentemente associados à mortalidade hospitalar (HR 1,032; IC95% 1,010 - 1,055; p = 0,005). Em curva Característica de Operação do Receptor construída para investigação adicional da acurácia da interleucina 3 na predição do prognóstico, encontrou-se área sob a curva de 0,62 (IC95% 0,51 - 0,73; p = 0,024) para mortalidade hospitalar. Valores iniciais de interleucina 3 acima de 127,5pg/mL mostraram-se significativamente associados à mortalidade hospitalar (p = 0,019; OR = 2,97; IC95% 1,27 - 6,97; p = 0,019), entretanto com baixo desempenho (especificidade de 82%, sensibilidade de 39%, valor preditivo positivo de 53%, valor preditivo negativo de 72%, razão de verossimilhança negativa de 0,73 e razão de verossimilhança positiva de 2,16). Conclusão: Níveis elevados de interleucina 3 mostraram-se independentemente associados à mortalidade hospitalar em pacientes sépticos, entretanto com baixo desempenho clínico.

ABSTRACT Objective: To evaluate the accuracy of IL-3 to predict the outcome of septic patients. Methods: Prospective cohort study with adult patients in an intensive care unit with sepsis or septic shock diagnosed within the previous 48 hours. Circulating IL-3 levels were measured upon inclusion (day 1) and on days 3 and 7. The primary outcome was hospital mortality. Results: One hundred and twenty patients were included. Serum levels of IL-3 on day 1 were significantly higher among patients who died than among patients who survived the hospital stay (91.2pg/mL versus 36pg/mL, p = 0.024). In a Cox survival model considering the IL-3 levels at inclusion, age and sequential SOFA, IL-3 values remained independently associated with mortality (HR 1.032; 95%CI 1.010 - 1.055; p = 0.005). An receiver operating characteristic curve was built to further investigate the accuracy of IL-3, with an area under the curve of 0.62 (95%CI 0.51 - 0.73; p = 0.024) for hospital mortality. A cutoff initial IL-3 value above 127.5pg/mL was associated with hospital mortality (OR 2.97; 95%CI: 1.27 - 6.97; p = 0.0019) but with a low performance (82% for specificity, 39% for sensibility, 53% for the positive predictive value, 72% for the negative predictive value, 0.73 for the negative likelihood and 2.16 for the positive likelihood ratio). Conclusion: Higher levels of IL-3 are shown to be independently associated with hospital mortality in septic patients but with poor clinical performance.

https://doi.org/10.5935/0103-507x.20180064 1263 descargas

11.

Parâmetros e tendências genéticas para peso ao sobreano de animais Nelore criados no estado do Paraná, Brasil
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Souza, Júlio Cesar de

; Resende, Marcos Paulo Gonçalves de

; Silva, Luiz Otavio Campos da

; Gusmão, Marco

; Gondo, Andrea

; Mota, Marcelo Falci

; Freitas, José Antonio

; Silva, Rosana Moreira da

Revista colombiana de ciencia animal recia

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Jun 2018, Volumen 10 Nº 1 Paginas 68 - 73

Resumen: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Environmental effects and genetic parameters were estimated for weights at 365 and 550 days for Nellore cattle raised in the Parana State. Least Squared Means methodology, was used to estimate environmental effects. The model included as fixed effects year and month of birth calf, sex and age of dam at calving as a covariate and error as random effects. The variance components were estimated using an animal model considered as fixed effects contemporary group and age of dam. As random effect were composite of direct and maternal genetic additive effects and permanent environment. The genetic trends for direct and maternal effects were estimated by the regression of annual breeding value means on the animals’ year of birth. The heritability were 0.24±0.03 and 0.35±0.05 for direct genetic effect and 0.08±0.03 and 0.03±0.04 for maternal heritability for weights at 365 and 550 days, respectively. The genetic trends of the direct and maternal effects were 0.506 kg/year and -0.184 kg/year for weights at 365 days; and 0.712 kg/year and 0.187 kg/year for weights at 550 days. The results indicate the existence of adequate genetic variability to enable successful selection of breeding stock and realization of genetic gain.

RESUMO Objetivou-se avaliar os efeitos de meio e estimar os parâmetros e tendência genética para peso aos 365 e 550 dias de animais da raça Nelore criados no estado do Paraná. Utilizou-se do método dos quadrados mínimos, incluindo os efeitos fixos de ano, mês de nascimento, sexo e a co-variável idade da vaca ao parto (linear e quadrática). Os parâmetros genéticos foram estimados utilizando-se um modelo animal que continha os efeitos aleatórios genéticos direto e materno, de ambiente permanente e o erro; além do efeito fixo de grupo contemporâneo e da co-variável idade da vaca ao parto. A tendência genética foi obtida por meio de análise de regressão linear do valor genético do animal sobre o ano de nascimento. As herdabilidades diretas foram 0,24±0,03 e 0,35±0,05; as herdabilidades maternas foram 0,08±0,03 e 0,03±0,04, para peso aos 365 e 550 dias, respectivamente. As tendências genéticas direta e materna foram 0,506 kg/ano e -0,184 kg/ano para P365; e 0,712 kg/ano e 0,187 kg/ano para P550. Os resultados indicam a existência de variabilidade genética o que possibilitam ganhos através de seleção.

https://doi.org/10.24188/recia.v10.n1.2018.632 226 descargas

12.

Early selection and classification of yerba mate progênies
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Wendling, Ivar

; Sturion, José Alfredo

; Stuepp, Carlos André

; Reis, Cristiane Aparecida Fioravante

; Ramalho, Magno Antonio Patto

; Resende, Marcos Deon Vilela de

Pesquisa Agropecuária Brasileira

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Mar 2018, Volumen 53 Nº 3 Paginas 279 - 286

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi avaliar a viabilidade da seleção precoce de progênies de polinização aberta de erva-mate (Ilex paraguariensis) e classificar os melhores genitores e candidatos a clones. O germoplasma é composto por 140 progênies coletadas em áreas de distribuição natural da espécie na região Sul do Brasil e um genótipo comercial (testemunha). O experimento foi implantado em Ivaí, PR, em março de 1997, em blocos ao acaso, com dez repetições, e parcelas lineares de seis plantas. A massa comercial (kg por planta) com folhas e galhos menores que 7 mm foi colhida aos 2,5, 4,5, 6,5 e 18,7 anos de idade. A avaliação estatística foi realizada por meio do procedimento de modelos mistos com máxima verossimilhança restrita/melhor predição linear não viesada, por meio do programa Selegen. Elevada acurácia seletiva, efeitos significativos de progênies e variabilidade genética para a produção de massa comercial foram observados nas quatro idades de colheitas. A aplicação da seleção precoce para a produção de massa foliar é viável para as progênies na colheita aos 6,5 anos. A seleção das melhores árvores, seja para uso como genitoras em cruzamentos ou como candidatas à clonagem, proporciona ganhos significativos para o melhoramento de erva-mate.

Abstract: The objective of this work was to evaluate the feasibility of early selection of open-pollinated yerba mate (Ilex paraguariensis) progenies, and to classify the best parents and candidates for clones. The germplasm is composed of 140 progenies collected from areas within the natural distribution of the species in Southern Brazil and a commercial genotype (control). The experiment was established in Ivaí, in the state of Paraná, Brazil, in March 1997, in randomized complete blocks, with ten replicates, and linear plots of six plants. The commercial mass (kg per plant) of leaves and branches smaller than 7 mm was harvested at 2.5, 4.5, 6.5, and 18.7 years of age. The statistical evaluation was performed using the mixed model procedure with restricted maximum likelihood/best linear unbiased prediction, using the Selegen software. High selective accuracy, significant progeny effects, and genetic variability for commercial mass production were observed for the four harvesting ages. The application of early selection for leaf mass production is feasible for yerba mate progenies harvested at 6.5 years. The selection of the best trees, either for use as parents or as candidates for cloning, provides significant gains for the genetic breeding of yerba mate.

https://doi.org/10.1590/s0100-204x2018000300002 818 descargas

13.

Unilateral spatial neglect in the acute phase of ischemic stroke can predict long-term disability and functional capacity
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Luvizutto, Gustavo José

; Moliga, Augusta Fabiana

; Rizzatti, Gabriela Rizzo Soares

; Fogaroli, Marcelo Ortolani

; Moura Neto, Eduardo de

; Nunes, Hélio Rubens de Carvalho

; Resende, Luiz Antônio de Lima

; Bazan, Rodrigo

Clinics

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2018, Volumen 73 elocation e131

Resumen: En | Texto: En | PDF: En

OBJECTIVE: The aim of this study was to assess the relationship between the degree of unilateral spatial neglect during the acute phase of stroke and long-term functional independence. METHODS: This was a prospective study of right ischemic stroke patients in which the independent variable was the degree of spatial neglect and the outcome that was measured was functional independence. The potential confounding factors included sex, age, stroke severity, topography of the lesion, risk factors, glycemia and the treatment received. Unilateral spatial neglect was measured using the line cancellation test, the star cancellation test and the line bisection test within 48 hours of the onset of symptoms. Functional independence was measured using the modified Rankin and Barthel scales at 90 days after discharge. The relationship between unilateral spatial neglect and functional independence was analyzed using multiple logistic regression that was corrected for confounding factors. RESULTS: We studied 60 patients with a median age of 68 (34-89) years, 52% of whom were male and 74% of whom were Caucasian. The risk for moderate to severe disability increased with increasing star cancellation test scores (OR=1.14 [1.03-1.26], p=0.01) corrected for the stroke severity, which was a confounding factor that had a statistically positive association with disability (OR=1.63 [1.13-2.65], p=0.01). The best chance of functional independence decreased with increasing star cancellation test scores (OR=0.86 [0.78-0.96], p=0.006) corrected for the stroke severity, which was a confounding factor that had a statistically negative association with independence (OR=0.66 [0.48-0.92], p=0.017). CONCLUSION: The severity of unilateral spatial neglect in acute stroke worsens the degree of long-term disability and functional independence.

https://doi.org/10.6061/clinics/2018/e131 1159 descargas

14.

Standardization of the face-hand test in a Brazilian multicultural population: prevalence of sensory extinction and implications for neurological diagnosis
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Luvizutto, Gustavo José

; Fogaroli, Marcelo Ortolani

; Theotonio, Rodolfo Mazeto

; Nunes, Hélio Rubens de Carvalho

; Resende, Luiz Antônio de Lima

; Bazan, Rodrigo

Clinics

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Dic 2016, Volumen 71 Nº 12 Paginas 720 - 724

Resumen: En | Texto: En | PDF: En

OBJECTIVE: The face-hand test is a simple, practical, and rapid test to detect neurological syndromes. However, it has not previously been assessed in a Brazilian sample; therefore, the objective of the present study was to standardize the face-hand test for use in the multi-cultural population of Brazil and identify the sociodemographic factors affecting the results. METHODS: This was a cross sectional study of 150 individuals. The sociodemographic variables that were collected included age, gender, race, body mass index and years of education. Standardization of the face-hand test occurred in 2 rounds of 10 sensory stimuli, with the participant seated to support the trunk and their vision obstructed in a sound-controlled environment. The face-hand test was conducted by applying 2 rounds of 10 sensory stimuli that were applied to the face and hand simultaneously. The associations between the face-hand test and sociodemographic variables were analyzed using Mann-Whitney tests and Spearman correlations. Binomial models were adjusted for the number of face-hand test variations, and ROC curves evaluated sensitivity and specificity of sensory extinction. RESULTS: There was no significant relationship between the sociodemographic variables and the number of stimuli perceived for the face-hand test. There was a high relative frequency of detection, 8 out of 10 stimuli, in this population. Sensory extinction was 25.3%, which increased with increasing age (OR=1.4[1:01–1:07]; p=0.006) and decreased significantly with increasing education (OR=0.82[0.71-0.94]; p=0.005). CONCLUSION: In the Brazilian population, a normal face-hand test score ranges between 8–10 stimuli, and the results indicate that sensory extinction is associated with increased age and lower levels of education.

https://doi.org/10.6061/clinics/2016(12)08 681 descargas

15.

Artroplastia de Interposição com PyroDisc® no Tratamento da Rizartrose: Resultados a 5 anos
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Pinho, Romeu

; Neto, Artur

; Resende, Vera

; Teixeira, José Manuel

; Miranda, António

Revista Portuguesa de Ortopedia e Traumatologia

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Dic 2016, Volumen 24 Nº 4 Paginas 247 - 259

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Objectivo: A osteoartrose da articulação trapézio-metacarpiana tem uma elevada prevalência. Na falência do tratamento conservador, estão descritos vários procedimentos cirúrgicos, não tendo sido até à data provada a superioridade de nenhum deles. A artroplastia de interposição com PyroDisk® foi introduzida em 2005 e os poucos estudos existentes apresentam follow-ups curtos. O objectivo do presente estudo é avaliar os resultados clínicos e radiológicos da artroplastia de interposição com PyroDisk® a 5 anos. Material e Métodos: Realizámos um estudo retrospectivo, transversal e analitico, tendo como amostra os doentes submetidos a artroplastia de interposição com Pyrodisk® entre Janeiro de 2008 e Abril de 2010. Resultados: Foram avaliados 26 doentes correspondendo a 29 artroplastias. Verificámos um elevado grau de satisfação (92,3%) e obtivémos um reduzido grau de incapacidade para as actividades da vida diária (DASH médio 22,1), com um score médio de dor de 1,78. O score de Kapandji médio aos 5 anos foi 8,56. A força de preensão palmar média foi 13,0 kg/cm² e a força de pinça digital média foi de 4,5 Kg/ cm². Não se verificou relação estatisticamente significativa entre o grau de osteólise e os resultados clinicos a 5 anos (p > 0,05). Registámos 3 complicações (10,3%): 2 luxações e 1 neuroma do ramo sensitivo superficial. A sobrevivência do implante aos 5 anos foi de 93,1%. Conclusões: O nosso estudo confirma os bons resultados a 5 anos da artroplastia de interposição com Pyrodisk®. A lise verificada não comprometeu os resultados clínicos.

Objective: Trapeziometacarpal osteoarthritis has a high prevalence. In the failure of conservative treatment, there are described several surgical procedures, not having been proved to date the superiority of any of them. The PyroDisk® interposition implant was introduced in 2005 and the few existing studies have short follow-ups. The objective of this study is to evaluate the 5 year clinical and radiological results of interposition arthroplasty with PyroDisk®. Methods: We conducted a retrospective, cross-sectional analytical study, with a sample composed by patients undergoing interposition arthroplasty with Pyrodisk® between January 2008 and April 2010. Results: We evaluated 26 patients corresponding to 29 arthroplasties. We found a high degree of satisfaction (92.3%) and had a low degree of disability in daily living activities (average DASH 22.1), with an average pain score of 1.78. The average Kapandji score at 5 years was 8.56. The mean grip strength was 13.0 kg / cm² and key pinch strength was 4.5 kg / cm². There was no statistically significant relationship between the degree of osteolysis and the clinical results at 5 years (p >00,5). We registeredthree complications (10.3%): 2 dislocationsand 1 superficial sensory branch neuroma. The implant survival at 5 years was 93.1%. Conclusions: Our study confirms the good five year clinical results of interposition arthroplasty with Pyrodisk®. The observed lysis did not compromise the results.

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