Abstract With the growing demand for solutions to prevent and resolve faults in gas-insulated substations that affect the operation of the electrical system, a fault simulation laboratory for gas-insulated substations was developed to develop solutions for monitoring and locating these faults. The laboratory is composed of instruments for a fault location system based on traveling wave theory. The laboratory also has computational programs for fault simulation control and signal acquisition, in addition to having tools to analyze the data. The results were obtained through tests carried out that confirmed the laboratory's ability to simulate the operation of faults in gas-insulated substations, which allowed demonstrating the capacity of the fault location system using the theory of traveling waves.

Resumo O estudo objetivou investigar a prevalência de insegurança alimentar no contexto da COVID-19 e sua associação com o programa de transferência de renda Auxílio Emergencial e o recebimento de doação de alimentos na população em vulnerabilidade social. Estudo transversal, realizado com famílias em vulnerabilidade social, oito meses após a confirmação do primeiro caso de COVID-19 no Brasil. Foram incluídas 903 famílias, residentes em 22 aglomerados subnormais de Maceió, em Alagoas. Avaliaram-se características sociodemográficas e foi aplicada a Escala Brasileira de Insegurança Alimentar. A associação da insegurança alimentar com as variáveis estudadas foi realizada por meio de regressão de Poisson com estimativa robusta das variâncias, considerando α = 5%. Do total da amostra, 71,1% estavma em insegurança alimentar, situação que se associou com o recebimento de doação de alimentos (RP = 1,14, IC95%: 1,02; 1,27) e ser beneficiário do Auxílio Emergencial (RP = 1,23, IC95%: 1,01; 1,49). Os resultados mostram que a população em vulnerabilidade social foi fortemente afetada pela insegurança alimentar. Em contrapartida, essa população foi beneficiada por ações que foram implementadas no início da pandemia.

Abstract The scope of this study was to investigate the prevalence of food insecurity in the context of COVID-19 and its association with the emergency aid income-transfer program and the collecting of food donations by the population in a situation of social vulnerability. A cross-sectional study was carried out with socially vulnerable families eight months after confirming the first case of COVID-19 in Brazil. A total of 903 families, living in 22 underprivileged communities of Maceió, in the state of Alagoas, were included. Sociodemographic characteristics were evaluated, and the Brazilian Food Insecurity Scale was applied. The association of food insecurity with the variables studied was performed using Poisson regression with robust variance estimation, considering α = 5%. Of the total sample, 71.1% were food insecure, a situation associated with receiving food donations (PR = 1.14; 95%CI: 1.02; 1.27) and being a beneficiary of emergency aid (PR =1.23; 95%CI: 1.01; 1.49). The results show that the population in a situation of social vulnerability was strongly affected by food insecurity. On the other hand, the population group in question benefited from actions implemented at the outset of the pandemic.

Abstract The scope of this study was to investigate the prevalence of food insecurity in the context of COVID-19 and its association with the emergency aid income-transfer program and the collecting of food donations by the population in a situation of social vulnerability. A cross-sectional study was carried out with socially vulnerable families eight months after confirming the first case of COVID-19 in Brazil. A total of 903 families, living in 22 underprivileged communities of Maceió, in the state of Alagoas, were included. Sociodemographic characteristics were evaluated, and the Brazilian Food Insecurity Scale was applied. The association of food insecurity with the variables studied was performed using Poisson regression with robust variance estimation, considering α = 5%. Of the total sample, 71.1% were food insecure, a situation associated with receiving food donations (PR = 1.14; 95%CI: 1.02; 1.27) and being a beneficiary of emergency aid (PR =1.23; 95%CI: 1.01; 1.49). The results show that the population in a situation of social vulnerability was strongly affected by food insecurity. On the other hand, the population group in question benefited from actions implemented at the outset of the pandemic.

Resumo O estudo objetivou investigar a prevalência de insegurança alimentar no contexto da COVID-19 e sua associação com o programa de transferência de renda Auxílio Emergencial e o recebimento de doação de alimentos na população em vulnerabilidade social. Estudo transversal, realizado com famílias em vulnerabilidade social, oito meses após a confirmação do primeiro caso de COVID-19 no Brasil. Foram incluídas 903 famílias, residentes em 22 aglomerados subnormais de Maceió, em Alagoas. Avaliaram-se características sociodemográficas e foi aplicada a Escala Brasileira de Insegurança Alimentar. A associação da insegurança alimentar com as variáveis estudadas foi realizada por meio de regressão de Poisson com estimativa robusta das variâncias, considerando α = 5%. Do total da amostra, 71,1% estavma em insegurança alimentar, situação que se associou com o recebimento de doação de alimentos (RP = 1,14, IC95%: 1,02; 1,27) e ser beneficiário do Auxílio Emergencial (RP = 1,23, IC95%: 1,01; 1,49). Os resultados mostram que a população em vulnerabilidade social foi fortemente afetada pela insegurança alimentar. Em contrapartida, essa população foi beneficiada por ações que foram implementadas no início da pandemia.

Abstract Shielded substations with SF6 gas insulation (GIS) play a critical role in supplying power to urban areas, and it is crucial to quickly identify and isolate faults to restore system operation and meet supply demands. However, locating faults in such substations can involve extensive and time-consuming procedures, such as opening and closing hermetically sealed compartments containing SF6. This paper presents the development of an acoustic test bench that accurately replicates the dynamic characteristics of SF6 shielded substations. By utilizing the traveling wave technique, partial discharges occurring in high-voltage insulation can be detected and precisely located. The method employs various techniques, including the analysis of the arrival time of traveling waves at different points within the substation and triangulation methods. The use of traveling waves in partial discharge detection offers several advantages, such as precise fault location and non-interference with normal substation operations. Additionally, acoustic methods are highly sensitive to other sources of partial discharges, such as moving particles and fluctuating potential discharges. The results demonstrate that the combination of the acoustic test bench and the disturbance localization technique presents an innovative approach to fault location studies in GIS. The acoustic test bench enables controlled simulation of failure conditions, providing accurate data on the acoustic behavior of substations. Through the disturbance location technique, these data can be analyzed and interpreted to pinpoint the exact fault location. This integrated approach enhances the efficiency of the troubleshooting process and reduces the time required to repair GIS.

Abstract Objectives: evaluate the relationship between family’s food and nutrition insecurity (FNI) and the social network of malnourished children. Methods: cross-sectional study with 92 children, included in the economic class D-E. For the analysis of the children’s social network, the mothers answered four simple questions. To investigate the FNI, the Brazilian Scale of Food Insecurity was used. The association between variables was analyzed by Poisson regression with robust analysis of variances. Results: 56.5% of the children had a weak social network (<10 individuals), and the prevalence of FNI was 72.8%. An inverse association was observed between children of the daily social network and FNI family (OR=0.94; CI95%=0.89-0.99], p=0.03). The number of individuals in the children’s daily social network was negatively associated with the likelihood of FNI. The mother’s educational level was also related to FNI (OR=2.20 [CI95%=1.11-4.34]; p=0.02), being the child up to 2.2 times more likely to be in FNI when the mother has less than four years of study. Conclusion: these results suggest that social network is associated with the FNI of malnourished children. Interventions designed to strengthen instrumental and other forms of support among small social networks can improve the health/nutrition of malnourished children with FNI.

Resumo Objetivos: avaliar a relação entre a insegurança alimentar e nutricional (IAN) da família e a rede social de crianças desnutridas. Métodos: estudo transversal com 92 crianças, inseridas na classe econômica D-E. Para a análise da rede social das crianças, as mães responderam quatro perguntas simples. Para investigar a IAN foi utilizada a Escala Brasileira de Insegurança Alimentar. A associação entre as variáveis foi analisada por regressão de Poisson com análise robusta das variâncias. Resultados: 56,5% das crianças apresentaram rede social fraca (<10 indivíduos), e a prevalência de IAN foi de 72,8%. Foi observada uma associação inversa entre rede social diária das crianças e IAN da família (RP=0,94, [IC95%=0,89-0,99]; p=0,03). O número de indivíduos na rede social diária das crianças se associou negativamente com a probabilidade de IAN. O nível de escolaridade materno também estava relacionado com a IAN (RP=2,20 [IC95%=1,11-4,34]; p=0,02), tendo a criança até 2,2 vezes mais probabilidade de estar em IAN quando a mãe apresenta menos de quatro anos de estudo. Conclusão: esses resultados sugerem que a rede social está associada à IAN de crianças desnutridas. Intervenções destinadas a fortalecer maneiras instrumentais e outras formas de apoio entre pequenas redes sociais podem melhorar a saúde/nutrição de crianças desnutridas com IAN.

Biological collections are of extreme importance in acquiring knowledge of the biodiversity of a specific environment. In this article, we organise, list and catalogue the adult specimens belonging to the family Culicidae housed in the Parasitology Collection of the Basic Pathology Department at the Federal University of Paraná, southern Brazil. To this end, a data bank was created, containing information on the taxonomy and collecting of each sample. The culicids were collected using different methodologies in 18 municipalities in the state of Paraná, between 1967 and 1999. There are 5,739 catalogued specimens of which 4,704 (81.96%) are identified at a specific level, with a diversity of 205 species. Of these, 18 are new recorded samples for the state of Paraná and 3 for Brazil. This being the case, we propose, in honour of the 30 years dedicated to the study of culicids in the state of Paraná, the creation of the Ana Leuch Lozovei Entomological Collection, which is composed of insect vectors or potential vectors, of agents that cause diseases in humans.nbsp;

RESUMO CONTEXTO: Gastrite atrófica crônica por H. pylori constitui lesão pré-maligna e seu estadiamento de acordo com os sistemas OLGA e OLGIM, visa identificar pacientes com maior risco de desenvolver câncer gástrico e otimizar seu acompanhamento. GastroPanel® é um teste não invasivo composto por painel de biomarcadores séricos incluindo pepsinogênio I (PGI), pepsinogênio II (PGII), gastrina 17 (G17) e anticorpos anti- H. pylori para avaliação de risco de adenocarcinoma gástrico em pacientes com gastrite crônica por H. pylori. OBJETIVO: Estudo prospectivo para avaliar a concordância entre os sistemas de classificação OLGA e OLGIM, bem como avaliar o desempenho do GastroPanel® em pacientes com lesões pré-malignas secundárias à gastrite crônica por H. pylori no Brasil. MÉTODOS: Pacientes com gastrite crônica por H. pylori portadores de lesões pré-malignas confirmadas por histologia (gastrite atrófica e metaplasia intestinal) foram recrutados no ambulatório de gastroenterologia de um hospital universitário. Todos os participantes foram submetidos a exame endoscópico com biópsias de antro e corpo gástricos analisadas de acordo com o Sistema Sydney atualizado e estadiadas pelos Sistemas OLGA e OLGIM de classificação das gastrites. Amostras de sangue foram coletadas para análise sorológica de biomarcadores (GastroPanel®, Biohit, Helsinki, Finlândia). Os valores de corte utilizados para definir pacientes de alto risco para desenvolvimento de câncer gástrico foram os recomendados pelo fabricante: PGI ≤30 µm e PGI/PGII ≤3. RESULTADOS: Foram recrutados 41 pacientes: 28 mulheres, 13 homens, idade média 67,3 (47-89, DP: 9,6) anos. Pelo sistema OLGA, foram obtidos: OLGA 0 (n=1), OLGA I (n=7), OLGA II (n=17), OLGA III (n=9) e OLGA IV (n=7). Pelo sistema OLGIM, foram obtidos: OLGIM 0 (n=14), OLGIM I (n=5), OLGIM II (n=10), OLGIM III (n=10) e OLGIM IV (n=2). Em relação ao estadiamento histológico entre os pacientes de baixo risco (OLGA/OLGIM 0, I e II) e alto risco (OLGA/OLGIM III e IV) para o desenvolvimento de câncer gástrico, a taxa de concordância encontrada entre as duas classificações foi de 85,4%, com valor kappa=0,678 (IC95%: 0,440-0,916). Considerando como pacientes de alto risco, aqueles assim estadiados em pelo menos um dos sistemas, a distribuição final de nossa amostra encontrou 24 pacientes de baixo risco e 17 de alto risco para o desenvolvimento de câncer gástrico. Na determinação pelo GastroPanel® para classificação do paciente como de baixo ou alto risco para desenvolvimento de câncer gástrico, PGI mostrou sensibilidade, especificidade e acurácia de 0,47 (IC95%: 0,26-0,69), 0,67 (IC95%: 0,47-0,82) e 0,58 (IC95%: 0,43-0,72), respectivamente, enquanto a razão PGI/PGII mostrou sensibilidade, especificidade e acurácia de 0,06 (IC95%: 0,01-0,27), 0,83 (IC95%: 0,64-0,93) e 0,51 (IC95%: 0,36-0,66), respectivamente. CONCLUSÃO: As classificações histológicas OLGA e OLGIM apresentaram taxa de concordância substancial entre si. O uso simultâneo de ambos os sistemas de classificação histológica aumentou a taxa de identificação de pacientes de alto risco para desenvolvimento de câncer gástrico. Os resultados do GastroPanel® não foram eficazes para distinguir pacientes de baixo e alto risco para desenvolvimento de câncer gástrico na população estudada. Mais estudos são necessários para validar seu uso na prática clínica no Brasil.

ABSTRACT BACKGROUND: H. pylori chronic atrophic gastritis is a premalignant lesion, and its staging, according to OLGA and OLGIM systems aims to identify patients at increased risk of developing gastric cancer and optimize their follow-up. GastroPanel®, serum biomarkers panel including pepsinogen I (PGI), pepsinogen II (PGII), Gastrin 17 (G17) and anti- H. pylori antibodies is a noninvasive test for adenocarcinoma risk assessment in chronic H. pylori gastritis patients. OBJECTIVE: Prospective study to evaluate the concordance between OLGA and OLGIM grading systems, as well as to evaluate GastroPanel´s performance in patients with premalignant lesions secondary to H. pylori chronic gastritis in Brazil. METHODS: Patients with H. pylori chronic gastritis with premalignant lesions confirmed by histology were recruited from the gastrointestinal clinic of a University Hospital. All participants underwent endoscopic examination with biopsies which were reported according to updated Sydney system and premalignant lesions grading systems (OLGA and OLGIM). Blood samples were collected for biomarkers serological analysis (GastroPanel®, Biohit, Helsinki, Finland). The cut off values used to define high risk patients were those recommended by the manufacturer: PGI ≤30 µm/L and PGI/PGII ≤3. RESULTS: 41 patients were recruited: 28 women, 13 men, mean age 67.3 (47-89, SD: 9.6) years. By OLGA system, were obtained: OLGA 0 (n=1), OLGA I (n=7), OLGA II (n=17), OLGA III (n=9), and OLGA IV (n=7). By OLGIM system, were obtained: OLGIM 0 (n=14), OLGIM I (n=5), OLGIM II (n=10), OLGIM III (n=10), and OLGIM IV (n=2). Regarding histological staging among patients staged as low risk (OLGA/OLGIM 0, I and II) and high risk (OLGA/OLGIM III and IV) for gastric cancer development, the concordance rate found between both classifications was 85.4%. Considering high risk patients, those patients thus included in at least one of the systems the final distribution of our sample considered 24 low-risk and 17 high-risk patients for the development of gastric cancer. To determine by GastroPanel® whether the patient would be at low or high risk of developing gastric cancer, PGI showed a sensitivity, specificity and accuracy of 0.47 (95%CI: 0.26-0.69), 0.67 (95%CI: 0.47-0.82), and 0.58 (95%CI: 0.43-0.72), respectively, while PGI/PGII showed sensitivity, specificity and accuracy of 0.06 (95%CI: 0.01-0.27), 0.83 (95%CI: 0.64-0.93) and 0.51 (95%CI: 0.36-0.66), respectively. CONCLUSION: The histological classifications OLGA and OLGIM presented a substantial concordance rate among themselves. Simultaneous use of both histological classification systems increased the identification’s rate of high-risk patients. Biomarker analysis was not effective to distinguish low to high risk patients in the studied population. Further studies are needed to validate its use in clinical practice in Brazil.

ABSTRACT Aberrant expression of long non-coding RNAs (lncRNAs) has been detected in several types of cancer, including acute lymphoblastic leukemia (ALL), but lncRNA mapped on transcribed ultraconserved regions (T-UCRs) are little explored. The T-UCRs uc.112, uc.122, uc.160 and uc.262 were evaluated by quantitative real-time PCR in bone marrow samples from children with T-ALL (n = 32) and common-ALL/pre-B ALL (n = 30). In pediatric ALL, higher expression levels of uc.112 were found in patients with T-ALL, compared to patients with B-ALL. T-cells did not differ significantly from B-cells regarding uc.112 expression in non-tumor precursors from public data. Additionally, among B-ALL patients, uc.112 was also found to be increased in patients with hyperdiploidy, compared to other karyotype results. The uc.122, uc.160, and uc.262 were not associated with biological or clinical features. These findings suggest a potential role of uc.112 in pediatric ALL and emphasize the need for further investigation of T-UCR in pediatric ALL.

BACKGROUND During routine Coronavirus disease 2019 (COVID-19) diagnosis, an unusually high viral load was detected by reverse transcription real-time polymerase chain reaction (RT-qPCR) in a nasopharyngeal swab sample collected from a patient with respiratory and neurological symptoms who rapidly succumbed to the disease. Therefore we sought to characterise the infection. OBJECTIVES We aimed to determine and characterise the etiological agent responsible for the poor outcome. METHODS Classical virological methods, such as plaque assay and plaque reduction neutralisation test combined with amplicon-based sequencing, as well as a viral metagenomic approach, were performed to characterise the etiological agents of the infection. FINDINGS Plaque assay revealed two distinct plaque phenotypes, suggesting either the presence of two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains or a productive coinfection of two different species of virus. Amplicon-based sequencing did not support the presence of any SARS-CoV-2 genetic variants that would explain the high viral load and suggested the presence of a single SARS-CoV-2 strain. Nonetheless, the viral metagenomic analysis revealed that Coronaviridae and Herpesviridae were the predominant virus families within the sample. This finding was confirmed by a plaque reduction neutralisation test and PCR. MAIN CONCLUSIONS We characterised a productive coinfection of SARS-CoV-2 and Herpes simplex virus 1 (HSV-1) in a patient with severe symptoms that succumbed to the disease. Although we cannot establish the causal relationship between the coinfection and the severity of the clinical case, this work serves as a warning for future studies focused on the interplay between SARS-CoV-2 and HSV-1 coinfection and COVID-19 severity.

Resumo O laser de baixa potência provou ter sucesso em estimular a produção de colágeno em ensaios de cicatrização de feridas. Entretanto, grande diversidade tem sido observada nos protocolos utilizados. Este trabalho avaliou os efeitos de três protocolos de Terapia a Laser de Baixa Potência (TLBP) na cicatrização de feridas abertas em ratos. Feridas padronizadas com 1 cm2 de tamanho foram realizadas com um bisturi na região do dorso de 60 ratos Wistar machos pesando 225±25g, e foram divididos em quatro grupos (n=15): CTR (animais não irradiados), LT1 (20 J/cm2 diariamente), LT2 (16 J/cm2 diariamente) e LT3 (20 J/cm2 diariamente). Após 7, 14 e 21 dias, cinco animais/dia foram eutanasiados e as feridas analisadas histologicamente. Os dados foram submetidos à análise de normalidade da distribuição pelo teste de Shapiro-Wilk. Os dados gaussianos foram analisados pelos testes ANOVA e Bonferroni, enquanto que os dados não Gaussianos foram analisados pelos testes de Kruskal-Wallis e Dunn, considerando-se valores p significativos menores que 0,05. A TLBP em todos os protocolos reduziu a inflamação e aumentou significativamente a deposição de colágeno (p<0,05). Entretanto, LT2 apresentou os maiores níveis de colágeno em todas as fases do estudo (p<0,05), induzindo a substituição mais rápida do colágeno imaturo III pelo colágeno maduro I nos estágios iniciais de reparo e remodelação precoce do colágeno promovida por melhor organização dos feixes depositados. Concluiu-se que todos os protocolos induziram aumento da cicatriz de colágeno. Entretanto, o protocolo 2 (16 J/cm2, aplicação diária) promoveu os aumentos mais significativos na deposição de colágeno, acelerou a maturação do colágeno e apresentou a melhor arquitetura da cicatriz fibrosa final.

Abstract The low-level laser has proven successful in stimulating the production of collagen in wound healing assays. However, diversity has been observed in the protocols used. This work has evaluated the effects of three protocols of low-level laser therapy (LLLT) in the healing of open wounds in rats. Standard-sized wounds of 1 cm2 were performed with a scalpel in the middorsal region of 60 male Wistar rats weighing 225±25 g, and they were assigned into four groups (n=15): CTR (non-irradiated animals), LT1 (20 J/cm2 daily), LT2 (16 J/cm2 daily) and LT3 (20 J/cm2 daily). After 7, 14 and 21 days, five animals/day were euthanized and the wounds analyzed histologically. Data were subjected to normality analysis of distribution using Shapiro-Wilk test. Gaussian data were analyzed using ANOVA and Bonferroni tests whereas non-Gaussian data were analyzed using Kruskal-Wallis and Dunn tests, considering significant p values less than 0.05. The LLLT in all protocols reduced the inflammation and collagen deposition increased significantly (p<0.05). However, LT2 showed the highest levels of collagen in all phases of the study (p<0.05) induced faster replacement of immature collagen III by mature collagen I in the early stages of repair and early collagen remodeling promoted by providing better organization architectural beams deposited. It was concluded that all protocols induced an increase in collagen scar. However, the protocol 2 (16 J /cm2, daily application) promoted the most significant increases in collagen deposition, accelerated maturation of collagen and showed the best architecture of the final fibrous scarring.

RESUMO CONTEXTO: O teste respiratório com ureia-marcada com carbono-13 (TR-13C) é o método padrão-ouro para o diagnóstico não invasivo da infecção por H. pylori. Apesar disto, não existe uma uniformização de protocolos para a sua realização, trazendo dificuldades operacionais para laboratórios ou clínicas que operam com equipamentos de fabricantes diferentes. OBJETIVO: Estudo prospectivo e comparativo para validação do TR-13C para o diagnóstico de infecção por H. pylori, com emprego de protocolo único para dois equipamentos diferentes, a saber: BreathID Hp Lab System® (Exalenz Bioscience Ltd, Israel), aqui denominado equipamento A e IRIS-Doc2® (Wagner Analysen-Technik, Alemanha, agora Mayoly Spindler Group, França), aqui denominado equipamento B. MÉTODOS: Um total de 518 pacientes (365 mulheres e 153 homens, idade média de 53 anos) consecutivamente encaminhados para a realização do TR-13C foram incluídos no estudo. Todos os participantes realizaram TR-13C, que foi processado e analisado simultaneamente pelos dois equipamentos. Embora os dois equipamentos possuam protocolos independentes previamente validados, foi optado, por sua maior praticidade, pela utilização de um único protocolo, conforme recomendado pelo fabricante do equipamento A, e assim resumido: após jejum mínimo de 1h, foram amostras de ar expirado coletadas em dois pequenos sacos coletores (120 mL), correspondendo ao tempo-zero (amostra-1, controle). Em seguida, os pacientes ingeriram, em até 2 min, uma solução aquosa (200 mL) contendo 75 mg de 13C-ureia e 4,0 gramas de ácido cítrico em pó, adicionado com edulcorante. Uma segunda coleta de ar expirado era realizada 15 min após a ingestão do substrato em dois novos pequenos sacos coletores, correspondendo à amostra-2. Foram considerados positivos para a presença da infecção por H. pylori quando apresentavam um delta over baseline (DOB) igual ou maior que 5‰. Análise estatística foi realizada com o teste de Wilcoxon, coeficiente kappa com IC 95% e método de Wilson. RESULTADOS: Considerando o protocolo do equipamento A como o padrão-ouro, sua comparação com o equipamento B mostrou sensibilidade de 99,3% (IC 95%: 96,3-99,9) e especificidade de 98,9% (IC 95%: 97,3-99,6). O coeficiente kappa observado foi de 0,976 (IC 95%: 0,956-0,997). CONCLUSÃO: A correlação entre os dois equipamentos foi excelente e contribui para uma uniformização de protocolos para TR-13C.

ABSTRACT BACKGROUND: 13C-urea breath test (UBT) is the gold-standard, noninvasive method for H. pylori diagnosis. However, there is no uniform standardization of the test. This situation can be unpractical for laboratories running with two or more devices. OBJECTIVE: To perform a prospective comparison validation study of UBT employing one validated protocol for two different devices: BreathID Hp Lab System® (Exalenz Bioscience Ltd, Israel), here called device A and IRIS-Doc2® (Wagner Analysen-Technik, Germany, now Mayoly Spindler Group, France), here called device B, in the diagnosis of H. pylori infection. METHODS: A total of 518 consecutive patients (365 females, 153 males, mean age 53 years) referred for UBT were included. All patients received device A protocol as follow: after at least one hour fasting, patients filled two bags prior to the test, then ingested an aqueous solution containing 75 mg of 13C-urea with a 4.0 g citric acid powder and filled another two bags 15 min after ingesting the test solution. One pair of breath sample bags (before and after ingestion) was analyzed by the two different devices. A delta over baseline (DOB) ≥5‰ indicated H. pylori infection. Statistics: Wilcoxon test, kappa coefficient with 95% CI, Wilson’s method. RESULTS: Considering the device A protocol as the gold standard, its comparison with device B showed a sensitivity of 99.3% (95% CI: 96.3-99.9) and a specificity of 98.9% (95% CI: 97.3-99.6). Kappa coefficient was 0.976 (95% IC: 0.956-0.997). CONCLUSION: Correlation between the two devices was excellent and supports a uniform standardization of UBT.

RESUMO Objetivo O objetivo deste estudo foi avaliar a ingestão de nutrientes antioxidantes por gestantes atendidas em rede pública de saúde e os fatores associados. Métodos Trata-se de estudo transversal com gestantes atendidas na rede pública de saúde do município de Maceió no ano de 2014, sendo incluídas 385 gestantes e seus recém-nascidos. Foram coletadas informações acerca das mães (dados socioeconômicos, pessoais, de pré-natal, dietéticos e antropométricos) e, após o parto, dos recém-nascidos (idade gestacional, peso e comprimento ao nascer). A ingestão alimentar foi avaliada por dois recordatórios alimentares de 24h, relatados pela gestante, com posteriores ajustes pelo método Estimativa de Requerimento Médio. Os dados foram processados, sendo utilizada a correlação de Pearson para avaliar associações, com p<0,05 como significativo. Resultados Foram estudadas 388 gestantes, com média de idade de 24,06±5,92 anos, com ingestão inadequada e alta variação da ingestão dos antioxidantes: Vitamina A (83,2%/62,7%), Vitamina C (50,5%/75,7%), Vitamina E (76,5%/60,2%), Selênio (60,8%/ 50,3%), Cobre (98,5%/42,8%) e Zinco (79,6%/43,4%), respectivamente. Adicionalmente, foi observada associação entre a ingestão de vitamina A (p=0,02), Cobre (p=0,01) e Selênio (p=0,01), e o Índice de Massa Corporal materno. Observou-se também associação entre a ingestão de vitamina A (0,04) e selênio (p=0,02) e o peso ao nascer; e de vitamina A (p=0,04) com comprimento ao nascer. Conclusão A baixa ingestão de nutrientes antioxidantes por gestantes é uma realidade, estando associada ao Índice de Massa Corporal materno e ao peso e comprimento do recém-nascido ao nascer.

ABSTRACT Objective To evaluate the intake of antioxidant nutrients by pregnant women being cared for in the Brazilian public health system and associated factors. Methods A cross-sectional study was carried out with pregnant women cared for in the public health system in the city of Maceió, Brazil, in 2014, including 385 pregnant women and their newborns, and the collection of maternal information (socioeconomic, personal, prenatal, dietary and anthropometric data), and after the babies’ birth (gestational age, birth weight and length). Food intake was assessed by two 24-hour dietary reminders per pregnant woman with subsequent adjustments by the Estimated Average Requirement method. Data were processed and Pearson’s correlation was used to evaluate associations, considering p<0.05 as significant. Results A total of 388 pregnant women with a mean age of 24.06±5.92 years were studied, with inadequate intake and high variation of the following antioxidants: vitamin A (83.2%/62.7%), vitamin C (50.5%/75.7%), vitamin E (76.5%/60.2%), Selenium (60.8%/50.3%), Copper (98.5%/42.8%) and Zinc (79.6%/43.4%), respectively. Additionally, the following associations were observed: the intake of vitamin A (p=0.02), Copper (p=0.01), and Selenium (p=0.01) with the maternal Body Mass Index; the intake of vitamin A (0.04) and Selenium (p=0.02) with the birth weight; and between vitamin A (p=0.04) with the birth length. Conclusion The low intake of antioxidant nutrients by pregnant women is a reality, being associated to the maternal Body Mass Index and the birth weight and length of the newborn.

RESUMO Os avanços significativos ocorridos desde o III Consenso Brasileiro sobre H. pylori realizado em 2012, em Bento Gonçalves, justificam este quarto consenso. O evento foi organizado pelo Núcleo Brasileiro para Estudo do Helicobacter e Microbiota, associação vinculada à Federação Brasileira de Gastroenterologia, tendo sido realizado novamente em Bento Gonçalves, RS, nos dias 25 a 27 de agosto de 2017. Participaram 26 delegados provenientes das cinco regiões brasileiras incluindo gastroenterologistas, endoscopistas e patologistas, além de um convidado internacional (EUA). Os participantes foram convidados pelo conhecimento e contribuição ao estudo da infecção por H. pylori. O encontro buscou rever diferentes aspectos relacionados ao tratamento da infecção, suas inter-relações com a dispepsia, microbiota e outras afecções, com ênfase especial ao câncer gástrico, além de promover uma reavaliação dos aspectos epidemiológicos e diagnósticos desta infecção. Os participantes foram alocados em quatro grupos, a saber: 1) Epidemiologia e diagnóstico, 2) Dispepsia, microbiota e outras afecções, 3) Neoplasias gástricas, e 4) Tratamento. Previamente à reunião do Consenso, os participantes receberam um tema a ser discutido e elaboraram texto com uma revisão recente da literatura, contendo uma assertiva de sua revisão. Todas as assertivas foram avaliadas em dois turnos de votação. Inicialmente, cada participante apresentava sua compilação e assertiva ao seu grupo, para eventuais modificações e votação. Posteriormente, em uma segunda votação, agora em sessão plenária, as assertivas eram novamente votadas e eventualmente modificadas. As votações obedeceram a cinco alternativas: 1) concorda fortemente; 2) concorda com reservas; 3) indeciso; 4) discorda e; 5) discorda fortemente. O índice de consenso adotado para cada afirmativa foi de 80% dos votantes respondendo que concorda fortemente ou concorda com reservas. As recomendações aqui apresentadas foram baseadas nas evidências científicas mais relevantes para o manuseio da infecção por H. pylori na população adulta no Brasil.

ABSTRACT Significant progress has been obtained since the III Brazilian Consensus Conference on H. pylori infection held in 2012, in Bento Gonçalves, Brazil, and justify a fourth meeting to establish updated guidelines on the current management of H. pylori infection. Therefore, the Núcleo Brasileiro para Estudo do Helicobacter pylori e Microbiota (NBEHPM), association linked to Brazilian Federation of Gastroenterology (FBG) held its fourth meeting again in Bento Gonçalves, RS, Brazil, on August 25-27, 2017. Twenty-six delegates, including gastroenterologists, endoscopists, and pathologists from the five regions of Brazil as well as one international guest from the United States, participated in the meeting. The participants were invited based on their knowledge and contribution to the study of H. pylori infection. The meeting sought to review different aspects of treatment for infection; establish a correlation between infection, dyspepsia, intestinal microbiota changes, and other disorders with a special emphasis on gastric cancer; and reassess the epidemiological and diagnostic aspects of H. pylori infection. Participants were allocated into four groups as follows: 1) Epidemiology and Diagnosis, 2) Dyspepsia, intestinal microbiota and other afections, 3) Gastric Cancer, and, 4) Treatment. Before the consensus meeting, participants received a topic to be discussed and prepared a document containing a recent literature review and statements that should be discussed and eventually modified during the face-to-face meeting. All statements were evaluated in two rounds of voting. Initially, each participant discussed the document and statements with his group for possible modifications and voting. Subsequently, during a second voting in a plenary session in the presence of all participants, the statements were voted upon and eventually modified. The participants could vote using five alternatives: 1) strongly agree; 2) partially agree; 3) undecided; 4) disagree; and 5) strongly disagree. The adopted consensus index was that 80% of the participants responded that they strongly or partially agreed with each statement. The recommendations reported are intended to provide the most current and relevant evidences to management of H. pylori infection in adult population in Brazil.

ABSTRACT: Cranioencephalic trauma (CET) is defined is the combination of neural and vascular injuries and their inflammatory effects in the brain, skull and scalp. This modality of trauma may lead to motor, psychological and cognitive sequels or even death. The present study aimed to assess the main epidemiological aspects in victims of CET treated at Cuiabá Municipal Hospital (CMH), Brazil. An observational and analytical study was performed in the medical records of patients diagnosed with CET treated at CMH between July and December of 2000, 2006 and 2011. The information retrieved from the patients consisted of age, sex, place of residence, cause of trauma, association with other trauma, outcomes (death or discharge) and the severity of neurological effect (Glasgow Coma Scale). The data obtained was analyzed descriptively with absolute (n) and relative (%) quantification. Medical records of 669 victims were analyzed, out of which 567 were males (84.7 %). Male patients were aged between 20 and 39 years old (mean age: 32.8 years). The most prevalent cause of trauma was the motorcycle accident (26.6 %). The neurological severity of the CET was mild in most of the cases (32.5 %). Considering the place of residence, most of the patients (n=331; 49.5 %) were from the capital city of Mato Grosso State (Cuiabá, Brazil). Four-hundred seventy-nine (71.6 %) patients progressed without death. A high prevalence rate of CET was observed at CMH. Major attention must be given to young adult victims of motorcycle accidents.

RESUMEN: El traumatismo craneoencefálico (TCE) se define como una combinación de daño neural, insuficiencia vascular y efectos inflamatorios que comprometen el cráneo, el encéfalo y el cuero cabelludo, causando la muerte, o serias secuelas motoras, psicológicas y cognitivas. De esta forma, el objetivo de este trabajo fue evaluar los principales aspectos epidemiológicos en victimas de Traumatismo Craneoencefálico (TCE) atendidas en el Hospital y Sala de Primeros Auxilios Municipal de Cuiabá (HPSMC), Brasil. Se trata de un estudio observacional de historias clínicas del archivo del HPSMC, admitidos con diagnóstico de TCE en el período de julio a diciembre de los años 2000, 2006 y 2011. Se consideraron el rango de edad, el sexo, la procedencia de las víctimas, la causa del trauma, la asociación con otros traumas, la defunción y el alta, el cuadro neurológico (Escala de Coma de Glasgow - ECG). El análisis de los datos fue descriptivo con números absolutos y porcentajes. Se evaluaron historias clínicas de 669 víctimas de TCE, en los que el sexo masculino fue el de mayor prevalencia con 567 casos (84,7 %), con mayor incidencia en el rango de edad de 20 a 39 años (39,2 %), el promedio de edad fue de 32,8 años, siendo la etiología más frecuente los accidentes motociclísticos (26,6 %). En el momento de la admisión de acuerdo al ECG hubo una predominancia de TCE leve (32,5 %). En cuanto a la procedencia, 331 (49,5 %) eran del municipio de Cuiabá. Del total de víctimas, 479 (71,6 %) evolucionaron hasta tener el alta hospitalaria. Se registró una prevalencia elevada de TCE en el HPSMC, con predominancia de víctimas adultas jóvenes de sexo masculino, siendo los accidentes motociclísticos la principal causa.

RESUMO Objetivo: Avaliar as atitudes dos alunos internos de um curso de Medicina a respeito da relação médico-paciente, tendo como dimensões desta relação o cuidar e o compartilhar. Métodos: Trata-se de um estudo transversal descritivo com abordagem quantitativa. No desenvolvimento da pesquisa foi utilizado um questionário com dados sociodemográficos ocupacionais e a Patient-Practitioner Orientation Scale (PPOS), que avalia a relação médico-paciente na perspectiva de estudantes. Foram entrevistados 136 alunos internos de um curso de Medicina de uma universidade de Goiânia (GO). Resultados: A média de idade dos alunos internos pesquisados foi de 24,7 (± 2,8), sendo 90 do sexo feminino (66,7%) e 128 (94,1%) solteiros. Os escores entre todos os alunos internos foram: global (4,48 ± 1,56), compartilhar (3,92 ± 1,59) e cuidar (5,04 ± 1,31). As mulheres apresentaram escores maiores no que tange ao fator “compartilhar” (3,97 ± 11,61) em relação aos homens (3,82 ± 1,54), com p = 0,034, e também na média global, feminino (4,51 ± 1,57) e masculino (4,40 ± 1,55), com p = 0,047. No fator “compartilhar”, aqueles que afirmaram ter realizado estágio extracurricular (3,98 ± 1,62) tiveram melhor escore do que os que não fizeram (3,81 ± 1,53), com p = 0,033. Os estudantes que apontaram a contribuição social na escolha do curso de Medicina (4,00 ± 1,58) apresentaram melhor escore no fator “compartilhar”. Conclusão: A maioria dos alunos internos pesquisados teve a atenção voltada à figura do médico e não à do paciente, o que é demonstrado principalmente pelo decréscimo dos escores no final dos períodos de formação. Em contrapartida, os acadêmicos acreditam que as expectativas, sentimentos e circunstâncias da vida do paciente possam interferir no tratamento. Mulheres, alunos que realizaram atividades extracurriculares durante o curso e estudantes que apontaram a contribuição social na escolha do curso apresentaram melhores resultados sob o ponto de vista de dialogar e permitir que o paciente faça parte do tratamento.

ABSTRACT Objective: To evaluate the attitudes of the medical intern students regarding the doctor-patient relationship, in terms of the aspects of caring and sharing. Methods: This is a cross-sectional descriptive study with a quantitative approach. Two questionnaires were used in the development of the study, one with occupational sociodemographic data and the other the Patient-Practitioner Orientation Scale (PPOS), which aims to evaluate the doctor-patient relationship from the student's perspective. A total of 136 medical intern students from a university in Goiânia/GO were interviewed. Results: the mean age of the sample population was 24.7 (± 2.8), 90 were female (66.7%) and 128 (94.1%) were single. Among all the students the scores were: overall (4.48 ± 1.56), sharing (3.92 ± 1.59) and caring (5.04 ± 1.31). The women presented higher scores in the “sharing” aspect (3.97 ± 11.61) than the men (3.82 ± 1.54), with p = 0.034, and in the global mean, female (4.51 ± 1, 57) and male (4.40 ± 1.55), with p = 0.047. For the “sharing” factor, those who said they had completed extracurricular internship (3.98 ± 1.62) reported a better score than those who had not (3.81 ± 1.53), with p = 0.033. The students that specified social contribution as a factor in their decision to follow the medical course (4.00 ± 1.58) presented a better score in the “sharing” factor. Conclusion: Most of the intern students focused their attention on the doctor figure rather than the patient, especially with the lower scores at the end of the training period. By contrast, the academics believed that the patient's expectations, feelings, and life circumstances may interfere with their treatment. Women, students who performed extracurricular activities during the course and students who pointed out social contribution as a factor in their decision to follow a medical career, presented better results from the point of view of dialogue and allowing the patient to be part of the treatment.