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ABSTRACT OBJECTIVE To evaluate the quality of information on gestational syphilis (GS) and congenital syphilis (CS) on the Sistema de Informação de Agravos de Notificação (SINAN-Syphilis Brazil – Notifiable Diseases Information System) by compiling and validating completeness indicators between 2007 and 2018. METHODS Overall, care, and socioeconomic completeness scores were compiled based on selected variables, by using ad hoc weights assigned by experts. The completeness scores were analysed, considering the region and area of residence, the pregnant woman’s race/colour, and the year of case notification. Pearson’s correlation coefficients were used to validate the scores obtained by the weighted average method, compared with the values obtained by principal component analysis (PCA). RESULTS Most selected variables presented a good or excellent degree of completeness for GS and CS, except for clinical classification, pregnant woman’s level of education, partner’s treatment, and child’s race/colour, which were classified as poor or very poor. The overall (89.93% versus 89.69%) and socioeconomic (88.71% versus 88.24%) completeness scores for GS and CS, respectively, were classified as regular, whereas the care score (GS-90.88%, and CS-90.72%) was good, despite improvements over time. Differences in the overall, care and socioeconomic completeness scores according to region, area of residence, and ethnic-racial groups were reported for syphilis notifications. The completeness scores estimated by the weighted average method and PCA showed a strong linear correlation (> 0.90). CONCLUSION The completeness of GS and CS notifications has been improving in recent years, highlighting the variables that form the care score, compared with the socioeconomic scores, despite differences between regions, area of residence, and ethnic-racial groups. The weighted average was a viable methodological alternative easily operationalised to estimate data completeness scores, allowing routine monitoring of the completeness of gestational and congenital syphilis records.

https://doi.org/10.11606/s1518-8787.2023057004789

How many species of Mollusca are there in Brazil? A collective taxonomic effort to reveal this still unknown diversity
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Machado, Fabrizio M.

; Miranda, Marcel S.

; Salvador, Rodrigo B.

; Pimenta, Alexandre D.

; Côrtes, Mariana O.

; Gomes, Jaime A.J.

; Miyahira, Igor C.

; Agudo-Padrón, Ignacio

; Oliveira, Cléo D.C.

; Caetano, Carlos H.S.

; Coelho, Paulo R.S.

; D’Ávila, Sthefane

; Arruda, Eliane P. de

; Almeida, Sérgio M. de

; Gomes, Suzete R.

; Alvim, Juliana

; Galvão-Filho, Hilton

; L. Ferreira-Júnior, Augusto

; Marques, Rodrigo C.

; Martins, Inês

; Souza, Leonardo S. de

; Arruda, Janine O.

; Cavallari, Daniel C.

; Santos, Sonia B. dos

; Pedro, Natan C.

; Salles, Anna C. de A.

; Dornellas, Ana P.S.

; Lima, Tarcilla C. de

; Amaral, Vanessa S. do

; Silva, Fernanda S.

; Passos, Flávio D.

; Thiengo, Silvana S.

; Leite, Tatiana S.

; Simone, Luiz R.L.

Zoologia (Curitiba)

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2023, Volumen 40 elocation e23026

Resumen: En | Texto: En | PDF: En

ABSTRACT The expression ‘you need to know to conserve’ is a well-known cliche among biologists. Documenting the richness of a group of organisms is the first step towards understanding biodiversity and preparing efficient conservation plans. In this context, many efforts have been made to quantify the number of species on Earth and estimate the number of species still unknown to science. A few countries have complete and integrated databases estimating the approximate number of species recorded for their territory, particularly in the Global South. In Brazil, a country of continental dimensions, revealing the richness of the second most diverse clade of invertebrates (=Mollusca) has been a goal of taxonomists. Recently, in an unprecedented, collective, and integrated effort among Brazilian malacologists, it was possible to estimate how many valid species of molluscs are there in Brazil. In this effort, more than 30 mollusc experts joined together to update the Taxonomic Catalogue of the Brazilian Fauna (TCBF), a governmental website that allows a quick and real-time updating of all Metazoan. So far, more than 5,000 updates have been made in TCBF, indicating the presence of 3,552 valid species of molluscs in Brazil, distributed among the main clades as follows: Caudofoveata (10 spp.), Solenogastres (6 spp.), Polyplacophora (35 spp.), Scaphopoda (43 spp.), Cephalopoda (92 spp.), Bivalvia (629 spp.) and Gastropoda (2,737 spp.). The present study, in addition to demonstrating for the first time the richness of Brazilian molluscs, also presents the state of the art of this important phylum of invertebrates highlighting its most representative and neglected groups.

https://doi.org/10.1590/s1984-4689.v40.e23026

The Challenges of Implementing a Text Message Intervention to Promote Behavioral Change in Primary Care Patients With Hypertension and Diabetes
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Oliveira, João Antonio de Queiroz

; Cimini, Christiane

; Almeida, Vania

; Maia, Junia Xavier

; Resende, Raissa Eda

; Gualberto, Leticia Alves

; Santos, Pedro Henrique Lauar

; Gomes, Paulo R.

; Bonisson, Leonardo

; Paixão, Maria Cristina

; Costa, Janaina Moutinho

; Cardoso, Clareci Silva

; Santo, Karla

; Ribeiro, Antonio

; Martins, Maria Auxiliadora

; Marcolino, Milena S.

International Journal of Cardiovascular Sciences

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2023, Volumen 36 elocation e20220050

Resumen: En | Texto: En | PDF: En

Abstract Background Controlling blood pressure and glycemic levels is a challenge that requires innovative solutions. Objective To assess the feasibility of implementing a text message intervention among low-income primary care patients, as well as to assess self-reported behavioral change. Methods A set of 200 text messages was developed on healthy eating, physical activity, adherence, and motivation. Participants from Vale do Mucuri, MG, Brazil diagnosed with diabetes or hypertension or undergoing screening for those diseases, received 5 to 8 messages per week for 6 months. They answered a questionnaire to report their satisfaction and behavioral changes. Results Of the 136 patients, 117 (86.0%) answered the questionnaire. Most reported that the messages were very useful (86.3%), easy to understand (90.6%), and were very helpful for behavioral change (65.0%); 84.6% reported that they had started eating healthier. The most frequent reported lifestyle changes were: improved diet quality (85.5%), reduced portions (65.8%), and weight loss (56.4%). The majority of patients shared the messages (60.7%) with family or other acquaintances, considered the number of messages to be adequate (89.7%) and would recommend the program to others (95.7%). Conclusion An intervention based on text messages to promote behavioral change in patients with hypertension or diabetes in primary care is feasible in low-resource settings. Future studies are needed to assess the program’s long-term effects on clinical outcomes.

https://doi.org/10.36660/ijcs.20220050

EMISSIONS AND PERFORMANCE OF A DIESEL ENGINE AFFECTED BY CRAMBE BIODIESEL BLENDS
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Reis, Leonardo da S.

; Santos, Reginaldo F.

; Lewandoski, Cristiano F.

; Silva, Evelyn T. C.

; Oliveira, Wilson A. de

Engenharia Agrícola

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2023, Volumen 43 Nº spe elocation e20220113

Resumen: En | Texto: En | PDF: En

ABSTRACT Brazil has been facing a huge rise in fuel and diesel prices due to the rise in the international market and the war between Ukraine and Russia. The rise in electricity prices is also a problem that affects everyone in Brazil. This study aimed to evaluate the performance and emissions of a diesel engine for power generation that operates with crambe-based fuels with blends of 0% (control), B5, B10, B15, B20, B50, B70, and B90. The fuels were tested in an 8 kVA generator engine at a load of up to 6000 W. The biofuels were obtained from a mixture of diesel with crambe biodiesel at incremental levels from B0 to B90 in the fuel mixture. The increased proportion of crambe biodiesel resulted in lower specific consumption. Crambe biodiesel resulted in a reduction of CO, CO2, and NO2 emissions due to an increase in crambe biodiesel at the proportion. The results indicate that crambe biodiesel blends are viable technical solutions for the partial replacement of conventional diesel.

https://doi.org/10.1590/1809-4430-eng.agric.v43nepe20220113/2023

Fast and Green Hematite (α-Fe2O3) and Akaganeite (β-FeOOH) Synthesis Using a Microwave-Assisted Hydrothermal Process with Single Precursor and No Stabilizing Agent
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Diniz, Paulo Afonso F.

; Cavalcante, Kiany Sirley B.

; Souza, Josiane Carneiro

; Marques, Gleison N.

; Santos, Fernanda Hellen de S.

; Cutrim, Fiama M.

; Henriques, Raelma B.

; Mendonça, Leonardo T. B.

; Nascimento, Ulisses M.

Materials Research

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2023, Volumen 26 elocation e20230016

Resumen: En | Texto: En | PDF: En

In this work, iron chloride (FeCl3.6H2O), a single reagent, was used to create the phases of hematite (α-Fe2O3) and akaganeite (β-FeOOH) without the need of organic solvents using the microwave-assisted hydrothermal technique (HM). X-ray diffraction demonstrated the efficacy of the HM technique in the generation of crystalline phases of α-Fe2O3 at 180oC and β-FeOOH at 120oC. The development of pseudo-cunic and stick-like particles was a result of changes in experimental variables, which also had a substantial impact on the materials structural characteristics. The nitrogen (N2) adsorption/desorption isotherms of the samples containing akaganeite and hematite phase resembled those of mesoporous materials. Hematite has a surface area of 25.44 m2 g-1, while akaganeite has a surface area of 110.60 m2 g-1, according to the calculation. Thermodifferential and thermogravimetric techniques were used to assess thermal degradation. The use of microwave hydrothermal synthesis was promoted as being quick, easy, affordable, and safe for the environment.

https://doi.org/10.1590/1980-5373-mr-2023-0016

Acai Residue as an Ecologic Filler to Reinforcement of Natural Rubber Biocomposites
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Araújo, Samara S.

; Santos, Gleyson T. A.

; Tolosa, Gabrieli R.

; Hiranobe, Carlos T.

; Budemberg, Eduardo R.

; Cabrera, Flávio C.

; Silva, Michael J. da

; Paim, Leonardo L.

; Job, Aldo E.

; Santos, Renivaldo J. dos

Materials Research

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2023, Volumen 26 Supl. 1 elocation e20220505

Resumen: En | Texto: En | PDF: En

The biodiversity of plant resources is a renewable source that can use as a sustainable component in various applications. The use of vegetable waste as a filler element in polymeric composites is part of the solid waste management policy and the sustainable development of agribusiness. In this work, the natural rubber composites were prepared with acai seed in proportions of 0, 10, 20, 30, 40, and 50 phr (per hundred rubber). The composites were homogenized in an open cylinder mixer and characterized by rheometric, morphological, mechanical, and thermal tests. The addition of the organic fillers significantly reduced the vulcanization process time. Thermogravimetric analysis and infrared spectroscopy showed that the composites were thermally stable and showed no structure changes after the vulcanization process, respectively. The Lorenz-Parks method's evaluation of matrix/filler interactions showed a strong interaction between NR/Acai. The new biocomposite can replace non-ecological composites economically and sustainably.

https://doi.org/10.1590/1980-5373-mr-2022-0505

A completeness indicator of gestational and congenital syphilis information in Brazil
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Oliveira, Guilherme Lopes de

; Ferreira, Andrêa JF

; Santana, José Guilherme

; Lana, Raquel Martins

; Cardoso, Andrey Moreira

; Teles, Carlos

; Fiaccone, Rosemeire L.

; Aquino, Rosana

; Soares, Maria Auxiliadora Santos

; Paixao, Enny S.

; Santos, Idália Oliveira

; Salvi, Leonardo

; Barreto, Maurício L.

; Ichihara, Maria Yury

Revista de Saúde Pública

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2023, Volumen 57 elocation 42

Resumen: En | Texto: En | PDF: En

https://doi.org/10.11606/s1518-8787.2023057004789

Superabsorbent biodegradable CMC membranes loaded with propolis: Peppas-Sahlin kinetics release
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Sousa, Juliana Paes Leme de Mello

; Oliveira, Renata Nunes

; Santos, Antonia Monica Neres

; Gamallo, Ormindo Domingues

; Araújo, Leonardo Sales

; Middea, Antonieta

; Cid, Yara Peluso

; Castro, Rosane Nora

Polímeros

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2023, Volumen 33 Nº 2 elocation e20230010

Resumen: En | Texto: En | PDF: En

Abstract Propolis is a resinous product collected by honeybees with a complex chemical composition. Sodium carboxymethylcellulose is a polymer commonly used in wound care. The goal of the present work was to produce and characterize NaCMC membranes loaded with extract of Brazilian brown propolis (CMC-P). Flavonoids and phenolic acids were identified in the propolis extracts, where the main identified substance was kaempferide. The brown propolis extracted was active against S. aureus. The low swelling capacity and high gel fraction of CMC-P would be the consequence of propolis (responsible for a hydrophobic barrier) filling the pores of the membrane. Propolis could be anchoring the NaCMC chains (as observed by FTIR) due to interaction between components, which is corroborated by the CMC-P sample degrading less than the CMC sample (>400ºC). There was non-linear diffusion release kinetics for most phenolic substances of the propolis extract. The CMC-P sample presents potential as a dressing material.

https://doi.org/10.1590/0104-1428.20230010

Antibacterial Profile in vitro and in vivo of New 1,4-Naphthoquinones Tethered to 1,2,3-1H-Triazoles Against the Planktonic Growth of Streptococcus mutans
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Gomes, Mônica P.

; Correia, Eduardo M.

; Gomes, Max W. L.

; Santos, Claudio C. C. dos

; Barros, Caroline S.

; Abreu, Fernanda V. de

; Antunes, Leonardo S.

; Ferreira, Vitor F.

; Gonçalves, Mariana C.

; Resende, Gabriel O. de

; Gonzaga, Daniel T. G.

; Pinto, Carla E. C.

; Paixão, Izabel C. N. P.

; Silva, Fernando C. da

Journal of the Brazilian Chemical Society

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Sep 2022, Volumen 33 Nº 9 Paginas 1028 - 1040

Resumen: En | Texto: En | PDF: En

The cariogenic processes are mainly caused by the bacterium Streptococcus mutans (S. mutans) and consist of the demineralization of the tooth that occurs when the acid production overcomes the natural repair or if a problem occurs in the last one. In this work, we performed the synthesis of twenty-one 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles (8a-8k and 9a-9j), antibacterial evaluation against the S. mutans in vitro and the acute toxicity of the better ones in vivo. We observed strong inhibition results in the disc diffusion test ranging, the halos of inhibitions, from 18.66 (± 0.57) to 29 (± 2.64) mm, and good values in the minimum inhibitory concentration (5 to 50 μg), for the compounds 9e, 9h, 9i and 9j: Furthermore, they do not have a cytotoxic effect at the concentrations tested. Besides that, in the in vivo test, they show some slight alteration in the histopathological analyses and the biochemistry. Thus, we found four potential candidates to become instruments for the treatment of cavities.

https://doi.org/10.21577/0103-5053.20220014

10.

Latin American Consensus on management of residual cardiometabolic risk. A consensus paper prepared by the Latin American Academy for the Study of Lipids and Cardiometabolic Risk (ALALIP) endorsed by the Inter-American Society of Cardiology (IASC), the International Atherosclerosis Society (IAS), and the Pan-American College of Endothelium (PACE)
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Ponte-Negretti, Carlos I.

; Wyss, Fernando S.

; Piskorz, Daniel

; Santos, Raul D

; Villar, Raul

; Lorenzatti, Alberto

; López-Jaramillo, Patricio

; Toth, Peter P.

; Amaro, A. Juan J.

; Rodrigo, Alfonso K.

; Lanas, Fernando

; Urina-Triana, Miguel

; Lara, Jofre

; Valdés, T. Osiris

; Gomez-Mancebo, José R.

; Bryce, Alfonso

; Cobos S., Leonardo

; Puente-Barragan, Adriana

; Ullauri-Solórzano, Vladimir E.

; Medina-Palomino, Felix A.

; Lozada, Alfredo F.

; Duran, Maritza

; Berrospi, Percy

; Miranda, David

; Badimon, Juan J.

; González, J. José R.

; Libby, Peter

Archivos de cardiología de México

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Mar 2022, Volumen 92 Nº 1 Paginas 99 - 112

Resumen: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Background: Hypertension, hyperglycemia, dyslipidemia, overweight, obesity, and tobacco (smoking, chewing, and vaping), together with a pro-inflammatory and procoagulant state, are the main risk factors related to atherosclerotic cardiovascular disease. Objective and methods: A group of experts from the Americas, based on their clinical expertise in cardiology, cardiovascular prevention, and cardiometabolic (CM) diseases, joined together to develop these practical recommendations for the optimal evaluation and treatment of residual CM risk factors in Latin America, using a modified Delphi methodology (details in electronic TSI) to generate a comprehensive CM risk reduction guideline, and through personalized medicine and patient-centered decision, considering the cost-benefit ratio The process was well defined to avoid conflicts of interest that could bias the discussion and recommendations. Results: Residual risk reduction should consider therapeutic options adapted to specific patient needs, based on five treatment objectives: triglyceride-rich lipoproteins, inflammation, impaired glucose metabolism, high blood pressure, and prothrombotic status. Comprehensive control of all CM risk factors should be a priority to deal with this important public health problem and prevent premature deaths. The recommendations in this paper address the evidence-based treatment of CM risk and are intended for clinical application in Latin American countries.

Resumen Antecedentes: Un grupo de factores de riesgo cardiometabólicos (hipertensión, hiperglucemia, dislipidemia, sobrepeso, obesidad y tabaco (fumado, masticado, vaporizado), junto con un estado proinflamatorio y procoagulante, son los principales factores de riesgo relacionados con la enfermedad cardiovascular aterosclerótica. Objetivo y métodos: Basándose en su experiencia en cardiología, prevención cardiovascular y enfermedades cardiometabólicas, un grupo de expertos de las Américas se unió para desarrollar estas recomendaciones prácticas para la evaluación y tratamiento óptimos de los factores de riesgo cardiometabólicos residuales en América Latina, utilizando una metodología Delphi modificada con el objetivo de generar una guía integral de pautas para la reducción del riesgo cardiometabólico, mediante la medicina personalizada y la decisión centrada en el paciente teniendo en cuenta la relación costo-beneficio. El proceso fue bien definido para evitar conflictos de intereses que podrían sesgar la discusión y las recomendaciones. Resultados: La reducción del riesgo residual debe considerar opciones terapéuticas adaptadas a las necesidades específicas del paciente, basadas en 5 objetivos de tratamiento: lipoproteínas ricas en triglicéridos inflamación, metabolismo de la glucosa, presión arterial alta y estado protrombótico. El Control integral de todos los factores de riesgo cardiometabólicos debe ser una prioridad para hacer frente a este importante problema de salud pública y prevenir las muertes prematuras. Las recomendaciones de este documento abordan el tratamiento basado en evidencia del riesgo cardiometabólico y están destinadas a la aplicación clínica en los países de América Latina.

https://doi.org/10.24875/acm.21000005 55 descargas

11.

Lagged response of Tropical Atlantic Ocean to cold and fresh water pulse from Antarctic sea ice melting
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TORRES, ANA LAURA R.

; PARISE, CLAUDIA K.

; PEZZI, LUCIANO P.

; QUEIROZ, MICHELLY G. DOS SANTOS

; MACHADO, ADILSON M.B.

; CERVEIRA, GABRIEL S.

; CORREIA, GUSTAVO S.

; BARBOSA, WESLEY L.

; LIMA, LEONARDO G. DE

; SUTIL, UESLEI A.

Anais da Academia Brasileira de Ciências

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2022, Volumen 94 Supl. 1 elocation e20210800

Resumen: En | Texto: En | PDF: En

Abstract The formation of dense water masses at polar regions has been largely influenced by climate changes arising from global warming. In this context, based on ensemble simulations with a coupled model we evaluate the meridional shift of a climate signal (i.e., a cold and fresh water input pulse generated from melting of positive Antarctic sea ice (ASI) extremes) towards the Tropical Atlantic Ocean (TAO). This oceanic signal propagated from Southern Ocean towards the equator through the upper layers due to an increase in its buoyance. Its northward shift has given by the Subantarctic Mode Water (SAMW) and Antarctic Intermediate Water (AAIW) flows, that inject cold and fresh mode/intermediate waters from into subtropical basin. The signal has reached low latitudes through the equatorial upwelling and spreads out southwards, through the upper branch of southern subtropical gyre. We concluded that 10 years of coupled simulations was enough time to propagate the climate signal generated by ASI positive extremes melting, which reached TOA around 2 year later. The oceanic connection between Southern Ocean and TAO is indeed established within the timescale analyzed in the study (10 years). Nonetheless, the period needed to completely dissipate the disturbance generated from ASI seems to be longer.

https://doi.org/10.1590/0001-3765202220210800

12.

Effect of combining Zingiber officinale and Juglans regia extracts on Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis: antibiofilm action and low toxicity
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SILVA, LEONARDO A. DA

; RAMOS, LUCAS P.

; SILVA, TATIANE A.

; LAPENA, SIMONE A.B. DE

; SANTOS, CARLOS EDUARDO R.

; HASNA, AMJAD A.

; BRESSANE, ADRIANO

; OLIVEIRA, LUCIANE D. DE

Anais da Academia Brasileira de Ciências

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2022, Volumen 94 Nº 4 elocation e20201133

Resumen: En | Texto: En | PDF: En

Abstract Objective was evaluated the therapeutic effect of Juglans regia (J) and Zingiber officinale (Z) extracts, alone or associated (Z75% + J25%, Z50% + J50% and Z25% + J75%) applied on planktonic cultures and biofilms of Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus, as well as analyzing the cytotoxic effects of plant extracts on mouse macrophages (Raw 264-7). Broth microdilution assay was performed (M7-A6 - CLSI). Anti-biofilm activities and cytotoxicity on Raw 264-7 were studied using MTT assay and scanning electron microscopy. ANOVA with post-hoc Tukey HSD applied for parametric data and Kruskal-Wallis with Conover-Iman test, for non-parametric (p<0.05). On P. acnes biofilm, Z50% + J50% reduced 46.9% in 5 min and Z25% + J75% reduced 74.1% in 24hs. On S. aureus, Z75% + J25% reduced 23.1% in 5 min Z25% +J75% reduced 79.4% in 24hs. On S. epidermidis, Z75% + J25% reduced 74.6% in 5 min and 82.05% in 24 h. The treatments on macrophages for 24 h promoted a maximum reduction by 14,5% for groups of extracts associations. On multispecies biofilm, Z75%+J25% reduced 84.3% in 24 h. In conclusion association of glycolic extracts provided therapeutic effect, demonstrated antimicrobial activity and low cytotoxicity.

https://doi.org/10.1590/0001-3765202220201133

13.

Suplementação de Vitamina D Induz Remodelação Cardíaca em Ratos: Associação com a Proteína de Interação com a Tiorredoxina e a Tiorredoxina
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Santos, Priscila P. dos

; Rafacho, Bruna P. M.

; Gonçalves, Andrea F.

; Pires, Vanessa C. M.

; Roscani, Meliza G.

; Azevedo, Paula S.

; Polegato, Bertha F.

; Minicucci, Marcos F.

; Fernandes, Ana Angélica H.

; Tanni, Suzana E.

; Zornoff, Leonardo A. M.

; Paiva, Sergio A. R. de

Arquivos Brasileiros de Cardiologia

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Nov 2021, Volumen 116 Nº 5 Paginas 970 - 978

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: A vitamina D (VD) tem um importante papel na função cardíaca. No entanto, a vitamina exerce uma curva “dose-resposta” bifásica na fisiopatologia cardiovascular e pode causar efeitos deletérios, mesmo em doses não tóxicas. A VD exerce suas funções celulares ligando-se ao seu receptor. Ainda, a expressão da proteína de interação com a tiorredoxina (TXNIP) é positivamente regulada pela VD. A TXNIP modula diferentes visa de sinalização celular que podem ser importantes para a remodelação cardíaca. Objetivos: Avaliar se a suplementação com VD leva à remodelação cardíaca, e se a TXNIP e a tiorredoxina (Trx) estão associadas com esse processo. Métodos: Duzentos e cinquenta ratos Wistar machos foram alocados em três grupos: controle (C, n=21), sem suplementação com VD; VD3 (n = 22) e VD10 (n=21), suplementados com 3,000 e 10,000 UI de VD/ kg de ração, respectivamente, por dois meses. Os grupos foram comparados por análise de variância (ANOVA) com um fator e teste post hoc de Holm-Sidak (variáveis com distribuição normal), ou pelo teste de Kruskal-Wallis e análise post-hoc de Dunn. O nível de significância para todos os testes foi de 5%. Resultados: A expressão de TXNIP foi mais alta e a atividade do Trx foi mais baixa no grupo VD10. Os animais que receberam suplementação com VD apresentaram aumento de hidroperóxido lipídico e diminuição de superóxido dismutase e glutationa peroxidase. A proteína Bcl-2 foi mais baixa no grupo VD10. Observou-se uma diminuição na β-oxidação de ácidos graxos, no ciclo do ácido tricarboxílico, na cadeia transportadora de elétrons, e um aumento na via glicolítica. Conclusão: A suplementação com VD levou à remodelação cardíaca e esse processo pode ser modulado por TXNIP e Trx, e consequentemente por estresse oxidativo.

Abstract Background: Vitamin D (VD) has been shown to play an important role in cardiac function. However, this vitamin exerts a biphasic “dose response” curve in cardiovascular pathophysiology and may cause deleterious effects, even in non-toxic doses. VD exerts its cellular functions by binding to VD receptor. Additionally, it was identified that the thioredoxin-interacting protein (TXNIP) expression is positively regulated by VD. TXNIP modulate different cell signaling pathways that may be important for cardiac remodeling. Objective: To evaluate whether VD supplementation lead to cardiac remodeling and if TXNIP and thioredoxin (Trx) proteins are associated with the process. Methods: A total of 250 Male Wistar rats were allocated into three groups: control (C, n=21), with no VD supplementation; VD3 (n = 22) and VD10 (n=21), supplemented with 3,000 and 10,000 IU of VD/ kg of chow respectively, for two months. The groups were compared by one-way analysis of variance (ANOVA) and Holm-Sidak post hoc analysis, (variables with normal distribution), or by Kruskal-Wallis test and Dunn's test post hoc analysis. The significance level for all tests was 5%. Results: TXNIP protein expression was higher and Trx activity was lower in VD10. The animals supplemented with VD showed increased lipid hydroperoxide and decreased superoxide dismutase and glutathione peroxidase. The protein Bcl-2 was lower in VD10. There was a decrease in fatty acid β-oxidation, tricarboxylic acid cycle and electron transport chain with shift to increase in glycolytic pathway. Conclusion: VD supplementation led to cardiac remodeling and this process may be modulated by TXNIP and Trx proteins and consequently oxidative stress.

https://doi.org/10.36660/abc.20190633 352 descargas

14.

Characterization of Brachiaria decumbens ‘Basilisk’ pasture subjected to flexible grazing by sheep
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Conrado, Jefte A. de A.

; Lopes, Marcos N.

; Cândido, Magno J.D.

; Santos-Neto, Clemente F. dos

; Morais, Leonardo F. de

; Torres, Antônia F.F.

; Nascimento, Dayanne R. do

; Carneiro, Maria S. de S.

Chilean journal of agricultural research

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Sep 2021, Volumen 81 Nº 3 Paginas 338 - 350

Resumen: En | Texto: En | PDF: En

ABSTRACT The sustainability of animal production on pasture is based on improving the management of forage species used, which ensures increase in animal productivity, pasture perenniality and cost reduction. The objective was to characterize productive, structural, physiological and normalized difference vegetation index (NDVI) responses of Brachiaria decumbens Stapf ‘Basilisk’ over the flexibilization of the grazing management adopted. Four defoliation combinations were evaluated, which consisted of the arrangement of two (85% and 95%) light interceptions (LI) and two (1.3 and 1.8) residual leaf area indexes (RLAI), as parameters of entry and exit of the animals from the pasture, respectively. Higher total forage biomass was observed (TFB, kg DM ha-1) 18.82%, when the canopy was managed at the lowest defoliation frequencies (95% LI), but with a higher morphological composition of the stem component and dead material. The 95% LI produced an extra layer of leaves than the canopy managed at 85% LI. The physiological variables were affected by the higher frequency of defoliation (85% LI), with lower photosynthetic rates. NDVI was higher in the canopy managed in the pre-grazing condition at 95% LI (0.88) and residual condition at 1.8 RLAI (0.49), when compared to 85% LI (0.86) and 1.3 RLAI (0.44). For greater production per animal, managing at 85% LI × 1.8 RLAI with pre-grazing and residual NDVI of 0.85 and 0.49, respectively, is the most suitable while for greater animal production per area, managing at 95% LI × 1.3 RLAI with pre-grazing and residual NDVI of 0.88 and 0.44, respectively, becomes more efficient.

160 descargas

15.

Development of a TD-NMR Method to Monitor Brazil Nuts Oil Content: A Green and Low-Cost Based Approach
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Ribeiro, Úrsula A.

; Queiroz, Leonardo C.

; Marassi, Agide G.

; Carvalho, André S.

; Barros, Gabriel A.

; Consalter, Daniel M.

; Bezerra, Jaqueline A.

; Santos, Alan D. C.

; Colnago, Luiz Alberto

; Machado, Marcos B.

Journal of the Brazilian Chemical Society

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Jul 2021, Volumen 32 Nº 7 Paginas 1405 - 1412

Resumen: En | Texto: En | PDF: En

Growth in the international popularity of Brazil nuts oil (Bertholletia excelsa, Bonpl.) has demanded a closer look at quality aspects of the nuts. In this context, time-domain 1H nuclear magnetic resonance spectroscopy (TD-NMR) can be a useful tool for assessing the lipid portion of such matrices. In this work, a TD-NMR method was developed and validated to assess the oil content directly from Brazil nuts following the ISO 10565:1998 and DOQ-CGCRE-008. Full validation was addressed covering the working range from 0.67 to 25.00 g (coefficient of determination, R2= 0.9993). Limits of detection (LOD) and quantification (LOQ) were 0.20 and 0.67 g, respectively. The repeatability and intermediate precision assays met the guide requirements. Oil contents obtained in two laboratories (different equipment) were statistically similar (66.93 ± 4.69 and 70.13 ± 4.15%), highlighting the method’s robustness. The developed approach has the potential to be adopted as an industrial reference method for in situ monitoring of Brazil nuts oil contents.

https://doi.org/10.21577/0103-5053.20210039 105 descargas

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