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ABSTRACT Arenas Blancas is a poorly known fossiliferous site located in the lower reach of the Chasicó creek (Buenos Aires Province, Argentina), with great relevance from a biostratigraphic viewpoint. The Macrochorobates scalabrinii Biozone was defined in this site, proposed as the biostratigraphic basis of the early Huayquerian Stage/Age (Late Miocene); however, the geological context and faunal record of this site have never been studied in detail. In this work, we perform a multi-proxy analysis of the Arenas Blancas site, as well as a nearby site here called Curva de la Vaca, and provide new interpretations on their origin, age, and biostratigraphy. Sedimentological, stratigraphic, and geomorphological characteristics of both sites suggest that the sequences include fluvial/alluvial deposits that represent Quaternary terraces. The taxonomic analysis of the Arenas Blancas faunal assemblage evidences the presence of 14 mammal taxa, together with some fishes, reptiles, and birds; the assemblage is correlated with the assemblage from the Cerro Azul Formation assigned to the Chasicoan Stage/Age (Late Miocene), also recovered from the lower reach of the Chasicó creek. The use of the taxa proposed in previous works to characterize the Macrochorobates scalabrinii Biozone (including this species) is not supported due to their taxonomic status and/or temporal distribution. Taphonomic evaluation indicates that the assemblage is constituted by reworked specimens; in this frame, it is proposed that fluvio/alluvial events, occurred during the Late Pleistocene-Holocene, eroded the Upper Miocene substrate and reworked fossil remains. Based on the present evidence, the Macrochorobates scalabrinii Biozone is here rejected as a valid biostratigraphic unit.

RESUMEN Arenas Blancas es una localidad fosilífera poco conocida, ubicada en el curso inferior del arroyo Chasicó (provincia de Buenos Aires, Argentina), pero con gran relevancia desde el punto de vista bioestratigráfico. La Biozona Macrochorobates scalabrinii , propuesta como base bioestratigráfica del Piso/Edad Huayqueriense temprano (Mioceno tardío) fue definida en este sitio, aunque su contexto geológico y registro faunístico nunca han sido estudiados en detalle. En este trabajo analizamos el sitio Arenas Blancas desde diferentes perspectivas, como así también un sitio cercano aquí denominado Curva de la Vaca, a fin de aportar nuevas interpretaciones sobre su origen, edad y bioestratigrafía. Las características sedimentológicas, estratigráficas y geomorfológicas de ambos sitios sugieren que las secuencias aflorantes corresponden a depósitos fluviales/aluviales que representan terrazas cuaternarias. El análisis taxonómico de la asociación faunística de Arenas Blancas permitió reconocer 14 taxones de mamíferos, como así también peces, reptiles y aves. Esta asociación muestra una clara correlación con la asociación de la Formación Cerro Azul asignada al Piso/Edad Chasiquense (Mioceno tardío), también registrada en el curso inferior del arroyo Chasicó. Por otra parte, se considera que el uso de los taxones que caracterizan la Biozona Macrochorobates scalabrinii (incluyendo esta especie) no está avalado por su estatus taxonómico y/o su distribución temporal. El estudio tafonómico muestra que la asociación está constituida por especímenes retrabajados; en este contexto, se propone que los eventos fluviales/aluviales ocurridos durante el Pleistoceno tardío-Holoceno erosionaron el sustrato del Mioceno tardío y retrabajaron los restos fósiles. Sobre la base de la evidencia disponible, se rechaza la validez de la Biozona Macrochorobates scalabrinii como unidad bioestratigráfica.

https://doi.org/10.5027/andgeov50n1-3459

Association of rs142548867 (EEFSEC) and periodontitis Grade C in a young Brazilian population
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STOLF, Camila Schmidt

; TAIETE, Tiago

; NASCIMENTO, Paloma A. do

; PAZ, Hélvis E. S.

; SALLUM, Enílson Antônio

; RUIZ, Karina Gonzalez Silvério

; CASATI, Márcio Zaffalon

; CASARIN, Renato Corrêa Viana

Journal of Applied Oral Science

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2023, Volumen 31 elocation e20230058

Resumen: En | Texto: En | PDF: En

Abstract Periodontitis Stage III-IV, Grade C (PerioC) is a severe form of Periodontitis. The individual genetic background has been shown to be an important etiopathogenic factor for the development of this disease in young, systemically healthy, and non-smokers patients. Recently, after exome sequencing of families with a history of the disease, PerioC was associated with three single nucleotide variations (SNVs) – rs142548867 (EEFSEC), rs574301770 (ZNF136), and rs72821893 (KRT25) – which were classified as deleterious or possibly harmful by prediction algorithms. Objective Seeking to validate these findings in a cohort evaluation, this study aims to characterize the allele and genotypic frequency of the SNVs rs142548867, rs574301770, and rs72821893 in the Brazilian population with PerioC and who were periodontally healthy (PH). Methodology Thus, epithelial oral cells from 200 PerioC and 196 PH patients were harvested at three distinct centers at the Brazilian Southern region, their DNA were extracted, and the SNVs rs142548867, rs574301770, rs72821893 were genotyped using 5′-nuclease allelic discrimination assay. Differences in allele and genotype frequencies were analyzed using Fisher’s Exact Test. Only the SNV rs142548867 (C > T) was associated with PerioC. Results The CT genotype was detected more frequently in patients with PerioC when compared with PH subjects (6% and 0.5% respectively), being significantly associated with PerioC (odds ratio 11.76, p=0.02). Conclusion rs142548867 represents a potential risk for the occurrence of this disease in the Brazilian population.

https://doi.org/10.1590/1678-7757-2023-0058

Teste de Limiar de Desfibrilação e Seguimento a Longo Prazo de Pacientes com Cardiopatia Crônica da Doença de Chagas
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Campos, Marco Paulo Cunha

; Bernardes, Luiz Fernando Gouveia

; Melo, João Paulo Chaves de

; Santos, Lucas Corsino dos

; Teixeira, Cristiano Honório Ribeiro

; Pavão, Maria Licia Ribeiro Cury

; Arfelli, Elerson

; Scorzoni Filho, Adilson

; Rassi Jr, Anis

; Marin-Neto, José A.

; Schmidt, André

Arquivos Brasileiros de Cardiologia

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Dic 2022, Volumen 119 Nº 6 Paginas 923 - 928

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A morte súbita cardíaca (MSC) é a causa mais comum de óbito na cardiomiopatia crônica da doença de Chagas (CCDC). Visto que muitos pacientes com CCDC que são candidatos a receber um cardioversor desfibrilador implantável (CDI) atendem a critérios que sugerem alto risco de apresentarem limiares de desfibrilação elevados, sugere-se realizar um teste de limite de desfibrilação (LDF). Objetivos Investigamos o uso do teste de LDF em pacientes com CCDC, com enfoque nos óbitos relacionados ao implante do CDI e na ocorrência de eventos arrítmicos e o tratamento oferecido durante o seguimento de longo prazo. Métodos Avaliações retrospectivas de 133 pacientes com CCDC que receberam CDI, principalmente para prevenção secundária. Foram coletados dados demográficos, clínicos e laboratoriais, escore de Rassi e dados do teste de LDF. Adotou-se p<0,05 como estatisticamente significativo. Resultados A média de idade foi 61±13 anos, e 72% da amostra era do sexo masculino. A fração de ejeção basal do ventrículo esquerdo foi 40±15%, e o escore de Rassi médio foi 10±4 pontos. Não ocorreram óbitos durante o teste de LDF, e não foram documentadas falhas do CDI. Foi identificada relação entre escore de Rassi basal mais elevado e LDFs mais elevados (ANOVA =0,007). O tempo médio até o primeiro choque foi de 474±628 dias, mas a aplicação de choque foi necessária em apenas 28 (35%) pacientes com TV, visto que a maioria dos casos se resolveu espontaneamente ou através da programação de ATP. Após seguimento clínico de 1728±1189 dias, em média, ocorreram 43 óbitos, relacionados principalmente a insuficiência cardíaca progressiva e sepse. Conclusões Um teste de LDF de rotina pode não ser necessário para pacientes com CCDCs que receberam CDI para prevenção secundária. LDFs elevados parecem ser incomuns e podem estar relacionados a escore de Rassi elevado.

Abstract Background Sudden cardiac death is the most common cause of death in chronic Chagas cardiomyopathy (CCC). Because most CCC patients who are candidates for implantable cardioverter-defibrillators (ICD) meet criteria for high defibrillation threshold values, a defibrillator threshold test (DTT) is suggested. Objectives We investigated the use of DTT in CCC patients, focusing on deaths related to ICD and arrhythmic events, as well as treatment during long-term follow-up. Methods We retrospectively evaluated 133 CCC patients who received an ICD mainly for secondary prevention. Demographic, clinical, laboratory data, Rassi score, and DTT data were collected, with p < 0.05 considered significant. Results The mean patient age was 61 (SD, 13) years and 72% were men. The baseline left ventricular ejection fraction was 40 (SD, 15%) and the mean Rassi score was 10 (SD, 4). No deaths occurred during DTT and no ICD failures were documented. There was a relationship between higher baseline Rassi scores and higher DTT scores (ANOVA = 0.007). The mean time to first shock was 474 (SD, 628) days, although shock was only necessary for 28 (35%) patients with ventricular tachycardia, since most cases resolved spontaneously or through antitachycardia pacing. After a mean clinical follow-up of 1728 (SD, 1189) days, 43 deaths occurred, mainly related to progressive heart failure and sepsis. Conclusions A routine DTT may not be necessary for CCC patients who receive an ICD for secondary prevention. High DTT values seem to be unusual and may be related to high Rassi scores.

https://doi.org/10.36660/abc.20210770

[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
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Marin-Neto, José Antonio Rassi Jr., Anis Moraes Oliveira, Gláucia M. Lemos Correia, Luís Claudio Novaes Ramos Jr., Alberto Hasslocher-Moreno, Alejandro Marcel Luquetti Ostermayer, Alejandro Sousa, Andréa Silvestre de Amato Vincenzo de Paola, Angelo Sobral de Sousa, Antonio Carlos Pinho Ribeiro, Antonio Luiz Correia Filho, Dalmo Moraes de Souza, Dilma do Socorro Cunha-Neto, Edecio J. A. Ramires, Felix Bacal, Fernando Pereira Nunes, Maria do Carmo Martinelli Filho, Martino Ibrahim Scanavacca, Maurício Magalhães Saraiva, Roberto Alves de Oliveira Júnior, Wilson M. Lorga-Filho, Adalberto de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado Braga, Adriana Sarmento de Oliveira, Adriana V. L. Sarabanda, Alvaro Yecê das Neves Pinto, Ana Assis Lopes do Carmo, André Schmidt, André Costa, Andréa Rodrigues da Ianni, Barbara Maria Markman Filho, Brivaldo Eduardo Rochitte, Carlos Thé Macedo, Carolina Mady, Charles Chevillard, Christophe Bittencourt das Virgens, Cláudio Marcelo Nery de Castro, Cleudson De Paoli de Carvalho Britto, Constança Felícia Pisani, Cristiano do Carmo Rassi, Daniela C. Sobral Filho, Dario Rodrigues Almeida, Dirceu A. Bocchi, Edimar T. Mesquita, Evandro de Souza Nogueira Sardinha Mendes, Fernanda Pereira, Francisca Tatiana Sperandio da Silva, Gilberto Marcelo de Lima Peixoto, Giselle Glotz de Lima, Gustavo H. Veloso, Henrique Turin Moreira, Henrique Bellotti Lopes, Hugo Masciarelli Francisco Pinto, Ibraim Pinto Dias, João Carlos Bemfica, João Marcos Silva-Nunes, João Paulo Soares Barreto-Filho, José Augusto Kerr Saraiva, José Francisco Lannes-Vieira, Joseli Menezes Oliveira, Joselina Luzia V. Armaganijan, Luciana Martins, Luiz Cláudio C. Sangenis, Luiz Henrique Barbosa, Marco Paulo Almeida-Santos, Marcos Antônio Simões, Marcos Vinicius Shikanai-Yasuda, Maria Aparecida Vieira Moreira, Maria da Consolação Higuchi, Maria de Lourdes Costa Monteiro, Maria Rita de Cássia Felix Mediano, Mauro Felippe Maia Lima, Mayara T. Oliveira, Maykon Moreira Dias Romano , Minna Nitz, Nadjar de Tarso Jorge Medeiros, Paulo Vieira Alves, Renato Alkmim Teixeira, Ricardo Coury Pedrosa, Roberto Aras, Roque Morais Torres, Rosália dos Santos Povoa, Rui Manoel Rassi, Sérgio Gabriel Salles Xavier, Sérgio Marinho Martins Alves , Silvia B. N. Tavares, Suelene Lima Palmeira, Swamy da Silva Junior, Telêmaco Luiz da Rocha Rodrigues, Thiago Madrini Junior, Vagner Maia da Costa , Veruska Dutra, Walderez

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Fecha de publicación: 2022-10-11

Resumen: En Pt

This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp; Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities. nbsp; Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp; The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp; The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp; Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.

Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou. A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica. Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas. A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica. A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp; Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;

https://doi.org/10.1590/SciELOPreprints.4820

Teste de Limiar de Desfibrilação e Seguimento a Longo Prazo de Pacientes com Cardiopatia Crônica da Doença de Chagas
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Campos, Marco Paulo Cunha

; Bernardes, Luiz Fernando Gouveia

; Melo, João Paulo Chaves de

; Santos, Lucas Corsino dos

; Teixeira, Cristiano Honório Ribeiro

; Pavão, Maria Licia Ribeiro Cury

; Arfelli, Elerson

; Scorzoni Filho, Adilson

; Rassi Jr, Anis

; Marin-Neto, José A.

; Schmidt, André

Arquivos Brasileiros de Cardiologia

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2022, Nº ahead

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210770

Notas sobre la dieta y el hábitat del Gorrión-Montés paisa Atlapetes blancae (Passerellidae)
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Chaparro-Herrera, Sergio

; Hernández Schmidt, Mateo

; Lopera-Salazar, Andrea

Actualidades Biológicas

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Dic 2021, Volumen 43 Nº 115 elocation e6

Resumen: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Parte de los datos más relevantes y básicos para implementar medidas de conservación enfocadas en una especie, requieren de no más que un metódico registro de las observaciones. Presentamos los datos de dieta y estrategias de forrajeo de Atlapetes blancae, recopilados entre diciembre de 2018 y enero de 2020 en San Pedro de los Milagros, Santa Rosa de Osos y Llanos de Cuivá en Yarumal, Antioquia, Colombia. Presentamos también una descripción de su hábitat y comentarios sobre las estrategias posibles para implementar acciones de conservación. Esta información no solo aporta al conocimiento biológico de la especie, sino que también ofrece información crucial sobre la vegetación relacionada con A. blancae para que sea incluida en acciones de restauración ecológica, evitando así la pérdida del hábitat de esta ave endémica que se encuentra en la categoría máxima de amenaza a la extinción.

Abstract Some of the most relevant and basic data for implementing species-focused conservation measures require nothing more than a methodical record of observations. We present data on the diet and feeding strategies of Atlapetes blancae collected between December 2018 and January 2020 in San Pedro de los Milagros, Santa Rosa de Osos, and Llanos de Cuivá in Yarumal, Antioquia, Colombia. We also present a description of their habitat and comments on possible strategies to implement conservation actions. This information not only contributes to the biological knowledge of the species, but also offers crucial information about the vegetation related to A. blancae so that it can be included in the ecological restoration actions and thus avoid the loss of the habitat of this endemic bird that is in the highest category of threat of extinction.

https://doi.org/10.17533/udea.acbi/v43n115a06 71 descargas

Seismic site classification of the Costa Rican Strong-Motion Network based on V S30 measurements and site fundamental period
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Pinzón, Luis A.

; Leiva, Diego A. Hidalgo

; Moya-Fernández, Aaron

; Schmidt-Díaz, Victor

; Pujades, Luis G.

Earth Sciences Research Journal

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Dic 2021, Volumen 25 Nº 4 Paginas 383 - 389

Resumen: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN En este artículo, se propone una nueva clasificación de sitio para la Red de Acelerógrafos de Costa Rica (RACR). Se utiliza como referencia la clasificación de sitio del Código Sísmico de Costa Rica basada en la velocidad promedio de la onda de corte de los 30 m superiores (VS3g). El período fundamental del sitio (T f ) se incluye como parámetro para complementar la caracterización existente. Para ello, las mediciones de V S3gg de 52 estaciones acelerométricas se relacionan con el período fundamental del sitio, este obtenido a partir de relaciones espectrales H/V utilizando registros de la Base de Datos de Movimiento Fuerte de Costa Rica. Las relaciones H/V se estiman con espectros de respuesta de aceleración con 5% de amortiguamiento y con espectros de amplitud de Fourier tradicionales obtenidos de la ventana de ondas S. A partir de la relación entre V S3g y T f , fueron asignados diferentes rangos de T f a la clasificación de perfil de suelo existente y se propone un gráfico con tres líneas y cuatro áreas para clasificar las estaciones de la RACR. Estas líneas fueron graficadas a partir de la intersección de los valores asignados a cada clase de sitio. La clasificación de cada estación será la correspondiente a la zona donde se encuentre el conjunto de valores V S30 y T f . Con esta propuesta, ambos parámetros toman relevancia y se compensan, reduciendo las diferencias por posibles errores en las mediciones o interpretaciones.

ABSTRACT In this paper, the soil profile of the Costa Rican Strong-Motion Network (CRSMN) stations is classified based on actual measurements and seismic regulations. The soil classification of the Costa Rican Seismic Code based on the average shear-wave velocity of the top 30 m (V S3r ) is used as a reference. The site fundamental period (Tf) is included as a parameter to complement the existing characterization. For this, V S3gg measurements from 52 accelerometric stations are related to the site fundamental period obtained through horizontal-to-vertical spectral ratios (HVSR) using ground motion records from the Costa Rican Strong-Motion Database. The H/V ratios are estimated with 5% damped acceleration response spectra and with traditional Fourier amplitude spectra from the S-wave window. From the relation be-tween V S3g and Tf, different ranges of are assigned to the existing soil profile classification and a graph with three-lines and four-areas is proposed to classify the stations of the CRSMN. These lines are plotted from the intersection between values assigned to each site class. The assigned classification at each station will be the one corresponding to the area where the pair of values (V S3g - Tf) falls. With this proposal, both parameters take relevance and are compensated, reducing the differences due to possible errors in measurements or interpretations.

https://doi.org/10.15446/esrj.v25n4.93927 25 descargas

Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
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Benseñor, Isabela M.

; Sgarbi, José Augusto

; Janovsky, Carolina Castro Porto Silva

; Pittito, Bianca Almeida

; Diniz, Maria de Fátima Haueisen Sander

; Almeida, Maria da Conceição Chagas de

; Alvim, Sheila Maria

; Barreto, Sandhi M.

; Giatti, Luana

; Duncan, Bruce B.

; Schmidt, Maria Inês

; Fonseca, Maria de Jesus M.

; Griep, Rosane H.

; Molina, Maria del Carmen B.

; Mill, José Geraldo

; Santos, Itamar de Souza

; Goulart, Alessandra C.

; Lotufo, Paulo A.

Archives of Endocrinology and Metabolism

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Ago 2021, Volumen 65 Nº 4 Paginas 468 - 478

Resumen: En | Texto: En | PDF: En

ABSTRACT Objective: To evaluate incidence of subclinical and overt hyperthyroidism and hypothyroidism. Subjects and methods: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study of 15,105 civil servants, examined at baseline and over a 4-year follow-up. This analysis included 9,705 participants with normal thyroid function at baseline, follow-up information about thyroid function and with no report of using drugs that may interfere in the thyroid function. Thyroid function was defined by TSH/FT4 levels or routine use of thyroid hormones/anti-thyroid medications. Annual and cumulative (over 4-year) incidence rates were presented as percentages (95% Confidence Intervals). Results: The incidence of all overt and subclinical thyroid disease was 6.7% (1.73%/year): 0.19% for overt hyperthyroidism (0.048%/year), 0.54% for subclinical hyperthyroidism (0.14%/year), 1.98% for overt hypothyroidism (0.51%/year), and 3.99% for subclinical hypothyroidism (1.03%/year). The incidence of all thyroid diseases was higher in women, when compared to men, with a low women:men ratio (1.36). For Blacks the highest incidence was for overt hyperthyroidism, while for Whites, the highest incidence was for overt hypothyroidism. However, the highest incidence of overt hyperthyroidism was detected in Asian descendants. The presence of antithyroperoxidase antibodies at baseline was associated with higher incidence of overt thyroid diseases. Conclusion: These results showed a high incidence of hypothyroidism, which is compatible with a country with a more-than-adequate iodine intake. The low women:men ratio of the incidence of thyroid dysfunction highlights the importance of the diagnosis of thyroid diseases among men in Brazil.

https://doi.org/10.20945/2359-3997000000348 273 descargas

Risk factors for postoperative pulmonary complications and prolonged hospital stay in pulmonary resection patients: a retrospective study
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Bevilacqua Filho, Clovis T.

; Schmidt, André P.

; Felix, Elaine A.

; Bianchi, Fabiana

; Guerra, Fernanda M.

; Andrade, Cristiano F.

Brazilian Journal of Anesthesiology

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Ago 2021, Volumen 71 Nº 4 Paginas 333 - 338

Resumen: En | Texto: En | PDF: En

Abstract Background Postoperative pulmonary complications are the main cause of morbidity and mortality after pulmonary resection. This study was undertaken to determine the risk factors associated with postoperative pulmonary complications (PPCs) and length of hospital stay (LOS) in pulmonary resection patients in a tertiary teaching hospital in Brazil. Methods A retrospective data gathering from 196 patients who underwent pulmonary resection between 2012 and 2016 was conducted. Demographic and hospital admission data were collected from patients with complete medical records. Univariate analysis was performed, followed by Poisson's regression for predicting the prevalence of postoperative pulmonary complications and length of hospital stay. Results Thirty-nine patients (20%) displayed pulmonary complications in the postoperative period. The risk factors associated with an increased prevalence of postoperative pulmonary complications in a multivariate analysis were: American Society of Anesthesiologists physical status (ASA) ≥ 3 (PR 4.77, p = 0.03, 95% CI: 1.17 to 19.46), predicted diffusion capacity of the lungs for carbon monoxide- corrected single breath (PR 0.98, p < 0.001, 95% CI: 0.96 to 0.99) and age of the patient (PR 1.04; p = 0.01; 95% CI: 1.01 to 1.06). Those associated with an increased prevalence of prolonged hospital stay were: duration of surgical procedure longer than five hours (PR 6.94, p = 0.01, 95% CI: 1.66 to 12.23), male sex (PR 5.72, p < 0.001, 95% CI: 1.87 to 9.58), and presence of postoperative pulmonary complications (PR 11.92, p < 0.001, 95% CI: 7.42 to 16.42). Conclusions The rate of postoperative pulmonary complications in the study population is in line with the world average. Recognizing risk factors for the development of PPCs may help optimize allocation resources and preventive efforts.

https://doi.org/10.1016/j.bjane.2021.02.003 1062 descargas

10.

Valvuloplasty Without Prosthetic Ring or Band in Patients with Degenerative Mitral Regurgitation: Long-Term Results and Predictive Factors for Outcomes
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Kalil, Renato A. K.

; Belli, Karlyse C.

; Mattos, Mariana O. T. de

; Sffair, Rita de Cássia E.

; Santos, Sarah Ceolin Stein

; Fagundes, Vitória Recuero

; Abrahão, Rogério de Souza

; Albrecht, Álvaro Schmidt

; Sant'Anna, João Ricardo Michielin

; Prates, Paulo Roberto

; Nesralla, Ivo Abrahão

; Pivatto Júnior, Fernando

Brazilian Journal of Cardiovascular Surgery

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Ago 2021, Volumen 36 Nº 4 Paginas 476 - 483

Resumen: En | Texto: En | PDF: En

Abstract Introduction: Mitral valvuloplasty including ring/band support is widely performed despite potential drawbacks of rings. Unsupported valvuloplasty is performed in only a few centers. This study aimed to report long-term outcomes of patients undergoing unsupported valvuloplasty for degenerative mitral regurgitation (MR) and to identify predictive factors for outcomes. Methods: This is a retrospective cohort including patients undergoing mitral valve repair for degenerative MR from 2000 to 2018. The main techniques were Wooler annuloplasty and quadrangular resection. Kaplan-Meier curves and Cox regression models were used for statistical analysis. Results: One hundred fifty-eight patients were included (median age: 64.0 years). In-hospital mortality was 2.5%. Maximum follow-up was 19.6 years, with a median of 4.7 years (992 patient-years). Overall survival at 5, 10, and 15 years was 91.0% (95% confidence interval [CI]: 85.7-96.3), 87.6% (95% CI: 80.7-94.5), and 78.1% (95% CI: 65.9-90.3), respectively. The European System for Cardiac Operative Risk Evaluation (EuroSCORE) II was an independent predictor of late death (hazard ratio [HR] 1.42; P=0.016). Freedom from mitral reoperation at 5, 10, and 15 years was 88.1% (95% CI: 82.0-94.2), 82.4% (95% CI: 74.6-90.2), and 75.7% (95% CI: 64.1-87.3), respectively. Left atrial diameter > 56 mm was associated with late reintervention in univariate analysis (HR 1.06; P=0.049). Conclusion: Degenerative MR can be successfully treated with repair techniques without annular support, thus avoiding the technical and logistical drawbacks of ring/band implantation while maintaining good long-term results. EuroSCORE II was a risk factor for late death, and larger left atrium was associated with late reoperation.

https://doi.org/10.21470/1678-9741-2020-0520

11.

Light quality and sealing type affect in vitro growth and development of Capsicum frutescens cultivars
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GRIS, TAINARA

; PINHEIRO, MARCOS V.M.

; THIESEN, LEONARDO A.

; WEBLER, ANDERSON R.

; JUNGES, DIÉSSICA L.

; HOLZ, EVANDRO

; NAIBO, IURI

; BATISTA, DIEGO S.

; OTONI, WAGNER C.

; SCHMIDT, DENISE

Anais da Academia Brasileira de Ciências

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2021, Volumen 93 Nº 3 elocation e20190061

Resumen: En | Texto: En | PDF: En

Abstract The aim of this work was to evaluate the effect of five light qualities [fluorescent lamps (FL); white (WL), red (RL), blue (BL), or red/blue LEDs (RBL)] and two types of flask sealing (with or without porous membranes) in the in vitro germination and growth of two Capsicum frutescens cultivars (Espaguetinho and Cayenne). For this, two seeds were inoculated per flask (350 mL) containing 50 mL of MS medium with 100 mg L-1 myo-inositol, 30 g L-1 sucrose, 6.0 g L-1 agar, and pH 5.8 ± 0.1. The plants were kept under culture room conditions (16-h photoperiod, 25 ± 2°C and irradiance of 40 μmol m-2 s-1). The experiment was arranged in CRD, 2x5x2 factorial scheme (Cultivar X Light qualities X Sealing type). At 42 days, the following traits were evaluated: percentage of germination; root and shoot length; number of green leaves, senescent leaves and nodal segments; and fresh and dry weight. Plants grown under RL and BRL, showed greater number of green leaves, and longer shoots and roots. The use of porous membranes remarkably reduced the number of senescent leaves. Thus, the use of porous membranes, RL and BRL are recommended since they improve growth and development of pepper in vitro.

https://doi.org/10.1590/0001-3765202120190061 95 descargas

12.

Estudo Comparativo da Doença Coronariana Microvascular Causada por Doença de Chagas e por Outras Etiologias
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Campos, Felipe Araujo

; Magalhães, Mariana L.

; Moreira, Henrique Turin

; Pavão, Rafael B.

; Lima Filho, Moyses O.

; Lago, Igor M.

; Badran, André V.

; Chierice, João R. A.

; Schmidt, André

; Marin Neto, José Antonio

Arquivos Brasileiros de Cardiologia

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Dic 2020, Volumen 115 Nº 6 Paginas 1094 - 1101

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A doença de Chagas (DC) constitui uma causa potencial negligenciada de doença microvascular coronariana (DMC). Objetivos Comparar pacientes com DMC relacionada à DC (DMC-DC) com pacientes com DMC ligada a outras etiologias (DMC-OE). Métodos De 1292 pacientes estáveis, encaminhados para angiografia coronária invasiva para elucidar o padrão hemodinâmico e a causa de angina, 247 apresentaram coronárias subepicárdicas normais, e 101 foram incluídos após aplicação dos critérios de exclusão. Desses, 15 compuseram o grupo de DMC-DC e suas características clínicas, hemodinâmicas, angiográficas, e cintilográficas foram comparadas às do grupo de 86 pacientes com DMC-OE. O nível de significância estatística para todas as comparações adotado foi de 0,05. Resultados Pacientes com suspeita de DMC-DC apresentaram características antropométricas, clínicas e angiográficas, além de alterações hemodinâmicas e de perfusão miocárdica estatisticamente comparáveis às detectadas nos 86 pacientes com DMC-OE. Disfunção ventricular diastólica, expressa por elevada pressão telediastólica do ventrículo esquerdo, foi igualmente encontrada nos dois grupos. Entretanto, em comparação a esse grupo com DMC-OE, o grupo com DMC-DC exibiu fração de ejeção ventricular esquerda mais baixa (61,1 ± 11,9 vs 54,8 ± 15,9; p= 0,049) e mais elevado escore de mobilidade da parede ventricular (1,77 ± 0,35 vs 1,18 ± 0,26; p= 0,02). Conclusão A cardiomiopatia crônica da doença de Chagas esteve associada à etiologia de possível doença microvascular coronariana em 15% de amostra de 101 pacientes estáveis, cujo sintoma principal era angina requerendo elucidação por angiografia invasiva. Embora os grupos DMC-DC e DMC-OE apresentassem características clínicas, hemodinâmicas, e de perfusão miocárdica em comum, a disfunção global e segmentar do ventrículo esquerdo foi mais grave nos pacientes com DMC associada à DC em comparação à DMC por outras etiologias. (Arq Bras Cardiol. 2020; 115(6):1094-1101)

Abstract Background Chagas disease (CD) as neglected secondary form of suspected coronary microvascular dysfunction (CMD). Objectives Comparison of patients with CMD related to CD (CMD-CE) versus patients with CMD caused by other etiologies (CMD-OE). Methods Of 1292 stable patients referred for invasive coronary angiography to elucidate the hemodynamic pattern and the cause of angina as a cardinal symptom in their medical history, 247 presented normal epicardial coronary arteries and 101 were included after strict exclusion criteria. Of those, 15 had suspected CMD-CE, and their clinical, hemodynamic, angiographic and scintigraphic characteristics were compared to those of the other 86 patients with suspected CDM-OE. Level of significance for all comparisons was p < 0.05. Results Patients with suspected CMD-CE showed most anthropometric, clinical, angiographic hemodynamic and myocardial perfusion abnormalities that were statistically similar to those detected in the remaining 86 patients with suspected CMD-OE. LV diastolic dysfunction, expressed by elevated LV end-diastolic pressure was equally found in both groups. However, as compared to the group of CMD-OE the group with CMD-CE exhibited lower left ventricular ejection fraction (54.8 ± 15.9 vs 61.1 ± 11.9, p= 0.049) and a more severely impaired index of regional wall motion abnormalities (1.77 ± 0.35 vs 1.18 ± 0.26, p= 0.02) respectively for the CMD-OE and CMD-CE groups. Conclusion Chronic Chagas cardiomyopathy was a secondary cause of suspected coronary microvascular disease in 15% of 101 stable patients whose cardinal symptom was anginal pain warranting coronary angiography. Although sharing several clinical, hemodynamic, and myocardial perfusion characteristics with patients whose suspected CMD was due to other etiologies, impairment of LV segmental and global systolic function was significantly more severe in the patients with suspected CMD related to Chagas cardiomyopathy. (Arq Bras Cardiol. 2020; 115(6):1094-1101)

https://doi.org/10.36660/abc.20200381 562 descargas

13.

Criação e Implementação de um Banco de Dados Prospectivo e Multicêntrico de Pacientes com Infarto Agudo do Miocárdio: RIAM
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Vaz, Jacqueline

; Abelin, Anibal Pereira

; Schmidt, Marcia Moura

; Oliveira, Pedro Piccaro de

; Gottschall, Carlos A. M.

; Rodrigues, Clarissa Garcia

; Quadros, Alexandre Schaan de

Arquivos Brasileiros de Cardiologia

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Mar 2020, Volumen 114 Nº 3 Paginas 446 - 455

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento Registros multicêntricos representativos do mundo real podem fornecer informações importantes, mas existem poucos estudos descrevendo como implementar estas ferramentas. Objetivo Descrever o processo de implementação de um banco de dados em infarto agudo do miocárdio com supradesnivelamento do segmento ST (IAMCST) em um hospital de referência e sua aplicação para outros centros com uma plataforma online . Métodos Nossa instituição implementou em 2009 um Registro de Infarto Agudo do Miocárdio (RIAM), com a inclusão prospectiva e consecutiva de todos os pacientes com diagnóstico de IAMCST que internaram na instituição. No período de março de 2014 a abril de 2016 foi realizada a migração para o sistema online com o software REDCap e expansão do registro para outros centros. A plataforma REDCap é um software de uso gratuito disponibilizado pela Universidade Vanderbilt a instituições interessadas em pesquisa, mediante cadastramento prévio. Resultados Foram realizadas as seguintes etapas do aprimoramento e expansão do registro: 1. Padronização das variáveis; 2. Implementação do software REDCap ( Research Electronic Data Capture ) institucional; 3. Desenvolvimento de formulários de coleta de dados ( Case Report Form - CRF); 4. Expansão do registro para outros centros de referência utilizando o software REDCap; 5. Treinamento da equipe e dos centros participantes pelo POP (Procedimento Operacional Padrão). Conclusões A descrição da metodologia utilizada para implementar e expandir o RIAM pode auxiliar outros centros e pesquisadores a realizar estudos semelhantes, compartilhar informações entre instituições, o desenvolvimento de novas tecnologias em saúde e auxiliar nas políticas públicas em doenças cardiovasculares. (Arq Bras Cardiol. 2020; 114(3):446-455)

Abstract Background Multicenter registries representing the real world can be a significant source of information, but few studies exist describing the methodology to implement these tools. Objective To describe the process of implementing a database of ST-segment elevation acute myocardial infarction (STEMI) at a reference hospital, and the application of this process to other centers by means of an online platform. Methods In 2009, our institution implemented an Registry of Acute Myocardial Infarction (RIAM), with the prospective and consecutive inclusion of every patient admitted to the institution who received a diagnosis of STEMI. From March 2014 to April 2016, the registries were uploaded to a web-based system using the REDCap software and the registry was expanded to other centers. Upon subscription, the REDCap platform is a noncommercial software made available by Vanderbilt University to institutions interested in research. Results The following steps were taken to improve and expand the registry: 1. Standardization of variables; 2. Implementation of institutional REDCap (Research Electronic Data Capture); 3. Development of data collection forms (Case Report Form - CRF); 4. Expansion of registry to other reference centers using the REDCap software; 5. Training of teams and participating centers following an SOP (Standard Operating Procedure). Conclusion The description of the methodology used to implement and expand the RIAM may help other centers and researchers to conduct similar studies, share information between institutions, develop new health technologies, and assist public policies regarding cardiovascular diseases. (Arq Bras Cardiol. 2020; 114(3):446-455)

https://doi.org/10.36660/abc.20190036 2032 descargas

14.

Fungicidal potential of essential oils in control of Fusarium spp. and Sclerotinia sclerotiorum
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Fontana, Daniele Cristina

; Schmidt, Denise

; Kulczynski, Stela Maris

; Caron, Braulio Otomar

; Pretto, Matheus Milani

; Mariotto, Axel Bruno

; Santos, Jullie dos

; Holz, Evandro

Arquivos do Instituto Biológico

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2020, Volumen 87 elocation e0612019

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O uso de pesticidas com alta toxicidade para controlar patógenos do solo, como Fusarium spp. e Sclerotinia sclerotiorum, tem gerado preocupação, devido aos impactos irreversíveis causados no meio ambiente, além de selecionar isolados resistentes. Dessa forma, os óleos essenciais surgem como uma alternativa eficiente no controle de doenças. Diante da problemática de controle de patógenos do solo e alto potencial antimicrobiano que os óleos essenciais possuem, este trabalho teve como objetivo avaliar o potencial fungicida de óleos essenciais no controle de Fusarium spp. e S. sclerotiorum, in vitro. Utilizou-se um delineamento inteiramente randomizado, esquema fatorial 2×4×8, com dois isolados (Fusarium spp. e S. sclerotiorum), quatro óleos essenciais (Aloysia citriodora, Cymbopogon winterianus, Lippia alba e Ocimum americanum) e oito concentrações de óleo essencial (0,0; 0,2; 0,4; 0,6; 0,8; 1,0; 1,2 e 1,4 ?L·mL-1), com dez repetições. Os óleos essenciais inibiram o crescimento micelial dos fungos em diferentes concentrações, sendo seu potencial justificado pela presença de compostos químicos antifúngicos. Os óleos essenciais de A. citriodora, C. winterianus, L. alba e O. americanum apresentam alto potencial fungicida, sendo alternativas viáveis para formulação de produtos comerciais, impulsionando a indústria de agrotóxicos.

ABSTRACT The use of highly toxic pesticides to control soil pathogens, such as Fusarium spp. and Sclerotinia sclerotiorum has generated concern, due to the irreversible impacts caused on the environment, in addition to selecting resistant isolates. In this way, essential oils appear as an efficient alternative in control of diseases. Facing the problem of soil pathogens control and high antimicrobial fungicide that essential oils present, this work aimed to evaluate the in vitro fungicidal potential of essential oils in control of Fusarium spp. and S. sclerotiorum. A completely randomized design, factorial scheme 2×4×8 was used, with two isolates (Fusarium spp. and S. sclerotiorum), four essential oils (Aloysia citriodora, Cymbopogon winterianus, Lippia alba and Ocimum americanum), eight essential oil concentrations (0.0; 0.2; 0.4; 0.6; 0.8; 1.0; 1.2 and 1.4 ?L·mL-1), and ten replicates. The essential oils inhibited mycelial growth of the fungi in different concentrations, being their potential justified by the presence of antifungal chemical compounds. Essential oils of A. citriodora, C. winterianus, L. alba and O. americanum present high fungicidal potential, being viable alternatives for formulation of commercial products, boosting the pesticides industry.

https://doi.org/10.1590/1808-1657000612019 634 descargas

15.

Minerals and potentially toxic elements in corn silage from tropical and subtropical Brazil
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Motta, Antonio Carlos Vargas

; Araujo, Eloá Moura

; Broadley, Martin R.

; Young, Scott D.

; Barbosa, Julierme Zimmer

; Prior, Stephen A.

; Schmidt, Patrick

Revista Brasileira de Zootecnia

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2020, Volumen 49 elocation e20190214

Resumen: En | Texto: En | PDF: En

ABSTRACT Our aim was to assess the mineral composition of corn silages produced in four states of Brazil: Goiás, Minas Gerais, Paraná, and Santa Catarina. In total, seventy-three samples were analyzed. Total element content was extracted by HNO3 and H2O2 microwave-assisted digestion, and inductively coupled plasma-mass spectrometry (ICP-MS) was used to determine concentration. Of the 31 elements analyzed (Ag, Al, As, B, Ba, Be, Ca, Cd, Co, Cr, Cs, Cu, Fe, K, Li, Mg, Mn, Mo, Na, Ni, P, Pb, Rb, S, Se, Sr, Ti, Tl, U, V, and Zn), 21 had concentrations above equipment detection limits. No elements reached the maximum tolerable concentration, but concentrations of Ca (0.14-0.15%), Cu (3.4-5.6 mg kg−1), P (0.13-0.16%), S (0.06-0.08%), and Zn (13-19 mg kg−1) were below the adequate concentration for good nutritional balance. The strong and consistent correlation observed between Fe and Ti in silage samples indicated contamination by soil. Mean concentrations of Cu, Mn, Mo, P, S, and Zn were different among states, and canonic analyses successfully discriminate samples according to their state of origin. Minerals from corn silage should be considered when formulating balanced cattle diets. To ensure silage quality, farmers must adopt strategies that reduce contamination by soil during the ensiling process.

https://doi.org/10.37496/rbz4920190214 540 descargas

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