ABSTRACT Primary Progressive Aphasia (PPA) is a progressive language disorder associated with frontotemporal impairment and mainly affects the left hemisphere of the brain. In general, this condition compromises abilities related to comprehension and expression of language. The diagnosis of PPA depends on in-depth knowledge regarding functions of language, neurology, and neuropsychology. Speech and language therapists (SLTs) have a pivotal role in the diagnosis and rehabilitation of PPA. The absence of these professionals involved in the diagnosis and rehabilitation may reflect on the quality of care of people with PPA. Objective: To identify the sociodemographic, educational, and professional practice characteristics of SLTs who work with people with PPA in Brazil. Methods: An online questionnaire was disseminated to reach SLTs across Brazil. The questionnaire collected information regarding sociodemographics, training and education, practice (time, setting, service provision), and sources of referral. Results: The study included 71 participants (95.8% women). Specialization was the most frequent educational level followed by master’s degree, and participants where mainly from the Southeast and South regions of Brazil. Neurologists were the professionals who most referred patients with PPA to SLTs. Finally, SLTs worked primarily in homecare settings and provided mainly individual therapy services. Conclusion: SLTs who work with PPA in Brazil can be characterized mainly as professionals with postgraduate degrees, relatively young, and from the South and Southeast regions of Brazil.

RESUMO A afasia progressiva primária (APP) é um distúrbio progressivo da linguagem associado à atrofia de regiões frontotemporais predominantemente do hemisfério esquerdo do cérebro. De modo geral, a APP afeta as capacidades compreensivas e expressivas da linguagem. O diagnóstico depende de profissionais com profundo conhecimento das funções da linguagem, neurologia e neuropsicologia. A fonoaudiologia tem papel essencial no diagnóstico e reabilitação da APP, e a ausência de fonoaudiólogos nesses processos pode refletir na qualidade do cuidado das pessoas com APP. Objetivo: Identificar as características sociodemográficas, educacionais e de atuação profissional de fonoaudiólogos que atuam com APP no Brasil. Métodos: Foi distribuído um questionário em formato online para fonoaudiólogos de todo o Brasil. O questionário coletou informações sobre aspectos sociodemográficos, de formação, atuação profissional (tempo, local de atuação, tipo de serviço oferecido) e fontes de encaminhamento. Resultados: O estudo incluiu 71 participantes (95,8% mulheres). O nível educacional mais frequente foi a especialização, e as regiões demográficas com maior incidência de profissionais que atendiam APP foram as Regiões Sudeste e Sul do país. Os neurologistas foram os profissionais que mais encaminhavam pacientes com APP para os fonoaudiólogos. Por fim, os fonoaudiólogos atuavam, principalmente, em homecare e realizando, em sua maioria, terapia individual. Conclusão: Os fonoaudiólogos que atuam com APP no Brasil podem ser caracterizados principalmente como profissionais pós-graduados, relativamente jovens e das Regiões Sul e Sudeste do Brasil.

ABSTRACT Pesticides make an important contribution to increased global agricultural production; however, their intensive use represents a risk to biota in both the short and long terms. The physical and chemical characteristics of these compounds, as well as their versatility in agricultural, domestic, and public health use, have led them to become widely present in the environment. The objectives of this study were to evaluate the spatiotemporal distribution of pesticides in the surface water of the Ayuquila-Armería river and to conduct an ecotoxicological risk assessment in algae, macroinvertebrates, and fish. The presence of 11 analytes was determined, being λ-cyhalothrin, ametrine, and malathion the pesticides with highest concentrations, and carbendazim, malathion, and glyphosate those with the highest frequency of detection (> 70 %). The number of pesticides detected per sample presented no significant temporal differences, and there was no significant effect of the crops or vegetation adjacent to the study sites on the number of pesticides detected per sample. The sampling conducted in November 2019 (wet season) presented the greatest difference in concentrations of most pesticides, compared to the other samplings. The ecotoxicological risk assessment showed that the macroinvertebrates (Daphnia magna) are the most vulnerable to the concentrations of pesticides in surface water, followed by fish and algae. Regulation of the importation, trade, and management of malathion and λ-cyhalothrin is crucial in order to reduce the presence of their residues and the risks associated with them.

RESUMEN Los plaguicidas contribuyen de manera importante al aumento de la producción agrícola mundial; sin embargo, su uso intensivo representa un riesgo para la biota tanto a corto como a largo plazo. Las características físicas y químicas de estos compuestos, así como su versatilidad en el uso agrícola, doméstico y de salud pública, los han llevado a tener una amplia presencia en el ambiente. Los objetivos de este estudio fueron evaluar la distribución espaciotemporal de plaguicidas en agua superficial del río Ayuquila-Armería, y realizar una evaluación de riesgo ecotoxicológico en algas, macroinvertebrados y peces. Se determinó la presencia de 11 analitos, siendo la λ-cihalotrina, la ametrina y el malatión los plaguicidas con mayores concentraciones, en tanto que el carbendazim, el malatión y el glifosato fueron los de mayor frecuencia de detección (> 70 %). El número de plaguicidas detectados por muestra no presentó diferencias temporales significativas, y no hubo efecto significativo de los cultivos o la vegetación adyacente a los sitios de estudio sobre el número de plaguicidas detectados por muestra. El muestreo realizado en noviembre de 2019 (temporada de lluvias) presentó la mayor diferencia en las concentraciones de la mayoría de los plaguicidas, en comparación con los demás muestreos. La evaluación de riesgos ecotoxicológicos mostró que los macroinvertebrados (Daphnia magna) son los más vulnerables a las concentraciones de plaguicidas en el agua superficial, seguidos de los peces y las algas. La regulación de la importación, el comercio y la gestión del malatión y la λ-cihalotrina es fundamental para reducir la presencia de sus residuos y los riesgos asociados a ellos.

Abstract: Biosphere reserves have among their functions to support scientific research, education, training and monitoring. In the Cape Horn Biosphere Reserve (RBCH), created in 2005, this function has been fulfilled with the creation of the Omora Ethnobotanical Park in 2000, and its implementation in 2008 as a co-founder site of the Chilean Network of Studies Long-Term Socio- Ecological (LTSER-Chile). In 2016, this network has been strengthened with the addition of the new Cape Horn Long-Term Socio-Ecological Research Network (LTER-Cape Horn). The latter includes the Omora Ethnobotanical Park, and three new sites added to the monitoring of the sub-Antarctic Magellanic ecoregion. From south to north, the four sites are: (1) Gonzalo Island (56°31’S; 68°43’O), at the southern end of the Diego Ramírez Archipelago, with sub- Antarctic vegetation dominated by grasses and cryptogams, devoid of woody species; (2) Horn Island (55°58’S; 67°13’O), at the southern end of the Cape Horn Archipelago, hosting the southernmost forest ecosystems on the planet, which are dominated by the evergreen beech (Nothofagus betuloides); (3) Omora Ethnobotanical Park (54°57’S; 67°40’O), Navarino Island, an ideal site for studies on climate change and its impact on biota and sub-Antarctic ecosystems, since it protects a watershed that includes a representative mosaic of characteristic habitats of the RBCH in an altitudinal gradient with a thermal decrease analogous to that which occurs with increases in latitude; and (4) Caleta 2 de Mayo Site (54°52’S; 68°41’O), Yendegaia Bay, in an ecotonal zone between evergreen and deciduous forests (product of the local climate gradient), at a site that will be central to future connectivity between Continental Chile, Tierra del Fuego, Navarino Island, and the RBCH. In 2015, UNESCO approved the Report of the First Periodic Review of the RBCH that proposed the protection of the Diego Ramírez Archipelago and the creation of the Diego Ramírez Islands-Drake Passage Marine Park. This goal was achieved with the promulgation of this new park on February 2, 2018, and its entry into force on January 21, 2019 with the publication of the creation decree in the Diario Oficial of Chile. In this context, the new LTER-Cape Horn network acquires great local, national and global relevance. At the local scale, it covers a representative environmental heterogeneity of the great diversity of landscapes and terrestrial, freshwater and marine ecosystems of the RBCH and the sub-Antarctic Magellanic ecoregion. At the national scale, it incorporates sub-Antarctic sites, located at the southern end of South America, to LTSER-Chile and to the Monitoring Network of the Ministry of the Environment. On a global scale, the terrestrial ecosystems of the LTER-Cape Horn network stands out for two main reasons: (1) these sub-Antarctic ecosystems lack a geographical replicate in other continents of the southern hemisphere, and (2) high latitude ecosystems are especially sensitive to global climate change. Thus, the LTER-Cape Horn network helps to overcome critical geographical gaps in the implementation of the International Network for Long-Term Ecological Research (ILTER). In order to articulate these four sites and strengthen the training of technical capacities and knowledge transfer to decision makers in the area of special interest tourism and other sustainable economic activities, the LTER-Cape Horn network will be managed locally from the new Cape Horn Sub-Antarctic Center (Cape Horn Center) that will be inaugurated in Puerto Williams in 2021. The implementation of the LTER-Cape Horn network is based on a close collaboration with various public institutions: Ministry of National Assets, Ministry of the Environment, Subsecretary of Fisheries and Aquaculture of the Ministry of Economy Development and Tourism, National Forestry Service, General Water Directorate of the Ministry of Public Works, Navy of Chile, Chilean Police (Carabineros), Municipality of Cape Horn, Provincial Government of Chilean Antarctica, and the Regional Government of Magallanes and Chilean Antarctica. In the following phases, the LTER-Cape Horn network and the Cape Horn Center aim to strengthen the participation of the local community, especially the Yahgan Indigenous Community of Bahía Mejillones, artisanal fisheries, tour operators, and the educational community, including private actors. Located at the “southern summit” of the Americas, Puerto Williams, capital of the Chilean Antarctic Province emerges as a global hub for transdisciplinary sub-Antarctic research, equipped with a new center and the network of long-term socio-ecological studies. Collaboration with regional, national and international actors will allow the LTER-Cape Horn network and the Cape Horn Center to: (i) provide critical data, which will open up new opportunities for monitoring climate change and its impact on biodiversity and ecosystems in sub-Antarctic latitudes; (ii) consolidate long-term monitoring, which is an essential component to effectively design mitigation and adaptation actions; (iii) strengthen a local sustainable development model that, associated with the Cape Horn Biosphere Reserve, contributes from the south of the world, to a biocultural conservation model that meets the needs of socio-economic well-being and environmental sustainability at multiple regional and planetary scales.

resumen está disponible en el texto completo

Resumo O isolamento de Escherichia coli a partir de alimentos é uma grande preocupação, pois cepas patogênicas desta bactéria podem causar desde diarreia até síndrome hemolítico-urêmica. Diante do exposto, o objetivo do trabalho foi pesquisar genes de virulência em isolados de Escherichia coli provenientes do sururu Mytella guyanensis comercializado na cidade de Cachoeira, Bahia, Brasil. As amostras foram adquiridas de quatro comerciantes, sendo duas de mercados e duas em pontos de venda na feira livre da cidade de Cachoeira, acondicionadas em caixas isotérmicas com gelo reutilizável e transportadas até o laboratório para a análise. Após a análise microbiológica, as cepas de Escherichia coli foram isoladas em ágar Eosina Azul de Metileno e preservadas em caldo Brian Heart Infusion e glicerol a 15% e mantidas a - 20° C. A identificação dos genes de virulência nas cepas isoladas foi realizada utilizando primers específicos, por meio da Reação em Cadeia da Polimerase. Foram obtidos 24 isolados de Escherichia coli, destes a prevalência do gene elt , característico de Escherichia coli enterotoxigênica, foi de 75% dos isolados. Não houve a detecção dos genes stx e bfpA nos isolados, os quais são prevalentes nas cepas de Escherichia coli enterohemorrágica e Escherichia coli enteropatogênica, respectivamente. A presença do gene elt relacionado à virulência de Escherichia coli nos isolados de Mytella guyanensis revela a necessidade da melhoria no processamento, incluindo boas práticas de manipulação, armazenamento adequado e cocção previa ao consumo, visando a garantia da saúde do consumidor.

Abstract The isolation of Escherichia coli from food is a major concern. Pathogenic strains of these bacteria cause diseases which range from diarrhea to hemolytic-uremic syndrome. Therefore the virulence genes in E. coli isolates from the mussel ( Mytella guyanensis) commercialized in Cachoeira, Bahia, Brazil were investigated. Samples were purchased from four vendors: two from supermarkets and two from fair outlets. They were conditioned into isothermal boxes with reusable ice and transported to the laboratory for analysis. E. coli strains were isolated in eosin methylene blue agar, preserved in brain-heart infusion medium with 15% glycerol and stored at -20 °C, after microbiological analysis. Virulence genes in the isolated strains were identified by specific primers, with Polymerase Chain Reaction. Twenty-four isolates were obtained, with a prevalence of elt gene, typical from enterotoxigenic infection, in 75% of the isolates. The stx and bfpA genes, prevalent in enterohemorragic and enteropathogenic E. coli, respectively, were not detected. The occurrence of elt virulence-related gene in the E. coli isolates of Mytella guyanensis reveals urgent improvement in food processing, including good handling practices, adequate storage and cooking before consumption, to ensure consumer’s health.

Resumo Introdução O ritmo biológico está associado ao nível de alerta, desempenho cognitivo e humor dos indivíduos. Sua regularidade é essencial para preservar uma boa saúde e qualidade de vida. Objetivo Apresentar as etapas de construção da escala intitulada Biological Rhythm Interview of Assessment in Neuropsychiatry – Kids (BRIAN-K), criada para medir disrupturas do ritmo biológico em crianças e adolescentes brasileiros. Métodos Os itens foram desenvolvidos seguindo a versão adulta da escala. A análise das características psicométricas da escala se baseou nas respostas de 373 pais/cuidadores de crianças em idade escolar (7 e 8 anos). Resultados Um modelo teórico de 17 itens, com o objetivo de avaliar quatro domínios do ritmo biológico (sono, atividades, ritmo social e padrão alimentar) foi determinado usando análise fatorial exploratória (AFE) e pela identificação de um fator geral. As propriedades psicométricas da BRIAN-K mostraram-se satisfatórias. Conclusão Apenas dois itens precisaram ser reescritos. São necessários mais estudos para investigar a adequação do instrumento a diferentes faixas etárias e evidências adicionais de validade e confiabilidade.

Abstract Introduction Biological rhythm is associated with the level of alertness, cognitive performance and mood of the individuals. Its regularity is essential to preserve good health and quality of life. Objective To present the steps for the construction of the scale entitled Biological Rhythm Interview of Assessment in Neuropsychiatry – Kids (BRIAN-K), designed to measure biological rhythm disruptions in Brazilian children and adolescents. Methods Items were developed following the adult version of the scale. Analysis of the psychometric characteristics of the scale was based on the responses of 373 parents/caregivers of school age children (7 and 8 years old). Results A theoretical model of 17 items with the purpose of evaluating four domains (sleep, activities, social rhythm and eating pattern) was determined using exploratory factor analysis (EFA) and via identification of a general factor. The psychometric properties of the BRIAN-K showed favorable properties. Conclusion Only two items needed to be rewritten. Further studies are needed to investigate the instrument's adequacy to different age groups and additional evidence of validity and reliability.

ABSTRACT In the search for new anti-schistosomal agents, a series of fifteen ortho-nitrobenzyl derivatives was assayed in vitro against both the schistosomulum (somule) and adult forms of Schistosoma mansoni. Compounds 8 and 12 showed significant activity against somules at low micromolar concentrations, but none was active against adults. The SAR demonstrated that the compounds most active against the parasite were mutagenic to the human cell line RKO-AS45-1 only at concentrations 10- to 40-fold higher than the worm-killing dose. Given their electrophilicity, compounds were also screened as inhibitors of the S. mansoni cysteine protease (cathepsin B1) in vitro. Amides 5 and 15 exhibited a modest inhibition activity with values of 55.7 and 50.6 % at 100 µM, respectively. The nitrobenzyl compounds evaluated in this work can be regarded as hits in the search for more active and safe anti-schistosomal agents.

RESUMO Produtos naturais são classicamente usados em tratamento de feridas, para prevenção de infecção. A Própolis é um agente antimicrobiano natural bem estabelecido, o qual contém compostos fenólicos e flavonoides, cujos teores variam conforme a sua origem. A Própolis de origem britânica e a de origem brasileira, a romã, o sangue de dragão e a sálvia são agentes antimicrobianos utilizados em biomateriais. O objetivo deste trabalho foi a análise do teor de fenóis e flavonoides, da atividade antioxidante das mesmas e das ligações químicas presentes nesses compostos, usando FTIR. A análise de FTIR revelou a presença desses compostos ativos em todos os produtos analisados. A própolis brasileira é rica em fenóis comparada aos outros fitoterápicos, seguido de romã e própolis britânica. A própolis britânica é rica em flavonoides devido à sua origem. Romã, própolis britânica e sangue de dragão apresentaram as maiores atividades antioxidantes. Todas as amostras apresentaram atividade antioxidante superior a 82%.

ABSTRACT Natural products are used in wound healing in order to prevent infection. Propolis is a well known antimicrobial with phenolic compounds and flavonoid content which vary according to the propolis origin. Besides propolis (from both Brazilian and UK sources), pomegranate, dragon's blood and sage are possible antimicrobials to be used in biomaterials. The goal of this work was to analyze the amount of phenols and flavonoid compounds in these natural products, their antioxidant activities and the bonds present by FTIR. The FTIR analysis revealed the presence of active compounds in all drug samples. The phenols quantification showed that Brazilian propolis was rich in phenols compared to the other drugs, followed by pomegranate and UK propolis. UK propolis was the most rich in flavonoids, which is expected on account of its origin. Pomegranate, UK propolis and Dragon's blood presented the highest antioxidant activity. All samples presented antioxidant activity > 82%.

Resumo A presente pesquisa tem como proposta investigar as bases históricas da Universidade e analisar suas influências para o surgimento dos cursos Bacharelados Interdisciplinares na Universidade Federal da Bahia. Foi realizada uma revisão de literatura com o objetivo de compreender com maior clareza as novas contingências políticas, sociais e educacionais brasileiras que demandaram uma reformulação na arquitetura curricular e pedagógica, adequando-as à realidade do ensino superior no século XXI. A criação dos Bacharelados Interdisciplinares, pautada no sistema de ciclos, almeja responder as atuais demandas contemporâneas que necessitam, cada vez mais, de uma integração entre as várias áreas do conhecimento. Neste sentido, este estudo aponta para a necessidade de construção de uma nova Universidade, através da restruturação dos currículos universitários e do processo de autonomia do graduando em seu percurso formativo, fundamentado na epistemologia interdisciplinar com pilares coerentes com as novas demandas da atualidade.

Abstract This research aims to investigate the historic bases of the University and analyses its influences to the Interdisciplinary Bachelor degree programs created at the Universidade Federal da Bahia. Through a literature review, this study attempts to clearly understand the new Brazilian contingencies, whether political, social and educational, which result in a reformulation of the curricular and pedagogical structures, adapting them to the reality of the college education of the 21st century. The Interdisciplinary Bachelors programs´ conception, based on a cycle system, aims to answer the new contemporary demands which need, more and more, integration between the many parts of knowledge. Therefore, this study reflects the necessity to construct a new concept about university, through the restructuring of the university’s curriculum and the restructuring of the students’ autonomy in their academic trajectory. This new perspective must be based on an interdisciplinary epistemology, with pillars coherent with new demands.

RESUMO:Neste artigo apresentamos dados de pesquisa desenvolvida no programa de Pós-Graduação da FAE/UFMG em que tratamos sobre as implicações de se introduzir o computador como suporte de escrita na fase de alfabetização. Entre as referências estão os estudos sobre os letramentos, como aqueles produzidos por Magda Soares e Brian Street, e sobre a história da leitura e do livro e a história da cultura escrita. Na metodologia adotamos os princípios da pesquisa qualitativa, com proposta de intervenção colaborativa, com a proposição de acompanhar crianças de 6 anos em laboratório de informática de escola pública em Belo Horizonte, Minas Gerais, durante o ano de 2009, em várias situações de atividades de escritura e leitura na tela do computador, tanto na utilização de programas, atividades, jogos, como em atividades com gêneros da esfera digital.

ABSTRACT:This paper presents research data developed by the Graduate program FAE / UFMG. We treat the implications of introducing the computer as a writing support in literacy phase. Among the references are studies about literacy, such as those produced by Magda Soares (1998), Brian Street (2009), about the history of reading and the book (Chartier, 1997) and history of written culture (Gómez, 2003). Methodologically, we have adopted the principles of qualitative research, including proposals for collaborative intervention. We accompanied 6 years old children in public school computer labs in Belo Horizonte, Minas Gerais, during the year 2009 in various writing and reading on a computer screen situations and the use of programs, games, and activities with digital sphere genres.

Este artigo analisa comparativamente e avalia qualitativamente prioridades de competição em três cadeias de suprimentos da indústria petroquímica, A, B e C. A pesquisa foi feita no segundo semestre de 2006. O artigo revisa definições sobre cadeias de suprimentos, destacando principalmente a forma de rede que estas podem assumir. A seguir, apresenta os três casos estudados. A pesquisa identificou sete prioridades de competição em petroquímica: qualidade, entrega, flexibilidade, custo, inovação, comunicação e segurança, que foram desdobradas em dimensões. As prioridades foram ponderadas por gestores, com apoio do método multicriterial AHP, chegando-se a uma estrutura de competitividade, que apoiou a avaliação, baseada em julgamento. Ao fim, as diferenças entre as prioridades e os desempenhos julgados formaram uma estrutura de objetivos para as cadeias. A deve priorizar qualidade, B flexibilidade e C redução de custo.

The purpose of this article is to comparatively analyze and quantitatively assess the competitive priorities in three supply chains from the petrochemical industry: A, B, and C. The research was carried out in the second half of 2006. The article revises definitions on supply chains with emphasis on network shapes. Then, it presents the three case studies: A, B, and C. The research identifies seven competitive priorities in the petrochemical industry: quality, lead-time, flexibility, cost, innovation, communication and safety, which were unfolded in dimensions. The priorities were analyzed by managers with the support of the AHP multi-criteria method, reaching a competitiveness structure that supported the assessment based on judgment. Finally, the differences betweenthe priorities and the assessed performances formed a structure of objectives for the chains. Results showed that Ashould prioritize quality,B should prioritize flexibility, while C should prioritize cost reduction.

Cuantificamos la variación en el tamaño y forma del cuerpo y cabeza de Bolitoglossa vallecula en cuatro poblaciones de la Cordillera Central de Colombia. Dos de estas cuatro poblaciones ocurren en simpatría con B. ramosi una especie de salamandra ecológicamente similar que podría potencialmente competir con B. vallecula por recursos alimenticios. En ninguna de las poblaciones encontramos evidencias de dimorfismo sexual en el tamaño o forma de la cabeza, por lo tanto los datos de hembras y machos fueron agrupados. Las poblaciones difirieron significativamente en el tamaño promedio del cuerpo, pero esta variación no estuvo asociada con la elevación. Cuantificamos seis características de la forma de la cabeza asociadas con la morfología de la misma y las analizamos utilizando las proporciones de cada variable sobre la media geométrica, debido a que esta metodología es la más utilizada en la literatura para describir conformación mientras se controla por el efecto del tamaño. Una de las poblaciones simpátricas con B. ramosi (Bello) presentó diferencias significativas en la conformación de la morfología de la cabeza cuando se comparó con las poblaciones alopátricas, mientras que la otra población simpátrica no. Aunque en este trabajo la evidencia de desplazamiento de caracteres en respuesta a la competencia ecológica no es concluyente, este análisis destaca áreas de investigación que vale la pena adelantar en el futuro.

Body size and head shape variation was quantified in four populations of Bolitoglossa vallecula in the Cordillera Central of Colombia. Two of these four populations occurred in sympatry with B. ramosi, an ecologically similar salamander species that could potentially compete with B. vallecula for food resources. There was no evidence of sexual size or head shape dimorphism in any population, so data for males and females were pooled. The populations differed significantly in mean body size, but this variation was not associated with elevation. Six head shape characteristics associated with head morphology were quantified and analyzed using the ratio of each variable over the geometric median, given that this is the most preferred method in the literature for describing conformation while controlling for the effects of size. One of the populations sympatric with B. ramosi (Bello) exhibited significant differences in conformation of head morphology when compared to the allopatric populations, while the other sympatric population did not. While the evidence for character displacement due to ecological competition was equivocal, the analyses highlight areas where further research should be directed.

OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patients with multiple myeloma (a total of 70 interviews) using the two questionnaires. The scores upon diagnosis, post-treatment/pre-autologous stem cell transplantation, and at D+100 were compared using ANOVA (a comparison of the three groups), post hoc tests (two-by-two comparisons of the three groups), and paired t-tests (the same case at two different times). RESULTS: Of the included patients, 87.8% had a family budget under US $600 (economic class C, D, or E) per month. The generic Short Form 36 Health Survey questionnaire demonstrated that physical function, role-physical, and bodily pain indices were statistically different across all three groups, favoring the D+100 autologous stem cell transplantation group (ANOVA). The questionnaire specific for oncologic patients, the QLQ-C30 questionnaire, confirmed what had been demonstrated by the Short Form 36 Health Survey with respect to physical function and bodily pain, with improvements in role functioning, fatigue, and lack of appetite and constipation, favoring the D+100 autologous stem cell transplant group (ANOVA). The post hoc tests and paired t-tests confirmed a better outcome after autologous stem cell transplantation CONCLUSION: The questionnaire specific for cancer patients seems to be more informative than the generic Short Form 36 Health Survey questionnaire and reflects the real benefit of autologous stem cell transplantation in the quality of life of multiple myeloma patients in two public Brazilian institutions that provide assistance for economically challenged patients.

Estuda-se, numa amostra que contempla dois países - Portugal e Estados Unidos da América -, a estabilidade da qualidade da vinculação, na relação mãe criança, analisando-se o comportamento de base segura na relação mãe-criança nos primeiros anos de vida e as representações mentais da criança acerca desta relação, no pré-escolar. Os participantes são 25 díades mãe-criança portuguesas e 47 díades mãe-criança americanas. Utiliza-se o Attachment Behaviour Q-Set (AQS) (Waters, 1995) para avaliar os comportamentos de base segura e, três anos mais tarde, aplica-se às crianças o Attachment Story Completion Task (ASCT) (Bretherton & Ridgeway, 1990) que avalia a qualidade e a segurança das representações internas da relação de vinculação. Os resultados mostram que, nesta amostra, há uma estabilidade da vinculação entre os 2-3 anos de idade e os 5-6 anos de idade. O valor de segurança do AQS está correlacionado positiva e significativamente com a dimensão de segurança do ASCT. Nesta amostra, os modelos internos dinâmicos parecem permanecer relativamente estáveis ao longo de um período significativo de tempo.

Attachment Stability from infancy to preschoolers was studied in a sample that includes two countries - Portugal and the US -. The study examined associations between infant-mother secure base behaviour and attachment representation at preschooler years. 25 mother - child Portuguese dyads and 47 mother - child american dyads participated in the study. The quality of the children’s secure base behaviour was assessed with the Attachment Behaviour Q-Set (AQS) (Waters, 1995) and tree years later, to assess de quality and the security of the internal representations of the attachment relationship it was used Attachment Story Completion Task (ASCT) (Bretherton & Ridgeway, 1990). Correlations between AQS security and ASCT security were found. In this sample, internal working models seem to be relatively stable over a significant period of time.