This work describes a green synthesis, the characterization, and biological evaluation of silver nanoparticles (AgNPs). The AgNPs suspension was synthesized using aqueous leaf extract of Eucalyptus grandis, which presented a characteristic band at 407 nm in the UV-Vis spectrum. The AgNPs presented a spherical shape and size of 9.7 ± 0.3 nm. The nanoparticles were stable over a month, indicating that E. grandis’ extract is suitable for their preparation and stabilization. The X-ray analysis showed that the crystallinity of AgNPs corresponded to the centered face phase of silver. The antibacterial and leishmanicidal activities of AgNPs were evaluated. The AgNPs presented antibacterial activity on the Gram-negative bacteria Escherichia coli at 53.9 µg mL-1. The leishmanicidal activity evaluation against promastigote forms of Leishmania infantum, Leishmania amazonensis, and Leishmania braziliensis showed that the biological response is dependent on the volume of AgNP suspension. It was demonstrated that L. infantum was more sensitive to the nanoparticle’s treatment than L. amazonensis and L. braziliensis. The treatment of L infantum promastigotes with 150 µL of AgNP suspension reduced parasite growth by 67.9%, a result which was similar to the treatment with 1 (66.7%) or 2 µL (70.6%) of amphotericin B used as a positive control.

Lung transplantation is a well-established treatment for advanced lung diseases. In children, the diseases that most commonly lead to the need for a transplantation are cystic fibrosis, pulmonary hypertension, and bronchiolitis. However, the number of pediatric lung transplantations being performed is low compared with the number of transplants performed in the adult age group. The objective of this study was to demonstrate our experience with pediatric lung transplants over a 10-year period in a program initially designed for adults.

Neste artigo, provamos que se um operador de Nemytskii aplica Lp(ômega, E) no Lq(ômega , F), para p, q maiores do que 1, E, F espaços de Banach separáveis e F reflexivo, então uma seqüência que converge fracamente e q.t.p. é transformada em uma seqüência fracamente convergente. Fornecemos um contra-exemplo mostrando que se q = 1 e p é maior do que 1, podemos não ter continuidade seqüêncial de tal operador. Contudo provamos que se p = q = 1, então seqüências fracamente convergentes que convergem q.t.p. são aplicadas em seqüências fracamente convergentes por um operador de Nemytskii. Mostramos uma aplicação da continuidade fraca dos operadores de Nemytskii resolvendo uma equação funcional não linear no W1,p(ômega), provando a continuidade fraca de um tipo de operador resolvente associado ao operador de Nemytskii e obtendo um resultado de regularidade de tal solução.

In this paper, we prove that if a Nemytskii operator maps Lp(omega, E) into Lq(omega, F), for p, q greater than 1, E, F separable Banach spaces and F reflexive, then a sequence that converge weakly and a.e. is sent to a weakly convergent sequence. We give a counterexample proving that if q = 1 and p is greater than 1 we may not have weak sequential continuity of such operator. However, we prove that if p = q = 1, then a weakly convergent sequence that converges a.e. is mapped into a weakly convergent sequence by a Nemytskii operator. We show an application of the weak continuity of the Nemytskii operators by solving a nonlinear functional equation on W1,p(omega), providing the weak continuity of some kind of resolvent operator associated to it and getting a regularity result for such solution.