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Abstract In the modern world, cancer is a growing cause of mortality, but archeological studies have shown that it is not exclusive to modern populations. The aim of this study is to examine the epidemiologic, social, and clinicopathologic features of head and neck cancers in ancient populations. To do this, we extracted all records that described malignant lesions in the head and neck region available in the Cancer Research in Ancient Bodies Database (CRAB). The estimated age, sex, physical condition of the remains (skeletonized, mummified), anatomic location of tumors, geographic location, chronology, tumor type, and methods of tumor diagnosis were collected. One hundred and sixty-seven cases were found, mostly originating from Europe (51.5%). Most records were of adults between 35 and 49 years of age (37.7%). The most involved site was the skullcap (60.4%), and the most common malignancies were metastases to the bone (65.3%) and multiple myeloma (17.4%). No primary soft tissue malignancies were registered. The results of our study indicate that head and neck cancers were present in ancient civilizations, at least since 500,000 BCE. The available data can help to improve the current understanding of the global distribution of head and neck cancer and its multidimensional impacts on populations in the contemporary world.

https://doi.org/10.1590/1807-3107bor-2024.vol38.0014

Active search screening for oral potentially malignant disorders and oral cancer in the city of Piracicaba
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LINARES, Matheus Ferreira

; LOPES, Silvia Maria Paparotto

; MOREIRA, Adriana Eliza Brasil

; VARGAS, Pablo Agustin

; SILVA, Alan Roger dos Santos

; LOPES, Márcio Ajudarte

Brazilian Oral Research

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2023, Volumen 37 elocation e015

Resumen: En | Texto: En | PDF: En

Abstract Oral cancer is a public health problem worldwide with approximately 300,000 new cases diagnosed every year and more than 170,000 deaths annually. Squamous cell carcinoma (SCC) accounts for approximately 90% of all oral malignancies and it is frequently preceded by lesions known as oral potentially malignant disorders (OPMDs). Screening programs for early detection of oral lesions have been conducted. Therefore, the objective of this research was to carry out an active search in a screening program in the city of Piracicaba, Brazil. High-risk patients were identified at the city’s health center through their medical records and referred for dental consultation. Other patients who opportunistically sought dental care were also seen and if they did not present risk factors for SCC, they were considered low-risk. A total of 756 patients were examined, and 445 met the criteria for the high-risk group and 311 for the low-risk group. It was possible to diagnose 27 OPMDs and six SCCs – 21 OPMDs and six SCCs occurred in high-risk patients and six OPMDs in low-risk patients. A chi-square test was applied and a statistically significant value (p = 0.006) was obtained for the detection of OPMD and SCC in patients of the high-risk group. Screening of high-risk patients through active search proved to be an effective program for diagnosing OPMD and SCC. Therefore, we encourage its implementation on a large scale to reduce the current scenario of this disease.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0015

Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study
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KIRSCHNICK, Laura Borges

; SILVEIRA, Felipe Martins

; SCHUCH, Lauren Frenzel

; VASCONCELOS, Ana Carolina Uchoa

; GOMES, Ana Paula

; SANTOS, Jean Nunes dos

; SANTANA, Dandara Andrade

; FONSECA, Felipe Paiva

; MESQUITA, Ricardo Alves

; MENDONÇA, Elismauro Francisco de

; SOUSA-NETO, Sebastião Silvério

; PONTES, Hélder Antônio Rebelo

; ROBINSON, Liam

; HEERDEN, Willie van

; CARLOS-BREGNI, Román

; TAGER, Elena María José Román

; SILVA, Luan César da

; ZANELLA, Virgílio Gonzales

; RIVERO, Luis Fernando

; BITTENCOURT, Raquel

; MARTINS, Marco Antonio Trevizani

; LOPES, Márcio Ajudarte

; WAGNER, Vivian Petersen

; VARGAS, Pablo Agustin

; MARTINS, Manoela Domingues

Brazilian Oral Research

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2023, Volumen 37 elocation e050

Resumen: En | Texto: En | PDF: En

Abstract The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0050

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2023, Volumen 37 elocation e126

Resumen: En | Texto: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

Gingival cyst of the adult
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Mota, Maria Emília

; Oliveira, Dandara Menezes de Araujo

; Medeiros, Yuri de Lima

; Moreira, Maria Stella

; Lopes, Rodrigo Nascimento

; Alves, Fábio Abreu

; Louredo, Brendo Vinícius Rodrigues

; Vargas, Pablo Agustin

; Prado, José Divaldo

Autopsy and Case Reports

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2023, Volumen 13 elocation e2023454

Resumen: En | Texto: En | PDF: En

ABSTRACT The gingival cyst of the adult (GCA) is a rare odontogenic cyst, consisting of 0.3% of all odontogenic cysts. This case report, based on CARE guidelines for case reports, aims to present a case of a 52-year-old female patient with a symptomatic translucent nodule in the upper left anterior gingiva, measuring approximately 6mm. Excisional biopsy was performed, and the histological examination revealed multiple cystic cavities lined by the squamous epithelium of varying thickness with focal areas of nodular thickenings. The presence of clusters of cells with clear cytoplasm within epithelial thickenings was observed. PAS staining was negative in clear cells. The diagnosis of the GCA was established. Despite its rarity, GCA should be considered in the differential diagnosis of gingival lesions. Conservative surgical treatment proved to be effective, with no signs of recurrence.

https://doi.org/10.4322/acr.2023.454

Biochemistry response of Paronychia microphylla Phil., Ambrosia artmisiodes Phil. and Crotón ruizianus Müll. Arg. against mercury for its bioprospecting in phytoremediation
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Vilca Tisnado, Helen Kimberly

; Delgado Osorio, Melissa Karolyn

; Romero Vargas, Frey Francisco

; Mestas Valdivia, Bertha Roxana

; Quipuscoa Silwstre, Victor

; Lima Coasaca, Raúl

; Portilla Llerena, Juan Pablo

; Navarro Oviedo, Ronald Demetrio

Idesia (Arica)

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Dic 2022, Volumen 40 Nº 4 Paginas 91 - 99

Resumen: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Mercury (Hg) is one of the most toxic heavy metals, and it is largely used in illegal gold extraction in Peru. We evaluated the tolerance to Hg in Paronychia microphylla Phil, Ambrosia artemisioides Willd and Croton ruizianus Müll. Arg. plants, using controlled concentrations (5, 10 and 80 mg Hg L-1). Two groups were identified according to the antioxidant enzymatic and bioaccumulation response, but the changes in the soluble protein suggest other tolerance mechanisms in the species. P. microphylla has an accumulator performance (BCF = 1.16 at 10 mg Hg L-1); in contrast, C. ruizianus has a exclusor behavior with low BCF and better antioxidant response. In that sense, the concentration of 5 mg Hg L-1 triggers the oxidative stress and increases the levels of malondialdehyde and proline, but when treatment concentration increases there is regulation in the antioxidant system. Among the three species, C. ruizianus Müll. Arg. has the better antioxidant response, but the lower bioaccumulation.

RESUMEN El mercurio (Hg) es uno de los metales pesados más tóxicos y se utiliza principalmente en la extracción ilegal de oro en Perú. Se evaluó la tolerancia a Hg en en plantas de Paronychia microphylla Phil, Ambrosia artemisioides Willd y Croton ruizianus Müll. Arg., utilizando concentraciones controladas (5, 10 y 80 mg Hg L -1 ). Se identificaron dos grupos, según la respuesta antioxidante enzimática y de bioacumulación, pero los cambios en la proteína soluble sugieren otros mecanismos de tolerancia en las especies. P. microphylla tiene un desempeño acumulador (BCF = 1,16 a 10 mg Hg L-1); por el contrario, C. ruizianus tiene un comportamiento excluyente con bajo BCF y mejor respuesta antioxidante. En ese sentido, la concentración de 5 mg Hg L- 1 , desencadena estrés oxidativo y aumenta los niveles de malondialdehído y prolina, pero cuando aumenta la concentración del tratamiento hay regulación en el sistema antioxidante. Entre las tres especies, C. ruizianus Müll. Arg. tiene la mejor respuesta antioxidante, pero la menor bioacumulación.

The need for communication between clinicians and pathologists in the context of oral and maxillofacial diseases
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PÉREZ-DE-OLIVEIRA, Maria Eduarda

; HEERDEN, Willie van

; MOTTA, Ana Carolina Fragoso

; RODRIGUES-FERNANDES, Carla Isabelly

; ROMAÑACH, Mário José

; AGOSTINI, Michelle

; GUEIROS, Luiz Alcino Monteiro

; VARGAS, Pablo Agustin

; LOPES, Márcio Ajudarte

; RIBEIRO, Ana Carolina Prado

; BRANDÃO, Thaís Bianca

; ALMEIDA, Oslei Paes de

; KHURRAM, Syed Ali

; SANTOS-SILVA, Alan Roger

Brazilian Oral Research

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2022, Volumen 36 elocation e008

Resumen: En | Texto: En | PDF: En

Abstract Good communication between clinicians and pathologists is a vital element in the diagnostic process, and poor communication can adversely affect patient care. There is a lack of research about communication in diagnostic oral and maxillofacial pathology. This narrative review explores different aspects of the quality of communication between clinicians and oral pathologists, with a focus on the diagnosis of oral and maxillofacial diseases. An electronic search was carried out in MEDLINE through the PubMed, Scopus, and Embase databases up to April 2021. No studies reporting communication, its adequacy or the required skills between clinicians and pathologists in oral diagnosis were found. According to studies published in medicine, strategies for improving communication skills include clinician-pathologist collaboration; a well-formatted, clear and thorough report; training in communication skills; and patient-centered care. Further studies evaluating the current practices and quality in oral and maxillofacial pathology are required to identify barriers and encourage optimal communication to facilitate diagnosis, as well as patient safety.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0008

Preservation of immunoexpression of type I collagen, BSP and BMP4 in the dentin-pulp complex of head and neck cancer patients after radiotherapy
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FONSÊCA, Jéssica Montenegro

; MARTINS, Manoela Domingues

; VARGAS, Pablo Agustin

; SILVA, Wagner Gomes

; NORMANDO, Ana Gabriela Costa

; PALMIER, Natália Rangel

; RIBEIRO, Ana Carolina Prado

; BRANDÃO, Thaís Bianca

; LOPES, Márcio Ajudarte

; GOES, Mário Fernando de

; SANTOS-SILVA, Alan Roger

Brazilian Oral Research

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2022, Volumen 36 elocation e012

Resumen: En | Texto: En | PDF: En

Abstract This study tested the hypothesis that head and neck radiotherapy (HNRT) impacts the immunoexpression of type I collagen, bone sialoprotein (BSP) and bone morphogenetic protein 4 (BMP4), thereby leading to micromorphological changes in the dentin-pulp complex (DPC), and promoting the onset and progression of radiation caries (RC). Twenty-two demineralized sections of carious teeth (a group of 11 irradiated teeth and a control group of 11 non-irradiated teeth) extracted from 19 head and neck cancer patients were analyzed by conventional optical microscopy and immunohistochemistry to investigate the micromorphology (cellular layer hierarchy, blood vessels, odontoblasts, fibroblasts, extracellular matrix, calcification, necrosis, reactionary dentin formation, and chronic inflammation), and the patterns of staining/immunolocalization of type I collagen, BSP and BMP4 in the dental pulp of irradiated and control samples. No significant differences attributable to the direct impact of radiotherapy were detected in DPC micromorphology between the groups. In addition, the patterns of immunohistochemical staining and immunolocalization of the proteins studied did not differ between the irradiated and the control samples for type I collagen, BSP or BMP4. This study rejected the hypothesis that HNRT directly damages dentition by changing the organic components and the microstructure of the DPC, ultimately leading to RC.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0012

Ossifying fibromyxoid tumor of the oral cavity: rare case report and long-term follow-up
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Pérez-de-Oliveira, Maria Eduarda

; Morais, Thayná Melo de Lima

; Lopes, Márcio Ajudarte

; Almeida, Oslei Paes de

; van Heerden, Willie F. P.

; Vargas, Pablo Agustin

Autopsy and Case Reports

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2021, Volumen 11 elocation e2020216

Resumen: En | Texto: En | PDF: En

ABSTRACT Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal soft tissue benign neoplasm with an uncertain line of differentiation, which arises most frequently in extremities. The head and neck region involvement is uncommon, with only ten intraoral cases published in the English-language literature. One additional case of OFMT is reported here, including a literature review of intraoral reported cases. A 45-year-old female patient presented a painless nodule involving the buccal mucosa of approximately two years duration, measuring nearly 1.3 cm in maximum diameter. The main histopathological features include ovoid to round cells embedded in a fibromyxoid matrix with a perpheral shell of lamellar bone. Immunohistochemically, the tumor showed immunoreactivity for vimentin and S100. No recurrence has been detected after 7 years of follow-up.

https://doi.org/10.4322/acr.2020.216 317 descargas

10.

Non-ulcerated necrotizing sialometaplasia may mimic a salivary gland tumor
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Fernandes, Patrícia Maria

; Pedroso, Erika Graf

; Santos-Silva, Alan Roger

; Vargas, Pablo Agustin

; Lopes, Márcio Ajudarte

Autopsy and Case Reports

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2021, Volumen 11 elocation e2021244

Resumen: En | Texto: En | PDF: En

ABSTRACT Necrotizing sialometaplasia (NS) is a benign, self-limiting inflammatory entity that mainly affects the minor salivary glands located in the hard palate. Classically, NS is characterized as a nodule that evolves to a central ulcer. The most widely recognized triggering factor is an ischemic event. The diagnosis becomes a challenge in non-ulcerated NS cases which is essential to rule out the possibility of salivary gland tumors, especially the malignant ones. Here, we presented a case of a 32-year-old male patient with a 1-month complaint of a painful, slightly elevated erythematous area on the hard palate. Incisional biopsy was performed, and NS was diagnosed based on histopathological and immunohistochemical analyses. Clinicians should be aware of and consider NS as a differential diagnosis of minor salivary gland tumors, particularly when it presents as a non-ulcerated clinical aspect.

https://doi.org/10.4322/acr.2021.244 200 descargas

11.

Evaluation of the quality of referral letters: experience of a Brazilian oral medicine service
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Rodrigues, Camila Real Delegá

; Fernandes, Patrícia Maria

; Santos-Silva, Alan Roger

; Vargas, Pablo Agustin

; Lopes, Marcio Ajudarte

Brazilian Oral Research

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2021, Volumen 35 elocation e037

Resumen: En | Texto: En | PDF: En

Abstract: Optimizing the quality of referral letters could be the first step to a correct clinical approach for patients. Referral letters should be legible and contain the necessary information to avoid delaying the patient's diagnosis and treatment. However, to date, few studies have been conducted on how referrals are performed in Brazil. Knowledge regarding the quality of referral letters can provide information to better guide health care professionals. This study was aimed at analyzing all referrals received by a single oral medicine service in Brazil. Referral letters were classified into poor, regular, good, and excellent based on key items concerning the primary morphology of the lesion, location, diagnostic hypothesis, symptomatology, time of evolution, consistency, size, and limits. A total of 500 referral letters were evaluated, including 271 (54.2%) from a private service and 229 (45.8%) from a public service. Dentists and physicians had written 475 (95%) and 25 (5%) referral letters, respectively. Among the 500 referrals analyzed in this study, the number of regular, poor, good, and excellent referrals was 236 (47.2%), 203 (40.6%), 58 (11.6%), and one (0.6%), respectively, showing a lack of important clinical information in referrals.

https://doi.org/10.1590/1807-3107bor-2021.vol35.0037 284 descargas

12.

Diversidad genética en poblaciones de Pinus remota (Pinaceae) del Noreste de México: evidencias de declinamiento demográfico histórico
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González Jiménez, Aridahí

; Delgado Valerio, Patricia

; Molina Sánchez, Agustín

; Flores López, Celestino

; Vargas Gutierrez, Juan Pablo

; García Magaña, J. Jesús

Acta botánica mexicana

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2021, Nº 128 elocation e1890

Resumen: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Background and Aims: The decrease and fragmentation of populations result in the loss of variation and increase in genetic differentiation. Pinus remota is an arboreal-shrubby species of restricted distribution with scattered and fragmented populations. The objectives of the present study were: to evaluate the levels of genetic variation, inbreeding and the effective size of the populations, to test the hypothesis of the existence of bottlenecks associated with the reduction of the genetic variation of the populations, and to analyze the genetic structure and its association with the geographic distribution of populations. Methods: The study was carried out in seven representative populations of their natural distribution in Mexico, by screening a total of 112 trees with five nuclear microsatellites. The data were evaluated with parameters of population genetics and Bayesian approach methods. Key results: The average expected heterozygosity (He=0.557) was higher than the observed heterozygosity (Ho=0.375). The populations are not in Hardy-Weinberg equilibrium, with significant inbreeding levels (FIS=0.259) and small effective sizes (Ne between 375-425). These are structured in three genetic groups (FST=0.158), with high values of the Mc index (0.186-0.283), suggesting ancestral demographic decline events (between 11,910 to 23,820 years ago), associated with the Pleistocene climate changes. Conclusions: The study showed that P. remota contains a considerable genetic variation, which is spatially structured and associated with ancestral bottlenecks. Moreover, it is confirmed that P. catarinae is its synonym. The species has been able to survive and adapt to local environmental conditions. With this knowledge conservation strategies for the remaining populations of the species are proposed.

Resumen Antecedentes y Objetivos: El decremento y fragmentación de las poblaciones resulta en la pérdida de variación e incremento de la diferenciación genética. Pinus remota es una especie arbórea-arbustiva de distribución restringida con poblaciones dispersas y fragmentadas. Los objetivos del presente estudio fueron: evaluar los niveles de variación genética, la endogamia y el tamaño efectivo de las poblaciones, probar la hipótesis de la existencia de cuellos de botella asociados a la disminución de la variación genética de las poblaciones y analizar la estructura genética y su asociación con la distribución geográfica de las poblaciones. Métodos: El estudio se realizó en siete poblaciones representativas de su distribución natural en México, con muestras de acículas de 112 árboles analizadas con cinco microsatélites de núcleo. Los datos se evaluaron con parámetros de la genética de poblaciones y métodos de aproximación Bayesiana. Resultados clave: La heterocigosidad promedio esperada (He=0.557) fue más alta que la observada (Ho=0.375). Las poblaciones no se encuentran en equilibro Hardy-Weinberg, con una endogamia significativa (FIS=0.259) y tamaños efectivos reducidos (Ne entre 375-425); están estructuradas en tres grupos genéticos (FST=0.158), con valores altos del índice Mc (0.186-0.283), sugiriendo eventos de declinamiento demográfico ancestral (entre 11,910 y 23,820 años atrás), asociados con los cambios climáticos del Pleistoceno. Conclusiones: El estudio demuestra que P. remota contiene una variación genética considerable, pero estructurada espacialmente y asociada a cuellos de botella ancestrales. Además, se confirma que P. catarinae es su sinónimo. La especie ha sido capaz de subsistir y adaptarse a condiciones ambientales locales. Con este conocimiento se plantean estrategias para la conservación de las poblaciones remanentes de la especie.

https://doi.org/10.21829/abm128.2021.1890 24 descargas

13.

Distribution of Dendritic Cells in AIDS-Associated Oral Kaposi’s Sarcoma
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Cáceres, Cinthia Veronica Bardalez Lopez de

; Vargas, Pablo Agustin

; Sánchez-Romero, Celeste

; Bunn, Belinda K

; Heerden, Willie F. P. van

; Fonseca, Felipe Paiva

Brazilian Dental Journal

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Nov 2019, Volumen 30 Nº 6 Paginas 617 - 625

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste estudo foi determinar se a distribuição das células de Langerhans (CL) e das células dendríticas intersticiais (CDI) está alterada no sarcoma de Kaposi oral associado à AIDS quando comparado às lesões orais altamente vasculares HIV-negativas. 51 casos de sarcoma de Kaposi oral associado à AIDS e 20 de lesões orais altamente vasculares foram recuperados retrospectivamente. Todos os casos de sarcoma de Kaposi foram confirmados pela positividade para os anticorpos CD34 e HHV-8. Dados clínicos sobre sexo, idade e localização das lesões foram obtidos dos laudos histopatológicos. Foram realizadas imunoistoquímica contra CD207 (células dendríticas imaturas) e CD83 (células dendríticas maduras). As CL estavam presentes no epitélio enquanto as CDI estavam presentes no estroma. As células CD207+ predominaram no epitélio das lesões, enquanto as células CD83+ predominaram no estroma. O sarcoma de Kaposi teve uma contagem mais baixa de CD imaturas CD207+ (p = 0,02) e número aumentado de CDC CD207+ do que lesões orais altamente vasculares (p<0,001). Além disso, o sarcoma de Kaposi também mostrou um número aumentado de CDI CD83+ maduras do que lesões orais altamente vasculares (p<0,001). Houve alterações significativas na distribuição de CL e CDI no sarcoma de Kaposi associado à AIDS quando comparado às lesões orais vasculares HIV-negativas, sugerindo que alterações na distribuição das mesmas podem desempenhar um papel na patogênese do sarcoma de Kaposi.

Abstract The aim of this study was to determine if the distribution of Langerhans cells (LC) and interstitial dendritic cells (IDC) is altered in AIDS-associated oral Kaposi’s sarcoma when compared to HIV-negative highly vascular oral lesions. Fifty-one cases of AIDS-associated oral Kaposi’s sarcoma and 20 of highly vascular oral lesions were retrospectively retrieved. All cases of Kaposi’s sarcoma were confirmed with immunoreactions against CD34 and HHV-8. Clinical data regarding sex, age and lesions location were obtained from pathology reports. Immunohistochemistry against CD207 (immature dendritic cells) and CD83 (mature dendritic cells) were done. LC were in the epithelium and IDC in the stroma. CD207+ cells predominated in the epithelium of the lesions, whereas CD83+ cells predominated in their stromal compartment. Kaposi’s sarcoma had a lower CD207+ immature LC count (p=0.02) and an increased CD207+ IDC than highly vascular oral lesions (p<0.001). Moreover, Kaposi’s sarcoma also showed an increased number of mature CD83+ IDC than highly vascular oral lesions (p<0.001). There were significant alterations in the distribution of LC and IDC in AIDS-associated Kaposi’s sarcoma when compared to HIV-negative vascular oral lesions, suggesting that changes in their concentrations may play a role in the pathogenesis of Kaposi’s sarcoma.

https://doi.org/10.1590/0103-6440201902599 1103 descargas

14.

Oral squamous cell carcinoma: a clinicopathological study on 194 cases in northeastern Brazil. A cross-sectional retrospective study
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Leite, Amanda Almeida

; Leonel, Augusto César Leal da Silva

; Castro, Jurema Freire Lisboa de

; Carvalho, Elaine Judite de Amorim

; Vargas, Pablo Agustin

; Kowalski, Luiz Paulo

; Perez, Danyel Elias da Cruz

Sao Paulo Medical Journal

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Mar 2018, Volumen 136 Nº 2 Paginas 165 - 169

Resumen: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Only a few studies have evaluated the clinicopathological features of oral squamous cell carcinoma (SCC) in Brazil, and most were conducted in the most industrialized region of the country, i.e. the southeastern region. The aim of this study was to evaluate the clinicopathological features of this malignant neoplasm in northeastern Brazil. DESIGN AND SETTING: Retrospective study performed in an oral pathology laboratory in Recife, Brazil. METHODS: All cases of oral SCC that occurred between 2000 and 2015 were studied. Clinical data were recorded and histological slides were reviewed. Statistical analysis was performed using the chi-square test (P ≤ 0.05). RESULTS: A total of 194 cases were evaluated. The male-to-female ratio was 1.5:1. The mean age was 65.4 years, and only 6.6% of the cases occurred in patients younger than 41 years. Most tumors consisted of well-differentiated SCC (54.6%). CONCLUSIONS: The findings of this study highlight the higher prevalence of oral SCC among women and the increasing number of cases among young patients. Thus there is no specific risk group for oral SCC, as in the past. This fact needs to be taken into consideration in clinical routine care, so that apparently innocuous malignant lesions do not go unnoticed in these individuals.

https://doi.org/10.1590/1516-3180.2017.0293061217 1809 descargas

15.

BPI-fold (BPIF) containing/plunc protein expression in human fetal major and minor salivary glands
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ALVES, Daniel Berretta Moreira

; BINGLE, Lynne

; BINGLE, Colin David

; LOURENÇO, Silvia Vanessa

; SILVA, Andréia Aparecida

; PEREIRA, Débora Lima

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2017, Volumen 31 elocation e6

Resumen: En | Texto: En | PDF: En

Abstract The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second trimester and thus gain further insight into the function of these proteins. Early fetal heads, and major and minor salivary glands were collected retrospectively and glands were classified according to morphodifferentiation stage. Expression of BPI-fold containing proteins was localized through immunohistochemistry. BPIFA2, the major BPI-fold containing protein in adult salivary glands, was detected only in the laryngeal pharynx; the lack of staining in salivary glands suggested salivary expression is either very late in development or is only in adult tissues. Early expression of BPIFA1 was seen in the trachea and nasal cavity with salivary gland expression only seen in late morphodifferentiation stages. BPIFB1 was seen in early neural tissue and at later stages in submandibular and sublingual glands. BPIFA1 is significantly expressed in early fetal oral tissue but BPIFB1 has extremely limited expression and the major salivary BPIF protein (BPIFA2) is not produced in fetal development. Further studies, with more sensitive techniques, will confirm the expression pattern and enable a better understanding of embryonic BPIF protein function.

https://doi.org/10.1590/1807-3107bor-2017.vol31.0006 1879 descargas

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