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[SciELO Preprints] - The role of argumentation in language acquisition and the learning process of deaf children in bilingual schools
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Silva, Ana Clara Jardim da Vieira, Alessandra Jacqueline

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Fecha de publicación: 2024-02-01

Resumen: En Pt

According to Leitão (2007a; 2007b), argumentation is a privileged mechanism for the acquisition of language and knowledge, covering dimensions such as dialogical-discursive, dialectical, social and epistemic. This demonstrates the importance of developing it in the first years of school, especially in bilingual schools. The objective of this study is, therefore, to analyze the argumentative speeches produced by deaf children, seeking to identify the enunciative-discursive chains that generate argumentation and the epistemic changes generated by the effect of these argumentative speeches. For this, data collection was carried out in three bilingual schools (Portuguese-Libras), focused on the education of the deaf, covering a sample of 23 subjects, between 6 and 14 years old, where naturalistic situations were observed and provoked by playful workshops. Drawing on studies in argumentation (LEITÃO, 2006, 2007a; VIEIRA, 2015), multimodality (SOUSA; MÁXIMO, 2009; CAVALCANTE, 2016; 2011) and dialogism (VOLÓCHINOV; BAKHTIN, 2018; BAKHTIN, 2016), it was possible to conclude that argumentation stimulates discursive and linguistic movements (such as resuming statements, reading the context and syntactic organization) and multimodal movements (facial expression, social gestures, use of the body, etc.) that corroborate bimodal bilingual acquisition. Thus, argumentation contributes to the deaf child's entry into the language and favors the interactional process, which is extremely important for the formation of critical thinking and the expected language development.

Para Leitão (2007a; 2007b), a argumentação é um mecanismo privilegiado para a aquisição da linguagem e do conhecimento, perpassando dimensões como a dialógico-discursiva, dialética, social e epistêmica. Demonstra-se, assim, a importância de desenvolvê-la nos primeiros anos escolares, sobretudo em escolas bilíngues. O objetivo deste estudo é, portanto, analisar os discursos argumentativos produzidos por crianças surdas, buscando identificar os encadeamentos enunciativo-discursivos que geram a argumentação e as mudanças epistêmicas geradas pelo efeito desses discursos argumentativos. Para tanto, foram realizadas coletas de dados em três escolas bilíngues (Português-Libras), voltadas à educação de surdos, abarcando uma amostra de 23 sujeitos, entre 6 e 14 anos, onde foram observadas situações naturalísticas e provocadas por oficinas lúdicas. Amparando-se nos estudos em argumentação (LEITÃO, 2006, 2007a; VIEIRA, 2015), multimodalidade (SOUSA; MÁXIMO, 2009; CAVALCANTE, 2016; 2011) e dialogismo (VOLÓCHINOV; BAKHTIN, 2018; BAKHTIN, 2016), pôde-se concluir que a argumentação estimula movimentos discursivos e linguísticos (como retomada de enunciados, leitura do contexto e organização sintática) e multimodais (expressão facial, gestos sociais, uso do corpo, etc) que corroboram à aquisição bilíngue bimodal. Assim, a argumentação contribui à entrada da criança surda na língua e favorece o processo interacional, que é de extrema importância à formação do pensamento crítico e ao desenvolvimento linguageiro esperado.

https://doi.org/10.1590/SciELOPreprints.7972

Frequency of the DI*A, DI*B and Band 3 Memphis polymorphism among distinct groups in Brazil
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Kaliniczenko, Alessandra

; Martins, Juliana Oliveira

; Cruz, Bruno Ribeiro

; Chiba, Akemi Kuroda

; Vieira Filho, João Paulo Botelho

; Bordin, José Orlando

Hematology, Transfusion and Cell Therapy

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Jul 2023, Volumen 45 Supl. 2 Paginas S91 - S94

Resumen: En | Texto: En | PDF: En

ABSTRACT Introduction: The Band 3 is a red blood cell protein that carries the Dia and Dib antigens from the Diego blood system. The SLC4A1 gene encodes Band 3; Band 3 Memphis is a polymorphism of normal Band 3 and has two variants, but only the variant II carries the Dia antigen. Objectives: Describe the frequencies of the DI*A and DI*B alleles and the Band 3 Memphis among blood donors, sickle cell disease (SCD) patients and Amazonian Indians. Methods: A total of 427 blood samples were collected and separated into three groups: 206 unrelated blood donors, 90 patients with SCD and 131 Amazonian Indians. We performed DI*A/B, normal Band 3 and Band 3 Memphis genotyping, using the Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR–RFLP). Results: The frequency of the DI*A/DI*A genotype was 0.5% in blood donors and it was not found in other groups. The frequency of the DI*A/DI*B was higher in Amazonian Indians (33.6%) and the frequency of the DI*B/DI*B was highest in blood donors (92.2%). All 105 individuals tested were positive for the presence of normal Band 3 and of these individuals, only 5/105 (4.8%) presented the Band 3 Memphis mutation. Conclusion: We observed a higher frequency of the DI*B allele in blood donors and a low frequency of the DI*A/DI*A genotype in all groups studied. The Band 3 Memphis was found in a higher frequency in the blood donor group. Our findings highlight the importance of analyzing different population groups to gain a better understanding of the genetic association of blood group antigens.

https://doi.org/10.1016/j.htct.2022.03.002

Occult hepatitis B virus infection in patients with chronic liver disease of different etiology in a Brazilian referral center: comparison of two different hepatitis B virus deoxyribonucleic acid amplification protocols: a cross-sectional study
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Faria, Alessandra Coutinho de

; Correa, Bernardo Henrique Mendes

; Faria, Luciana Costa

; Vidigal, Paula Vieira Teixeira

; Xavier, Marcelo Antônio Pascoal

; Ferrari, Teresa Cristina Abreu

Sao Paulo Medical Journal

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2023, Volumen 141 Nº 3 elocation e2022147

Resumen: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Occult hepatitis B virus infection (OBI) is defined as the presence of hepatitis B virus (HBV) deoxyribonucleic acid (DNA) in the liver of individuals with undetectable hepatitis B virus surface antigen (HBsAg) in the serum. The actual prevalence of OBI and its clinical relevance are not yet fully understood. OBJECTIVE: To evaluate the prevalence of HBV DNA in liver biopsies of HBsAg-negative patients with chronic liver disease of different etiologies in a referral center in Brazil and compare two different HBV DNA amplification protocols to detect HBV. DESIGN AND SETTING: This cross-sectional observational study was conducted at the Liver Outpatient Clinic, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, between January 2016 and December 2019. METHODS: HBV DNA was investigated in 104 liver biopsy samples from individuals with chronic liver disease of different etiologies, in whom HBsAg was undetectable in serum by nested-polymerase chain reaction (nested-PCR), using two different protocols. RESULTS: OBI, diagnosed by detecting HBV DNA using both protocols, was detected in 6.7% of the 104 individuals investigated. Both protocols showed a good reliability. CONCLUSION: In addition to the differences in the prevalence of HBV infection in different regions, variations in the polymerase chain reaction technique used for HBV DNA amplification may be responsible for the large variations in the prevalence of OBI identified in different studies. There is a need for better standardization of the diagnostic methods used to diagnose this entity.

https://doi.org/10.1590/1516-3180.2022.0147.r1.12072022

Health-related quality of life in children with cerebral palsy associated with congenital Zika infection
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Marques, Fernanda Jordão Pinto

; Carvalho, Alessandra Lemos de

; Borigato, Eliana Valverde Magro

; Oliveira, Luiz Felipe Vieira de

; Duarte, Lenamaris Mendes Rocha

; Silva, Adriana Goncalves da

; Amarante, Claret Luiz Dias

; Pereira, Laura Jácome de Melo

; Tavares, Elise Ferreira

; Costa, Lilian Gleice de Sena da

; Alcântara, Carolina Alves Rezende

; Salinas, Andrea Nakamura

; Pinto, Fernanda de Lourdes da Cunha

; Alcântara, Gerliane Carvalho de

; Utsch, Fabiana

; Silva, Cinthia Ramos Diniz

; Reis, Dirlene Araujo dos

; Bessa, Wilerson Marques

; Dutra, Rafaela Christine

; Ventura, Paloma

; Oliveira, Tatiana Souza

Revista Paulista de Pediatria

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2023, Volumen 41 elocation e2022016

Resumen: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Objective: To describe the health-related quality of life (QOL) in children with cerebral palsy (CP) associated with congenital Zika infection. Methods: Cross-sectional study of a consecutive series of children, followed in a referral multicentric rehabilitation network in Brazil. We invited the caregivers to respond to the Brazilian version of the Caregiver Priorities & Child Health Index of Life with Disabilities (CPCHILDTM) questionnaire. Statistical analysis was performed with the Statistical Package for the Social Sciences (SPSS) 26.0™. We used absolute and relative frequencies for categorical variables and mean and standard deviation for continuous variables. Results: The sample consisted of 193 children, at mean age of 50.3±7.6 months. We observed a predominance of children with cerebral palsy (CP) with Gross Motor Function Classification System (GMFCS) level V (93.7%). Epilepsy (88.4%) was the most common comorbidity. CPCHILDTM mean scores were activities of daily living (ADL)/personal care 43.2±12.6; positioning, transferring and mobility 33.7±16.5; comfort and emotions 84.4±15.2; communication and social interaction (CoSI) 48.2±24.3; health 70.9±17.1; and overall quality of life (OQOL) 72.1±17.1. Total score was 54.8±11.3. Conclusions: Among children with cerebral palsy (CP) related to congenital Zika syndrome, the quality of life (QOL) scores were very similar to other populations with cerebral palsy (CP). The activities of positioning, transferring and mobility had the greatest impact on health-related quality of life (QOL). Rehabilitation strategies and public policies should prioritize aspects related to mobility for this population.

RESUMO Objetivo: Descrever a qualidade de vida relacionada à saúde em crianças com paralisia cerebral associada à infecção congênita pelo zika. Métodos: Estudo transversal de série consecutiva de casos de crianças acompanhadas em uma rede multicêntrica de reabilitação no Brasil. Convidamos o(s) cuidador(es) a responder à versão brasileira do Caregiver Priorities & Child Health Index of Life with Disabilities (CPCHILDTM). A análise estatística foi realizada com o pacote estatístico Statistical Package for the Social Sciences (SPSS) 26.0™. Para variáveis categóricas, foram utilizadas frequências absolutas e relativas e, para variáveis contínuas, média e desvio padrão. Resultados: Cento e noventa e três crianças, com idade média de 50,3±7,6 meses, foram incluídas. Observou-se predomínio de crianças com paralisia cerebral Gross Motor Function Classification System (GMFCS) nível V (93,7%). Epilepsia (88,4%) foi a comorbidade mais comum. As pontuações médias do CPCHILDTM foram: atividades de vida diária/cuidados pessoais 43,2±12,6; posicionamento, transferência e mobilidade 33,7±16,5; conforto e emoções 84,4±15,2; comunicação e interação social 48,2±24,3; saúde 70,9±17,1; e qualidade de vida geral 72,1±17,1. A pontuação total foi 54,8±11,3. Conclusões: Entre as crianças com paralisia cerebral relacionada à síndrome do zika congênita, as atividades de posicionamento, transferência e mobilidade tiveram maior impacto na qualidade de vida relacionada à saúde, semelhantemente a outras etiologias de paralisia cerebral. As estratégias de reabilitação e as políticas públicas devem priorizar os aspectos relacionados à mobilidade dessa população.

https://doi.org/10.1590/1984-0462/2023/41/2022016

Sensory analysis of goat cheese feed with sorghum silage levels in forage cactus based diets
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Sobral, Gilberto de Carvalho

; Oliveira, Juliana Silva de

; Saraiva, Carla Aparecida Soares

; Santos, Edson Mauro

; Vieira, Diego de Sousa

; Cruz, Antoniel Florencio da

; Torres Junior, Paulo da Cunha

; Albuquerque, Ítalo Reneu Rosas de

; Araújo, Alessandra Oliveira de

; Ribeiro, Neila Lidiany

Food Science and Technology

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2023, Volumen 43 elocation e90022

Resumen: En | Texto: En | PDF: En

Abstract: The objective of this study was to evaluate the quality of milk and cheese and sensory analysis of cheese from goats that received a diet with different levels of sorghum silage in the diet. Twenty Anglonubian dairy goats were used, with an average age of 2 years, average live weight of 43.7 kg, distributed in a completely randomized design, with five replications. Moisture (P=0.001), total solids (P=0.001), fat (p=0.001), TDE (P=0.006) and protein (P=0.003) of goat cheese showed a significant difference due to the inclusion of silage from goat cheese. sorghum in the diet. The sensory attributes soft appearance (P<.0001), look (P<.0001), salty taste (P<.0001) and smooth texture (P=0.0430) showed a significant difference depending on the level of sorghum silage added to the diet. of goats. In the PC analysis, it is observed that three main components were needed to represent the variation of 64.84% of the data. PC 1 determined 29% of the data variation and was represented by the attributes with the highest averages: attractive aroma (5.87) and global acceptability (7.74). The inclusion of up to 45% of sorghum silage in the diet of goats increased milk and cheese fat, which favored high scores for the attributes of softness and global acceptance.

https://doi.org/10.1590/fst.90022

Factors associated with macrophyte beta diversity in Caxiuanã Bay, located in the Eastern Amazon
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Vieira, Elaine Suzi Nascimento

; Bomfim, Francieli de Fátima

; Brito, Joás Silva

; Franco, Nayara Louback

; Nonato, Flávia Alessandra da Silva

; Michelan, Thaisa Sala

Acta Limnologica Brasiliensia

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2023, Volumen 35 elocation e32

Resumen: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Aim In this study, we investigated the beta diversity of macrophytes (total, turnover, and nestedness) in Caxiuanã Bay, localized in the Eastern Amazon. We also investigated the environmental factors determining the beta diversity and its components. Methods Macrophytes and physical-chemical variables (pH, water temperature, electrical conductivity, dissolved oxygen, and water turbidity) were sampled in 45 sites in 2017. Beta diversity was calculated based on Jaccard dissimilarity (using a presence/absence matrix) and partitioned in turnover and nestedness. We performed a Generalized Dissimilarity Modeling to analyze the influence of local (physical-chemical) and spatial factors (geographic distance) on total beta diversity and its components. Results A total of 16 macrophyte species were identified belonging to five morphological groups (free-floating, emergent, submerged, epiphytes, and rooted with floating leaves). The total beta diversity of macrophytes was 0.29, the turnover component had the highest contribution to total beta compared to nestedness. The beta total was influenced by geographic distance and conductivity, turnover by geographic distance and turbidity, and nestedness was explained by conductivity and pH. Conclusions In our study, physical-chemical factors influenced the structure of the macrophyte community, indicating that niche processes (deterministic) were acting and changing species composition. However, the spatial component and the low explanatory power of the models, especially for turnover, can also indicate the influence of stochastic processes such as ecological drift and/or limitations in dispersal. Our study provides new insights into the diversity patterns of macrophytes in Amazonian ecosystems, particularly in blackwater rivers. Our data also contribute to a better understanding of the processes that structure the species composition of macrophytes in these environments.

Resumo Objetivo Neste estudo, investigamos a diversidade beta de macrófitas aquáticas (total, turnover e aninhamento) na baía de Caxiuanã, localizada na Amazônia Oriental. Também investigamos os fatores ambientais que determinam a diversidade beta e seus componentes. Métodos As macrófitas e as variáveis físico-químicas (pH, temperatura da água, condutividade elétrica, oxigênio dissolvido e turbidez da água) foram amostradas em 45 pontos em 2017. A diversidade beta foi calculada usando a dissimilaridade de Jaccard (com matriz de presença/ausência das espécies) e particionada em turnover e aninhamento. Realizamos um Modelo Generalizado de Dissimilaridade para analisar a influência de fatores locais (físico-químicos) e espaciais (distância geográfica) na diversidade beta total e seus componentes. Resultados Um total de 16 espécies de macrófitas foi identificado pertencentes a cinco grupos morfológicos (flutuantes livres, emergentes, submersas, epífitas e enraizadas com folhas flutuantes). A diversidade beta total das macrófitas foi de 0,29, sendo que o componente turnover contribuiu mais para a diversidade beta total em comparação com o aninhamento. A diversidade beta total foi influenciada pela distância geográfica e condutividade, o turnover pela distância geográfica e turbidez, e o aninhamento foi explicado pela condutividade e pH. Conclusões Em nosso estudo, fatores físico-químicos influenciaram a estrutura da comunidade de macrófitas, indicando que processos de nicho (determinísticos) estavam atuando e alterando a composição das espécies. No entanto, o componente espacial e o baixo poder explicativo dos modelos, especialmente para o turnover, também podem indicar a influência de processos estocásticos, como a deriva genética e/ou limitações na dispersão. Nosso estudo traz novos insights sobre os padrões de diversidade das macrófitas em ecossistemas amazônicos, especialmente em rios de águas pretas. E auxiliam em uma melhor compreensão dos processos que estruturam a mudança na composição de espécies de macrófitas nesses ambientes.

https://doi.org/10.1590/s2179-975x5823

Construction and validation of nursing diagnoses for premature newborns
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Querido, Danielle Lemos

; Christoffel, Marialda Moreira

; Almeida, Viviane Saraiva de

; Esteves, Ana Paula Vieira dos Santos

; Menezes, Harlon França de

; Silva, Halene Cristina Dias de Armada e

; Camacho, Alessandra Conceição Leite Funchal

Revista da Escola de Enfermagem da USP

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2023, Volumen 57 elocation e20230167

Resumen: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: To build and validate nursing diagnoses based on the International Classification of Nursing Practice (ICNP®) for premature newborns admitted to the Neonatal Intensive Care Unit. Method: Methodological study based on the Brazilian method for developing subsets: use of specialized nursing language terms, construction of diagnostic statements and content validation of the statements by 40 specialist nurses. Those with a Content Validity Index (CVI) ≥ 0.80, organized according to Wanda Horta’s basic human needs theory, were considered valid. Results: 146 nursing diagnosis statements were constructed and 145 (93.3%) diagnoses were validated, with a predominance of the human need for cutaneous-mucosal integrity. Conclusion: The specificity of neonatal care is evident when these diagnoses are presented and validated in order to support nurses in their clinical reasoning and decision-making.

RESUMEN Objetivo: Construir y validar diagnósticos de enfermería basados en la Clasificación Internacional de la Práctica de Enfermería (CIPE®) para recién nacidos prematuros ingresados en la Unidad de Cuidados Intensivos Neonatales. Método: Estudio metodológico basado en el método brasileño de elaboración de subconjuntos: utilización de términos del lenguaje enfermero especializado, construcción de enunciados diagnósticos y validación de contenido de los enunciados por 40 enfermeros especialistas. Se consideraron válidos aquellos con Índice de Validez de Contenido (IVC) ≥ 0,80, organizados según las necesidades humanas básicas de Wanda Horta. Resultados: Se construyeron 146 enunciados de diagnóstico de enfermería y se validaron 145 (93,3%) diagnósticos, con predominio de la necesidad humana de integridad cutáneo-mucosa. Conclusión: La especificidad de los cuidados neonatales es evidente desde el momento en que estos diagnósticos son presentados y validados con el objetivo de subsidiar a las enfermeras en su razonamiento clínico y toma de decisiones.

RESUMO Objetivo: Construir e validar diagnósticos de enfermagem fundamentados na Classificação Internacional da Prática de Enfermagem (CIPE®) para recém-nascidos prematuros internados em Unidade de Terapia Intensiva Neonatal. Método: Estudo metodológico sustentado pelo método brasileiro para desenvolvimento de subconjuntos: utilização de termos da linguagem especializada de enfermagem, construção dos enunciados de diagnósticos e validação de conteúdo dos enunciados por 40 enfermeiros especialistas. Foram considerados válidos aqueles com Índice de Validade de Conteúdo (IVC) ≥ 0.80, organizados conforme à teoria das necessidades humanas básicas de Wanda Horta. Resultados: Foram construídos 146 enunciados de diagnósticos de enfermagem, e ao final foram validados 145 (93,3%) diagnósticos, com predominância na necessidade humana de integridade cutâneo-mucosa. Conclusão: A especificidade do cuidado neonatal fica evidente a partir do momento em que se apresentam tais diagnósticos, e que são validados com o objetivo de subsidiar o enfermeiro no raciocínio clínico e na tomada de decisão.

https://doi.org/10.1590/1980-220x-reeusp-2023-0167en

Botanical validation of Ecclinusa (Chrysophylloideae: Sapotaceae) from forest remnants using molecular analysis as a complementary method to morphological identification Chrysophylloideae (Chrysophylloideae Sapotaceae
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SILVA, Shirlene Cristina Brito da

; SANTOS, Gleiciane Rodrigues dos

; BATISTA, Telma Fátima Vieira

; FERREIRA, Gracialda Costa

; MORAES, Alessandra Jackeline Guedes de

; SENADO, Jéssy Anni Vilhena

; BEZERRA, Victor Fernando Galvão

; ARAÚJO, Dênmora Gomes de

; OHASHI, Selma Toyoko

; SILVA, Anderson Gonçalves da

Acta Amazonica

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2023, Volumen 53 Nº 4 Paginas 356 - 359

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO No contexto de um programa de restauração florestal em área de mineração na Amazônia oriental brasileira, o objetivo deste estudo foi identificar a espécie de abiu-seringarana (Ecclinusa sp.) em remanescentes florestais adjacentes à mina. Como a identificação de Ecclinusa com base apenas na morfologia externa é difícil, ela foi corroborada por análise molecular. Amostras de folhas de três árvores foram comparadas com Ecclinusa no acervo do herbário da Embrapa. O DNA extraído seguiu um protocolo CTAB modificado, e o sequenciamento foi com marcadores ITS. Tanto a identificação morfológica quanto o alinhamento das sequências obtidas com material do GenBank indicaram que os indivíduos pertencem a Ecclinusa guianensis, que é confirmada como a espécie que ocorre na área de mineração. brasileira abiuseringarana abiu seringarana sp. sp mina difícil molecular Embrapa modificado ITS guianensis

ABSTRACT In the context of a forest restoration program in a mining area in the eastern Brazilian Amazon, the objective of this study was to identify the species of trees of abiu-seringarana (Ecclinusa sp.) in forest remnants adjacent to the mine. As the identification of Ecclinusa based on external morphology alone is difficult, it was corroborated by molecular analysis. Leaf samples of three trees were compared with Ecclinusa in the Embrapa herbarium collection. DNA was extracted with a CTAB modified protocol for sequencing with ITS markers. Both the morphological identification and the alignment of the obtained sequences with material in GenBank indicated that the individuals belong to Ecclinusa guianensis, which is confirmed as the species occurring in the mining area. Amazon abiuseringarana abiu seringarana sp. sp mine difficult analysis collection markers guianensis

https://doi.org/10.1590/1809-4392202202992

Oral hyperpigmentation as an initial clinical aspect of hand foot syndrome
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Santos-Leite, Éder Gerardo dos

; Sacramento, Lorena Vieira

; Santana, Alessandra Monteiro

; Dantas, Juliana Borges de Lima

; Carrera, Manoela

; Martins, Gabriela Botelho

Brazilian Dental Journal

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Ago 2022, Volumen 33 Nº 4 Paginas 97 - 102

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A síndrome mão-pé (SMP) é um efeito adverso comum da terapia anticâncer. Sabe-se que causa sintomas dermatológicos, incluindo eritema acral e disestesia das palmas das mãos e solas dos pés, inchaço, dor, coceira e descamação. Alguns medicamentos como a capecitabina são conhecidos por desencadear essa condição. No entanto, a pigmentação da mucosa oral é um efeito adverso raro. Este trabalho tem como objetivo relatar um caso de hiperpigmentação da mucosa oral causada pela terapia com capecitabina antes do diagnóstico clínico de SMP. Mulher de 58 anos, com diagnóstico de carcinoma invasivo de ducto mamário, apresentou metástase no sistema nervoso central, fígado, pele e pulmão, em uso de capecitabina todos os dias por 14 ciclos. O exame oral revelou máculas negras multifocais no palato duro, mucosa bucal bilateral, mucosa gengival e dorso de língua. A hipótese clínica foi de hiperpigmentação da mucosa oral pelo uso de capecitabina e apenas o acompanhamento periódico foi necessário. A hiperpigmentação da mucosa oral pela capecitabina é uma consequência rara da terapia neoplásica e sua associação com SMP não é clara e pouco relatada. O relato desses eventos é importante para alertar as equipes de saúde oncológica sobre a tolerância individual à terapia com capecitabina.

Abstract Hand-foot syndrome (HFS) is a common adverse effect of anticancer therapy. It is known to cause dermatological symptoms including acral erythema and dysesthesia of the palms and soles of the feet, swelling, pain, itching, and scaling. Some drugs, like capecitabine, are known to trigger this condition. However, pigmentation of the oral mucosa is a rare adverse effect. This study aims to report a case of oral mucosa hyperpigmentation caused by capecitabine therapy before the clinical diagnosis of HFS. A 58-year-old female, diagnosed with invasive breast duct carcinoma, had the central nervous system, liver, skin, and lung metastasis, using capecitabine every day for 14 cycles. Oral examination revealed multifocal black macules on the hard palate, bilateral buccal mucosa, gingival mucosa, and dorsum of the tongue. The clinical hypothesis was oral mucosa hyperpigmentation by capecitabine use and only periodic follow-up was necessary. Hyperpigmentation of oral mucosa by capecitabine is a rare consequence of neoplastic therapy and your association with HFS is unclear, and poorly reported. The report of these events is important to alert oncology health teams about the individual tolerance to capecitabine therapy.

https://doi.org/10.1590/0103-6440202204711

10.

DETERMINING FACTORS OF ENTREPRENEURIAL INTENTION: A STUDY WITH ENTREPRENEURS AND POTENTIAL ENTREPRENEURS OF THE STATE OF ACRE
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Brito, Bárbara Alessandra Vieira de

; Kuniyoshi, Márcio Shoiti

; Cappellozza, Alexandre

; Vieira, Almir Martins

Revista de Administração da UFSM

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Jun 2022, Volumen 15 Nº 2 Paginas 290 - 310

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo - Analisar, sob a ótica da Teoria do Comportamento Planejado, os fatores determinantes da intenção empreendedora de empreendedores e potenciais empreendedores do Acre. Design / metodologia / abordagem - A pesquisa abrangeu egressos do Seminário Empretec (SEBRAE), utilizando a metodologia quantitativa de Modelagem em Equações Estruturais pelos Mínimos Quadrados Parciais (Partial Least Square Structural Equation Modeling - PLS-SEM). Resultados - Constatou-se que a Atitude Face ao Comportamento é o construto que mais influencia positivamente a Intenção Empreendedora, seguida dos construtos Normas Subjetivas e Percepção de Controle. Limitações / implicações da pesquisa As limitações acerca do estudo realizado dizem respeito à população, pois o rol de participantes contempla apenas egressos do Seminário Empretec, como também ao fato de não ter sido considerado se os indivíduos estavam temporalmente próximos ao evento desencadeador. Implicações práticas - Destaca-se a importância que alguns preditores têm sobre a intenção empreendedora. Merece registro também o estímulo ao empreendedorismo para fortalecer a economia, direcionando as ações e políticas voltadas à criação e ao desenvolvimento de empresas do estado do Acre. Originalidade / relevância - Em termos de contexto local (estado do Acre), a pesquisa é inédita; e, por ser a intenção empreendedora considerada como a primeira etapa no processo de descoberta e exploração de oportunidades, é parte fundamental para compreensão do empreendedorismo e da intenção empreendedora.

ABSTRACT Objectives - this article aimed to analyze, from the perspective of the Theory of Planned Behavior, the determining factors of the entrepreneurial intention of entrepreneurs and potential entrepreneurs of Acre. Design / Methodology / Approach - The research covered graduates of the Empretec Seminar (SEBRAE), using the quantitative methodology of Structural Equation Modeling by Partial Least Square Structural Equation Modeling (PLS-SEM). Results - Results showed that Attitude Towards Behavior is the construct that most positively influences the entrepreneurial intention, followed by the constructs of the subjective norms and the perception of control. Limitations / implications of the research The limitations of the study are related to the population because the list of participants includes only graduates of the Empretec Seminar, as well as the fact that it was not considered whether the individuals were temporally close to the triggering event. Practical implications - Entrepreneurial intention is considered as the first step in the process of discovering and exploiting opportunities, which makes it a fundamental part of the understanding of entrepreneurship. The study contributes in diminishing the gap of theoretical and empirical studies on this subject in the Brazilian scenario. Originality / value - The hypothesis that the need for achievement positively influences the entrepreneurial intention has not been accepted, which can occur due to the fact that the psychological characteristics of the entrepreneurs can undergo changes as the entrepreneur moves away from the motivating event of entrepreneurship.

https://doi.org/10.5902/1983465968764

11.

Reliability of quantitative sensory testing on myofascial trigger points in the upper trapezius muscle of individuals with chronic neck pain
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Dibai Filho, Almir Vieira

; Oliveira, Alessandra Kelly de

; Oliveira, Matheus Pereira

; Barros, Marília Artese

; Bevilaqua-Grossi, Débora

; Guirro, Rinaldo Roberto de Jesus

Revista da Associação Médica Brasileira

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Ene 2022, Volumen 68 Nº 1 Paginas 56 - 60

Resumen: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: The objective of this study was to measure the intra- and inter-rater reliability of the quantitative sensory testing for measuring the thermal pain threshold on myofascial trigger points in the upper trapezius muscle of individuals with chronic neck pain. METHODS: Thirty female participants were included, aged between 18 and 45 years and with bilateral myofascial trigger points, active and centrally located in the upper trapezius muscle. Two measurements with quantitative sensory testing were performed by each examiner at an interval of 1 week between them. RESULTS: We observed substantial reliability for the intra-rater analysis (intraclass correlation coefficient ranging between 0.876 and 0.896) and excellent reliability for the inter-rater analysis (intraclass correlation coefficient ranging between 0.917 and 0.954). CONCLUSION: The measurement of the thermal pain threshold on myofascial trigger points in individuals with chronic neck pain has acceptable reliability values, supporting the use of the quantitative sensory testing in the research setting and the clinical environment.

https://doi.org/10.1590/1806-9282.20210762

12.

Guidelines on COVID-19 vaccination in patients with immune-mediated rheumatic diseases: a Brazilian Society of Rheumatology task force
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Tavares, Anna Carolina Faria Moreira Gomes

; Melo, Ana Karla Guedes de

; Cruz, Vítor Alves

; Souza, Viviane Angelina de

; Carvalho, Joana Starling de

; Machado, Ketty Lysie Libardi Lira

; Valadares, Lilian David de Azevedo

; Reis Neto, Edgard Torres dos

; Rezende, Rodrigo Poubel Vieira de

; Guimarães, Maria Fernanda Brandão de Resende

; Ferreira, Gilda Aparecida

; Braz, Alessandra de Sousa

; Vieira, Rejane Maria Rodrigues de Abreu

; Pinheiro, Marcelo de Medeiros

; Ribeiro, Sandra Lúcia Euzébio

; Bica, Blanca Elena Gomes Rios

; Baptista, Kátia Lino

; Costa, Izaias Pereira da

; Marques, Claudia Diniz Lopes

; Lopes, Maria Lúcia Lemos

; Martinez, José Eduardo

; Giorgi, Rina Dalva Neubarth

; Mota, Lícia Maria Henrique da

; Loures, Marcos Antônio Araújo da Rocha

; Paiva, Eduardo dos Santos

; Monticielo, Odirlei André

; Xavier, Ricardo Machado

; Kakehasi, Adriana Maria

; Pileggi, Gecilmara Cristina Salviato

Advances in Rheumatology

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2022, Volumen 62 elocation 3

Resumen: En | Texto: En | PDF: En

Abstract Objective: To provide guidelines on the coronavirus disease 2019 (COVID-19) vaccination in patients with immune-mediated rheumatic diseases (IMRD) to rheumatologists considering specific scenarios of the daily practice based on the shared-making decision (SMD) process. Methods: A task force was constituted by 24 rheumatologists (panel members), with clinical and research expertise in immunizations and infectious diseases in immunocompromised patients, endorsed by the Brazilian Society of Rheumatology (BSR), to develop guidelines for COVID-19 vaccination in patients with IMRD. A consensus was built through the Delphi method and involved four rounds of anonymous voting, where five options were used to determine the level of agreement (LOA), based on the Likert Scale: (1) strongly disagree; (2) disagree, (3) neither agree nor disagree (neutral); (4) agree; and (5) strongly agree. Nineteen questions were addressed and discussed via teleconference to formulate the answers. In order to identify the relevant data on COVID-19 vaccines, a search with standardized descriptors and synonyms was performed on September 10th, 2021, of the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and LILACS to identify studies of interest. We used the Newcastle–Ottawa Scale to assess the quality of nonrandomized studies. Results: All the nineteen questions-answers (Q&A) were approved by the BSR Task Force with more than 80% of panelists voting options 4—agree—and 5—strongly agree—, and a consensus was reached. These Guidelines were focused in SMD on the most appropriate timing for IMRD patients to get vaccinated to reach the adequate covid-19 vaccination response. Conclusion: These guidelines were developed by a BSR Task Force with a high LOA among panelists, based on the literature review of published studies and expert opinion for COVID-19 vaccination in IMRD patients. Noteworthy, in the pandemic period, up to the time of the review and the consensus process for this document, high-quality evidence was scarce. Thus, it is not a substitute for clinical judgment.

https://doi.org/10.1186/s42358-022-00234-7

13.

Site characterization for the design of thermoactive geostructures
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Vieira, Ana

; Alberdi-Pagola, Maria

; Barla, Marco

; Christodoulides, Paul

; Florides, Georgios

; Insana, Alessandra

; Javed, Saqib

; Maranha, João

; Milenic, Dejan

; Prodan, Iulia

; Salciarini, Diana

Soils and Rocks

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2022, Volumen 45 Nº 1 elocation e2022001022

Resumen: En | Texto: En | PDF: En

Abstract This paper addresses the topic of site characterization for the design of Shallow Geothermal Energy (SGE) systems, namely of thermoactive geostructures, which are geotechnical structures, such as piles, retaining walls and tunnel linings, also used as heat exchangers as part of closed-loop SGE systems. Such solutions, being increasingly adopted for buildings’ and infrastructures’ heating and/or cooling, are considered sustainable and cost effective. For the design of the primary circuit of the SGE system, which is embedded within the superficial soil layers, a comprehensive knowledge of the ground condition at the site is mandatory. This includes the evaluation of the energy features and whether the system can provide the required energy needs during the operational period, as well as the verification of the structural and geotechnical safety and functionality requirements. The site characterization for SGE systems involves different stages, from desk studies to detailed characterization, including in-situ trials, laboratory testing of undisturbed soil samples and the study of possible interferences. The specific aspects that will be addressed are: (i) the assessment of the site undisturbed ground temperature and its hydrogeological features; (ii) the thermal and thermomechanical characterization of the different soil layers; (iii) the investigation of the ground-heat exchanger thermal resistance; (iv) the collection of information related to the environmental constraints and to potential interferences among multiple users, which are related to the service life of the structure. The overall aim is to ensure a proper design of the SGE system for guaranteeing its sustainability in the long term.

https://doi.org/10.28927/sr.2022.001022

14.

Chemical composition of forage watermelon fruit at different maturity stage or storage length
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Azeredo, Alessandra Bezerra de

; Silva, Ana Paula Ribeiro da

; Matias, Alex Gomes da Silva

; Silva, Valterlina Moreira da

; Correia, Airton Alves Vieira

; Voltolini, Tadeu Vinhas

Acta Scientiarum. Animal Sciences

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2022, Volumen 44 elocation e53624

Resumen: En | Texto: En | PDF: En

ABSTRACT. This study aimed to assess the chemical responses of forage watermelon fruit at different maturity stages or storage lengths, performing two experimental tests. In the first test, four maturity stages were assessed: 30, 45, 60, and 75 days after anthesis, with four replicates. In the second test, fruits were maintained under three storage lengths: T1D (harvest day), T3M (3 months after harvest), and T6M (6 months after harvest), with eight replicates. Experimental design was completely randomized in both experimental tests. Fruit maturity stage did not affect crude protein, total carbohydrate, neutral detergent fiber, in vitro dry matter digestibility (IVDMD), pulp firmness, soluble solids content and total pectin content, but increased acid detergent fiber content from 45 days after anthesis. Storage length up to six months after harvest increased ash, crude protein and IVDMD, and reduced the content of soluble solids. Forage watermelon fruit can be harvested from 30 to 75 days after anthesis equivalent to 75 - 120 days after planting, and they can be stored under tree shade up to 6 months after harvest.

https://doi.org/10.4025/actascianimsci.v44i1.53624

15.

Is social isolation during the COVID-19 pandemic a risk factor for depression?
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Moura, Adaene Alves Machado de

; Bassoli, Igor Roberto

; Silveira, Belisa Vieira da

; Diehl, Alessandra

; Santos, Manoel Antônio dos

; Santos, Ronildo Alves dos

; Wagstaff, Christopher

; Pillon, Sandra Cristina

Revista Brasileira de Enfermagem

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2022, Volumen 75 Supl. 1 elocation e20210594

Resumen: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Avaliar os fatores associados à depressão entre estudantes e profissionais de nível superior durante o pico da pandemia de COVID-19. Método: estudo quantitativo com delineamento transversal. Participaram 550 estudantes e profissionais. Os dados foram coletados por meio de um questionário digital, que incluía o Patient Health Questionnaire-9 para avaliação de sintomas depressivos. Resultados: Os fatores relacionados à depressão e os desfechos do isolamento social foram significantemente associados ao sexo feminino (n=149; 37,8%; Odds Ratio OR=2,0), raça branca (n=127; 37,2%; OR=1,60), jovens (n=130; 39,4%; OR=2,0), sem religião (n=70; 40,2%; OR=1,64), com problemas financeiros (n=80; 53,0%; OR=2,40) e familiares (n=98; 47,3%; OR=1,77), que sofreram violência durante a quarentena (n=28; 58,3%; OR=2,33), aumentaram o uso de drogas ilícitas (n=16; 59,3%; OR=2,69), consumiram sedativos sem prescrição médica (n=75; 54,0%; OR=2,94), vivenciaram relacionamentos conflituosos (n=33; 54,1%;OR=2,14), perderam o emprego na pandemia (n=32; 59,3%; OR=1,99) e apresentaram sintomas de ansiedade relacionada à COVID-19 (n=155; 45,2%; OR=3,91). Conclusão: há uma relação significativa entre vulnerabilidade e adoção de comportamentos de risco durante o isolamento social imposto pela pandemia com sintomas depressivos. Sugerimos que os profissionais de saúde estejam atentos para a necessidade de ajustar suas intervenções psicossociais ao promoverem estratégias para mitigar os efeitos e riscos à saúde mental.

ABSTRACT Objective: To assess factors associated with depression among higher education students and professionals during the peak of the COVID-19 pandemic. Method: quantitative study with a cross-sectional design. 550 students and professionals participated. The data were collected by means of a digital questionnaire that included Patient Health Questionnaire-9 to assess depressive symptoms. Results: The factors related to depression and social isolation outcomes were significantly associated with the female gender (n= 149; 37,8%; Odds Ratio OR=2,0), white (n=127; 37,2%; OR=1,60), young people (n=130; 39,4%; OR=2,0), without religion (n=70; 40,2%; OR=1,64), with financial problems (n=80; 53,0%; OR=2,40) and family problems (n=98; 47,3%; OR=1,77); who suffered violence during the quarantine (n=28; 58,3%; OR=2,33), increased the use of illicit drugs (n=16; 59,3%; OR=2,69), used sedatives without a medical prescription (n=75; 54,0%; OR=2,94), lived in conflicting relationships (n=33; 54,1%;OR=2,14), lost their job during the pandemic (n=32; 59,3%; OR=1,99) and presented symptoms of anxiety related to COVID-19 (n=155; 45,2%; OR=3,91). Conclusion: there is a meaningful relationship between vulnerability and adopting risk behaviors during the pandemic-imposed social isolation with depressive symptoms. We suggest that health professionals be attentive to the need to adjust their psychosocial interventions when promoting strategies when promoting strategies to mitigate the effects and risks to mental health.

RESUMEN Objetivo: Evaluar los factores asociados a la depresión entre estudiantes y profesionales de nivel superior durante el pico de la pandemia de COVID-19. Método: estudio cuantitativo con delineamiento transversal. Participaron 550 estudiantes y profesionales. Los datos fueron obtenidos por medio de un cuestionario digital, que incluía el Patient Health Questionnaire-9 para evaluación de síntomas depresivos. Resultados: Los factores relacionados a la depresión y los resultados del aislamiento social fueron significativamente asociados al sexo femenino (n= 149; 37,8%; Odds Ratio OR=2,0), raza blanca (n=127; 37,2%; OR=1,60), jóvenes (n=130; 39,4%; OR=2,0), sin religión (n=70; 40,2%; OR=1,64), con problemas financieros (n=80; 53,0%; OR=2,40) y familiares (n=98; 47,3%; OR=1,77); que sufrieron violencia durante la cuarentena (n=28; 58,3%; OR=2,33), aumentaron el uso de drogas ilícitas (n=16; 59,3%; OR=2,69), consumieron sedativos sin prescripción médica (n=75; 54,0%; OR=2,94), vivieron relaciones conflictivas (n=33; 54,1%;OR=2,14), perdieron el empleo en la pandemia (n=32; 59,3%; OR=1,99) y presentaron síntomas de ansiedad relacionado al COVID-19(n=155; 45,2%; OR=3,91). Conclusión: Hay una relación significativa entre vulnerabilidad y adopción de comportamientos de riesgo durante el aislamiento social impuesto por la pandemia con síntomas depresivos. Sugerimos que los profesionales de la salud estén atentos ante la necesidad de ajustar sus intervenciones psicosociales al promover estrategias para mitigar los efectos y riesgos para la salud mental.

https://doi.org/10.1590/0034-7167-2021-0594

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