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ABSTRACT: European market regulates that poultry electronarcosis stunning in abattoirs must be performed with a minimal required current (mA per animal) and correlative frequency (Hz), to promote animal welfare and meat quality. In this way, Brazilian abattoirs must adjust the stunning parameters so that they can meet the requirements of that market. This study evaluated the effect of stunning parameters using frequency and duty cycle variables. For this, nine treatments were performed, whose results showed that the analyzed frequencies (700, 1100, and 1500 Hz) had a higher incidence of indicators of animal welfare (AW). Thus, stunning had low efficiency in AW terms. However, the 25% and 40% duty cycles had the best stunning efficiency. There was no significant difference (P > 0.05) for pH 24 h, bruises, and drip loss. Color and pH 2 h were significantly affected (P < 0.05). The shear force was higher in birds subjected to higher frequencies and interaction between 1500 Hz and 15% and 25% duty cycles. Water-holding capacity was lower at 1100 Hz and in the 25% duty cycle interactions. The treatments affected the evaluated indicators, except for the 40% duty cycle, which had a positive influence. Therefore, the duty cycle applicability must be elucidated due to its direct influence on stunning efficiency.

RESUMO: O mercado europeu regulamenta que a insensibilização de aves por eletronarcose nos abatedouros deva acontecer com uma corrente mínima necessária (mA por animal) e frequência correlata (Hz), com corrente e frequência alta. O intuito é promover o bem estar animal e qualidade de carne. Desta forma, os abatedouros brasileiros devem ajustar os parâmetros de insensibilização para que possam atender este mercado. O objetivo do trabalho foi avaliar o efeito dos parâmetros de insensibilização usando as variáveis frequência e duty cycle. Foram realizados nove ensaios. Os resultados demostraram que as frequências avaliadas (700 Hz, 1100 Hz e 1500 Hz) apresentaram maior incidência nos indicadores de Bem Estar Animal (BEA). Assim, houve baixa eficiência na insensibilização das aves para este fator. Entretanto, o duty cycle 25% e 40% promoveu a melhor eficiência na insensibilização das aves. Não foi observada diferença significativa (P > 0,05) para pH 24h, hematomas e a perda por gotejamento. A cor e o pH 2h foram afetados significativamente (P < 0,05) nos ensaios avaliados. A força de cisalhamento foi maior nas frequências mais altas e na interação da frequência de 1500 Hz com o duty cycle de 15% e 25% A capacidade de retenção de água foi menor na frequência de 1100 Hz, e na interação duty cycle 25%. Os ensaios estudados apresentaram comprometimento dos indicadores avaliados, exceto a variável duty cycle a 40%, que demonstrou influência positiva nos indicadores avaliados. Portanto, a aplicabilidade do duty cycle deve ser elucidada devido a sua influência direta na eficiência da insensibilização.

https://doi.org/10.1590/0103-8478cr20220668

Consensus on the therapeutic management of atopic dermatitis ‒ Brazilian Society of Dermatology: an update on phototherapy and systemic therapy using e-Delphi technique
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Orfali, Raquel Leao

; Lorenzini, Daniel

; Bressan, Aline

; Tanaka, Anber Ancel

; Cerqueira, Ana Maria Mósca de

; Hirayama, André da Silva

; Ramos, Andréa Machado Coelho

; Proença, Carolina Contin

; Silva, Claudia Marcia de Resende

; Laczynski, Cristina Marta Maria

; Carneiro, Francisca Regina

; Duarte, Gleison

; Hans Filho, Gunter

; Gonçalves, Heitor de Sá

; Melo, Ligia Pessoa de

; Azulay-Abulafia, Luna

; Weber, Magda Blessmann

; Rivitti-Machado, Maria Cecília

; Zaniboni, Mariana Colombini

; Ogawa, Marília

; Pires, Mario Cezar

; Ianhez, Mayra

; Felix, Paulo Antonio Oldani

; Bonamigo, Renan

; Takaoka, Roberto

; Lazzarini, Rosana

; Cestari, Silmara

; Mayor, Silvia Assumpção Soutto

; Cestari, Tania

; Oliveira, Zilda Najjar Prado de

; Spuls, Phyllis I.

; Gerbens, Louise A.A.

; Aoki, Valeria

Anais Brasileiros de Dermatologia

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2023, Volumen 98 Nº 6 Paginas 814 - 836

Resumen: En | Texto: En | PDF: En

Abstract This publication is an update of the “Consensus on the therapeutic management of atopic dermatitis - Brazilian Society of Dermatology” published in 2019, considering the novel, targeted-oriented systemic therapies for atopic dermatitis. The initial recommendations of the current consensus for systemic treatment of patients with atopic dermatitis were based on a recent review of scientific published data and a consensus was reached after voting. The Brazilian Society of Dermatology invited 31 experts from all regions of Brazil and 2 international experts on atopic dermatitis who fully contributed to the process. The methods included an e-Delphi study to avoid bias, a literature search and a final consensus meeting. The authors added novel approved drugs in Brazil and the indication for phototherapy and systemic therapy for AD. The therapeutical response to systemic treatment is hereby reported in a suitable form for clinical practice and is also part of this updated manuscript.

https://doi.org/10.1016/j.abd.2023.04.003

Alteration of the organic matter fractions in soil cultivated with sugarcane in the Cerrado-Amazon transition zone
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Ferreira, Esvanio Édipo da Silva

; Nascimento, Elisamara Caldeira do

; Silva, Adeilson Nascimento da

; Soares, Keller Regina

; Weber, Oscarlina Lúcia dos Santos

Pesquisa Agropecuária Tropical

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2022, Volumen 52 elocation e72513

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O uso de resíduos agroindustriais, como a vinhaça, pode alterar as características químicas e físicas do solo. Objetivou-se avaliar o carbono orgânico total e o nitrogênio total de um solo e a distribuição de carbono e nitrogênio nas frações granulométricas areia e argila, em três sistemas de manejo (com e sem aplicação de vinhaça e com uso de queimada para a colheita, em comparação à cobertura vegetal de foresta primária/mata nativa), quanto ao modo de colheita e adubação da cana-de-açúcar, na região Centro-Oeste do Brasil. O uso de resíduos orgânicos no sistema de produção da canade-açúcar pode proporcionar, mesmo em curto período, conservação e melhoria da qualidade do solo pela adição e manutenção de carbono orgânico. O uso de vinhaça favorece o aumento do carbono orgânico total e do nitrogênio total no solo, na fração argila, em todas profundidades avaliadas. O sistema com queima resulta em teores de carbono total menores na fração areia, em comparação à fração argila, e, mesmo com a colheita da cana após a queima, a matéria orgânica mais recalcitrante está associada à fração argila.

ABSTRACT The use of agroindustrial wastes, such as vinasse, may alter the soil chemical and physical characteristics. This study aimed to evaluate the total organic carbon and total nitrogen in a soil and the distribution of carbon and nitrogen in the sand and clay granulometric fractions, in three management systems (with and without vinasse application and with burning for harvest, in comparison with primary/native forest coverage), regarding fertilization and harvesting of sugarcane, in the Midwest region of Brazil. The use of organic wastes in the sugarcane production system may promote, even in a short time frame, conservation and improvement of the soil quality by the addition and maintenance of organic carbon. The use of vinasse favors the increase of the total organic carbon and total nitrogen in the soil, in the clay fraction, at all evaluated depths. The system with burning results in lower total carbon levels in the sand fraction, in comparison with the clay fraction, and, even with the sugarcane harvest employing burning, the most recalcitrant organic matter is associated with the clay fraction.

https://doi.org/10.1590/1983-40632022v5272513

Effect of the Brazilian Cardioprotective Nutritional Program on the Quality of Life of Atherosclerotic Disease Patients
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Martins, Patrícia Regina Thomé

; Moreira, Annie Seixas Bello

; Santos, Elisa Maia dos

; Rodrigues Júnior, Luiz Fernando

; Weber, Bernadete

International Journal of Cardiovascular Sciences

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Dic 2021, Volumen 34 Nº 6 Paginas 620 - 631

Resumen: En | Texto: En | PDF: En

Abstract Background Cardiovascular diseases (CVD) accounted for 27% of deaths in Brazil in 2017. Most of the recorded deaths caused by CVD would be preventable if patients controlled risk factors including inadequate diet. The Brazilian Cardioprotective Nutritional Program (Dica Br) adapted the Mediterranean diet pattern to Brazilian typical foods and evaluated the effectiveness of a nutritional program based on cardioprotective foods on cardiovascular events and death of patients with cardiovascular diseases. Objectives To evaluate the effect of Dica Br on the QoL of patients with atherosclerotic disease from two health centers in the city of Rio de Janeiro. Method Randomized clinical trial with 273 participants of both sexes, over 45 years old, followed for four years. The intervention group (IG) received individualized dietary prescription, educational program, individual and group consultations, and phone calls. The control group (CG) received general dietary guidance. The SF-36 was used to assess QoL. The Student’s t-test and the Mann-Whitney test was used to compare means between the groups. The mixed model test was used to compare the course of variables over time between the groups. Statistical significance was set at 5%. Result Most patients were male, with an average age of 64.2 ± 8.2 years in the IG and 65±9.5 years in the CG. Most were physically inactive, overweight, and had incomplete elementary school. The most prevalent comorbidity was systemic arterial hypertension, followed by dyslipidemia. QoL improved in both groups at four years. Waist circumference decreased in both groups over time, and low-density lipoprotein cholesterol (LDL-C) levels decreased in the IG but not in the CG after four years of follow-up. Conclusion The cardioprotective diet was effective in reducing LDL-C in the IG, and an improvement in QoL was observed in both intervention and control groups.

https://doi.org/10.36660/ijcs.20200087

Do Império à cidade multiétnica: austríacos no sul do Brasil
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Weber, Regina

Revista Brasileira de Estudos de População

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2021, Volumen 38 elocation e0178

Resumen: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Este artigo enfoca as circunstâncias que configuraram uma identidade específica a imigrantes identificados como “austríacos”. O lócus principal da pesquisa é um núcleo de povoamento no interior do Rio Grande do Sul, reunindo dados que vão do final do século XIX ao final do século XX, período que contempla, em termos internacionais, a existência, ainda que a poucas décadas do seu final, do Império Austro-Húngaro e, em nível local, investimentos recentes no memorialismo étnico. Está sendo dado destaque aos agentes que realizam conexões entre mundos e tempos diferentes e aos modos pelos quais são operacionalizadas as representações do passado.

Abstract This article focuses the circumstances which shaped the creation of a specific identity forimmigrants recognized as ‘Austrians’ in the South of Brazil. The main locus of this research is a small settlement in Rio Grande do Sul’s inland, as we collected data from the end of the nineteenth century to the end of the twentiethcentury, comprising the finalyears of the Austro-Hungarian Empire, and locally witnessing late investment in ethnic memorialism. We highlight the agents who accomplish connections between distinct worlds and times, as well as the ways in which past representations are put into action.

Resumen Este artículo se centra en las circunstancias que dieron forma a una identidad específica para los inmigrantes identificados como austríacos. El lugar principal de la investigación es un asentamiento en el interior de Río Grande del Sur y fueron recolectados datos que van desde finales del siglo XIX hasta finales del siglo XX, un período que contempla, en términos internacionales, la existencia, aunque unas pocas décadas a partir de su fin, del Imperio austrohúngaro y, en lo local, las recientes inversiones en el memorialismo étnico. Se hace hincapié en los agentes que conectan diferentes mundos y tiempos y en las formas en las que las representaciones del pasado se hacen operativas.

https://doi.org/10.20947/s0102-3098a0178 33 descargas

COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves

; Ximenez, João Paulo Bianchi

; Seiva, Fábio Rodrigues Ferreira

; Panis, Carolina

; Bezerra, Rafael dos Santos

; Ferrasa, Adriano

; Cecchini, Alessandra Lourenço

; Medeiros, Alexandra Ivo de

; Almeida, Ana Marisa Fusco

; Ramão, Anelisa

; Boldt, Angelica Beate Winter

; Moya, Carla Fredrichsen

; Chin, Chung Man

; Paula, Daniel de

; Rech, Daniel

; Gradia, Daniela Fiori

; Malheiros, Danielle

; Venturini, Danielle

; Tavares, Eliandro Reis

; Carraro, Emerson

; Ribeiro, Enilze Maria de Souza Fonseca

; Pereira, Evani Marques

; Tuon, Felipe Francisco

; Follador, Franciele Aní Caovilla

; Fernandes, Glaura Scantamburlo Alves

; Volpato, Hélito

; Cólus, Ilce Mara de Syllos

; Oliveira, Jaqueline Carvalho de

; Rodrigues, Jean Henrique da Silva

; Santos, Jean Leandro dos

; Visentainer, Jeane Eliete Laguila

; Brandi, Juliana Cristina

; Serpeloni, Juliana Mara

; Bonini, Juliana Sartori

; Oliveira, Karen Brajão de

; Fiorentin, Karine

; Lucio, Léia Carolina

; Faccin-Galhardi, Ligia Carla

; Ferreto, Lirane Elize Defante

; Lioni, Lucy Megumi Yamauchi

; Consolaro, Marcia Edilaine Lopes

; Vicari, Marcelo Ricardo

; Arbex, Marcos Abdo

; Pileggi, Marcos

; Watanabe, Maria Angelica Ehara

; Costa, Maria Antônia Ramos

; Giannini, Maria José S. Mendes

; Amarante, Marla Karine

; Khalil, Najeh Maissar

; Lima Neto, Quirino Alves de

; Herai, Roberto H.

; Guembarovski, Roberta Losi

; Shinsato, Rogério N.

; Mainardes, Rubiana Mara

; Giuliatti, Silvana

; Yamada-Ogatta, Sueli Fumie

; Gerber, Viviane Knuppel de Quadros

; Pavanelli, Wander Rogério

; Silva, Weber Claudio da

; Petzl-Erler, Maria Luiza

; Valente, Valeria

; Soares, Christiane Pienna

; Cavalli, Luciane Regina

; Silva Jr, Wilson Araujo

Genetics and Molecular Biology

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2021, Volumen 44 Nº 1 elocation e20200452

Resumen: En | Texto: En | PDF: En

Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.

https://doi.org/10.1590/1678-4685-gmb-2020-0452

Phytobiotic effect of Marrubium vulgare and Leonurus sibiricus on productive performance of griller-type broilers
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Schlemper, Valfredo

; Molinetti, Wellinton Thiago

; Prando, Diogo Gasparin

; Weber, Jucieli

; Schlemper, Susana Regina de Mello

Ciência Rural

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2021, Volumen 51 Nº 12 elocation e20200855

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: A indústria de alimentos busca a redução de resíduos de antibióticos na criação intensiva de animais de produção devido ao desenvolvimento de bactérias resistentes. Nesse contexto, tem havido um aumento no uso de aditivos fitogênicos alternativos nas rações. Devido às suas propriedades farmacológicas demonstradas anteriormente as plantas Marrubium vulgare e Leonurus sibiricus tem potencial como aditivos em substituição aos antibióticos promotores de crescimento. O objetivo desse estudo foi avaliar o desempenho produtivo e analisar as qualidades sensoriais da carne de frangos que receberam a administração da infusão da M. vulgare (MV) e da L. sibiricus (LS). 320 pintainhas de um criatório industrial foram distribuídas em oito grupos experimentais: Grupo Controle (Salina); Controle Positivo (tilosina 1%, 50 ppm); Grupos tratados com MV: 2% (MV2), 4% (MV4) e 6% (MV6); e grupos tratados com a LS: 2% (LS2), 4% (LS4) e 6% (LS6), e todos eles receberam doses relativas correspondendo à percentagem de peso vivo, em mililitros. Houve maior ganho de peso no 28o dia nos grupos MV6 e LS6 e melhor conversão alimentar em MV4, MV6, LS4 e LS6. Além disso, foi observado aumento no peso e circunferência dos músculos peitorais nesses grupos. A análise sensorial revelou que amostras de carne do grupo MV tiveram sabor mais intenso do que no grupo controle. Na intenção de compra, a carne dos animais que receberam LS teve maior preferência. A melhoria do desempenho produtivo e das características sensoriais da carne de frangos pode estar associada à atividade fitobiótica. Assim, MV e LS podem ser usados como promotores de crescimento naturais para frangos de corte.

ABSTRACT: The food industry is in a continuous search for strategies of reducing of antibiotic residues in livestock production, given the development of antibiotic-resistant bacteria. In that context, there is a consistent increasing in the usage of alternative feed phytogenic additives. Due to the pharmacological, the plants Marrubium vulgare and Leonurus sibiricus, are both potential replacements for growth-promoting antibiotics. This study evaluated the productive performance and analyze the sensory qualities in the meat of broiler that were administered M. vulgare and L. sibiricus infusions. A total of 320 chicks from an poultry farm were distributed in 8 groups groups according treatments by 28 days: Control Group (Saline); Positive control (tylosin 1%, 50 ppm); Groups of M. vulgare (MV) infusion: 2% (MV2), 4% (MV4) and 6% (MV6); and groups treated with L. sibiricus (LS) infusion: 2% (LS2), 4% (LS4) and 6% (LS6), all of them received relative doses corresponding to the live weight percentage in milliliter. There was weght gain in MV6 and LS6 group and a better food conversion in MV4, MV6, LS4, and LS6. In addition, weight gain and enhancement of the pectoral muscles were observed in these groups. The sensory analysis revealed that the broilers’ meat of MV had a more intense flavor. For marketing purposes the meat from birds that received LS had a better demand. Improvement of productive performance and sensory qualities of the broilers meat might be associated with the phytobiotic activity in it. Therefore, MV and LS can be used as natural growth promoter in broilers.

https://doi.org/10.1590/0103-8478cr20200855 157 descargas

Production and composition of milk per Holstein and Jersey cow from two farms in northwest Rio Grande do Sul
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CALGARO, Júlia Laize Bandeira

; FIORESI, Júnior

; VELHO, João Pedro

; STROEHER, Fernanda Hammes

; ALESSIO, Dileta Regina Moro

; PIUCO, Marcos André

; WEBER, Carol Thaís

; HAYGERT-VELHO, Ione Maria Pereira

Revista Brasileira de Saúde e Produção Animal

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2020, Volumen 21 elocation e2121212020

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivou-se realizar o monitoramento por vaca em lactação referente a qualidade e composição do leite de duas propriedades rurais na mesorregião Noroeste Rio-grandense, localizadas nos municípios de Palmeira das Missões e Pinhal - RS. Ambos os rebanhos eram mistos, com animais da raça Holandês (70%) e Jersey (30%). Foram avaliados os parâmetros: escore de condição corporal (ECC), sujidade de úbere, ordem de parto e composição do leite: teores de extrato seco total (EST) e desengordurado (ESD), lactose, gordura, proteína, caseína, nitrogênio ureico do leite (NUL) e contagem de células somáticas (CCS). A análise estatística realizada foi análise fatorial e de agrupamento. O primeiro fator compreende a relação negativa da produção de leite com a raça, teor de gordura e proteína. O segundo fator compreende a relação positiva entre dias em lactação com escore de condição corporal e teor de proteína do leite. O terceiro fator é representado pela relação contrária do teor de lactose com escore de CCS, ordem de parto e ECC. No quarto fator observa-se a relação positiva entre ordem de parto e sujidade do úbere. Na análise de agrupamento foram formados três grupos que refletem as relações encontradas na análise fatorial. O monitoramento por vaca, considerando raça, ordem de parto, escore de condição corporal, dias em lactação, produção de leite, teores de gordura, proteína e lactose, escore de contagem de células somáticas e sujidade do úbere possibilitam maior controle do rebanho, facilitando corrigir possíveis deficiências pontuais de forma rápida e minimizando as perdas produtivas e econômicas.

ABSTRACT The aim of the present study was to monitor cow milk quality and composition in two farms in the Noroeste Rio-grandense mesoregion, located in the municipalities of Palmeira das Missões and Pinhal - RS. Both herds were mixed, with animals of the Holstein (70%) and Jersey (30%) breeds. The following overall parameters were evaluated: body condition score (BCS), udder dirtiness, and calving order, and the following milk composition factors were measured: total dry extract (TDE), defatted dry extract (DDE), milk lactose, fat, and protein contents, casein, milk urea nitrogen (MUN), and somatic cell count (SCC). Multivariate statistical analysis was performed, and four factors were identified representing combinations of the measured variables. The first factor comprised negative relationships between milk production and cow breed, milk fat content, and milk protein content. The second factor comprised the positive relationships between lactation days and body condition score and milk protein content. The third factor represented the negative relationships between milk lactose content and SCC score, calving order, and BCS. The fourth factor was composed of the positive relationship between delivery order and udder dirtiness. Cluster analysis revealed that individual cows could be categorized into three groups. Monitoring the breed, calving order, body condition score, lactation days, milk production, fat, protein, and lactose contents, somatic cell counts, and udder dirtiness in cows allows greater control of the herd, allowing potential shortcomings to be rectified quickly and economic losses to production to be minimized.

https://doi.org/10.1590/s1519-99402121212020 686 descargas

Consensus on the therapeutic management of atopic dermatitis - Brazilian Society of Dermatology
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Aoki, Valeria

; Lorenzini, Daniel

; Orfali, Raquel Leão

; Zaniboni, Mariana Colombini

; Oliveira, Zilda Najjar Prado de

; Rivitti-Machado, Maria Cecília

; Takaoka, Roberto

; Weber, Magda Blessmann

; Cestari, Tania

; Gontijo, Bernardo

; Ramos, Andrea Machado Coelho

; Silva, Claudia Marcia de Resende

; Cestari, Silmara da Costa Pereira

; Souto-Mayor, Silvia

; Carneiro, Francisca Regina

; Cerqueira, Ana Maria Mosca de

; Laczynski, Cristina

; Pires, Mario Cezar

Anais Brasileiros de Dermatologia

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Abr 2019, Volumen 94 Nº 2 Paginas 67 - 75

Resumen: En | Texto: En | PDF: En

Abstract: BACKGROUND: Atopic dermatitis is a highly prevalent inflammatory and pruritic dermatosis with a multifactorial etiology, which includes skin barrier defects, immune dysfunction, and microbiome alterations. Atopic dermatitis is mediated by genetic, environmental, and psychological factors and requires therapeutic management that covers all the aspects of its complex pathogenesis. OBJECTIVES: The aim of this article is to present the experience, opinions, and recommendations of Brazilian dermatology experts regarding the therapeutic management of atopic dermatitis. METHODS: Eighteen experts from 10 university hospitals with experience in atopic dermatitis were appointed by the Brazilian Society of Dermatology to organize a consensus on the therapeutic management of atopic dermatitis. The 18 experts answered an online questionnaire with 14 questions related to the treatment of atopic dermatitis. Afterwards, they analyzed the recent international guidelines on atopic dermatitis of the American Academy of Dermatology, published in 2014, and of the European Academy of Dermatology and Venereology, published in 2018. Consensus was defined as approval by at least 70% of the panel. RESULTS/CONCLUSION: The experts stated that the therapeutic management of atopic dermatitis is based on skin hydration, topical anti-inflammatory agents, avoidance of triggering factors, and educational programs. Systemic therapy, based on immunosuppressive agents, is only indicated for severe refractory disease and after failure of topical therapy. Early detection and treatment of secondary bacterial and viral infections is mandatory, and hospitalization may be needed to control atopic dermatitis flares. Novel target-oriented drugs such as immunobiologicals are invaluable therapeutic agents for atopic dermatitis.

https://doi.org/10.1590/abd1806-4841.2019940210 4086 descargas

10.

Three Main Causes of Homocystinuria: CBS, cblC and MTHFR Deficiency. What do they Have in Common?
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Hoss, Giovana Regina Weber

; Poloni, Soraia

; Blom, Henk J

; Schwartz, Ida Vanessa Doederlein

Journal of Inborn Errors of Metabolism and Screening

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2019, Volumen 7 elocation e20190007

Resumen: En | Texto: En | PDF: En

Abstract Genetic homocystinurias are a group of inborn errors of metabolism that result in the massive excretion of homocysteine (Hcy) in the urine due to Hcy accumulation in the body, usually causing neurological and cardiovascular complications. The three most frequent causes are classical homocystinuria [deficiency of cystathionine beta-synthase (CBS)], methylmalonic aciduria with homocystinuria, cblC type (cblC deficiency) and severe methylenetetrahydrofolate reductase (MTHFR) deficiency. In this review, we highlight the similarities and differences among these disorders. Briefly, their joint manifestation is the accumulation of tHcy, however, the other sulfur amino acids show various and even invers profiles. Vascular disease, developmental delay and seizures are found in all homocystinurias, nevertheless, the complications of CNS differ in a wide variety of presentations and severities and are apparently less pronounced in CBS deficiency. Moreover, patients with remethylation defects typically do not present ectopia lentis and bone disturbances, tall stature and osteoporosis. Whereas hematological alterations, such as megaloblastic anemia, thrombocytopenia neutropenia and life-threatening microangiopathy, are specific findings of cblC deficiency.

https://doi.org/10.1590/2326-4594-jiems-2019-0007 6200 descargas

11.

Pesquisas sobre migrações e etnicidade: conhecimento sobre identidades coletivas
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Weber, Regina

História (São Paulo)

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2018, Volumen 37 elocation e2018006

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo desta análise é mostrar a potencialidade dos processos de migração na geração de identidades coletivas no contexto de chegada. Mais especificamente, buscou-se observar, em termos teóricos, a aplicabilidade das teorias de etnicidade para interpretar as situações manifestadas, tendo por pressuposto que fatores econômicos e sociais influenciam na produção de classificações identitárias. O estudo se amparou em trabalhos de pesquisa sobre migrações internas no país, divulgados em teses, dissertações e artigos acadêmicos, os quais, preferencialmente, utilizaram a metodologia da história oral, pois depoimentos costumam descrever vivamente os momentos e os modos como se exteriorizam as categorias sociais.

ABSTRACT We intend through this analysis to present the potentialities of migration processes in creating collectives identities in the context of peoples’ arrivals. In particular, we tried to observe theoretically the ways ethnicity theories can be applied to interpret some situations under the assumption that economic and social factors influence the creation of identities’ classification. This study was supported by researches on internal migrations in the country, published in theses and dissertations and articles, whose main methodology was oral history, once testimonies are a living source for describing moments and means social categories are exposed.

https://doi.org/10.1590/1980-4369e2018006 1863 descargas

12.

Growth habit effect on development of modern soybean cultivars after beginning of bloom in Rio Grande do Sul
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Zanon, Alencar Junior

; Streck, Nereu Augusto

; Rocha, Thiago Schmitz Marques da

; Alberto, Cleber Maus

; Bartz, Alex Cristiano

; Paula, Gizelli Moiano de

; Tomiozzo, Regina

; Costa, Liege Camargo da

; Fensterseifer, Cesar Augusto

; Tagliapietra, Eduardo Lago

; Cardoso, Ânthony Paz

; Weber, Patric Scolari

; Bexaira, Kelin Pribs

Bragantia

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Dic 2016, Volumen 75 Nº 4 Paginas 445 - 458

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Houve mudança na genética da soja cultivada na região Sul do Brasil a partir dos anos 2000, o que demanda investimento em estudos básicos e detalhados do crescimento e desenvolvimento. O objetivo deste estudo foi caracterizar a duração do período de sobreposição das fases vegetativa e reprodutiva, o crescimento em estatura e a emissão de nós após o início do florescimento em cultivares de tipo de crescimento determinado e indeterminado semeadas em diferentes épocas e regiões produtoras de soja no Rio Grande do Sul. Experimentos de campo foram conduzidos durante os anos agrícolas de 2012/2013 e 2013/2014, em Santa Maria, Itaqui, Frederico Westphalen, Capão do Leão, Júlio de Castilhos e em 3 lavouras comerciais de soja em Restinga Sêca, Tupanciretã e Água Santa. Foram estimadas a sobreposição (em dias) das fases vegetativa e reprodutiva, diferença do número de nós e da estatura em R8 e R1. As cultivares com tipo de crescimento indeterminado apresentaram maior período de sobreposição das fases vegetativa e reprodutiva, crescimento em estatura e emissão de nós após o início do florescimento em comparação com as cultivares determinadas. A magnitude dos valores de sobreposição das fases vegetativa e reprodutiva e do aumento em estatura e número de nós após o R1 variaram com o tipo de crescimento, grupo de maturidade relativa, local e época de semeadura.

ABSTRACT There was a change in the genetics of soybeans grown in southern Brazil from the 2000s, which requires investment in basic and detailed studies about growth and development. The purpose in this paper was to characterize the overlap period of vegetative and reproductive phases, growth in height and the emission of nodes after the beginning of flowering in determinate and indeterminate cultivars in different sowing dates and soybean regions in Rio Grande do Sul. Field experiments were conducted during the growing seasons of 2012/2013 and 2013/2014, in Santa Maria, Itaqui, Frederico Westphalen, Capão do Leão, Júlio de Castilhos and in 3 commercial soybean crops in Restinga Sêca, Tupanciretã and Água Santa. Overlap determination (in days) of vegetative and reproductive phases, difference in the number of nodes and height in R8 and R1 were estimated. The cultivars with indeterminate growth had higher overlap period of vegetative and reproductive phases, height growth and emission of nodes after the beginning of flowering in comparison with the determinate cultivars. The magnitude of the overlap values of vegetative and reproductive phases and of the increase in height and number of nodes after R1 ranged with the type of growth, maturity group, location, and sowing date.

https://doi.org/10.1590/1678-4499.535 2880 descargas

13.

Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats
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Kreuger, Maria Regina Orofino

; Farias, Bruna Gonçalves

; Moreira, Janaína

; Blind, Luise Zozula

; Amoah, Solomon Kweku Sagoe

; Leite, Andreia Siqueira

; Biavatti, Maique Weber

; van Hoof, Tom

; D'Herde, Katharina

; Cruz, Alexandre Bella

Revista Brasileira de Farmacognosia

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Feb 2012, Volumen 22 Nº 1 Paginas 123 - 130

Resumen: En | Texto: En | PDF: En

We investigated the healing process on excisional wounds infected with Staphylococcus aureus in rats, treated with 50 µL of ethyl acetate III from Vernonia scorpioides (Lam.) Pers., Asteraceae, rifamycin diethylamide B 25 mg, or saline. The lesions were measured daily and after seven days were surgically removed and histologically processed. The results indicate a favorable action of the EAIII, demonstrated by the increased wound contraction, smaller area of necrotic tissue, good development of granulation tissue, extensive extracellular matrix deposition and epithelial regeneration. This sub-fraction was phytochemically investigated in parallel studies, revealing the presence of sesquiterpene lactones (glaucolides and hirsutinolides) such as diacethylpiptocarphol and related hirsutinolides, flavonoids and cinnamic acid derivatives and also a new polyacetylene, which have been previously published. Results support the effectiveness of V. scorpioides antimicrobial activity in infected wound healing in rats.

3067 descargas

14.

Discussões preciosas, interlocutores ausentes
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Weber, Regina

Tempo

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2012, Volumen 18 Nº 32 Paginas 255 - 261

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2188 descargas

15.

Zumbido no trabalhador exposto ao ruído
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Weber, Sandra Regina

; Périco, Eduardo

Revista da Sociedade Brasileira de Fonoaudiologia

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Dic 2011, Volumen 16 Nº 4 Paginas 459 - 465

Resumen: Pt En | Texto: Pt En | PDF: Pt | PDF: En

OBJETIVO: Verificar as características, prevalência e repercussão do zumbido em trabalhadores expostos ao ruído. MÉTODOS: Um total de 585 trabalhadores de uma indústria alimentícia foi questionado sobre zumbido. Aqueles que referiram zumbido por mais de cinco minutos e há mais de seis meses responderam à entrevista abordando histórico ocupacional e do zumbido, responderam ao questionário Tinnitus Handicap Inventory, e realizaram audiometria tonal. Foi realizada análise estatística dos dados. RESULTADOS: Foi encontrada prevalência do zumbido de 7,2% (n=42), tempo médio de exposição ao ruído de três anos e oito meses e tempo médio de percepção do zumbido de três anos e sete meses. Verificou-se predomínio da percepção intermitente (88%), bilateral (53,4%), com início progressivo (66,7%). Um total de 50% não apresentou perda auditiva. Os sujeitos referiram que o zumbido interfere principalmente na concentração; estresse, silêncio e barulho foram os fatores de piora mais citados. Houve diferença entre o tempo de exposição ao ruído e o tempo de percepção do zumbido nos indivíduos sem perda auditiva. CONCLUSÃO: A ausência de perda auditiva em metade dos indivíduos e a correlação entre tempo de exposição ao ruído e tempo de percepção do zumbido, nestes indivíduos, apontam para um possível efeito do ruído não limitado ao sistema auditivo periférico e para a necessidade de inclusão do zumbido nos programas de conservação auditiva.

PURPOSE: To verify the characteristics, prevalence, and repercussion of tinnitus in noise-exposed workers. METHODS: A total of 585 workers from a food industry were questioned about tinnitus. Individuals that reported tinnitus with duration of more than five minutes and for more than six months answered an interview regarding occupational and tinnitus histories, answered to the Tinnitus Handicap Inventory questionnaire, and carried out a pure tone audiometry. Data were statistically analyzed. RESULTS: Tinnitus prevalence was 7.2% (n=42), the average noise exposure time was three years and eight months, and the average tinnitus perception time was three years and seven months. There was a predominance of intermittent (88%) and bilateral (53.4%) perception, with progressive onset (66.7%). A total of 50% didn't present hearing loss. The subjects reported that tinnitus interferes mainly in concentration; stress, silence and noise were the worsening factors most frequently mentioned. There was a difference between noise exposure time and tinnitus perception time in individuals without hearing loss. CONCLUSION: The absence of hearing loss in half the individuals and the correlation between noise exposure time and tinnitus perception time, in these subjects, suggest a possible effect of noise not restrained to the peripheral auditory system, and the need to include tinnitus in hearing conservation programs.

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