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ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

https://doi.org/10.1590/s1677-5538.ibju.2023.0065

Nicotinamide and Azospirillum brasilense improves the quality of Coffea arabica seedlings
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Lima, Sebastião F.

; Pinto, Pedro H. G.

; Soares, Manoel P. L.

; Andrade, Maria G. de O.

; Simon, Cátia A.

; Vendruscolo, Eduardo P.

; Contardi, Lucymara M.

; Cordeiro, Meire A. S.

; Abreu, Mariele S.

Revista Brasileira de Engenharia Agrícola e Ambiental

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apr 2023, Volume 27 N. 4 Pages 264 - 271

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O uso de bioestimulantes em mudas de café pode promover ganhos em seu crescimento e na sua qualidade. Assim, o objetivo desse trabalho foi avaliar as características de crescimento e qualidade de mudas de café arábica sob o efeito da aplicação dos bioestimulantes nicotinamida e Azospirillum brasilense. O delineamento experimental utilizado foi o de blocos casualizados, em esquema fatorial 5 × 2, com quatro repetições. Os tratamentos resultaram da utilização de cinco doses de nicotinamida (0, 30, 60, 90 e 120 mg L-1 de água) combinadas com a ausência e presença de Azospirillum brasilense aplicadas em mudas de Coffea arabica da cultivar Catuaí Vermelho 144. Foram avaliadas a altura de planta, diâmetro do caule, número de folhas, área foliar, massa seca da parte aérea, massa seca da raiz, razão entre altura e diâmetro do caule, razão entre massa seca da parte aérea e massa seca da raiz, razão entre altura e massa seca da parte aérea e índice de qualidade Dickson. A utilização conjunta ou isolado do A. brasilense e da nicotinamida, até a dose de 33.5 mg L-1, aumentou características biométricas e acúmulo de massa seca. No entanto, a utilização de doses de nicotinamida entre 30 e 61,8 mg L-1 aumentou da qualidade de mudas de Coffea arabica. Foi verificado efeito sinérgico do uso de A. brasilense e nicotinamida para crescimento e qualidade de mudas.

ABSTRACT The use of biostimulants in coffee seedlings can promote gains in their growth and quality. Thus, this study aimed to evaluate the growth and quality characteristics of Coffea arabica seedlings under the effect of the nicotinamide and Azospirillum brasilense application. The experimental design was randomized blocks with treatments arranged in a 5 × 2 factorial scheme, with four replicates. The treatments resulted from the use of five doses of nicotinamide (0, 30, 60, 90, and 120 mg L-1 of water) combined with the absence and presence of Azospirillum brasilense applied to Coffea arabica seedlings from Catuaí Vermelho 144 cultivar. Plant height, stem diameter, number of leaves, leaf area, shoot dry mass, root dry mass, plant height:stem diameter ratio, shoot:root dry mass ratio, plant height:shoot dry mass ratio, and Dickson quality index were evaluated. The combined or isolated use of A. brasilense and nicotinamide, up to a dose of 33.5 mg L-1, increased the biometric characteristics and dry mass accumulation. However, using nicotinamide doses between 30 and 61.8 g L-1 increased the quality of Coffea arabica seedlings. The synergistic effect of the use of A. brasilense and nicotinamide was verified for the growth and quality of Coffea arabica seedlings.

https://doi.org/10.1590/1807-1929/agriambi.v27n4p264-271

Real-time PCR quantification and histopathological findings of Mycoplasma hyopneumoniae infection in the lungs of pigs slaughtered in São Luís, Maranhão, Brazil
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Rodrigues, Odinéa A.F.

; Dias, Elaine F.

; Freitas, Fernanda M.

; Moreira, Wendel F.F.

; Bezerra, Nancyleni P.C.

; Ribeiro, Diego Luiz S.

; Carvalho Neta, Alcina V.

; Abreu-Silva, Ana Lúcia

; Machado, Rosângela Z.

; Ribeiro, Larissa S.S.

Pesquisa Veterinária Brasileira

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2023, Volume 43 elocation e07233

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT: Porcine enzootic pneumonia (PES), mainly caused by the bacteria Mycoplasma hyopneumoniae, is the main cause of respiratory problems in pigs. Infection by M. hyopneumoniae leads to production losses and the predisposition of affected animals to secondary infections, which may result in the condemnation of carcasses and organs due to lung lesions at the time of slaughter. The objective of the research was to evaluate the infection by M. hyopneumoniae in pigs submitted to slaughter in São Luís Island/MA, using molecular and histopathological diagnostic methods. One hundred fifty lung samples were collected from inspected (n=65) and non-inspected (n=85) slaughter pigs on São Luís Island, Maranhão, from July 2019 to August 2021. Of the 150 DNA samples collected, 121 showed an amplified product for Cyt B in the PCR assay. Thus, 121 samples were submitted to qPCR of M. hyopneumoniae, of which 44 (36.36%) showed positive results. The mean amount of bacterial load ranged from 1.20 × 101 to 7.20 × 104, with a mean of 1.73 × 104 copies. Of the reagent samples, 81.81% (36 samples) were obtained from non-inspected slaughter, while 18.18% (8 samples) were obtained from slaughterhouses. In the histopathological analysis, 44 positive qPCR samples were evaluated, of which 28 (63.63%) presented results compatible with the main inflammatory process associated with the presence of M. hyopneumoniae, that is, bronchial-associated lymphoid tissue hyperplasia (BALT). Three samples that showed the highest bacterial load (qPCR: 5.63 × 10³, 2.19 × 104 and 7.23 × 104) showed more evident lesions in this study. The microscopic findings associated with the quantifications indicated a relationship between the amount of bacterial load and the presence of microscopic lesions; higher bacterial load in lung tissue is associated with increased histopathologic staining for BALT hyperplasia. In conclusion, the results point to the circulation of the etiological agent in the sampled animals and the need for preventive measures on pig farms in Maranhão with the involvement of producers, sanitary defense and inspection agencies.

RESUMO: A pneumonia enzoótica suína (PES), causada principalmente pela bactéria Mycoplasma hyopneumoniae, é a principal causa de problemas respiratórios em suínos. A infecção por M. hyopneumoniae leva a perdas produtivas e a predisposição dos animais acometidos a infecções secundárias, o que pode resultar em condenação de carcaças e órgãos por lesões pulmonares no momento do abate. O objetivo da pesquisa foi avaliar a infecção por M. hyopneumoniae em suínos submetidos ao abate na Ilha de São Luís, por meio de métodos diagnósticos moleculares e histopatológicos. Para isso, foram coletadas 150 amostras de pulmão de suínos de abate inspecionado (n=65) e não inspecionado (n=85) na Ilha de São Luís/Maranhão, no período de julho de 2019 a agosto de 2021. Das 150 amostras de DNA coletadas, 121 apresentaram produto amplificado para Cyt B no ensaio de PCR. Assim, 121 amostras foram submetidas à qPCR de M. hyopneumoniae, das quais 44 (36,36%) apresentaram resultados positivos. A quantidade média de carga bacteriana variou de 1,20 × 101 a 7,20 × 104, com média de 1,73 × 104 cópias. Das amostras reagentes, 81,81% (36 amostras) foram obtidas de abate não inspecionado, enquanto 18,18% (8 amostras) foram obtidas em abatedouro. Na análise histopatológica, foram avaliadas 44 amostras positivas para qPCR, das quais 28 (63,63%) apresentaram resultados compatíveis com o principal processo inflamatório associado à presença de M. hyopneumoniae, ou seja, hiperplasia do tecido linfóide associado ao brônquio (BALT). Três amostras que apresentaram maior carga bacteriana (qPCR: 5,63 × 10³, 2,19 × 104 e 7,23 × 104) foram mais evidentes neste estudo. Os achados microscópicos associados às quantificações indicaram uma relação entre a quantidade de carga bacteriana e a presença de lesão microscópica; a maior carga bacteriana no tecido pulmonar está associada a maior alteração histopatológica para hiperplasia BALT. Em conclusão, os resultados obtidos sinalizam para a circulação do agente etiológico nos animais amostrados e a necessidade de medidas preventivas nas criações de suínos do estado do Maranhão com envolvimento dos produtores, órgãos de defesa sanitária e inspeção.

https://doi.org/10.1590/1678-5150-pvb-7233

Recovery of a degraded area using Platycyamus regnellii (Fabaceae) saplings Fabaceae (Fabaceae
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Bispo, L. F.

; Demolin-Leite, G. L.

; Fagundes, W. M.

; Abreu, A. M. S. A.

; Santos, J. M. M. dos

; Oliveira, F. M. M.

; Silva, V. J.

; Souza, T. O.

; Silva, Y. O. R.

; Amaral, F. L.

Brazilian Journal of Biology

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2023, Volume 83 elocation e278702

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1519-6984.278702

Metabolomic and Histological Response of Passiflora cincinnata Infected with Cowpea aphid-borne mosaic virus (CABMV) Reveals Changes in Asymptomatic and Symptomatic Phases
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Mesquita, Paulo R. R.

; Barbosa, Naira C. S.

; Santos, Fábio N. dos

; Rodrigues, Frederico M.

; Abreu, Emanuel F. M.

; Leite, Kelly R. B.

; Jesus, Onildo N.

; Tumelero, Andréia I.

; Schnadelbach, Alessandra S.

; Barbosa, Cristiane J.

Journal of the Brazilian Chemical Society

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dec 2022, Volume 33 N. 12 Pages 1456 - 1468

Abstract: En | Text: En | PDF: En

Passion fruit woodiness disease, caused by the Cowpea aphid-borne mosaic virus (CABMV), is one of the leading phytosanitary challenges of passion fruit production. Passiflora cincinnata has been recognized for its potential in genetic improvement due to its highest resistance to CABMV and other phytopathogens. Metabolomic and histological alterations of P. cincinnata infected with CABMV were evaluated and searched for differential responses during the asymptomatic or symptomatic infection phases to correlate them with the mechanisms of metabolic defense. The metabolites of infected plants were analyzed by liquid chromatography-mass spectrometry. Based on the metabolomic profile, the times of infection were grouped into early or late infection phases. The metabolites related to CABMV infection were classified as alkaloids, saponins, phospholipids and acids. This study can assist agricultural institutions or farms in the early diagnosis and correct management of CABMV infection and contribute to the genetic improvement of the Passiflora genus against this disease.

https://doi.org/10.21577/0103-5053.20220080

Antibacterial Profile in vitro and in vivo of New 1,4-Naphthoquinones Tethered to 1,2,3-1H-Triazoles Against the Planktonic Growth of Streptococcus mutans
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Gomes, Mônica P.

; Correia, Eduardo M.

; Gomes, Max W. L.

; Santos, Claudio C. C. dos

; Barros, Caroline S.

; Abreu, Fernanda V. de

; Antunes, Leonardo S.

; Ferreira, Vitor F.

; Gonçalves, Mariana C.

; Resende, Gabriel O. de

; Gonzaga, Daniel T. G.

; Pinto, Carla E. C.

; Paixão, Izabel C. N. P.

; Silva, Fernando C. da

Journal of the Brazilian Chemical Society

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sep 2022, Volume 33 N. 9 Pages 1028 - 1040

Abstract: En | Text: En | PDF: En

The cariogenic processes are mainly caused by the bacterium Streptococcus mutans (S. mutans) and consist of the demineralization of the tooth that occurs when the acid production overcomes the natural repair or if a problem occurs in the last one. In this work, we performed the synthesis of twenty-one 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles (8a-8k and 9a-9j), antibacterial evaluation against the S. mutans in vitro and the acute toxicity of the better ones in vivo. We observed strong inhibition results in the disc diffusion test ranging, the halos of inhibitions, from 18.66 (± 0.57) to 29 (± 2.64) mm, and good values in the minimum inhibitory concentration (5 to 50 μg), for the compounds 9e, 9h, 9i and 9j: Furthermore, they do not have a cytotoxic effect at the concentrations tested. Besides that, in the in vivo test, they show some slight alteration in the histopathological analyses and the biochemistry. Thus, we found four potential candidates to become instruments for the treatment of cavities.

https://doi.org/10.21577/0103-5053.20220014

DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE)
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Meireles, Roseana A. R.

; Abreu, Lucas S.

; Silva, Joanda Paolla R. e

; Cavalcanti, Andreza B. S.

; Menezes, Renata Priscila B. de

; Rodrigues, Gabriela Cristina S.

; Rodrigues Junior, Valnês S.

; Melo, José Iranildo M. de

; Kato, Massuo Jorge

; Costa, Vicente Carlos de O.

; Scotti, Marcus Tullius

; Tavares, Josean F.

Química Nova

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sep 2022, Volume 45 N. 9 Pages 1092 - 1097

Abstract: Pt | Text: Pt | PDF: Pt

Phytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-abietane diterpene named 11β,12β-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12α-olide (1), and of nine known ent-abietane diterpenes jolkinolide A (2), jolkinolide E (3), euphorin H (4), euphopilolide (5) jolkinolide F (6), ent-12-hydroxy-12[R]-abieta-8(14),13(15)-dien-16,12-olide (7), ent-11α-hydroxyabieta-8(14),13(15)-dien-16,12α-olide (8), 17-hydroxyjolkinolide B (9) and caudicifolin (10). The structures of all compounds were established using spectroscopic techniques such as 1D and 2D NMR, and the structure of the compound 1 was established also with MS, IR and ECD. All compounds were submitted to an in silico study through of a predictive model and then submitted to in vitro tests against Mycobacterium tuberculosis and M. smegmatis for evaluation of their antimycobacterial activity. Compounds 5 and 9 showed mycobacterial growth inhibition with MIC values of 62.5 μM against M. tuberculosis and M. smegmatis, respectively.

https://doi.org/10.21577/0100-4042.20170932

First list of parasitoids in flies of medical, veterinary, and forensic importance in Rio Grande do Sul – Brazil
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Cárcamo, M. C.

; Guidotti, L.

; Abreu, T. F.

; Egewarth, J.

; Duarte, J. P.

; Costa, V.

Brazilian Journal of Biology

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2022, Volume 82 elocation e238772

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Moscas necrófagas possuem grande importância para a sanidade humana e animal. Onde estas se desenvolvem ocorrem parasitoides que podem ser utilizados como ferramentas para o controle desses dípteros. No Brasil, a fauna desses parasitoides vem sendo investigada em algumas regiões e no Rio Grande do Sul é conhecida a ocorrência de apenas uma espécie. Portanto, o objetivo deste estudo foi criar a primeira lista de espécies de parasitoides de moscas de importância médica e veterinária ocorrentes no extremo sul do Brasil. As coletas foram realizadas no município de Pelotas (31º 42’ S; 52º 18’ O). Foram montadas três réplicas de bandejas contendo, cada uma, 500 g de fígado bovino, expostas ao ar livre durante 20 dias. Na sequência, as pupas foram individualizadas e observadas até a emergência. Foram identificados 4.882 adultos pertencentes às famílias Calliphoridae, Fanniidae, Muscidae e Sarcophagidae. Emergiram 4.040 parasitoides, pertencentes a oito espécies, das quais Nasonia vitripennis, Spalangia cameroni, Spalangia chontalensis e Tachinephagus zealandicus são novas ocorrências para o Rio Grande do Sul. Foram coletadas três espécies ainda não descritas do gênero Aphaereta. Apesar de ainda ser um primeiro esforço de inventariar a fauna de himenópteros parasitoides, este estudo pode auxiliar no desenvolvimento de programas de manejos desses dípteros na região.

Abstract Necrophagous flies are of great importance for human and animal health. In places where their development occurs, parasitoids can be used as a tool to control these dipterans. In Brazil, the fauna of these parasitoids has been investigated in some regions. However, in Rio Grande do Sul, it is known the occurrence of only one species. Thus, this study aimed to create the first list of parasitoids in flies of medical and veterinary importance in Southern Brazil. Collections took place in the municipality of Pelotas (31º 42’ S; 52º 18’ W). Three replicates consisting of a 500 g bovine liver chunk placed in a tray were exposed to open air for 20 days. Then pupae were individualized and observed until their emergence. We identified 4,882 adult flies of Calliphoridae, Fanniidae, Muscidae, and Sarcophagidae. 4,040 parasitoids emerged, belonging to eight species, of which Nasonia vitripennis, Spalangia cameroni, Spalangia chontalensis, and Tachinephagus zealandicus are new records in Rio Grande do Sul state. Also, three undescribed species of the genus Aphaereta were collected. In spite of being the first attempt to inventory the fauna of hymenopteran parasitoids, this study may help in the development of management programs of these dipterans in the region.

https://doi.org/10.1590/1519-6984.238772 208 downloads

Reusable Heterogeneous SnO2/ZnO Catalyst for Biodiesel Production from Acidified/Acid Oils
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Dall’Oglio, Daiane F.

; Garcia, Marco A. S.

; Fiorio, Jhonatan L.

; Abreu, Wiury C. de

; Pereira, Laise N. S.

; Braga, Adriano

; Moura, Edmilson M. de

; Guldhe, Abhishek

; Bux, Faizal

; Moura, Carla V. R. de

Journal of the Brazilian Chemical Society

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jan 2021, Volume 32 N. 1 Pages 182 - 193

Abstract: En | Text: En | PDF: En

A catalyst comprised of SnO2 impregnated on ZnO nanowires, which presented remarkable ability to catalyze fatty acid esterification/transesterification reactions, is reported. For optimization of reaction conditions, artificially acidified soybean oil with 10 wt.% oleic acid was used as a model feed. The optimized conditions were: 150 °C, 6 h, 5 g of oil, catalyst concentration of 5%, and methanol:oil molar ratio of 15:1. The catalyst achieved 92% of total fatty acid methyl esters (FAME) content and was used five times without the necessity of catalyst washing from one reaction to the other. Then, such conditions were applied to produce biodiesel from the oil extracted from Scenedesmus sp. microalgae; the system reached 72% of FAME content, without any previous refining or degumming process of the oil. Rietveld refinement, X-ray diffraction, elemental mapping in scanning transmission electron microscopy, X-ray photoelectron spectroscopy, and pyridine-desorption Fourier-transform infrared spectroscopy were used to characterize the material.

https://doi.org/10.21577/0103-5053.20200167 355 downloads

10.

The effect of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea and uncontrolled hypertension - Study design and challenges during the COVID-19 pandemic
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Cruz, Fernanda C.S.G.

; Drager, Luciano F.

; Queiróz, Daniel B.C.

; Souza, Gabriela A.

; Pedrosa, Rodrigo P.

; Patriota, Tarcya L.G Couto

; Dórea, Egidio L.

; Vieira, Marcelo Luiz C.

; Righi, Camila G.

; Martinez, Denis

; Silva, Geruza A. da

; Silva, Giovanio V.

; Pio-Abreu, Andrea

; Lotufo, Paulo A.

; Benseãor, Isabela M.

; Bortolotto, Luiz A.

; Fuchs, Flávio D.

; Lorenzi-Filho, Geraldo

Clinics

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2021, Volume 76 elocation e2926

Abstract: En | Text: En | PDF: En

OBJECTIVES: To describe the MORPHEOS (Morbidity in patients with uncontrolled HTN and OSA) trial, and describe the challenges imposed by the COVID-19 pandemic. METHODS: MORPHEOS is a multicenter (n=6) randomized controlled trial designed to evaluate the blood pressure (BP) lowering effects of treatment with continuous positive airway pressure (CPAP) or placebo (nasal strips) for 6 months in adult patients with uncontrolled hypertension (HTN) and moderate-to-severe obstructive sleep apnea (OSA). Patients using at least one antihypertensive medication were included. Uncontrolled HTN was confirmed by at least one abnormal parameter in the 24-hour ABPM and ≥80% medication adherence evaluated by pill counting after the run-in period. OSA was defined by an apnea-hypopnea index ≥15 events/hours. The co-primary endpoints are brachial BP (office and ambulatory BP monitoring, ABPM) and central BP. Secondary outcomes include hypertension-mediated organ damage (HMOD) to heart, aorta, eye, and kidney. We pre-specified several sub-studies from this investigation. Visits occur once a week in the first month and once a month thereafter. The programmed sample size was 176 patients but the pandemic prevented this final target. A post-hoc power analysis will be calculated from the final sample. ClinicalTrials.gov: NCT02270658. RESULTS: The first 100 patients are predominantly males (n=69), age: 52±10 years, body mass index: 32.7±3.9 kg/m2 with frequent co-morbidities. CONCLUSIONS: The MORPHEOS trial has a unique study design including a run-in period; pill counting, and detailed analysis of hypertension-mediated organ damage in patients with uncontrolled HTN that will allow clarification of the impact of OSA treatment with CPAP.

https://doi.org/10.6061/clinics/2021/e2926 145 downloads

11.

Selection and use of calling site by Boana leptolineata and Phyllomedusa distincta during the reproductive season
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Farina, Renata K.

; Paraboni, Camila

; Figueiró, Daniela

; Raguse-Quadros, Mateus

; Santos, Charles F. dos

; Ferreira, Pedro M. Abreu

; Tozetti, Alexandro M.

Iheringia. Série Zoologia

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2021, Volume 111 elocation e2021013

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Seleção e uso de sítios de vocalização por Boana leptolineata e Phyllomedusa distincta durante o período reprodutivoAs condições climáticas e as características de micro-habitat, como o substrato e o tipo de vegetação, influenciam a escolha de anuros machos por sítios de vocalização que otimizem seu sucesso reprodutivo. Avaliamos a estrutura e a seleção de micro-habitat de vocalização de 17 indivíduos de Phyllomedusa distincta Lutz, 1950 e 25 de Boana leptolineata (Braun & Braun, 1977), em uma floresta subtropical no sul do Brasil. Medimos a altura do poleiro, a distância do poleiro até a margem do corpo d’água e a estrutura do micro-habitat de quadrantes utilizados pelos indivíduos. Os mesmos atributos foram mensurados nos quadrantes disponíveis (mas não utilizados) pelos indivíduos. Classificamos os micro-habitats por estimativa visual, atribuindo-se porcentagens de cobertura de cada quadrante por vegetação herbácea, arbustiva, arbórea e de área alagada. Observamos que ambas as espécies selecionaram seu micro-habitat, uma vez que as características dos quadrantes ocupados pelos indivíduos foram distintas daquelas disponíveis. Phyllomedusa distincta esteve mais associada a micro-habitats heterogêneos, enquanto B. leptolineata ocorreu em ambientes com maior cobertura de estrato arbóreo. Adicionalmente, observamos que ambas as espécies utilizaram mais frequentemente arbustos como local do poleiro. A seleção destas características de micro-habitat deve estar associada a estratégias para otimização do uso do habitat reprodutivo, baseadas em características morfológicas e comportamentais das espécies. Por fim, é possível inferir que as diferenças observadas na estrutura de micro-habitat selecionadas pelas espécies podem facilitar a coexistência de ambas no contexto da heterogeneidade do ambiente.

ABSTRACT Climatic conditions and microhabitat characteristics, such as the substrate and type of vegetation, influence the choice of male anurans for calling sites that optimize their reproductive success. We evaluated the structure and selection of vocalization microhabitat of 17 individuals of Phyllomedusa distincta Lutz, 1950 and 25 of Boana leptolineata (Braun & Braun, 1977), in a subtropical forest in southern Brazil. We measure the height of the perch, the distance between the perch and the edge of the body of water and the structure of the microhabitat of quadrants used by individuals. The same attributes were measured in the quadrants available (but not used) by the individuals. We classified the microhabitats by visual estimate, assigning percentages of coverage for each quadrant by herbaceous, shrub, tree and wetland vegetation. We observed that both species selected their microhabitat, since the characteristics of the quadrants occupied by the individuals were different from those available. Phyllomedusa distincta was more associated with heterogeneous microhabitats, while B. leptolineata occurred in environments with greater coverage of tree strata. Additionally, we observed that both species used shrubs more frequently as a perch site. The selection of these microhabitat characteristics must be associated with strategies to optimize the use of the reproductive habitat, based on the morphological and behavioral characteristics of the species. Finally, it is possible to infer that the differences observed in the microhabitat structure selected by the species can facilitate the coexistence of both in the context of the heterogeneity of the environment.

https://doi.org/10.1590/1678-4766e2021013 319 downloads

12.

Eosinophilic granuloma: an unusual finding in adults
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Abreu, Bruno F. B. B.

; Duarte, Marcio Luís

; Grande, Murilo G.

; Lima Neto, Newton M.

; Ottoni, Edimeire F.

Jornal Brasileiro de Patologia e Medicina Laboratorial

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2020, Volume 56 elocation e1862020

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Paciente do sexo masculino, 45 anos de idade, apresenta cefaleia occipital há cerca de um mês, resistente ao tratamento com analgesia, e nódulo palpável no local da dor, medindo 1,5 cm de diâmetro, sem aparente alteração da pele. A ultrassonografia revelou uma lesão osteolítica com margens bem definidas e discutível comunicação com a dura-máter. O estudo foi complementado com tomografia computadorizada (TC) e ressonância magnética (RM) com contraste, ambos os exames identificando lesão lítica com componente de partes moles e realce pelo contraste, sem restrição à difusão, orientando a hipótese diagnóstica de granuloma eosinofílico (GE). Instituiu-se então o tratamento cirúrgico com excisão da massa e avaliação anatomopatológica, que confirmou a hipótese diagnóstica radiológica. Com três meses de seguimento, o paciente estava livre de sintomas, e o controle radiográfico não evidenciava sinais de recidiva.

ABSTRACT A 45-year-old man presents with occipital headache for about one month, resistant to analgesic therapy, and palpable nodule at the pain site. At initial evaluation, the nodule was 1.5 cm in diameter without apparent skin alteration. Ultrasonography revealed a well-defined osteolytic lesion and doubtful communication with the dura mater. The study was complemented with computed tomography and contrast-enhanced magnetic resonance, both identifying lytic lesion with soft tissue component and contrast enhancement, without diffusion restriction, guiding the diagnostic hypothesis of eosinophilic granuloma. Surgical treatment with mass excision and anatomopathological evaluation was made, which confirmed the radiological diagnostic hypothesis. After three months of follow-up, the patient remained symptom-free and radiographic control showed no signs of relapse.

RESUMEN Paciente varón de 45 años presenta cefalea occipital desde hace un mes, refractaria a tratamiento analgésico, y nódulo palpable en el lugar del dolor, que mide 1,5 cm de diámetro, sin alteración visible de la piel. La ecografía reveló una lesión osteolítica de bordes bien delimitados y comunicación dudosa con la duramadre. Se complementó el estudio con tomografía computarizada (TC) e imagen por resonancia magnética (IRM) con medio de contraste, ambos exámenes identificando lesión lítica con componente de partes blandas y realce del contraste, sin restricción a la difusión, planteando la hipótesis diagnóstica de granuloma eosinófilo (GE). Se instauró el tratamiento quirúrgico con escisión de la masa y examen anatomopatológico, que confirmó la hipótesis diagnóstica radiológica. A los tres meses de seguimiento, el paciente estaba libre de síntomas, y el control radiográfico no mostró señales de recidiva.

https://doi.org/10.5935/1676-2444.20200025 2196 downloads

13.

Utilization of bedded cattle confinement for organic manure of maize crop
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Mota, Vania C.

; Andrade, Ednilton T.

; Pinto, Sandra M.

; Abreu, Luiz R. de

; Leite, Daniel F.

Revista Brasileira de Engenharia Agrícola e Ambiental

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aug 2019, Volume 23 N. 8 Pages 620 - 624

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O uso de resíduos orgânicos, provenientes de sistema de confinamento no modelo ‘Compost Barn’ poderá suprir grande parte da demanda por adubo na propriedade. Além disso, com o aumento do consumo de alimentos oriundos da pecuária sustentável, a utilização de adubo gerado na própria propriedade se torna economicamente viável. Este trabalho teve como objetivo estudar o efeito da adubação orgânica proveniente da cama de confinamento de bovino aplicada em diferentes momentos no cultivo do milho. O delineamento experimental utilizado foi em blocos casualizados com cinco tratamentos e cinco repetições. Os dados foram submetidos à análise de variância e as médias foram comparadas pelo teste de Scott-Knott a p ≤ 0,05. Os tratamentos com adição de composto fresco e curtido com cobertura nitrogenada apresentaram maior produção de matéria seca da parte aérea do milho quando comparados com os tratamentos sem o uso de composto. Para todas as variáveis analisadas, os tratamentos que utilizaram o composto foram superiores aos demais tratamentos. O solo utilizado no cultivo do milho para silagem melhorou consideravelmente suas características químicas com a aplicação do composto. O aproveitamento do material de cama proveniente de galpões de compostagem, como adubo orgânico, é recomendável como uma alternativa sustentável no reuso e tratamento de dejetos da produção leiteira. Em longo prazo, o material da cama incorpora nutrientes ao solo, aumenta a produção agrícola e agrega valor à propriedade agrícola.

ABSTRACT The use of organic wastes from housing systems in a compost bedded pack barn model could supply much of the fertiliser demand in the farm. Moreover, with the increase in food consumption from sustainable livestock, the use of compost generated in the farm itself becomes economically viable. This study aimed to evaluate the effect of organic manure from bedded cattle confinement applied at different moments on maize crop. The experiment was carried out in a randomized blocks with five treatments and five repetitions. The data were submitted to analysis of variance and the means were compared by Scott-Knott test at p ≤ 0.05. The treatments with addition of fresh compost and mature compost with nitrogen cover had higher production of maize shoot dry matter when compared to treatments without compost. For all variables analysed, the treatments with compost were superior to the other ones. The soil used for growing silage maize has improved considerably its chemical characteristics when the compost was applied. The use of bedding material compost from sheds as organic manure is recommended as a sustainable alternative in the reuse and treatment of waste from cattle confinement farm.

https://doi.org/10.1590/1807-1929/agriambi.v23n8p620-624 1717 downloads

14.

T cell receptor excision circles as a tool for evaluating thymic function in young children
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Levy, A.

; Rangel-Santos, A.

; Torres, L.C.

; Silveira-Abreu, G.

; Agena, F.

; Carneiro-Sampaio, M.

Brazilian Journal of Medical and Biological Research

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2019, Volume 52 N. 7 elocation e8292

Abstract: En | Text: En | PDF: En

The thymus is a primary lymphoid organ responsible for the maturation of T cells as well as the immunological central tolerance. It is in the antenatal period and infancy that it plays its major role. In clinical practice, T cell receptor excision circles (TRECs) are considered a direct and reliable measure of the thymic function. TRECs are a by-product of DNA formation in gene rearrangement of T cell receptors. They are stable and they do not duplicate during mitosis, representing the recent emigrant T cells from the thymus. Despite their importance, TRECs have been neglected by physicians and there is a lack of data regarding thymic function during infancy of healthy children. In order to evaluate thymic function in the first years of life, we propose measuring TRECs as a valuable tool. One hundred and three blood samples from children and adolescents between 3 months and 20 years of age were analyzed. The mean TRECs count was 136.77±96.7 copies of TRECs/μL of DNA. The individuals between 0 and 5 years of age had significantly higher TRECs values than those between 10 and 20 years of age. No significant difference was observed in TRECs values among age groups below 5 years of age. An inverse correlation between TRECs and age was found (r=0.3 P=0.003). These data highlight and validate the evidence of decreased thymus function with age, even during infancy. Awareness should be raised with this important albeit ignored organ.

https://doi.org/10.1590/1414-431x20198292 1094 downloads

15.

Zornioside, a dihydrochalcone C-glycoside, and other compounds from Zornia brasiliensis
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Nascimento, Yuri M.

; Abreu, Lucas S.

; Lima, Ramon L.

; Silva, Anne Dayse S.

; Costa, Vicente Carlos O.

; Melo, José Iranildo M.

; Scotti, Marcus Tulius

; Sobral, Marianna V.

; Araujo, Silvany S.

; G. Filho, Manoel Adrião

; Silva, Marcelo S.

; Tavares, Josean F.

Revista Brasileira de Farmacognosia

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apr 2018, Volume 28 N. 2 Pages 192 - 197

Abstract: En | Text: En | PDF: En

ABSTRACT The secondary metabolites of the aerial parts of Zornia brasiliensis Vogel, Fabaceae, and the biological activity of one of these secondary metabolites were characterized in this study. A phytochemical investigation was performed using chromatographic techniques including analytical and preparative reverse-phase HPLC column sequences, which resulted in the isolation of fourteen compounds: one previously undescribed C-glycosylated dihydrochalcone (zornioside), one cyclitol (D-pinitol), one glycosylated megastigmane (roseoside) and eleven phenolic compounds: 7-methoxyflavanone, 7,4'-dimethoxyisoflavone, medicarpin, 2'-4'-dihydroxychalcone, onionin, isoorientin-3'-O-methyl ether, isovitexin, glycosylated (Z)-O-coumaric acid, glycosylated (E)-O-coumaric acid, dihydromelilotoside, and isoorientin. The structures of the isolated compounds were determined based on 1D and 2D-NMR, HRESIMS, IR and CD spectroscopic analyses. The cytotoxic activity of zornoside was assessed against tumor cell lines (MCF-7, HCC1954, T-47D, 4T1, HL60), and a non-tumor cell line (RAW264.7) using MTT assay. The compound zornioside was selectively cytotoxic for HL60 leukemia cells (IC50: 37.26 µM).

https://doi.org/10.1016/j.bjp.2018.02.003 621 downloads

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