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ABSTRACT Background: Regional information regarding the characteristics of patients with coronavirus disease (COVID)-19 is needed for a better understanding of the pandemic. Objective: The objective of the study to describe the clinical features of COVID-19 patients diagnosed in a tertiary-care center in Mexico City and to assess differences according to the treatment setting (ambulatory vs. hospital) and to the need of intensive care (IC). Methods: We conducted a prospective cohort, including consecutive patients with COVID-19 from February 26, 2020 to April 11, 2020. Results: We identified 309 patients (140 inpatients and 169 outpatients). The median age was 43 years (interquartile range, 33-54), 59.2% men, and 18.6% healthcare workers (12.3% from our center). The median body mass index (BMI) was 29.00 kg/m2 and 39.6% had obesity. Compared to outpatients, inpatients were older, had comorbidities, cough, and dyspnea more frequently. Twenty-nine (20.7%) inpatients required treatment in the IC unit (ICU). History of diabetes (type 1 or 2) and abdominal pain were more common in ICU patients compared to non-ICU patients. ICU patients had higher BMIs, higher respiratory rates, and lower room-air capillary oxygen saturations. ICU patients showed a more severe inflammatory response as assessed by white blood cell count, neutrophil and platelet count, C-reactive protein, ferritin, procalcitonin, and albumin levels. By the end of the study period, 65 inpatients had been discharged because of improvement, 70 continued hospitalized, and five had died. Conclusions: Patients with comorbidities, either middle-age obese or elderly complaining of fever, cough, or dyspnea, were more likely to be admitted. At admission, patients with diabetes, high BMI, and clinical or laboratory findings consistent with a severe inflammatory state were more likely to require IC.

https://doi.org/10.24875/ric.20000211 533 downloads

Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil
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Matos, Diana M.

; Ramalho, Roberto J. R.

; Carvalho, Bruno M.

; Almeida, Maria Augusta C. T.

; Passos, Luciana F. D.

; Vasconcelos, Talmay T. S.

; Melo, Enaldo V.

; Oliveira, Carla R. P.

; Santos, Elenilde G.

; Resende, Karla F.

; Aguiar-Oliveira, Manuel H.

Archives of Endocrinology and Metabolism

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oct 2016, Volume 60 N. 5 Pages 450 - 456

Abstract: En | Text: En | PDF: En

ABSTRACT Objectives To assess the evolution to permanent or transient conditions in children with positive neonatal TSH tests in Sergipe, Brazil, from 2004 to 2010. Subjects and methods Out of 193,794 screened newborns, 713 presented a neonatal TSH level higher than the local cutoff (5.2 µU/mL). From the confirmatory serum TSH values, the children were diagnosed with initial congenital hypothyroidism (CH) or suspect CH. From the evolution, they were classified as permanent CH, hyperthyrotropinemia, or transient TSH elevation. The mean incidence of each final condition was calculated for the total period of time. Results The initial diagnosis included 37 CH (18.1%) and 167 suspect CH (81.9%) cases. The final diagnosis included 46 cases of permanent CH (22.5%), 56 of hyperthyrotropinemia (27.5%), and 102 of transient TSH elevation (50.0%). Out of the 37 cases of initial CH, 23 (62.2%) had permanent CH, nine (24.3%) had hyperthyrotropinemia, and five (13.5%) had transient TSH elevation. Out of the 167 suspect CH cases, 23 (13.8%) had permanent CH, 47 (28.1%) had hyperthyrotropinemia and 97 (58.1%) had transient TSH elevation. The mean incidence after the follow up was 1:4,166 for permanent CH, 1:3,448 for hyperthyrotropinemia, and 1:1,887 for transient TSH elevation. Eighty-six percent of the children with an initial diagnosis of CH and 41.9% with suspect CH had a permanent condition (CH or hyperthyrotropinemia). Conclusions The follow-up of children with an initial diagnosis of CH or suspect CH is necessary to determine whether the disorder is permanent because predicting the evolution of the condition is difficult.

https://doi.org/10.1590/2359-3997000000189 1374 downloads

Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder
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Nery, Fabiano G.

; Gigante, Alexandre D.

; Amaral, Jose A.

; Fernandes, Francy B.

; Berutti, Mariangeles

; Almeida, Karla M.

; Stertz, Laura

; Bristot, Giovana

; Kapczinski, Flavio

; Lafer, Beny

Brazilian Journal of Psychiatry

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sep 2016, Volume 38 N. 3 Pages 197 - 200

Abstract: En | Text: En | PDF: En

Objective: Unaffected relatives of bipolar disorder (BD) patients have been investigated for the identification of endophenotypes in an attempt to further elucidate the pathophysiology of the disease. Brain-derived neurotrophic factor (BDNF) is considered to be implicated in the pathophysiology of BD, but its role as an endophenotype has been poorly studied. We investigated abnormal serum BDNF levels in BD patients, in their unaffected relatives, and in healthy controls. Methods: BDNF levels were obtained from 25 DSM-IV bipolar I disorder patients, 23 unaffected relatives, and 27 healthy controls. All BD patients were in remission. The unaffected subjects were first-degree relatives of the proband who had no lifetime DSM-IV diagnosis of axis I disorder. BDNF serum levels were determined by sandwich ELISA using monoclonal BDNF-specific antibodies. Results: There were no statistical differences in BDNF levels among BD patients, relatives, and healthy controls. Conclusion: Serum BDNF levels may not indicate high genetic risk for BD, possibly acting as state markers rather than trait markers of the disease.

https://doi.org/10.1590/1516-4446-2015-1801 1169 downloads

Association between duration of untreated bipolar disorder and clinical outcome: data from a Brazilian sample
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Medeiros, Gustavo C.

; Senço, Sofia B.

; Lafer, Beny

; Almeida, Karla M.

Brazilian Journal of Psychiatry

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mar 2016, Volume 38 N. 1 Pages 6 - 10

Abstract: En | Text: En | PDF: En

Objective: Bipolar disorder (BD) is often left untreated for long periods, and this delay in treatment correlates with unfavorable prognosis. The present study sought to assess the magnitude of duration of untreated bipolar disorder (DUB) in Brazil. We hypothesized that DUB would be longer in Brazil than in developed countries, and would be associated with poor clinical outcomes. Methods: One hundred and fifty-two psychiatric outpatients were evaluated for BD diagnosis, demographics, DUB, and clinical outcomes. Results: The mean age and mean DUB were, respectively, 38.9±10.8 and 10.4±9.8 years. An extended DUB was associated with early onset of BD (p < 0.001), depression as first mood episode (p = 0.04), and presence of BD in a first-degree relative (p = 0.012). Additionally, a longer DUB was associated with poorer clinical outcomes, such as elevated rates of rapid cycling (p = 0.004) and anxiety disorders (p = 0.016), as well as lower levels of current full remission (p = 0.021). Conclusion: As DUB may be a modifiable variable, better medical education regarding mental health, more structured medical services, and population-wide psychoeducation might reduce the time between onset and proper management of BD, thus improving outcome.

https://doi.org/10.1590/1516-4446-2015-1680 2194 downloads

Cardiovascular risk factors in outpatients with bipolar disorder: a report from the Brazilian Research Network in Bipolar Disorder
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Gomes, Fabiano A.

; Almeida, Karla M.

; Magalhães, Pedro V.

; Caetano, Sheila C.

; Kauer-Sant'Anna, Márcia

; Lafer, Beny

; Kapczinski, Flávio

Brazilian Journal of Psychiatry

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jun 2013, Volume 35 N. 2 Pages 126 - 130

Abstract: En | Text: En | PDF: En

Objective: Bipolar disorder (BD) is associated with significant morbidity and mortality due to comorbid general medical conditions, particularly cardiovascular disease. This study is the first report of the Brazilian Research Network in Bipolar Disorder (BRN-BD) that aims to evaluate the prevalence and clinical correlates of cardiovascular risk factors among Brazilian patients with BD. Methods: A cross-sectional study of 159 patients with DSM-IV BD, 18 years or older, consecutively recruited from the Bipolar Research Program (PROMAN) in São Paulo and the Bipolar Disorder Program (PROTAHBI) in Porto Alegre. Clinical, demographic, anthropometric, and metabolic variables were systematically assessed. Results: High rates of smoking (27%), physical inactivity (64.9%), alcohol use disorders (20.8%), elevated fasting glucose (26.4%), diabetes (13.2%), hypertension (38.4%), hypertriglyceridemia (25.8%), low HDL-cholesterol (27.7%), general (38.4%) and abdominal obesity (59.1%) were found in the sample. Male patients were more likely to have alcohol use disorders, diabetes, and hypertriglyceridemia, whereas female patients showed higher prevalence of abdominal obesity. Variables such as medication use pattern, alcohol use disorder, and physical activity were associated with selected cardiovascular risk factors in the multivariable analysis. Conclusion: This report of the BRN-BD provides new data regarding prevalence rates and associated cardiovascular risk factors in Brazilian outpatients with BD. There is a need for increasing both awareness and recognition about metabolic and cardiovascular diseases in this patient population.

https://doi.org/10.1590/1516-4446-2011-0768 3095 downloads

Variação do diâmetro da artéria braquial em crianças obesas: presente e futuro
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Costa, Karla Cristina M.

; Lima, Jailson Costa

; Almeida, Carlos Alberto N. de

; Ciampo, Luiz Antônio Del

; Souza, Cristiane Simões B. de

Revista Paulista de Pediatria

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sep 2012, Volume 30 N. 3 Pages 431 - 437

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

OBJETIVO: Revisão da literatura acerca do uso da medida da variação do diâmetro da artéria braquial por ultrassonografia de alta resolução (dilatação mediada por fluxo) como preditor de risco para doença cardiovascular em crianças e adolescentes obesos. FONTES DE DADOS: Levantamento de publicações indexadas no Medline/PubMed de trabalhos publicados entre 2002 e 2011, rastreadas com a combinação dos descritores: "endothelium", "child", "ultrasonography" e "obesity", além de estudos e textos clássicos sobre o tema. Foram encontradas 54 publicações e 32 delas foram incluídas na presente revisão do tema. SINTESE DOS DADOS: O estudo da disfunção endotelial tem sido empregado como preditor de risco para doenças cardiovasculares, tais como aterosclerose e doença cardíaca coronariana, visto que a lesão endotelial é um importante evento na fisiopatologia de tais doenças. CONCLUSÕES: A dilatação mediada por fluxo da artéria braquial mostra-se importante como ferramenta diagnóstica e prognóstica na avaliação da função endotelial de crianças e adolescentes com excesso de peso por ser um método não invasivo, com boa aplicabilidade quanto ao custo, à inocuidade e ao benefício.

OBJECTIVE: Literature review on the use of the variation measure of the brachial artery diameter by high-resolution ultrasound (flow-mediated dilation) as a predictor of cardiovascular disease risk in children and adolescents. DATA SOURCE: Survey of studies indexed in Medline/Pubmed, which were published between 2002 and 2011 using the following keywords in various combinations:"endothelium," "child", "ultrasonography" and "obesity", as well as classic texts on the subject. We found 54 publications and 32 were included in this review. SYNTHESIS OF DATA: The study of endothelial dysfunction has been used as a predictor of risk for cardiovascular diseases such as atherosclerosis and coronary heart disease, since endothelial injury is an important event in the physiopathology of these diseases. CONCLUSIONS: The flow-mediated dilation of the brachial artery seems to be important as a diagnostic and prognostic tool to assess endothelial function in children and adolescents who are overweight, because it is a noninvasive method with good profile regarding cost, safety, and benefits.

OBJETIVO: Revisión de la literatura sobre el uso de la medida de la variación del diámetro de la arteria braquial, por ultrasonografía de alta resolución (dilatación mediada por flujo), como predictor de riesgo para enfermedad cardiovascular en niños y adolescentes obesos. FUENTES DE DATOS: Inventario de publicaciones indizadas en Medline/Pubmed de trabajos publicados entre 2002 y 2011, buscadas mediante la combinación de los descriptores: «endothelium», «child», «ultrasonography» y «obesity», además de estudios y textos clásicos sobre el tema. Se encontraron 54 publicaciones y 32 de ésas fueron incluidas en la presente revisión del tema. Síntesis de los datos: El estudio de la disfunción endotelial viene siendo empleado como predictor de riesgo para enfermedades cardiovasculares, tales como aterosclerosis y enfermedad cardíaca coronariana, puesto que la lesión endotelial es un importante evento en la fisiopatología de tales enfermedades. CONCLUSIONES: La dilatación de la arteria braquial mediada por flujo se muestra importante como herramienta diagnóstica y pronóstica en la evaluación de la función endotelial de niños y adolescentes con exceso de peso, por ser un método no invasivo, con buena aplicabilidad respecto al costo, a la inclusión y al beneficio.

3844 downloads

Variabilidade espacial de atributos físicos em solos de vale aluvial no semiárido de Pernambuco
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Santos, Karla S.

; Montenegro, Abelardo A. A.

; Almeida, Brivaldo G. de

; Montenegro, Suzana M. G. L.

; Andrade, Tafnes da S.

; Fontes Júnior, Robertson V. de P.

Revista Brasileira de Engenharia Agrícola e Ambiental

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aug 2012, Volume 16 N. 8 Pages 828 - 835

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

As características físicas e hidráulicas do solo se constituem em condicionantes a planos de manejo agrícola. Objetivou-se avaliar atributos físicos em solos de um vale aluvial e sua variabilidade, no semiárido do Estado de Pernambuco, na bacia hidrográfica do Rio Ipanema. Técnicas estatísticas e geoestatísticas foram utilizadas a fim de se investigar o grau de dependência e a variabilidade espacial dos atributos, em lotes de agricultura familiar. O coeficiente de variação apresentou-se alto para a condutividade hidráulica do solo e médio para a resistência à penetração de raízes e para as frações granulométricas areia, argila e silte. Tal coeficiente foi baixo para a densidade do solo e de partículas e porosidade total. Foram investigadas as estruturas de dependência espacial para as variáveis estudadas, encontrando-se alcances variando de 135 m para a condutividade hidráulica a 465 m para o conteúdo de silte. Mapa de isolinhas foi elaborado por krigagem representando a variabilidade espacial da condutividade hidráulica, com moderado grau de dependência espacial. As frações granulométricas areia total e silte (%) também apresentaram grau de dependência espacial moderado. A resistência à penetração, densidade do solo e de partículas, não apresentaram dependência espacial na escala de investigação adotada. Foi possível identificar regiões de maior aptidão agrícola verificando-se, através do mapeamento, que os solos francos tendem a apresentar elevada resistência à penetração e baixa condutividade hidráulica.

Soil physical and hydraulic characteristics are relevant for agricultural management, particularly at irrigation districts. The objective of this study was to evaluate the spatial variability of physical attributes of soil in an alluvial valley in the semiarid region of Pernambuco State, at the Ipanema River Watershed. Statistical techniques and geostatistics were applied to observe the degree of dependence and the spatial variability of soil physical properties, in plots adopted for communal agriculture. The coefficient of variation for the hydraulic conductivity was high, medium for soil resistance to root penetration and for sand, clay and silt. For bulk density, particle density and porosity, however, such coefficient was low. Spatial dependence structures were investigated, with ranges spanning from 135 m, for soil hydraulic conductivity, to 465 m, for silt content. Contour map was produced by kriging interpolation, representing the spatial variability of hydraulic conductivity, which showed moderate spatial dependence. Resistance to root penetration, soil density and particle distribution presented spatial random behavior, for the adopted spatial scale. It was possible to identify regions with higher agricultural potential. From the produced map, it was highlighted that loam soils usually present higher resistance to root penetration, and low hydraulic conductivity.

3721 downloads

Relationship between botanical origin and antioxidants vitamins of bee-collected pollen
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Oliveira, Karla C. L. S.

; Moriya, Marina

; Azedo, Ricardo A. B.

; Almeida-Muradian, Ligia B. de

; Teixeira, Erica W.

; Alves, Maria L. T. M. F.

; Moreti, Augusta C. de C. C.

Química Nova

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2009, Volume 32 N. 5 Pages 1099 - 1102

Abstract: En | Text: En | PDF: En

This study quantified vitamin C, E and β-carotene in samples of fresh bee-collected pollen and correlating them with the botanical origin. Vitamin content varied between 13.5 and 42.5 µg/g for vitamin E; 56.3 and 198.9 µg/g for β-carotene and 273.9 and 560.3 µg/g for vitamin C. It was concluded that the botanical origin and collecting season influenced the vitamin contents. There is a relationship between the vitamins and its botanical origin: Raphanus sp and Macroptilium sp, Mimosa caesalpineafolia with β-carotene; Raphanus sp, Eucalyptus sp, Macroptilium sp, Mimosa caesalpineafolia with vitamin E and Anadenanthera sp, Arecaceae type and Philodendron sp with vitamin C.

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Oyster spat recruitment in Espírito Santo State, Brazil, using recycled materials
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Nalesso, Rosebel C.

; Paresque, Karla

; Piumbini, Prússia P.

; Tonini, João Filipe R.

; Almeida, Lorena G.

; Níckel, Vanessa M.

Brazilian Journal of Oceanography

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dec 2008, Volume 56 N. 4 Pages 281 - 288

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este trabalho avaliou a eficiência de quatro tipos de coletores de sementes no recrutamento de ostras Crassostrea sp., em cinco pontos do estuário do Rio Benevente, município de Anchieta, e em duas ilhas no município de Piúma, estado do Espírito Santo. Foram utilizados quatro tipos de coletores: 1-conchas de ostras, 2- garrafas PET, 3-tiras de pneu e 4- telhas, todos suspensos por cordas e amarrados em rizóforos de Rhizophora mangle ou em "long-lines" de mexilhões. Bimensalmente, as sementes recrutadas foram contadas e medidas quanto à altura, determinando-se os parâmetros físico-químicos-tróficos da água: salinidade, temperatura, oxigênio dissolvido, matéria orgânica particulada e clorofila-a, que foram correlacionados com o número de sementes nos coletores (através de correlações de Spearman). O recrutamento de sementes foi significativamente maior nos coletores de conchas de ostras, telhas e pneus, principalmente nos pontos de salinidade mais alta (Praia do Coqueiro em Anchieta e Ilhas do Meio e do Cabrito em Piúma) (Kruskal-Wallis: H= 10,01; 3 g.l.; P < 0,05). A fixação de sementes ocorreu durante todo o ano, sendo mais alta de novembro a fevereiro; porém, devido ao alto número de coletores perdidos por roubo ou tempestades, esta diferença não foi significativa (Kruskal-Wallis: H=1,42; 7 g.l.; P >0,05). O número de sementes de ostras foi positivamente correlacionado com a salinidade (ρs= 0,331; P < 0,05) e temperatura da água (ρs= 0,48; P < 0,05), indicando que os locais de salinidades mais altas e os meses de verão são os melhores para se coletar sementes de ostras.

This paper evaluated the effectiveness of four types of oyster spat collectors, made with recycled materials, in the recruitment of the mangrove oyster Crassostrea spp. at five sites in the Benevente river estuary, Anchieta District and on two islands in Piúma District, both in Espírito Santo State. The collectors were made of: 1- oyster shells, 2- PET bottles, 3- car tires and 4- tiles, all of them suspended by ropes and tied to roots of Rhizophora mangle or mussel long-lines. The number of spat recruited on each collector and their shell lengths were registered bimonthly, as well as the physico-chemical-trophic parameters of the water: salinity, temperature, dissolved oxygen, particulate organic matter and chlorophyll a, which were correlated (by Spearman's correlation) with the number of spat recruited. Spat settlement was significantly higher on oyster shell, tile and tire collectors, mainly at points with higher salinities, such as Praia do Coqueiro in Anchieta and on Meio and Cabrito Islands in Piúma (Kruskal-Wallis: H= 10.01; 3 d.f.; p < 0.05). Oyster spat recruitment occurred throughout the year, being higher from November to February, but because of losses due to storms or theft, the difference was not statistically significant (Kruskal-Wallis: H=1.42; 7 d.f.; p > 0.05). The number of oyster spat was positively correlated with the salinity (ρs= 0.331; p < 0.05) and water temperature (ρs= 0.48; p < 0.05), revealing that areas with higher salinities and summer months were better for spat collection.

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10.

Fitossociologia do componente lenhoso de um refúgio vegetacional no município de Buíque, Pernambuco
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RODAL, MARIA JESUS NOGUEIRA

; ANDRADE, KARLA VITÓRIA DE ALMEIDA

; SALES, MARGARETH FERREIRA

; GOMES, ANA PAULA SOUSA

Revista Brasileira de Biologia

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aug 1998, Volume 58 N. 3 Pages 517 - 526

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Com o objetivo de contribuir para o conhecimento da vegetação lenhosa das chapadas sedimentares do sertão de Pernambuco, foi realizada a caracterização fisionômica e a análise da estrutura da vegetação arbustiva perenifólia localizada em uma vertente a barlavento da serra do Catimbau, na propriedade sítio Cigano, Buíque (8°67'LS e 37°1' LW) a 800 m de altitude. Em cem pontos quadrantes, distribuídos em 10 linhas paralelas, interdistantes 30 m, cada uma com 10 pontos quadrantes distanciados 10 m, foram amostrados todos os indivíduos com diâmetro do caule > ou = 3 cm no nível do solo e altura total > ou = 1 m. Densidade total, área basal total, alturas e diâmetros médios e máximos foram de 2.207,7 ind./ha, 6,07 m²/ha, 2,3 m e 7,0 m, 5,1 cm e 21,96 cm, respectivamente, revelando um padrão fisionômico distinto das vegetações de caatinga e carrasco estudadas no nordeste do Brasil. Das 35 espécies amostradas, Eremanthus capitatus, Piptadenia obliqua, Gochnatia oligocephala, Senna cana var. cana e Eugenia punicifolia foram responsáveis por 63,3% do índice do valor de importância total. O índice de diversidade de Shannon para espécies foi de 2,73 nats/ind.

Phytosociology of the woody component of a vegetacion refuge in the municipality of Buíque, Pernambuco. Physiognomy and structure of a evergreen shrub vegetation found on the windward slope of the Catimbau range, at the Cigano property, Buíque (8°67'LS and 37°1' LW, altitude 800 m) were determined, as a contribution to the knowledge of the vegetation on sedimentary plateaus of Pernambuco. The point centered quarter method was used with 100 points distributed in 10 parallel lines, each point 10 m and each line 30 m apart. All living and standing dead individuals with stem diameter > or = 3 cm at soil level and plant height > or = 1 m were sampled. Total density, total basal area, average and largest diameter and height were 2.208 ind./ha, 6.07 m²/ha, 5.1 cm and 22.0 cm and 2.3 m and 7 m, respectively, revealing a shrub pattern different from those of the caatinga and carrasco studied in Northeastern Brasil. Of the 35 sampled species, Eremanthus capitatus, Piptadenia obliqua, Gochnatia oligocephala, Senna cana var. cana and Eugenia punicifolia were reponsible for 63.3% of the importance value index total. Shannon diversity index for species was 2.73 nats/ind.

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