Resumo Objetivo Analisar a experiência do estigma em narrativas sobre o adoecimento crônico de homens em tratamento hemodialítico. Métodos Estudo qualitativo desenvolvido com 24 homens em Unidade de Hemodiálise em cidade localizada na região nordeste do Brasil. Os dados foram extraídos de entrevistas individuais em profundidade, submetidas à análise metodológica do Discurso do Sujeito Coletivo e interpretados à luz da teoria do estigma. Resultados As narrativas indicam as marcas da doença, quando estranham o próprio corpo e se percebem diferentes. Evidencia componentes do estigma a exemplo do descrédito, perda do status, afastamento e aplicação de rótulos. Também percebem as consequências da estigmatização, adotam medidas de autopreservação e ressaltam a importância do cuidado recebido de enfermeiras para seu enfrentamento. Conclusão A estigmatização cria barreiras para a sociabilidade, acesso a bens e serviços de saúde e seguridade social, e repercute sobre a imagem corporal, adaptação e enfrentamento do adoecimento crônico.

Abstract Objective To analyze the experience of stigma in narratives about the chronic illness of men on hemodialysis. Method Qualitative study conducted with 24 men in a Hemodialysis Unit in a city located in the Northeast region of Brazil. Data were extracted with in-depth individual interviews, which were analyzed according to the Discourse of the Collective Subject and interpreted under the light of stigma theory. Results The narratives indicate the marks of the disease, when men are placed at odds with their own bodies and perceive themselves as different. The results show components of stigma such as discredit, loss of status, estrangement and labeling. The men also perceive the consequences of stigmatization, adopt self-preservation measures and emphasize the importance of the care received from nurses to face this reality. Conclusion Stigma creates barriers to socialization, access to health and social security and affects body image, adaptation and coping with chronic illness.

Resumen Objetivo Analizar la experiencia del estigma en narrativas sobre la dolencia crónica de hombres en tratamiento hemodialítico. Métodos Estudio cualitativo desarrollado con 24 hombres en Unidad de Hemodiálisis en una ciudad ubicada en la región nordeste de Brasil. Los datos se obtuvieron mediante entrevistas individuales en profundidad, sometidas al análisis metodológico del Discurso del Sujeto Colectivo e interpretados a la luz de la teoría del estigma. Resultados Las narrativas indican las marcas de la enfermedad, al extrañar el propio cuerpo y se perciben distintos. Evidencia componentes del estigma como ejemplo del descrédito, pérdida del estatus, alejamiento y atribución de clasificaciones. De la misma forma perciben las consecuencias de la estigmatización, adoptan medidas de autopreservación y destacan la importancia del cuidado recibido de las enfermeras para el enfrentamiento. Conclusión La estigmatización crea barreras para la sociabilidad, acceso a bienes y servicios de salud y seguridad social y tiene y repercute sobre la imagen corporal, adaptación y enfrentamiento de la enfermedad crónica.

Background: Xylitol is a five carbons polyol with promising medical applications. It can be obtained from chemical D-xylose reduction or by microbial fermentation of Sugarcane Bagasse Hemicellulosic Hydrolysate. For this last process, some microbial inhibitors, as furfural, constitute severe bottleneck. In this case, the use of strains able to produce xylitol simultaneously to furfural neutralization is an interesting alternative. A wild-type strain of Geotrichum sp. was detected with this ability, and its performance in xylitol production and furfural consumption was evaluated. Furthermore, were analyzed its degradation products. Results: Geotrichum sp. produced xylitol from D-xylose fermentation with a yield of 0.44 g-g-1. Furfural was fully consumed in fermentation assay and when provided in the medium until concentration of 6 g-L-1. The furfural degradation product is not an identified molecule, presenting a molecular weight of 161 g-mol-1, an uncommon feature for the microbial metabolism of this product. Conclusion: This strain presents most remarkable potential in performing furfural consumption simultaneous to xylitol production. Subsequent efforts must be employed to establish bioprocess to simultaneous detoxification and xylitol production by Geotrichum sp.

The dereplication of aporphine and oxoaporphine alkaloids by direct infusion in ESI-IT-MSn system was applied for alkaloidal fractions of the Unonopsis guatterioides (Annonaceae). Its main advantage over other dereplication methods is the ability to quickly identify substances in complex mixtures without the use of coupled techniques and expensive databases. By only the fragmentation keys and comparison with literature data the aporphine alkaloids anonaine, asimilobine and nornuciferine were identified. The nornuciferine is being reported for the first time in Unonopsis. The oxoaporphine alkaloids liriodenine and lisycamine were identified in the alkaloidal fractions by comparison with the fragmentations of authentic samples.

Protium é um gênero que se destaca na família Burceraceae, compreende cerca de 146 espécies, das quais um pequeno número tem sido estudada do ponto de vista fitoquímico. Neste trabalho, foram isolados os terpenoides α- e β-amirina, os esteroides campesterol, estigmasterol e sitosterol e a cumarina escopoletina, a partir do tronco de Protium hebetatuml. As estruturas destas substâncias foram identificadas por RMN, MS, IV e por comparação com dados espectrais obtidos naa literatura e com amostras autênticas.

Protium is the largest genus in the Burceraceae family, which comprises about 146 species, of which a small number has been studied from the phytochemical point of view. In this work the terpenoids α- and β-amyrin, the steroids campesterol, stigmasterol and sitosterol and the coumarin scopoletin were isolated from the stem of Protium hebetatuml. The structures of these substances were identified by NMR, MS, IV and comparison with spectral data from the literature and with authentic samples.

The alkaloid glandicoline B (1) and six other compounds: ergosterol (2), brassicasterol (3), ergosterol peroxide (4), cerevisterol (5), mannitol (6) and 1-O-α-D-glucopyranoside (7) were isolated from Penicillium sp. strain PBR.2.2.2, a fungus from Mauritia flexuosa roots. The structures of the isolated metabolites were established by spectral analysis. MeOH extract of the fungal mycelium at 500 µg mL-1 exhibited antimicrobial activity against Staphylococcus aureus and the compound 1 at 100 µg mL-1 was active against S. aureus, Micrococcus luteus and Escherichia coli. The relationship between the bioactive properties of the fungus PBR.2.2.2 and those achieved for glandicoline B, as well the potential of this substance as bactericide is discussed.