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Primary hypothyroidism with exuberant dermatological manifestations,
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Silva, Thadeu Santos

; Faro, Gustavo Baptista de Almeida

; Cortes, Márcia Gabrielle Bonfim

; Rego, Vitória Regina Pedreira de Almeida

Anais Brasileiros de Dermatologia

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dec 2020, Volume 95 N. 6 Pages 721 - 723

Abstract: En | Text: En | PDF: En

Abstract Thyroid hormone has effects on the skin. Patients with hypothyroidism have changes such as dry, scaly and rough skin. Increase carotene in the dermis becomes a yellowish tone to the skin of the patient with hypothyroidism. There is an increase in capillary cycle (anagen phase) and nail growth and a reduction in eccrine gland secretion. It is a case of primary hypothyroidism with nail manifestations associated with dermatologic disorders and successful treatment with levothyroxine. Receptors for thyroid hormone have already been found in keratinocytes, fibroblasts, hair follicles and sebaceous glands. Genes responsive to thyroid hormones and elements of the hypothalamic–pituitary–thyroid axis were identified on the skin. This report highlights the importance of cutaneous manifestations as markers of thyroid disease.

https://doi.org/10.1016/j.abd.2019.07.010 389 downloads

Purpura annularis telangiectodes of Majocchi,
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Garcez, Aline Soares

; Rego, Vitória Regina Pedreira de Almeida

; Silva, Thadeu Santos

Anais Brasileiros de Dermatologia

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oct 2020, Volume 95 N. 5 Pages 664 - 666

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2020.02.007 447 downloads

Lobular capillary hemangioma in a patient with ankylosing spondylitis using adalimumab: an exuberant presentation,
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Silva, Thadeu Santos

; Guimarães, Carlos Leonardo Martins

; Xavier, Isabela Pimenta

; Rego, Vitória Regina Pedreira de Almeida

Anais Brasileiros de Dermatologia

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nov 2019, Volume 94 N. 6 Pages 751 - 753

Abstract: En | Text: En | PDF: En

Abstract Lobular capillary hemangioma or pyogenic granuloma is a benign vascular tumor of the skin or mucous membranes. Most patients present a single lesion. It manifests clinically as an erythematous, friable, and fast-growing tumor. This report details a case with exuberant presentation in a patient with ankylosing spondylitis, using adalimumab. Factors triggering pyogenic granuloma are not well known. They may spontaneously regress, but most require treatment.

https://doi.org/10.1016/j.abd.2019.02.004 225 downloads

Papillon-Lefèvre syndrome
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Silva, Thadeu Santos

; Lacerda, Priscila Neri

; Rêgo, Fernanda Pedreira de Almeida

; Rêgo, Vitória Regina Pedreira de Almeida

Anais Brasileiros de Dermatologia

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oct 2018, Volume 93 N. 5 Pages 771 - 772

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/abd1806-4841.20187896 1033 downloads

Brazilian Consensus on Photoprotection
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Schalka, Sérgio

; Steiner, Denise

; Ravelli, Flávia Naranjo

; Steiner, Tatiana

; Terena, Aripuanã Cobério

; Marçon, Carolina Reato

; Ayres, Eloisa Leis

; Addor, Flávia Alvim Sant'anna

; Miot, Helio Amante

; Ponzio, Humberto

; Duarte, Ida

; Neffá, Jane

; Cunha, José Antônio Jabur da

; Boza, Juliana Catucci

; Samorano, Luciana de Paula

; Corrêa, Marcelo de Paula

; Maia, Marcus

; Nasser, Nilton

; Leite, Olga Maria Rodrigues Ribeiro

; Lopes, Otávio Sergio

; Oliveira, Pedro Dantas

; Meyer, Renata Leal Bregunci

; Cestari, Tânia

; Reis, Vitor Manoel Silva dos

; Rego, Vitória Regina Pedreira de Almeida

Anais Brasileiros de Dermatologia

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dec 2014, Volume 89 N. 6 Pages 1 - 74

Abstract: En | Text: En | PDF: En

Brazil is a country of continental dimensions with a large heterogeneity of climates and massive mixing of the population. Almost the entire national territory is located between the Equator and the Tropic of Capricorn, and the Earth axial tilt to the south certainly makes Brazil one of the countries of the world with greater extent of land in proximity to the sun. The Brazilian coastline, where most of its population lives, is more than 8,500 km long. Due to geographic characteristics and cultural trends, Brazilians are among the peoples with the highest annual exposure to the sun. Epidemiological data show a continuing increase in the incidence of non-melanoma and melanoma skin cancers. Photoprotection can be understood as a set of measures aimed at reducing sun exposure and at preventing the development of acute and chronic actinic damage. Due to the peculiarities of Brazilian territory and culture, it would not be advisable to replicate the concepts of photoprotection from other developed countries, places with completely different climates and populations. Thus the Brazilian Society of Dermatology has developed the Brazilian Consensus on Photoprotection, the first official document on photoprotection developed in Brazil for Brazilians, with recommendations on matters involving photoprotection.

https://doi.org/10.1590/abd1806-4841.20143971 14207 downloads

Anti-TNFα therapy in the management of psoriasis: experience of a state referral center
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Silva, Laura Maria Andrade

; Rocha, Bruno de Oliveira

; Nobre, Ana Cláudia Pinto

; Rêgo, Vitória Regina Pedreira de Almeida

; Follador, Ivonise

; Oliveira, Maria de Fátima Santos Paim de

Anais Brasileiros de Dermatologia

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jun 2014, Volume 89 N. 3 Pages 436 - 440

Abstract: En | Text: En | PDF: En

BACKGROUND:Psoriasis is a chronic immune-mediated disease, characterized by increased levels of TNFα. Anti-TNFα agents have revolutionized the treatment of severe psoriasis by targeting an important molecule involved in its pathogenesis.OBJECTIVES:We report the experience of a state referral center that uses anti-TNFα agents for psoriasis.METHODS:We conducted a retrospective case series. Seventy-four out of 120 patients met the inclusion criteria. Clinical and laboratory data was analyzed using the chi-squared, Wicoxon and McNemar's tests. Associations were considered statistically significant when p-value<0.05.RESULTS:Forty-one subjects (55.40%) were male, with a mean age of 47.69±14.99 years. Median disease duration and pre-treatment PASI were 14.0 months (IQR 9.0-20.0), and 13.55 points (IQR 8.5-20.32). Sixty patients (81.10%) had arthropathic psoriasis. Forty-six subjects (62.20%) had comorbidities; the most frequent was dyslipidemia (25.70%). In 55.40% of patients, insufficient response to conventional therapies was the principal indication for using anti-TNFα drugs. Clinical improvement occurred in 93.20% of cases, and the post-treatment PASI median was 0.0 points (IQR 0.0-0.0). Adverse effects occurred in 6.80% of patients. Infections and elevation of transaminases occurred in 28.40% and 8.10% of cases, respectively.CONCLUSION:Post-treatment reduction in PASI was satisfactory and the occurrence of adverse effects was minor, mostly mild infusion effects and local reactions at drug administration sites.

https://doi.org/10.1590/abd1806-4841.20142613 1858 downloads

Do you know this syndrome?
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Silveira, Laura Maria Andrade

; Ramos, Andreia Nogueira

; Amaral, Isadora Rosado do

; Rego, Vitoria Regina Pedreira de Almeida

Anais Brasileiros de Dermatologia

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jun 2013, Volume 88 N. 3 Pages 473 - 475

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A hipertricose Lanugionsa Congênita é uma desordem genética rara, autossômica dominante, com menos de 50 casos descritos na literatura. É caracterizada por pêlo lanugo excessivo, poupando apenas membranas mucosas, palmas e plantas. Pode estar associada a outras anormalidades orgânicas, devendo ser de conhecimento do dermatologista. Discutiremos aspectos da síndrome em questão a partir do relato de caso de uma paciente do sexo feminino, negra, 02 anos, com apresentação clínica clássica, sem outras anormalidades congênitas associadas.

Congenital Hypertrichosis Lanugionsa is a rare autosomal dominant genetic disorder, with fewer than 50 cases reported in the literature. It is characterized by excessive lanugo hair, sparing only the mucous membranes, palms and soles. It may be associated with other organic abnormalities and should form part of the dermatologist's current knowledge. We discuss some aspects of the syndrome in question arising from the case report of a 2-year-old female patient, black, with classic clinical presentation, with no other associated congenital abnormalities.

https://doi.org/10.1590/abd1806-4841.20131965 5666 downloads

Inherited epidermolysis bullosa: clinical and therapeutic aspects
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Boeira, Vanessa Lys Simas Yamakawa

; Souza, Erica Sales

; Rocha, Bruno de Oliveira

; Oliveira, Pedro Dantas

; Oliveira, Maria de Fátima Santos Paim de

; Rêgo, Vitória Regina Pedreira de Almeida

; Follador, Ivonise

Anais Brasileiros de Dermatologia

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apr 2013, Volume 88 N. 2 Pages 185 - 198

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A epidermólise bolhosa hereditária (EBH) compreende um grupo heterogêneo de desordens genéticas que têm em comum a fragilidade cutânea e, em alguns casos mucosa, predispondo ao desenvolvimento de bolhas e/ou erosões após fricção ou trauma mínimo. Crianças com história recorrente deste tipo de lesão ou neonatos que as apresentem na ausência de outra explicação plausível devem ser investigados. O diagnóstico deve se basear em achados clínicos e histopatológicos. Até o presente momento, o manejo da EBH consiste basicamente em evitar os traumas desencadeadores das lesões, bem como evitar a infecção e facilitar a cicatrização das feridas com o uso sistemático de curativos.

Inherited epidermolysis bullosa (EB) is a heterogeneous group of genetic disorders that present with skin and, in some cases, mucosal fragility, predisposing patients to the development of blisters and/or erosions after minimal trauma or friction. Children with a recurrent history of these kinds of lesions or neonates that present them in the absence of another reasonable explanation should be investigated. Diagnosis must be based on clinical and histopathological findings. To date, management of inherited EB basically consists in avoiding traumas that trigger lesions, as well as preventing infection and facilitating healing of the wounds with the systematic use of bandages.

https://doi.org/10.1590/S0365-05962013000200001 12153 downloads

Queratose liquenoide crônica: relato de caso
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Martins, Livia Cibele Gomes

; Horne, Marina

; Moreira Júnior, Dário Nunes

; Follador, Ivonise

; Almeida, Vitória Regina Pedreira de

Anais Brasileiros de Dermatologia

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aug 2011, Volume 86 N. 4 Pages 148 - 151

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A queratose liquenoide crônica ou doença de Nekam é uma dermatose mucocutânea rara da queratinização, com curso crônico e progressivo, que acomete geralmente indivíduos entre 20 e 40 anos. Existem, aproximadamente, 70 casos descritos na literatura. Devido à raridade desta dermatose e à ausência de tratamento efetivo, é uma doença de difícil manejo. No caso em questão, apresentamos um paciente de 42 anos com pápulas violáceas, hiperqueratósicas, algumas confluentes, com aspecto linear, rendilhado e em placas, localizadas no tronco e membros há cinco anos. Lesões aftoides na cavidade oral e úlceras rasas na genitália também faziam parte do quadro. O anatomopatológico foi bastante sugestivo de queratose liquenoide crônica. Introduziu-se tratamento com acitretina e dapsona, havendo melhora parcial do quadro

Keratosis lichenoides chronica or Nekam's disease is a rare mucocutaneous dermatosis characterized by keratinization. It is chronic and progressive usually affecting individuals aged 20-40 years. Around 70 cases have been reported in the literature. Due to the rarity of this condition and the lack of effective treatment, it is a difficult disease to manage. In the case described below we present a 42-yearold patient with violaceous and hyperkeratotic papules in linear, reticular or plaque form, located on the trunk and limbs for five years. Aphthous lesions in the oral cavity and shallow ulcers on the genitalia also formed part of the clinical manifestation. Pathologic examination was suggestive of keratosis lichenoides chronica. Acitretin and dapsone was introduced and the lesions partially improved

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Psoríase eritrodérmica refratária em criança com excelente resposta ao etanercepte
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Fraga, Naiara Abreu de Azevedo

; Paim, Maria de Fátima

; Follador, Ivonise

; Ramos, Andréia Nogueira

; Rêgo, Vitória Regina Pedreira de Almeida

Anais Brasileiros de Dermatologia

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aug 2011, Volume 86 N. 4 Pages 144 - 147

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A psoríase acomete 0,12% a 0,71% da população infantil, sendo que a forma eritrodérmica, grave e rara, ocorre em menos de 1,5% dos casos. Os antagonistas do Fator de Necrose Tumoral-α (TNFα) constituem nova classe de drogas, utilizada para tratamento da psoríase grave a moderada, refratária às terapias convencionais. O Etanercepte é uma proteína de fusão do receptor do TNF-α, aprovada pelo Food and Drug Administration para tratamento da artrite reumatoide juvenil no grupo infantil. Apresentamos um caso de criança com 7 anos de idade, com psoríase em placa desde 8 meses de vida, que evoluiu para eritrodermia refratária a ciclosporina e metotrexato, com excelente resposta ao etanercepte, sem feitos adversos

Psoriasis affects 0.12% to 0.71% of all children. Erythrodermic psoriasis is an uncommon but serious disorder, occurring in less than 1.5% of cases. Tumor necrosis factor-alpha blockers (TNF-α) are a new class of drugs used to treat moderate to severe psoriasis refractory to conventional therapies. Etanercept is a TNFα receptor fusion protein, approved by the FDA for treating juvenile rheumatoid arthritis. We present the case of a 7-year-old suffering from plaque psoriasis since 8 months old which evolved into erythroderma refractory to cyclosporine and methotrexate. Patient responded excellently to etanercept, with no adverse side effects

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