ABSTRACT Purpose: To evaluate the potential oncologic benefit of a visibly complete transurethral resection of a bladder tumor (TURBT) prior to neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). Materials and Methods: We identified patients who received NAC and RC between 2011-2021. Records were reviewed to assess TURBT completeness. The primary outcome was pathologic downstaging (<ypT2N0), with complete pathologic response (ypT0N0) and survival as secondary endpoints. Logistic regression and Cox proportional hazards models were utilized. Results: We identified 153 patients, including 116 (76%) with a complete TURBT. Sixty-four (42%) achieved <ypT2N0 and 43 (28%) achieved ypT0N0. When comparing those with and without a complete TURBT, there was no significant difference in the proportion with <ypT2N0 (43% vs 38%, P=0.57) or ypT0N0 (28% vs 27%, P=0.87). After median follow-up of 3.6 years (IQR 1.5-5.1), 86 patients died, 37 died from bladder cancer, and 61 had recurrence. We did not observe a statistically significant association of complete TURBT with cancer-specific or recurrence-free survival (p≥0.20), although the hazard of death from any cause was significantly higher among those with incomplete TURBT even after adjusting for ECOG and pathologic T stage, HR 1.77 (95% CI 1.04-3.00, P=.034). Conclusions: A visibly complete TURBT was not associated with pathologic downstaging, cancer-specific or recurrence-free survival following NAC and RC. These data do not support the need for repeat TURBT to achieve a visibly complete resection if NAC and RC are planned.

ABSTRACT To study the antimicrobial and uric acid-preserving activity of pine bark tannin on poultry litter composting, antibiotic-free wood chip-based poultry litter was distributed (11 g) to 50-mL conical centrifuge tubes and immediately amended with 1.3 mL0.4 M sodium phosphate buffer (control) or with 1.3 mL condensed tannins from pine bark (Pinus palustris; 9 % tannin wt/vol in water). All tubes (n = 3 tubes/treatment) were inoculated with a novobiocin and naladixic acid-resistant Salmo-nella typhimurium (STNN) to achieve 3.0 log10 CFU/g and incubated at 37oC for 3 days to simulate an initial compost period. Wildtype E. coli and the challenge STNN strain as well as concentrations of ammonia, uric acid and urea were measured on days 0 and 3. Pine bark tannin treatment decreased (p<0.01) STNN populations in the litter by 0.6 log units compared to the controls. Wildtype E. coli populations were unaffected by tannin treatment (p>0.05). Ammonia accumulation decreased (p<0.01) 23% in tannin-treated litter compared to the control (2.8 ± 0.1 µmol/g). Conversely, the residual uric acid concentration was 1.6-fold higher (p=0.02) in litter treated with the pine bark tannin than in the control litter. Urea concentrations were unaffected by tannin treatment (p>0.05). Results suggest that pine bark tannin treatment may preserve uric acid and reduce ammonia volatilization in composted litter while aiding Salmonella control.

Abstract Red cabbage (Brassica oleracea L. var. capitata f. rubra DC.) extract has been demonstrated hypolipidemic and antioxidant capacity. Herein, we investigated the effect of red cabbage aqueous extract (RC) or fenofibrate (FF) in oxidative stress induced by Triton WR-1339 in rats. The antioxidant capacity was evaluated through the superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities and, thiobarbituric reactive species (TBARS) and protein carbonyl (PC) levels in erythrocytes, liver, kidneys, cerebral cortex and hippocampus of male rats. The alterations promoted by Triton WR-1339 in enzymatic antioxidant defense in the liver, kidneys and hippocampus were reversed by RC or FF treatments. The TBARS and PC levels increased in the liver, cerebral cortex and hippocampus of hyperlipidemic rats were decreased by the treatments with RC or FF. These findings demonstrated that RC is a potential therapy to treat diseases not only involving dyslipidemic condition but also oxidative stress.

Estudos vêm demonstrando que o exercício de força reduz a pressão arterial para níveis abaixo dos valores de repouso, entretanto este não é um achado universal. O número de repetições do exercício parece influenciar essas respostas. Assim, o objetivo do estudo foi analisar os efeitos do exercício de força realizado com repetições até a falha concêntrica sobre a pressão arterial de 24 horas em mulheres hipertensas. Treze mulheres hipertensas foram submetidas a três sessões experimentais em ordem aleatória: controle (C), exercício de força até a falha concêntrica (FC) e exercício de força com repetições até a redução da cadência (RC). Antes e 24 horas após as sessões as variáveis cardiovasculares - descenso noturno, ascensão matutina e presença ou não de padrão dipper - foram avaliadas por meio de monitorização ambulatorial da pressão arterial. Nos períodos diurno e noturno, não houve diferença significativa entre os três grupos. Entretanto, após FC e C, menos sujeitos apresentaram padrão dipper da pressão arterial (46% e 38%, respectivamente) do que quando comparado aos grupos RC (77%), p=0.047. Como conclusão, o FC atenuou a o padrão dipper da pressão arterial noturna em mulheres hipertensas.

Studies have shown that resistance exercise reduces 24-hour blood pressure to levels below resting values, although this is not a universal finding. The number of repetitions has been shown to influence this response. Thus, the aim of the study was to analyze the effects of resistance exercise performed until failure (UF) on 24-hour blood pressure in hypertensive women. Thirteen hypertensive women underwent three experimental sessions in random order: UF, resistance exercise with repetitions before concentric failure (BF) and control (C). Prior to and up to 24 hours after the sessions, cardiovascular variables, as well as the nocturnal fall in blood pressure, the morning surge, and the presence or absence of a blood pressure dip pattern were established using an ambulatory blood pressure monitor. In both wakefulness and sleep there was no significant difference among the three groups. However, after UF and C fewer patients presented a dip in blood pressure (46% and 38%, respectively) compared BF (77%), p=0.047. In conclusion, the UF attenuated blood pressure dips at night in hypertensive patients.

O objetivo deste trabalho foi determinar as características florais de oito cultivares de maracujazeiro-azedo e identificar seus polinizadores, bem como avaliar a influência da polinização natural na qualidade dos frutos, na região de Tangará da Serra, MT. Utilizou-se o delineamento inteiramente casualizado, com dez repetições e uma flor por parcela para avaliar a morfometria, e com quatro repetições e cinco flores por cultivar para determinar o índice de frutificação. Avaliaram-se os seguintes parâmetros: morfologia e morfometria floral, longevidade floral, frequência de visitantes florais, índice de frutificação natural e qualidade de fruto. A morfologia e a morfometria das flores foram compatíveis com a polinização por abelhas de grande porte; também foram compatíveis com a polinização por abelhas de médio porte nas cultivares IAC-275-Maravilha, IAC-277-Jóia, BRS SC1, BRS RC e BRS GA1. A maior longevidade floral foi observada nas cultivares IAC-277-Jóia, BRS GA1, BRS RC e BRS OV1. A frequência de abelhas como Xylocopa (2,0%) e Bombus (3,9%) foi baixa, e 'BRS GA1' recebeu o maior número de visitas destas abelhas. O índice de frutificação natural foi baixo (36,67%). Os frutos de polinização natural apresentam características físicas compatíveis com as exigidas pelo mercado consumidor.

The objective of this work was to determine the floral traits of eight cultivars of sour passion fruit and identify their pollinators, as well as to evaluate the influence of natural pollination on fruit quality, in the region of Tangará da Serra, MT, Brazil. A completely randomized experimental design was carried out, with ten replicates and one flower per plot to evaluate morphometry, and with four replicates and five flowers per cultivar to determine the fruiting rate. The following parameters were evaluated: flower morphology and morphometry, flower longevity, frequency of floral visitors, natural fruiting rate, and fruit quality. Flower morphology and morphometry were compatible with pollination by large-size bees; they were also compatible with pollination by medium-size bees for the cultivars IAC-275-Maravilha, IAC-277-Jóia, BRS SC1, BRS RC, and BRS GA1. The greatest flower longevity was observed for the IAC-277-Jóia, BRS GA1, BRS RC, and BRS OV1 cultivars. The frequency of bees as Xylocopa (2.0%) and Bombus (3.9%) was low, and 'BRS GA1' received the highest number of these bee visits. Natural fruiting rate was low (36.67%). Naturally pollinated fruit show physical traits compatible with those required by the market standards.

O objetivo do presente trabalho foi estudar o efeito de diferentes técnicas de pré-resfriamento para a conservação de melões Cantaloupe 'Hy Mark'. As formas de pré-resfriamento testadas foram: [1] resfriamento na câmara de armazenamento (RC); [2] pré-resfriamento com ar forçado (RAF) até a temperatura da polpa atingir 8 ºC; [3] pré-resfriamento em água (RA) até 8 ºC; [4] RA até 15 ºC e [5] 24 horas a 20 ºC antes do RC (retardamento do resfriamento - RR). Com o pré-resfriamento em ar forçado até 8 °C e o pré-resfriamento em água até 15 °C, obteve-se maior firmeza e menor escurecimento da polpa, sendo as melhores formas de pré-resfriamento para melões Cantaloupe 'Hy Mark'.

The aim of this work was to study the effect of different techniques of pre-cooling for the conservation of 'Hy Mark' melons. The following pre-cooling treatments were evaluated: [1] cooling the fruits in the storage chamber (RC), [2] pre-cooling with forced-air (FAPC) until the pulp temperature reached 8 °C, [ 3] pre-cooling in water (WPC) to 8 ºC, [4] WPC to 15 °C and [5] 24 hours at 20 °C before the RC (delay of cooling - RR). With pre-cooling in forced air at 8 °C and pre-cooling at 15 °C, high firmness and reduced internal browning were obtained, being the best ways of pre-cooling Cantaloupe 'Hy Mark' melons.